Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| chronic chlamydia pneumoniae infection is associated with a serum lipid profile known to be a risk factor for atherosclerosis. | chlamydia pneumoniae infection has been associated with coronary heart disease. to evaluate the mechanisms of this association, we studied whether chronic c. pneumoniae infection affects serum lipid values similarly to acute infections. triglyceride, total and hdl cholesterol concentrations, and c. pneumoniae antibodies were measured from paired serum samples of 415 finnish males taken 3 years apart. chronic infection, defined as persistent igg and iga antibodies, was found in 20%, and the antib ... | 1997 | 9409275 |
| [chlamydia pneumoniae infection in a family]. | history and symptoms: for 11 weeks a 38-year-old woman had suffered from a respiratory infection with peribronchitis, nocturnal coughing fits and earache. investigations, treatment and course: the chlamydia-cfr titre was raised. subsequent throat swabs of her husband and two daughters grew chlamydia pneumoniae (c.p.), but not in her case; 5 days earlier she had been started on roxithromycin. 3 weeks before the patient fell ill her two daughters had a flu-like illness with cough and subfebrile te ... | 1997 | 9410714 |
| [community-acquired pneumonia: etiological diagnosis]. | microbiological and immunoserological approaches were used in etiological diagnosis of community-acquired pneumonia. it was concluded that streptococcus pneumoniae, staphylococcus aureus, pseudomonas aeruginosa, legionella pneumophila and klebsiella pneumoniae predominated in the etiological structure of present severe community-acquired pneumonia. the most actual causative agents of nonsevere community-acquired pneumonia in persons under 60 were s. pneumoniae, hemophilus influenzae, mycoplasma ... | 1997 | 9412402 |
| does chlamydia pneumoniae cause coronary atherosclerosis and should we all take macrolides? | 1997 | 9413231 | |
| murine models of chlamydia pneumoniae infection and atherosclerosis. | chlamydia pneumoniae have been demonstrated in atherosclerotic lesions but not in normal arteries. an animal model of both c. pneumoniae and atherosclerosis is needed to investigate the role of the organism in atherosclerosis. apolipoprotein (apo) e-deficient transgenic mice, which spontaneously develop atherosclerosis, and c57bl/6j mice, which only develop atherosclerosis on an atherogenic diet, were evaluated. following single and multiple intranasal inoculations of apoe-deficient transgenic m ... | 1997 | 9086145 |
| possible nosocomial transmission of psittacosis. | to investigate a cluster of seven pneumonia cases among persons exposed to a pet-shop worker hospitalized with psittacosis. | 1997 | 9090543 |
| [community acquired pneumonia. reliability of the criteria for deciding ambulatory treatment]. | to determine whether criteria for not admitting community-acquired pneumonia (cap) patients diagnosed in the emergency room are appropriate, and to characterize the symptoms, etiology and course of cap. this one-year prospective, protocol study of immunocompetent cap patients diagnosed in the emergency room of our hospital enrolled patients not considered to require hospital admission according to the recommendations of the spanish society of respiratory disease (separ). medical histories, chest ... | 1997 | 9091117 |
| infection of acanthamoeba castellanii by chlamydia pneumoniae. | chlamydia pneumoniae is an intracellular respiratory pathogen, which, similar to legionella, might have developed mechanisms to escape the intracellular bactericidal activity of both human host cells and amoeba. we therefore investigated the intracellular growth and survival of c. pneumoniae in acanthamoeba castellanii by using cell culture, immunofluorescence microscopy, and electron microscopy. a castellanii was incubated with purified elementary bodies of c. pneumoniae tw 183 at a concentrati ... | 1997 | 9097437 |
| chlamydia pneumoniae as a new source of infectious outbreaks in nursing homes. | to determine the extent and severity of illness and mode of transmission of chlamydia pneumoniae infection in 3 nursing home outbreaks. | 1997 | 9103345 |
| phylogenetic analysis of the genus chlamydia based on 16s rrna gene sequences. | the phylogenetic relationships among chlamydia spp. were investigated by comparing 16s rrna gene sequences. in this analysis we used 14 strains of chlamydia psittaci, including seven feline isolates, two avian isolates, two human isolates, one bovine isolates, one ovine isolate, and one koala isolate; and nine strains of chlamydia trachomatis, including six human isolates, two swine isolates, and one mouse isolate. a phylogenetic analysis of the 16s rrna gene sequences of these organisms and sev ... | 1997 | 9103632 |
| the ribosomal intergenic spacer and domain i of the 23s rrna gene are phylogenetic markers for chlamydia spp. | current methods used to classify chlamydia strains, including biological, morphological, and dna hybridization techniques and major outer membrane protein (omp1) gene analysis, can be imprecise or difficult to perform. to facilitate classification, 2.8-kb partial ribosomal dna (rdna) segments from a chlamydia trachomatis strain and a chlamydia psittaci strain were amplified by pcr and sequenced. subsequently, a 1,320-bp region in this segment, including both the 16s/23s intergenic spacer (232 +/ ... | 1997 | 9103637 |
| characterization of chlamydia pneumoniae antigens using human t cell clones. | chlamydia pneumoniae infection is followed by the development of antigen-specific cell-mediated immunity (cmi), which is detectable as a positive lymphocyte proliferation (lp) response to c. pneumoniae elementary body (eb) antigen, but the proteins inducing the t cell activation are not known. in the present work the authors used human t lymphocyte clones (tlc) raised against c. pneumoniae eb antigen to characterize c. pneumoniae proteins as t cell-stimulating antigens. a total of 55% of the tlc ... | 1997 | 9105425 |
| relevance of nucleic acid amplification techniques for diagnosis of respiratory tract infections in the clinical laboratory. | clinical laboratories are increasingly receiving requests to perform nucleic acid amplification tests for the detection of a wide variety of infectious agents. in this paper, the efficiency of nucleic acid amplification techniques for the diagnosis of respiratory tract infections is reviewed. in general, these techniques should be applied only for the detection of microorganisms for which available diagnostic techniques are markedly insensitive or nonexistent or when turnaround times for existin ... | 1997 | 9105753 |
| history of macrolide use in pediatrics. | erythromycin, the prototypical macrolide, has been widely used since the 1950s in the management of pediatric infections. erythromycin is the drug of choice for infants and children with legionnaire's disease, pertussis, diphtheria, lower respiratory tract infections caused by mycoplasma pneumoniae, chlamydia pneumoniae and chlamydia trachomatis and enteritis caused by campylobacter jejuni. it is also indicated for treatment of syphilis; for streptococcal, staphylococcal and pneumococcal infecti ... | 1997 | 9109154 |
| causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. | streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis are the most frequently isolated pathogens in patients with acute otitis media (aom). other potential causative pathogens include streptococcus pyogenes in older children and chlamydia pneumoniae in younger children. the recent emergence of penicillin-resistant s. pneumoniae and the increasing frequency of beta-lactamase-producing strains of m. catarrhalis and h. influenzae are creating concerns regarding the use of amoxi ... | 1997 | 9109158 |
| future indications for macrolides. | the antimicrobial spectrum of azithromycin and clarithromycin suggests a number of further uses for these newer macrolides. favorable clinical and bacteriologic responses have been reported with both antibiotics in children with community-acquired pneumonia. response rates were high for overall patient populations and for subgroups with infection caused by mycoplasma pneumoniae and chlamydia pneumoniae. treatment with azithromycin or clarithromycin has resulted in a reduction in mycobacteremia a ... | 1997 | 9109159 |
| [macrolides: indications in 1997]. | a growing class of antibiotics: since the discovery of erythromycin, teh prototype macrolide, this class of antibiotics has grown considerably. roxithromycin, a semi-synthetic erythromycin derivative, has an improved absorbability, tolerability and stability profile. wide indications: current indications for these new compounds for respiratory tract infections are presented and discussed in terms of the most recent consensus conferences. new trends: all current indications (expecting the respira ... | 1997 | 9113049 |
| [asthma and chlamydia pneumoniae. a future prospect for macrolides in general and roxithromycin in particular?]. | a logical hypothesis: recent publications raise the question of an association between chlamydia pneumoniae and asthma. there has been no formal proof justifying routine search for c.pneumoniae in patients with uncontrolled asthma nor for systematic treatment with an antibiotic. open questions: can chlamydia pneumoniae infection initiate or aggravate asthma? are acute manifestations of asthma associated with an overly high frequency of recent c.pneumoniae infection? is a past history of c.pneumo ... | 1997 | 9113050 |
| species identification of chlamydia isolates by analyzing restriction fragment length polymorphism of the 16s-23s rrna spacer region. | the genetic diversity of the 16s-23s rrna spacer region of 12 chlamydia pneumoniae isolates, 7 chlamydia trachomatis isolates (human biovars: the trachoma serovars b and c, the urogenital serovars d, e, and f, and the lymphogranuloma venereum serovar l2; and a mouse biovar), 6 chlamydia psittaci isolates (5 avian isolates and 1 feline isolate), and one chlamydia pecorum isolate was studied. the 16s-23s rrna spacer region was amplified by pcr and digested with the restriction enzymes msei, psti, ... | 1997 | 9114403 |
| detection of chlamydia pneumoniae in human nonrheumatic stenotic aortic valves. | we sought to study the possible presence of chlamydia pneumoniae in aortic valve stenosis (avs). | 1997 | 9120159 |
| the epidemiology of community-acquired pneumonia among hospitalized adults. | to identify and characterize the aetiological agents of community-acquired pneumonia (cap) among hospitalized patients, as an aid in therapeutic decision-making. | 1997 | 9120323 |
| new directions in diagnostics. | infectious diseases are still a significant clinical problem in children, and accurate identification of the causal pathogen plays an important role in clinical management. the availability of an etiologic diagnosis enables the clinician to make appropriate therapeutic decisions and to avoid the indiscriminate use of antibiotics. the availability of a microbiologic diagnosis and the susceptibility profile of the pathogen allows the prompt initiation of suitable antibiotic treatment. however, the ... | 1997 | 9076835 |
| demonstration of chlamydia pneumoniae in the walls of abdominal aortic aneurysms. | seroepidemiologic studies have indicated an association between chronic chlamydia pneumoniae infection and coronary heart disease. the organism, which is a common respiratory pathogen, has been demonstrated in atherosclerotic lesions of the aorta and coronary arteries. abdominal aortic aneurysms are frequently associated with atherosclerosis, and inflammation may actually be an important factor in aneurysmal dilatation. hence it could be assumed that c. pneumoniae may play a role in maintaining ... | 1997 | 9081131 |
| in vitro infection of smooth muscle cells by chlamydia pneumoniae. | recent observations have shown that both chlamydia pneumoniae antigens and dna may be found within atherosclerotic lesions. in this study, we evaluated the ability of c. pneumoniae to infect cells that make up atherosclerotic lesions, including endothelial cells, smooth muscle cells, and cholesterol-loaded smooth muscle cells. the organism readily infected rabbit, bovine, and human aortic smooth muscle cells. cholesterol-loaded smooth muscle cells were even more susceptible to c. pneumoniae infe ... | 1997 | 9009304 |
| prevalence of positive serology for acute chlamydia pneumoniae infection in emergency department patients with persistent cough. | to determine the prevalence of acute chlamydia pneumoniae infection in ed patients presenting with a persistent cough. | 1997 | 9063543 |
| evaluation of chlamydia immunoglobulin m (igm), igg, and iga relisas medac for diagnosis of chlamydia pneumoniae infection. | chlamydia pneumoniae is an important pathogen responsible for a variety of respiratory diseases in humans. cell culture remains the most specific method for c. pneumoniae diagnosis, but it is labor-intensive and time-consuming. thus, serology, particularly microimmunofluorescence (mif) testing, is frequently utilized. however, the mif test has a significant subjective component. we evaluated a new serological test: chlamydia immunoglobulin m (igg, iga, and igm relisas medac, based on a recombina ... | 1997 | 9067658 |
| antibiotics: neither cost effective nor 'cough' effective. | clinicians often prescribe antibiotics to treat acute bronchitis despite scant evidence that this approach is effective at speeding symptom resolution. because patients infected with bacteria but not treated with antibiotics may need to return in the future for therapy, however, this approach may be cost effective. | 1997 | 9071245 |
| elispot assay for chlamydia-specific, antibody-producing cells correlated with conventional complement fixation and microimmunofluorescence. | chlamydia antigens cross-reactive with pneumoniae (twar), psittaci, and trachomatis strains were used to evaluate the elispot assay for detecting antigen-specific, antibody-secreting cells (asc). human blood specimens from healthy and hospitalized persons were randomly collected and tested by coating the nitrocellulose membrane at the base of microtiter wells. ficoll-separated mononuclear cells from blood specimens collected in edta were incubated in the wells with iscove's growth medium in co2 ... | 1997 | 9021524 |
| serological evidence of an association between chlamydia pneumoniae infection and lung cancer. | epidemiological evidence suggests that airway obstruction is an independent risk factor for lung cancer and that this cannot be explained by active or passive smoking alone. chlamydia pneumoniae infection has been associated with chronic bronchitis and its exacerbates. our aim was to evaluate the association between chronic c. pneumoniae infection and risk of lung cancer among male smokers. smoking males with lung cancer (n = 230) and their age- and locality-matched controls were selected among ... | 1997 | 9036866 |
| the relation between chlamydia pneumoniae and atherosclerosis. | 1997 | 9038684 | |
| antigenic and molecular analyses of different chlamydia pneumoniae strains. | chlamydia pneumoniae is an important human respiratory pathogen. classification of c. pneumoniae isolates into distinguishable serovars or genotypes has not yet been reported. to determine whether antigenic or molecular variants among c. pneumoniae isolates exist, six strains were studied via immunoblot analysis and dna sequence determination of the entire major outer membrane protein (momp) gene omp1. the strains included four prototype strains and two clinical isolates from our laboratory. imm ... | 1997 | 9041400 |
| in vitro activity of bay 12-8039, a new fluoroquinolone. | the in vitro activity of bay 12-8039, a new fluoroquinolone, was studied in comparison with those of ciprofloxacin, trovafloxacin (cp 99,219), cefpodoxime, and amoxicillin-clavulanate against gram-negative, gram-positive, and anaerobic bacteria. its activity against mycobacteria and chlamydia was also investigated. bay 12-8039 was active against members of the family enterobacteriaceae (mic at which 90% of strains tested were inhibited [mic90s] < or = 1 microgram/ml, except for serratia spp. mic ... | 1997 | 8980763 |
| widely used, commercially available chlamydia pneumoniae antigen contaminated with mycoplasma. | mycoplasma contamination was detected in a widely used commercially available chlamydia pneumoniae antigen preparation. contamination was studied with a mycoplasma group-specific 16s rrna polymerase chain reaction (pcr) and sequence analysis. several lots of the purified c. pneumoniae antigen from the washington research foundation appeared to be contaminated with the same mycoplasma species, which appeared to be closely related to m. arginini. antigen slides prepared for the detection of chlamy ... | 1997 | 9152039 |
| chlamydia species infect human vascular endothelial cells and induce procoagulant activity. | chlamydia pneumoniae infections have been linked with myocardial infarction, stroke, and the development of atherosclerosis by epidemiologic studies, immunohistochemical studies, and electron microscopic studies. the mechanisms underlying this association are unknown. | 1997 | 9154297 |
| [chlamydia and respiratory pathology]. | 1997 | 9453820 | |
| the in-vitro activity of grepafloxacin against chlamydia spp., mycoplasma spp., ureaplasma urealyticum and legionella spp. | the activity of grepafloxacin, a new orally active fluoroquinolone, was compared with the activities of ofloxacin, clarithromycin and doxycycline against chlamydia pneumoniae, chlamydia trachomatis, mycoplasma pneumoniae, mycoplasma hominis and ureaplasma urealyticum, and with the activities of ofloxacin, clarithromycin and rifampicin against legionella spp. grepafloxacin (mic range 0.06-0.12 mg/l) was some 8-16 times more active than ofloxacin against the chlamydiae, showing activity similar to ... | 1997 | 9484871 |
| [severe pneumonia caused by chlamydia pneumoniae in a patient treated with steroids for bronchial asthma]. | a case of bilateral severe pneumonia caused by chlamydia pneumoniae has been described in a female patient with bronchial asthma. both the clinical course and massive radiological changes, as-well as the fact that pneumonia occurred during the patients hospitalization and the treatment with, among other drugs, prednisone lead to the presumptive diagnosis of hospital acquired pneumonia or tuberculosis. the instituted therapy turned out ineffective. only when chlamydia pneumoniae was found in the ... | 1997 | 9461730 |
| [bronchitis and alveolitis in the course of chlamydia pneumoniae infection]. | a case of a 38-year old male with respiratory failure in the course of infection by chlamydia pneumoniae has been described. inflammation of bronchioles and alveoli was diagnosed on the basis of clinical examination and analysis of cellular components of bronchoalveolar lavage fluid (balf). the diagnosis was confirmed by bacteriological examination of the culture infected by the material collected from the patient. therapy with doxycycline was instituted which resulted in remission of symptoms. ... | 1997 | 9461732 |
| [chlamydia pneumoniae as an etiologic factor in disease of the respiratory tract]. | the described recently species of chlamydia pneumoniae is the subject of a large number of scientific reports. the majority of infections caused by this microorganism are asymptomatic. however, a lot of cases of symptomatic infections have been described with both mild and severe clinical course. symptoms related to infection may affect both upper and lower parts of the respiratory tract and may be accompanied by disorders in other systems and organs. reports on the influence of chronic inflamma ... | 1997 | 9461735 |
| chlamydia pneumoniae: can it cause atherosclerosis? | 1997 | 9529847 | |
| lp(a) lipoprotein is a major risk factor for cardiovascular disease: pathogenic mechanisms and clinical significance. | the results of two previous and two recent studies of middle-aged males and females are presented to exemplify the clinical importance of lipoprotein(a) (lp(a)) as a risk factor for atherosclerosis and coronary heart disease. in these studies various conventional and recently suggested risk factors were included and different methods for lp(a) quantification were used. lp(a) was a significant risk factor in all four studies. in the recent prospective case-control study, lp(a) and cholesterol wer ... | 1997 | 9520117 |
| serological survey of chlamydial antibody in post-natal sera. | questionnaires (3426; 72.8%) and blood samples (3890; 82.6%) were analysed from 4704 women post-natally. the answers to the questionnaire confirmed that those patients living in areas with the highest percentage employed in agriculture were most likely to be in direct or indirect contact with sheep or sheep products. when the 788 (20.3%) of the sera with group specific antibody were examined for type-specific antibody, 291 (7.5%) reacted with chlamydia trachomatis, 153 (3.9%) with chlamydia pneu ... | 1997 | 9459402 |
| pneumococcal community-acquired pneumonia in 148 hospitalized adult patients. | in a previous prospective study, streptococcus pneumoniae was identified as the causative agent in 148 (42.8%) of 346 adult patients hospitalized over the course of one year with community-acquired pneumonia (cap) in the soroka medical center, beer-sheva, israel. the present study characterizes those cases in which streptococcus pneumoniae was the only pathogen and those in which additional etiological agents were identified. pneumococcal cap was diagnosed by standard blood cultures or positive ... | 1997 | 9495665 |
| chlamydia pneumoniae and cardiovascular disease. | 1997 | 9534306 | |
| [tricuspid endocarditis caused by chlamydia pneumoniae. apropos of a case]. | the authors report a case of tricuspid blood culture-negative endocarditis where serologic investigations showed high titers of antibodies against. chlamydia pneumoniae, thus suggesting its possible role as the causal agent. the treatment consisted of polymicrobial therapy using ciprofloxacine and doxycycline with favorable response thus avoiding surgical intervention. in all cases of culture-negative endocarditis not responding to classic empiric antibiotics, chlamydia infection should be suspe ... | 1997 | 9539844 |
| calculus and coronary artery disease. | 1997 | 9560719 | |
| demonstration of chlamydia pneumoniae in patients with chronic pharyngitis. | 12 patients with longstanding throat symptoms, who were also positive by pcr (polymerase chain reaction) for chlamydia pneumoniae were selected for a longitudinal study to determine whether c. pneumoniae is an aetiological agent for chronic pharyngitis. specimens for culture and pcr detection of c. pneumoniae were taken from the retropharyngeal wall and blood specimens were taken for serology. biopsies were taken from the mucosal membrane of the retropharyngeal wall for histological and immunohi ... | 1997 | 9571739 |
| absence of porphyromonas asaccharolytica, bacteroides fragilis and chlamydia pneumoniae in human subgingival plaque. | little is known about the presence of common medical pathogens in the human oral cavity. using a 16s rrna-based pcr identification method, this study determined the occurrence of porphyromonas asaccharolytica, bacteroides fragilis and chlamydia pneumoniae in subgingival plaque from 50 adults with advanced periodontitis. each patient contributed samples from 3 deep periodontal pockets collected by paper points. the pcr primers were for p. asaccharolytica 5'-ctc tag cta gag tgt act gg-3' and 5'-at ... | 1997 | 9573814 |
| [means of diagnosis of chlamydia pneumoniae infection]. | 1997 | 9616810 | |
| [chlamydia pneumoniae and respiratory pathology. epidemiological data]. | 1997 | 9616811 | |
| [chlamydia pneumoniae and asthmatic disease in adults: relations to be clarified]. | 1997 | 9616812 | |
| [role of chlamydia pneumoniae in asthmatic disease in children]. | 1997 | 9616813 | |
| [does infectious asthma exist?]. | 1997 | 9616814 | |
| previous cytomegalovirus or chlamydia pneumoniae infection and risk of restenosis after percutaneous transluminal coronary angioplasty. | 1997 | 9652570 | |
| [theoretical basis for the antibiotic therapy of the upper part of the respiratory system]. | the paper presents the views on the etiology of infections in the respiratory system. beside the so called "old pathogens" such as streptococcus pneumoniae, haenophilus influenzae, moraxella catarrhalis, "atypic" microorganisms are becoming more and more important, i.e. mycoplasma pneumoniae, legionella pneumophila, chlamydia pneumoniae. mixed flora with aerobic and anaerobic bacteria is observed in chronic infections. viral infections facilitate bacterial infections. antibiotic used first shoul ... | 1997 | 9757681 |
| igg antibodies to chlamydial and mycoplasma infection plus c-reactive protein related to poor outcome in unstable angina. | evidence exists showing an association between chlamydial infection and infarction. our purpose was to identify an interactive relationship between chlamydia pneumoniae and unstable angina. | 1997 | 9585827 |
| [assessment of sputum culture and serology for detection of chlamydia pneumoniae in patients with symptomatic acute respiratory tract infection]. | to evaluate sputum culture and serology for detection of chlamydia pneumoniae (c. pneumoniae) in adult patients with acute respiratory tract infection and normal subjects. | 1997 | 10072833 |
| acute bronchitis in adults: commonly diagnosed but poorly defined. | this article reviews the existing literature about acute bronchitis, a condition commonly diagnosed but poorly defined. the little epidemiologic research that has been done has failed to identify a microbiologic etiology approximately 60% to 85% of the time. the majority of cases appear to be caused by viruses, but 25% of adults with nonspecific lower respiratory symptoms may actually have pertussis. mycoplasma pneumoniae and chlamydia pneumoniae probably play minor roles. although clinicians fr ... | 1997 | 9004313 |
| rabbit model for chlamydia pneumoniae infection. | a rabbit model was established for chlamydia pneumoniae infection that may be helpful to understand the pathogenesis of disease in humans. twelve, pathogen-free, 1-month-old new zealand white rabbits were inoculated with 1.0 x 10(7) to 5.0 x 10(7) cfu of purified c. pneumoniae (atcc strain vr 1310) via the nasopharynx (1 rabbit died immediately postinoculation, and 11 were available for study). five controls were inoculated with the carrier buffer. ten of the 11 study rabbits demonstrated serolo ... | 1997 | 8968879 |
| a novel method for isolation of chlamydia pneumoniae by treatment with trypsin or edta. | to establish a novel method for the efficient isolation of chlamydia pneumoniae, experiments were performed to determine the effects of edta or trypsin treatment of c. pneumoniae on its adsorption and inclusion body formation. treatment of c. pneumoniae with 0.1% trypsin or 1 mm edta significantly increased inclusion body-forming activity from 8,000- to 10,000-fold higher than that of the control. c. pneumoniae was successfully isolated in cultured cells which were inoculated with clinical speci ... | 1997 | 9163501 |
| chlamydia pneumoniae antibodies and serum lipids in finnish men: cross sectional study. | 1997 | 9167563 | |
| in vitro and in vivo activities of am-1155, a new fluoroquinolone, against chlamydia spp. | the in vitro and in vivo activities of am-1155, a new quinolone, against chlamydia spp. were investigated. the mic of am-1155 for 10 standard strains of different chlamydia spp. and 25 wild-type strains of chlamydia pneumoniae isolated in japan, which were morphologically different from clinical isolates from the united states, ranged from 0.063 to 0.125 microg/ml. its activity was almost the same as those of sparfloxacin and tosufloxacin and was 4 and 16 times superior to those of levofloxacin ... | 1997 | 9174194 |
| chlamydia pneumoniae pneumonia with acute hemorrhagic pericarditis in patient with acute leukemia. | 1997 | 9175336 | |
| community-acquired pneumonia in old age: a prospective study of 91 patients admitted from home. | to characterize the background, aetiology, clinical course and outcome of community-acquired pneumonia (cap) in elderly compared with younger patients. | 1997 | 9177661 |
| antibodies against chlamydia pneumoniae, cytomegalovirus, enteroviruses and respiratory syncytial virus in patients with polymyalgia rheumatica. | to investigate the association between the onset of polymyalgia rheumatica (pmr) and prior or persistent infection with chlamydia pneumoniae or cytomegalovirus (cmv) (both known to infect the vessel wall) enteroviruses (ev) or respiratory syncytial virus (rsv). | 1997 | 9177926 |
| clarithromycin. a review of its efficacy in the treatment of respiratory tract infections in immunocompetent patients. | clarithromycin is a broad spectrum macrolide antibacterial agent active in vitro and effective in vivo against the major pathogens responsible for respiratory tract infections in immunocompetent patients. it is highly active in vitro against pathogens causing atypical pneumonia (chlamydia pneumoniae, mycoplasma pneumoniae and legionella spp.) and has similar activity to other macrolides against staphylococcus aureus. streptococcus pyogenes, moraxella catarrhalis and streptococcus pneumoniae. hae ... | 1997 | 9179528 |
| rapid diagnosis of respiratory chlamydia pneumoniae infection by nested touchdown polymerase chain reaction compared with culture and antigen detection by eia. | chlamydia pneumoniae is a common cause of respiratory tract infection and community-acquired pneumonia. during an extensive outbreak of c. pneumoniae in northern sweden, 319 respiratory samples from 129 persons were collected. sputum, throat, and nasopharyngeal samples were obtained and analyzed by nested touchdown polymerase chain reaction (pcr), eia, and culture in hep-2 and mccoy cells. serology was performed by complement fixation and microimmunofluorescence tests. by pcr, 30 patients were d ... | 1997 | 9180199 |
| severe community-acquired pneumonia, shock and multiorgan dysfunction syndrome caused by chlamydia pneumoniae. | chlamydia pneumoniae has been increasingly recognized as an important aetiological agent in community-acquired pneumonia. a case of severe community-acquired pneumonia and multifunction dysfunction syndrome resulting from chlamydia pneunoniae infection in a previously healthy adult is presented. | 1997 | 9183314 |
| in-vitro activity of dirithromycin against chlamydia pneumoniae. | the in-vitro susceptibilities of 12 strains of chlamydia pneumoniae were determined for dirithromycin, a new macrolide antibiotic, erythromycyclamine, its active metabolite, and erythromycin. both dirithromycin and erythromycyclamine had an mic90 of 2 mg/l, as compared with 0.062 mg/l for erythromycin. the combination of dirithromycin and erythromycyclamine appeared to be additive. determination of the role of dirithromycin for the treatment of c. pneumoniae infection will depend on the results ... | 1997 | 9184366 |
| incidence, etiologic pathogens, and diagnostic testing of community-acquired pneumonia. | determination of the etiologic pathogens of community-acquired pneumonia has been problematic because of the lack of reliable rapid laboratory diagnostic tools as well as the controversy concerning diagnostic criteria. in the studies reviewed here, a specific pathogen was identified in 39% to 88% of patients. streptococcus pneumoniae remains the most common cause of community-acquired pneumonia. depending on the demographics of the study, between 2% to 43% of cases have been attributed to legion ... | 1997 | 9193852 |
| atypical pathogen pneumonia. | the term atypical pathogens has been applied in recent years to chlamydia pneumoniae, mycoplasma pneumoniae, and the various species of legionella. the incidence of pneumonia caused by these pathogens has increased with the development of specific diagnostic techniques. atypical pathogen community-acquired pneumonia demonstrates a broad spectrum of severity from a mild disease not requiring hospitalization to adult respiratory distress syndrome necessitating mechanical ventilation. the clinical, ... | 1997 | 9193855 |
| prevalence of chlamydia pneumoniae in healthy children and in children with respiratory tract infections. | chlamydia pneumoniae causes respiratory tract infections in adults, but little is known about its significance for acute or persistent respiratory tract infections in children. | 1997 | 9194103 |
| improvement of growth of chlamydia pneumoniae on hep-2 cells by pretreatment with polyethylene glycol in combination with additional centrifugation and extension of culture time. | the following adaptations led to improved growth of chlamydia pneumoniae on hep-2 cells compared to that by the standard method: monolayer preincubation with 7% polyethylene glycol (peg), extension of incubation time to 7 days, and extension of incubation to 7 days in combination with centrifugation on days 3, 4, and 5. these adaptations resulted in approximate increases in numbers of inclusion-forming units (ifu) of 2-, 5-, and 69-fold, respectively. a combination of preincubation with peg, pro ... | 1997 | 9196215 |
| bacteriosclerosis. | 1997 | 9199827 | |
| plasmid diversity in chlamydia. | chlamydiae exhibit low interspecies dna homology and plasmids from different chlamydial species can be readily distinguished by southern blot analysis and restriction enzyme profiling. in contrast, available plasmid sequence data from within the species chlamydia trachomatis indicate that plasmids from human isolates are highly conserved. to evaluate the nature and extent of plasmid variation, the complete nucleotide sequences were determined for novel plasmids from three diverse non-human chlam ... | 1997 | 9202459 |
| isolation of chlamydia pneumoniae from a carotid endarterectomy specimen. | chlamydia pneumoniae has been associated with atherosclerotic cardiovascular disease by both seroepidemiologic studies and direct detection of the organism in atherosclerotic plaque by electron microscopy (em), immunocytochemistry (icc), and polymerase chain reaction (pcr). despite the frequent detection of the organism in atheromatous cardiovascular specimens by these methods, only 1 cardiovascular isolate of c. pneumoniae, obtained from a coronary artery, has been previously reported. this stu ... | 1997 | 9207386 |
| evolutionary relationships among members of the genus chlamydia based on 16s ribosomal dna analysis. | nucleotide sequences from strains of the four species currently in the genus chlamydia, c. pecorum, c. pneumoniae, c. psittaci, and c. trachomatis were investigated. in vitro-amplified rna genes of the ribosomal small subunit from 30 strains of c. pneumoniae and c. pecorum were subjected to solid-phase dna sequencing of both strands. the human isolates of c. pneumoniae differed in only one position in the 16s rrna gene, indicating genetic homogeneity among these strains. interestingly, horse iso ... | 1997 | 9209033 |
| [the causative agents of chlamydiosis in agricultural animals and their pathogenicity for man]. | 1997 | 9221670 | |
| [the relationship between chlamydia pneumoniae and atherosclerotic lesions of the aorta]. | although atherogenic main factors have been extensively studied, there are others whose real importance has not been well defined. there are some pathologic and immunologic evidences relating several infectious agents with the genesis or development of coronary atherosclerosis. recently, a link has been established between chlamydia pneumoniae and atherogenesis, due to immunological evidence of infection in human atherosclerotic lesions. we studied 16 aortic specimens obtained from necropsies pe ... | 1997 | 9221706 |
| chlamydia pneumoniae and coronary heart disease. | 1997 | 9224071 | |
| [synchronous variations in the incidence of temporal arteritis and polymyalgia rheumatica in danish counties. association with epidemics of mycoplasma pneumonia infection]. | the incidences of temporal arteritis and polymyalgia rheumatica during a twelve year period were studied in different regions of denmark. data concerning the incidences of these diagnoses were obtained from two general hospitals from 1982 to 1994 and from the national patient register of all diagnoses from all hospitals in 13 of 16 danish counties from 1982 til 1993. data from all temporal artery biopsies in two counties were also obtained. serological epidemiological surveillance data concernin ... | 1997 | 9229871 |
| application of a nested, multiplex pcr to psittacosis outbreaks. | we developed a nested, multiplex pcr for simultaneous detection of three species of chlamydiae in human and avian specimens. the pcr was designed to increase sensitivity and to circumvent inhibitors of pcr present in clinical specimens. the target sequence was the 16s rrna gene. the first-step pcr was genus specific, and the second-step pcr was multiplexed (i.e., had multiple primer sets in the same tube) and could discriminate among chlamydia pneumoniae, chlamydia psittaci, and chlamydia tracho ... | 1997 | 9230378 |
| chlamydial disease--more than just abortion. | 1997 | 9232115 | |
| [chlamydia psittaci and chlamydia pneumoniae infection in caceres]. | the study of the clinical and epidemiological characteristics of infectious process caused by chlamydia pneumoniae and chlamydia psittaci in our medium, cáceres. | 1997 | 9235099 |
| infection and coronary heart disease. | a large body of evidence exists that implicates a number of microbial agents in the pathogenesis of coronary heart disease (chd). this, if proven, may have far-reaching implications for the prevention and treatment of chd and other atherosclerotic disease. the histopathology of atherosclerosis and its natural history suggest infectious causation at many points along the progression of disease, particularly with regard to chd, and a number of pathogens have been the focus of study. viral agents i ... | 1997 | 9236736 |
| detection of chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction. | to study surgically excised vascular tissue from lower extremities for the presence of chlamydia pneumoniae, to extend the previously described association of the organism with atherosclerosis. | 1997 | 9240318 |
| lymphocyte responses to chlamydia antigens in patients with coronary heart disease. | to clarify the relationship of chlamydia pneumoniae infection and coronary atherosclerosis we studied cell-mediated and humoral immune responses to chlamydia in 93 patients with angiographically confirmed coronary heart disease and in 115 controls without angiographically demonstrable lesions. | 1997 | 9243142 |
| epidemiology of encephalitis in children. a prospective multicentre study. | we found 175 cases with acute encephalitis in a population of 791,712 children aged 1 month-15 years during a 2-year surveillance period in 1993-1994. the overall incidence was 10.5/100,000 child-years with the highest figure in children < 1 year of age, 18.4/100,000 child-years. the microbial diagnosis was considered proven or suggested in 110 cases (63%); varicella zoster, respiratory and enteroviruses comprised 61% of these, and adeno, epstein barr-, herpes simplex and rota viruses comprised ... | 1997 | 9243237 |
| elevated chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. | the clinical significance of the association between elevated anti-chlamydia pneumoniae (cp) antibody titres and coronary heart disease (chd) is unclear. we explored the relationship between antibodies against cp and future cardiovascular events in male survivors of myocardial infarction (mi). the effect of azithromycin antibiotic therapy was assessed in a subgroup of post-mi patients. | 1997 | 9244203 |
| [anti-chlamydia pneumoniae antibodies and production of interleukin 6 in acute myocardial infarct]. | chlamydia pneumoniae (c.p.) has been correlated with acute myocardial infarction (ami). high levels of anti-c.p. antibodies and circulating immune complexes containing c.p. lypopolyaaccharide (lps) antigens have been demonstrated in ami. lps antigen and especially chlamydial lps is one of the best antigen and it is also a very good interleukin inductor. moreover, interleukin 6 (il-6) has been observed in ami patients. the aim of our study was to assess the possible relationships between anti-c.p ... | 1997 | 9244752 |
| incidence of community-acquired pneumonia requiring hospitalization. results of a population-based active surveillance study in ohio. the community-based pneumonia incidence study group. | pneumonia is the leading cause of death due to infectious diseases in the united states; however, the incidence of most infections causing community-acquired pneumonia in adults is not well defined. | 1997 | 9250232 |
| molecular biology of the chlamydia pneumoniae surface. | chlamydia pneumoniaeis a fastidious microorganism with a characteristic biphasic lifecycle causing a variety of human respiratory tract infections. there is limited knowledge about the molecular biology of c. pneumoniae, and only a few genes have been sequenced. the structure of the chlamydial surface differs from that of chlamydia trachomatis. in order to study the surface of c. pneumoniae we generated monoclonal antibodies (mabs) against c. pneumoniae strain vr-1310 and selected 14 mabs that r ... | 1997 | 9259071 |
| comparison of nasopharyngeal and throat swabs for the detection of chlamydia pneumoniae and mycoplasma pneumoniae by polymerase chain reaction. | nasopharyngeal and throat swabs taken from 66 patients presenting at the department of infectious disease with symptoms of upper and lower respiratory tract infection were analysed by use of the polymerase chain reaction (pcr) for chlamydia pneumoniae and mycoplasma pneumoniae. a total of 18 patients (27%) were positive by pcr for c. pneumoniae. all 18 patients were positive from throat swabs, and three were also positive from nasopharyngeal specimens. the difference between the outcome of pcr u ... | 1997 | 9259072 |
| assay of antibiotic susceptibility of chlamydia pneumoniae. | it is well known that treatment of chlamydia pneumoniae infections is difficult. high doses and prolonged treatment is often needed to achieve clinical cure despite good in vitro effect of the drugs used. we here discuss different methodological problems in the determination of mic and mbc values of c. pneumoniae. the length of the preincubation time and the lack of fluctuation of the antibiotic concentrations may affect the outcome of the currently used assay. | 1997 | 9259073 |
| animal models for chlamydia pneumoniae infection. | there is accumulating evidence that persistent chlamydia pneumoniae infections occur in vivo. animal studies are necessary in order to evaluate the effects of different treatment regimens for eradication of such infections. a mouse model was found to be efficacious for the study of the effects of cortisone and antimicrobial agents on c. pneumoniae infection. | 1997 | 9259074 |
| cell mediated immunity to chlamydia pneumoniae. | the association of chlamydia pneumoniae to several chronic diseases such as atherosclerosis has been suggested serologically and by direct demonstration of organisms in disease lesions. cell mediated immunity is crucial in host defense against intracellular pathogens such as c. pneumoniae. c. pneumoniae is a relatively recently recognized pathogen and the cellular mechanisms in c. pneumoniae immunity have so far remained unstudied. the present review includes the data available on c. pneumoniae ... | 1997 | 9259075 |
| epidemic patterns and carriage of chlamydia pneumoniae in norway. | chlamydia pneumoniae infection, in earlier days misdiagnosed as ornithosis, is very common in norway. the disease develops slowly, a feature that may account for the very large number of subclinical cases, which may be seven fold more common than clinical cases. subclinical cases produce an antibody response similar to that seen in overt clinical disease. silent carriage of c. pneumoniae in healthy individuals may be frequent. therapy based on positive cell culture or polymerase chain reaction ( ... | 1997 | 9259076 |
| respiratory tract infection due to chlamydia pneumoniae in military personnel. | the objective of this investigation was to determine whether chlamydia pneumoniae was involved in an outbreak of respiratory disease among military recruits, 92 patients (average age 20.1 years) were included in the study if they had a sore throat or cough for more than 1 week. in addition to sore throat and cough, fatigue, headache, dyspnoea and vertigo were the most frequent symptoms. the patients received standard treatment with 100 mg of doxycycline b.i.d. for 14 days. in 38.8% of cases symp ... | 1997 | 9259077 |
| respiratory chlamydial infections in a hong kong teaching hospital and association with coronary heart disease. | the microimmunofluorescence antibody technique was used to determine the seroprevalence of antibodies to chlamydia pneumoniae and chlamydia psittaci from hospitalized patients in hong kong. antibodies to c. pneumoniae were found in 54.8% of 157 patients hospitalized with respiratory disease, in 71.1% of 83 patients with cardiac disease and in 31.2% of 93 patients without either respiratory or cardiac disease. antibodies to c. psittaci were found in 0.9% of the combined study groups. there was se ... | 1997 | 9259078 |
| chlamydia pneumoniae and chronic lung diseases. | chlamydia pneumoniae infection has been implicated in several chronic lung diseases by serology and direct antigen detection. acute lower respiratory tract infection caused by c. pneumoniae seems often to precede attacks of asthma in both children and adults. chlamydia pneumoniae is also involved in some exacerbations of chronic bronchitis and chronic obstructive lung disease but, more importantly, seems to be strongly associated with the latter irrespective of exacerbation status. moreover, per ... | 1997 | 9259079 |