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cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications.leprosy bacilli harvested from freshly biopsied tissue from cases of lepromatous, borderline and histoid leprosy were, in conjunction with mycobacterium lepraemurium and representative mycobacteria, examined cytochemically with and without their pyridine-extractable acid-fastness. unlike the mycobacteria, unextracted leprosy bacilli failed to give a positive response to the periodic acid schiff test or to take up sudan black b, toluidine blue o, alkaline methylene blue or safranin o. once their ...19734120605
comments on the chemotherapy of leprosy as influenced by present knowledge of mycobacterium leprae. 19734120832
electron microscopic study of the morphologic index. 19734126544
recognition of leprosy. 19734348376
implications of chemoautotrophism in mycobacterium leprae. 19734349602
immunological problems in leprosy research. 1.this memorandum reviews the present status of knowledge of the immunology of leprosy, with particular attention to developments since the publication of a similar review in 1970. the different types of lepromin reaction and their significance in healthy contacts and in patients with tuberculoid and lepromatous leprosy are discussed. the immunological responsiveness of patients with leprosy is also considered, with special attention to in vitro methods for evaluating this response. part 2 of the ...19734355402
dopa metabolism by mycobacterium leprae: its implications in culture of the bacillus and chemotherapy of leprosy. 19734207691
immune response to mycobacterium leprae in indeterminate leprosy patients. 19734209177
[experience in the experimental study of leprosy]. 19734196880
immunological reactions of mycobacterium leprae and mycobacterium lepraemurium grown in cayman. 19734197246
immunochemical characteristics and differentiation of nocardiae. 19734202913
[pathogenic mycobacteria in dermatology (author's transl)]. 19734203417
particulate nature of o-diphenoloxidase in mycobacterium leprae and assay of the enzyme by the radioisotope technique. 19734204390
a century of progress in experimental leprosy. 19734205081
effect of prior oxidation on the acid-fastness of mycobacteria. 19734129032
experimental chemotherapy in leprosy, then and now. 19734136732
leprosy-susceptibility testing of armadillos. 2. late cell and bacterial responses at inoculation site of living leprosy bacilli in 'resistant' armadillos. 19734129797
advances in the microbiology of m. leprae in the past century. 19734130571
immunologic studies on leprosy. 2. antigenic studies of mycobacterium leprae. 19734131110
analogy of mycobacterium marinum disease to mycobacterium leprae infection in footpads of mice.because it appeared likely that the disease process that follows inoculation of footpads of mice with mycobacterium marinum might serve as a useful model of mouse footpad infection with m. leprae for immunological studies. an attempt was made to establish an analogy between the two processes. as a second objective, the adequacy of measurements of mouse footpad thickness as an index of the total number of m. marinum and of the number of viable m. marinum was determined. the evolution of m. marinu ...19734594116
[differential diagnosis of mycobacterium leprae using in-vitro studies in the human macrophage]. 19734578753
[leprosy as an immunological model]. 19734570661
[mycobacterium leprae. a 100-years recollection]. 19734570663
stimulating effect of pyruvate on the growth of mycobacterium leprae in cell-free, semisynthetic, soft agar medium.a bacterial suspension prepared from a nodule from a patient with lepromatous leprosy was inoculated into the cell-free, semisynthetic, semiliquid agar medium m-y 11d-modified from the authors' medium m-y 1c by omitting glycerol and adding pyruvate-and incubated at 37 degrees c. the growth of the organism was stimulated so markedly that after about 50 weeks' incubation of the primary culture microcolonies could be seen floating in the agar layer as tiny white particles, while the medium fluid as ...19734590553
conservation of mycobacterium leprae in liquid nitrogen. 19734590989
growth inhibiting and promoting effects of amino acids and glucose of five strains of m. leprae and their growth on an inhibitor-free medium. 19734591322
advances in leprosy control in the last 100 years. 19734591732
[epidemiology of leprosy in the last 100 years]. 19734591733
gerhard henrik armauer hansen. 1841-1912. 19734592237
leprosy in norway: an interplay of research and public health work. 19734592243
assessment of the bacteriological effect of combined treatment with rifadin, sulfamethoxypyrazine, and isoniazide in lepromatous leprosy. 19734592434
[initial clinical results using new, experimentally developed therapeutic forms in leprosy]. 19734592436
leprosy in the nine-banded armandillo. 19734592437
culture study of m. leprae in mice in tropics with and without controlled environmental air temperature. 19734592488
immunology of experimental leprosy. 19734596875
the immunological spectrum of leprosy. 19734596876
lepra reactions. 19734596877
[culture and inoculation of mycobacterium leprae in tissues and organs in a state of microbiosis and necrosis]. 19734597525
ultrastructure of lepromatous nerves. neural pathogenesis in leprosy. 19734598110
[symposium on mycobacterium leprae]. 19734598383
[importance of repeated immunological stimulation using bcg in the treatment of lepromatous leprosy. new evaluation of 13 patients]. 19734599200
leprosy--its diagnosis. 19734599205
editorial: dr. gerhard hansen. 19734599206
the centenary of the discovery of the leprosy bacillus. 19734599600
armauer hansen--the man and his work. 19734601451
dapsone resistance in leprosy. 19734602407
the bacterial load in the nasal mucosa of chinese patients. 19734602638
mechanism of "reactions" in borderline tuberculoid (bt) leprosy. a preliminary report. 19734602874
subclinical infection in leprosy.lymphocyte transformation has been used to study the immune response to mycobacterium leprae among contacts and non-contacts of leprosy patients. of 26 subjects living in a leprosy endemic area for less than two months none responded to m. leprae; 24% of subjects who had lived in an endemic area for more than a year gave a positive response to m. leprae; more than 50% of individuals with occupational contact of leprosy for more than a year responded; and about 50% of contacts of tuberculoid and ...19734580217
behavior of mycobacterium leprae in human macrophages in vitro.attempts have been made to cultivate mycobacterium leprae in human macrophages in vitro. in 27 out of 55 experiments a two- to ninefold increase (mean 2.31 +/- 1.46) in acid-fast organisms were observed over a period of 1.5 to 3 months of cultivation. no such increase was observed with heat-killed bacilli (mean fold increase 0.88 +/- 0.19). macrophages were necessary for obtaining increases. no multiplication was observed on artificial media. a close correlation between increases of acid-fast or ...19734581011
how do leprosy bacilli leave the body? 19734582178
the hansen centenary. 1. hansen, bergen and leprosy. 19734582179
ulcerating lepromatous leprosy in a patient with dapsone-resistant mycobacterium leprae. 19734582180
spheroidal bodies and globi of human leprosy. 19734582380
editorial by the president of the international leprosy association. 19734582835
a rapid identification test for mycobacterium leprae. 19734582837
in vitro behavior of blood derived macrophages against killed m. leprae. 19734582838
the effect of neonatal thymectomy on mycobacterium leprae infection in mice. 19734582839
mechanism of nerve destruction in tuberculoid-borderline leprosy. an electron-microscopic study. 19734582968
immune responsiveness to mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. 19734583777
autotrophism of an "intracellular parasite" mycobacterium leprae. 19734583838
the nasal mucus in leprosy. 19734584261
lepra cells in synovial fluid of a patient with erythema nodosum leprosum. 19734585102
editorial: leprous leukoderma. 19734585247
a histological study of liver lesions in leprosy. 19734585597
acute adenopathy in a young man. 19734575466
g. armauer hansen. 19734575467
hansen's bacillus. gerhard henrik armauer hansen (1841-1912). 19734571363
the microscope and leprosy. 19734571465
effect of surface active agents and semisolid agar media on the growth of mycobacterium leprae. 19734572215
leprosy-susceptibility testing of armadillos. 1. cellular responses to intradermally inoculated heat-killed leprosy bacilli. 19734572646
the problem of cultivation of mycobacterium leprae. a review with criteria for evaluating recent experimental work.some criteria are presented to help evaluate papers appearing in the literature claiming successful cultivation of m. leprae either in the absence or in the presence of tissue-cultured cells. recently, electron microscopic studies have definitely shown m. leprae to belong to the genus mycobacterium and its division to occur through transverse section. a survey is given of the mycobacterial strains isolated in the last 10 years from leprosy lesions. these strains belong to taxonomically different ...19734212439
early response of mouse foot pads to mycobacterium laprae.the purpose of these experiments was to study the early response of mouse foot pads to mycobacterium leprae. to accomplish this, mice were inoculated in both foot pads with large and small numbers of organisms. the animals were sacrificed at intervals from 2 hr to 27 days after inoculation. the microscopical results, which utilized normal balb/c and thymectomized-irradiated b6c3f(1) mice, showed that the tissue responded first with an influx of polymorphonuclear cells and later lymphocytes and m ...19734570280
an investigation of takahashi's antitubercle phosphatide kaolin agglutination test (kat) in leprosy. 19744212936
antimycobacterial antibodies in sera from patients throughout the clinico-pathological disease spectrum of leprosy. 19744215284
[prospect of tuberculosis research. in reference to bacteriological aspect (author's transl)]. 19744218277
potential antileprotic agents. 1. inhibition of a model mycobacterial system by diaryl sulfones. 19744585972
potential antileprotic agents. 2. inhibition of mycobacterial dihydrofolic reductase. 19744585973
leprosy in the armadillo: new model for biomedical research.eight of twenty armadillos (dasypus novemcinctus l.) developed severe lepromatous leprosy 3 to 3.5 years after inoculation with viable mycobacterium leprae. a total of 988 grams of lepromas containing an estimated 15 to 20 grams of leprosy bacilli has been harvested from these animals. the large amounts of material now available will permit in-depth studies of the biochemistry and metabolism of the leprosy bacillus, and the animal model should make possible definitive studies on the immunology, ...19744589901
immunological spectra in chronic infectious diseases. 19744604571
the effect of rifampicin on mycobacterium leprae in mice. 19744605247
letter: sensitivity of mycobacterium leprae to dapsone, studied in the rat. 19744606751
the antileprotic action of clofazimine (b663, g30, 320, lamprene). 19744607163
viability of blood-borne mycobacterium leprae. 19744607341
multiple nasal smears in early lepromatous leprosy. 19744608404
the nasal dicharge in leprosy: clinical and bacteriological aspects. 19744608620
the nose in leprosy: steps to a better understanding. 19744608688
the nose in mice with experimental human leprosy. 19744608689
the transmission of human leprosy. 19744609254
the value of scrotal biopsy in leprosy. 19744609347
growth inhibitory activity of deoxyribonucleic acid-containing factor(s) isolated from lepromatous lesions.deoxyribonucleic acid-containing factor(s) isolated from mycobacterium leprae suspensions obtained from lepromas of nine patients showed growth inhibitory activity against micrococcus and both orange-red-pigmented and coccoid mutants of mycobacteria. no growth inhibition was observed for parent mycobacterial species, escherichia coli, pseudomonas aeruginosa, bacillus subtilis, and staphylococcus epidermidis.19744609913
rapid effective measure of a humoral substance(s) reacting specifically with mycobacterium leprae antigens.leprosy-specific humoral reactants were demonstrated by light scatter. of 132 lepromatous leprosy sera, 70% gave more extensive reactions than 99% of 100 normal sera.19744609914
organized nerve tissue cultures infected with mycobacterium leprae and mycobacterium lepraemurium. 19744609927
studies of the mouse foot pad technic for cultivation of mycobacterium leprae. 1. fate of inoculated organisms. 19744609928
the behavior of leprous lymphocytes and macrophages in the macrophage migration-inhibition test. 19744609929
experimental infection of the korean chipmunk (tamias sibiricus asiaticus, gmelin) with m leprae. 19744609930
[therapeutic effect of rifampicin (rfp) on leprosy. ii. on the changes of the morphological index of m. leprae in patients (author's transl)]. 19744610308
[pathomorphology of the skin and internal organs of mice in experimental infection with mycobacterium leprae cdvi strains]. 19744611091
immune responsiveness to mycobacterium leprae of healthy humans. application of the leucocyte migration inhibition test. 19744611138
leprosy. 19744611211
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