Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| corynebacterium parvum-induced resistance to a methylcholanthrene fibrosarcoma. | 1978 | 627989 | |
| modification of radiation responses of murine tumors by misonidazole (ro 07-0582), host immune capability, and corynebacterium parvum. | the hypoxic cell sensitizer misonidazole (ro 07-0582),1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol, significantly enhanced the local control of the weakly immunogenic c3h mouse mammary carcinoma mdah-mca-4 (8-mm diameter) by single doses of radiation. the dose modification factor (dmf) was 2.33 when the drug was given ip to inbred c3hf/bu mice in a dose of 1 mg/g body weight 30 minutes before irradiation of the tumor. the dmf in a highly immunogenic 3-methylcholanthrene-induced c3h fibrosarcoma ... | 1978 | 633396 |
| immunotherapy of cancer with corynebacterium parvum. | 1978 | 637374 | |
| comparative studies of porphyrin production in propionibacterium acnes and propionibacterium granulosum. | porphyrin production by propionibacterium acnes and that by propionibacterium granulosum were compared. porphyrin synthesized by both organisms was identified as coproporphyrin iii on the bases of absorption and fluorescence spectra and behavior on paper chromatography and thin-layer chromatography. quantitative, rather than qualitative, differences in production were found between these organisms. in general, p. granulosum produced significantly greater amounts (p less than 0.001) of porphyrin ... | 1978 | 637914 |
| studies with a spontaneous mouse tumor. i. growth in normal mice and response to corynebacterium parvum. | growth of isogeneic transplants of a spontaneous murine adenocarcinoma, which is virtually devoid of tumour-specific transplantation antigens, is inhibited by i.v. injection of c. parvum 3 days after tumour inoculation, or by mixing a small dose of c. parvum with the tumour inoculum. moreover, the therapeutic effect of cyclophosphamide, followed by i.v. or i.p. injection of c. parvum 5 days later, on established transplants of the same tumour is greater than that of cyclophosphamide alone. these ... | 1978 | 638014 |
| endophthalmitis caused by propionibacterium acnes. | we treated a man who developed endopthalmitis six weeks after a seemingly minor injury. cultures were positive for propionibacterium acnes, an anerobic, gram-positive rod that is a normal inhabitant of the conjunctiva but is rarely a cause of endophthalmitis. the patient underwent vitrectomy and lensectomy with intravitreal injection of antibiotics followed by systemic cephalothin and prednisone. clinical and visual improvement was rapid. | 1978 | 638845 |
| phase i studies of c. parvum given intravenously: effects of dexamethasone on its biologic and toxic properties. | three biologic effects were clearly associated with c. parvum infusions: a) granulocytosis with lymphomonocytopenia, b) increase in responsiveness to phytohemmagglutinin and c) increase of specific antibodies to c. parvum antigens. addition of dexamethasone moderately altered the kinetics of leukocyte changes without affecting other properties. side effects after intravenous administration of c. parvum (2.5 mg/m2) consisted primarily of chills and fever which lasted for periods of 6-24 hours. s ... | 1978 | 638994 |
| thymoindependent antigentic stimulation in nude mice: response to polyvinylpyrrolidone and adjuvant effects of corynebacterium parvum and lh1. | the humoral thymoindependent response to polyvinylpyrrolidone (pvp) measured by the farr test, was not different in athymic nude and phenotypically normal mice. in athymic and normal mice, this response was significantly increased by cornebacterium parvum administered at the time of immunization. a recently synthetized compound, lh1 (3alpha-n-[2 aminoethanol]-amino 5-alpha-pregnane-20-one) was, however, a better immunostimulant of the anti-pvp response in athymic mice. | 1978 | 640744 |
| effects of amputation and corynebacterium parvum on tumour metastases in mice. | the effects of operation (lower-limb amputation) on the growth of the lewis lung tumour and its metastases were studied. the role of c. parvum in counteracting these effects was investigated. anaesthesia alone or with amputation did not affect primary tumour growth. c. parvum depressed this growth. anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. c. parvum inhibited metastases and completely counteracted the effects of operation on them ... | 1978 | 646927 |
| corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats. | 1978 | 646934 | |
| decreased hepatic drug demethylation in patients receiving chemo-immunotherapy. | the effect of immunotherapy and chemotherapy on hepatic n-demethylation of aminopyrine was studied by means of the aminopyrine breath test (abt) in 32 patients with cancer. the aminopyrine breath test (abt) was decreased in 3 of 11 patients (27.3%) receiving intradermal bcg (+/- dtic) at a dose of 3 x 10(7) viable organisms. one of 4 (25%) patients receiving intradermal bcg (+/- dtic) at 3 x 10(8) viable organisms per dose developed an altered abt. changes were not seen in patients receiving aer ... | 1978 | 647621 |
| monocyte function in patients with solid neoplasms during immunotherapy with corynebacterium parvum. | the present studies were performed in order to evaluate monocyte function in patients with solid neoplasms before and after administration of c. parvum. the results demonstrate that monocytes from cancer patients display increased numbers of c3 and fc receptor sites after administration of c. parvum. it is concluded that characterization of monocyte receptor activity may be helpful in monitoring the effects of immunotherapy in the immune system. | 1978 | 647625 |
| induction of spleen cell growth and dna polymerase activity by corynebacterium parvum. | corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in dna synthesis as measured by [3h]thymidine uptake and increase in dna polymerase activity. cell number increased exponentially over 10 days. dna polymerase activity increased 8-fold after c. parvum stimulation. the rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by c. parvum. | 1978 | 647675 |
| effect of aerobic and anaerobic corynebacteria on reaginic antibody response in mice. | 1978 | 661628 | |
| radiation-induced inhibition of splenocyte locomotion and its protection by c. parvum. | 1978 | 663069 | |
| prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas. | 1978 | 663826 | |
| nephrotoxicity from cancer immunotherapy. | because systemic intravenous immunotherapy with corynebacterium parvum is an effective immunopotentiating and immunotherapeutic agent in animals, clinical studies of this agent have been undertaken. toxicities in man have been noted, but most are treated symptomatically. three patients with metastatic melanoma developed oliguria, edema, diffuse bilateral pulmonary infiltrates, azotemia, hypoalbuminemia and hypocomplementemia, while receiving intravenous c. parvum therapy. all had renal biopsies ... | 1978 | 666183 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. iii. tumor growth inhibition by local delayed hypersensitivity reactions to unrelated antigens. | delayed hypersensitivity (dh) reaction to human ig, corynebacterium parvum or allogeneic cells at the site of tumor cell injection, suppressed the fibrosarcoma (scfs) growth in chickens. spleen cells of sc chickens sensitized to human ig or c. parvum suppressed scfs growth when adoptively transferred with tumor cells, but only when the sensitizing antigen was present locally. this suppression did not occur in irradiated recipients, scfs i cells injected into wattles of chickens immune to the tum ... | 1978 | 668800 |
| response of malignant melanoma to plasma exchange, surgical debulking, and corynebacterium parvum. | a 48 year old man with extensive cutaneous and subcutaneous metastatic malignant melanoma responded to treatment by repeated plasma exchanges, partial surgical debulking of tumor masses, and intravenous corynebacterium parvum. circulating immune complexes were measured by the serum c1q binding method. tumor regression coincided with serum c1q binding reduction to normal levels. clinical relapse was preceeded by recurrent elevation of serum c1q binding activity. | 1978 | 669835 |
| effects of corynebacterium parvum and cortisone on the primary lewis tumour and its metastases. | the effects of corynebacterium parvum and cortisone acetate (ca) on the primary lewis lung carcinoma and its pulmonary metastases were investigated. c. parvum given iv either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg ca (high-dose) given sc 4 and 11 days after tumour, alone or in combination with c. parvum, administered on day 0, reduced primary tumour growth to the same extent as c. pravum alone. high-dose ca given on days 2 and 6 had no eff ... | 1978 | 669856 |
| induction of interferon in mice injected with heat-killed corynebacterium anaerobium. | 1978 | 671815 | |
| electrophoretic protein patterns and enzyme mobilities in anaerobic coryneforms. | the soluble protein patterns and electrophoretic mobilities of malate and succinate dehydrogenases and catalase have been examined in 25 strains of propionibacterium acnes, p. granulosum, and p. avidum. a distinctive protein pattern for each species was found, and it was possible also to distinguish the serotypes within p. acnes and p. avidum. strains of p. acnes, p. granulosum, and p. avidum could be differentiated by the mobilities of their malate dehydrogenases. catalase activity was detected ... | 1978 | 677876 |
| anaerobic flora of the normal human conjunctival sac. | specimens from the conjunctival sacs of 92 healthy eyes were cultured on two separate occasions to determine the presence or absence of a persistent anaerobic flora. aerobic bacteria and fungi were also studied for comparison. of the 184 eye cultures, 112 (60.9%) contained at least one microorganism. obligate anaerobes were recovered from 51.6% (95/184) of the cultures. propionibacterium acnes, the predominant anaerobe encountered, was present in 49.5% (91/184) of the eyes. aerobic and facultati ... | 1978 | 678185 |
| coagulation and fibrinolysis during the infusion of corynebacterium parvum in man. | 1978 | 678428 | |
| effect of corynebacterium parvum on the proliferative rate of granulocyte-macrophage progenitor cells and the toxicity of chemotherapy. | we have studied the interaction of corynebacterium parvum and a variety of cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents on granulocyte-macrophage progenitor cells [colony-forming units culture (cfu-c)] in c57bl/6 mice. in vitro tritiated thymidine suicide studies showed an increased rate of proliferation of bone marrow cfu-c 24 hr after c. parvum injection. in vivo toxicity of cell cycle-specific agents but not of cell cycle-nonspecific agents for bone marrow cfu-c was ... | 1978 | 679169 |
| comparison of the inhibition of tumor growth following local or systemic administration of corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. | 1978 | 679170 | |
| rate of tumour inhibition by activated macrophages in vitro. | 1978 | 679868 | |
| cytotoxic activity of human blood monocytes against cultured breast cancer cells. | cytotoxic activity of blood monocytes from 19 healthy individuals was examined in vitro against the cultured floating cells of human breast cancer origin. target tumor cells inoculated on monocyte cultures and maintained for 5 days were reduced in number, compared with the control cultues of tumor cells alone. increased cytotoxicity of the monocytes was noted after in vitro activation by heat-killed corynebacterium liquefaciens (propionibacterium acnes). c. liquefaciens of the same dose as used ... | 1978 | 680464 |
| interferon production and lymphocyte stimulation in human leucocyte cultures stimulated by corynebacterium parvum. | killed c. parvum organisms stimulated a lymphoproliferative response in human peripheral leucocyte cultures of both adult and cord blood origin. they also induced high titres of interferon in cultures of adult leucocytes, but there was no correlation between the degree of lymphocyte stimulation and of interferon production. a considerable variability between donors was seen in both assays. the amount of interferon produced in c. parvum-stimulated cultures was considerably higher than that stimul ... | 1978 | 688696 |
| in vitro activity of tiamulin (81.723 hfu), a new pleuromulin derivative, against clinically significant anaerobes. | the susceptibility of more than 40 strains of gram-negative and gram-positive anaerobes to tiamulin (sandoz 81.723 hfu), a new pleuromulin (pleuromutilin) derivative, was determined by broth dilution and agar dilution tests. the influences of density of the inoculum upon mics was studied by a specially designed pour plate-technique. bacteroides fragilis, b. vulgatus, b. splanchnicus, b. oralis, b. asaccharolyticus, b. melaninogenicus, fusobacterium fusiforme (f. nucleatum), sphaerophorus necroph ... | 1978 | 690009 |
| preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: effect on intracranial pressure. | it has been observed that patients with metastatic brain lesions developed neurologic symptoms when given corynebacterium parvum. to obtain more information in patients with intracranial mass lesions, intracranial pressures (icp) were measured or observed in six patients undergoing c. parvum therapy. all patients except two (one previously shunted, one recently operated) demonstrated a profound increase in icp. it is presumed that either edema is formed within brain and tumor tissue (inasmuch as ... | 1978 | 692136 |
| immunoproliferative alterations in lymphoid tissues and liver in mice stimulated with corynebacterium parvum. | morphological alterations in the spleen, liver, lymph nodes, thymus, bone marrow and blood were studied in dba and balb/c mice treated with corynebacterium parvum. the spleen lymph nodes and liver increased in size and weight, whereas thymus showed decrease in weight compared to the control group. a marked, early proliferation of monocytes in the bone marrow preceded infiltrations by macrophages in lymph nodes, spleen and liver. these infiltrations were closely related to the vascular structures ... | 1978 | 696333 |
| failure of preoperative c. parvum vaccine to modify secondary disease following excision of two non-immunogenic murine carcinomas. | sadler and castro (1976) reported that a single dose of c. parvum vaccine given i.p. or i.v. to mice 4 days before excision of subcutaneous transplants of lewis lung carcinoma significantly reduced the incidence of lung metastases in the operated mice. in similarly designed experiments, using 2 different carcinomas of spontaneous origin in our own inbred mouse colonies, we were unable to demonstrate any influence of c. parvum vaccine on the incidence or latent period of secondary disease in oper ... | 1978 | 698036 |
| bacteriologic examination of autologous blood. | 1978 | 705401 | |
| a preliminary study of intralesional, intralymph node, intravenous and intraperitoneal corynebacterium parvum treatments in patients with advanced cancer. | twenty-one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2-4 mg/m2) and intralymph node (2-4 mg/m2) c. parvum injections followed by 5 intravenous (2-4 mg/m2) c. parvum treatments and conventional therapies. seven patients with stage iii ovarian carcinomas were given intraperitoneal (2-4 mg/m2) c. parvum injections followed by conventional therapies. the local and systemic effects of the c. pa ... | 1978 | 709538 |
| combined radiotherapy and corynebacterium parvum treatment of rat tumors with different immunogenicity. | 1978 | 711536 | |
| lysozyme levels and macrophage content of tumor tissue in c3h mice bearing fibrosarcoma transplants treated by radiation and corynebacterium parvum. | 1978 | 711553 | |
| bacteriological investigation on biopsy specimens from patients with sarcoidosis. | biopsy specimens, mostly lymph nodes, removed under aseptic conditions, were emulsified and the homogenate was inoculated in various media, which were incubated aerobically or anaerobically. only propionibacterium acnes was isolated in high incidence and the highest concentration of bacteria was 6.5 x 10(5) per g tissue: 28 and 31 out of 40 lymph nodes were positive on solid and on liquid media, respectively. p.acnes was also isolated from control non-sarcoidosis lymph nodes: 4 and 8 out of 14 w ... | 1978 | 713130 |
| characterization of propionibacterium acnes isolated from biopsy specimens obtained from patients with sarcoidosis. | 1978 | 713132 | |
| pigment vs cholesterol cholelithiasis: bacteriology of gallbladder stone, bile, and tissue correlated with biliary lipid analysis. | 1978 | 717347 | |
| toxicity manifestations following intravenous corynebacterium parvum administration to patients with ovarian and cervical carcinoma. | manifestations of clinical toxicity were evaluated following 341 courses of intravenous corynebacterium parvum adjuvant immunotherapy in patients with ovarian and cervical carcinoma. most patients exhibited symptoms of minor toxicity, which decreased in intensity as subsequent courses of therapy were administered. temperature elevations to 38.5 degrees c. were the most objectively measured signs of toxicity but temperature elevations greater than 38.5 degrees c. occurred following only 20.5 per ... | 1978 | 717456 |
| destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762a by treatment with corynebacterium parvum. | intratumoral administration of corynebacterium parvum to 13762a tumor-bearing rats on day 7 of tumor growth, followed by primary tumor excision on day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. rats treated by surgery alone on either day 7 or day 20 died with metastases to axillary lymph nodes and lungs. tumor was established in axillary lymph nodes by day 7. therefore, intratumoral injection of c. parvum on day 7 destroyed metastases alre ... | 1978 | 719637 |
| positive 67ga-citrate scans in patients receiving corynebacterium parvum. | gallium-67 citrate imaging for the staging of lymphomas was performed in three patients receiving corynebacterium parvum (c. parvum) immunotherapy. unexpected uptake at the site of c. parvum injections was identified and although the mechanism of localization is not determined by this study, similarities between c. parvum's known actions and the postulated mechanism of 67ga-citrate localization are compared. | 1978 | 719980 |
| immune prophylaxis of experimental cancer by corynebacterium parvum. | fractionated administration of c.p. i.v. in mice at risk from sarcomas after injection of 0.2 mg mca leads to a significant prolongation of the period of latency under certain circumstances. experimental groups which have received the immune stimulator for 6 weeks immediately after the cancerogenic factor show the best results. after tumour manifestation there is no perceptible preventive effect of c.p. | 1978 | 720440 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide--viii. | 1978 | 721660 | |
| electron capture gas-liquid chromatographic study of metabolites produced by some arthritic transudate-associated organisms in vitro and in vivo in rabbit models. | computerized, frequency-pulsed, modulated electron capture gas-liquid chromatography was used to study the acid metabolites produced in vitro in fetal calf serum and in vivo in an animal chamber model. several strains of diplostreptococcus agalactiae, propionibacterium acnes, staphylococcus aureus, and streptococcus serogroups a, b, and g were studied. all of these organisms have been reported to be associated with arthritic transudates in humans. metabolites were detected by this method from de ... | 1978 | 721944 |
| differential susceptibility of propionibacterium acnes, p. granulosum and p. avidum to free fatty acids. | the susceptibility of 98 propionibacterium acnes, p. granulosum and p. avidum strains isolated from acne cases and appropriate reference strains to decanoic, dodecanoic, octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids was investigated using minimal inhibitory concentration estimation by an agar dilution techique. the tested acids showed their relative antibacterial activity in the following order: c18:3 delta 9,12,15 greater than c18:2 delta 9,12 greater than c12:0 greater than c10:0 ... | 1978 | 722112 |
| propionicins, bacteriocins produced by propionibacterium avidum. | one hundred strains of propionibacterium acnes, granulosum and avidum were tested for susceptibility toward bacteriocins produced extracellularly by eight strains of propionibacterium avidum. some bacteriocin-producing strains were inhibitory for all strains tested. a name propionicins, is proposed for bacteriocins produced by p. avidum. | 1978 | 726736 |
| effect of glucan and other adjuvants on the clearance of radiolabeled tumor cells from mouse lungs. | the iv injection of two forms of glucan (diluzio and yamamura), corynebacterium parvum, or bacillus calmette-guérin (bcg) caused a significant increase in the rate and extent of clearance of subsequently injected radiolabeled t1699 carcinoma cells from the lungs of syngeneic dba2 mice. dose-response curves were obtained for each agent, the relative rates of clearance of radiolabeled cells were established, and preliminary sequential comparative studies were undertaken. the optimum dose for c. pa ... | 1978 | 728905 |
| comparative effects of corynebacterium parvum, brucella abortus extract, bacillus calmette-guérin, glucan, levamisole, and tilorone with or without cyclophosphamide on tumor growth, macrophage production, and macrophage cytotoxicity in a murine mammary tumor model. | in this laboratory, it has been repeatedly demonstrated (using a murine mammary tumor model) that the combination of cyclophosphamide (cy) and corynebacterium parvum (cp) is more effective than either agent alone in the control of tumor growth. this paper presents information obtained in our model comparing findings on the effects of cp with a brucella abortus extract (bru-pel; bp) and glucan (gl) on tumor growth. in addition, the influence of those agents as well as bacillus calmette-guérin, ti ... | 1978 | 728912 |
| effect of topical application of dexamethasone on propionibacteria in the pilosebaceous duct. | a preparation of dexamethasone 0.02% in eutanol g (n octyldodecanol) was applied once daily for three weeks, to the right side of the forehead of 25 male healthy test subjects. eutanol g without dexamethasone was applied in the same way to the left side of the forehead. before and at the end of the treatment period bacteria were removed from the pilo-sebaceous ducts by the method of holland et al. [8]. bacteria that grew under anaerobic conditions were evaluated quantitatively. dexamethasone ind ... | 1978 | 729607 |
| saprophytic bacterial flora in the sebaceous gland infundibulum in diabetes mellitus. | 1978 | 736608 | |
| propionibacteria as a cause of shunt and postneurosurgical infections. | propionibacterium acnes was isolated from postoperative specimens from nine neurosurgical patients. the role of p. acnes in postneurosurgical infection is discussed. | 1978 | 739055 |
| studies on putative adult worm-derived vaccines and adjuvants for protection against schistosoma mansoni infection in mice. | intraperitoneal transfer of viable adult worms of schistosoma mansoni did not confer protection against a challenge infection to recipient mice. antigens of schistosome origin were evaluated for their ability, with and without concomitantly administered nonspecific adjuvants, to stimulate protective immunity against s. mansoni. freshly perfused ground worms or a putative membrane antigen extracted with 0.5 m kc1 from adult worms, when injected together with corynebacterium parvum (or in a single ... | 1978 | 739318 |
| purification and properties of a bacteriocin-like substance (acnecin) of oral propionibacterium acnes. | propionibacterium acnes cn-8, isolated from human dental plaque, was grown in a liquid medium, and its bacteriocin-like substance (acnecin) was extracted from the cells by ultrasonic treatment. acnecin was purified to a homogeneous state with recovery of 47%. specific activity increased 72-fold in comparison with the crude extract. the properties of acnecin were as follows. (i) acnecin may consist of five subunits with a molecular weight of about 12,000. (ii) its isoelectric point was 5.5. (iii) ... | 1978 | 742876 |
| a bladder tumor model response to immunotherapy. | the author presented results of bcg and corynebacterium parvum treatment of the transplantable mouse fanft bladder tumor carried in the host's leg. a comparison was made of the results of treatment with bcg alone and c. parvum alone or either used in conjunction with cytoxan upon effectiveness in increasing animal survival and retarding tumor growth. | 1978 | 748789 |
| local corynebacterium parvum therapy in early breast cancer: a pilot study. | 1978 | 750126 | |
| studies on resistance to marek's disease tumorigenesis: effect of immune stimulation, tumour-cell vaccines, and herpesvirus of turkeys on tumour immunity. | 1978 | 751899 | |
| natural killer cells may be the only cells in normal mouse lymphoid cell populations endowed with cytolytic ability for antibody-coated tumour target cells. | mouse normal lymphoid cells were analysed as to their ability to perform in three cytolytic systems: ability to act as 'natural killer', nk, cells against a nk sensitive tumour target, yac; as effector cells against igg-coated 815 cells, or to function as effector cells against igg-coated crbc. nk activity and adcc against the igg-coated p815 cells were found to vary in parallel as affected by age, organ distribution and genotype of the effector cells. on the other hand, adcc against crbc was la ... | 1978 | 418499 |
| immunotherapy from malignant disease. | 1978 | 348035 | |
| some examples of interactions between drugs in cancer chemotherapy. | drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ... | 1978 | 348085 |
| combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer. | seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ... | 1978 | 350388 |
| chemo-immunotherapy for unresectable bronchogenic carcinoma. | seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ... | 1978 | 350397 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. | 1978 | 354799 | |
| combination chemoimmunotherapy for extensive non-oat cell lung cancer. | in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ... | 1978 | 356968 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation. | the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ... | 1978 | 363250 |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| altered toxicity of 5-fluorouracil following treatment with corynebacterium parvum. | recent studies have demonstrated that systemic corynebacterium parvum increases serum granulocyte-macrophage colony-stimulating factor and stimulates the proliferation of granulocyte-macrophage progenitor cells. it was hypothesized that more rapid cycling of granulocyte-macrophage progenitor cells would render the cells more sensitive to a cell cycle-specific chemotherapeutic agent. the colony-forming ability of bone marrow granulocyte-macrophage progenitor cells was assayed in vitro with soft a ... | 1978 | 304762 |
| [the so-called adjuvant corynebacterium parvum]. | 1978 | 304802 | |
| colony stimulating and inhibiting activities in mouse serum after corynebacterium parvum-endotoxin treatment. | 1978 | 304892 | |
| suppression of rat t cell proliferation by corynebacterium parvum: t cell requirement for induction. | 1978 | 304893 | |
| bacteriocin (acnecin) activity of oral propionibacterium acnes. | 1978 | 291496 | |
| immune function determination in patients with bladder cancer. | patients with bladder cancer were evaluated clinically for immune responsiveness and stage of disease. a battery of tests is described that attempts to correlate stage of disease with immune responsiveness. | 1978 | 311893 |
| synergistic lysis of erythrocytes by propionibacterium acnes. | sheep and human erythrocytes, partially processed by staphylococcus aureus or clostridium perfringens, were susceptible to lysis in the presence of propionibacterium acnes. p. acnes liberated a lipase that was detected on tween 80 agar and also on phospholipase c-precipitated egg yolk agar. such a lipase might have contributed in the process of an intensified cellular lysis. similar reactions were attempted with lactobacillus acidophilus, known to possess a nondiffusible lipase, and failed to pr ... | 1978 | 212450 |
| protection of mice against viral infection by corynebacterium parvum and bordetella pertussis. | mice could be significantly protected against infection with herpes simplex virus (hsv) by i.p. or i.v. injection of killed corynebacterium parvum 7 days before infection. this protection was seen in inbred strains of mice with a different degree of sensitivity to hsv and after both i.p. and i.v. infection. resistant mice immunosuppressed by x-irradiation and showing an increased susceptibility to hsv could also be protected by a previous injection of c. parvum. elevated levels of interferon wer ... | 1978 | 212522 |
| defective in vitro lymphoproliferative responses to herpes simplex virus in patients with frequently recurring herpes infections during the disease-free interval. | 1978 | 213220 | |
| peritoneal macrophage activation indicated by enhanced chemiluminescence. | a number of studies have demonstrated the ability of various bacterial preparations, protozoa, and chemicals to activate macrophages and concomitantly to enhance host resistance to both tumors and infections. recently, viral infections have been shown to have a similar effect upon macrophage function. to better define the metabolic state of activated macrophages, we have evaluated the ability of peritoneal cells (pc) from vaccinia virus- or murine cytomegalovirus-infected or corynebacterium parv ... | 1978 | 213391 |
| effect of silver nitrate application on the conjunctival flora of the newborn: and the occurrence of clostridial conjunctivitis. | newborn conjunctival cultures were obtained from 35 babies prior to silver nitrate application and 48 hours later. on initial culture, 46 facultative bacteria and 27 anaerobes were recovered; 48 facultative and 18 anaerobes were recovered after 48 hours. haemophilus vaginalis, bacteroides species and anaerobic cocci decreased in numbers, whereas s. epidermidis, micrococcus and propionibacterium acnes increased during this time interval. clostridial species were isolated from two cases who develo ... | 1978 | 216788 |
| combined use of local irradiation and corynebacterium parvum in the treatment of the murine line 1 lung carcinoma. | 1978 | 204955 | |
| binding of microorganisms to the macrophage plasma membrane; effects of enzymes and periodate. | the nature of the binding of c. parvum organisms to the surface of glass-adherent mouse peritoneal exudate cells in vitro was studied using pretreatment of the cells with various enzymes and periodate. trypsin, pronase, beta-galactosidase, phospholipases a, c and d and periodate all caused a decrease in binding to 40-60% of untreated control. neuraminidase led to a 30% increase in binding. the binding ability returned to normal after 1 h at 37 degrees in culture medium following exposure to all ... | 1978 | 205234 |
| enhanced resistance against junin virus infection induced by corynebacterium parvum. | the effects of intraperitoneal administration of corynebacterium parvum on the course of junin virus infection in mice were investigated. this treatment produced enhanced resistance to the virus infection, evidenced by an increase in both survival times and the proportion of survivors. the protective effect was dependent upon the dose of c. parvum, and 280 mug/g of body weight was found to be the optimal dose. in various experiments, about 80% of the infected animals receiving this dose survived ... | 1978 | 205508 |
| effects of corynebacterium parvum on murine myeloid leukaemia. | the effects of c. parvum on rfm/un myeloid leukaemia were studied. mice inoculated with 7.0 mg but not 0.7 mg c. parvum i.p. survived significantly longer than untreated leukaemic mice (p less than 0.001). administration of silica abrogated the effects of c. parvum, whilst polyvinyl pyridine-n-oxide prevented the inhibitory effects of silica. these studies demonstrate that a single large dose of c. parvum, either before or after leukaemic-cell passage, can significantly prolong the survival of r ... | 1978 | 217398 |
| liver abscess in normal children with fever of unknown origin. | 1978 | 263854 | |
| tumor immunology of experimental osteosarcoma. | a spontaneous ap positive c3h murine os was used to determine the effects of various treatment modalities. ap served as a useful circulating biomarker of the in vivo tumor growth. in animals whose tumor was amputated, the elevation of the marker indicated the presence of pulmonary metastases. it was used to establish the time of recurrence after a partially effective chemotherapy or combination modality. in this model, when the neoplasm was surgically excised at 10 days posttransplantation, 70-- ... | 1978 | 278687 |
| effect of corynebacterium parvum on tumor growth in the central nervous system of mice. | 1978 | 278860 | |
| propionibacterium acnes-mediated humoral immune responses to tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens. | effects of propionibacterium acnes on production of antibodies against tumor-specific membrane antigens were investigated in syngeneic inbred bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells for tumor-specific antigens. by membrane immunofluorescence, antibodies against these rat liver cell lines were detected in syngeneic bd rat sera. antibodies were produced in syngeneic rats under the adjuvant effect of heat-killed p. acnes o ... | 1978 | 281560 |
| [dandruff (pityriasis simplex capillitii)]. | in this review of new studies about dandruff, methods for clinical (subjective) evaluation and quantitative (objective) appraisal of dandruff are described. current concepts about histopathology, cytology, biochemistry and etiopathogenesis of this common condition of the scalp are detailed. | 1978 | 149094 |
| effect of propionibacterium acnes or bcg on enzyme activities in spleen lymphocytes of donryu strain rats. | immunopotentiated rats, which were injected with propionibacterium acnes or bcg, had the 50% survival twice as long as those in untreated controls after intravenous inoculation of sato lung carcinoma (slc) cells. the amount of labeled tumor cells in the lung of the adjuvant-treated rats decreased significantly in the first 20 hr after intravenous injection of 51cr-labeled tumor cells compared to that of control animals. the elevated activities of atpase and acid phosphatase in the whole nucleate ... | 1978 | 149684 |
| an analysis of conditions allowing corynebacterium parvum to cause either augmentation or inhibition of natural killer cell activity against tumor cells in mice. | we have analyzed the impact of in vivo administration of corynebacterium parvum on the mouse immune system against murine tumors, using the natural cytotoxic ability against tumors of normal mouse lymphoid cells as a baseline. a striking difference was found depending on the route of administration. intravenous inoculation of bacteria would result in a significant decrease or sometimes complete abolition of natural cytotoxicity toward tumor cells of the spleen cells of treated mice. on the other ... | 1978 | 149772 |
| cellular immunity to p. acnes in the normal population and patients with acne vulgaris. | patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to p. acnes using a leukocyte migration inhibition test. despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. it is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation. | 1978 | 150284 |
| on the propionibacteria in the pilosebaceous ducts of uninvolved skin of acne patients. | in 24 persons with a severe inflammatory acne and 48 control subjects, bacteria were sampled from the sebaceous gland exretory ducts with the glass sampling head method according to holland et al. after anaerobic culture bacterial counts were performed. the total numbers of p. acnes and the frequency of detection of p. granulosum were determined. the bacterial counts of p. acnes were almost idendical in the two collectives. p. granulosum was detected at a significantly higher frequence in the ac ... | 1978 | 150822 |
| dermatology: acne vulgaris. | 1978 | 150871 | |
| nutritional requirements of anaerobic coryneforms. | the nutritional requirements of three species of anaerobic coryneforms and their serotypes (propionibacterium acnes types i and ii, p. avidum types i and ii, and p. granulosum) were determined. strains of p. avidum would consistently grow to a transmittance of 1 to 3% at 560 nm in a basal salts medium supplemented with glucose, pantothenate, biotin, thiamine, and 12 amino acids (alanine, arginine, cysteine, glutamine, glycine, histidine, isoleucine, methionine, phenylalanine, serine, tyrosine, a ... | 1978 | 151095 |
| ultrastructural basis for the assay of topical acne treatments. transmission and scanning electron microscopy of untreated comedones. | after two decades of using systemic antibiotics as a main treatment for acne, emphasis is again being placed on topical agents. thus, it is highly desirable to have a procedure whereby the activity of the various compounds can be evaluated by direct visualization. scanning electron microscopy combined with transmission electron microscopy provide the tools for such in assay. this study describes the ultrastructure of untreated comedones and provides the baseline or control data necessary for tes ... | 1978 | 151693 |
| the chemoattractant properties of comedonal components. | acculation of clusters of polymorphonuclear leukocytes (pmn) along the periphery of the walls of comedones (predominantly of the closed variety), has been described as the first change marking the transition of quiescent, noninflamed lesions in acne, into inflammatory ones. the present study analyzed the chemoattractant properties of different comedonal components for human pmn in an effort to evaluate the potential significance of these substances in stimulating the chemotactic response of pmn ... | 1978 | 152335 |
| analysis of the water soluble extract of comedones. | the water soluble fraction of 713 open comedones, pooled from both the face and back of 47 subjects representing all grades of acne, were analyzed for total protein content, carbohydrate content, and for identification of specific proteins. in the water soluble fraction, the protein content represented 11.5%, and carbohydrate content 0.2% of the total comedonal crude weight. esterase and hyaluronidase activity was demonstrated. propionibacterium acnes antigenic material, serum albumin, and serum ... | 1978 | 152336 |
| hepatic arterial infusion of corynebacterium parvum and chemotherapy. | 1978 | 152477 | |
| prostaglandin-like substances in propionibacterium acnes. | 1978 | 152714 |