Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| new experimental and clinical data on leukaemia immunotherapy. | the present results of our treatment of acute lymphoid leukaemia patients are summarized: 7 out of 20 randomized patients given active immunotherapy after chemoradiotherapy are still in complete remission after periods varying from seven to ten years (compared to none in the control group). the actuarial results on 100 patients show remission and survival curves presenting a plateau between three and five years for a certain percentage, suggesting a possible cure. several parameters studied in 2 ... | 1975 | 1060146 |
| proceedings: influence of cornyebacterium parvum and of anti-lymphocyte serum (als) on bone marrow transplantation in small rodents. | 1975 | 766804 | |
| level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes. | dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ... | 1975 | 816253 |
| [taxonomic position of oral anaerobic diphtheroid group (author's transl)]. | 1975 | 1074278 | |
| mechanisms of macrophage activation by corynebacterium parvum. ii. in vivo experiments. | 1975 | 1079165 | |
| daily intravenous infusions of corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings. | twenty terminally ill patients with various disseminated tumors were treated with daily iv infusions of corynebacterium parvum given alone at doses of 4 mg/day, 5 days/week, for 4-16 weeks. in 8 patients (40%), the lesions partially regressed to less than 50% of their original size. another patient who did not improve with c. parvum therapy had a complete remission after the first course of chemotherapy. skin tests, total leukocyte counts, and t- and b-cell counts revealed variable and unpredict ... | 1975 | 1080521 |
| effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma. | local injection (i.e. injection at the site of tumour inoculation) of strains of c. parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact cba mice but has little or no effect on subcutaneous transplants of the same tumour in t-cell deprived mice. the anti-tumour effect of local injection of c. parvum, unli ... | 1975 | 1080671 |
| active specific immunotherapy of mouse methylcholanthrene induced tumours with corynebacterium parvum and irradiated tumour cells. | the relative efficiency of active nonspecific or specific immunotherapy of developing methylcholanthrene induced fibrosarcomata with c. parvum was compared. for nonspecific immunotherapy, mice were challenged with tumour cells s.c. or i.v., and 2 days later injected i.v. with dilutions of c. parvum. the only significant effect was a retardation of s.c. tumour growth by the highest concentration of c. parvum (350 mug). however, active specific immunotherapy, using mixtures of c. parvum and irradi ... | 1975 | 1082344 |
| further observations on the diagnosis cause, and treatment of endophthalmitis. | in our study of 54 suspected cases of endophthalmitis, vitreous aspiration was more sensitive in making a culture-proven diagnosis than anterior chamber paracentesis; staphylococcus epidermidis was a more common cause of endophthalmitis than previously appreciated; and intraocular antibiotics in the recommended dosage are reasonably safe clinically and add a new dimension to the treatment of endophthalmitis. | 1976 | 1082716 |
| immunotherapy: concepts and nursing implications. | concepts of immunlogy and the human immune system are essential for an understanding of the rationale of immunotherapy. immunotherapy is presently being investigated as adjunct therapy for patients with cancer. it is therefore essential for the professional nurse to become cognizant of the various modalities and possible complications of immunotherapy in order that the nursing implications may be incorporated into clinical practice. | 1976 | 1083016 |
| the accumulated effects of repeated systemic or local injections of low doses of corynebacterium parvum in mice. | the effects of 14 weekly injections, s.c. or i.v., of "human equivalent" doses (5.25 mg/sq m) of corynebacterium parvum (cp) in mice have been compared. both s.c. and i.v. cp caused significant splenomegaly and antibody to cp, but stimulation was considerably greater after i.v. cp. delayed hypersensitivity levels to cp were similar after s.c. and i.v. injection. t-cell competence, as judged by phytohemagglutinin reactivity and delayed hypersensitivity to sheep cells, was unimpaired after s.c. cp ... | 1976 | 1083289 |
| effect of corynebacterium parvum on cellular and humoral antitumoral immune effector mechanisms. | 1976 | 1083341 | |
| the effect of corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer. | corynebacterium parvum, a gram-positive anaerobic bacillus thought to be a strong immunological stimulant, has been shown to decrease tumour growth and prolong survival in patients with metastatic disease. study of the effect of a single injection of a strain of c. parvum (cn. 6134) in six patients with stage iv metastatic breast cancer is reported. results of laboratory tests to judge the physical and immunological effects of the drug infusion 24 hr post-treatment and weekly thereafter for 3 we ... | 1976 | 1084821 |
| abrogation of the anti-metastatic activity of c. parvum by antilymphocyte serum. | 1976 | 1086096 | |
| mechanisms of antitumor action of corynebacterium parvum: replicating short-lived t cells as the mediators of potentiated tumor-specific immunity. | 1976 | 1086362 | |
| lactate metabolism in propionibacterium pentosaceum growing with nitrate or oxygen as hydrogen acceptor. | when anaerobic cultures of propionibacterium pentosaceum were shifted to low dissolved-oxygen concentration (d.o.c.), acetate production from lactate diminished and propionate production stopped, whereas pyruvate accumulated and oxygen was consumed. assuming that energy is generated in the electron transfer to oxygen, yatp values (g dry wt bacteria/mole atp) of between 7.2 and 11.9 were calculated from molar growth yields and product formation. when oxidative phosphorylation in the electron tran ... | 1976 | 1086638 |
| taxonomical position of anaerobic diphtheroids from human oral cavity. | 1976 | 1076074 | |
| [effect of corynebacterium parvum on murine cultured bone marrow cells]. | the administration of corynebacterium parvum (c. parvum) stimulates in the mouse the bone marrow colony forming cell compartment in two stages. the first stage reaches pic values one day after two consecutive injections and the second, more important stage, reaches a pic at the 9th day which lasts over 27 days. there is no evidence that this effect is related to the liberation of csf. | 1976 | 816561 |
| effect of cytochalasin b on the adhesion of mouse peritoneal macrophages. | the adhesion of normal mouse macrophages to glass surfaces was reduced by nontoxic levels (1-50 mug/ml) of cytochalasin b in combination with a centrifugal force (1,000-8,000 g). macrophages nonspecifically activated by corynebacterium acnes were also detached by this treatment, but less effectively. the effects of cytochalasin b treatment on these cells were shown to be reversible. after detachment, the cells reattached to glass, appeared morphologically normal, and behaved like untreated cells ... | 1976 | 816801 |
| serum lysozyme as a marker of host resistance. i. production by macrophages resident in rat sarcomata. | with progressive growth of syngeneic sarcomata in rats there was a rise in serum levels of lysozyme which correlated with their immunogenicity and their macrophage content. by an examination of lymph/blood differences in normal and in tumour bearing rats and of the production of lysozyme by cells obtained from the tumours and maintained in vitro, it is apparent that the macrophages resident in a tumour mass make a massive contribution to the elevation in serum lysozyme concentrations. tumour cel ... | 1976 | 766806 |
| proceedings: the effect of bacille calmette-guérin (bcg) and corynebacterium parvum on the development of spontaneous mouse mammary carcinoma. | 1976 | 766891 | |
| immunology and lung cancer. | carcinoma of the lung is the number one cancer killer in the united states. the overall cure rate is about 10%, and although resection is the best treatment available, five-year survival following operation is only 25%. recent studies have shown that patients with lung cancer are immunosuppressed but that pulmonary tumors do contain tumor-associated antigens. studies of other human tumors indicate that immunotherapy can augment tumor immunity and can be an effective surgical adjuvant. this commu ... | 1976 | 769714 |
| immunogenicity of a rat leukaemia of spontaneous origin (sal). | the sal rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the res or by immunization with sal cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. however, immunization with sal cells exposed to low doses of mitomycin-c slowed the growth of the challenge inoculum. cells treated with high doses of mitomycin-c did not imm ... | 1976 | 769814 |
| nonspecific immunotherapy by corynebacterium parvum: phase i toxicity study in 12 patients with advanced cancer. | corynebacterium parvum, a non-specific immunopotentiator, was administered intravenously to 12 patients with advanced cancer at 2, 3, and 4 mg/m2 dose levels in combination with radiation therapy. one dose of c. parvum was given every 7 days for a total of 4 doses in 21 days. symptoms and signs developed by these patients for a period of 3 to 6 hours during and shortly after the i.v. infusion of the first dose of c. parvum were moderately severe in nine patients and mild in three patients. for t ... | 1976 | 769937 |
| studies on the enhancement by cyclophosphamide (nsc-26271) of artificial lung metastasis after labeled cell inoculation. | in a mouse model the retention of125i-5-iodo-2' -deoxyuridine-labeled tumor cells in the lung after iv injection was compared with the formation of tumor colonies in the lung 15 days after injection. the modification in lung retention after treatment with cyclophosphamide (cp), isophosphamide, corynebacterium parvum, and heparin paralleled the changes in lung-colony numbers by these treatments. since the modifications could be identified as early as 1 hour after iv administration of tumor cells, ... | 1976 | 1064469 |
| macrophage mediated tumor cell cytotoxicity. | the following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or c. parvum induced host resistance to solid tumors: (1) increased infiltration of tumors with histiocytes following systemic treatment with pyran;17 (2) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or c. parvum;17 (3) activated peritoneal macrophages mixed with tumor cell ... | 1976 | 1071961 |
| failure of corynebacterium parvum presensitization to modify the antitumor effects of systemic and local therapeutic injections of c. parvum in mice. | the therapeutic effects of iv and intralesional injection of corynebacterium parvum against mastocytoma p815 in mice, presentized and showing marked delayed hypersensitivity to c. parvum, were no different from those in unimmunized controls. | 1976 | 815560 |
| bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma. | combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ... | 1976 | 769970 |
| the role of macrophages in the adjuvant effect on antibody production of corynebacterium parvum. | spleen cells from mice pre-treated with c. parvum gave an enhanced in vitro antibody response to srbc, but not to dnp-pol. this enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. it is concluded that macrophages are directly involved in the adjuvant effect of c. parvum and the possible mechanisms of action are discussed. | 1976 | 770033 |
| "xenogeneic resistance" to rat bone marrow transplantation. iii. maturation age, and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation. | lethally irradiated c57 bl/6 mice and (c57 x a) f1 hybrids fail to accept doses of rat bone marrow cells (5 x 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. this phenomenon has been termed "xenogeneic resistance" (xr). xr in (c57 x a) f1 mice can be overridden by a very large inoculum of rat bone marrow (26 x 10(6) cells). xr is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. xr can be a ... | 1976 | 773442 |
| dynamics of mixed cultures of lactobacillus plantarum and propionibacterium shermanii. | the mixed culture of lactobacillus plantarum and propionibacterium shermanii grown anaerobically in glucose minimal medium exhibits features typical of a commensal interaction even though a number of complicating factors, such as a large maintenance requirement of l. plantarum and inhibition of growth of p. shermanii at low ph, are present. a simple mathematical model of the system is presented and is shown to reproduce rather well some of the features of the continuous mixed culture system in b ... | 1976 | 773448 |
| overview of tumor immunology in gynecologic oncology. | highlights of recent advances in the field of gynecologic tumor immunology are presented in an effort to demonstrate that at least some cancers of the female genitalia evoke an immune response that can be quantitated in the laboratory. the overview will discuss investigations into the various in vitro assays of both humoral and cell-mediated immunity. the concept of clinical testing of delayed hypersensitivity reactions as it relates to the clinical outcome of the patients with malignancy is pre ... | 1976 | 776391 |
| the effect of hydrocortisone on the immune response of mice treated with corynebacterium parvum. | 1976 | 776469 | |
| enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum. | the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ... | 1976 | 779492 |
| a modified plate holding system for anaerobic cultures. | a modified plate holding system for anaerobes has been developed which: 1) effectively reduces the volume of oxygen-free gas required, 2) promotes earlier bacterial growth, and 3) monitors the anaerobic atmosphere of the holding vessel and the rate of gas flow. cultures of bacteroides fragilis, clostridium perfringens, c. septicum, fusobacterium nucleatum, peptococcus sp. and propionibacterium sp. were evaluated for optimal growth. all cultures grew as well as or better when preincubated in the ... | 1976 | 782243 |
| augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance. | 1976 | 782731 | |
| immunotherapy of cancer in man. | 1976 | 786091 | |
| combined treatment of rodent fibrosarcoma by radiotherapy and immune adjuvant. | 1976 | 786964 | |
| the immunobiology of colorectal cancer. | 1976 | 793017 | |
| immunotherapy of cancer in man: current status and prospectus. | 1976 | 793477 | |
| design of phase-i trials of immunopotentiators for cancer therapy: levamisole and corynebacterium parvum. | 1976 | 793480 | |
| characteristics of bacteria isolated by the anaerobic roll-tube method from cheeses and ground beef. | in this study the methods of hungate were used to quantitate the anaerobic bacteria present in commercially available ground beef, cheddar cheese, and german hand cheese. of 235 anaerobic roll-tube isolates from ground beef and german hand cheese, all were facultative anaerobes. of 213 anaerobic roll-tube isolates from cheddar cheese, 91% were facultative anaerobes and 9% were obligate anaerobes. using results of biochemical tests, 14 or the 17 obligately anaerobic isolates from cheddar cheese w ... | 1976 | 793523 |
| relationship between intradermal tumor suppression and tumor immunity. | intradermal (id) injection of three tumor-immune stimulant mixtures (lstra-bcg, 13762a-bcg, cad2-corynebacterium parvum) was superior to the sc site for suppression of tumor growth: suppression of lstra-bcg mixtures was even less efficient after an ip or iv injectiouppression at all four sites. in the lstra-bcg model, the id site was not uniquely favorable for either the afferent or efferent limb of the immune response; the other sites produced equally effectiveimmunization or rejection of tumor ... | 1976 | 794505 |
| tetrapyrrole biosynthesis: n-methyl-n'-nitrosoguanidine-induced mutants of propionibacterium shermanii. | 1976 | 795726 | |
| immunotherapy of gastrointestinal cancer: the potential. | 1976 | 798647 | |
| immunocompetence, immunodeficiency and prognosis in cancer. | immunocompetence and prognosis are related in solid tumors, malignant lymphomas, and acute leukemia. among the parameters of immunocompetence vigorous delayed-type hypersensitivity responses to recall antigens or to primary immunization with keyhole limpet hemocyanin, vigorous in vitro lymphocyte blastogenic responses to mitogens such as pha, and relatively high b-lymphocyte levels, all correlate with a good prognosis. the spectrum of immune reactivity as measured by established delayed-type hyp ... | 1976 | 800324 |
| biological activities of propionibacterium acnes from the human oral cavity--dermal toxicity and res-stimulating activity. | 1976 | 802175 | |
| paradoxical effects of immunopotentiators on tumors and tumor viruses. | growth of tumors was inhibited or enhanced in mice by a synthetic (pyran) or a biologic (corynebacterium parvum) immunopotentiator. marked inhibition of leukemogenesis induced by friend leukemia virus was produced by prophylactic intraperitoneal treatment with pyran, while intravenous treatment with pyran (in the same dose and regimen) significantly enhanced growth of tumor virus. paradoxical effects were also seen with the biologic immunopotentiator c. parvum in solid tumor systems. treatment w ... | 1976 | 932503 |
| anaerobic bacteria from the large intestine of mice. | anaerobic bacteria from the colon of laboratory mice were enumerated and isolated using strict anaerobic techniques. direct microscopic counts revealed 4.4 x 10(10) organisms in each gram (wet weight) of colon contents. actual cultural counts averaged 3.2 x 10(10) organisms, which was 73% of the direct microscopic count. the tentatively identified genera were bacteroides, eubacterium, fusobacterium, lactobacillus, peptostreptococcus, and propionibacterium. strains of fusobacterium, lactobacillus ... | 1976 | 938042 |
| comparative study of two systems for detecting becteraemia and septicaemia. | two blood culturing systems were compared in parallel-a semi-automated radiometric method, bactec1, and the conventional method used in our laboratory. bactec contains radioactive 14c labelled substrates and monitors the level of 14co2 evolved by actively metabolizing bacteria. bactec was as efficient as the conventional method in detecting positive cultures and indicated that it was superior in detecting positive cultures earlier than the conventional system. | 1976 | 939807 |
| study of the mechanism of corynebacterium parvum anti-tumour activity. i. protective effect on the growth of two syngeneic tumours. | the protective effect of c. parvum against two different tumours - a lymphosarcoma and a mammary carcinoma - has been demonstrated. in the case of lymphosarcoma, a significant protective effect was obtained when both c. parvum and tumor cells were injected iv. in contrast in c3h mice the best protection was obtained when both c. parvum and mammary carcinoma cells were injected ip. thus both c. parvum and tumour cells must be inoculated by the same route which, however, varies for different tumou ... | 1976 | 946965 |
| observations following corynebacterium parvum administration to patients with advanced malignancy. a phase i study. | there has been increasing interest regarding the use of corynebacterium parvum (cp) with other modalities in the management of primary cancer. due to the paucity of specific information available relative to cp toxicity, a phase i study was carried out in patients with advanced disease. the purpose of the investigation was not to evaluate the effect of cp on tumor growth. from 273 injections of cp in 40 patients it was observed that following intravenous (i.v.) infusion of cp: a) a febrile respo ... | 1976 | 947509 |
| regression of a hamster melanoma with intralesional corynebacterium granulosum. | the present study was undertaken to compare the antitumour effects of intralesionally administered corynebacterium granulosum, corynebacterium parvum, bcg and saline on a hamster melanoma. forty-eight golden hamsters were inoculated subcutaneously with forthers melanotic melanoma no. 1. twenty-four animals bore palpable tumours which were excised. no non-excised group animal showed primary tumour regression. in the excised group, the tumours generally recurred at the excision site in the c. parv ... | 1976 | 949459 |
| treatment of rat fibrosarcoma by radiotherapy plus immune adjuvant. | combined radiotherapy and nonspecific adjuvant c. parvum or piromen treatment of rat tumors show improvement over radiotherapy alone. the most effective protocol, resulting in complete remission in 6 of 6 rats was obtained with c. parvum given i.p. in three doses 1 day prior to tumor x-irradiation of three doses of 1500 r each given on days 1, 4, and 8. animals receiving the same dose schedule without adjuvant had only partial regression of their tumor. without adjuvant, increasing the dose to 6 ... | 1976 | 949523 |
| radiation therapy and corynebacterium parvum in the treatment of murine tumors. | the relative effectiveness of local irradiation alone or combined with corynebacterium parvum (c parvum) treatment has been investigated employing four tumors: a mammary carcinoma (mca) (nonimmunogenic), a fibrosarcoma (moderately strongly immunogenic), and two squamous cell carcinomas (scc-2 being weakly and scc-4 being very weakly or nonimmunogenic). c parvum treatment was started when the isotransplanted tumor growing in the mouse leg was 5 mm in diameter and the local irradiation was adminis ... | 1976 | 949676 |
| differential quantitation of surface and subsurface bacteria of normal skin by the combined use of the cotton swab and the scrub methods. | by testing adjacent sites on the hypothenar eminence of the palm, enriched with bacteria by massaging the forehead, we found that the numbers of bacteria recovered from the skin surface by a wet cotton swab in 30 s were not significantly different from the numbers obtained by a brisk scrubbing with a blunted teflon policeman for 120 s. this was true of aerobes (gram-positive cocci) and anaerobes (propionibacteria). if the same site on the palm was swabbed two times for 15 s each time, 67 to 94% ... | 1976 | 950377 |
| vitamin b12 biosynthesis: in vitro formation of cobinamide from cobyric acid and l-threonine. | 1976 | 952513 | |
| proceedings: local corynebacterium parvum therapy in early breast cancer. | 1976 | 953485 | |
| proceedings: the effect of corynebacterium parvum on a subcutaneous tumour. | 1976 | 953487 | |
| intra-lesional injection of immunostimulants in bilateral rat tumors. | rats grafted with either two or six fragments of isogenic methylcholanthrene-induced transplantable fibrosarcomas were treated it1 with living bcg or killed c. parvum or a mixture of both immunostimulants. various tumor combination and therapeutic agent dosages were compared. when two fragments of the same tumor mcfifi2 (s) were grafted simultaneously, it treatment of one of these with 2 mg of bcg induced cure of both in 50% of the animals, but it injection of 2 x 10(9) c. parvum was completely ... | 1976 | 955748 |
| rapid separation of cobyrinic acid and its biosynthetic precursors by ion-exchange paper chromatography. | 1976 | 962120 | |
| inhibition of acetate and propionate formation upon aeration of resting cells of the anaerobic propionibacterium shermanii: evidence of the pasteur reaction. | when resting cell suspensions of the anaerobic p. shermanii were brought to an oxygen concentration of 0.64 mumoles/ml, acid formation was completely inhibited. the cells started to respire on the propionic acid previously accumulated furing anaerobiosis. glucose consumption was concomitantly decreased to about 60 percent of the rate during anaerobiosis. as the viability of the cells was not affected by the transition to aerobic conditions, the changes observed upon aeration were ascribed to the ... | 1976 | 969569 |
| identification of propionibacterium acnes and related organisms by precipitin tests with trichloroacetic acid extracts. | the serological identification of propionibacterium acnes, p. granulosum, and p. avidum, using trichloroacetic acid extracts, is described. with antisera prepared against reference strains, the method has been tested on 142 strains recently isolated from human skin. all except two of the strains could be identified serologically, and there was excellent agreement between the serological results and the fermentation pattern of the strains. two serological types of p. acnes and two of p. avidum we ... | 1976 | 972178 |
| immunological enhancement of leukemia l1210 by corynebacterium parvum in allogeneic mice. | the effect of corynebacterium parvum on the immune response of c57bl/6 mice (h-2b) to the allogeneic leukemia l1210 (h-2d) was investigated. mice were either left untreated or given c. parvum i.v. or i.p. in various dosages. seven days later they were challenged with 2.5 to 10 x 10(6) live l1210 cells i.p. control animals almost always rejected the challenge. in contrast, most mice pretreated with either 1.0, 0.5, or 0.25 mg of c. parvum i.v. and 1.0 or 0.5 mg i.p. exhibited enhanced growth of l ... | 1976 | 975053 |
| systemic treatment of breast cancer: past, present and future. | 1976 | 977407 | |
| mechanisms of antitumor action of corynebacterium parvum: the generation of cell-mediated tumor specific immunity. | 1976 | 978659 | |
| comparison of the potentiation of specific tumor immunity in mice by corynebacterium parvum or bcg. | two independent studies have compared killed c. parvum (cp) vaccine with viable bcg (pasteur) and bcg (glaxo) vaccines, respectively, for potentiation of antitumor immunity when injected with irradiated tumor cells into b6d2f1 and cba-t6t6 mice. both studies concurred that, for a given number of irradiated tumor cells, larger amounts (dry weight equivalent) of bcg than cp were required to produce similar degrees of tumor immunity. evidence also showed that stronger and more protracted immunity w ... | 1976 | 978769 |
| biotyping and serotyping of propionibacterium acnes strains isolated from different diagnostic materials. | fifty strains of propionibacterium acnes, five strains with the previous designation corynebacterium parvum and three strains of propionibacterium avidum were agglutinated by bacto-corynebacterium acnes 554 antiserum (difco); it was not possible to isolate any strain reacting only with 605 antiserum. only one strain of c. parvum reacted with both sera. 48 (88 per cent) out of 54 strains (p. acnes and c. parvum) belonged to voss' group i and 25 (47 per cent) belonged to pulverer's biotype a. str ... | 1976 | 983535 |
| antimicrobiol susceptibility of propinibacterium acnes and related microbial species. | the minimal inhibitory concentrations of 32 antimicrobial agents were established for 73 strains of propionibacterium acnes and four related species (p. granulosum, p. avidum, corynebacterium minutissimum, and c. parvum). most strains showed good susceptibility to those agents usually considered active against gram-positive organisms. with the exception of c. minutissimum, the strains tested revealed more or less identical susceptibility ranges. the lowest minimal inhibitory concentrations were ... | 1976 | 984781 |
| the characteristics of binding of corynebacterium parvum to glass-adherent mouse peritoneal exudate cells. | corynebacterium parvum, strain 10390, whole organisms were shown to bind to the surface of glass-adherent mouse peritoneal exudate cells in vitro. an hcl extract and a lipid extract of the organism were both capable of inhibiting this binding. the attachment of organisms was not affected by trypsin treatment of the cells, indicating that the plasma membrane receptor is not cell-bound antibody in nature. the binding was inhibited by various sugars, most of which are major components of the cell w ... | 1976 | 991461 |
| effects of corynebacterium parvum treatment and toxoplasma gondii infection on macrophage-mediated cytostasis of tumour target cells. | injection of mice with corynebacterium parvum or living or killed toxoplasma gondii was studied to determine the efficacy of these treatments in activating peritoneal macrophages to inhibit the uptake of [3h]tdr (cytostasis) by tumour target cells in vitro. in the presence of activated macrophages from mice treated i.p. with a wide dose range of either c. parvum or living toxoplasma, cytostasis was usually greater than 99%. this population of activated macrophages was transient in c. parvum-trea ... | 1976 | 992714 |
| experimental cancer immunotherapy: comparison of tumor rejection if f344 rats given live mycobacterium bovis (strain bcg) and killed corynebacterium parvum. | f344 rats received grafts of syngeneic 13762 mammary adenocarcinoma cells previously admixed with either living bcg of killed corynebacterium parvum administered sc or intradermally (id). animals given id transplants of tumor cells admixed with either bcg or killed c. parvum exhibited tumor growth for an average of 10 days, then regression in size and rejection of the tumor nodules. lesions were found in rats given sc transplants of tumor cells admixed with the killed microorganism for an averag ... | 1976 | 994209 |
| antitumor activity of killed corynebacterium parvum suspensions in a murine mammary adenocarcinoma cad2) system. | we studied the antitumor activity of killed corynebacterium parvum on the cad2 mammary adenocarcinoma in dba/2 mice. intratumor treatment had little or no effect on subcutaneous tumor growth. admixture of tumor cells with c. parvum before inoculation completely suppressed tumor growth. no tumor transplantation immunity was detected in mice inoculated with admixtures of c. parvum and tumor cells, but tumors were enhanced under certain circumstances. growth of a tumor inoculated sc or iv was consi ... | 1976 | 994219 |
| complement activation in vivo in cancer patients receiving c. parvum immunotherapy. | serum complement levels were assayed in 26 patients with disseminated cancer, who received immunotherapy with infusion of c. parvum. complement activation, indicated by the consumption of c3 or c4 or both, was found in 46% of the patients. serum samples showed direct correlation between decreased c3 and conversion of c3 proactivator, whereas such conversion did not occur when c4 alone was decreased. it is concluded that the bypass (properdin) pathway was activated in patients in whom c3 consumpt ... | 1976 | 999783 |
| decreased liver and lung drug-metabolizing activity in mice treated with corynebacterium parvum. | injections of killed suspensions of corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. in vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. it is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently ... | 1976 | 1000491 |
| in vitro behavior of corynebacterium parvum-activated cytotoxic macrophages. | 1976 | 1003401 | |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. iii. effect of c. parvum on cyclophosphamide metabolism. | results of investigations employing [14c]cyclophosphamide (cy) demonstrated that even though total plasma radioactivity was similar in female c3heb/fej mice treated either with cy alone or corynebacterium parvum and cy, the proportion of total activity due to nonmetabolized cy was greater when c. parvum was used. these findings indicated that the antitumor effect of c. parvum may not have been entirely due to its immunopotentiating properties but may also have been related to its effect on the m ... | 1976 | 1003505 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. | the cytotoxic macrophage was further characterized as an important effector cell in the inhibition of tumor growth. when we administered rifampin (a semisynthetic antibiotic that interferes with macrophage function but not viability) with corynebacterium parvum and/or cyclophosphamide to tumor-bearing c3heb/fej female mice, the tumor growth-inhibitory effects of the c. parvum were reduced. moreover, when bone marrow cells from those animals were cultured, we found a marked decrease in the cytoto ... | 1976 | 1003514 |
| effects of corynebacterium parvum alone and in combination with adriamycin in experimental tumor systems. | corynebacterium parvum (c. parvum) was used in antitumor tests against four murine tumor models in b6d2f1 mice. the c. parvum was effective at all doses and schedules tested against p388 leukemia, b16 melanoma, and lewis lung carcinoma but was ineffective against l1210 leukemia. combination immunochemotherapy of p388 leukemia and lewis lung carcinoma with c. parvum and adriamycin was better than either regimen alone in increasing the lifespan of mice with tumors. the results show that the effect ... | 1976 | 1009517 |
| the role of nonspecific immunotherapy in the treatment of breast cancer. | 1976 | 1013508 | |
| the immunostimulant corynibacterium parvum and hematopoietic toxicity of chemotherapy. | 1976 | 1019832 | |
| mouse strain differences in macrophage activation and anti-tumor activity induced by propionibacterium acnes (anaerobic coryneforms). | effect of propionibacterium acnes on macrophage activation and antitumor activity was examined in ddn and sl mice. (1) carbon clearance was enhanced to the same extent by p. acnes treatment in both strains. (2) number of peritoneal macrophages increased to the same extent by p. acnes treatment in both strains. (3) adhesiveness of peritoneal macrophages, as demonstrated by inhibition or migration or an increase in spreading cells, was enhanced more efficiently in ddn than in sl mice p. acnes tre ... | 1976 | 1021506 |
| [effect of porphyrins and their derivatives on biosynthesis of vitamin b 12 and the development of propionibacterium shermanii]. | the effect of uroporphyrin, coproporphyrin and their cobalt-containing derivatives on the biosynthesis of vitamin b12 and development of propionibacterium shermanii was studied. the compounds under study stimulated the vitamin synthesis by growing cultures and resting suspensions of these bacteria. cobalt porphyrins as the sole source of cobalt were used in the vitamin b12 biosynthesis. an addition of cobalt porphyrins to the growing culture of propionic bacteria increased in accumulation of the ... | 1976 | 1026936 |
| 1h and 31p fourier transform magnetic resonance studies of the conformation of enzyme-bound propionyl coenzyme a on the transcarboxylase. | the relaxation rates of the carbon-bound protons and of the three assigned phosphorus resonances of propionyl-coa were measured in solutions of free propionyl-coa and of the transcarboxylase-propionyl-coa complex. in free propionyl-coa, analysis of the 1/t1 values of 15 protons at 100 and 220 mhz and of 1/t1 and 1/t2 of the three phosphorus atoms at 40.5 mhz indicated free rotation of the propionyl region (taur approximately 3 x 10(-11) sec) but hindered motion of the remainder of the molecule w ... | 1976 | 1247514 |
| responsiveness of senescent mice to the antitumor properties of corynebacterium parvum. | the antitumor properties of corynebacterium parvum have been studied in young (3- to 8-month-old) and aged 18 or more months old) balb/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25- to 33-month-old) balb/c mice bearing primary mammary tumors. these aged balb/c mice were shown to be less immunoresponsive than their younger counterparts, and this, in combination with nonimmunological factors, made them more sen ... | 1976 | 1247995 |
| intermolecular tritium transfer in the transcarboxylase reaction. | transfer of tritium from [3-3h]pyruvate into propionyl-coa is found during the reaction of transcarboxylase: methylmalonyl-coa + pyruvate leads to oxalacetate + propionyl-coa. about 5% of the tritium counts that are labilized in the reaction are found in a position of the propionate that exchanges rapidly with water in the presence of transcarboxylase. transfer from [2-3h]propionate of propionyl-coa to pyruvate is real but only about one-tenth as great. the tritium transfers between reactants on ... | 1976 | 1249062 |
| suppression of the incidence of death with spontaneous tumours in dba/2 mice after corynebacterium parvum-mediated rejection of syngeneic tumours. | 1976 | 1250378 | |
| studies on the fc receptor bearing cells in a transplanted methylcholanthrene induced mouse fibrosarcoma. | the presence of fc receptors on the surface of cell suspensions obtained from a transplanted isogeneic methylcholanthrene induced murine fibrosarcoma has been investigated by determining the capacity of such cells to form rosettes with antibody coated srbc. these studies indicate that a large percentage of cells in the tumour had fc receptors on their surface. the proportion of such cells was increased by reducing the number of cells transplanted, by administering cyclophosphamide to the host, a ... | 1976 | 1252329 |
| proceedings: immunological mechanisms involved in the inhibition of tumour metastases by corynebacterium parvum. | 1976 | 1252731 | |
| [on uroporphyrinogen formation: studies with 1-aminomethyl-3, 8, 13, 18-tetra(2-carboxyethyl)-2, 7, 12, 17-tetracarboxymethylbilinogen (author's transl)]. | the preparation of the aminomethyl-bilinogen which results from formal "head to tail" condensation of porphobilinogen is described. the chemical cyclocondensation of this compound at ph 7.4 yields uroporphyrinogen i. enzymatic studies with enzyme preparations from propionibacterium shermanii, which synthesize uroporphyrinogens from porphobilinogen, show that the rate of cyclisation is increased by these enzymes and indicate that the bilinogen also might be used for uroporphyrinogen iii formation ... | 1976 | 1254244 |
| antitumor activity of corynebacterium parvum extracts. | extracts of corynebacterium parvum produced by mild hydrolysis of the whole organisms had antitumor activity if given iv 1 day before iv administration of fibrosarcoma cells or if given ip or sc in admixture with these cells. a lipid component seemed responsible for these effects. unlike whole bacteria, they had little immunotherapeutic activity if given 3 days after sc tumor implantation unless absorbed onto latex. however, organisms treated with acid did not have any immunotherapeutic effect i ... | 1976 | 1255777 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. ii. effect of cortisone acetate. | studies from this laboratory have demonstrated that the administration of cyclophosphamide (cy) and corynebacterium parvum (cp) over a prolonged time to c3h mice with established measurable tumors resulted in complete arrest of tumor growth as well as partial and complete regressions in many instances. a study of the effect of two different doses of cortisone acetate (ca), administered two or five times weekly, on the tumor inhibitory properties of this chemoimmunotherapeutic regimen indicated t ... | 1976 | 1255788 |
| anaerobic infections in children: a prospective study. | the prevalence and significance of anaerobic infections in patients at st. louis children's hospital were studied prospectively for a one-year period. blood, selected body fluids, and aspirates obtained from abscesses or areas of cellulitis were cultured using special anaerobic collection and processing techniques. infected peritoneal fluid from patients with gastrointestinal disease yielded a large proportion of all anaerobic isolates. the types of organisms isolated were common inhabitants of ... | 1976 | 1256941 |
| immunotherapy and human tumor immunology. | present knowledge about the immune response to tumors in man is briefly reviewed, and the effects of cancer on immune-system functions are noted. the concepts that human tumors elicit cell-mediated immune responses to tumor antigens are re-examined and modified; for example, cell-mediated immunity may be detectable only at certain stages of tumor growth. introduction of more sensitive methods for detecting antibodies is providing additional evidence for humoral immune responses to tumor-associat ... | 1976 | 1259292 |
| effect of corynebacterium parvum on the response to irradiation of a c3h fibrosarcoma. | a methylcholanthrene-induced fibrosarcoma of c3h mice has been used as 5th- to 6th-generation syngeneic transplant in an investigation of the role of corynebacterium parvum as an adjuvant to the therapeutic effect of local irradiation of established tumors. the most effective route for administration of c. parvum in this tumor system was i.v., and the greatest effect of the c. parvum-mediated tumor graft rejection was observed for tumor growing intracutaneously or s.c. an intermediate level of e ... | 1976 | 1260756 |
| cerebrospinal fluid shunt infections with anaerobic diphtheroids (propionibacterium species). | the clinical and laboratory findings in six cases of anaerobic diphtheroid infection of cerebrospinal fluid shunts are described. these organisms have been infrequently reported as a cause of shunt infections but our data indicate that such infections may be more common than currently appreciated. propionibacterium species are common contaminants of cerebrospinal fluid specimens, but when isolated from the spinal fluid of a patient with a shunt who has symptoms and signs compatible with infecti ... | 1976 | 1262917 |
| antitumour effect of corynebacterium parvum. possible mode of action. | 1976 | 1268035 | |
| bioassay for quantitating circulating tumor cells in a syngeneic mouse tumor system. | a bioassay is described for the quantitation of tumor cells in blood specimens in a syngeneic mouse tumor system (sarcoma 1 in a/j mice). the procedure involved i.m. injection of blood containing tumor cells into each thigh of normal recipient mice and, 14 days later, examination of the sites of injection for evidence of tumor growth. for each specimen, a tumor index was calculated based on the number of tumor takes and the size of the tumors. the number of tumor cells was determined by comparis ... | 1976 | 1268858 |
| corynebacterium parvum. | 1976 | 1269143 | |
| importance of actinomyces and certain gram-negative anaerobic organisms in the transformation of lymphocytes from patients with periodontal disease. | dental plaque deposits are known to be potent stimulants of lymphocyte transformation in patients with periodontal disease but not in normal subjects. since plaque deposits consist mainly of whole bacteria, the cell walls of the most commonly found organisms in plaque were tested for their capacity to induce lymphocyte transformation. there was a direct correlation between the severity of peridontal disease and the amount of transformation induced by the cell walls of oral bacteria and by solubi ... | 1976 | 1270144 |