Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females. | previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease. | 2013 | 24261910 |
| association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females. | previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease. | 2013 | 24261910 |
| priming the tooth surface with chlorhexidine and antibacterial activity of resin cement. | to evaluate the effect of priming the tooth surface with 2% chlorhexidine gluconate on antibacterial activity of resin cement. | 2013 | 24340277 |
| association between parity and dentition status among japanese women: japan public health center-based oral health study. | several studies have shown that parity is associated with oral health problems such as tooth loss and dental caries. in japan, however, no studies have examined the association. the purpose of this study was to determine whether parity is related to dentition status, including the number of teeth present, dental caries and filled teeth, and the posterior occlusion, in a japanese population by comparing women with men. | 2013 | 24144183 |
| dna methylation pattern of calca in preterm neonates with bacterial sepsis as a putative epigenetic biomarker. | diagnosis of bacterial sepsis in preterm neonates can be difficult when using serum markers that rely on physiological changes because these changes may not necessarily be the result of bacterial infections alone. this retrospective investigation explores the potential use of the dna methylation pattern of cpg sites in the promoter region of the calcitonin-related polypeptide α (calca) gene as an epigenetic biomarker for bacterial sepsis in preterm newborns. four novel changes in the dna methyla ... | 2013 | 24135723 |
| role of epigenetic reprogramming of host genes in bacterial pathogenesis. | the genomes are regularly targeted by epigenetic regulatory mechanisms (dna methylation, histone modifications, binding of regulatory proteins) in infected cells. in addition, proteins encoded by microbial genomes may disturb the action of a set of cellular promoters by interacting with the same epi-regulatory machinery. the outcome of this may result in epigenetic dysregulation and subsequent cellular dysfunctions that may manifest in or contribute to the development of pathological changes. ho ... | 2013 | 24235865 |
| dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. | analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. changes leading to specific biological states including some of the more complex diseases can now be characterized with relative ease. it is known that gut microbiota is involved in the pathogenesis of inflammatory bowel disease (ibd), mainly crohn's disease and ulcerative colitis, exhibiting symptoms in ... | 2013 | 24013298 |
| dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. | analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. changes leading to specific biological states including some of the more complex diseases can now be characterized with relative ease. it is known that gut microbiota is involved in the pathogenesis of inflammatory bowel disease (ibd), mainly crohn's disease and ulcerative colitis, exhibiting symptoms in ... | 2013 | 24013298 |
| fourth belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria. | to collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous belgian multicentre studies. | 2013 | 24008826 |
| fourth belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria. | to collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous belgian multicentre studies. | 2013 | 24008826 |
| dental profile of a community of recovering drug addicts: biomedical aspects. retrospective cohort study. | to obtain a biomedical oral profile of a community of adult drug addicts in treatment by analysing their dental health, with a view to determining whether the state of their oral health could be attributed primarily to their lifestyle and the direct consequences of drug abuse on their overall condition, rather than to the effects of the drugs used. | 2013 | 23722124 |
| from mice to women: the conundrum of immunity to infection during pregnancy. | resistance to infection is the ability of the host to evoke a strong immune response sufficient to eliminate the infectious agent. in contrast, maternal tolerance to the fetus necessitates careful regulation of immune responses. successful pregnancy requires the maternal host to effectively balance the opposing processes of maternal immune reactivity and tolerance to the fetus. however, this balance can be perturbed by infections which are recognized as the major cause of adverse pregnancy outco ... | 2013 | 23432873 |
| systemic anti-microbial agents used in periodontal therapy. | periodontitis is an infectious disease with marked inflammatory response, leading to destruction of underlying tissues. the aim of periodontal therapy is to eradicate the pathogens associated with the disease and attain periodontal health. this is achieved by non-surgical and surgical therapy; however, mechanical debridement and topical application of antiseptics may not be helpful in all cases. in such cases, adjunctive systemic antibiotic therapy remains the treatment of choice. it can reach m ... | 2013 | 23869120 |
| evaluation of the effect of probiotic (inersan®) alone, combination of probiotic with doxycycline and doxycycline alone on aggressive periodontitis - a clinical and microbiological study. | the purpose of the present study was to evaluate the effect of a probiotic (inersan®) alone, a combination of the probiotic with doxycycline and doxycycline alone on aggressive periodontitis patients. | 2013 | 23634432 |
| epigenetic regulation of tnfa expression in periodontal disease. | tumor necrosis factor-α (tnf-α) plays a central role in the molecular pathogenesis of periodontal disease. however, the epigenetic regulation attributable to microbial and inflammatory signals at the biofilm-gingival interface are poorly understood. in this study, the dna methylation alteration within the tnfa promoter in human gingival biopsies from different stages of periodontal disease is investigated and the regulatory mechanism of tnfa transcription by dna methylation is explored. | 2013 | 23368949 |
| local drug delivery agents as adjuncts to endodontic and periodontal therapy. | in the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained/controlled drug release, high antimicrobial activity and low systemic side effects. the conventional method for the elimination of subgingival microbial infection includes mechanical debridement, irrigation with antimicrobial agents or surgical access. but, the effectiveness of con ... | 2013 | 24868252 |
| changes in clinical and microbiological periodontal profiles relate to progression of carotid intima-media thickness: the oral infections and vascular disease epidemiology study. | no prospective studies exist on the relationship between change in periodontal clinical and microbiological status and progression of carotid atherosclerosis. | 2013 | 24166489 |
| crevicular fluid biomarkers and periodontal disease progression. | assess the ability of a panel of gingival crevicular fluid (gcf) biomarkers as predictors of periodontal disease progression (pdp). | 2013 | 24303954 |
| crevicular fluid biomarkers and periodontal disease progression. | assess the ability of a panel of gingival crevicular fluid (gcf) biomarkers as predictors of periodontal disease progression (pdp). | 2013 | 24303954 |
| interleukin-8 responses of multi-layer gingival epithelia to subgingival biofilms: role of the "red complex" species. | periodontitis is an infectious inflammatory disease that results in the destruction of the tooth-supporting (periodontal) tissues. the gram-negative anaerobic species porphyromonas gingivalis, tannerella forsythia and treponema denticola, (also known as the "red complex" species) are highly associated with subgingival biofilms at periodontitis-affected sites. a major chemokine produced by the gingival epithelium in response to biofilm challenge, is interleukin (il)-8. the aim of this in vitro st ... | 2013 | 24339946 |
| impact of early colonizers on in vitro subgingival biofilm formation. | the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ... | 2013 | 24340084 |
| periodontitis and buerger's disease: recent advances. | buerger's disease (bd) is a relatively rare thrombotic, occlusive and non-atherosclerotic clinical syndrome of unknown etiology. in recent years, numerous epidemiological studies confirmed the strong association between chronic anaerobic periodontal infection and development of cardiovascular diseases, including bd. therefore, the aim of this study is to clarify association between periodontal pathogens and buerger's disease. confirmation of presence and identification of periopathogens in patie ... | 2013 | 24554799 |
| haplotype analysis of interleukin-8 gene polymorphisms in chronic and aggressive periodontitis. | periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction. interleukin-8 (il8) is important in the regulation of the immune response. the aim of this study was to analyze four polymorphisms in the il8 gene in relation to chronic (cp) and aggressive (agp) periodontitis. | 2013 | 24368875 |
| bacteremia following scaling and root planing: a clinico-microbiological study. | bacteremia frequently occurs after treatment procedures such as extractions, scaling, root planing, periodontal surgery. there is currently significant interest in the possibility that bacteremia with oral bacteria may play role in pathogenesis of atherosclerosis. there are well-conducted studies that have determined the frequency of passage of periodontal microorganisms to the bloodstream after periodontal treatment. there is scarce information related to the incidence of periodontopathic micro ... | 2013 | 24554880 |
| salivary biomarkers: toward future clinical and diagnostic utilities. | the pursuit of timely, cost-effective, accurate, and noninvasive diagnostic methodologies is an endeavor of urgency among clinicians and scientists alike. detecting pathologies at their earliest stages can significantly affect patient discomfort, prognosis, therapeutic intervention, survival rates, and recurrence. diagnosis and monitoring often require painful invasive procedures such as biopsies and repeated blood draws, adding undue stress to an already unpleasant experience. the discovery of ... | 2013 | 24092855 |
| effect of controlled-release periochip™ on clinical and microbiological parameters in patients of chronic periodontitis. | the aim of the present study was to evaluate and compare the clinical and microbiological effectiveness of periochip™ as an adjunct to scaling and root planing (srp) with srp alone in patients with chronic periodontitis. | 2013 | 24174754 |
| a consortium of aggregatibacter actinomycetemcomitans, streptococcus parasanguinis, and filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis. | aggregatibacter actinomycetemcomitans-induced localized aggressive periodontitis (lap) in african-american adolescents has been documented but is poorly understood. two thousand fifty-eight adolescents aged 11 to 17 years were screened for their periodontal status and the presence of a. actinomycetemcomitans in their oral cavity. seventy-one a. actinomycetemcomitans-negative and 63 a. actinomycetemcomitans-positive periodontally healthy subjects were enrolled, sampled, examined, and radiographed ... | 2013 | 23784124 |
| the correlation between chronic periodontitis and oral cancer. | infections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. the discussion about human papilloma virus (hpv) in oral squamous cell carcinoma (oscc) points at a general role of infection for the development of oral carcinomas. furthermore, first studies describe a correlation between chronic periodontitis and oscc, thus, characterizing chronic inflammation as being a possible trigger for oscc. in front of this background, we pre ... | 2013 | 23936684 |
| salivary ph: a diagnostic biomarker. | saliva contains a variety of host defense factors. it influences calculus formation and periodontal disease. different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. with a multitude of biomarkers and complexities in their determination, the salivary ph may be tried to be used as a quick chairside test. the aim of this study was to analyze the ph of saliva and determine its relevance to the severity of periodontal disease. | 2013 | 24174725 |
| predictive, preventive, personalised and participatory periodontology: 'the 5ps age' has already started. | an impressive progress in dentistry has been recorded in the last decades. in order to reconsider guidelines in dentistry, it is required to introduce new concepts of personalised patient treatments: the wave of predictive, preventive and personalised medicine is rapidly incoming in dentistry. worldwide dentists have to make a big cultural effort in changing the actual 'reactive' therapeutic point of view, belonging to the last century, into a futuristic 'predictive' one. the first cause of toot ... | 2013 | 23763842 |
| periodontal disease: a covert source of inflammation in chronic kidney disease patients. | the prevalence of atherosclerotic complications (myocardial infarction, stroke, and sudden death) is increased in end-stage renal disease (esrd) patients, especially in haemodialysis patients. increasing evidence suggests that both in general population and in dialysis patients, systemic inflammation plays a dominant role in the pathogenesis of atherosclerotic complications. in general population, also, evidence shows that moderate to severe periodontitis can contribute to inflammatory burden by ... | 2013 | 23840952 |
| lessons learned and unlearned in periodontal microbiology. | periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or below the gingival margin and progress largely as a result of the inflammation elicited by specific subgingival species. in the past few decades, efforts to understand the periodontal microbiota have led to an exponential increase in information about biofilms associated with periodontal health and disease. in fact, the oral microbiota is one of the best-characterized microbiomes that colonize the huma ... | 2013 | 23574465 |
| mobile microbiome: oral bacteria in extra-oral infections and inflammation. | the link between oral infections and adverse systemic conditions has attracted much attention in the research community. several mechanisms have been proposed, including spread of the oral infection due to transient bacteremia resulting in bacterial colonization in extra-oral sites, systemic injury by free toxins of oral pathogens, and systemic inflammation caused by soluble antigens of oral pathogens. mounting evidence supports a major role of the systemic spread of oral commensals and pathogen ... | 2013 | 23625375 |
| periodontitis in pregnant baboons: systemic inflammation and adaptive immune responses and pregnancy outcomes in a baboon model. | chronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. | 2013 | 23710643 |
| periodontitis in pregnant baboons: systemic inflammation and adaptive immune responses and pregnancy outcomes in a baboon model. | chronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. | 2013 | 23710643 |
| effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. i. overall effect and kinetics of change. | to examine the 2-year post-therapy kinetics of change in the composition of subgingival biofilms. | 2013 | 23710672 |
| the surface layer of tannerella forsythia contributes to serum resistance and oral bacterial coaggregation. | tannerella forsythia is an anaerobic, gram-negative bacterium involved in the so-called "red complex," which is associated with severe and chronic periodontitis. the surface layer (s-layer) of t. forsythia is composed of cell surface glycoproteins, such as tfsa and tfsb, and is known to play a role in adhesion/invasion and suppression of proinflammatory cytokine expression. here we investigated the association of this s-layer with serum resistance and coaggregation with other oral bacteria. the ... | 2013 | 23357386 |
| functional differences of porphyromonas gingivalis fimbriae in determining periodontal disease pathogenesis: a literature review. | porphyromonas gingivalis is implicated in chronic and aggressive periodontitis. this bacterium has numerous virulence factors and one is the fimbriae, which is quite important for bacterial colonization. fimbriae are appendices that anchor to the bacterial wall and are comprised of the protein fimbriline encoded by the fima gene. thus far, six genotypes have been identified, fima i to v and ib. genotypes ii and iv are associated with periodontal disease, while genotype i is related to gingival h ... | 2013 | 24892323 |
| mixed red-complex bacterial infection in periodontitis. | the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia (formerly bacteroides forsythus), are recognized as the most important pathogens in adult periodontal disease. these bacteria are usually found together in periodontal pockets, suggesting that they may cause destruction of the periodontal tissue in a cooperative manner. this article discusses the interspecies pathogenic interactions within the red complex. | 2013 | 23533413 |
| role of the nk cell-activating receptor cracc in periodontitis. | periodontitis is a highly prevalent, biofilm-mediated chronic inflammatory disease that results in the loss of the tooth-supporting tissues. it features two major clinical entities: chronic periodontitis, which is more common, and aggressive periodontitis, which usually has an early onset and a rapid progression. natural killer (nk) cells are a distinct subgroup of lymphocytes that play a major role in the ability of the innate immune system to steer immune responses. nk cells are abundant in pe ... | 2013 | 23250953 |
| clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes. | regulators of peri-implant bone loss in patients with diabetes appear to involve multiple risk factors that have not been clearly elucidated. this study was conducted to explore putative local etiologic factors on implant bone loss in relation to type 2 diabetes mellitus, including clinical, microbial, salivary biomarker, and psychosocial factors. | 2013 | 23445216 |
| clinical, microbiological, and salivary biomarker profiles of dental implant patients with type 2 diabetes. | regulators of peri-implant bone loss in patients with diabetes appear to involve multiple risk factors that have not been clearly elucidated. this study was conducted to explore putative local etiologic factors on implant bone loss in relation to type 2 diabetes mellitus, including clinical, microbial, salivary biomarker, and psychosocial factors. | 2013 | 23445216 |
| periodontal disease and diabetes mellitus. | periodontal disease (pd) is one of the most commonly known human chronic disorders. the relationship between pd and several systemic diseases such as diabetes mellitus (dm) has been increasingly recognized over the past decades. | 2013 | 23559105 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| serum igg antibody levels to periodontal microbiota are associated with incident alzheimer disease. | periodontitis and alzheimer disease (ad) are associated with systemic inflammation. this research studied serum igg to periodontal microbiota as possible predictors of incident ad. | 2014 | 25522313 |
| s-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis. | mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. | 2014 | 25478918 |
| shifts in campylobacter species abundance may reflect general microbial community shifts in periodontitis progression. | oral campylobacter species have been found to be associated with periodontitis progression. while the etiological significance of campylobacter rectus is quite established, the association of c. gracilis, c. concisus, and c. curvus with health or disease remains contradictory. | 2014 | 25412608 |
| the oral microbiome and the immunobiology of periodontal disease and caries. | the composition of the oral microbiome differs from one intraoral site to another, reflecting in part the host response and immune capacity at each site. by focusing on two major oral infections, periodontal disease and caries, new principles of disease emerge. periodontal disease affects the soft tissues and bone that support the teeth. caries is a unique infection of the dental hard tissues. the initiation of both diseases is marked by an increase in the complexity of the microbiome. in period ... | 2014 | 25447398 |
| association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. | in this study, the gingival conditions and the quantitative detection for aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, porphyromonas gingivalis and prevotella intermedia in pregnant women were determined. | 2014 | 25591021 |
| relationship of clinical and microbiological variables in patients with type 1 diabetes mellitus and periodontitis. | the aim of the study was to analyze how metabolic control of type 1 diabetes is related to clinical and microbiological periodontal parameters. | 2014 | 25294115 |
| role of porphyromonas gingivalis gingipains in multi-species biofilm formation. | periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic inflammatory reactions by the affected tissue. the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola are commonly found as part of the microbiota of subgingival biofilms, and they are associated with the occurren ... | 2014 | 25270662 |
| expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. | periodontitis is an inflammatory infectious disease that destroys the tooth-supporting tissues. it is caused by multi-species subgingival biofilms that colonize the tooth surface. porphyromonas gingivalis, treponema denticola and tannerella forsythia (i.e. 'red complex' bacteria) are characteristic subgingival biofilm species. the triggering receptor expressed on myeloid cells 1 (trem-1) is a cell surface receptor of the immunoglobulin superfamily, with a role in the amplification of proinflamma ... | 2014 | 24924298 |
| newly identified pathogens associated with periodontitis: a systematic review. | there is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. however, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. the aim of this systematic re ... | 2014 | 25074492 |
| bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators. | periodontitis is an infectious and inflammatory disease of polymicrobial etiology that can lead to the destruction of bones and tissues that support the teeth. the management of chronic periodontitis (cp) relies heavily on elimination or at least control of known pathogenic consortia associated with the disease. until now, microbial plaque obtained from the subgingival (subg) sites has been the primary focus for bacterial community analysis using deep sequencing. in addition to the use of subg p ... | 2014 | 25225610 |
| infectious burden and atherosclerosis: a clinical issue. | atherosclerotic cardiovascular diseases, chronic inflammatory diseases of multifactorial etiology, are the leading cause of death worldwide. in the last decade, more infectious agents, labeled as "infectious burden", rather than any single pathogen, have been showed to contribute to the development of atherosclerosis through different mechanisms. some microorganisms, such as chlamydia pneumoniae (c. pneumoniae), human cytomegalovirus, etc. may act directly on the arterial wall contributing to en ... | 2014 | 25032197 |
| oral fluid based biomarkers in periodontal disease: part 1. saliva. | traditional clinical measurements such as probing pocket depth, bleeding on probing, clinical attachment loss; plaque index and radiographs used for periodontal diagnosis are often of limited usefulness as they are indicators of previous periodontal disease rather than present disease activity. a literature search was carried out to find out all the available tests that indicate periodontal disease markers in saliva. all major databases were searched to compile the information on published repor ... | 2014 | 25214743 |
| serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis. | the role of serum monocyte chemoattractant protein-1 (mcp-1) as a biomarker of periodontitis is well documented; however, its role in diabetic patients with periodontitis is unknown. | 2014 | 25143907 |
| treatment alternatives to negotiate peri-implantitis. | peri-implant diseases are becoming a major health issue in dentistry. despite the magnitude of this problem and the potential grave consequences, commonly acceptable treatment protocols are missing. hence, the present paper reviews the literature treatment of peri-implantitis in order to explore their benefits and limitations. treatment of peri-implantitis may include surgical and nonsurgical approaches, either individually or combined. nonsurgical therapy is aimed at removing local irritants fr ... | 2014 | 26556414 |
| massive parallel sequencing provides new perspectives on bacterial brain abscesses. | rapid development within the field of massive parallel sequencing (mps) is about to bring this technology within reach for diagnostic microbiology laboratories. we wanted to explore its potential for improving diagnosis and understanding of polymicrobial infections, using bacterial brain abscesses as an example. we conducted a prospective nationwide study on bacterial brain abscesses. fifty-two surgical samples were included over a 2-year period. the samples were categorized as either spontaneou ... | 2014 | 24671797 |
| microbial community profiling of human saliva using shotgun metagenomic sequencing. | human saliva is clinically informative of both oral and general health. since next generation shotgun sequencing (ngs) is now widely used to identify and quantify bacteria, we investigated the bacterial flora of saliva microbiomes of two healthy volunteers and five datasets from the human microbiome project, along with a control dataset containing short ngs reads from bacterial species representative of the bacterial flora of human saliva. genius, a system designed to identify and quantify bacte ... | 2014 | 24846174 |
| bacteria and bacterial dna in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. | several studies have reported an association between chronic periodontitis (cp) and cardiovascular diseases. detection of periodontopathogens, including red complex bacteria (rcb), in vascular lesions has suggested these bacteria to be involved in the pathogenesis of atherosclerosis and abdominal aortic aneurysms. | 2014 | 25006361 |
| prevalence of clinical periodontitis and putative periodontal pathogens among south indian pregnant women. | in view of recent understanding of the association of periodontal infections and adverse pregnancy outcomes, the present investigation was undertaken to study the periodontal infections among 390 asymptomatic pregnant women and to find an association of bacterial etiologies with the disease. prevalence of gingivitis was 38% and clinical periodontitis was 10% among the study population. subgingival plaque specimens were subjected to multiplex pcr targeting ten putative periodontopathogenic bacter ... | 2014 | 24899898 |
| subgingival bacteria in ghanaian adolescents with or without progression of attachment loss. | this study describes subgingival bacterial profiles associated with clinical periodontal status in ghanaian adolescents with or without progression of attachment loss. | 2014 | 24834145 |
| life in a diverse oral community - strategies for oxidative stress survival. | while the oral cavity harbors more than 680 bacterial species, the interaction and association of selected bacterial species play a role in periodontal diseases. bacterial species including porphyromonas gingivalis, treponema denticola and tannerella forsythia, a consortium previously designated as the "red complex" is now being expanded to include other new emerging pathogens that are significantly associated with periodontal disease. | 2014 | 26744578 |
| cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience. | periodontics has evolved from a simplistic model to a more complex interplay between infection and host response. genetic factors have been a new addition to the list of risk factors for periodontal diseases. the processes leading to destruction and regeneration of the destroyed tissues are of great interest to both researchers and clinicians. the selective susceptibility of subjects for periodontitis has remained an enigma and wide varieties of risk factors have been implicated for the manifest ... | 2014 | 24843315 |
| gingival tissue transcriptomes identify distinct periodontitis phenotypes. | the currently recognized principal forms of periodontitis-chronic and aggressive-lack an unequivocal, pathobiology-based foundation. we explored whether gingival tissue transcriptomes can serve as the basis for an alternative classification of periodontitis. we used cross-sectional whole-genome gene expression data from 241 gingival tissue biopsies obtained from sites with periodontal pathology in 120 systemically healthy nonsmokers with periodontitis, with available data on clinical periodontal ... | 2014 | 24646639 |
| identification of microbial pathogens in periodontal disease and diabetic patients of south indian population. | periodontitis have been referred to as the sixth complication of diabetes found in high prevalence among diabetic patients than among healthy controls. the aim of the present study was to examine the periodontal disease status among collected dental plaque samples. chromosomal dna was isolated and amplified by universal primers. the dna was sequenced for bacterial confirmation and phylogenetic analysis performed for the evolutionary relationship with other known pathogens. no amplification produ ... | 2014 | 24966528 |
| bacteriological analysis of necrotic pulp and fistulae in primary teeth. | primary teeth work as guides for the eruption of permanent dentition, contribute for the development of the jaws, chewing process, preparing food for digestion, and nutrient assimilation. treatment of pulp necrosis in primary teeth is complex due to anatomical and physiological characteristics and high number of bacterial species present in endodontic infections. the bacterial presence alone or in association in necrotic pulp and fistula samples from primary teeth of boys and girls was evaluated ... | 2014 | 24676582 |
| pathogens and host immunity in the ancient human oral cavity. | calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. we report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. we characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ... | 2014 | 24562188 |
| subgingival periodontal pathogens associated with chronic periodontitis in yemenis. | subgingival microbial profile associated with periodontitis has been reported to significantly differ by geographical location. the purpose of this study was to assess the association between a panel of putative periodontal bacterial pathogens and chronic periodontitis among yemenis. | 2014 | 24548674 |
| in vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts. | findings from animal and human studies have indicated that an oily calcium hydroxide suspension (ochs) may improve early wound healing in the treatment of periodontitis. calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of ochs on the influence of periodontal wound healing/regeneration is still very limited. the purpose of this in vitro study was to investigate the effect of ochs on periodontopathogenic bacteria as well as on the ... | 2014 | 24475753 |
| periodontal disease bacteria specific to tonsil in iga nephropathy patients predicts the remission by the treatment. | immunoglobulin (ig)a nephropathy (igan) is the most common form of primary glomerulonephritis in the world. some bacteria were reported to be the candidate of the antigen or the pathogenesis of igan, but systematic analysis of bacterial flora in tonsil with igan has not been reported. moreover, these bacteria specific to igan might be candidate for the indicator which can predict the remission of igan treated by the combination of tonsillectomy and steroid pulse. | 2014 | 24489644 |
| association between hypertension and periodontitis: possible mechanisms. | this review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. hypertension is one of the major risk factors for cardiovascular diseases. oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. inflammation has received much attention recently and may contribute to a pivotal role in ... | 2014 | 24526921 |
| microbial role in periodontitis: have we reached the top? some unsung bacteria other than red complex. | the microbial etiology of periodontal disease has been the focus of researchers for a long time. the search for the pathogens of periodontal diseases has been underway for more than 100 years, and continues up today. despite the increasing knowledge about oral microbiota, we are not able to implicate any one particular organism that can be considered as a candidate pathogen. in fact the term "candidate pathogen" has lost its steam with a myriad of microorganisms being incriminated from time to t ... | 2014 | 24744537 |
| genomic evidence for the emergence and evolution of pathogenicity and niche preferences in the genus campylobacter. | the genus campylobacter includes some of the most relevant pathogens for human and animal health; the continuous effort in their characterization has also revealed new species putatively involved in different kind of infections. nowadays, the available genomic data for the genus comprise a wide variety of species with different pathogenic potential and niche preferences. in this work, we contribute to enlarge this available information presenting the first genome for the species campylobacter sp ... | 2014 | 25193310 |
| evolution and comparative genomics of campylobacter jejuni st-677 clonal complex. | campylobacter is the most common bacterial cause of gastroenteritis in the european union with over 200,000 laboratory-confirmed cases reported annually. this is the first study to describe findings related to comparative genomics analyses of the sequence type (st)-677 clonal complex (cc), a campylobacter jejuni lineage associated with bacteremia cases in humans. we performed whole-genome sequencing, using illumina hiseq sequencing technology, on five related st-677 cc isolates from two chicken ... | 2014 | 25193305 |
| biological roles of the o-methyl phosphoramidate capsule modification in campylobacter jejuni. | campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, and the capsular polysaccharide (cps) of this organism is required for persistence and disease. c. jejuni produces over 47 different capsular structures, including a unique o-methyl phosphoramidate (meopn) modification present on most c. jejuni isolates. although the meopn structure is rare in nature it has structural similarity to some synthetic pesticides. in this study, we have demonstrated, by whole genome comparis ... | 2014 | 24498018 |
| identification and characterization of an invasion antigen b gene from the oral pathogen campylobacter rectus. | the oral bacterium, campylobacter rectus, is an etiological agent of periodontitis. the virulence genes of c. rectus are largely unknown. the aim of this study was to query c. rectus for the presence of an invasion antigen b (ciab) gene, which is needed for cell invasion by the related species campylobacter jejuni. pcr and pcr-walking identified a ciab from c. rectus. in silico analyses of c. rectus 314 ciab (cr-ciab) revealed an orf of 1,830 base pairs. the cr-ciab protein shared significant se ... | 2014 | 24426164 |
| identification and characterization of an invasion antigen b gene from the oral pathogen campylobacter rectus. | the oral bacterium, campylobacter rectus, is an etiological agent of periodontitis. the virulence genes of c. rectus are largely unknown. the aim of this study was to query c. rectus for the presence of an invasion antigen b (ciab) gene, which is needed for cell invasion by the related species campylobacter jejuni. pcr and pcr-walking identified a ciab from c. rectus. in silico analyses of c. rectus 314 ciab (cr-ciab) revealed an orf of 1,830 base pairs. the cr-ciab protein shared significant se ... | 2014 | 24426164 |
| host response, malnutrition and oral diseases. part 1. | effective defense response of the body requires the proper nutritional and metabolic preparation and adequate energy expenditure. every pathological process with coexisting malnutrition is subject to an increased risk of failure and complications in medical treatment, which is a serious threat to human health and life. malnutrition, particularly protein-calorie malnutrition, is characterized by a decrease in resistance, particularly involving cellular immune deficiency, which in turn causes a si ... | 2014 | 26155172 |
| effect of intensive oral hygiene regimen during pregnancy on periodontal health, cytokine levels, and pregnancy outcomes: a pilot study. | data are limited on the potential effect of intensive oral hygiene regimens and periodontal therapy during pregnancy on periodontal health, gingival crevicular fluid (gcf) and serum cytokines, and pregnancy outcomes. | 2014 | 25079400 |
| general immune status and oral microbiology in patients with different forms of periodontitis and healthy control subjects. | immunological processes in the etiopathogenesis of periodontitis, especially the aggressive form, are not well understood. this study examined clinical as well as systemic immunological and local microbiological features in healthy controls and patients with different forms of periodontitis. | 2014 | 25299619 |
| performance of two resin-containing blood culture media in detection of bloodstream infections and in direct matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) broth assays for isolate identification: clinical comparison of the bact/alert plus and bactec plus systems. | we compared the clinical performances of the bact/alert plus (biomérieux) and bactec plus (becton dickinson) aerobic and anaerobic blood culture (bc) media with adsorbent polymeric beads. patients ≥ 16 years old with suspected bloodstream infections (bsis) were enrolled in intensive care units and infectious disease wards. a single 40-ml blood sample was collected from each and used to inoculate (10 ml/bottle) one set of bact/alert plus cultures and one set of bactec plus cultures, each set cons ... | 2014 | 25031441 |
| antibacterial activity of as-annealed tio2 nanotubes doped with ag nanoparticles against periodontal pathogens. | it is important to develop functional transmucosal implant surfaces that reduce the number of initially adhering bacteria and they need to be modified to improve the anti-bacterial performance. commercially pure ti sheets were anodized in an electrolyte containing ethylene glycol, distilled water and ammonium fluoride at room temperature to produce tio2 nanotubes. these structures were then annealed at 450°c to transform them to anatase. as-annealed tio2 nanotubes were then treated in an electro ... | 2014 | 25202230 |
| porphyromonas gingivalis groel induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. | porphyromonas gingivalis is a major periodontal pathogen that contains a variety of virulence factors. the antibody titer to p. gingivalis groel, a homologue of hsp60, is significantly higher in periodontitis patients than in healthy control subjects, suggesting that p. gingivalis groel is a potential stimulator of periodontal disease. however, the specific role of groel in periodontal disease remains unclear. here, we investigated the effect of p. gingivalis groel on human periodontal ligament ... | 2014 | 25058444 |
| effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults. | oral bacteria live in symbiosis with the host. therefore, when mouthwashes are indicated, selective inhibition of taxa contributing to disease is preferred instead of broad-spectrum antimicrobials. the potential selectivity of an oxygenating mouthwash, ardox-x® (ax), has not been assessed. the aim of this study was to determine the antimicrobial potential of ax and the effects of a twice-daily oral rinse on dental plaque composition. | 2014 | 25101249 |
| association of periodontal disease and pre-term low birth weight infants. | the incidence of pre-term low birth weight still prevails in developed as well as developing countries though the numbers may vary. periodontitis is a chronic inflammatory process with multifactorial etiology and adversely affects the outcome of pregnancy which becomes a major public health problem. the association of periodontitis as risk factor for pre-term birth has been in extensive research in the past two decades when a number of studies investigated this relationship. however, definite co ... | 2014 | 26085737 |
| association of periodontal disease and pre-term low birth weight infants. | the incidence of pre-term low birth weight still prevails in developed as well as developing countries though the numbers may vary. periodontitis is a chronic inflammatory process with multifactorial etiology and adversely affects the outcome of pregnancy which becomes a major public health problem. the association of periodontitis as risk factor for pre-term birth has been in extensive research in the past two decades when a number of studies investigated this relationship. however, definite co ... | 2014 | 26085737 |
| septic cavernous sinus thrombosis due to campylobacter rectus infection. | we report a case of cavernous sinus thrombosis in a 55-year-old chinese man who presented with headache, ophthalmoplegia and ptosis. campylobacter rectus was eventually isolated from the blood cultures. he was treated with broad-spectrum antibiotics, anticoagulation and steroids with improvement in his condition. to our knowledge, this is the first documented case of septic cavernous sinus thrombosis caused by c. rectus. | 2014 | 24842357 |
| the microbiome, parturition, and timing of birth: more questions than answers. | the causes of preterm birth are multifactorial, but its association with infection has been well-established. the predominant paradigm describes an ascending infection from the lower genital tract through the cervix and into the presumably sterile fetal membranes and placenta. thus, an evaluation of the role of the vaginal microbiome in preterm birth is implicated. however, emerging fields of data described in this review suggest that the placenta might not be sterile, even in the absence of cli ... | 2014 | 24793619 |
| exome capture from saliva produces high quality genomic and metagenomic data. | targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. targeted capture also has the potential to facilitate the generation of genomic data from dna collected via saliva or buccal cells. dna samples derived from these cell types tend to have a lower human dna yield, may be degraded from age and/or have contamination from bacteria or other ambient oral microbiota. however ... | 2014 | 24708091 |
| role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? | our understanding of the microbial involvement in inflammatory bowel disease (ibd) pathogenesis has increased exponentially over the past decade. the development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for crohn's disease in particular has led to better understanding of the aetiopathogenesis of ibd. the microbial studies have elaborated ... | 2014 | 24574795 |
| identification and characterization of a putative chemotaxis protein, chey, from the oral pathogen campylobacter rectus. | campylobacter rectus is an understudied oral bacterium that contributes to periodontitis. processes that contribute to the disease-causing capabilities of pathogens, such as chemotaxis, are largely unknown in c. rectus. the aim of this study was to better understand c. rectus chemotaxis, by examining the c. rectus genome for the presence of a chey gene. chey proteins play a part in chemotaxis by acting as two-component response regulators. significantly, chey proteins from several pathogens, inc ... | 2014 | 25598863 |
| biofilm community diversity after exposure to 0·4% stannous fluoride gels. | to test the effect of 0·4% stannous fluoride (snf2 ) glycerine-based gels on specific portions of the bacterial community in both a clinical observational study and in vitro multispecies plaque-derived (mspd) biofilm model. | 2014 | 25263195 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| the effects of different orthodontic appliances upon microbial communities. | orthodontic appliances can promote accumulation of dental plaque, with associated enamel decalcification or gingival inflammation. the aim of this study was to examine longer-term microbiological changes during orthodontic treatment with fixed appliances. | 2014 | 24345204 |
| colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria. | biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola). | 2014 | 24949828 |
| microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. | the detection of special bacterial species in patients with periodontitis is considered to be useful for clinical diagnosis and treatment. the collection of subgingival plaque samples is the common way for the determination of periodontopathic bacteria. however, recently, salivary analysis has been discussed as an advantageous future diagnostic method for periodontitis because it offers simple quantitative sampling and the possibility to assess various bacteria. the aim of this cross-sectional s ... | 2014 | 24144271 |
| detection of periodontal pathogens in the patients with aortic aneurysm. | the occurrence and development of aortic aneurysm (aa) are associated with infection. some researchers have detected the dna of periodontal pathogens in aa samples in certain populations. however, it has not been done in chinese population. the objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of aa patients. | 2014 | 25430459 |