Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| synchronous and asynchronous presentations of auditory and visual signals: implications for control console design. | in this study, the effects of synchronous and asynchronous auditory and visual signal presentation on reaction times and response errors were examined to provide data for developing ergonomics recommendations for control console design. the results showed that synchronous presentation for combined visual and auditory stimulation facilitated responses, and shorter reaction times and higher response accuracies were obtained. when visual and auditory stimuli were presented synchronously but in oppo ... | 2006 | 16102721 |
| selecting small reserves in a human-dominated landscape: a case study of hong kong, china. | in this case study of a degraded tropical landscape, we examine how the protected area system in hong kong, china, should be modified to improve its efficiency in protecting the surprisingly rich biota. the challenge lies in the fine scale of site selection, and the absence of a core area with high species richness and rarity. site selection was first conducted in 1 km grid units by selecting hotspots and irreplaceable sites using field records for eight groups of species (amphibians, reptiles, ... | 2006 | 16102890 |
| metal contamination in urban, suburban, and country park soils of hong kong: a study based on gis and multivariate statistics. | the urban environment quality is of vital importance as the majority of people now live in cities. due to the continuous urbanisation and industrialisation in many parts of the world, metals are continuously emitted into the terrestrial environment and pose a great threat on human health. an extensive survey was conducted in the highly urbanised and commercialised hong kong island area (80.3 km2) of hong kong using a systematic sampling strategy of five soil samples per km2 in urban areas and tw ... | 2006 | 15913711 |
| avian influenza (h5n1): implications for intensive care. | as influenza a/h5n1 spreads around the globe the risk of an epidemic increases. | 2006 | 16568274 |
| demographic and lifestyle factors associated with dioxin-like activity (calux-teq) in human breast milk in hong kong. | maternal exposure to dioxins and related compounds before conception may affect the health of the fetus. to identify factors affecting dioxin body load in hong kong, in 2002, total dioxin-like activity was estimated in 250 individual milk samples at 2-6 weeks postpartum, from a representative group of primiparous mothers, aged 18-42 years (mean 29 +/- 5 years), by a chemically activated luciferase expression (calux) bioassay. associations between the calux-teq and 20 socio-demographic and dietar ... | 2006 | 16568753 |
| validating crash locations for quantitative spatial analysis: a gis-based approach. | in this paper, the spatial variables of the crash database in hong kong from 1993 to 2004 are validated. the proposed spatial data validation system makes use of three databases (the crash, road network and district board databases) and relies on gis to carry out most of the validation steps so that the human resource required for manually checking the accuracy of the spatial data can be enormously reduced. with the gis-based spatial data validation system, it was found that about 65-80% of the ... | 2006 | 16574045 |
| infectious diseases in children admitted from a residential child care centre. | to describe the pattern of infectious diseases among children admitted from a residential child care centre and to identify any unusual clusters of admissions. | 2006 | 16603779 |
| twenty years of clinical human immunodeficiency virus (hiv) and acquired immunodeficiency syndrome (aids) in hong kong. | to elucidate the development of human immunodeficiency virus (hiv) clinical care and research in hong kong. | 2006 | 16603781 |
| bird flu prevention. | 2006 | 16631878 | |
| evaluation of the effect of energy conservation techniques in the performance of activity of daily living tasks. | to determine whether energy conservation techniques during common activity of daily living tasks actually result in lower energy expenditure, and to document subjective comments regarding any differences in the perceived level of effort. | 2006 | 16634345 |
| an evaluation of nursing practice models in the context of the severe acute respiratory syndrome epidemic in hong kong: a preliminary study. | like other health-care workers, hong kong nurses had their professional knowledge and skills seriously challenged during the sars outbreak. could current nursing practices support the care of sars or sars-like patients in the future? if not, alternative practices would be needed. providing a preliminary understanding, this paper compares the conventional with different nursing delivery models in a simulated sars ward and focuses on nurses' efficiency, infection control practices and views of the ... | 2006 | 16684161 |
| hla-b67 may be a male-specific hla marker of susceptibility to relapsed childhood all in hong kong chinese and hla-a33 or hla-b17 signifies a higher presentation leukocytosis: a retrospective analysis on 53 transplant candidates (1989-2003). | we performed a retrospective analysis on the human leukocyte antigen (hla) data of 53 consecutive chinese patients with high-risk childhood acute lymphoblastic leukemia (all) diagnosed from 1989 to 2003. a significantly higher frequency of hla-b67 in the male relapse group of patients [or, 23.08; 95% ci, 5.31-100.36; p = 0.0042; for statistical significance after bonferroni correction (bc) p (bc) < 0.0083] was identified after bonferroni correction. although not surviving the bonferroni correcti ... | 2006 | 16710717 |
| influenza-related deaths and hospitalizations in hong kong: a subtropical area. | while influenza vaccination has been widely used in developed countries to reduce mortality and morbidity in high-risk populations, the lack of regional data on the health burden of influenza and the uncertainty of the applicability of data from temperate areas have been major impediments to establishing an evidence-based policy on the wider use of influenza vaccine in tropical and subtropical regions of the world. | 2006 | 16713608 |
| immune response to influenza vaccination in community-dwelling chinese elderly persons. | we investigated the immune antibody response to influenza vaccine in community-dwelling chinese elderly persons in hong kong. one hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. there was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (pr) (haemagglutination inhibition [hi] titre>or=1:40) and geometric mean titres (gmt) of the hi antibody titers. the pr, gmts and serologica ... | 2006 | 16713661 |
| prevalence of influenza vaccination and associated factors among community-dwelling hong kong residents of age 65 or above. | a total of 877 hong kong chinese community-dwelling elderly were telephone-interviewed. of them, 63.2% had heard of influenza vaccination (iv), 31.2% had ever had iv (of which 93.3% did so in the last 6 months) and 51.4% were inclined toward receiving free iv in the coming year. multivariate analyses showed that older age, perceptions of side effects, perceptions of effectiveness duration, and knowing where to get vaccinated were significantly associated with having ever been vaccinated. these v ... | 2006 | 16716461 |
| situational state balances and participation motivation in youth sport: a reversal theory perspective. | reversal theory (apter, 1982, 1989, ) is one of the motivational frameworks which attempts to examine human subjective experiences and behaviours. there are four dyads of metamotivational states (telic-paratelic, conformist-negativistic, autic-alloic, and mastery-sympathy) and individuals may prefer to be in one rather than the other of a dyad of states in a specific context such as sport participation (i.e. situational state balances). | 2006 | 16719969 |
| influence of different allelic variants of the cyp3a and abcb1 genes on the tacrolimus pharmacokinetic profile of chinese renal transplant recipients. | tacrolimus has a narrow therapeutic window and a wide interindividual variation in its pharmacokinetics. the cytochrome p450 3a (cyp3a) and the atp-binding cassette b1 (abcb1) genes play an important role in the tacrolimus disposition. therefore, the aim of this study was to evaluate whether cyp3a and abcb1 polymorphisms are associated with the area under the time concentration curve (auc0-12) calculated using a two time point sample strategy. the cyp3a and abcb1 genotypes were determined by rea ... | 2006 | 16753004 |
| experimental study of environmental tobacco smoke particles under actual indoor environment. | environmental tobacco smoke (ets) is a major source of human exposure to airborne particles. in order to provide more information necessary for human exposure investigations, the aim of the work presented here is to investigate experimentally the variation of the ets particle concentration and size distribution under an actual indoor environment, in a room of 30 m3, using human smokers. the effect of number of cigarettes and brands of cigarettes, the effect of sampling location and the effect of ... | 2006 | 16753201 |
| coronavirus hku1 and other coronavirus infections in hong kong. | we have recently described the discovery of a novel coronavirus, coronavirus hku1 (cov-hku1), associated with community-acquired pneumonia. however, the clinical spectrum of disease and the epidemiology of cov-hku1 infections in relation to infections with other respiratory viruses are unknown. in this 12-month prospective study, 4,181 nasopharyngeal aspirates from patients with acute respiratory tract infections were subjected to reverse transcription-pcrs specific for cov-hku1 and human corona ... | 2006 | 16757599 |
| comparative stigma of hiv/aids, sars, and tuberculosis in hong kong. | this study compares public stigma towards three types of infectious diseases- human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids), severe acute respiratory syndrome (sars), and tuberculosis (tb)-tests an attribution model of stigma, and explores the relationships between stigma and public attitudes towards government policies in hong kong. using a population-based telephone survey, 3011 hong kong chinese adults were randomly assigned to one of the three disease conditions ... | 2006 | 16766106 |
| formulaic expert method to integrate evaluation and valuation of heritage trees in compact city. | urban trees serve important environmental, social and economic functions, but similar to other natural endowments they are not customarily depicted in monetary terms. the needs to augment protection, funding and community support for urban greening call for proper valuation. heritage trees (hts), the cream of urban-tree stock, deserve special attention. existing assessment methods do not give justice to outstanding trees in compact cities deficient in high-caliber greenery, and to their social-c ... | 2006 | 16779581 |
| multiple-vehicle traffic accidents in hong kong. | 'multiple-vehicle traffic accident' refers to a crash between two or more moving objects. unlike single-vehicle accidents, not all drivers involving in a multiple-vehicle accident are responsible for the occurrence of the event. accordingly, variables such as road type, speed limit and number of vehicles involved in the accident are expected to play a much more important role in association with injury severity in multiple-vehicle accidents. to study the factors influencing injury severity of mu ... | 2006 | 16780781 |
| seasonal variation of air pollution index: hong kong case study. | air pollution is an important and popular topic in hong kong as concerns have been raised about the health impacts caused by vehicle exhausts in recent years. in hong kong, sulphur dioxide so2, nitrogen dioxide (no2), nitric oxide (no), carbon monoxide (co), and respirable suspended particulates (rsp) are major air pollutants caused by the dominant usage of diesel fuel by goods vehicles and buses. these major pollutants and the related secondary pollutant, e.g., ozone (o3), become and impose har ... | 2006 | 16325232 |
| influenza. | 2006 | 16858909 | |
| perceptions about status and modes of h5n1 transmission and associations with immediate behavioral responses in the hong kong general population. | perceptions and associated behavioral responses to h5n1 avian influenza were investigated. | 2006 | 16860379 |
| four x-chromosomal strs and their allele frequencies in a chinese population. | x-chromosomal markers are particularly useful for solving complex problems relating to kinship and deficiency paternity analysis. in the present study, population genetics data of four x-chromosomal short tandem repeats (strs) dxs8378, hprtb, dxs7423 and dxs7132 were obtained by analyzing 500 unrelated chinese individuals (250 males and 250 females). population genetics data obtained from the chinese were compared with those of the asian and european population. mutations in x-chromosomal marker ... | 2006 | 16860957 |
| allele frequencies and haplotypes of 12 y-str loci for the local chinese population in hong kong. | haplotype frequencies were established for 12 y-chromosome str loci, including all loci recommended by scientific working group on dna analysis methods y-str subcommittee (dys391, dys389i/ii, dys439, dys393, dys390, dys385a/b, dys438, dys19 and dys392) plus dys437, in the local chinese population in hong kong. in a sample of 481 unrelated males, it was possible to define 424 different haplotypes of which 388 were unique, 26 was found in two individuals, 2 were shared in three individuals, 5 were ... | 2006 | 16876356 |
| reducing the impact of the next influenza pandemic using household-based public health interventions. | the outbreak of highly pathogenic h5n1 influenza in domestic poultry and wild birds has caused global concern over the possible evolution of a novel human strain [1]. if such a strain emerges, and is not controlled at source [2,3], a pandemic is likely to result. health policy in most countries will then be focused on reducing morbidity and mortality. | 2006 | 16881729 |
| exon 3 polymorphisms of dopamine d4 receptor (drd4) gene and attention deficit hyperactivity disorder in chinese children. | dopamine d4 receptor (drd4) gene is implicated in the pathogenesis of attention deficit hyperactivity disorder (adhd). the 7-repeat allele of the variable-number-of-tandem-repeat (vntr) polymorphism in exon 3 has been reported to be associated with adhd. however, studies in chinese populations have yielded conflicting results. we therefore perform another study to investigate the association between adhd and drd4 gene polymorphism in chinese children in hong kong. in this prospective family-base ... | 2006 | 16917940 |
| methods for monitoring influenza surveillance data. | a variety of serfling-type statistical algorithms requiring long series of historical data, exclusively from temperate climate zones, have been proposed for automated monitoring of influenza sentinel surveillance data. we evaluated three alternative statistical approaches where alert thresholds are based on recent data in both temperate and subtropical regions. | 2006 | 16926216 |
| the large 386-nt deletion in sars-associated coronavirus: evidence for quasispecies? | the severe acute respiratory syndrome-associated coronavirus (sars-cov) is reported to have deletions of various sizes. recently, the large 386-nucleotide deletion (l386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from hong kong. in this study, archived specimens from 71 patients with sars who were admitted to the new territory east cluster hospitals in hong kong were analyzed to determine whether t ... | 2006 | 16941348 |
| recurrent kras codon 146 mutations in human colorectal cancer. | an activating point mutation in codon 12 of the hras gene was the first somatic point mutation identified in a human cancer and established the role of somatic mutations as the common driver of oncogenesis. since then, there have been over 11,000 mutations in the three ras (hras, kras and nras) genes in codons 12, 13 and 61 reported in the literature. we report here the identification of recurrent somatic missense mutations at alanine 146, a highly conserved residue in the guanine nucleotide bin ... | 2006 | 16969076 |
| health professionals and the international code of marketing of breast-milk substitutes. | 2006 | 17028365 | |
| clinical studies of immunomodulatory activities of yunzhi-danshen in patients with nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a prevalent tumor in hong kong. the immune system of such patients could be adversely affected during the course of conventional chemotherapy or radiotherapy. we investigated the immunomodulatory effects of traditional chinese medicine (tcm) yunzhi-danshen capsules in npc patients treated with radiotherapy. | 2006 | 17034283 |
| human papillomavirus dna and liquid-based cervical cytology cotesting in screening and follow-up patient groups. | to compare the use of human papillomavirus (hpv) dna and cervical cytology cotesting in screening and follow-up of patients with previous cervical abnormalities and to assess the significance of a positive hpv dna test result in re-screening of cytologically normal cases. | 2006 | 17152273 |
| bioinformatics research on the sars coronavirus (sars_cov) in china. | severe acute respiratory syndrome (sars) first appeared in 2002 in china, which fastly affected about 8000 patients over 29 countries and caused 774 fatalities. as its pathogen was identified as a new kind of coronavirus (sars_cov), its genome was quickly sequenced on several isolates. studies on its functional genomics were performed by combinatorial application of all the available bioinformatics tools and the development of new programs. in this way, it was found that the four proteins were a ... | 2006 | 17168762 |
| social competence as a positive youth development construct: conceptual bases and implications for curriculum development. | two major aspects of social competence were studied in this section: positive human relationships and clear self-identity. the concepts of human relationships and identity development are delineated. the importance of the development of a national identity for hong kong adolescents is also explained. the social competence program units focus on issues relating to national and racial identity, and human relationships (especially the resolution of interpersonal conflicts in the family and between ... | 2006 | 17068919 |
| human capital, social capital and social exclusion: impacts on the opportunity of households with youth to leave poverty. | based on a sample survey, this paper, analyzes the impact of human capital, social capital and social exclusion on the opportunity of hong kong families with youth members to leave poverty. educational attainment of the youth members and adult family members, as well as the quantity and quality of social networks were found to have significant positive impacts, while social exclusion from the labor market of the adult members was found to have significant negative impact on their opportunity to ... | 2006 | 17068934 |
| viral load, e2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia. | the clinical utility of human papillomavirus (hpv) load and integration status remains unclear. we applied refined methods to delineate the viral load, integration status, and lineage of 104 women with hpv-16 monotype infection, including 19 with normal cervices, 9 with histologically proven cervical intraepithelial neoplasia (cin) 1, 24 with cin 2, 27 with cin 3, and 25 with squamous cell carcinoma (scc). higher crude viral load, as determined by real-time polymerase chain reaction (pcr) target ... | 2006 | 17109343 |
| preparedness for influenza pandemic in hong kong nursing units. | to present preparedness planning for an influenza pandemic for two nursing subunits: nursing services in hospitals and schools of nursing in universities. | 2006 | 17181077 |
| a fatal case of chromobacterium violaceum septicemia in hong kong. | chromobacterium violaceum causes a rare infection in human, usually in tropical or subtropical areas. we report a fatal case of c. violaceum infection affecting a 40-year-old previously healthy man in hong kong. he presented with a wound infection and lymphadenitis. despite multiple antibiotic treatment, including ciprofloxacin, he succumbed shortly after admission to the hospital. we report the epidemiological investigation findings and discuss the possible sources of infection. physicians shou ... | 2006 | 17333774 |
| hong kong: appeal court affirms that law criminalizing buggery infringes rights of gay men. | 2006 | 17378019 | |
| precautions in ophthalmic practice in a hospital with a major acute sars outbreak: an experience from hong kong. | many new infectious diseases in humans have been derived from animal sources in the past 20 years. some are highly contagious and fatal. vaccination may not be available and antiviral drugs are not effective enough. infectious control is important in clinical medicine and in ophthalmology. severe acute respiratory syndrome (sars), as an example, is a highly contagious respiratory disease that has recently been reported in asia, north america, and europe. within a matter of weeks, the outbreak ha ... | 2006 | 15877099 |
| gender difference in achieving rate of maturity of the vesicoureteric junction. | our previous study on the doppler waveform of the urinary jet at the vesicoureteric junction (vuj) indicates that there is an active sphincteric mechanism in humans. we have also shown that there are immature and mature patterns of the jet, and the vuj matures around the age of 4 years. | 2007 | 17180364 |
| live poultry exposures, hong kong and hanoi, 2006. | since 1997, the largest epidemic of highly pathogenic avian influenza (h5n1) ever recorded has caused 172 human and several billion bird deaths. recently administered questionnaires determined that live poultry exposures have declined by approximately 63% in hong kong since 2004 and that, in vietnam, domestic backyard exposures to poultry are likely more important than retail exposures. | 2007 | 18214181 |
| any effect of cyp2c9 variants on warfarin clearance in chinese patients? | 2007 | 17479200 | |
| association between hla-b*1502 allele and antiepileptic drug-induced cutaneous reactions in han chinese. | a previous study conducted in taiwan found a 100% association between hla-b*1502 allele and carbamazepine-induced stevens-johnson syndrome (sjs) in han chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). we examined this association in 24 hong kong han chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (aeds). they were matched with 48 aed-tolerant controls. hla-b*1502 was associated wi ... | 2007 | 17509004 |
| association between hla-drb1 polymorphism, high-risk hpv infection and cervical neoplasia in southern chinese. | multiple determinants are involved in the progression of human papillomavirus (hpv)-infected cervical lesion to invasive cancer. human leukocyte antigen (hla) polymorphism seems to play a role. this study examined the association between hla-drb1 polymorphism, high-risk hpv infection, and the development of cervical neoplasia in southern chinese. three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade ii, 154 grade iii, and 173 invasive cancers) and 3 ... | 2007 | 17516530 |
| anthropometric evaluation for primary school furniture design. | musculoskeletal symptoms are one of the top ten health problems among schoolchildren in hong kong. whether or not these symptoms are related to school furniture has yet to be determined and published data on furniture size are lacking. the purpose of the study was to determine whether the design of furniture in schools is appropriate for children's anthropometry. a total of 214 volunteer subjects were recruited. this constituted 90% of the total number of primary 5 and 6 students in the studied ... | 2007 | 17536771 |
| universal antenatal human immunodeficiency virus (hiv) testing programme is cost-effective despite a low hiv prevalence in hong kong. | to evaluate the cost-effectiveness of universal antenatal human immunodeficiency virus (hiv) testing in hong kong. | 2007 | 17548908 |
| non-typhoid salmonella mycotic aneurysm of the aortic arch. | salmonella mycotic aneurysm is a rare but potentially fatal condition. mortality is high without timely intervention. the clinical presentation is protean and early diagnosis requires a high degree of clinical alertness. prompt surgical intervention and prolonged antimicrobial therapy are keys to successful treatment. we report an 81-year-old man with an atypical presentation of salmonella mycotic aneurysm in the aortic arch. the case highlights the need to evaluate all patients over 50 years wi ... | 2007 | 17548914 |
| patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis b carrier. | human papillomavirus (hpv) and hepatitis b virus (hbv) are known aetiology of cervical and hepatocellular carcinoma, respectively. both diseases share a similar clinical course, that is, the vast majority of those infected by these two viruses can eradicate the viruses spontaneously. a small sub-group who fails to clear the virus becomes chronic carrier and can progress to carcinoma many years later. we postulated that patients with pre-malignant or malignant cervical lesion are at increased ris ... | 2007 | 17550135 |
| deductive reasoning and creativity: a cross-cultural study. | the present cross-cultural study examined the relationship between deductive reasoning and creativity among college students (m age=20.4 yr., sd= .6) from hong kong (n=39) and the united states (n=38). participants performed tasks designed to measure deductive reasoning, creative writing, and insight problem-solving, all in verbal form. no correlation was found between the performance for deductive reasoning and creativity as measured by creative writing. insight problem-solving performance corr ... | 2007 | 17564227 |
| long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with bmt at first remission and hla-matched unrelated donor. | we analyzed the outcome of 108 adult acute lymphoblastic leukemia patients undergoing allogeneic bone marrow transplantation (bmt). philadelphia (ph) chromosome occurred in 35.2% patients at diagnosis. two-thirds of patients received allogeneic bmt in first complete remission (cr1) bmt. salvage bmt was performed in 21 and 16 patients at second complete remission (cr2) and beyond cr2. donors were human leukocyte antigen-identical siblings in 87 patients, and match-unrelated donors in 21 patients. ... | 2007 | 17572712 |
| variants conferring risk of atrial fibrillation on chromosome 4q25. | atrial fibrillation (af) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. it affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. recent studies have provided evidence of a genetic contribution to af. mutations in potassium-channel genes have been associated with familial af but account for only a small fraction of all cases of af. we have perf ... | 2007 | 17603472 |
| emerging occupational lung infections. | recent experiences of emerging infections, such as severe acute respiratory syndrome (sars) and avian influenza (h5n1), have highlighted the risks of serious pulmonary infections from occupational exposures. occupationally acquired human immunodeficiency virus (hiv) infection could also result in life-threatening, opportunistic lung infections as a result of host immunosuppression. these three occupationally acquired infections are major public health problems that carry with them enormous econo ... | 2007 | 17609045 |
| replication and identification of novel variants at tcf7l2 associated with type 2 diabetes in hong kong chinese. | variations at a large linkage disequilibrium (ld) block of transcription factor 7-like 2 gene (tcf7l2) were reported to be associated with type 2 diabetes (t2d) in icelandic, danish and european-american populations and further replicated in other populations of european, african, and asian ancestries. however, data for chinese and comprehensive survey of the whole gene are lacking. | 2007 | 17609304 |
| agreement between breast milk dioxin levels by calux bioassay and chemical analysis in a population survey in hong kong. | chemically-activated luciferase gene expression (calux) bioassay and gas chromatography/mass spectrometry (gc/ms) are used to determine dioxin levels in food and humans. valid measures of the agreement between the two methods would improve interpretation of bioassay results. paired breast milk samples from 250 mothers, as 11 pooled samples, were analysed by gc/ms for total who-teq (7 polychlorinated dibenzo-para-dioxins, 10 polychlorinated dibenzofurans and 12 dioxin-like polychlorinated bipheny ... | 2007 | 17618674 |
| spatial distribution of heavy metals in hong kong's marine sediments and their human impacts: a gis-based chemometric approach. | a geographic information system (gis)-based chemometric approach was applied to investigate the spatial distribution patterns of heavy metals in marine sediments and to identify spatial human impacts on global and local scales. twelve metals (zn, v, ni, mn, pb, cu, cd, ba, hg, fe, cr and al) were surveyed twice annually at 59 sites in hong kong from 1998 to 2004. cluster analysis classified the entire coastal area into three areas on a global scale, representing different pollution levels. backw ... | 2007 | 17624377 |
| molecular analysis of a chromosome 4 inversion segregating in a large schizophrenia kindred from hong kong. | the present study looks at a paracentric inversion on chromosome 4 [inv(4)(q13;q25)] in members of a large schizophrenia kindred from hong kong, and the possibility of a susceptibility gene for schizophrenia at one of the inversion breakpoints. fluorescence in situ hybridization with bac and fosmid clones was used to determine the location of the 4q13 and 4q25 breakpoints, however bioinformatic analysis indicated that no known genes are directly disrupted by the breakpoints. we identified severa ... | 2007 | 17644315 |
| women's attitudes on human papillomavirus vaccination to their daughters. | this study assessed the impact of an information pamphlet on acceptance of human papillomavirus (hpv) vaccine in chinese women. the pamphlet increased the self-perceived knowledge on cervical cancer and hpv of the study subjects and had a positive influence on women accepting hpv vaccination for their daughters (p < .001). | 2007 | 17659226 |
| the potential impact of a prophylactic vaccine for human papillomavirus on the current cervical screening programme in hong kong. | to review and summarise current controversies in cervical screening in hong kong and discuss the potential impact of prophylactic human papillomavirus vaccination. | 2007 | 17664535 |
| factors associated with early hospital discharge of adult influenza patients. | understanding factors affecting length of hospital stay (los) in patients with severe influenza may improve their management. | 2007 | 17668558 |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| beliefs about cervical cancer and human papillomavirus (hpv) and acceptability of hpv vaccination among chinese women in hong kong. | to assess the knowledge and beliefs on cervical cancer and hpv infection and to evaluate the acceptability of hpv vaccination among chinese women. | 2007 | 17707077 |
| isolation of laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in hong kong. | freshwater fish has been found to be the reservoir of laribacter hongkongensis, a recently discovered bacterium associated with community-acquired gastroenteritis. however, little is known about the ecology of this bacterium in the aquatic environment. we carried out a surveillance study to investigate the presence of l. hongkongensis in water and freshwater fish from 10 drinking water reservoirs in hong kong. | 2007 | 17714383 |
| clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in hong kong. | human bocavirus (hbov) is a recently discovered parvovirus associated with respiratory tract infections in children. we conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (npas) and fecal samples. | 2007 | 17763318 |
| comparison of two automated nucleic acid testing systems for simultaneous detection of human immunodeficiency virus and hepatitis c virus rna and hepatitis b virus dna. | recently developed nucleic acid testing (nat) assays incorporating simultaneous detection of human immunodeficiency virus (hiv), hepatitis c virus (hcv), and hepatitis b virus (hbv) have made hbv nat screening more feasible for blood services. this study compared the performance of two "multiplex" nat assays and their automated testing platforms. | 2007 | 17880602 |
| impact of sars on avian influenza preparedness in healthcare workers. | sars was an unprecedented outbreak which brought about 1,755 infections and 302 deaths in hong kong. the similarity of sars and avian influenza prompted us to examine the relationship between sars experience and preparedness on a potential avian influenza outbreak. | 2007 | 17882357 |
| co-circulation of human metapneumovirus and sars-associated coronavirus during a major nosocomial sars outbreak in hong kong. | the clinico-epidemiological significance of human metapneumovirus (hmpv) detected during the sars outbreak is unknown. | 2007 | 17936066 |
| cyclic peptides from an endophytic fungus obtained from a mangrove leaf (kandelia candel). | two new cyclic depsipeptides, 1962a (1) and 1962b (2), along with the three known cyclodipeptides cyclo-(leu-tyr) (3), cyclo-(phe-gly) (4), and cyclo-(leu-leu) (5) were isolated from the fermentation broth of the mangrove endophytic fungus (no. 1962) isolated from an old leaf of kandelia candel collected in hong kong. through spectroscopic experimentation, x-ray crystallographic analysis, and acid hydrolysis followed by chiral hplc analysis, their structures were established to be 1962a, cyclo-( ... | 2007 | 17944538 |
| neurologic complications in children hospitalized with influenza: comparison between usa and hong kong. | 2007 | 17961673 | |
| rhinovirus infection in hospitalized children in hong kong: a prospective study. | to analyze the clinical features and estimate the hospitalization disease burden of rhinovirus infection in children in hong kong. | 2007 | 17984805 |
| theoretically estimated risk of severe acute respiratory syndrome transmission through blood transfusion during an epidemic in shenzhen, guangdong, china in 2003. | severe acute respiratory syndrome (sars) is a newly recognized infectious disease that caused an outbreak in south china in 2003. the cause of sars was identified as a novel coronavirus (cov). the existence of asymptomatic seroconvertors and the detection of the sars-cov rna in plasma during the course of infection all suggest that sars could, as least theoretically, be transmitted by transfusion. an estimate of the risk of sars transmission through blood transfusion will contribute to decisions ... | 2007 | 18036985 |
| iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | to describe the iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | 2007 | 18053285 |
| prenatal influenza exposure and delivery complications: implications for the development of schizophrenia. | this study assessed prenatal influenza exposure in relation to pregnancy complications and delivery complications. participants of this study consisted of a community sample of all mothers of 1,795 children who were a birth cohort recruited at age 3 in a prospective longitudinal project in mauritius. the onset of the 1968-1972 a2/hong kong influenza epidemic in january 1970 was established from officially published death rates and newspaper records. data on pregnancy and delivery complications w ... | 2007 | 19241651 |
| chinese widowers' self-perception of growth: an exploratory study. | presence of growth after traumatic events was introduced to the academic community about a decade ago (tedeschi & calhoun, 1995). from the conventionally neglected perspective of chinese widowers, this paper reports seventeen chinese widowers' views on growth after conjugal loss. findings seem to suggest that chinese widowers would define growth as human learning, a definition probably influenced by confucian teachings. furthermore, contrary to claims made by tedeschi and calhoun (2004), it was ... | 2007 | 18928081 |
| evaluation of an in-house genotyping resistance test for hiv-1 drug resistance interpretation and genotyping. | the human immunodeficiency virus type 1 (hiv-1) genotyping resistance test (grt) has been considered essential for hiv-1 drug resistance monitoring. however, it is not commonly used in some developing countries in asia and africa due to its high running cost. | 2007 | 17449318 |
| new evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. | our previous studies of tonsillar cancers from new south wales, australia, and jilin province in the north-east of china, provided evidence that the proportion of these cancers attributable to human papillomavirus (hpv) varies geographically. this study provides the first data on hpv in tonsillar cancers from hong kong. | 2007 | 17454751 |
| a qualitative study on the comfort and fit of ladies' dress shoes. | the perceived differences between comfortable and uncomfortable shoes and the fit preferences in the different regions of ladies' shoes were explored. twenty hong kong chinese females participated in the study. each participant wore and rated the different aspects of their own comfortable and uncomfortable shoes. the wilcoxon signed rank tests showed significant differences in ten perceived characteristics between the comfortable and uncomfortable shoes. among the ten were tactile, auditory and ... | 2007 | 17353001 |
| anticipated and current preventive behaviors in response to an anticipated human-to-human h5n1 epidemic in the hong kong chinese general population. | the prevalence of self-reported preventive behaviors in response to an anticipated local human-to-human h5n1 transmission outbreak and factors associated with such behaviors have not been examined. | 2007 | 17359545 |
| vitamin d receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the mros study in sweden and hong kong. | the vdr is a prime candidate gene for osteoporosis. here, we studied three common vdr haplotypes in relation to bone phenotypes in 5014 participants of the global mros study. we also studied the relative expression of the haplotypes in human bone cells. one haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. | 2007 | 17371163 |
| tropism of avian influenza a (h5n1) in the upper and lower respiratory tract. | poor human-to-human transmission of influenza a h5n1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. we now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with h5n1 viruses in spite of an apparent lack of these receptors. | 2007 | 17206149 |
| phenotypic and population differences in the association between cilp and lumbar disc disease. | lumbar disc disease (ldd) is one of the leading causes of disability in the working-age population. a functional single-nucleotide polymorphism (snp), +1184t-->c, in exon 8 of the cartilage intermediate layer protein gene (cilp) was recently identified as a risk factor for ldd in the japanese population (odds ratio (or) 1.61, 95% ci 1.31 to 1.98), with implications for impaired transforming growth factorbeta1 signalling. | 2007 | 17220213 |
| alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. | accurate and precise estimates of the incubation distribution of novel, emerging infectious diseases are vital to inform public health policy and to parameterize mathematical models. | 2007 | 17235210 |
| cross-border truck drivers in hong kong: their psychological health, sexual dysfunctions and sexual risk behaviors. | due to their job nature, cross-border truck drivers working between hong kong and china are exposed to many health risks. the aim of this study was to find out the impact of their occupation on their psychological health and sexual dysfunction and to assess their sexual risk behaviors. | 2007 | 17241250 |
| deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. | mannan-binding lectin (mbl) and ficolins distinguish between self, non-self and altered-self by recognizing patterns of ligands on the surface of microorganisms or aberrant cells. when this happens mbl-associated serine protease-2 (masp-2) is activated and cleaves complement factors to start inflammatory actions. we examined human populations for masp-2 levels, masp-2 function and for the presence of mutations in coding exons of masp2. the masp-2 levels were lowest in africans from zambia (media ... | 2007 | 17252003 |
| perceptions related to human avian influenza and their associations with anticipated psychological and behavioral responses at the onset of outbreak in the hong kong chinese general population. | anticipated psychological responses and perceptions of risk have not been examined prior to the outbreak of an epidemic. | 2007 | 17276790 |
| olanzapine-induced diabetic ketoacidosis in a chinese man. | we present a case report of a 22-year-old chinese man with schizophrenia and dissocial personality disorder who was normoglycaemic before taking olanzapine. after commencing olanzapine he developed diabetic ketoacidosis and was managed in the intensive care unit of a general hospital. olanzapine was stopped and replaced by haloperidol 5 mg/day. he was put on a strict 1500 kcal diabetic diet and required insulin injections to maintain a normal blood sugar level despite cessation of olanzapine for ... | 2007 | 17277396 |
| trace metals and organochlorines in the bamboo shark chiloscyllium plagiosum from the southern waters of hong kong, china. | the bamboo shark chiloscyllium plagiosum is an abundant benthic species along the shallow continental shelf of southeast asia. it is commonly taken by fishermen in china, india, taiwan and thailand for human consumption. this study measured trace metal and organochlorine concentrations in c. plagiosum collected from the southern waters of hong kong, china. metals (ag, cd, cr, cu, mn, ni, pb and zn) were measured in three different tissues: dorsal muscle, spleen and liver. polychlorinated bipheny ... | 2007 | 17320935 |
| studies on the expression of the deleted kir2ds4*003 gene product and distribution of kir2ds4 deleted and nondeleted versions in different populations. | a kir2ds4 deletion variant allele, previously identified through killer immunoglobulinlike receptor (kir) polymerase chain reaction-sequence-specific oligonucleotide probe (pcr-ssop) typing, was functionally investigated using an in vitro cell line model system and in vivo protein expression studies. the kir2ds4 deletion variant has previously been found in 80% of individuals from northern ireland, indicating that it is present at a high incidence in this population. it differs from the normal k ... | 2007 | 17321903 |
| pollutants in hong kong soils: polycyclic aromatic hydrocarbons. | an extensive soil survey was carried out to study the polycyclic aromatic hydrocarbon (pah) contaminations in 138 soil samples collected throughout hong kong. results demonstrated that there were low levels of pah contaminations (median of summation operator 16us epa pahs=140 microg kg(-1)) for all land uses (urban park, greening area, country park, rural area, restored landfill, agricultural farmland, orchard farm, crematorium, industrial and near highway area). however, localized hotspots were ... | 2007 | 17109918 |
| evaluation of nuclisens easyq hiv-1 assay for quantification of hiv-1 subtypes prevalent in south-east asia. | monitoring anti-retroviral therapy requires that viral load assays for human immunodeficiency virus type 1 (hiv-1) be applicable to diverse hiv-1 subtypes. | 2007 | 17110162 |
| characterizing 56 complete sars-cov s-gene sequences from hong kong. | the spike glycoprotein (s) gene of the severe acute respiratory syndrome-associated coronavirus (sars-cov) has been useful in analyzing the molecular epidemiology of the 2003 sars outbreaks. | 2007 | 17112780 |
| catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from hong kong and canada. | four bacterial isolates were recovered from the blood cultures of four patients, two of whom were from hong kong and two of whom were from canada. the two hong kong strains were isolated from a 48-year-old man with intestinal obstruction and secondary sepsis (strain hku16t) and from a 39-year-old man with acute appendicitis (strain hku17), while the two canadian strains were isolated from a 74-year-old man with biliary sepsis (strain ca1) and from a 66-year-old woman with metastatic carcinoma an ... | 2007 | 17122022 |
| the study of sequence configuration and functional impact of the (ac)n(at)xty motif in human beta-globin gene promoter. | in this report we examine the (ac)n(at)xty motif residing -530 bp 5' upstream of the beta-globin gene in chinese thalassaemic patients. this motif is a putative binding site for a repressor protein, termed beta protein 1 (bp1) (berg et al., nucleic acids res 1989;17:8833-8852). variations in the (ac)n(at)xty repeats affect the binding affinity of bp1, thereby altering the expression of the beta-globin gene. eight different configurations of this repeat motif are identified in our population of c ... | 2007 | 17133428 |
| first-trimester combined screening for trisomy 21 in a predominantly chinese population. | to examine the effectiveness of first-trimester fetal trisomy 21 screening using a combination of maternal age, nuchal translucency thickness (nt) and maternal serum free beta-human chorionic gonadotropin (beta-hcg) and pregnancy-associated plasma protein-a (papp-a) levels in a predominantly chinese population in hong kong. | 2007 | 17171632 |
| identification of molecular markers and signaling pathway in endometrial cancer in hong kong chinese women by genome-wide gene expression profiling. | endometrial cancer is the third most common gynecologic malignancy and the ninth most common malignancy for females overall in hong kong. approximately 80% or more of these cancers are endometrioid endometrial adenocarcinomas. the aim of this study was to reveal genes contributing to the development of endometrioid endometrial cancer, which may impact diagnosis, prognosis and treatment of the disease. whole-genome gene expression analysis was completed for a set of 55 microdissected sporadic end ... | 2007 | 17043662 |
| risk assessment of trace elements in the stomach contents of indo-pacific humpback dolphins and finless porpoises in hong kong waters. | the potential health risks due to inorganic substances, mainly metals, was evaluated for the two resident marine mammals in hong kong, the indo-pacific humpback dolphin (sousa chinensis) and the finless porpoise (neophocaena phocaenoides). the stomachs from the carcasses of twelve stranded dolphins and fifteen stranded porpoises were collected and the contents examined. concentrations of thirteen trace elements (ag, as, cd, co, cr, cs, cu, hg, mn, ni, se, v and zn) were determined by inductively ... | 2007 | 16979696 |
| real-time epidemic forecasting for pandemic influenza. | the ongoing worldwide spread of the h5n1 influenza virus in birds has increased concerns of a new human influenza pandemic and a number of surveillance initiatives are planned, or are in place, to monitor the impact of a pandemic in near real-time. using epidemiological data collected during the early stages of an outbreak, we show how the timing of the maximum prevalence of the pandemic wave, along with its amplitude and duration, might be predicted by fitting a mass-action epidemic model to th ... | 2007 | 16928287 |