Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| synchronous and asynchronous presentations of auditory and visual signals: implications for control console design. | in this study, the effects of synchronous and asynchronous auditory and visual signal presentation on reaction times and response errors were examined to provide data for developing ergonomics recommendations for control console design. the results showed that synchronous presentation for combined visual and auditory stimulation facilitated responses, and shorter reaction times and higher response accuracies were obtained. when visual and auditory stimuli were presented synchronously but in oppo ... | 2006 | 16102721 |
| selecting small reserves in a human-dominated landscape: a case study of hong kong, china. | in this case study of a degraded tropical landscape, we examine how the protected area system in hong kong, china, should be modified to improve its efficiency in protecting the surprisingly rich biota. the challenge lies in the fine scale of site selection, and the absence of a core area with high species richness and rarity. site selection was first conducted in 1 km grid units by selecting hotspots and irreplaceable sites using field records for eight groups of species (amphibians, reptiles, ... | 2006 | 16102890 |
| avian influenza (h5n1): implications for intensive care. | as influenza a/h5n1 spreads around the globe the risk of an epidemic increases. | 2006 | 16568274 |
| demographic and lifestyle factors associated with dioxin-like activity (calux-teq) in human breast milk in hong kong. | maternal exposure to dioxins and related compounds before conception may affect the health of the fetus. to identify factors affecting dioxin body load in hong kong, in 2002, total dioxin-like activity was estimated in 250 individual milk samples at 2-6 weeks postpartum, from a representative group of primiparous mothers, aged 18-42 years (mean 29 +/- 5 years), by a chemically activated luciferase expression (calux) bioassay. associations between the calux-teq and 20 socio-demographic and dietar ... | 2006 | 16568753 |
| social competence as a positive youth development construct: conceptual bases and implications for curriculum development. | two major aspects of social competence were studied in this section: positive human relationships and clear self-identity. the concepts of human relationships and identity development are delineated. the importance of the development of a national identity for hong kong adolescents is also explained. the social competence program units focus on issues relating to national and racial identity, and human relationships (especially the resolution of interpersonal conflicts in the family and between ... | 2006 | 17068919 |
| human capital, social capital and social exclusion: impacts on the opportunity of households with youth to leave poverty. | based on a sample survey, this paper, analyzes the impact of human capital, social capital and social exclusion on the opportunity of hong kong families with youth members to leave poverty. educational attainment of the youth members and adult family members, as well as the quantity and quality of social networks were found to have significant positive impacts, while social exclusion from the labor market of the adult members was found to have significant negative impact on their opportunity to ... | 2006 | 17068934 |
| validating crash locations for quantitative spatial analysis: a gis-based approach. | in this paper, the spatial variables of the crash database in hong kong from 1993 to 2004 are validated. the proposed spatial data validation system makes use of three databases (the crash, road network and district board databases) and relies on gis to carry out most of the validation steps so that the human resource required for manually checking the accuracy of the spatial data can be enormously reduced. with the gis-based spatial data validation system, it was found that about 65-80% of the ... | 2006 | 16574045 |
| infectious diseases in children admitted from a residential child care centre. | to describe the pattern of infectious diseases among children admitted from a residential child care centre and to identify any unusual clusters of admissions. | 2006 | 16603779 |
| twenty years of clinical human immunodeficiency virus (hiv) and acquired immunodeficiency syndrome (aids) in hong kong. | to elucidate the development of human immunodeficiency virus (hiv) clinical care and research in hong kong. | 2006 | 16603781 |
| prevalence of influenza vaccination and associated factors among community-dwelling hong kong residents of age 65 or above. | a total of 877 hong kong chinese community-dwelling elderly were telephone-interviewed. of them, 63.2% had heard of influenza vaccination (iv), 31.2% had ever had iv (of which 93.3% did so in the last 6 months) and 51.4% were inclined toward receiving free iv in the coming year. multivariate analyses showed that older age, perceptions of side effects, perceptions of effectiveness duration, and knowing where to get vaccinated were significantly associated with having ever been vaccinated. these v ... | 2006 | 16716461 |
| situational state balances and participation motivation in youth sport: a reversal theory perspective. | reversal theory (apter, 1982, 1989, ) is one of the motivational frameworks which attempts to examine human subjective experiences and behaviours. there are four dyads of metamotivational states (telic-paratelic, conformist-negativistic, autic-alloic, and mastery-sympathy) and individuals may prefer to be in one rather than the other of a dyad of states in a specific context such as sport participation (i.e. situational state balances). | 2006 | 16719969 |
| influence of different allelic variants of the cyp3a and abcb1 genes on the tacrolimus pharmacokinetic profile of chinese renal transplant recipients. | tacrolimus has a narrow therapeutic window and a wide interindividual variation in its pharmacokinetics. the cytochrome p450 3a (cyp3a) and the atp-binding cassette b1 (abcb1) genes play an important role in the tacrolimus disposition. therefore, the aim of this study was to evaluate whether cyp3a and abcb1 polymorphisms are associated with the area under the time concentration curve (auc0-12) calculated using a two time point sample strategy. the cyp3a and abcb1 genotypes were determined by rea ... | 2006 | 16753004 |
| comparative stigma of hiv/aids, sars, and tuberculosis in hong kong. | this study compares public stigma towards three types of infectious diseases- human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids), severe acute respiratory syndrome (sars), and tuberculosis (tb)-tests an attribution model of stigma, and explores the relationships between stigma and public attitudes towards government policies in hong kong. using a population-based telephone survey, 3011 hong kong chinese adults were randomly assigned to one of the three disease conditions ... | 2006 | 16766106 |
| multiple-vehicle traffic accidents in hong kong. | 'multiple-vehicle traffic accident' refers to a crash between two or more moving objects. unlike single-vehicle accidents, not all drivers involving in a multiple-vehicle accident are responsible for the occurrence of the event. accordingly, variables such as road type, speed limit and number of vehicles involved in the accident are expected to play a much more important role in association with injury severity in multiple-vehicle accidents. to study the factors influencing injury severity of mu ... | 2006 | 16780781 |
| immune response to influenza vaccination in community-dwelling chinese elderly persons. | we investigated the immune antibody response to influenza vaccine in community-dwelling chinese elderly persons in hong kong. one hundred and twenty-eight subjects were recruited in a single-blind, randomized, and placebo-controlled trial. there was no significant baseline difference between the vaccine and placebo groups regarding the seroprotection rates (pr) (haemagglutination inhibition [hi] titre>or=1:40) and geometric mean titres (gmt) of the hi antibody titers. the pr, gmts and serologica ... | 2006 | 16713661 |
| experimental study of environmental tobacco smoke particles under actual indoor environment. | environmental tobacco smoke (ets) is a major source of human exposure to airborne particles. in order to provide more information necessary for human exposure investigations, the aim of the work presented here is to investigate experimentally the variation of the ets particle concentration and size distribution under an actual indoor environment, in a room of 30 m3, using human smokers. the effect of number of cigarettes and brands of cigarettes, the effect of sampling location and the effect of ... | 2006 | 16753201 |
| an evaluation of nursing practice models in the context of the severe acute respiratory syndrome epidemic in hong kong: a preliminary study. | like other health-care workers, hong kong nurses had their professional knowledge and skills seriously challenged during the sars outbreak. could current nursing practices support the care of sars or sars-like patients in the future? if not, alternative practices would be needed. providing a preliminary understanding, this paper compares the conventional with different nursing delivery models in a simulated sars ward and focuses on nurses' efficiency, infection control practices and views of the ... | 2006 | 16684161 |
| perceptions about status and modes of h5n1 transmission and associations with immediate behavioral responses in the hong kong general population. | perceptions and associated behavioral responses to h5n1 avian influenza were investigated. | 2006 | 16860379 |
| homozygous l-sign (clec4m) plays a protective role in sars coronavirus infection. | severe acute respiratory syndrome (sars) is caused by infection of a previously undescribed coronavirus (cov). l-sign, encoded by clec4m (also known as cd209l), is a sars-cov binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. our genetic risk association study shows that individuals homozygous for clec4m tandem repeats are less susceptible to sars infection. l-sign is expressed in both non-sars and sars-cov-infected lung. compar ... | 2006 | 16369534 |
| breast milk dioxins in hong kong and pearl river delta. | there are no previous reports from south china on chemically determined polychlorinated dibenzo-para-dioxins (pcdds), polychlorinated dibenzofurans (pcdfs), and dioxin-like polychlorinated biphenyls (pcbs) in human breast milk expressed as world health organization (who) toxic equivalents (teqs). in a 2002-2003 who exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in hong kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 pcdd/f and diox ... | 2006 | 16451855 |
| epidemiology and clinical features of sporadic hepatitis e as compared with hepatitis a. | to compare the epidemiology and clinical features of two enterically transmitted hepatitis, namely hepatitis e and hepatitis a. | 2006 | 16454833 |
| reducing the impact of the next influenza pandemic using household-based public health interventions. | the outbreak of highly pathogenic h5n1 influenza in domestic poultry and wild birds has caused global concern over the possible evolution of a novel human strain [1]. if such a strain emerges, and is not controlled at source [2,3], a pandemic is likely to result. health policy in most countries will then be focused on reducing morbidity and mortality. | 2006 | 16881729 |
| avian influenza: risk, preparedness and the roles of public health nurses in hong kong. | this paper provides an overview of the hong kong government's influenza preparedness plan and the key roles of public health nurses in that plan. the part played by hong kong public health nurses in the management of the avian influenza outbreak in hong kong in 1997 and the sudden acute respiratory syndrome outbreak in 2003, together with the capacity-building work they are now undertaking in preparing for an influenza pandemic, highlight their crucial role in public health. recent strengthening ... | 2006 | 16494661 |
| photorealistic virtual anatomy based on chinese visible human data. | virtual reality based learning of human anatomy is feasible when a database of 3d organ models is available for the learner to explore, visualize, and dissect in virtual space interactively. in this article, we present our latest work on photorealistic virtual anatomy applications based on the chinese visible human (cvh) data. we have focused on the development of state-of-the-art virtual environments that feature interactive photo-realistic visualization and dissection of virtual anatomical mod ... | 2006 | 16506219 |
| [hong kong and the bird flu ]. | 2006 | 16512010 | |
| influenza-related deaths and hospitalizations in hong kong: a subtropical area. | while influenza vaccination has been widely used in developed countries to reduce mortality and morbidity in high-risk populations, the lack of regional data on the health burden of influenza and the uncertainty of the applicability of data from temperate areas have been major impediments to establishing an evidence-based policy on the wider use of influenza vaccine in tropical and subtropical regions of the world. | 2006 | 16713608 |
| influenza-associated hospitalization in a subtropical city. | the impact of influenza on morbidity and hospitalization in the tropics and subtropics is poorly quantified. uniquely, the hong kong special administrative region has computerized hospital discharge diagnoses on 95% of total bed days, allowing disease burden for a well-defined population to be accurately assessed. | 2006 | 16515368 |
| distinct epidermal growth factor receptor and kras mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. | this study evaluated the mutational profile of epidermal growth factor receptor (egfr) and kras in non-small cell lung cancers in hong kong and determined their relation with smoking history and other clinicopathologic features. | 2006 | 16533793 |
| coronavirus hku1 and other coronavirus infections in hong kong. | we have recently described the discovery of a novel coronavirus, coronavirus hku1 (cov-hku1), associated with community-acquired pneumonia. however, the clinical spectrum of disease and the epidemiology of cov-hku1 infections in relation to infections with other respiratory viruses are unknown. in this 12-month prospective study, 4,181 nasopharyngeal aspirates from patients with acute respiratory tract infections were subjected to reverse transcription-pcrs specific for cov-hku1 and human corona ... | 2006 | 16757599 |
| hla-b67 may be a male-specific hla marker of susceptibility to relapsed childhood all in hong kong chinese and hla-a33 or hla-b17 signifies a higher presentation leukocytosis: a retrospective analysis on 53 transplant candidates (1989-2003). | we performed a retrospective analysis on the human leukocyte antigen (hla) data of 53 consecutive chinese patients with high-risk childhood acute lymphoblastic leukemia (all) diagnosed from 1989 to 2003. a significantly higher frequency of hla-b67 in the male relapse group of patients [or, 23.08; 95% ci, 5.31-100.36; p = 0.0042; for statistical significance after bonferroni correction (bc) p (bc) < 0.0083] was identified after bonferroni correction. although not surviving the bonferroni correcti ... | 2006 | 16710717 |
| bird flu prevention. | 2006 | 16631878 | |
| evaluation of the effect of energy conservation techniques in the performance of activity of daily living tasks. | to determine whether energy conservation techniques during common activity of daily living tasks actually result in lower energy expenditure, and to document subjective comments regarding any differences in the perceived level of effort. | 2006 | 16634345 |
| seasonal variation of air pollution index: hong kong case study. | air pollution is an important and popular topic in hong kong as concerns have been raised about the health impacts caused by vehicle exhausts in recent years. in hong kong, sulphur dioxide so2, nitrogen dioxide (no2), nitric oxide (no), carbon monoxide (co), and respirable suspended particulates (rsp) are major air pollutants caused by the dominant usage of diesel fuel by goods vehicles and buses. these major pollutants and the related secondary pollutant, e.g., ozone (o3), become and impose har ... | 2006 | 16325232 |
| pneumocystis carinii pneumonia in hong kong: a 10 year retrospective study. | a retrospective review was performed of patients diagnosed with pneumocystis carinii pneumonia (pcp) from 1994 to 2003 at the prince of wales hospital in hong kong. eighteen patients were identified. six (33.3%) were co-infected with human immunodeficiency virus (hiv). the remaining 12 non-hiv-infected patients had underlying diseases: three post-renal transplant recipients, three with haematological malignancies, two with auto-immune diseases, two with renal diseases, one with hepatocellular ca ... | 2006 | 16388034 |
| metal contamination in urban, suburban, and country park soils of hong kong: a study based on gis and multivariate statistics. | the urban environment quality is of vital importance as the majority of people now live in cities. due to the continuous urbanisation and industrialisation in many parts of the world, metals are continuously emitted into the terrestrial environment and pose a great threat on human health. an extensive survey was conducted in the highly urbanised and commercialised hong kong island area (80.3 km2) of hong kong using a systematic sampling strategy of five soil samples per km2 in urban areas and tw ... | 2006 | 15913711 |
| semi-automatic segmentation and tracking of cvh data. | construction of speed function is crucial in applying level set method for medical image segmentation. we present a unified approach for segmenting and tracking of the high-resolution chinese visible human (cvh) data. the underlying link of these two parts relies on the proposed variational framework for the speed function. our proposed method can be applied to segmenting the first slice of the volume data, in the first step; it can also be adapted to track the boundaries of the homogeneous orga ... | 2006 | 16404094 |
| hla-b alleles, high-risk hpv infection and risk for cervical neoplasia in southern chinese women. | a population-based study was conducted on 256 southern chinese with cervical intraepithelial neoplasia grade iii (cin iii) or invasive cervical cancer (icc) and on 258 controls to examine the associations between hla-b alleles, infection with high-risk human papillomaviruses (hpvs) and the development of cervical neoplasia. hla-b15 was found to be protective for cin iii/icc overall (p(corrected) = 0.003), and for hpv52-positive cin iii/icc (p(corrected) = 0.003). a marginal protective effect of ... | 2006 | 16206270 |
| risk assessment of heavy metal contamination in shrimp farming in mai po nature reserve, hong kong. | an ecological survey was carried out to determine the sediment concentrations of nutrients and heavy metals and bioaccumulation of heavy metals in fish and shrimp including tilapia (oreochromis mossambicus x o. nilotica), grey mullet (mugil cephalus), gei wai shrimp (metapenaeus ensis) and caridean shrimp (macrobrachium nipponensis) in the traditional tidal shrimp ponds (gei wais) of mai po nature reserve, hong kong. the sediments collected from the landward sites contained higher nutrient conte ... | 2006 | 16528597 |
| detection of hong kong 97-like h5n1 influenza viruses from eggs of vietnamese waterfowl. | three h5n1 influenza viruses were isolated from shell washes of duck and goose eggs confiscated from travelers coming from vietnam. all eight gene segments of these viruses share high sequence identity with the h5n1 avian influenza viruses that caused outbreaks in poultry and humans in hong kong in 1997. animal studies indicate that these isolated viruses are able to replicate in mouse lung and could be found in the organs of ducks without causing any clinical signs or death. however, the viruse ... | 2006 | 16532371 |
| influenza pandemics of the 20th century. | three worldwide (pandemic) outbreaks of influenza occurred in the 20th century: in 1918, 1957, and 1968. the latter 2 were in the era of modern virology and most thoroughly characterized. all 3 have been informally identified by their presumed sites of origin as spanish, asian, and hong kong influenza, respectively. they are now known to represent 3 different antigenic subtypes of influenza a virus: h1n1, h2n2, and h3n2, respectively. not classified as true pandemics are 3 notable epidemics: a p ... | 2006 | 16494710 |
| is hong kong ground zero for the next avian influenza pandemic? | 2006 | 16495598 | |
| influenza in tropical regions. | 2006 | 16509764 | |
| association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17. | genome scan in chinese revealed an association of blood pressure with the microsatellite marker d17s1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (aoms2) at 17p12 on chromosome 17. we previously reported that d17s1303 was associated with hypertension and obesity. therefore, we studied 10 single nucleotide polymorphisms (snp) within 3 kb of d17s1303. one hundred and eighty hypertensive subjects (91 men, 89 women, age 53+/-12 years) and 180 normotensiv ... | 2006 | 16511504 |
| alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. | accurate and precise estimates of the incubation distribution of novel, emerging infectious diseases are vital to inform public health policy and to parameterize mathematical models. | 2007 | 17235210 |
| cross-border truck drivers in hong kong: their psychological health, sexual dysfunctions and sexual risk behaviors. | due to their job nature, cross-border truck drivers working between hong kong and china are exposed to many health risks. the aim of this study was to find out the impact of their occupation on their psychological health and sexual dysfunction and to assess their sexual risk behaviors. | 2007 | 17241250 |
| comparing the magnitude of discriminatory attitudes toward people living with hiv/aids and toward people with mental illness in the hong kong general population. | the study compared the level of discriminatory attitudes toward people living with human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) (plwha) and people with mental illness (pmi) and investigated factors associated with the absolute and relative levels of these discriminatory attitudes. an anonymous cross-sectional telephone survey interviewed 604 chinese adults aged 18-50 years from the general hong kong population. discriminatory attitudes toward both groups are prev ... | 2007 | 16849388 |
| perceptions related to human avian influenza and their associations with anticipated psychological and behavioral responses at the onset of outbreak in the hong kong chinese general population. | anticipated psychological responses and perceptions of risk have not been examined prior to the outbreak of an epidemic. | 2007 | 17276790 |
| the study of sequence configuration and functional impact of the (ac)n(at)xty motif in human beta-globin gene promoter. | in this report we examine the (ac)n(at)xty motif residing -530 bp 5' upstream of the beta-globin gene in chinese thalassaemic patients. this motif is a putative binding site for a repressor protein, termed beta protein 1 (bp1) (berg et al., nucleic acids res 1989;17:8833-8852). variations in the (ac)n(at)xty repeats affect the binding affinity of bp1, thereby altering the expression of the beta-globin gene. eight different configurations of this repeat motif are identified in our population of c ... | 2007 | 17133428 |
| pollutants in hong kong soils: polycyclic aromatic hydrocarbons. | an extensive soil survey was carried out to study the polycyclic aromatic hydrocarbon (pah) contaminations in 138 soil samples collected throughout hong kong. results demonstrated that there were low levels of pah contaminations (median of summation operator 16us epa pahs=140 microg kg(-1)) for all land uses (urban park, greening area, country park, rural area, restored landfill, agricultural farmland, orchard farm, crematorium, industrial and near highway area). however, localized hotspots were ... | 2007 | 17109918 |
| gender difference in achieving rate of maturity of the vesicoureteric junction. | our previous study on the doppler waveform of the urinary jet at the vesicoureteric junction (vuj) indicates that there is an active sphincteric mechanism in humans. we have also shown that there are immature and mature patterns of the jet, and the vuj matures around the age of 4 years. | 2007 | 17180364 |
| neurologic complications in children hospitalized with influenza: comparison between usa and hong kong. | 2007 | 17961673 | |
| theoretically estimated risk of severe acute respiratory syndrome transmission through blood transfusion during an epidemic in shenzhen, guangdong, china in 2003. | severe acute respiratory syndrome (sars) is a newly recognized infectious disease that caused an outbreak in south china in 2003. the cause of sars was identified as a novel coronavirus (cov). the existence of asymptomatic seroconvertors and the detection of the sars-cov rna in plasma during the course of infection all suggest that sars could, as least theoretically, be transmitted by transfusion. an estimate of the risk of sars transmission through blood transfusion will contribute to decisions ... | 2007 | 18036985 |
| iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | to describe the iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | 2007 | 18053285 |
| live poultry exposures, hong kong and hanoi, 2006. | since 1997, the largest epidemic of highly pathogenic avian influenza (h5n1) ever recorded has caused 172 human and several billion bird deaths. recently administered questionnaires determined that live poultry exposures have declined by approximately 63% in hong kong since 2004 and that, in vietnam, domestic backyard exposures to poultry are likely more important than retail exposures. | 2007 | 18214181 |
| chinese widowers' self-perception of growth: an exploratory study. | presence of growth after traumatic events was introduced to the academic community about a decade ago (tedeschi & calhoun, 1995). from the conventionally neglected perspective of chinese widowers, this paper reports seventeen chinese widowers' views on growth after conjugal loss. findings seem to suggest that chinese widowers would define growth as human learning, a definition probably influenced by confucian teachings. furthermore, contrary to claims made by tedeschi and calhoun (2004), it was ... | 2007 | 18928081 |
| comparison of two automated nucleic acid testing systems for simultaneous detection of human immunodeficiency virus and hepatitis c virus rna and hepatitis b virus dna. | recently developed nucleic acid testing (nat) assays incorporating simultaneous detection of human immunodeficiency virus (hiv), hepatitis c virus (hcv), and hepatitis b virus (hbv) have made hbv nat screening more feasible for blood services. this study compared the performance of two "multiplex" nat assays and their automated testing platforms. | 2007 | 17880602 |
| anticipated and current preventive behaviors in response to an anticipated human-to-human h5n1 epidemic in the hong kong chinese general population. | the prevalence of self-reported preventive behaviors in response to an anticipated local human-to-human h5n1 transmission outbreak and factors associated with such behaviors have not been examined. | 2007 | 17359545 |
| the potential impact of a prophylactic vaccine for human papillomavirus on the current cervical screening programme in hong kong. | to review and summarise current controversies in cervical screening in hong kong and discuss the potential impact of prophylactic human papillomavirus vaccination. | 2007 | 17664535 |
| evaluation of an in-house genotyping resistance test for hiv-1 drug resistance interpretation and genotyping. | the human immunodeficiency virus type 1 (hiv-1) genotyping resistance test (grt) has been considered essential for hiv-1 drug resistance monitoring. however, it is not commonly used in some developing countries in asia and africa due to its high running cost. | 2007 | 17449318 |
| spatial distribution of heavy metals in hong kong's marine sediments and their human impacts: a gis-based chemometric approach. | a geographic information system (gis)-based chemometric approach was applied to investigate the spatial distribution patterns of heavy metals in marine sediments and to identify spatial human impacts on global and local scales. twelve metals (zn, v, ni, mn, pb, cu, cd, ba, hg, fe, cr and al) were surveyed twice annually at 59 sites in hong kong from 1998 to 2004. cluster analysis classified the entire coastal area into three areas on a global scale, representing different pollution levels. backw ... | 2007 | 17624377 |
| molecular analysis of a chromosome 4 inversion segregating in a large schizophrenia kindred from hong kong. | the present study looks at a paracentric inversion on chromosome 4 [inv(4)(q13;q25)] in members of a large schizophrenia kindred from hong kong, and the possibility of a susceptibility gene for schizophrenia at one of the inversion breakpoints. fluorescence in situ hybridization with bac and fosmid clones was used to determine the location of the 4q13 and 4q25 breakpoints, however bioinformatic analysis indicated that no known genes are directly disrupted by the breakpoints. we identified severa ... | 2007 | 17644315 |
| studies on the expression of the deleted kir2ds4*003 gene product and distribution of kir2ds4 deleted and nondeleted versions in different populations. | a kir2ds4 deletion variant allele, previously identified through killer immunoglobulinlike receptor (kir) polymerase chain reaction-sequence-specific oligonucleotide probe (pcr-ssop) typing, was functionally investigated using an in vitro cell line model system and in vivo protein expression studies. the kir2ds4 deletion variant has previously been found in 80% of individuals from northern ireland, indicating that it is present at a high incidence in this population. it differs from the normal k ... | 2007 | 17321903 |
| impact of sars on avian influenza preparedness in healthcare workers. | sars was an unprecedented outbreak which brought about 1,755 infections and 302 deaths in hong kong. the similarity of sars and avian influenza prompted us to examine the relationship between sars experience and preparedness on a potential avian influenza outbreak. | 2007 | 17882357 |
| first-trimester combined screening for trisomy 21 in a predominantly chinese population. | to examine the effectiveness of first-trimester fetal trisomy 21 screening using a combination of maternal age, nuchal translucency thickness (nt) and maternal serum free beta-human chorionic gonadotropin (beta-hcg) and pregnancy-associated plasma protein-a (papp-a) levels in a predominantly chinese population in hong kong. | 2007 | 17171632 |
| deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. | mannan-binding lectin (mbl) and ficolins distinguish between self, non-self and altered-self by recognizing patterns of ligands on the surface of microorganisms or aberrant cells. when this happens mbl-associated serine protease-2 (masp-2) is activated and cleaves complement factors to start inflammatory actions. we examined human populations for masp-2 levels, masp-2 function and for the presence of mutations in coding exons of masp2. the masp-2 levels were lowest in africans from zambia (media ... | 2007 | 17252003 |
| patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis b carrier. | human papillomavirus (hpv) and hepatitis b virus (hbv) are known aetiology of cervical and hepatocellular carcinoma, respectively. both diseases share a similar clinical course, that is, the vast majority of those infected by these two viruses can eradicate the viruses spontaneously. a small sub-group who fails to clear the virus becomes chronic carrier and can progress to carcinoma many years later. we postulated that patients with pre-malignant or malignant cervical lesion are at increased ris ... | 2007 | 17550135 |
| phenotypic and population differences in the association between cilp and lumbar disc disease. | lumbar disc disease (ldd) is one of the leading causes of disability in the working-age population. a functional single-nucleotide polymorphism (snp), +1184t-->c, in exon 8 of the cartilage intermediate layer protein gene (cilp) was recently identified as a risk factor for ldd in the japanese population (odds ratio (or) 1.61, 95% ci 1.31 to 1.98), with implications for impaired transforming growth factorbeta1 signalling. | 2007 | 17220213 |
| deductive reasoning and creativity: a cross-cultural study. | the present cross-cultural study examined the relationship between deductive reasoning and creativity among college students (m age=20.4 yr., sd= .6) from hong kong (n=39) and the united states (n=38). participants performed tasks designed to measure deductive reasoning, creative writing, and insight problem-solving, all in verbal form. no correlation was found between the performance for deductive reasoning and creativity as measured by creative writing. insight problem-solving performance corr ... | 2007 | 17564227 |
| characterizing 56 complete sars-cov s-gene sequences from hong kong. | the spike glycoprotein (s) gene of the severe acute respiratory syndrome-associated coronavirus (sars-cov) has been useful in analyzing the molecular epidemiology of the 2003 sars outbreaks. | 2007 | 17112780 |
| catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from hong kong and canada. | four bacterial isolates were recovered from the blood cultures of four patients, two of whom were from hong kong and two of whom were from canada. the two hong kong strains were isolated from a 48-year-old man with intestinal obstruction and secondary sepsis (strain hku16t) and from a 39-year-old man with acute appendicitis (strain hku17), while the two canadian strains were isolated from a 74-year-old man with biliary sepsis (strain ca1) and from a 66-year-old woman with metastatic carcinoma an ... | 2007 | 17122022 |
| any effect of cyp2c9 variants on warfarin clearance in chinese patients? | 2007 | 17479200 | |
| association between hla-b*1502 allele and antiepileptic drug-induced cutaneous reactions in han chinese. | a previous study conducted in taiwan found a 100% association between hla-b*1502 allele and carbamazepine-induced stevens-johnson syndrome (sjs) in han chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). we examined this association in 24 hong kong han chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (aeds). they were matched with 48 aed-tolerant controls. hla-b*1502 was associated wi ... | 2007 | 17509004 |
| long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with bmt at first remission and hla-matched unrelated donor. | we analyzed the outcome of 108 adult acute lymphoblastic leukemia patients undergoing allogeneic bone marrow transplantation (bmt). philadelphia (ph) chromosome occurred in 35.2% patients at diagnosis. two-thirds of patients received allogeneic bmt in first complete remission (cr1) bmt. salvage bmt was performed in 21 and 16 patients at second complete remission (cr2) and beyond cr2. donors were human leukocyte antigen-identical siblings in 87 patients, and match-unrelated donors in 21 patients. ... | 2007 | 17572712 |
| association between hla-drb1 polymorphism, high-risk hpv infection and cervical neoplasia in southern chinese. | multiple determinants are involved in the progression of human papillomavirus (hpv)-infected cervical lesion to invasive cancer. human leukocyte antigen (hla) polymorphism seems to play a role. this study examined the association between hla-drb1 polymorphism, high-risk hpv infection, and the development of cervical neoplasia in southern chinese. three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade ii, 154 grade iii, and 173 invasive cancers) and 3 ... | 2007 | 17516530 |
| variants conferring risk of atrial fibrillation on chromosome 4q25. | atrial fibrillation (af) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. it affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. recent studies have provided evidence of a genetic contribution to af. mutations in potassium-channel genes have been associated with familial af but account for only a small fraction of all cases of af. we have perf ... | 2007 | 17603472 |
| emerging occupational lung infections. | recent experiences of emerging infections, such as severe acute respiratory syndrome (sars) and avian influenza (h5n1), have highlighted the risks of serious pulmonary infections from occupational exposures. occupationally acquired human immunodeficiency virus (hiv) infection could also result in life-threatening, opportunistic lung infections as a result of host immunosuppression. these three occupationally acquired infections are major public health problems that carry with them enormous econo ... | 2007 | 17609045 |
| replication and identification of novel variants at tcf7l2 associated with type 2 diabetes in hong kong chinese. | variations at a large linkage disequilibrium (ld) block of transcription factor 7-like 2 gene (tcf7l2) were reported to be associated with type 2 diabetes (t2d) in icelandic, danish and european-american populations and further replicated in other populations of european, african, and asian ancestries. however, data for chinese and comprehensive survey of the whole gene are lacking. | 2007 | 17609304 |
| agreement between breast milk dioxin levels by calux bioassay and chemical analysis in a population survey in hong kong. | chemically-activated luciferase gene expression (calux) bioassay and gas chromatography/mass spectrometry (gc/ms) are used to determine dioxin levels in food and humans. valid measures of the agreement between the two methods would improve interpretation of bioassay results. paired breast milk samples from 250 mothers, as 11 pooled samples, were analysed by gc/ms for total who-teq (7 polychlorinated dibenzo-para-dioxins, 10 polychlorinated dibenzofurans and 12 dioxin-like polychlorinated bipheny ... | 2007 | 17618674 |
| factors associated with early hospital discharge of adult influenza patients. | understanding factors affecting length of hospital stay (los) in patients with severe influenza may improve their management. | 2007 | 17668558 |
| anthropometric evaluation for primary school furniture design. | musculoskeletal symptoms are one of the top ten health problems among schoolchildren in hong kong. whether or not these symptoms are related to school furniture has yet to be determined and published data on furniture size are lacking. the purpose of the study was to determine whether the design of furniture in schools is appropriate for children's anthropometry. a total of 214 volunteer subjects were recruited. this constituted 90% of the total number of primary 5 and 6 students in the studied ... | 2007 | 17536771 |
| co-circulation of human metapneumovirus and sars-associated coronavirus during a major nosocomial sars outbreak in hong kong. | the clinico-epidemiological significance of human metapneumovirus (hmpv) detected during the sars outbreak is unknown. | 2007 | 17936066 |
| cyclic peptides from an endophytic fungus obtained from a mangrove leaf (kandelia candel). | two new cyclic depsipeptides, 1962a (1) and 1962b (2), along with the three known cyclodipeptides cyclo-(leu-tyr) (3), cyclo-(phe-gly) (4), and cyclo-(leu-leu) (5) were isolated from the fermentation broth of the mangrove endophytic fungus (no. 1962) isolated from an old leaf of kandelia candel collected in hong kong. through spectroscopic experimentation, x-ray crystallographic analysis, and acid hydrolysis followed by chiral hplc analysis, their structures were established to be 1962a, cyclo-( ... | 2007 | 17944538 |
| beliefs about cervical cancer and human papillomavirus (hpv) and acceptability of hpv vaccination among chinese women in hong kong. | to assess the knowledge and beliefs on cervical cancer and hpv infection and to evaluate the acceptability of hpv vaccination among chinese women. | 2007 | 17707077 |
| rhinovirus infection in hospitalized children in hong kong: a prospective study. | to analyze the clinical features and estimate the hospitalization disease burden of rhinovirus infection in children in hong kong. | 2007 | 17984805 |
| universal antenatal human immunodeficiency virus (hiv) testing programme is cost-effective despite a low hiv prevalence in hong kong. | to evaluate the cost-effectiveness of universal antenatal human immunodeficiency virus (hiv) testing in hong kong. | 2007 | 17548908 |
| non-typhoid salmonella mycotic aneurysm of the aortic arch. | salmonella mycotic aneurysm is a rare but potentially fatal condition. mortality is high without timely intervention. the clinical presentation is protean and early diagnosis requires a high degree of clinical alertness. prompt surgical intervention and prolonged antimicrobial therapy are keys to successful treatment. we report an 81-year-old man with an atypical presentation of salmonella mycotic aneurysm in the aortic arch. the case highlights the need to evaluate all patients over 50 years wi ... | 2007 | 17548914 |
| women's attitudes on human papillomavirus vaccination to their daughters. | this study assessed the impact of an information pamphlet on acceptance of human papillomavirus (hpv) vaccine in chinese women. the pamphlet increased the self-perceived knowledge on cervical cancer and hpv of the study subjects and had a positive influence on women accepting hpv vaccination for their daughters (p < .001). | 2007 | 17659226 |
| olanzapine-induced diabetic ketoacidosis in a chinese man. | we present a case report of a 22-year-old chinese man with schizophrenia and dissocial personality disorder who was normoglycaemic before taking olanzapine. after commencing olanzapine he developed diabetic ketoacidosis and was managed in the intensive care unit of a general hospital. olanzapine was stopped and replaced by haloperidol 5 mg/day. he was put on a strict 1500 kcal diabetic diet and required insulin injections to maintain a normal blood sugar level despite cessation of olanzapine for ... | 2007 | 17277396 |
| trace metals and organochlorines in the bamboo shark chiloscyllium plagiosum from the southern waters of hong kong, china. | the bamboo shark chiloscyllium plagiosum is an abundant benthic species along the shallow continental shelf of southeast asia. it is commonly taken by fishermen in china, india, taiwan and thailand for human consumption. this study measured trace metal and organochlorine concentrations in c. plagiosum collected from the southern waters of hong kong, china. metals (ag, cd, cr, cu, mn, ni, pb and zn) were measured in three different tissues: dorsal muscle, spleen and liver. polychlorinated bipheny ... | 2007 | 17320935 |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| a qualitative study on the comfort and fit of ladies' dress shoes. | the perceived differences between comfortable and uncomfortable shoes and the fit preferences in the different regions of ladies' shoes were explored. twenty hong kong chinese females participated in the study. each participant wore and rated the different aspects of their own comfortable and uncomfortable shoes. the wilcoxon signed rank tests showed significant differences in ten perceived characteristics between the comfortable and uncomfortable shoes. among the ten were tactile, auditory and ... | 2007 | 17353001 |
| isolation of laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in hong kong. | freshwater fish has been found to be the reservoir of laribacter hongkongensis, a recently discovered bacterium associated with community-acquired gastroenteritis. however, little is known about the ecology of this bacterium in the aquatic environment. we carried out a surveillance study to investigate the presence of l. hongkongensis in water and freshwater fish from 10 drinking water reservoirs in hong kong. | 2007 | 17714383 |
| clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in hong kong. | human bocavirus (hbov) is a recently discovered parvovirus associated with respiratory tract infections in children. we conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (npas) and fecal samples. | 2007 | 17763318 |
| tropism of avian influenza a (h5n1) in the upper and lower respiratory tract. | poor human-to-human transmission of influenza a h5n1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. we now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with h5n1 viruses in spite of an apparent lack of these receptors. | 2007 | 17206149 |
| evaluation of nuclisens easyq hiv-1 assay for quantification of hiv-1 subtypes prevalent in south-east asia. | monitoring anti-retroviral therapy requires that viral load assays for human immunodeficiency virus type 1 (hiv-1) be applicable to diverse hiv-1 subtypes. | 2007 | 17110162 |
| new evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. | our previous studies of tonsillar cancers from new south wales, australia, and jilin province in the north-east of china, provided evidence that the proportion of these cancers attributable to human papillomavirus (hpv) varies geographically. this study provides the first data on hpv in tonsillar cancers from hong kong. | 2007 | 17454751 |
| identification of molecular markers and signaling pathway in endometrial cancer in hong kong chinese women by genome-wide gene expression profiling. | endometrial cancer is the third most common gynecologic malignancy and the ninth most common malignancy for females overall in hong kong. approximately 80% or more of these cancers are endometrioid endometrial adenocarcinomas. the aim of this study was to reveal genes contributing to the development of endometrioid endometrial cancer, which may impact diagnosis, prognosis and treatment of the disease. whole-genome gene expression analysis was completed for a set of 55 microdissected sporadic end ... | 2007 | 17043662 |
| risk assessment of trace elements in the stomach contents of indo-pacific humpback dolphins and finless porpoises in hong kong waters. | the potential health risks due to inorganic substances, mainly metals, was evaluated for the two resident marine mammals in hong kong, the indo-pacific humpback dolphin (sousa chinensis) and the finless porpoise (neophocaena phocaenoides). the stomachs from the carcasses of twelve stranded dolphins and fifteen stranded porpoises were collected and the contents examined. concentrations of thirteen trace elements (ag, as, cd, co, cr, cs, cu, hg, mn, ni, se, v and zn) were determined by inductively ... | 2007 | 16979696 |
| vitamin d receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the mros study in sweden and hong kong. | the vdr is a prime candidate gene for osteoporosis. here, we studied three common vdr haplotypes in relation to bone phenotypes in 5014 participants of the global mros study. we also studied the relative expression of the haplotypes in human bone cells. one haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. | 2007 | 17371163 |
| residual levels of ddts and pahs in freshwater and marine fish from hong kong markets and their health risk assessment. | axial and ventral muscle from 10 each species of freshwater and marine fish purchased from markets in hong kong were analyzed for dichlorodiphenyltrichloroethane (total ddts including dde, ddd and ddt) and polycyclic aromatic hydrocarbons (pahs). among the 10 freshwater fish species, rice field eel (monopterus albus) showed significantly higher levels of ddts in both ventral (125 ng/g wet wt) and axial muscle (127 ng/g wet wt) than the other species. the highest concentration of pahs was detecte ... | 2007 | 16870232 |