Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| pneumocystis carinii pneumonia with oral candidiasis after infliximab therapy for crohn's disease. | 2004 | 15481319 | |
| can data from an electronic medical record identify which patients with pneumonia have pneumocystis carinii infection? | pneumocystis carinii is the leading opportunistic pulmonary infection in hiv-infected patients. invasive diagnostic procedures might be avoided if available electronic data can accurately identify patients with pneumocystis pneumonia (pcp). | 2004 | 15491925 |
| [ventilator-associated pneumonia caused by pneumocystis carinii in the non-human immunodeficiency virus infection: a report of 5 cases]. | to comprehend ventilator-associated pneumonia (vap) caused by pneumocystis carinii (p. carinii-vap) in the non-human immunodeficiency virus (hiv) infected patients. | 2004 | 15500775 |
| passive immunization of neonatal mice against pneumocystis carinii f. sp. muris enhances control of infection without stimulating inflammation. | pneumocystis carinii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised individuals. infants appear to be particularly susceptible to infection with pneumocystis. we have previously shown that there is a significant delay in clearance of the organisms from the lungs of neonatal mice compared to adults. since alveolar macrophages are the effector cells responsible for killing and clearance of pneumocystis, we have examined alveolar macrophage activity ... | 2004 | 15501746 |
| pneumocystis jiroveci (formerly pneumocystis carinii). | 2004 | 15504226 | |
| highly active anti-pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds. | trimethoprim-sulfamethoxazole and pentamidine isethionate have been used extensively for the prophylaxis and therapy of pneumonia caused by pneumocystis jirovecii. problems associated with toxicity and potential emerging resistance for both therapies necessitate the development of safe and effective analogs or new treatment strategies. in the present study, a library of 36 compounds was synthesized by using the pentamidine molecule as the parent compound modified by a 1,4-piperazinediyl moiety a ... | 2004 | 15504843 |
| assessment of clinical case-definition for hiv/aids in tanzania. | to evaluate the usefulness of world health organisation (who's) clinical case-definition (ccd) for aids in a private hospital. | 2004 | 15508335 |
| [fatal opportunistic infection following disappearance of antibodies by immunosuppressive therapy in a patient with acquired factor viii inhibitor]. | an 83-year-old man without history of the hemorrhagic diathesis was admitted to our hospital with a 4-months history of purpura and subcutaneous hematoma. he had an extraordinarily prolonged activated partial thromboplastin time, and his factor viii (f viii) activity level was 0.2%. a study revealed the existence of an igg type anti-f viii inhibitor at a titer of 1004 bethesda units/ml. he received recombinant factor viia and immunosuppressive therapy with cyclophosphamide, prednisolone and cycl ... | 2004 | 15510829 |
| concurrent granulomatous pneumocystis carinii and mycobacterium xenopi pneumonia: an unusual manifestation of hiv immune reconstitution disease. | this report of concurrent granulomatous pneumocystis carinii pneumonia (gpcp) and mycobacterium xenopi pneumonia (mxip) in a patient with advanced hiv disease 3-5 weeks after commencing antiretroviral therapy (art) fits the syndrome of hiv immune reconstitution/restoration disease (ird). it may also be a unique window into the immunology of granulomatous inflammation. | 2004 | 15516479 |
| spectrum of severe infections in an asian renal transplant population. | infections in renal transplant recipients (rtx) account for 26% of hospitalization days annually and 40% of overall mortalities. a retrospective study of infections requiring hospitalization occurring among 725 asian rtx in 2002 was performed. results: serious infections requiring at least one hospitalization occurred in 9.2% of rtx (n = 67). multiple pathogens affected 28.4% of patients, resulting in 118 infectious episodes during 93 hospitalizations. mean age of affected patients was 48 years ... | 2004 | 15518724 |
| high seroprevalence of pneumocystis infection in spanish children. | pneumocystis infection occurs worldwide, and most individuals test seropositive for pneumocystis early in childhood. little is known about the epidemiology of this infection in western europe. the seroprevalence of pneumocystis infection in 233 spanish children was determined in a community study by immunoblot analysis of sera. the overall seroprevalence was 73%, with an age-related increase from 52% at 6 years to 66% at 10 years and 80% at 13 years. the data indicated a high seroprevalence of p ... | 2004 | 15522012 |
| therapy of refractory pemphigus vulgaris with monoclonal anti-cd20 antibody (rituximab). | three patients with refractory pemphigus vulgaris improved after rituximab, an anti-cd20 monoclonal antibody directed against b cells. treatment was well tolerated immediately, but one patient developed fatal pneumocystis carinii pneumonia. serious infections have occurred in several pemphigus patients treated with rituximab and immunosuppressive medications, warranting further evaluation of risk-benefit ratio. | 2004 | 15523367 |
| interstitial pneumonitis and coinfection of human herpesvirus 6 and pneumocystis carinii in a patient with hypogammaglobulinemia. | human herpesvirus 6 (hhv-6) has occasionally been associated with cases of interstitial pneumonitis, mainly in individuals with impaired cellular immunity. here we report for the first time severe interstitial pneumonitis with simultaneous hhv-6 and pneumocystis carinii infections in the lung tissue of a young patient with hypogammaglobulinemia. | 2004 | 15528760 |
| cloning of the pneumocystis jirovecii trifunctional fas gene and complementation of its dhps activity in escherichia coli. | pneumocystis pneumonia or pcp is caused by pneumocystis jirovecii, an obligate parasite of the human lung. in this study p. jirovecii genomic sequence encoding fas, a trifunctional protein including dihydroneopterin aldolase (dhna), hydroxymethyldihydropterin pyrophosphokinase (pppk) and dihydropteroate synthase (dhps) were identified by pcr amplification from fixed broncheolar lavage samples from patients having pneumocystis pneumonia. the p. jirovecii trifunctional dhna-pppk-dhps genes (pjfas) ... | 2004 | 15531210 |
| respiratory manifestations in hiv-infected children pre- and post-haart in abidjan, the ivory coast. | among children infected with human immunodeficiency virus (hiv), respiratory diseases are a frequent cause of morbidity and mortality. this review describes respiratory manifestations of paediatric hiv infection before and after the beginning of haart in abidjan, ivory coast. in an observational cohort, hiv infected children had quarterly clinical visits and a day-clinic available all week for ill children. cd4 and viral load were measured at baseline and every 6 months thereafter. all children ... | 2004 | 15531256 |
| [mortality and survival in a cohort of 1,115 hiv-infected patients (1989-97)]. | to study survival and hiv/aids-related mortality from 1989 through 1997. to analyze the effect of antiretroviral treatment and prophylaxis against p. carinii pneumonia (pcp-prophylaxis). | 2004 | 15538901 |
| aids-defining illnesses among patients with hiv in singapore, 1985 to 2001: results from the singapore hiv observational cohort study (shocs). | the objective was to describe the causes of initial and overall aids-defining disease episodes among hiv patients in singapore. | 2004 | 15538953 |
| co-trimoxazole as prophylaxis against opportunistic infections in hiv-infected zambian children (chap): a double-blind randomised placebo-controlled trial. | no trials of co-trimoxazole (trimethoprim-sulfamethoxazole) prophylaxis for hiv-infected adults or children have been done in areas with high levels of bacterial resistance to this antibiotic. we aimed to assess the efficacy of daily co-trimoxazole in such an area. | 2004 | 15555666 |
| [pleural disease and acquired immunodeficiency syndrome]. | respiratory infections are among the most common complications in patients infected with human immune deficiency virus (hiv) and can occur at all cd4 level. pleural complications are uncommon but they have some distinctive aspects from hiv-negative patients. the ptx occurrence in hiv-positive patients was described for the first time in 1984. the total incidence of pneumothorax (ptx) in patients with acquired immune deficiency syndrome (aids) varies from 2.7% to 4.9%. the great majority occurs i ... | 2004 | 15300311 |
| late onset opportunistic infections in a renal allograft recipient: a case report. | in renal allograft recipients, infection disease complications remain an important cause of morbidity and mortality during the post-transplant period. this complication occurs more frequently from 1 to 6 months after transplant. the epidemiology of infection during the postoperative period is less well characterized, because recipients routinely reside at home. we describe a case of late onset candida albicans and hsv-1 esophagitis, and pneumocystis carinii pneumonia, that occurs 9 years after r ... | 2004 | 15316301 |
| imaging of unusual diffuse lung diseases. | computed tomography scans are commonly used in imaging lung diseases. as more information accumulates, patterns of rare or new diseases on ct scans are being increasingly reported. several pulmonary diseases have distinguishing features, which are better delineated on high resolution ct scans than plain chest radiographs. the radiographic features of unusual diffuse lung diseases published in the past two years are described. | 2004 | 15316437 |
| severe combined immunodeficiency syndrome associated with colonic stenosis. | this is the first report in mexico of a case of severe combined immunodeficiency syndrome (scid) associated with colonic stenosis. the patient was an 8-month-old mexican female who died at this age. she suffered infections due to microorganisms such as mycobacterium tuberculosis, bacille calmette-guérin (bcg), candida sp., and pneumocystis carinii; and had frequent diarrhea. she was hiv-negative without familial history of immunodeficiency. the aim of the work was to analyze the immunologic stat ... | 2004 | 15325511 |
| pneumocystis carinii infection. update and review. | to review and update the literature on current trends with regard to pneumocystis carinii (jiroveci ) diagnosis, treatment modalities, and its role in human disease processes. | 2004 | 15335253 |
| cases from the osler medical service at johns hopkins university. diagnosis: p. carinii pneumonia and primary pulmonary sporotrichosis. | presenting features: a 53-year-old man who had human immunodeficiency virus (hiv) presented to the johns hopkins hospital with a 3-month history of increasing dysphagia, cough, dyspnea, chest pain, and an episode of syncope. his past medical history was notable for oral and presumptive esophageal candidiasis that was treated with fluconazole 6 months prior to presentation. three months prior to presentation, he discontinued his medications, and his symptoms of dysphagia recurred. during that tim ... | 2004 | 15336585 |
| pcr diagnosis of pneumocystis carinii on sputum and bronchoalveolar lavage samples in immuno-compromised patients. | the polymerase chain reaction (pcr) technique was compared with wright-giemsa (wg), gomori methenamine silver (gms) stains and an immunofluorescence assay (ifa) for detection of pneumocystis carinii in immuno-compromised patients. specimens of 21 bronchoalveolar lavages (bal) and 139 sputum samples, were obtained from 157 patients (38 with aids and 119 with hiv) from four hospitals in khon kaen, thailand. a true positive required at least two positives by techniques considered gold standard test ... | 2004 | 15340838 |
| novel bisbenzamidines as potential drug candidates for the treatment of pneumocystis carinii pneumonia. | a series of pentamidine congeners has been synthesized and screened for their in vitro activity against pneumocystis carinii. among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study. | 2004 | 15357989 |
| pneumocystis carinii pneumonia in a patient without a predisposing illness: case report and review. | a case of pneumocystis carinii pneumonia in a patient without an underlying immunosuppressing condition is reported, and 12 other previously reported cases are reviewed. when compared with pneumocystis carinii pneumonia in association with aids and in other immunosuppressing conditions, pneumocystis carinii pneumonia in patients without predisposing conditions resembles more closely that seen in immunosuppressing conditions other than aids. | 2004 | 15370678 |
| the fungal dna examination is useful as a sensitive parameter for the initiation and the quit of antifungal therapy in immunocompromised pediatric patients after surgery. | the purpose of this study is whether the fungal deoxyribonucleic acid (dna) examination is useful as a sensitive parameter for pediatric surgical patients with mycosis. the eleven episodes of five cases (4 cases; progressive liver disease after biliary atresia operation, 1 case; short bowel syndrome and long term total parenteral nutrition with megacystis microcolon intestinal hypoperistalsis syndrome) with mycosis were divided into two groups according to the difference of therapeutic protocols ... | 2004 | 15373229 |
| unique biosynthesis of dehydroquinic acid? | a search of the genomic sequences of the thermophilic microorganisms aquifex aeolicus, archaeoglobus fulgidus, methanobacterium thermoautotrophicum, and methanococcus jannaschii for the first seven enzymes (arog, b, d, e, k, a, and c ) involved in the shikimic acid biosynthetic pathway reveal two key enzymes are missing. the first enzyme in the pathway, 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthase (arog) and the second enzyme in the pathway, 5-dehydroquinic acid synthase (arob) are " ... | 2004 | 15381397 |
| enhanced lung injury and delayed clearance of pneumocystis carinii in surfactant protein a-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species. | surfactant protein a (sp-a), a member of the collectin family, selectively binds to pneumocystis carinii and mediates interactions between pathogen and host alveolar macrophages in vitro. to test the hypothesis that mice lacking sp-a have delayed clearance of pneumocystis organisms and enhanced lung injury, wild-type c57bl/6 (wt) and sp-a-deficient mice (sp-a(-/-)) with or without selective cd4(+)-t-cell depletion were intratracheally inoculated with pneumocystis organisms. four weeks later, cd4 ... | 2004 | 15385504 |
| iron chelator daphnetin against pneumocystis carinii in vitro. | although there are several drugs and drug combinations for the treatment of pneumocystis carinii (p. carinii) pneumonia, all drugs have the toxicity as well as low efficacy. iron chelators have been proposed as a source of new drugs for combating these infections. we hypothesized that iron chelators would suppress the growth of p. carinii by deprivation of the nutritional iron required for growth. in this study, a short-term axenic culture system of p. carinii was established. daphnetin (7,8-dih ... | 2004 | 15569490 |
| [utility of bronchoalveolar lavage in immunocompromised children: diagnostic yield and complications]. | immunocompromised children are at high risk for developing pneumonia due to opportunistic pathogens. the role of bronchoalveolar lavage (bal) in the evaluation of such patients is still controversial. | 2004 | 15574271 |
| fatal pneumocystis pneumonia with good syndrome and pure red cell aplasia. | 2004 | 15578389 | |
| pneumocystis carinii pneumonia in patients with ulcerative colitis. | 2004 | 15580408 | |
| [diagnosis and therapy of pneumocystosis complicated after renal transplantation]. | to investigate the early diagnosis, treatment and prevention of pneumocystosis complicated after renal transplantation. | 2004 | 15587162 |
| detection of pneumocystis carinii f. sp. hominis and viruses in presumably immunocompetent infants who died in the hospital or in the community. | fresh-frozen lung and tracheal-aspirate specimens obtained from 112 infants who died in santiago, chile, during 1998-2000 were analyzed for the presence of pneumocystis dna, by use of nested dna amplification of the large subunit mitochondrial rrna, and for the presence of viruses, by use of culture and immunofluorescence. pneumocystis dna was detected in specimens from 45 (51.7%) of 87 infants who died in the community and from 5 (20%) of 25 infants who died in the hospital (p=.006). primary in ... | 2004 | 15593013 |
| three-dimensional quantitative structure-activity and structure-selectivity relationships of dihydrofolate reductase inhibitors. | three-dimensional quantitative structure-activity relationship (3d-qsar) modelling using comparative molecular similarity indices analysis (comsia) was applied to a series of 406 structurally diverse dihydrofolate reductase (dhfr) inhibitors from pneumocystis carinii (pc) and rat liver (rl). x-ray crystal structures of three inhibitors bound to pcdhfr were used for defining the alignment rule. for pcdhfr, a qsar model containing 6 components was selected using leave-10%-out cross-validation (n= ... | 2004 | 15595459 |
| hyper-igm syndrome: report of one case. | the hyper-igm syndrome (him) is a rare primary immunodeficiency disorder caused by defects in the cd40 ligand (cd40l)/cd40-signaling pathway. it is characterized by recurrent infections with markedly decreased igg, iga and ige levels but normal or elevated serum igm levels. a 5-month-old boy presented with rapidly progressive pneumonia which responded poorly to antibiotics. high levels of igm and very low levels of igg, ige and iga were noted in his plasma specimen (igm, 128 mg/dl; igg, 18 mg/dl ... | 2004 | 15868849 |
| [pneumocystis carinii--diagnosis based on dna amplification technique]. | pneumocystis carinii f. sp. hominis is an important cause morbidity and morality, causing p. carinii pneumonia (pcp) in aids and other immunocompromised patients. long thought of as protozoan, molecular analysis of the ribosomal gene locus first demonstrated that p. carinii is a member of the fungal kingdom. currently p. carinii is considered to be fungus likely to ascomycetes, based on its ultrastructure, certain elements of its cellular biology, and nucleotide sequences of main genetic loci. t ... | 2004 | 15754651 |
| [new aspects of epidemiology and treatment of pneumocystis carinii infection]. | pneumocystis carinii is an opportunistic eukaryotic pathogen most common causing pneumonia in immunocompromised host. dna p. carinii f. sp. hominis has been frequently detected in air samples collected from environments of p. carinii pneumonia (pcp) patients and nasal swabs samples from contact health care workers and family. epidemiological studies suggested not-only the possibility of person-to-person infection transmission. first hypothesis of reactivation latent infection of the causing the ... | 2004 | 15754652 |
| [the experimental study of garlicin in treating pneumocystis carinii pneumonia in rats]. | to assess the therapeutic effect of garlicin on pneumocystis carinii pneumonia (pcp) of immunosuppressed rats. | 2004 | 15830863 |
| pneumocystis pneumonia: an update. | pneumocystis pneumonia is a major cause of illness and death in immunocompromised hosts. the numbers of pneumocystis pneumonia cases in thailand have increased each year from 1992 to 2000 and peaked in 2000 at 6,255 cases. the microbe that causes pneumocystis pneumonia in humans is called pneumocystis jirovecii. pneumocystis sp. was discovered nearly a century ago, but the knowledge of pneumocystis sp. remained poorly understood, until the molecular biology techniques help scientists verify it f ... | 2004 | 16083208 |
| pneumocystis carinii pneumonia after renal transplantation. | being immuno-suppressed, renal allograft recipients are at increased risk of contracting various infectious complications. pneumocystis carinii pneumonia (pcp) is one of the important opportunistic infection causing high morbidity and mortality in these patients. majority of studies has reported the occurrence of pcp during 6 months to one year after renal transplantation. this communication describes occurrence of pcp in five renal allograft recipients 10 weeks to 72 months after transplantatio ... | 2004 | 16295369 |
| presentation of dapsone-induced methemoglobinemia in a patient status post small bowel transplant. | methemoglobinemia, an uncommon hemoglobinopathy, affects oxygen transport, causing tissue hypoxia. in the perioperative period, methemoglobinemia is often overlooked as a cause of low oxygen saturation, often mistaken for the more common causes of hypoxia, such as atelectasis, pulmonary edema, or pulmonary embolus, among other causes of respiratory failure. most cases of methemoglobinemia in the perioperative period are precipitated by local anesthetics, especially benzocaine. dapsone, a sulfone ... | 2005 | 16297761 |
| the acronym "pcp" is pneumocystis pneumonia, not pneumocystis carinii pneumonia. | 2005 | 16304030 | |
| survey of zoonoses recorded in scotland between 1993 and 2002. | all the human and animal laboratory reports of zoonoses sent to health protection scotland between 1993 and 2002 were identified. there were 24,946 reports from veterinary laboratories, and 94,718 (20 per cent) of the 468,214 reports from medical laboratories were considered to be zoonotic. the most common reports of zoonoses from people were campylobacter, salmonella, cryptosporidium and giardia species and escherichia coli o157. the most common reports of zoonoses from animals were salmonella, ... | 2005 | 16311383 |
| steroid-induced tumor lysis syndrome in a patient with mycosis fungoides treated for presumed pneumocystis carinii pneumonia. | 2005 | 16315260 | |
| eye signs that alert the clinician to a diagnosis of aids. | one of the hallmarks of progressive immune deficiency is a steady decline in the absolute number of cd4+ t-lymphocytes. as the immune response thus becomes suppressed, opportunistic systemic infections such as protozoal (pneumocystis carinii pneumonia, disseminated toxoplasmosis), viral (cytomegalovirus pneumonitis and colitis and persistent invasive herpes simplex lesions), fungal (cryptococcossis and esophageal candidiasis) and bacterial infections (atypical mycobacterial and extrapulmonary tu ... | 2005 | 16320530 |
| cell-mediated adaptive immune defense of the lungs. | cell-mediated adaptive immune responses contribute to defense against all classes of pulmonary pathogens and are essential against viruses, mycobacteria, and fungi, including pneumocystis carinii. adaptive responses depend on sequential pairwise interactions between three cell types: t cells, natural killer (nk) cells, and dendritic cells (dc). differential expression of specific adhesion molecules and chemokines regulates the location and timing of these interactions. primary adaptive responses ... | 2005 | 16322591 |
| ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of pneumocystis spp.: differential sensitivities to atovaquone. | the lung pathogen pneumocystis spp. is the causative agent of a type of pneumonia that can be fatal in people with defective immune systems, such as aids patients. atovaquone, an analog of ubiquinone (coenzyme q [coq]), inhibits mitochondrial electron transport and is effective in clearing mild to moderate cases of the infection. purified rat-derived intact pneumocystis carinii cells synthesize de novo four coq homologs, coq7, coq8, coq9, and coq10, as demonstrated by the incorporation of radiol ... | 2005 | 16087753 |
| acute interstitial pneumonitis during chemotherapy for haematological malignancy. | fourteen adult patients with haematological malignancies (eight non-hodgkin's lymphoma, one multiple myeloma, one chronic lymphocytic leukaemia, two acute lymphoblastic leukaemia and two acute myeloid leukaemia) developed acute interstitial pneumonitis (ip) during the course of chemotherapy. all patients manifested high fever over 38 degrees c, bilateral diffuse pulmonary interstitial infiltrates in the chest radiograph and severe hypoxia without hypercapnia in the arterial blood gas analysis. p ... | 2005 | 16098118 |
| vitamin b3 confers resistance to sulfa drugs in saccharomyces cerevisiae. | sulfa drugs are ubiquitous antibiotics used to treat bacterial infections and diseases caused by eukaryotes, such as pneumocystis carinii, the leading cause of pneumonia (pcp) in hiv patients. a daily regimen of sulfonamides and multivitamins including vitamin b3 is also recommended for persons with hiv. we show that exogenous vitamin b3 (nicotinate) confers resistance to sulfa drugs in saccharomyces cerevisiae, a model for p. carinii. we propose a model of metabolic rerouting in which increased ... | 2005 | 16112818 |
| [management of septic shock and acquired respiratory distress syndrome in pediatric cancer patients]. | septic shock occurs in 6 % of paediatric cancer patients with neutropenia and fever. the mortality of the septic shock is 40 % in bmt patients and 5 % in others. one third of paediatric ards cases affect immunocompromised individuals with a total mortality of 45 % and 80 % after bmt. septic shock is caused by gram-negative bacteria in more than 75 %. ards is due to pneumonia in more than 50 %, sepsis in about 25 %. this article provides the recommendations of the infectious diseases working part ... | 2005 | 16288359 |
| pneumocystis carinii: has the name really been changed? | the proposed renaming of pneumocystis carinii has caused much confusion and controversy among authors, peer reviewers, editors, and interested readers. proponents of the new nomenclature emphasize the fact that the new names are judged to be "valid" by the international code of botanical nomenclature. what is generally not appreciated is the fact that the international code of botanical nomenclature does not make any determination as to the scientific correctness of proposed names; rather, it ma ... | 2005 | 16288399 |
| has the name really been changed? it has for most researchers. | 2005 | 16288400 | |
| non-specific interstitial pneumonia in an hiv positive patient. | a 56 year old male presented with features of interstitial lung disease and was detected hiv positive. histopathology of the lung suggested non-specific interstitial pneumonia with no evidence of tumour or pneumocystis carinii. the patient responded to steroids and was started on anti-retroviral treatment. | 2005 | 16121814 |
| pneumocystis carinii pneumonia in hiv infected patients from mumbai. | pneumocystis carinii pneumonia (pcp) is believed to be rare in the developing world and no large prospective indian series have been reported to date. the present study was conducted to study the clinical profile and outcome of pcp in patients with hiv infection. | 2005 | 16124351 |
| duplication of peri-kappab and nf-kappab sites of the first human immunodeficiency virus type 2 (hiv-2) transmission in brazil. | after the identification of hiv-2 in 1986, most of the cases reported have been concentrated in west africa. we identified a case of hiv-2 infection in são paulo, brazil of a 45-year-old female who presented with pneumocystis carinii pneumonia, with a cd4 count of 22 cells/ml. dna samples from this patient were subjected to end-point pcr amplification of the ltr region. clones were sequenced and subjected to phylogenetic analyses. all clones were subtype a related, and four presented an insertio ... | 2005 | 16386115 |
| respiratory pathogens in bronchoalveolar lavage in a puerto rican population infected with the human immunodeficiency virus. | to describe the respiratory pathogens found in the bronchoalveolar lavage of a puerto rican population infected with the human immunodeficiency virus (hiv). | 2005 | 16331860 |
| characterization of nebulized buparvaquone nanosuspensions--effect of nebulization technology. | the poorly soluble drug buparvaquone is proposed as an alternative treatment of pneumocystis carinii pneumonia (pcp) lung infections. physically stable nanosuspensions were formulated in order to deliver the drug at the site of infection using nebulization. the aerosolization characteristics of two buparvaquone nanosuspensions were determined with commercial jet and ultrasonic nebulizer devices. aerosol droplet size distribution was determined with laser diffractometry (ld). nebulization of the ... | 2005 | 16332575 |
| [a study of initial antiretroviral therapy effectiveness, survival and safety in hiv+ patients]. | to study initial antiretroviral therapies indicated for hiv-infected patients during the 2001-2003 period regarding effectiveness, survival and safety. | 2005 | 16351454 |
| international neuroaids: prospects of hiv-1 associated neurological complications. | neurological complications associated with hiv-1/aids are being recognized with a high frequency that parallels the increased number of aids cases. the early infiltration by hiv-1 into the nervous system can cause primary and/or secondary neurological complications. the most common neurocognitive disorder is aids dementia complex (adc). in developing countries of asia the three most opportunistic infections are tuberculosis (tb), cryptococcosis, and pneumocystis carinii pneumonia. therefore, it ... | 2005 | 16354575 |
| recurrent corneal erosion (rce) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (aids). | we present a case of an acquired immune deficiency syndrome (aids) patient with recurrent erosion (rce) secondary to lattice corneal dystrophy. as a human immunodeficiency virus (hiv)-infected patient becomes more immunocompromised, the ocular surface defense mechanisms may be compromised. lattice dystrophy, rce, and modifying approaches to the management of rce in an hiv-positive or aids patient are reviewed. | 2005 | 16361033 |
| interstitial lung disease and xerostomia as initial manifestations in a patient with human immunodeficiency virus infection. | a 56-year-old human immunodeficiency virus (hiv)-infected man presented with progressive interstitial lung disease (ild) and lymphocyte infiltration of the salivary glands which mimicked autoimmune disease. pneumonia, which was very likely caused by pneumocystis carinii, developed after 3 courses of monthly methylprednisolone pulse therapy for ild. both enzyme immunoassay and western blot analysis confirmed the hiv infection. after antibiotic treatment, the pneumonia gradually resolved. autoimmu ... | 2005 | 15843861 |
| pneumocystis carinii activates the nf-kappab signaling pathway in alveolar epithelial cells. | pneumocystis carinii pneumonia (pcp) is a clinically important infection of immunocompromised patients. although the interaction of pneumocystis with the alveolar epithelium has been well documented, very little information regarding the epithelial response to pneumocystis is currently available. in order to study pneumocystis-epithelium interactions, a murine cell line derived specifically from an alveolar epithelial cell (aec) was utilized. the coculture of murine aecs with mouse pneumocystis ... | 2005 | 15845480 |
| pneumocystis carinii pneumonia infection in a patient with known chronic mucocutaneous candidiasis. | chronic mucocutaneous candidiasis is a disorder of the skin, nails or mucous membranes in the absence of another cause of the infection. it is also associated with autoimmune endocrinopathies in 40% of patients. it is thought to be due to a t-cell defect, although no precise mechanism has been elucidated. there have been two previous cases of pneumocystis carinii pneumonia reported with this condition. we report a fatal case in a 34-year-old male. | 2005 | 15955158 |
| estimated economic losses of hospitalized aids patients at siriraj hospital from january 2003 to december 2003: time for aggressive voluntary counseling and hiv testing. | this retrospective study was performed to explore the pattern of adult hiv-infected patients admitted to siriraj hospital from january 2003 to december 2003 and estimated the economic losses of these patients. two hundred and forty four medical records were available for review. the proportion of male to female was 2 to 1. mean age of patients was 36.64 +/- 9.72 years. the mean cd4 count among 112 patients was 82.79 +/- 96.49 cell/mm3. one hundred and twenty four (50.82%) were newly diagnosed of ... | 2005 | 15962640 |
| gene arrays at pneumocystis carinii telomeres. | in the fungus pneumocystis carinii, at least three gene families (prt1, msr, and msg) have the potential to generate high-frequency antigenic variation, which is likely to be a strategy by which this parasitic fungus is able to prolong its survival in the rat lung. members of these gene families are clustered at chromosome termini, a location that fosters recombination, which has been implicated in selective expression of msg genes. to gain insight into the architecture, evolution, and regulatio ... | 2005 | 15965256 |
| [pneumocystis pneumonia (pcp)--pneumocystis carinii pneumonia (syn. pneumocystis jirovecii pneumonia)]. | 2005 | 15973609 | |
| design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain. | as part of a search for dihydrofolate reductase (dhfr) inhibitors combining the high potency of piritrexim (ptx) with the high antiparasitic vs mammalian selectivity of trimethoprim (tmp), the heretofore undescribed 2,4-diamino-6-(2',5'-disubstituted benzyl)pyrido[2,3-d]pyrimidines 6-14 with o-(omega-carboxyalkyl) or omega-carboxy-1-alkynyl groups on the benzyl moiety were synthesized and tested against pneumocystis carinii, toxoplasma gondii, and mycobacterium avium dhfr vs rat dhfr. three n-(2 ... | 2005 | 15974594 |
| [serological diagnosis of pneumocystosis in the population of the republic of armenia]. | serological investigations were first conducted in apparently healthy children and adults for pneumocyctosis in the republic of armenia in 2001-2004. the investigations provided evidence for that some of them were found to have antibodies to pneumocystis carinii, which is indicative of the circulation of the pathogen of p. carinii infection among the population of armenia. there were high serological affliction rates of p. carinii among the population in the republic of armenia, which shows it n ... | 2005 | 15984614 |
| is pneumocystis carinii pneumonia after stem cell transplantations a contagious disease? | we report of twins who underwent hematopoietic stem cell transplantation (hsct) for neonatal acute leukemia. hospitalized in the same room from the time the first one demonstrated respiratory symptoms, they both developed pneumocystis jiroveci (formerly carinii) pneumonia (pcp) 2 wk apart. this observation suggests that pcp may be a contagious disease in hsct recipients. this may be especially true for infants and young children who are at risk of primary p. jiroveci infection, and should be avo ... | 2005 | 15877810 |
| inhibition of surfactant activity by pneumocystis carinii organisms and components in vitro. | this study examines the direct inhibitory effects of pneumocystis carinii (pc) organisms and chemical components on the surface activity and composition of whole calf lung surfactant (wls) and calf lung surfactant extract (clse) in vitro. incubation of wls suspensions with intact pc organisms (10(7) per milligram of surfactant phospholipid) did not significantly alter total phospholipid levels or surfactant protein a content. incubation with intact pc organisms also did not impair dynamic surfac ... | 2005 | 15886399 |
| successful treatment of cmv ventriculitis immune reconstitution syndrome. | 2005 | 15897524 | |
| 5' transcript replacement in vitro catalyzed by a group i intron-derived ribozyme. | group i intron-derived ribozymes can perform a variety of catalytic reactions, including the replacement of the 3' end of a mutant rna transcript with a corrected version of the transcript [sullenger, b. a., and cech, t. r. (1994) nature 371, 619-622]. we now demonstrate in vitro that a ribozyme, derived from a pneumocystis carinii group i intron, can replace the 5' end of a targeted exogenous rna with an endogenous rna. our model system is a short synthetic mimic of a k-ras transcript, in which ... | 2005 | 15909994 |
| re-examination of inhibitor resistance conferred by qo-site mutations in cytochrome b using yeast as a model system. | cytochrome b from yeast (saccharomyces cerevisiae meyer ex hansen) provides a convenient model system for the study of qo-site inhibitor (qoi) resistance mutations from a variety of organisms. qoi resistance mutations from fungal plant pathogens (g143a and f129l), malaria agent plasmodium sp (y279c/s), and pneumocystis carinii (l275f), an opportunistic pathogenic fungus of man, were introduced into yeast cytochrome b and their effect on the binding of a variety of natural (myxothiazol and stigma ... | 2005 | 15912560 |
| lung transplantation for cystic fibrosis: 6-year follow-up. | lung transplantation is currently the most effective means of improving survival and quality of life in patients with end-stage cystic fibrosis. in reviewing our 6-year experience we sought to evaluate complications and survival after sequential bilateral lung transplantation. between october 1996 and october 2002, 114 patients with cystic fibrosis were referred to us from 15 italian regional centers and 2 support centers for cystic fibrosis as possible candidates for lung transplantation. of th ... | 2005 | 15914093 |
| increased risk of pneumocystis carinii and community-acquired pneumonia with tobacco use in hiv disease. | tobacco smoking-related diseases continue to be of great health concern for the public, in general, and may be particularly deleterious for immunosuppressed hiv-positive individuals, who exhibit widespread tobacco use. | 2005 | 15916913 |
| the findings of surgical lung biopsy in hiv patients in the era of highly active antiretroviral therapy. | surgical lung biopsy (slb) is rarely necessary in the evaluation of pulmonary infiltrates in patients with human immunodeficiency virus (hiv). the aim of this study is to describe the findings of slb in a recent cohort of hiv-infected patients with unexplained pulmonary infiltrates, and determine the impact of this procedure on management and outcome of these patients. | 2005 | 15919273 |
| adjuvant chemoradiation using 5-fluorouracil/folinic acid/cisplatin with or without paclitaxel and radiation in patients with completely resected high-risk gastric cancer: two cooperative phase ii studies of the aio/aro/aco. | the current two studies evaluate the feasibility, toxicity and efficacy of an adjuvant combined modality treatment strategy containing a three to four-drug chemotherapy regimen plus 5-fluorouracil (fu)-based radiochemotherapy. | 2005 | 15919686 |
| necrotizing vasculopathy of the cns: case report. | a 62-year-old man with progressive cerebellar and brainstem dysfunction had gadolinium-enhancing lesions in basal ganglia and occipital lobe on mri suggestive of primary cns lymphoma (pcnsl). the patient, who had been treated with high-dose steroid hormones for several months, developed respiratory failure and expired before a histological diagnosis could be obtained. the postmortem examination showed pneumocystis cariniiwas the cause of death. pathology of the brain showed a necrotizing vasculo ... | 2005 | 15926001 |
| immunosuppression and infectious complications in patients with stage iv indolent lymphoma treated with a fludarabine, mitoxantrone, and dexamethasone regimen. | myelosuppression and immunosuppression occur with purine analogs. the objective of the current study was to investigate the effects of combined fludarabine, mitoxantrone, and dexamethasone (fnd) followed by interferon/dexamethasone on myelosuppression (absolute neutrophil counts), immunosuppression (cd4 and cd8 counts), and infectious complications in patients with previously untreated, stage iv indolent lymphoma. | 2005 | 15948158 |
| pulmonary complications in adult blood and marrow transplant recipients: autopsy findings. | to describe the pulmonary findings at autopsy of blood and bone marrow transplant (bmt) recipients. | 2005 | 16162733 |
| fdg-pet imaging in pneumocystis carinii pneumonia. | the authors present a case of a 26-year-old man, under investigation for cushing syndrome, who presented acutely with a dry cough and fever. the blood tests were unremarkable apart from a moderate to severe leukopenia. imaging tests were suggestive of an atypical pneumonia, which was proven to be pneumocystis carinii pneumonia (pcp) on cytology examination of a bronchoalveolar lavage (bal). the acute lung changes were demonstrated on a whole-body f-18 fluorodeoxyglucose (fdg) positron emission t ... | 2005 | 16166846 |
| (1-->3)-beta-d glucan is a diagnostic and negative prognostic marker for pneumocystis carinii pneumonia in patients with connective tissue disease. | to assess risk factors for p. carinii pneumonia (pcp) and compare the outcome of survivors and nonsurvivors in patients with various connective tissue diseases (ctd). | 2005 | 16173245 |
| food and drug administration drug approval summary: temozolomide plus radiation therapy for the treatment of newly diagnosed glioblastoma multiforme. | on march 15, 2005, the u.s. food and drug administration approved temozolomide (temodar capsules, schering-plough research institute) for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment. five hundred seventy-three glioblastoma multiforme patients were randomized to receive either temozolomide + radiotherapy (n = 287) or radiotherapy alone (n = 286). patients in the temozolomide + radiotherapy arm recei ... | 2005 | 16203762 |
| a prospective, non-randomised phase 1-2 trial of vacop-b with filgrastim support for hiv-related non-hodgkin's lymphoma. | non-hodgkin's lymphoma (nhl) remains an important complication of associated hiv infection despite advances in antiretroviral therapy (art), and the optimum chemotherapy regimen for this disease remains to be defined. a dose-escalation trial was performed to determine the maximum tolerated doses of etoposide and doxorubicin as part of the 12-week vacop-b regimen, supported by filgrastim (r-methug-csf). patients with aggressive histology hiv-related nhl who were previously untreated with chemothe ... | 2005 | 16216784 |
| pneumocystis carinii pneumonia on f-18 fdg pet. | 2005 | 16237310 | |
| immunodeficiency in the absence of high viral load in pig-tailed macaques infected with simian immunodeficiency virus sivsun or sivlhoest. | simian immunodeficiency virus (siv) is known to result in an asymptomatic infection of its natural african monkey host. however, some siv strains are capable of inducing aids-like symptoms and death upon experimental infection of asian macaques. to further investigate the virulence of natural siv isolates from african monkeys, pig-tailed (pt) macaques were inoculated intravenously with either of two recently discovered novel lentiviruses, sivlhoest and sivsun. both viruses were apparently apatho ... | 2005 | 16254339 |
| human pneumocystosis. | pneumocystis is an atypical fungus causing pneumonia in immuno-compromised individuals. though previously termed as pneumocystis carinii, the recent taxonomy has considered human derived pneumocystis to be a different species pneumocystis jiroveci. the organism is the most common cause of opportunistic infections among patients with acquired immunodeficiency syndrome (aids) in developed countries. incidence of pneumocystis pneumonia or pneumocystosis in developing countries including india conti ... | 2005 | 16255399 |
| hospitalizations for metabolic conditions, opportunistic infections, and injection drug use among hiv patients: trends between 1996 and 2000 in 12 states. | rapid changes in hiv epidemiology and highly active antiretroviral therapy (haart) may have resulted in recent changes in patterns of inpatient utilization. | 2005 | 16284539 |
| [opportunistic protozoa--the problem in immunodeficient patients]. | protozoan infections with a mild or asymptomatic course in immunocompetent individuals, in the case of immunocompromised patients could cause severe syndromes or fatal outcome. the different clinical course is possible to diagnose only with specific laboratory methods. actual settlements on the most often diagnosed in human opportunistic protozoan infections pathogenesis and diagnostics are presented. | 2005 | 15997648 |
| de novo mutation causing x-linked hyper-igm syndrome: a family study in taiwan. | x-linked hyper-igm syndrome (xhim) is a rare primary immunodeficiency disorder caused by mutations of the gene encoding the cd40 ligand (cd40l). it is characterized by recurrent infections with markedly decreased serum igg, iga and ige levels but normal or elevated igm levels. we report the clinical manifestations and complete immune studies in the first family with molecularly proven xhim in taiwan. a 5-month-old boy presented with rapidly progressive pneumonia which responded poorly to antibio ... | 2005 | 15997875 |
| a murine model of dual infection with cytomegalovirus and pneumocystis carinii: effects of virus-induced immunomodulation on disease progression. | despite the use of antimicrobial prophylaxis, cytomegalovirus (cmv) and pneumocystis carinii (pc) pneumonia (pcp) are both leading causes of morbidity and mortality in immunocompromised patients. it has previously been reported that cmv infection modulates host immune responses with a variety of mechanisms which include the suppression of helper t cell functions and antigen presenting cell (apc) functions, both of which are critical for pcp resolution. however, the mechanisms of these interactio ... | 2005 | 16002171 |
| mycophenolate mofetil may protect against pneumocystis carinii pneumonia in renal transplanted patients. | pneumocystis carinii pneumonia (pcp) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (tms). mycophenolate mofetil (mmf) has been shown to have a strong protective effect against pcp in rats. this effect is also suggested in humans by the absence of pcp in patients receiving mmf. after january 1998 mmf has been used with no tms prophylaxis in renal transplanted patients. in azathioprine (aza) treated patients tms prophylaxis was maintained. the incidence ... | 2005 | 16021287 |
| primary brain tumors treated with steroids and radiotherapy: low cd4 counts and risk of infection. | patients with primary brain tumors are often treated with high doses of corticosteroids for prolonged periods to reduce intracranial swelling and alleviate symptoms such as headaches. this treatment may lead to immunosuppression, placing the patient at risk of life-threatening opportunistic infections, such as pneumocystis carinii pneumonia. the risk of contracting some types of infection may be reduced with prophylactic antibiotics. the purpose of this study was to determine the occurrence of l ... | 2005 | 16029802 |
| [detection of pneumocystis carinii dna in rats by pcr-elisa]. | to establish a pcr-elisa and evaluate its use in detecting dna of pneumocystis carinii (p. c) in rat model. | 2005 | 16042208 |
| lipophilic antifolate trimetrexate is a potent inhibitor of trypanosoma cruzi: prospect for chemotherapy of chagas' disease. | trypanosoma cruzi, a protozoan parasite, is the causative agent for chagas' disease, which poses serious public health problem in latin america. the two drugs available for the treatment of this disease are effective only against recent infections and are toxic. dihydrofolate reductase (dhfr) has a proven track record as a drug target. the lipophilic antifolate trimetrexate (tmq), which is an fda-approved drug for the treatment of pneumocystis carinii infection in aids patients, is a potent inhi ... | 2005 | 16048931 |
| trans insertion-splicing: ribozyme-catalyzed insertion of targeted sequences into rnas. | a group i intron-derived ribozyme from pneumocystis carinii has been previously shown to bind an exogenous rna substrate, splice out an internal segment, and then ligate the two ends back together (the trans excision-splicing reaction). we demonstrate that this same ribozyme can perform a trans insertion-splicing (tis) reaction, where the ribozyme binds two exogenous rna substrates and inserts one directly into the other. reactions were optimized for both yield and rate, with optimum reactions c ... | 2005 | 16060679 |
| hiv-associated retinopathy in the haart era. | the effectiveness of highly active antiretroviral therapy (haart) in restoring immune function in patients with acquired immunodeficiency syndrome (aids) has led to changes in the incidence, natural history, management, and sequelae of human immunodeficiency virus (hiv)-associated retinopathies, especially cytomegalovirus (cmv) retinitis. | 2005 | 16077362 |