Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients. | background: human herpesvirus 6 (hhv-6) and epstein-barr virus (ebv) have been repeatedly associated with multiple sclerosis (ms) pathogenesis. also, it has been speculated that, besides its immunomodulatory properties, the efficacy of interferon beta (ifn-beta) in treating the disease may be related to its antiviral properties. the objectives of this study were to evaluate the in vivo antiviral effect of ifn-beta-1b over hhv-6 and ebv and to analyze whether such effect could be involved in its ... | 2011 | 21518144 |
| pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica: comparison of lesional t-cell subsets and investigation of viral associations. | background: pityriasis lichenoides (pl) exhibits a broad clinical spectrum that includes both acute and chronic forms. the precise biologic mechanisms underlying pl remain unclear. objectives: to evaluate the immunohistochemical characteristics of pl and to investigate lesional t-cell subsets and the possible role of viral infection in its pathogenesis. patients and methods: samples from 10 patients with pl et varioliformis acuta (pleva) and 13 with pl chronica (plc) were analyzed immunohistoche ... | 2011 | 21518386 |
| inhibitory molecules that regulate expansion and restoration of hcv-specific cd4+ t cells in patients with chronic infection. | background & aims: inhibitory receptors such as programmed death (pd)-1 and cytotoxic t lymphocyte-associated antigen (ctla)-4 mediate cd8+ t-cell exhaustion during chronic viral infection, but little is known about roles in dysfunction of cd4+ t cells. methods: we investigated the functions of inhibitory molecules on hepatitis c virus (hcv)-, influenza-, and epstein-barr-virus (ebv)-specific cd4+ t cells in patients with chronic infections, compared with patients that resolve hcv infection and ... | 2011 | 21763239 |
| fc?riiia (cd16) induction on human t lymphocytes and cd16pos t-lymphocyte amplification. | during serial assays designed to amplify natural killer (nk) cells in vitro, we observed that when peripheral blood mononuclear cells (pbmcs) from human immunodeficiency virus positive (hiv+) patients were stimulated for 2 weeks with an epstein-barr virus-infected b lymphoblastic cell line and interleukin-2, a well known procedure to amplify nk cells in vitro, 44.4±18% cd3cd16 t lymphocytes were recovered together with nk cells, of which 78.2% expressed an aß t-cell receptor (tcr). to identify t ... | 2011 | 21760529 |
| ebv nuclear antigen ebnalp dismisses transcription repressors ncor and rbpj from enhancers and ebna2 increases ncor-deficient rbpj dna binding. | ebv nuclear antigen 2 (ebna2) and ebv nuclear antigen lp (ebnalp) are critical for b-lymphocyte transformation to lymphoblastoid cell lines (lcls). ebna2 activates transcription through recombination signal-binding immunoglobulin κj region (rbpj), a transcription factor associated with ncor repressive complexes, and ebnalp is implicated in repressor relocalization. ebnalp coactivation with ebna2 was found to dominate over ncor repression. ebnalp associated with ncor and dismissed ncor, ncor and ... | 2011 | 21518914 |
| one year variability of peak heights, heterozygous balance and inter-locus balance for the dna positive control of ampfℓstr© identifiler© str kit. | multivariate analyses of 205 positive control experiments in an ampfℓstr© identifiler© str kit were used to analyze the factors affecting peak heights at 16 loci. peak heights were found to be highly correlated between loci and there was evidence for a difference in sensitivity of the two genetic analyzers in the blue channel. heterozygous balance response at 10 loci was found to behave as a random variable following a beta-distribution with typical median values of 90%, without locus or genetic ... | 2011 | 20457089 |
| early and rapid detection of x-linked lymphoproliferative syndrome with sh2d1a mutations by flow cytometry. | x-linked lymphoproliferative syndrome (xlp) is a rare immunodeficiency with extreme vulnerability to epstein-barr virus (ebv) infection. it presents with fatal infectious mononucleosis, lymphoproliferative disorder, or dysgammaglobulinemia. the majority of affected males have mutations in the sh2d1a/slam-associated protein (sap) gene. we previously generated an antihuman sap monoclonal antibody (kst-3) for a flow cytometric assay and described the activation of t cells to be necessary for the fl ... | 2011 | 20632414 |
| nf-κb as a target for oncogenic viruses. | nf-κb is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. the activity of nf-κb is tightly controlled through its cytoplasmic sequestration by specific inhibitors, iκbs. various cellular stimuli induce the activation of an iκb kinase, which phosphorylates iκbs and triggers their proteasomal degradation, causing nuclear translocation of activated nf-κb. under normal conditions, the activation of nf-κb occurs transiently, thus ensurin ... | 2011 | 20845110 |
| role of human herpes virus 6 in corneal inflammation alone or with human herpesviruses. | : the purpose of this study was to determine the association of human herpes virus 6 (hhv-6) and/or other human herpesviruses in corneal inflammation using polymerase chain reaction (pcr). | 2011 | 20847652 |
| ebv hepatitis in a young crohn's disease patient on prolonged remission with azathioprine. | 2011 | 20848464 | |
| viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents. | limited data are available on characteristics of viral encephalitis in patients after allogeneic stem cell transplantation. | 2011 | 20851868 |
| proteome-wide dysregulation by pra1 depletion delineates a role of pra1 in lipid transport and cell migration. | we have previously identified prenylated rab acceptor 1 (pra1) as a novel cellular interacting partner for epstein-barr virus-encoded oncoprotein, latent membrane protein 1 (lmp1). the intracellular trafficking and full signaling of lmp1 requires its interaction with pra1. to further explore the role of pra1 in epstein-barr virus-associated nasopharyngeal carcinoma (npc) cells, we generated several pra1-knockdown cell clones, which exhibited altered cell morphology and increased cell motility. w ... | 2011 | 20592422 |
| primary intracranial leiomyosarcoma in an hiv-infected patient. | primary intracranial leiomyosarcomas are rare tumors arising from the mesenchymal cells of the dura matter or the cerebral blood vessels. only 14 cases of primary intracranial leiomyosarcoma are reported in the literature. we report a case of primary intracranial leiomyosarcoma in an human immunodeficiency virus-positive patient with a cd4 count of 14 cells/μl. additionally, in-situ hybridization of epstein-barr virus (ebv) early rna stained sections highlighted the tumor cells, consistent with ... | 2011 | 20676716 |
| preparation and validation of the first who international genetic reference panel for fragile x syndrome. | fragile x syndrome is the most common inherited form of mental retardation. it is caused by expansion of a trinucleotide (cgg)n repeat sequence in the 5' untranslated region of the fmr1 gene, resulting in promoter hypermethylation and suppression of fmr1 transcription. additionally, pre-mutation alleles in carrier males and females may result in fragile x tremor ataxia syndrome and primary ovarian insufficiency, respectively. fragile x is one of the most commonly requested molecular genetic test ... | 2011 | 20736975 |
| epstein-barr virus in diffuse large b-cell lymphoma in immunocompetent patients in japan is as low as in western countries. | according to previous reports, the frequency of epstein-barr virus (ebv) positivity in diffuse large b-cell lymphoma is higher in east asia (approximately 9%) than in western countries. the presence of the ebv genome was examined in diffuse large b-cell lymphoma patients registered with the osaka lymphoma study group (olsg) in osaka, japan, situated in east asia. the ebv-positive rate was examined with in situ hybridization (ish) in 484 immunocompetent diffuse large b-cell lymphoma patients regi ... | 2011 | 21181929 |
| clonal x-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma. | splenic hamartoma is a rare tumor-like lesion composed of structurally disorganized red pulp elements. it has been hypothesized that two other splenic lesions, cord capillary hemangioma and myoid angioendothelioma, may fall within the spectrum of splenic hamartoma, simply representing morphological variants. in this study, we compared the vascular and stromal composition of cord capillary hemangioma and myoid angioendothelioma with those of classical hamartoma. in addition, we assessed the clona ... | 2011 | 20852592 |
| vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis. | the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls. | 2011 | 21212086 |
| temporal relationship between environmental influenza a and epstein-barr viral infections and high multiple sclerosis relapse occurrence. | multiple sclerosis (ms) relapses have been associated with viral and bacterial infection epidemics in ms patients who have not used interferon. | 2011 | 21212088 |
| frequency of blood-borne viral infections among leukemic patients in central iraq. | to determine the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv), cytomegalovirus (cmv), epstein-barr virus (ebv), and human immunodeficiency virus (hiv) and other epidemiological criteria among leukemic patients to establish basic knowledge for future leukemic patients care. | 2011 | 21212918 |
| cytomegalovirus and epstein-barr virus-associated post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. | 2011 | 20369358 | |
| salivary epstein-barr virus dna level in patients with nasopharyngeal carcinoma following radiotherapy. | nasopharyngeal carcinoma (npc) is a solid tumor closely associated with epstein-barr virus (ebv) infection. the purpose of this investigation was to detect and quantify the ebv dna level in salivary samples of npc patients following treatment using real-time pcr. a total of 175 consecutive newly diagnosed npc patients' whole saliva samples were collected before treatment, and the ebv dna level was measured by real-time pcr, with the primers and probe targeting the bamhi-w region of the ebv genom ... | 2011 | 21767975 |
| tumor suppressor genes fhit and wwox are deleted in primary effusion lymphoma (pel) cell lines. | primary effusion lymphoma (pel) is a diffuse-large b-cell lymphoma with poor prognosis. one hundred percent of pels carry the genome of kaposi sarcoma-associated herpesvirus and a majority are coinfected with epstein-barr virus (ebv). we profiled genomic aberrations in pel cells using the affymetrix 6.0 snp array. this identified for the first time individual genes that are altered in pel cells. eleven of 13 samples (85%) were deleted for the fragile site tumor suppressors wwox and fhit. alterat ... | 2011 | 21685375 |
| development of the hybrid sleeping beauty-baculovirus vector for sustained gene expression and cancer therapy. | antiangiogenesis is an appealing anticancer approach but requires continued presence of the antiangiogenic agents, which can be remedied by gene therapy. baculovirus is an emerging gene delivery vector but only mediates transient expression (<7 days); thus, this study primarily aimed to develop a hybrid baculovirus for sustained antiangiogenic gene expression and cancer therapy. we first constructed plasmids featuring adeno-associated virus inverted terminal repeats (aav itrs), orip/epstein-barr ... | 2011 | 21918552 |
| a critical role for stat3 transcription factor signaling in the development and maintenance of human t cell memory. | stat3 transcription factor signaling in specific t helper cell differentiation has been well described, although the broader roles for stat3 in lymphocyte memory are less clear. patients with autosomal-dominant hyper-ige syndrome (ad-hies) carry dominant-negative stat3 mutations and are susceptible to a variety of bacterial and fungal infections. we found that ad-hies patients have a cell-intrinsic defect in the number of central memory cd4(+) and cd8(+) t cells compared to healthy controls. nai ... | 2011 | 22118528 |
| Classification of epstein-barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. | Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has not been fully clarified. We analyzed promoter methylation in gastric cancer cases with Illumina's Infinium BeadArray and used hierarchical clustering analysis to classify gastric ca ... | 2011 | 21990320 |
| [lymphomatoid granulomatosis revealed by cutaneous lesions]. | lymphomatoid granulomatosis is a rare epstein barr virus (ebv)-related lymphoproliferative disorder. it most frequently involves the lungs, skin and central nervous system and arises preferentially in patients with immune disorders. here we report a case revealed by cutaneous lesions in an immunocompetent patient. | 2011 | 21893233 |
| identification of the distinctive type i/xhoi+ strain of epstein-barr virus in gastric carcinoma in peru. | to clarify the reason for the low frequency of epstein-barr virus-associated gastric carcinoma (ebvagc) in peru, despite the high frequency reported in neighboring countries, the distribution of the distinctive ebv (type i/xhoi+) strain in ebvagc and a healthy population was examined. | 2011 | 21965785 |
| exhausted cytotoxic control of epstein-barr virus in human lupus. | systemic lupus erythematosus (sle) pathology has long been associated with an increased epstein-barr virus (ebv) seropositivity, viremia and cross-reactive serum antibodies specific for both virus and self. it has therefore been postulated that ebv triggers sle immunopathology, although the mechanism remains elusive. here, we investigate whether frequent peaks of ebv viral load in sle patients are a consequence of dysfunctional anti-ebv cd8+ t cell responses. both inactive and active sle patient ... | 2011 | 22028659 |
| [T-cell large granular lymphocyte leukemia after autologous peripheral blood stem cell transplantation for malignant lymphoma-report of three cases and a review of the literature]. | There have been only three reports in the literature of T-cell large granular lymphocyte (T-LGL) leukemia occurring after autologous peripheral stem cell transplantation (APBSCT). We describe 3 patients in whom a transient monoclonal T-LGL developed after APBSCT for malignant lymphoma. Case 1: A 58-year-old man with peripheral T-cell lymphoma in second complete remission (CR) who underwent APBSCT. Case 2: A 51-year-old man with follicular lymphoma in second CR who underwent APBSCT. Case 3: A 65- ... | 2011 | 21996977 |
| epstein-barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. | recent studies suggest the existence of cancer stem cells (csc) and cancer progenitor cells (cpc), although strict definitions of neither csc nor cpc have been developed. we have produced evidence that the principal oncoprotein of epstein-barr virus (ebv), latent membrane protein 1 (lmp1), which is associated with human malignancies, especially nasopharyngeal carcinoma (npc), promotes tumor cell invasion and metastasis, as well as the epithelial-mesenchymal transition (emt). however, whether lmp ... | 2011 | 21849440 |
| application of a novel highly sensitive activity-based probe for detection of cathepsin g. | cathepsins are crucial in antigen processing in the major histocompatibility complex class ii (mhc ii) pathway. within the proteolytic machinery, three classes of proteases (i.e., cysteine, aspartic, and serine proteases) are present in the endocytic compartments. the combined action of these proteases generates antigenic peptides from antigens, which are loaded to mhc ii molecules for cd4(+) t cell presentation. detection of active serine proteases in primary human antigen-presenting cells (apc ... | 2011 | 22178917 |
| reprogramming of ebv-immortalized b-lymphocyte cell lines into induced pluripotent stem cells. | epstein-barr virus (ebv) immortalized b lymphocyte cell lines have been widely banked for studying a variety of diseases including rare genetic disorders. these cell lines represent an important resource for disease modeling using the induced pluripotent stem cell (ipsc) technology. here we report the generation of ipscs from ebv immortalized b cell lines derived from multiple inherited disease patients via a non-viral method. the reprogramming method for the ebv cell lines involves a distinct p ... | 2011 | 21628406 |
| encephalitis lethargica due to epstein-barr virus infection. | 2011 | 21611982 | |
| immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy. | background: adoptive immunotherapy with ebv-specific ctls (ebv-ctl) has been used to treat ebv-associated nasopharyngeal carcinoma (npc) but only a fraction of the patients shows noticeable clinical response.patients and methods: sixty-seven newly diagnosed npc patients from 2005 to 2007 and 21 healthy donors were collected. immunological parameters and immune function of pbmcs and ebv-ctl were analyzed by flow cytometer analysis (facs) and (51)cr releasing experiment; molecular characteristics ... | 2011 | 21614153 |
| sporadic burkitt lymphoma in southern china: 12 years' experience in a single institution in guangzhou. | aim to analyse the clinicopathological features of sporadic burkitt lymphoma (sbl). methods in a review of 1682 cases of non-hodgkin lymphoma diagnosed in the first affiliated hospital and zhongshan school of medicine, from 1998 to 2010, 20 cases (1.2%) of sbl were identified. histopathological examination, immunohistochemistry and in situ hybridisation were used to analyse the clinicopathological features of these cases. results of the 20 cases of sbl, 18 patients were male and two were female. ... | 2011 | 21653657 |
| lymphoepithelial-like carcinoma of the uterine cervix; a case report. | lymphoepithelioma-like carcinoma (lelc) of the uterine cervix is a rare variant of squamous cell carcinoma of the uterine cervix. this tumor is characterized by nests of poorly differentiated epithelial cells surrounded by a prominent lymphocytic infiltration. despite the poorly differentiated pathological findings, it appears to have a better outcome than the usual squamous cell carcinoma of the uterine cervix. therefore, it is quite important to differentiate this tumor from poorly differentia ... | 2011 | 21797126 |
| epstein-barr virus lmp1 c-terminal activating region-3 contributes to lmp1-mediated cellular migration via its interaction with ubc9. | epstein-barr virus (ebv) latent membrane protein (lmp)-1, the principal viral oncoprotein and a member of the tnfr superfamily, is a constitutively active membrane signaling protein that regulates multiple signal transduction pathways via its c-terminal activating regions (ctar) -1 and -2, and the less studied ctar3. because protein sumoylation among other post-translational modifications may regulate many signaling pathways induced by lmp1, we investigated whether during ebv latency lmp1 regula ... | 2011 | 21795333 |
| expression of ebv encoded viral rna 1, 2 and anti- inflammatory cytokine (interleukin-10) in ffpe lymphoma specimens: a preliminary study for diagnostic implication in pakistan. | abstract: background: epstein barr virus (ebv) plays a significant role as a cofactor in the process of tumorigenesis and has consistently been associated with a variety of malignancies. ebv encoded rnas (eber1 and eber2) are the most abundant viral transcripts in latently ebv-infected cells and their role in viral infection is still unclear. formalin fixed paraffin embedded (ffpe) tissues of surgically removed carcinoma biopsies are widely available form but have never been exploited for expres ... | 2011 | 21791113 |
| cytotoxic cd4+ t cell responses to ebv contrast with cd8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition. | ebv, a b lymphotropic herpesvirus, encodes two immediate early (ie)-, >30 early (e)-, and >30 late (l)-phase proteins during its replication (lytic) cycle. despite this, lytic ag-induced cd8 responses are strongly skewed toward ie and a few e proteins only, all expressed before hla i presentation is blocked in lytically infected cells. for comparison, we examined cd4(+) t cell responses to eight ie, e, or l proteins, screening 14 virus-immune donors to overlapping peptide pools in ifn-γ elispot ... | 2011 | 21622860 |
| piggybac-mediated cancer immunotherapy using ebv-specific cytotoxic t-cells expressing her2-specific chimeric antigen receptor. | epstein-barr virus (ebv)-specific cytotoxic t lymphocytes (ctls) can be modified to function as heterologous tumor directed effector cells that survive longer in vivo than tumor directed t cells without virus specificity, due to chronic stimulation by viral antigens expressed during persistent infection in seropositive individuals. we evaluated the nonviral piggybac (pb) transposon system as a platform for modifying ebv-ctls to express a functional human epidermal growth factor receptor 2-specif ... | 2011 | 21772253 |
| inhibition of the latent membrane protein-1 impairs the growth and tumorigenesis of an ebv-latency ii transformed t-cell. | the epstein-barr virus (ebv) is a common human herpes virus. its infection is associated with several human malignancies where it expresses a set of latent proteins among which is the latent membrane protein lmp1. lmp1 is able to transform numerous cell types and is considered the main oncogenic protein of ebv. the mechanism of action is based on mimicry to activated members of the tnf receptor superfamily, through its ability to bind similar adapters and to activate signaling pathways. we previ ... | 2012 | 22258264 |
| in vitro and in vivo antitumor effect of anti-cd33 chimeric receptor-expressing ebv-ctl against cd33 acute myeloid leukemia. | genetic engineering of t cells with chimeric t-cell receptors (cars) is an attractive strategy to treat malignancies. it extends the range of antigens for adoptive t-cell immunotherapy, and major mechanisms of tumor escape are bypassed. with this strategy we redirected immune responses towards the cd33 antigen to target acute myeloid leukemia. to improve in vivo t-cell persistence, we modified human epstein barr virus-(ebv-) specific cytotoxic t cells with an anti-cd33.car. genetically modified ... | 2012 | 22272203 |
| The lytic phase of epstein-barr virus requires a viral genome with 5-methylcytosine residues in CpG sites. | Epstein-Barr virus (EBV) is a human herpesvirus which has been studied intensively for its role in certain human tumors. It also serves as a model of herpesviral latency because it establishes an immediate, latent infection in human B cells. When EBV infects quiescent, primary B cells it induces their continuous proliferation to yield growth-transformed B-cell lines in vitro. The lytic or productive phase of EBV's life cycle is induced by the expression of the viral BZLF1 gene in latently infect ... | 2012 | 22031942 |
| Understanding TLR9 action in Epstein-Barr virus infection. | The Epstein-Barr virus (EBV) establishes persistent latent infection in peripheral blood memory B cells, may cause infectious mononucleosis, and is associated with cancers including endemic Burkitt's lymphoma (BL). Although latent EBV transforms B cells in vitro, additional factors including immunocompromised status or, as in endemic BL, a co-infection with the malaria parasite Plasmodium falciparum seem to be required for the development of EBV-associated cancers. Toll-like receptors (TLRs) lik ... | 2012 | 22201799 |
| Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in malawian adults with bacterial meningitis. | Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis ... | 2012 | 22075766 |
| Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: A case report and literature review. | T/NK-cell lymphoma of the salivary gland is rare. A 58-year-old man complained of a tumor mass in the left parotid gland region and he was diagnosed to have a left parotid tumor. The tumor was subsequently resected, revealing a diffuse growth pattern of medium to large sized atypical cells. The tumor was surrounded by fibrous connective tissue in the form of a capsule, and those were positive for CD3, CD4, CD5 and CD30, but negative for Bcl2, CD8, CD10, CD15, CD20, CD25, CD56, CD79a, CD246, EMA, ... | 2012 | 22192806 |
| posttransplant lymphoproliferative disorder presenting as multiple cystic lesions in a renal transplant recipient. | we report a case of a 67-year-old man who experienced allograft dysfunction following a renal transplantation from a donation after cardiac death. the postoperative course was initially complicated by episodes of e. coli urinary sepsis causing pyrexia and a raised creatinine level. ultrasound scanning 5 weeks posttransplant revealed mild hydronephrosis with several parenchymal cystic areas measuring up to 2 cm with appearances suggestive of fungal balls. aspirated fluid again grew escherichia co ... | 2012 | 22244123 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |