Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| supranuclear paralysis of voluntary lid closure. | 2015 | 5053249 | |
| [homozygotic beta-thalassemia with 95-100 per cent content of fetal hemoglobin]. | 2016 | 4776306 | |
| [composition of commercial beta-sitosterol products]. | 2016 | 5037298 | |
| [effectiveness and side effects of the treatment of certain dermatoses with methotrexate]. | 2016 | 4782182 | |
| nutrients in university food service meals. i. data determined by food inventory. | 2016 | 5033381 | |
| [personal myringoplastic technic]. | 2016 | 4807357 | |
| [functional state of the myocardium in healthy adolescents according to polycardiographic data]. | 2016 | 4786415 | |
| [treatment of herpes zoster with emetine]. | 2016 | 4767947 | |
| yolk sac tumor associated with seminoma of the testis in adults. | 2016 | 4823489 | |
| effect of 5-imino-2,2,4,4-tetrakis (trifluoromethyl) imidazolidine (exp 338) on spasticity: a quantitative evaluation. | 2016 | 4871898 | |
| theory of chromatography of rigid rod-like macromolecules on hydroxyapatite columns. ii. the case of several molecular species. | 2016 | 4723053 | |
| letter: echocardiography of mitral valve prolapse. | 2016 | 4813196 | |
| tissue-air ratios for rotational therapy with 32-mev x rays. | 2016 | 4986893 | |
| care and raising of newborn baboons. | 2016 | 4967710 | |
| [lazar' izrailevich fogel'son (on his 80th birthday)]. | 2016 | 4932316 | |
| diagnostic evaluation of ecg data by a computer. | 2016 | 4931051 | |
| [immunologic studies in a case of postmolar choriocarcinoma]. | 2016 | 4889042 | |
| effects of the uricogenic agent, 2-ethylamino-1,3,4-thiadiazole in hypoxanthine-guanine phosphoribosyl transferase deficiency. | 2016 | 4877987 | |
| pyloric function and gall-stone dyspepsia. | 2016 | 5031191 | |
| national center for urban and industrial health. | 2016 | 4960589 | |
| chronic hepatitis. | 2016 | 4945079 | |
| enzyme pattern of macrophages in the course of inflammation. | 2016 | 4887032 | |
| [experimental data on the existence and significance of an anticoagulating system in fish]. | 2016 | 4824513 | |
| [ocular effects of tear gases containing ethyl bromacetate]. | 2016 | 4803749 | |
| [spectrophotometric method for the quantitative analysis of some drug mixtures with purine alkaloids]. | 2016 | 4792451 | |
| the complications of low-friction arthroplasty of the hip in the elderly. | 2016 | 4775954 | |
| serum copper as an index of tumor response to radiotherapy. | 2016 | 4734340 | |
| ion concentration profile normal to cell membrane. | 2016 | 5090351 | |
| marihuana--a smoke screen. | 2016 | 5063403 | |
| e.m.g. evidence of compensatory innervation by contralateral nerve in facial palsy. | 2016 | 4840379 | |
| photoinactivation using visible light plus water-filtered infrared-a (vis+wira) and chlorine e6 (ce6) eradicates planktonic periodontal pathogens and subgingival biofilms. | alternative treatment methods for pathogens and microbial biofilms are required due to the widespread rise in antibiotic resistance. antimicrobial photodynamic therapy (apdt) has recently gained attention as a novel method to eradicate pathogens. the aim of this study was to evaluate the antimicrobial effects of a novel apdt method using visible light (vis) and water infiltrated infrared a (wira) in combination with chlorine e6 (ce6) against different periodontal pathogens in planktonic form and ... | 2016 | 27965635 |
| antimicrobial effect of chlorhexidine on aggregatibacter actinomycetemcomitans biofilms associated with peri-implantitis. | background. this study aimed to assessthe antimicrobial effect of chlorhexidine (chx) on aggregatibacter actinomycetemcomitans biofilms isolated from subgingival plaque of peri-implantitis lesions. methods. thirteen patients requiring peri-implantitis treatment were consecutively selected and their subgingival biofilm was collected by inserting fine sterile paper points into peri-implant pockets for 15 seconds. a. actinomycetemcomitans was isolated from the subgingival biofilm and cultured. in t ... | 2016 | 27651884 |
| quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults. | in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ... | 2016 | 27313576 |
| frequency of periodontal pathogens and helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study. | this cross-sectional study compared the frequency of oral periodontopathogens and h. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. | 2016 | 27383704 |
| nonsyndromic localized aggressive periodontitis of primary dentition: a rare case report. | periodontitis is an inflammatory disease of the gingiva and tissues of the periodontium. it is characterized by pocket formation and destruction of supporting alveolar bone. periodontal diseases of aggressive nature are not very common in children. they are usually associated with systemic conditions. the present case report is of a 5-year-old male child who reported with rapid attachment loss and bony defects of the gingiva and supporting structures. his family and medical history gave no contr ... | 2016 | 27307682 |
| accuracy of commercial kits and published primer pairs for the detection of periodontopathogens. | despite the input of microbiome research, a group of 20 bacteria continues to be the focus of periodontal diagnostics and therapy. the aim of this study was to compare three commercial kits and laboratory-developed primer pairs for effectiveness in detecting such periodontopathogens. | 2016 | 27020914 |
| microbiological efficacy of photodynamic therapy as an adjunct to non-surgical periodontal treatment: a clinical trial. | the efficiency of routine scaling and root planning is negatively influenced by the tooth anatomy and residual bacteria all possibly affecting the treatment outcomes in future. the present study compared the microbiologic effectiveness of the photodynamic therapy (pdt) as an adjunctive treatment modality for nonsurgical treatment in chronic periodontitis. | 2016 | 27330709 |
| genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. | genome-wide association studies (gwas) of chronic periodontitis (cp) defined by clinical criteria alone have had modest success to-date. here, we refine the cp phenotype by supplementing clinical data with biological intermediates of microbial burden (levels of eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid il-1β) and derive periodontal complex traits (pcts) via principal component analysis. pcts were carried forward to gwas (∼2.5 million markers) to iden ... | 2016 | 26962152 |
| [thromboangiitis obliterans. pathological anatomy and symptomatology. historical notes]. | 2016 | 4889644 | |
| full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: a pilot study. | the evidence of effectiveness of metronidazole (mtz) as an adjunct therapy to periodontal procedure in the treatment of patients with chronic periodontitis is not conclusive. the aim of this study was to compare the effect of mtz (delivered locally as a gel or systemically as a tablet) as an adjunctive therapy with full mouth periodontal debridement (1 h of ultrasonic calculus/plaque removal) in smokers with chronic periodontitis. | 2016 | 25900347 |
| periodontal inflammation and alveolar bone loss induced by aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. | sphingosine-1-phosphate (s1p) is a bioactive sphingolipid, which is generated by activation of sphingosine kinase (sk) 1 and/or 2 in most mammalian cells with various stimuli, including the oral pathogen aggregatibacter actinomycetemcomitans. s1p signaling has been shown to regulate the migration of monocytes and macrophages (osteoclast precursors) from the circulation to bone tissues and affect bone homeostasis. we aimed to determine the effects of sk1 deficiency on s1p generation, proinflammat ... | 2016 | 25900155 |
| serotype b of aggregatibacter actinomycetemcomitans increases osteoclast and memory t-lymphocyte activation. | during periodontitis, alveolar bone resorption is associated with activation of t helper type 17 (th17) lymphocytes and receptor activator of nuclear factor-κb ligand (rankl) -induced osteoclasts. we previously reported that serotype b of aggregatibacter actinomycetemcomitans has a higher capacity to trigger th17-type differentiation and function in activated t lymphocytes and its lipopolysaccharide is a more potent immunogen compared with the other serotypes. this study aimed to investigate whe ... | 2016 | 26172400 |
| aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. | aggregatibacter actinomycetemcomitans is a perio-pathogenic bacteria that has long been associated with localized aggressive periodontitis. the mechanisms of its pathogenicity have been studied in humans and preclinical experimental models. although different serotypes of a. actinomycetemcomitans have differential virulence factor expression, a. actinomycetemcomitans cytolethal distending toxin (cdt), leukotoxin, and lipopolysaccharide (lps) have been most extensively studied in the context of m ... | 2016 | 26197893 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| gingival mesenchymal stem cell (gmsc) delivery system based on rgd-coupled alginate hydrogel with antimicrobial properties: a novel treatment modality for peri-implantitis. | peri-implantitis is one of the most common inflammatory complications in dental implantology. similar to periodontitis, in peri-implantitis, destructive inflammatory changes take place in the tissues surrounding a dental implant. bacterial flora at the failing implant sites resemble the pathogens in periodontal disease and consist of gram-negative anaerobic bacteria including aggregatibacter actinomycetemcomitans (aa). here we demonstrate the effectiveness of a silver lactate (sl)-containing rgd ... | 2016 | 26216081 |
| the toxicity of the aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity. | the aggregatibacter actinomycetemcomitans cytolethal distending toxin (cdt) induces g2 arrest and apoptosis in lymphocytes and other cell types. we have shown that the active subunit, cdtb, exhibits phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase activity, leading us to propose that cdt toxicity is the result of pip3 depletion and perturbation of phosphatidylinositol-3-kinase (pi-3k)/pip3/akt signalling. to further explore this relationship, we have focused our analysis on identifying ... | 2016 | 26247396 |
| microbiologic and clinical findings of implants in healthy condition and with peri-implantitis. | to compare implants in healthy conditions and implants with peri-implantitis with regard to their clinical parameters and the microbiologic composition at the peri-implant sulcus, inside the implant connection, and the gingival sulcus of neighboring teeth. | 2016 | 26252036 |
| lymphoid susceptibility to the aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate. | the aggregatibacter actinomycetemcomitans cytolethal distending toxin (cdt) induces g2 arrest and apoptosis in lymphocytes and other cell types. we have shown that the active subunit, cdtb, exhibits phosphatidylinositol-3,4,5-triphosphate (pip3) phosphatase activity and depletes lymphoid cells of pip3. hence we propose that cdt toxicity results from depletion of this signaling lipid and perturbation of phosphatidylinositol-3-kinase (pi-3k)/pip3/akt signaling. we have now focused on the relations ... | 2016 | 26299277 |
| investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes. | the aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (pku) and type 1 diabetes compared to healthy children. | 2016 | 26297129 |
| aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in lfa-1 expressing immune cells. | studies have suggested that aggregatibacter actinomycetemcomitans leukotoxin (ltxa) kills human lymphocyte function-associated antigen 1 (lfa-1; cd11a/cd18)-bearing immune cells through a lysosomal-mediated mechanism. lysosomes are membrane-bound cellular organelles that contain an array of acid hydrolases that are capable of breaking down biomolecules. the lysosomal membrane bilayer confines the ph-sensitive enzymes within an optimal acidic (ph 4.8) environment thereby protecting the slightly b ... | 2016 | 26361372 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |
| evolutionary divergence of aggregatibacter actinomycetemcomitans. | gram-negative facultative aggregatibacter actinomycetemcomitans is an oral pathogen associated with periodontitis. the genetic heterogeneity among a. actinomycetemcomitans strains has been long recognized. this study provides a comprehensive genomic analysis of a. actinomycetemcomitans and the closely related nonpathogenic aggregatibacter aphrophilus. whole genome sequencing by illumina miseq platform was performed for 31 a. actinomycetemcomitans and 2 a. aphrophilus strains. sequence similarity ... | 2016 | 26420795 |
| antibacterial activity of curcumin against periodontopathic bacteria. | curcumin is a polyphenol extracted from root of turmeric and known to possess multifunctional properties, including antibacterial activity. although previous studies have investigated the effects of curcumin on microorganisms, available knowledge on the effects of curcumin on periodontopathic bacteria is still limited. in this study, the antibacterial effect of curcumin on periodontopathic bacteria is investigated, particularly porphyromonas gingivalis. | 2016 | 26447754 |
| secreted adenosine triphosphate from aggregatibacter actinomycetemcomitans triggers chemokine response. | extracellular atp (eatp) is an important intercellular signaling molecule secreted by activated immune cells or released by damaged cells. in mammalian cells, a rapid increase of atp concentration in the extracellular space sends a danger signal, which alerts the immune system of an impending danger, resulting in recruitment and priming of phagocytes. recent studies show that bacteria also release atp into the extracellular milieu, suggesting a potential role for eatp in host-microbe interaction ... | 2016 | 26470857 |
| oral microbiota, periodontal status, and osteoporosis in postmenopausal females. | alterations in hormone levels during menopause decrease bone density and may worsen oral health, favoring the growth of periodontal pathogens, whose detection could improve the diagnosis of periodontitis. the aim of this study is to detect and quantify the main periodontal pathogens in the oral microbiota of postmenopausal females and to explore the relationship between clinical and periodontal parameters. | 2016 | 26469811 |
| occurrence and serotype distribution of aggregatibacter actinomycetemcomitans in subjects without periodontitis in turkey. | to determine the occurrence and serotype distribution of aggregatibacter actinomycetemcomitans in subjects without periodontitis. | 2016 | 26556547 |
| bacterial inactivation/sterilization by argon plasma treatment on contaminated titanium implant surfaces: in vitro study. | surface treatment by argon plasma is widely used as the last step of the manufacturing process of titanium implant fixtures before their sterilization by gamma rays. the possibility of using such a technology in the daily clinical practice is particularly fascinating. the aim of the present study was to assess the effects of the argon plasma treatment on different titanium implant surfaces previously exposed in vitro to bacterial contamination. | 2016 | 26595834 |
| characterization of a. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in morocco. | aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (jp2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. the aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbiota of periodontitis patients from morocco and to describe the clinical and microbiological characteristics of subjects positive for a. actinomycetemcomitans, including serotype, leukotoxin g ... | 2016 | 26592810 |
| the distribution of porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans in patients with alcoholic disease: a pilot study. | both drinking and periodontal disease are serious health and social problems. findings on the effect of alcohol consumption on periodontal disease are inconclusive. | 2016 | 27627556 |
| mannose-binding lectin gene polymorphism in relation to periodontal infection. | mannose-binding lectin (mbl) plays an important role in innate immunity. mbl deficiency is usually caused by mutations in exon 1 of the mbl structural gene (mbl2). our aim was to investigate mbl2 polymorphisms and their relation to salivary levels of periodontal inflammatory/tissue destruction markers and two major periodontitis-associated bacteria. | 2016 | 27624657 |
| short-term microbiological effects of photodynamic therapy in non-surgical periodontal treatment of residual pockets: a split-mouth rct. | photodynamic therapy (pdt) has been used as a therapeutic alternative to treat periodontitis, especially in challenging sites that require additional periodontal therapy such as residual pockets. the aim of this split-mouth randomized trial was to evaluate the microbiological and clinical effects of pdt on non-surgical treatment of unresponsive pockets. | 2016 | 26660720 |
| the jp2 genotype of aggregatibacter actinomycetemcomitans and marginal periodontitis in the mixed dentition. | to perform a cross-sectional study on the carrier frequency of jp2 and non-jp2 genotypes of a. actinomycetemcomitans in moroccan school children and relate the presence of these genotypes to the periodontal status in the mixed dentition. | 2016 | 26659719 |
| effect of periodontitis on adiponectin, c-reactive protein, and immunoglobulin g against porphyromonas gingivalis in thai people with overweight or obese status. | obesity and periodontitis are associated with an inflammatory background. inflammatory mediators involved may have reciprocal effects on one another. in this study, the levels of inflammatory mediators implicated in overweight or obese status and periodontitis are simultaneously evaluated. | 2016 | 26654348 |
| periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary sjögren's syndrome: a pilot study. | the aims of this study were as follows: (i) to assess the prevalence of periodontitis among patients with primary sjögren's syndrome (pss) and comparator groups of patients with rheumatoid arthritis (ra) and osteoarthritis (oa). (ii) to perform a pilot study to compare serum antibody responses to 10 oral/periodontal bacteria in these patient groups and a historical comparator group of patients with periodontitis. | 2016 | 26646777 |
| neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease. | cardiovascular diseases are chronic inflammatory diseases that affect a large segment of society. coronary heart disease (chd), the most common cardiovascular disease, progresses over several years and affects millions of people worldwide. chronic infections may contribute to the systemic inflammation and enhance the risk for chd. periodontitis is one of the most common chronic infections that affects up to 50% of the adult population. under inflammatory conditions the activation of endogenous d ... | 2016 | 26608308 |
| changes in salivary periodontal pathogens after orthodontic treatment: an in vivo prospective study. | to analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. | 2016 | 26606331 |
| herpesviral-bacterial co-infection in mandibular third molar pericoronitis. | the aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. | 2016 | 27620215 |
| role of nod2 and rip2 in host-microbe interactions with gram-negative bacteria: insights from the periodontal disease model. | nod2 is a member of the nlr family of proteins that participate in the activation of the innate immune response. rip2 is a downstream kinase activated by both nod1 and nod2. there is scarcity of information regarding the relevance of nod2 in periodontitis, a chronic inflammatory condition characterized by inflammatory bone resorption. we used nod2-ko and rip2-ko mice in a model of microbial-induced periodontitis. heat-killed aggregatibacter actinomycetemcomitans was injected in the gingival tiss ... | 2016 | 27605548 |
| effect of helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. | helicobacter pylori (h. pylori), a pathogen inducing peptic disease, is recently found to be binding to the progress of periodontitis. most previous studies are case-controlled, and they investigate the risk of h. pylori infection in disease the development of while few studies evaluate the correlation between h. pylori and periodontal pathogens. therefore, we investigated the correlation between h. pylori infection with periodontal parameters, periodontal pathogens and inflammation. the results ... | 2016 | 27602578 |
| micrornas regulate cytokine responses in gingival epithelial cells. | micrornas (mirnas) have been established as key regulators of various biological processes with possible involvement in the pathobiology of periodontal disease. expanding our earlier observations of substantial differential expression of specific mirnas between clinically healthy and periodontitis-affected gingival tissues, we used mirna inhibitors (sponges) in loss-of-function experiments to investigate the involvement of specific mirnas in the response of pocket epithelium-derived, telomerase- ... | 2016 | 27600506 |
| detection of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans after systemic administration of amoxicillin plus metronidazole as an adjunct to non-surgical periodontal therapy: a systematic review and meta-analysis. | to evaluate the variations in the detection of porphyromonas gingivalis and/or aggregatibacter actinomycetemcomitans before and after systemic administration of amoxicillin plus metronidazole in association with non-surgical periodontal therapy (nspt). | 2016 | 27594851 |
| adhesion of periodontal pathogens to self-ligating orthodontic brackets: an in-vivo prospective study. | our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (clarity-sl [csl], clippy-c [cc] and damon q [dq]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. | 2016 | 27585775 |
| novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. | the purpose of this investigation was to determine the ability of tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-associated pathogens [i.e., porphyromonas gingivalis (pg), fusobacterium nucleatum (fn), prevotella intermedia (pi), and aggregatibacter actinomycetemcomitans (aa)]. tetracycline hydrochloride (tch) was added to a poly(dl-lactide) [pla], poly(ε-caprolactone) [pcl], and gelatin [gel] polymer blend solution at distinct concentrations to obtain the follow ... | 2016 | 27585669 |
| d-galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens. | autoinducer 2 (ai-2) is a quorum sensing molecule to which bacteria respond to regulate various phenotypes, including virulence and biofilm formation. ai-2 plays an important role in the formation of a subgingival biofilm composed mostly of gram-negative anaerobes, by which periodontitis is initiated. the aim of this study was to evaluate d-galactose as an inhibitor of ai-2 activity and thus of the biofilm formation of periodontopathogens. in a search for an ai-2 receptor of fusobacterium nuclea ... | 2016 | 27572513 |
| prevalence of periodontopathogens and candida spp. in smokers after nonsurgical periodontal therapy - a pilot study. | this pilot study aimed to evaluate the influence of smoking on clinical and microbiological parameters after nonsurgical periodontal therapy. forty-eight subjects were grouped into smokers (sm, n = 24) and nonsmokers (ns, n = 24) and paired according to gender, age, ethnicity, and periodontal status. both groups received oral hygiene education and scaling and root planing. clinical evaluation was performed using plaque index (pi), bleeding on probing (bop), pocket probing depth (ppd), gingival r ... | 2016 | 27556680 |
| longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. | this study was aimed to provide a longitudinal overview of the subgingival bacterial microbiome using fluorescence in situ hybridization (fish) technique, in women in the second trimester of pregnancy (between 14 and 24 weeks), and 48 h and 8 weeks postpartum. of 31 women evaluated during pregnancy, 24 returned for the 48-h and 18 for their 8-week exams postpartum. probing depth (pd), bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque sampl ... | 2016 | 27556678 |
| melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. | alveolar bone loss is a result of an aggressive form of periodontal disease (pd) associated with aggregatibacter actinomycetemcomitans (aa) infection. pd is often observed with other systemic inflammatory conditions, including arthritis. melanocortin peptides activate specific receptors to exert antiarthritic properties, avoiding excessing inflammation and modulating macrophage function. recent work has indicated that melanocortin can control osteoclast development and function, but whether such ... | 2016 | 27535487 |
| oxygen as a virulence determinant in polymicrobial infections. | infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. stacy et al. (a. stacy, d. fleming, r. j. lamont, k. p. rumbaugh, and m. whiteley, mbio 7:e00782-16, 2016, http://dx.doi.org/10.1128/mbio.00782-16) described a novel mechanism that results in synergisti ... | 2016 | 27531913 |
| inhibition of p2x receptors protects human monocytes against damage by leukotoxin from aggregatibacter actinomycetemcomitans and α-hemolysin from escherichia coli. | α-hemolysin (hlya) from escherichia coli and leukotoxin a (ltxa) from aggregatibacter actinomycetemcomitans are important virulence factors in ascending urinary tract infections and aggressive periodontitis, respectively. the extracellular signaling molecule atp is released immediately after insertion of the toxins into plasma membranes and, via p2x receptors, is essential for the erythrocyte damage inflicted by these toxins. moreover, atp signaling is required for the ensuing recognition and ph ... | 2016 | 27528275 |
| human serum-specific activation of alternative sigma factors, the stress responders in aggregatibacter actinomycetemcomitans. | aggregatibacter actinomycetemcomitans, a known pathogen causing periodontal disease and infective endocarditis, is a survivor in the periodontal pocket and blood stream; both environments contain serum as a nutrient source. to screen for unknown virulence factors associated with this microorganism, a. actinomycetemcomitans was grown in serum-based media to simulate its in vivo environment. different strains of a. actinomycetemcomitans showed distinct growth phenotypes only in the presence of hum ... | 2016 | 27490177 |
| transcriptome analysis of b cell immune functions in periodontitis: mucosal tissue responses to the oral microbiome in aging. | evidence has shown activation of t and b cells in gingival tissues in experimental models and in humans diagnosed with periodontitis. the results of this adaptive immune response are noted both locally and systemically with antigenic specificity for an array of oral bacteria, including periodontopathic species, e.g., porphyromonas gingivalis and aggregatibacter actinomycetemcomitans. it has been recognized through epidemiological studies and clinical observations that the prevalence of periodont ... | 2016 | 27486459 |
| detection of selected periodontal bacteria in preschool children affected by early childhood caries. | the aim of this study was to compare the detection frequency of periodontal bacteria in dental plaque in children with early childhood caries (ecc) with and without gingival inflammation. a convenience sample of 25 preschool children (mean age 3.61 years, sd 1.42) was recruited. dental plaque was taken from periodontal areas with and without visible signs of inflammation and processed using the stomagene® (protean s.r.o. czech republic) and parocheck® 20 (greiner bio-one gmbh, germany) detection ... | 2016 | 27485551 |
| oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins. | the impact of oral pathogens onto the generation and variability of oral tumors has only recently been investigated. to get further insights, oral cancer cells were treated with pathogens and additionally, as a result of this bacterial cellular infection, with human defensins, which are as anti-microbial peptide members of the innate immune system. after cell stimulation, proliferation behavior, expression analysis of oncogenic relevant defensin genes, and effects on egfr signaling were investig ... | 2016 | 27481514 |
| nucleases from prevotella intermedia can degrade neutrophil extracellular traps. | periodontitis is an inflammatory disease caused by periodontal bacteria in subgingival plaque. these bacteria are able to colonize the periodontal region by evading the host immune response. neutrophils, the host's first line of defense against infection, use various strategies to kill invading pathogens, including neutrophil extracellular traps (nets). these are extracellular net-like fibers comprising dna and antimicrobial components such as histones, ll-37, defensins, myeloperoxidase, and neu ... | 2016 | 27476978 |
| an assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. | numerous studies have proposed that smooth metal surfaces reduce initial bacterial attachment in the establishment of an early biofilm formation. however, these studies have largely examined single bacterial species, which are not always relevant as pathogens identified as initiators of inflammatory peri-implantitis. this study investigated the adherence of four periodontally-relevant bacterial species to implant and abutment surfaces in current clinical use. | 2016 | 27472955 |
| bacterial load of periodontal pathogens among italian patients with chronic periodontitis: a comparative study of three different areas. | the aim of the present study was to evaluate the mean bacterial load of some periodontal pathogenic bacteria in italian patients affected by chronic periodontitis. the sample consisted of 1,762 patients with a clinical diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology sampled in the period 2013-2015; 1,323 patients were from northern italy, 317 from central italy and 122 from southern italy. samples for microbiological analysis were collected from ... | 2016 | 27469562 |
| evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using pcr analysis: a microbiological pilot study. | the use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. over the last few years, carvacrol and thymol (ct) have been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of ct on the red complex bacteria using polymerase chain reaction (pcr) for microbiological analysis. five patients with a diagnosis of chronic periodontitis in the age grou ... | 2016 | 27469559 |
| oxygen high level laser therapy is efficient in treatment of chronic periodontitis: a clinical and microbiological study using pcr analysis. | in periodontology, lasers have been suggested for the photodynamic therapy (pdt). such therapy can be defined as the inactivation of cells, microorganisms or molecules induced by light and not by heat. the aim of our study is to assess the effect of oxygen high-level laser therapy (ohllt) in removing all bacterial deposits on root or implant surface by means of mechanical instrumentation and laser irradiation. ohllt has two effects on targeted bacteria and tissues, decontamination and biostimula ... | 2016 | 27469554 |
| fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. | to manufacture and assess bioactivity of low fluoride/high phosphate (low f(-)/high p2o5) bioglasses (bgs). then the effects of bg-conditioned medium on osteoblast-like cell behavior and bg particles on bactericidal activity were investigated. | 2016 | 27461261 |
| quantifying implant-associated biofilms: comparison of microscopic, microbiologic and biochemical methods. | biofilm-associated infections pose severe problems in modern implant medicine. screening for new implant materials with antibacterial properties requires reliable quantification of colonizing bacteria. there are many different methods to quantify biofilms on solid surfaces in vitro, employing different (bio-)chemical/microbiological reference parameters. it is therefore difficult to compare studies with different quantification techniques. here, we have evaluated commonly used microscopic, micro ... | 2016 | 27444546 |
| a cytolethal distending toxin variant from aggregatibacter actinomycetemcomitans with an aberrant cdtb that lacks the conserved catalytic histidine 160. | the periodontopathogen aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (cdt). the active cdt holoenzyme is an ab-type tripartite genotoxin that affects eukaryotic cells. subunits cdta and cdtc (b-components) allow binding and intracellular translocation of the active cdtb (a-component), which elicits nuclear dna damage. different strains of a. actinomycetemcomitans have diverse virulence genotypes, which results in varied pathoge ... | 2016 | 27414641 |
| antimicrobial effect of platelet-rich plasma and platelet-rich fibrin. | platelet concentrates have been extensively used in a variety of medical fields to promote soft- and hard-tissue regeneration. the significance behind their use lies in the abundance of growth factors (gfs) in platelets α-granules that promote wound healing. other than releasing a pool of gfs upon activation, platelets also have many features that indicate their role in the anti-infective host defense. | 2016 | 27411660 |
| interactions between lactobacillus rhamnosus gg and oral micro-organisms in an in vitro biofilm model. | probiotics have shown favourable properties in maintaining oral health. by interacting with oral microbial communities, these species could contribute to healthier microbial equilibrium. this study aimed to investigate in vitro the ability of probiotic lactobacillus rhamnosus gg (l.gg) to integrate in oral biofilm and affect its species composition. five oral strains, streptococcus mutans, streptococcus sanguinis, aggregatibacter actinomycetemcomitans, fusobacterium nucleatum and candida albican ... | 2016 | 27405227 |
| biofilm formation of periodontal pathogens on hydroxyapatite surfaces: implications for periodontium damage. | biofilm formation of periodontal pathogens on teeth surfaces promotes the progression of periodontal disease. hence, understanding the mechanisms of bacterial attachment to the dental surfaces may inform strategies for the maintenance of oral health. although hydroxyapatite (ha) is a major calcium phosphate component of teeth, effect of biofilm formation on ha surfaces remains poorly characterized. in this study, biofilm-forming abilities by the periodontal pathogens aggregatibacter actinomycete ... | 2016 | 27390886 |
| a commensal bacterium promotes virulence of an opportunistic pathogen via cross-respiration. | bacteria rarely inhabit infection sites alone, instead residing in diverse, multispecies communities. despite this fact, bacterial pathogenesis studies primarily focus on monoculture infections, overlooking how community interactions influence the course of disease. in this study, we used global mutant fitness profiling (transposon sequencing [tn-seq]) to determine the genetic requirements for the pathogenic bacterium aggregatibacter actinomycetemcomitans to cause disease when coinfecting with t ... | 2016 | 27353758 |
| fine-tuned production of hydrogen peroxide promotes biofilm formation of streptococcus parasanguinis by a pathogenic cohabitant aggregatibacter actinomycetemcomitans. | balanced bacterial biofilm communities help to maintain host health. disturbance of such balance can lead to bacterial dysbiosis and pathogenesis. however, complex and dynamic bacterial interactions within the biofilm communities are poorly understood. in this study, we used a dual-species biofilm consisting of the periodontal pathogen aggregatibacter actinomycetemcomitans, and a commensal streptococcus parasanguinis to investigate bacterial interactions since the two organisms have been found t ... | 2016 | 27348605 |
| is mechanical curettage with adjunct photodynamic therapy more effective in the treatment of peri-implantitis than mechanical curettage alone? | the aim of the present study was to review the pertinent literature on the effects of mechanical curettage (mc) with and without adjunct photodynamic therapy (pdt) for the management of peri-implantitis. | 2016 | 27344944 |
| periodontitis-associated pathogens p. gingivalis and a. actinomycetemcomitans activate human cd14(+) monocytes leading to enhanced th17/il-17 responses. | the th17/il-17 pathway is implicated in the pathogenesis of periodontitis (pd), however the mechanisms are not fully understood. we investigated the mechanism by which the periodontal pathogens porphyromonas gingivalis (pg) and aggregatibacter actinomycetemcomitans (aa) promote a th17/il-17 response in vitro, and studied il-17(+) cd4(+) t-cell frequencies in gingival tissue and peripheral blood from patients with pd versus periodontally healthy controls. addition of pg or aa to monocyte/cd4(+) t ... | 2016 | 27334899 |
| an in vitro comparison of antimicrobial effects of curcumin-based photodynamic therapy and chlorhexidine, on aggregatibacter actinomycetemcomitans. | considering the importance of prevention in periodontal diseases and the important role of aggregatibacter actinomycetemcomitans in induction and progression of these diseases, the aim of the present in vitro study was to compare the antimicrobial effects of chlorhexidine digluconate (chx), curcumin and light-emitting diode (led) laser, on this bacterium. | 2016 | 27330693 |
| periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the french registry of acute st-elevation and non-st-elevation myocardial infarction (fast-mi). | periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (ami). the present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (mi) at 1 year in 975 patients admitted for acute st segment or non-st segment elevation mi in french registry of ac ... | 2016 | 27325868 |