Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| squamous cell carcinoma of the scalp associated with human papillomavirus type 16. | 2011 | 21896422 | |
| comparison of the immunogenicity of the human papillomavirus (hpv)-16/18 vaccine and the hpv-6/11/16/18 vaccine for oncogenic non-vaccine types hpv-31 and hpv-45 in healthy women aged 18-45 years. | protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (hpv) vaccines may provide a significant medical benefit. available clinical efficacy data suggest the two licensed vaccines (hpv-16/18 vaccine, glaxosmithkline biologicals [gsk], and hpv-6/11/16/18 vaccine, merck & co., inc.) differ in terms of protection against oncogenic non-vaccine hpv types -31/45. the immune responses induced by the two vaccines against these two non-vaccine hpv types (cross-r ... | 2011 | 22048172 |
| persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. | human papillomavirus (hpv) persistence is the pivotal event in cervical carcinogenesis. we followed a large-scale community-based cohort for 16 years to investigate the role of genotype-specific hpv persistence in predicting cervical cancer including invasive and in situ carcinoma. | 2011 | 21900119 |
| Codon usage roles in human papillomavirus. | Human papillomavirus (HPV) genomes, similar to other virus genomes, frequently have a G + C content significantly different from their host species. The HPV genomes show a strong codon usage bias to 18 codons, with 14 showing T at the third position amongst degenerately encoded amino acids. The codon usage pattern in HPV genome plays an important role, which regulates low or non-translational expression of the viral capsid genes and results in very weak protein expression of oncogenes in a wide ... | 2011 | 22025363 |
| Comparison of the INNO-LiPA and PapType assays for detection of human papillomavirus in archival vulva dysplasia and/or neoplasia tissue biopsy specimens. | INNO-LiPA and PapType human papillomavirus (HPV) genotyping assays were compared for detection of HPV genotypes on archival vulvar tissue. The INNO-LiPA assay detected 49 HPV-16 infections, compared with 47 detected by the PapType assay. The INNO-LiPA assay detected amplifiable DNA in 59 (91%) biopsy specimens, compared with 57 (88%) specimens for which amplifiable DNA was detected by the PapType assay. The two genotyping assays were highly comparable. | 2011 | 21940480 |
| comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model. | to compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (hpv) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to hpv types 6 and 11, and reported long term immunogenicity. | 2011 | 21951758 |
| Loss of the a2ß1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. | Expression of the a2ß1 integrin, a receptor for collagens and laminin, is altered during tumor progression. Recent studies have linked polymorphisms in the a2 integrin gene with oral, squamous cell carcinoma (SCC). To determine the a2ß1 integrin's role in SCC progression, we crossed a2-null mice with K14-HPV16 transgenic animals. Pathological progression to invasive carcinoma was evaluated in HPV-positive, a2-null (HPV/KO) and HPV-positive, wild-type (HPV/WT) animals. a2ß1 integrin expression st ... | 2011 | 22046385 |
| Incorporating Calibrated Model Parameters into Sensitivity Analyses: Deterministic and Probabilistic Approaches. | Objective: The aim of this study was to examine how calibration uncertainty affects the overall uncertainty of a mathematical model and to evaluate potential drivers of calibration uncertainty. Methods: A lifetime Markov model of the natural history of human papillomavirus (HPV) infection and cervical disease was developed to assess the cost effectiveness of a hypothetical HPV vaccine. Published data on cervical cancer incidence and mortality and prevalence of pre-cursor lesions were used as end ... | 2011 | 22149631 |
| cervical cancer in the screening era: who fell victim in spite of successful screening programs? | to compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. by analyzing these profiles we hope to improve future screening methods. | 2011 | 21860732 |
| The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region. | The human papillomavirus type 16 (HPV-16) E5 oncoprotein is embedded in membranes of the endoplasmic reticulum and nuclear envelope with its C terminus exposed to the cytoplasm. Among other activities, E5 cooperates with the HPV E6 oncoprotein to induce koilocytosis in human cervical cells and keratinocytes in vitro. The effect of E5 on infected cells may rely on its interactions with various cellular proteins. In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-b ... | 2011 | 21849434 |
| human papillomavirus type-specific prevalence in women with cervical intraepithelial neoplasm in western china. | hpv type-specific prevalence was studied in 600 cases of cervical intraepithelial neoplasm in western china by genoarray test. hpv 16 and 58 were the most prevalent types with the prevalence of 37.8% or 21.8% respectively. hpv 18 or 45 was uncommon type. the result shows different type distributions from that of other regions, which is important evidence for the selection of future genotypes in hpv vaccines in western china. | 2011 | 22170939 |
| Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes. | ABSTRACT: BACKGROUND: The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated t ... | 2011 | 22118413 |
| [results of the first human papilloma virus center in hungary (2007-2011)]. | human papilloma virus (hpv) is the most common sexually transmitted infection in the 21st century. it has been established that infections with specific hpv types are contributing factors to cervical cancer. approximately 99.7% of cervical cancers are associated with high risk hpv types. hpv testing plays an important role in the prevention, by decreasing the prevalence and the mortality of cervical cancer. there are 16 hpv-centers operating in hungary, in which patients undergo hpv screening, c ... | 2011 | 22011366 |
| Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment. | The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-positive tonsillar cancer have better prognosis than those with HPV-negative tumors, and the former group could hypothetically benefit from reduced, less-toxic treatment without com ... | 2011 | 22038860 |
| human papillomavirus vaccination recommendation may be linked to reimbursement: a survey of virginia family practitioners and gynecologists. | concerns have been raised about gynecologists as vaccinators. this survey evaluated use of the human papillomavirus (hpv) vaccine, attitudes, and barriers among gynecologists and family practitioners for differences between the 2 specialties. | 2011 | 21906978 |
| combined e7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer. | using a uterine cervical cancer cell line expressing human papillomavirus (hpv) 16 e7 antigen and bioluminescent imaging (bli), we evaluated the therapeutic potential of combined immunotherapy using transfected dendritic cells (dc-e7) and human sodium/iodide symporter (hnis) radioiodine gene therapy in a xenograft animal cancer model. dendritic cells expressing either e7 antigen (dc-e7) or no-insert (dc-no insert) were made for immunization materials, and murine uterine cervical cancer cell line ... | 2011 | 22091632 |
| appalachian and non-appalachian pediatricians' encouragement of the human papillomavirus vaccine: implications for health disparities. | background: in medically underserved regions such as appalachia, cervical cancer incidence and mortality are higher than the general u.s. population; therefore, it is important for pediatricians to encourage parents to have their daughters vaccinated against the human papillomavirus (hpv). unfortunately, little is known about the predictors of pediatricians' encouragement of the hpv vaccine among medically underserved populations. the current study compared attitudes and behaviors of pediatricia ... | 2011 | 21907591 |
| [genital human papillomavirus (hpv) infection in women in the province of asti (italy)]. | the aim of this study was to estimate the prevalence of hpv infection in women in the general population and identify associated risk factors. five hundred women participating in a cervical cancer screening program were included in the study which was performed in asti between april 2005 and october 2005. the prevalence of hpv infection was 10.6%. the most common genotypes were types 18, 16, 51 and 31. cigarette smoke and oral contraceptive use were found to be significantly associated with infe ... | 2011 | 22033201 |
| assessment of herd immunity from human papillomavirus vaccination. | 2011 | 22115067 | |
| human papillomavirus infection, vaccination, and cervical cancer communication: the protection dilemma faced by women in southern appalachia. | human papillomavirus is the most frequently occurring sexually transmitted infection and has been recognized as the necessary cause of cervical cancer. understanding the shift in public awareness caused by recent changes to cervical prevention is critical to addressing cervical cancer disparities in appalachia. since the human papillomavirus vaccine was approved for prevention, little data have been collected regarding human papillomavirus risk assessment and vaccine perceptions among appalachia ... | 2011 | 22185292 |
| human papillomavirus genotype prevalence in cervical biopsies from women diagnosed with cervical intraepithelial neoplasia or cervical cancer in fiji. | there is currently limited information about human papillomavirus (hpv) genotype distribution in women in the south pacific region. this study's objective was to determine hpv genotypes present in cervical cancer (cc) and precancers (cervical intraepithelial lesion (cin) 3) in fiji. | 2011 | 21851773 |
| comparative performance of human papillomavirus dna testing using novel sample collection methods. | to explore alternative cervical cancer screening approaches in an underserved population, we compared the performance of human papillomavirus (hpv) dna assays in combination with different sample collection methods for primary cervical screening in the mississippi delta region. three specimens were collected from women aged 26 to 65 years who were either routinely undergoing screening (n = 252) or not (n = 191): clinician-collected cervical specimens, clinician-collected cervicovaginal specimens ... | 2011 | 21998422 |
| binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. | activator protein-1 (ap-1) regulates diverse gene responses triggered by environmental cues and virus-induced cellular stress. although many signaling events leading to ap-1 activation have been described, the fundamental features underlying binding site selection and factor recruitment of dimeric ap-1 complexes to their target genes remain mostly uncharacterized. using recombinant full-length human ap-1 dimers formed between c-jun and fos family members (c-fos, fosb, fra-1, fra-2) for dna bindi ... | 2011 | 21937452 |
| Safety of quadrivalent human papillomavirus vaccine. | 2011 | 22077556 | |
| the impact of anogenital warts on health-related quality of life: a 6-month prospective study. | the burden of anogenital warts will be a determining factor when making decisions about the type of human papillomavirus (hpv) vaccine to be used (bivalent or quadrivalent) and whether to vaccinate males. we conducted a multicenter prospective study to (1) describe the impact of anogenital warts on quality of life and (2) estimate the quality-adjusted life-years (qalys) lost due to anogenital warts. | 2011 | 21934571 |
| clinical performance assessment of five human papillomavirus dna tests using liquid-based cytology samples. | aim: to evaluate the performance of five hpv tests (hybrid capture 2, linear array [la], dna chip, type-specific polymerase chain reaction [pcr], and sequencing) in detecting high-risk (hr) hpv dna and high-grade cervical intraepithelial neoplasia (cin) and cancer. material and methods: a total of 137 women with abnormal cytologies were prospectively enrolled. the diagnostic accuracy of five hpv dna tests in detecting high-grade cin and cancer was assessed, and the concordance among hpv genoty ... | 2011 | 22175246 |
| risk factors for cervical cancer in criminal justice settings. | women in criminal justice settings have an increased prevalence of cervical cancer compared with the general population. however, little is known about abnormal cervical cancer screening results among women in jail and community-based criminal justice settings. thus, the aims of this study were to compare the prevalence of self-reported abnormal papanicolou (pap) test results in women in jail and under community criminal justice supervision and to examine factors associated with abnormal pap tes ... | 2011 | 22004180 |
| human papillomavirus l2 facilitates viral escape from late endosomes via sorting nexin 17. | the human papillomavirus (hpv) l2 capsid protein plays an essential role during the early stages of viral infection, but the molecular mechanisms underlying its mode of action remain obscure. using a proteomic approach, we have identified the adaptor protein, sorting nexin 17 (snx17) as a strong interacting partner of hpv l2. this interaction occurs through a highly conserved snx17 consensus binding motif, which is present in the majority of hpv l2 proteins analysed. using mutants of l2 defectiv ... | 2011 | 22151726 |
| evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. | human papillomavirus-16 (hpv16) is the causative agent in a biologically distinct subset of oropharyngeal squamous cell carcinoma (opscc) with highly favorable prognosis. in clinical trials, hpv16 status is an essential inclusion or stratification parameter, highlighting the importance of accurate testing. | 2011 | 21969383 |
| prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer. | several sexually transmitted infections (sti) have been reported to interact with human papillomavirus (hpv) in the etiology of cervical cancer. a large cohort study is required to obtain a both unbiased and stable estimate of their effects. | 2011 | 21994401 |
| Liquid-based cytology and human papillomavirus testing to screen for cervical cancer: a systematic review for the U.S. Preventive Services Task Force. | Screening programs using conventional cytology have successfully reduced cervical cancer, but newer tests might enhance screening. | 2011 | 22006930 |
| human papillomavirus (hpv) detection and papanicolaou cytology in low-resource women in posadas city, misiones, argentina. | the objective of this study was to determine the prevalence of hpv infection and cervical lesions present in women who attended a health center in a low-resource area of the city of posadas, misiones, argentina. cervical cell samples (n = 163) were processed for papanicolaou cytology and hpv-pcr tests. socio-cultural risk factors were estimated using the odds ratio (or, ci 95 %). cervical lesions were detected in 14.7 % of women. the general prevalence of hpv infection was of 38 %. the most comm ... | 2011 | 22274823 |
| [expression of runx3 in cervical carcinoma and its clinical significance]. | objective to explore the role of runt-related transcription factor 3(runx3) in the tumorgenesis and progression of cervical carcinoma. methods the immunohistochemical staining technique was used to detect the expression of runx3 protein in 25 cases of normal cervix, 34 intraepithelia neoplasia (cin), and 48 cervical carcinomas. sybr greenichimeric fluorescence real-time pcr was applied to detect the expression of runx3 mrna in 10 cases of normal cervix, 24 cin, and 30 cervical carcinomas. result ... | 2011 | 22246363 |
| topical vitamin a treatment of recalcitrant common warts. | abstract: background: common warts (verruca vulgaris) are benign epithelial proliferations associated with human papillomavirus (hpv) infection. salicylic acid and cryotherapy are the most frequent treatments for common warts, but can be painful and cause scarring, and have high failure and recrudescence rates. topical vitamin a has been shown to be a successful treatment of common warts in prior informal studies. case the subject is a healthy, physically-active 30 old female with a 9 year hist ... | 2012 | 22251397 |
| human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories. | objective. to determine the role of human papillomavirus (hpv) status on quality of life (qol) in patients with oral cavity and oropharyngeal squamous cell carcinoma (oscc). since oscc that are associated with high-risk hpv have an improved response to treatment and survival, we hypothesized that patients with these tumors would have better qol trajectories.study design. prospective cohort study.setting. tertiary care academic medical center and 2 affiliated hospitals.subjects and methods. head ... | 2012 | 22275190 |
| human papillomavirus 18 e6 inhibits phosphorylation of p53 expressed in hela cells. | abstract: background: in hpv infected cells p53 function is abrogated by e6 and even ectopically expressed p53 is unable to perform tumor suppressor functions. in addition to facilitating its degradation, e6 may also inhibit p53 transactivity, though the mechanisms are still poorly understood. it has been reported that inhibition of p300, an acetyltransferase responsible for p53 acetylation is inactivated by e6. activation of overexpressed p53 to cause cell growth inhibition is facilitated by i ... | 2012 | 22244155 |
| automated detection of dual p16/ki67 nuclear immunoreactivity in liquid-based pap tests for improved cervical cancer risk stratification. | the papanicolau (pap) test is a routine cytological procedure for early detection of dysplastic lesions in cervical epithelium. a reliable screening method is crucial for triage of women at risk; however manual screening and interpretation are associated with relatively low sensitivity and substantial interobserver diagnostic variability. p16 and ki67 biomarkers have been recently proposed as adjunctive tools in the diagnosis of high-risk human papillomavirus (hrhpv) associated dysplasias to sup ... | 2012 | 22215277 |
| prevalence of human papilloma virus in esophageal carcinomas: a polymerase chain reaction-based study. | objectives: human papilloma virus (hpv) has been repeatedly found in esophageal carcinoma tissues. however, detection rates of hpv dna in these tumors have varied markedly. differences in detection methods, sample types and geographic regions of the sample origin have been suggested as potential causes of this discrepancy. this study was undertaken to analyze the prevalence of hpv in esophageal carcinoma. study design: hpv l1 dna was evaluated in a total of 49 esophageal carcinoma samples, inclu ... | 2012 | 22236750 |
| high-risk human papillomavirus infection in bowen's disease of the nail unit: report of three cases and review of the literature. | background: bowen's disease (bd) of the nail unit is associated with human papillomavirus (hpv) infection. objective: this study aimed to investigate the frequency of high-risk hpv infection, gender, age and digital distribution in this condition. methods: biopsy specimens of 3 consecutive cases with periungual bd were investigated for the presence of hpv dna by in situ hybridization and by polymerase chain reaction (pcr). furthermore, 74 cases of ungual bd conducted with hpv genotyping as repor ... | 2012 | 22269697 |
| incidence of human papillomavirus infection in male sexual partners of women diagnosed with cin ii-iii. | human papillomavirus (hpv) infection is a very common sexually transmitted disease which has been strongly related to cervical cancer and cervical intraepithelial neoplasia (cin), penile cancer and intraepithelial and infiltrating anal squamous cell carcinoma. to describe the hpv status of male sexual partners of women diagnosed with cin ii/iii and to evaluate the practical usefulness of the hpv detection in urine as a reliable marker of genital high-risk hpv infection in men. ninety-one heteros ... | 2012 | 22240393 |
| a new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: immunohistochemical and molecular study and review of the literature. | abstract: background: as a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. in a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (pcsrcc) characterized by prominent endometrial and myometrial involvement, simulating primary endometrial adenocarcinoma with cervical extension. in addition, a review of the literature was made to identify the clinical and pathological features of this rare malignancy. case presentatio ... | 2012 | 22236794 |
| adolescent perceptions of risk and need for safer sexual behaviors after first human papillomavirus vaccination. | to (1) examine perceptions of risk of human papillomavirus (hpv) and other sexually transmitted infections (stis), (2) examine perceived need for safer sexual behaviors, and (3) determine factors associated with less perceived need for safer sexual behaviors, all in the context of receiving the first hpv vaccination. | 2012 | 22213755 |
| the interplay of age stratification and hpv testing on the predictive value of asc-us cytology: results from the athena hpv study. | we have previously shown that human papillomavirus (hpv) genotyping, using the cobas hpv test (roche molecular systems, pleasanton, ca), can be used to identify women with atypical squamous cells of undetermined significance (asc-us) at the highest risk for cervical intraepithelial neoplasia (cin) grade 2 or worse. we investigated the impact of age stratification on the risk of cin 2 or worse in women with asc-us and the performance of hpv genotyping in different age strata. the sensitivity of t ... | 2012 | 22261457 |
| high-risk cutaneous squamous cell carcinoma. | cutaneous squamous cell carcinoma (cscc) is the second most common form of skin cancer and its incidence has increased in recent decades. most csccs are successfully treated by surgery, but local and distant metastases develop in approximately 5% of cases; this proportion is higher in certain forms of cscc with high-risk factors, namely: tumor size >2cm, depth >2mm, clark level ≥iv, perineural invasion, lymphovascular invasion, poor differentiation, certain histologic subtypes (desmoplastic or a ... | 2012 | 22261673 |
| Restriction of human papillomavirus DNA testing in primary cervical screening to women above age 30: systematic review. | Cervical screening with human papillomavirus (HPV) testing is less specific for high-grade cervical intraepithelial neoplasia (=CIN3) than cytology. The aim of this systematic review was to determine whether a restriction of HPV testing to women aged at least 30 years would eliminate the problem. On the basis of the data from randomized controlled trials, we calculated the relative detection of CIN1 and CIN2, and the relative risks of false-positive tests (positive tests without subsequent =CIN3 ... | 2012 | 21968690 |
| A hybrid-capture assay to detect HPV mRNA ratios in cervical specimens. | Human papillomavirus (HPV) DNA screening benefits cervical cancer diagnosis, but a few HPV infections result in cancer. Assays that predict cancer are desirable. A potential biomarker is the ratio of HPV E6-7 over E2 transcripts, which may increase during early cancer progression. Modified hybrid-capture technology detected, in separate wells, HPV E6-7 or E2 mRNA of HPV 16 or HPV 18 in samples. The limit of detection was approximately 1000 copies of in vitro transcribed RNA with linear dynamic r ... | 2012 | 22040847 |
| Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients. | Viral skin infections are commonly present in organ transplant recipients (OTR). In this study, we aimed to identify factors associated with human papillomavirus (HPV) infections in OTR. Patients with solid-organ transplants were recruited from the outpatient nephrology and dermatology clinics in five European countries. Only patients with no current or past skin cancer were included in this analysis. Serum samples were analysed for antibodies to the L1 proteins of 26 cutaneous and two genital H ... | 2012 | 21900419 |
| p53 degradation activity, expression, and subcellular localization of e6 proteins from 29 human papillomavirus genotypes. | human papillomaviruses (hpvs) are the etiological agents of cervical cancer and other human malignancies. hpvs are classified into high- and low-risk genotypes according to their association with cancer. host cell transformation by high-risk hpvs relies in part on the ability of the viral e6 protein to induce the degradation of p53. we report the development of a cellular assay that accurately quantifies the p53 degradation activity of e6 in vivo, based on the fusion of p53 to renilla luciferase ... | 2012 | 22013048 |
| Acceptability of self-collected human papillomavirus specimens as a primary screen for cervical cancer. | The aim of this study was to compare the acceptability of self-collected vs clinician-collected human papillomavirus (HPV) tests. Utilising a cross-sectional approach, 250 non-pregnant, 25-60-year-old women from Leon, Nicaragua self-collected vaginal swabs and brushes for HPV and received a pelvic examination for liquid-based cytology and reflex HPV. Subjects underwent colposcopy, with biopsy if indicated, and completed questionnaires comparing their perceptions of HPV testing methods. Acceptabi ... | 2012 | 22185546 |
| zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. | topical microbicides that block the sexual transmission of hiv and herpes simplex virus 2 (hsv-2) are desperately needed to reduce the incidence of hiv infections worldwide. previously we completed phase 3 testing of the carrageenan-based gel carraguard. although the trial did not show that carraguard is effective in preventing hiv transmission during vaginal sex, it did show that carraguard is safe when used weekly for up to 2 years. moreover, carraguard has in vitro activity against human papi ... | 2012 | 22064530 |
| Compliance with recommended dosing intervals for HPV vaccination among females, 13-17 years, National Immunization Survey-Teen, 2008-2009. | Data from the 2008 and 2009 National Immunization Survey-Teen were analyzed to determine age at initiation of the human papillomavirus vaccine (HPV) series among females 13-17 years (n=7594) and assess compliance with the recommended HPV dosing intervals. Among females who initiated the HPV series, 56.7% of females<13 years at the time of the HPV vaccine recommendation publication did so by age 13; while the majority of females 13-14 and 15-17 years at the time of the recommendation publication ... | 2012 | 22119587 |
| Molecular cloning and characterization of a novel human papillomavirus, HPV 126, isolated from a flat wart-like lesion with intracytoplasmic inclusion bodies and a peculiar distribution of Ki-67 and p53. | Infection with certain human papillomavirus types induces warts with specific macroscopic and microscopic features. We observed multiple flat wart-like lesions on the chest, neck and extremities of an adult T-cell leukemia patient. Histologically, atypical intracytoplasmic inclusion bodies currently known to be pathognomonic for genus gamma or mu papillomaviruses were disclosed in some cells of the epidermis showing histological features compatible with flat warts. In the present study, a novel ... | 2012 | 22056388 |
| what women want. women's preferences for the management of low-grade abnormal cervical screening tests: a systematic review. | if human papillomavirus (hpv) testing will replace cytology in primary cervical screening, the frequency of low-grade abnormal screening tests will double. several available alternatives for the follow-up of low-grade abnormal screening tests have similar outcomes. in this situation, women's preferences have been proposed as a guide for management decisions. | 2012 | 21895959 |
| Comparison of the cobas Human Papillomavirus (HPV) Test with the Hybrid Capture 2 and Linear Array HPV DNA Tests. | The cobas human papillomavirus (HPV) test (cobas) was recently approved by the U.S. Food and Drug Administration (FDA) and identifies HPV16 and HPV18 separately as well as detecting a pool of 11 HR-HPV genotypes (HPV31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -68) and also HPV66. We compared cobas, Linear Array (LA), and Hybrid Capture 2 (HC2) assays for detection of carcinogenic HPV DNA, and cobas and LA for detection of HPV16 and HPV18 DNA, among the first 1,852 women enrolled in the HPV ... | 2012 | 22075592 |
| extraction, purification and characterization of the plant-produced hpv16 subunit vaccine candidate e7 ggg. | several studies indicated that biopharmaceuticals based on the recombinant protein e7 of human papillomavirus (hpv) can serve as therapeutic vaccines preventing the development of cancer in women infected with high-risk types of hpv such as hpv16. here, we report effective extraction and purification of a plant-produced e7ggg-lichenase fusion protein, an hpv16 subunit vaccine candidate, from nicotiana benthamiana plants, to a high yield. the target contains the modified hpv16 e7 protein internal ... | 2012 | 22134037 |
| Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. | Repression of human papillomavirus (HPV) E6 and E7 oncogenes in established cervical carcinoma cell lines causes senescence due to reactivation of cellular tumor suppressor pathways. Here, we determined whether ongoing expression of HPV16 or HPV18 oncogenes is required for the proliferation of primary human cervical carcinoma cells in serum-free conditions at low passage number after isolation from patients. We used an SV40 viral vector expressing the bovine papillomavirus E2 protein to repress ... | 2012 | 22056390 |
| Human Papillomavirus Vaccine Intention Among College Men: What's Oral Sex Got to Do With It? | Abstract Objective: To identify associations between engaging in oral sex and perceived risk of oral cancer among college men. Also, to identify associations, and their moderating factors, between oral sex and human papillomavirus (HPV) vaccine acceptance. Methods: Young men were recruited from 2 university campuses in the South (N = 150). Men completed an audio computer-assisted self-administered interview. Results: With the exception of receiving fellatio, each measure of oral sex behavior ... | 2012 | 22171724 |
| type-specific human papillomavirus infections among young heterosexual male and female sti clinic attendees. | baseline genotype-specific human papillomavirus (hpv) prevalence rates and associated risk factors per gender enable future assessment of the impact of vaccination on hpv dynamics. | 2012 | 22183851 |
| Multiple human papillomavirus infections and type competition in men. | Background. There is little information on multiple human papillomavirus (HPV) infections and the potential for type competition in men, yet competition may impact the type-specific efficacy of HPV vaccination. Methods. Among 2702 uncircumcised men in Kisumu, Kenya, who were seronegative for human immunodeficiency virus, the observed numbers of HPV types detected were compared with the expected number, which was simulated under the assumption of independent infections. To assess the potential fo ... | 2012 | 22058418 |