Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| Promoter methylation analysis of WNT/+¦-catenin signaling pathway regulators to detect adenocarcinoma or its precursor lesion of the cervix. | Cervical adenocarcinoma (AdCA) and adenocarcinoma in situ (ACIS) are frequently missed in cytology-based screening programs. Testing for high-risk human papillomavirus (hrHPV) improves their detection, but novel ACIS/AdCA specific biomarkers are needed to increase specificity for these lesions. Novel markers may be deduced from the WNT/+¦-catenin signaling pathway, which is aberrantly activated during cervical carcinogenesis. | 2011 | 21726894 |
| p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation. | the late phase of the human papillomavirus (hpv) life cycle is linked to epithelial differentiation, and we investigated the factors that regulate this process. one potential regulator is p63, a member of the p53 family of proteins, which modulates epithelial development, as well as proliferation capability, in stem cells. in this study, we examined the role of p63 in the hpv life cycle using a lentiviral knockdown system for p63. in epithelial cells, the δn truncated isoforms of p63 predominate ... | 2011 | 21715473 |
| alaska native adolescent views on cervical cancer, the human papillomavirus (hpv), genital warts and the quadrivalent hpv vaccine. | to understand the knowledge levels, attitudes and perceptions of alaska native adolescent girls about cervical cancer, hpv, genital warts and the hpv vaccine. | 2011 | 21703130 |
| Clustering of human papillomavirus (HPV) types in the male genital tract: the HPV in men (HIM) study. | To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 3677 men from the HPV in Men (HIM) study. | 2011 | 21908729 |
| Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man. | Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squamous papilloma (usually in a central airway). Here we report a unique case of pleomorphic (spindle and squamous cell) carcinoma arising in a mixed glandular and squamous papilloma without human papill ... | 2011 | 21970492 |
| clustering of concordant and discordant cancer types in swedish couples is rare. | spouses are exposed to common environmental cancer risk factors during adulthood. investigating the aggregation of cancer in couples might provide valuable insights into cancer development. | 2011 | 20655736 |
| trends in cervical cancer incidence and mortality in the baltic countries, bulgaria and romania. | the burden of cervical cancer varies considerably in the european union (eu). in this article, we describe trends in incidence of and mortality from this cancer in the two most affected areas: the baltic countries (estonia, latvia and lithuania) and southeast europe (bulgaria and romania). incidence data were obtained from the national cancer registries. data on population and number of deaths from uterine cancers were extracted from the world health organization mortality database. mortality ra ... | 2011 | 20568103 |
| perinatal outcomes in condyloma acuminata pregnancies. | to investigate pregnancy outcome in patients with condyloma acuminata. | 2011 | 20556405 |
| [detection and quantification of human papillomavirus genital infections: virological, epidemiological, and clinical applications]. | human papillomaviruses (hpv) are the main risk factor for cervical cancer. by introducing its dna into the genome of infected human cells, the virus expresses two oncoproteins (e6 and e7) that induce inactivation of tumour suppressors and telomerase. hpv infection is extremely common. but most of women will clear the infection over an 8-10-month period without developing any cervical lesion. in fact, it is the persistence of infection that truly exposes to the risk of cervical cancer. hpv testin ... | 2011 | 20828954 |
| production and purification of human papillomavirus type 33 l1 virus-like particles from spodoptera frugiperda 9 cells using two-step column chromatography. | the major capsid protein l1 of human papillomavirus (hpv) is essential in construction of recombinant antigen vaccines against cervical cancer. hpv type 33 accounts for about 10% of all hpv infections in asia. the gene encoding the major capsid protein l1 of the high-risk hpv type 33 was isolated from a korean patient and expressed in sf-9 insect cells using a baculovirus expression system. hpv33 l1 protein was isolated by two-step chromatographic purification using strong-cation exchange and ce ... | 2011 | 20716445 |
| human papillomavirus and survival in patients with base of tongue cancer. | the incidence of base of tongue cancer is increasing in sweden and the proportion of human papillomavirus (hpv) positive cancer has increased in stockholm, sweden. between 2006 and 2007, 84% of base of tongue cancer cases in stockholm were hpv-positive. the objective of this study was to assess the impact of hpv status on prognosis for base of tongue cancer patients. one-hundred and nine patients were diagnosed with base of tongue cancer between 1998 and 2007 in stockholm county and 95 paraffin- ... | 2011 | 20725995 |
| human papillomavirus infections in laryngeal cancer. | although the association and clinical significance of human papillomavirus (hpv) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of hpv in laryngeal cancer has been inadequately evaluated. herein we review the currently known associations of hpv infections in diseases of the larynx and their potential for oncogenicity. using several methods of detection, hpv dna has been detected in benign (papillomat ... | 2011 | 20848441 |
| triggering of death receptor apoptotic signaling by human papillomavirus 16 e2 protein in cervical cancer cell lines is mediated by interaction with c-flip. | human papillomavirus (hpv) e2 gene disruption is one of the key features of hpv-induced cervical malignant transformation. though it is thought to prevent progression of carcinogenesis, the pro-apoptotic function of e2 protein remains poorly understood. this study shows that expression of hpv16 e2 induces apoptosis both in hpv-positive and -negative cervical cancer cell lines and leads to hyperactivation of caspase-8 and caspase-3. activation of these signaling factors is responsible for the obs ... | 2011 | 20882347 |
| randomized healthservices study of human papillomavirus-based management of low-grade cytological abnormalities. | human papillomavirus (hpv)-based management of women with borderline atypical squamous cells of undetermined significance (ascus) or mildly abnormal cervical intraepithelial neoplasia (cini) cervical cytology has been extensively studied in the research setting. we wished to assess safety and health care resource use of a real-life health care policy using hpv triaging. all 15 outpatient clinics involved in the organized population-based screening program in stockholm, sweden screening program w ... | 2011 | 20824706 |
| squamous cell carcinoma arising from human papillomavirus associated cyst. | 2011 | 20661120 | |
| the acceptability of human papillomavirus vaccine among parents and guardians of newborn to 10-year-old children. | the purpose of our study was to evaluate hpv vaccine acceptance among parents and guardians of children aged 0-10 years. | 2011 | 20709581 |
| low prevalence of hpv in brazilian children with retinoblastoma. | retinoblastoma is the most frequent intra-ocular malignant tumor of the childhood, occurring in 1 of 18,000-30,000 live births. little is known about the causes of sporadic retinoblastoma and only a few authors have investigated the etiologic role of human papillomavirus (hpv), with controversial results. formalin-fixed, paraffin-embedded tissue blocks containing retinoblastoma were retrieved from the archives of the department of pathology at hospital a c camargo, são paulo, brazil. all patient ... | 2011 | 21108347 |
| curcumin suppresses human papillomavirus oncoproteins, restores p53, rb, and ptpn13 proteins and inhibits benzo[a]pyrene-induced upregulation of hpv e7. | curcumin has great potential as a chemopreventive and chemotherapeutic agent; however, its effects on human papillomavirus (hpv)-associated molecular events are inadequately explored. this study examined the effects of curcumin on hpv-associated pathways involved in developing cervical cancer. we demonstrate for the first time that curcumin treatment suppresses cervical cancer cell growth in a three-dimensional raft culture system. curcumin also inhibits tumorigenic characteristics as shown by d ... | 2011 | 21061268 |
| immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments. | epidermolytic ichthyosis (ei) is a skin fragility disorder caused by mutations in genes encoding suprabasal keratins 1 and 10. while the aetiology of ei is known, model systems are needed for pathophysiological studies and development of novel therapies. | 2011 | 20977447 |
| adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine. | the primary objective of this report is to describe the detection of adenocarcinoma in situ (ais) and associated human papillomavirus (hpv) type distribution that was observed in the context of two phase 3 clinical trials of a quadrivalent hpv6/11/16/18 vaccine. in this intention-to-treat analysis, we include all women who had at least one follow-up visit postenrollment. healthy women (17,622) aged 15-26 with no history of hpv disease and a lifetime number of less than five sex partners (average ... | 2011 | 20949623 |
| nk1.1+ cells are important for the development of protective immunity against mhc i-deficient, hpv16-associated tumours. | loss or downregulation of mhc class i molecules on tumour cells is a common mechanism by which tumours can escape t-cell mediated immune responses. in this study, we examined the role of different immune cell lineages in the development of immunity against tumours of the same aetiology but with different mhc class i expression. in vivo depletion of cd8+ cells, but not of cd4+ or nk1.1+ cells in the immunization period resulted in complete elimination of the protective effects of immunization wit ... | 2011 | 21109988 |
| regulation of immune responses to hpv infection and during hpv-directed immunotherapy. | the recent development of vaccines prophylactic against human papillomavirus (hpv) infection has the potential to reduce the incidence of cervical cancer globally by up to 70% over the next 40 years, if universal immunization is adopted. as these prophylactic vaccines do not alter the natural history of established hpv infection, immunotherapies to treat persistent hpv infection and associated precancers would be of benefit to assist with cervical cancer control. efforts to develop immuno-therap ... | 2011 | 21198666 |
| quadrivalent human papillomavirus (hpv) vaccine: a review of safety, efficacy, and pharmacoeconomics. | what is known and background: the introduction of vaccines has lead to a significant reduction in morbidity and mortality from diseases such as measles, rubella and poliomyelitis, as well as the eradication of smallpox (ertl hc, xiang z (1996) the journal of immunology, 156, 3579-3582). a recent vaccine approved by the food and drug administration (fda) is the recombinant quadrivalent human papillomavirus (hpv) vaccine (merck, gardasil®). concerns raised with this preventive measure include safe ... | 2011 | 21198715 |
| preclinical development of highly effective and safe dna vaccines directed against hpv 16 e6 and e7. | to allow vaccination irrespective of hla type, dna vaccines encoding full-length antigens are required. however, here, we demonstrate that the immunogenicity of dna vaccines encoding the full-length human papillomavirus (hpv) type 16 e7 and e6 proteins is highly reduced compared to vaccines encoding only the immunodominant epitope. furthermore, the low remaining immunogenicity is essentially lost for both e7 and e6 when a nononcogenic "gene-shuffled" variant is utilized. to address these issues, ... | 2011 | 21207427 |
| human papillomavirus in brazilian women with and without cervical lesions. | human papillomavirus (hpv) high-risk (hr) types are the causal factor for cervical cancer and premalignant dysplasia. data on frequency of hpv types provide a basis to design and evaluate hpv prevention programs. taking into account the heterogeneity of hpv types across and within populations this study aims to access the hpv frequency in brazilian women. | 2011 | 21208414 |
| long-term persistence of human papillomavirus in environments. | the possibility of its indirect transmission of human papillomavirus (hpv) via formites has been widely raised but with no biological proof. this study explored the durability of hpv16 pseudoviruses and native viruses in different environmental contamination scenarios. | 2011 | 21208649 |
| human papillomavirus infection in honduran women with cervical intraepithelial neoplasia or cervical cancer. | the aims of this study were to investigate human papillomavirus (hpv) genotypes in women with cervical intraepithelial lesions and cervical cancer (cc) in honduras and to identify epidemiological cofactors that contribute to the development of cc. | 2011 | 21192177 |
| detection of human papillomavirus in bronchoalveolar lavage samples in immunocompetent children. | human papillomavirus (hpv) has been detected in lungs of adults and has been proposed to play a role in lung carcinogenesis. however, no data are currently available on the incidence of hpv in the lower respiratory tract of children. | 2011 | 21178656 |
| retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the e7 oncoprotein in hpv 16-positive cells. | "high risk" human papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. in these tumors, the physical integration of the hpv genome is a frequent, though not invariable occurrence, but the constitutive expression of the e6 and e7 viral genes is always observed, suggesting key roles for the e6 and e7 oncoproteins in the process of malignant transformation. the "intracellular antibody" technology using recombinant antibodies in single-chain forma ... | 2011 | 21241471 |
| single-tube multiplex pcr using type-specific e6/e7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia. | 2011 | 21241508 | |
| detection of human papillomavirus in multiple eccrine poromas in a patient with chronic graft-vs-host disease and immunosuppression. | 2011 | 21242407 | |
| development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. | we found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (hpv) genomes replicate readily when delivered into u2os cells by electroporation. the replication efficiency is dependent on the amount of input hpv dna and can be followed for more than 3 weeks in proliferating cell culture without selection. cotransfection of recircularized hpv genomes with a linear g418 resistance marker plasmid has allowed subclonin ... | 2011 | 21248030 |
| prevalence and type distribution of human papillomavirus in healthy japanese women aged 20 to 25 years old enrolled in a clinical study. | efficacy, immunogenicity and tolerability of the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine were evaluated in japanese women aged 20-25 years, for which results have been reported previously. we analyzed the baseline data from that study and report the prevalence rates of hpv infection in young healthy japanese women. one thousand and the forty japanese women aged 20-25 years were enrolled in a phase ii, double-blind, controlled, randomized, multicenter study. at study entry, cervi ... | 2011 | 21251162 |
| cd40 is overexpressed by hpv16/18-e6 positive cervical carcinoma and correlated with clinical parameters and vascular density. | cd40 is expressed in many tumor cells, however, its role in tumor biology is yet to be demonstrated. in the present study, we investigated the role of cd40 in cervical carcinoma. in vivo, we evaluated cd40 expression in 56 cervical carcinoma tissues, 43 cervicitis and 38 normal cervix, and investigated the relationship between cd40 and hpv antigen, histopathological parameters, vascular density, and vascular endothelial growth factor (vegf) expressions. the results clearly demonstrated that cd40 ... | 2011 | 21251894 |
| estimating the impact of human papillomavirus (hpv) vaccination on hpv prevalence and cervical cancer incidence in mali. | human papillomavirus vaccines have potential to reduce cervical cancer incidence and mortality; however, cultural and economic barriers may hinder success in developing countries. we assessed impact of a single vaccine campaign in mali with use of mathematical modeling. our model shows that decreases in the prevalence of human papillomavirus infection are proportional to achieved vaccination coverage. | 2011 | 21252142 |
| a human papillomavirus 8 e7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions. | we investigated the potential of nicotiana benthamiana to express the e7 protein of human papillomavirus 8 (hpv-8), a paradigm genotype among cutaneous hpvs. the protein, modified in its putative prb-binding domain (e7(qgd)), was transiently expressed in leaves following infiltration with agrobacteria carrying either a binary vector combined with silencing suppressor constructs or replicating tobacco mosaic virus (tmv)-based vectors with different targeting signals. hpv-8 e7(qgd) yields ranged f ... | 2011 | 21234770 |
| diagnosis of anal human papillomavirus infection: polymerase chain reaction or cytology? | to investigate the relationship between human immunodeficiency virus (hiv)-positive and hiv-negative patients engaging in promiscuous behaviors and anal human papillomavirus (hpv) infection diagnosed by polymerase chain reaction (pcr) and cytology. | 2011 | 21239202 |
| molecular pathogenesis of cervical cancer. | cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (hpv). oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. vaccination against hpv prevents the acquisition of cervical dysplastic lesions among eligible women who ... | 2011 | 21239888 |
| recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination. | the authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (rlp) due to human papillomavirus (hpv) type 11, who required frequent surgical treatment. complete recovery occurred after hpv vaccination (gardasil). confirmed remission of rlp has continued during the 17 months of follow-up since vaccination. the authors conclude that hpv vaccination may represent a new therapeutic option in this situation. | 2011 | 21220258 |
| population-based frequency assessment of hpv-induced lesions in patients with borderline pap tests in the emilia-romagna region: the pater study. | the pater study assessed the frequency of high-risk (hr) and low-risk (lr) human papillomavirus (hpv) in hpv-induced lesions in patients with borderline cytology. | 2011 | 21222568 |
| molecular characterization of late stomal recurrence following total laryngectomy. | the goal was to determine recurrent or second primary status for late stomal malignancies, 16 and 17 years post-total laryngectomy in two laryngeal squamous cell carcinoma (lscc) patients, based on dna methylation signatures and hpv typing. adopting a literature review based definition of late stomal recurrences as new primaries at the site of the stoma or neopharynx occurring >5 years after total laryngectomy, we employed a multi-gene candidate approach to examine promoter methylation in 24 tum ... | 2011 | 21225233 |
| identification of differential expressed transcripts in cervical cancer of mexican patients. | the aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (cin) 1, cin 2, cin 3, and microinvasive cancer by suppression subtractive hybridization and southern blotting. after analyzing 1,800 cdna clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). these results were validated by northern blot analysis (p = 0.0001) in the identification of 28 overe ... | 2011 | 21225484 |
| cutaneous human papillomavirus-related immune reconstitution-associated disease in human immunodeficiency virus: an under-recognized phenomenon. | 2011 | 21039411 | |
| procedural and temporal compliance to cervical cancer screening guidelines in a cdc-funded program in alaska. | to estimate changes in clinical practice in a cervical cancer screening program after the american society for colposcopy and cervical pathology's issuance of 2006 consensus guidelines (2006cg) for managing abnormal pap tests. | 2011 | 21169865 |
| association of human papillomavirus-related knowledge, attitudes, and beliefs with hiv status: a national study of gay men. | anal cancer and other diseases caused by human papillomavirus (hpv) are more common among people who are hiv-positive. to understand the potential role of hiv status in hpv prevention efforts, we examined hpv-related knowledge, attitudes, and beliefs among hiv-positive and hiv-negative gay men. | 2011 | 21169868 |
| human papillomavirus vaccine: now for boys too? | 2011 | 21157346 | |
| chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification. | chlamydiae are gram negative, obligate intracellular bacteria, and chlamydia trachomatis is the etiologic agent of the most commonly reported sexually transmitted disease in the united states. chlamydiae undergo a biphasic life cycle that takes place inside a parasitophorous vacuole termed an inclusion. chlamydial infections have been epidemiologically linked to cervical cancer in patients previously infected by human papillomavirus (hpv). the inclusion associates very closely with host cell cen ... | 2011 | 21477082 |
| what constitutes consent when parents and daughters have different views about having the hpv vaccine: qualitative interviews with stakeholders. | objective the uk human papillomavirus (hpv) vaccine programme commenced in the autumn of 2008 for year 8 (age 12-13 years) schoolgirls. we examine whether the vaccine should be given when there is a difference of opinion between daughters and parents or guardians. design qualitative study using semi-structured interviews. participants a sample of 25 stakeholders: 14 professionals involved in the development of the hpv vaccination programme and 11 professionals involved in its implementati ... | 2011 | 21478419 |
| persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. | human papillomavirus (hpv) persistence is the pivotal event in cervical carcinogenesis. we followed a large-scale community-based cohort for 16 years to investigate the role of genotype-specific hpv persistence in predicting cervical cancer including invasive and in situ carcinoma. | 2011 | 21900119 |
| Codon usage roles in human papillomavirus. | Human papillomavirus (HPV) genomes, similar to other virus genomes, frequently have a G + C content significantly different from their host species. The HPV genomes show a strong codon usage bias to 18 codons, with 14 showing T at the third position amongst degenerately encoded amino acids. The codon usage pattern in HPV genome plays an important role, which regulates low or non-translational expression of the viral capsid genes and results in very weak protein expression of oncogenes in a wide ... | 2011 | 22025363 |
| the role of the human papillomavirus in oropharyngeal cancer. | in recent years there has been an overall decrease in cancers of the oral cavity, and a concurrent increase in cancers in specific sites of the posterior oral cavity and oropharynx in the united states. there is increasing evidence that the human papillomavirus may play a role in the development of oropharyngeal squamous cell carcinoma. in this article we review the biology and risk factors associated with hpv and oropharyngeal carcinoma, and recent data suggesting that this type of cancer may b ... | 2011 | 22013861 |
| [immunohistochemical staining of p16 in squamous cell carcinomas of the genital and extragenital area]. | positive immunostaining for the tumor suppressor protein p16 is associated with the presence of mucosal or αsubtypes of human papillomavirus (hpv) in cervical and genital squamous cell carcinoma (scc). the aim of this study was to determine whether p16 immunostaining is also associated with mucosal hpv in extragenital scc. | 2011 | 21944770 |
| another look at the human papillomavirus vaccine experience in canada. | policy debates about immunization frequently focus on classic trade-offs between individual versus collective well-being. publicly funded immunization programs are usually justified on the basis of widespread public benefit with minimal individual risk. we discuss the example of the policy process surrounding the adoption of the human papillomavirus (hpv) vaccine in canada to consider whether public good arguments continue to dominate immunization policymaking. specifically, we show how a range ... | 2011 | 21852642 |
| distribution of hpv genotypes in cervical intraepithelial lesions and cervical cancer in tanzanian women. | abstract: | 2011 | 22081870 |
| Visual inspection methods for cervical cancer prevention. | The need for simple, cost-effective screening approaches for cervical cancer prevention in low-resource countries has led to the evaluation of visual screening with 3-5% acetic acid. The low reproducibility and wide variation in accuracy reflect the subjective nature of the test. Pooled sensitivity, specificity, positive and negative predictive values were 80%, 92%, 10% and 99%, respectively, for detecting cervical intraepithelial neoplasia grade 2 or worse lesions. Realistic sensitivity of a qu ... | 2011 | 22075441 |
| Treatment of HPV with hypnosis--psychodynamic considerations of psychoneuroimmunology: a brief communication. | There is increasing evidence that the hypnotic cure of warts (infection by the human papilloma virus or HPV) results from activation of an immune response, but whether this is cellular or systemic is unknown. The hypnosis can be by direct suggestion or analytical hypnotherapy when indicated. The evidence is reviewed, and 4 clinical cases suggesting cellular immune response are presented. | 2011 | 21867375 |
| [the incidence of human papilloma virus associated vulvar cancer in younger women is increasing and wide local excision with sentinel lymph node biopsie has become standard]. | sentinel lymph node (sln) dissections have been shown to be sensitive for the evaluation of nodal basins for metastatic disease and are associated with decreased short-term and long-term morbidity when compared with complete lymph node dissection. there has been increasing interest in the use of sln technology in gynecologic cancers. this review assesses the current evidence-based literature for the use of sln dissections in gynecologic malignancies. | 2011 | 21968892 |
| Bacterial vaginosis and the natural history of human papillomavirus. | To evaluate associations between common vaginal infections and human papillomavirus (HPV). | 2011 | 21869857 |
| biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response? | human papillomavirus (hpv) infection is the cause of cervical cancer. increased production of reactive oxygen species (ros) maybe the common mechanism through which hpv-cofactors (i.e., smoking and inflammation) influence duration of infections. biomarkers of total oxidant load may serve as cumulative measures of ros exposure due to these cofactors. therefore, we conducted a study evaluating the association between biomarkers of oxidant load and duration of hpv infections, early hpv natural hist ... | 2011 | 21858808 |
| Usefulness of CINtec® PLUS p16/Ki-67 double-staining in cytological screening of cervical cancer. | This study evaluated the usefulness of p16(INK4a)/Ki-67 as a new biomarker in the diagnosis of human papillomavirus (HPV)-related cervical lesions. | 2011 | 21986167 |
| Feasibility of self-sampling and human papillomavirus testing for cervical cancer screening in First Nation women from Northwest Ontario, Canada: a pilot study. | Background The incidence of cervical cancer is up to sixfold higher among First Nation women in Canada than in the general population. This is probably due to lower participation rates in cervical cancer prevention programmes. Objective To raise screening participation in this underserved population by launching an alternative approach to (Pap)anicolaou testing in a clinic-namely, vaginal self-sampling followed by human papillomavirus (HPV) diagnostics. Methods Good relationships were establis ... | 2011 | 22021733 |
| project genesis: self-reported religiosity and spirituality and sexual risk-taking in young african-american women attending a historically african-american college. | this pilot study explored the relationship between self-reported religiosity, spirituality, and sexual risk-taking. the participants were a convenience sample of (n = 100) female students attending a historically african-american college (hbcu) in the south. on this predominantly female campus, students completed an anonymous health-risk survey, plus additional items, to measure their religiosity and spirituality. correlation analysis revealed that although these students reported a high degree ... | 2011 | 21888148 |
| human papillomavirus genotypes in iranian patients with cervical cancer. | the aim of this study was to determine the frequency of hpv genotypes isolated from cervical intra-epithelial neoplasia grade iii and invasive carcinomas of iranian patients. a total of 94 cases were selected in five years from 2003 to 2007. after nucleic acid purification, real-time pcr was performed by means of gp5+/gp6+ primers. subsequently, pcr products were sequenced, on the basis of which a phylogenetic tree was constructed. negative samples and twelve randomly selected positive samples w ... | 2011 | 22041132 |
| Tuberculosis and Oncogenic HPV: Potential Co-infections in Women at High-risk of Cervical Cancer in Rural China. | The study was embedded in Shanxi Province Cervical Cancer Screening Study II with the aim of examining the association between history of diagnosed tuberculosis or cervical inflammation and oncogenic human papillomavirus (HPV) infection, persistent oncogenic HPV infection, cervical intraepithelial neoplasia grade 3 or cervical cancer (CIN3+) in an isolated rural population of China. A total of 8,798 women were recruited for cervical cancer screening and an interviewer-administered questionnaire. ... | 2011 | 22126473 |
| Epidemiology and burden of HPV infection and related diseases: implications for prevention strategies. | Human papillomavirus (HPV) infection is a necessary, although not sufficient cause of cervical cancer. Globally, HPV infection accounts for an estimated 530,000 cervical cancer cases (~270,000 deaths) annually, with the majority (86% of cases, 88% of deaths) occurring in developing countries. Approximately 90% of anal cancers and a smaller subset (<50%) of other cancers (oropharyngeal, penile, vaginal, vulvar) are also attributed to HPV. In total, HPV accounts for 5.2% of the worldwide cancer bu ... | 2011 | 21962466 |
| Human papillomavirus in vaginal intraepithelial neoplasia. | There are limited data on the prevalence and distribution of human papillomavirus (HPV) genotypes in vaginal intraepithelial neoplasia (VAIN). We sought to clarify this issue in a series of 450 VAIN cases with a confirmed diagnosis between 1990 and 2006. HPV genotyping was performed using paraffin-embedded specimens and polymerase chain reaction (PCR)-based methods. Multiple HPV types were validated by E6 type-specific PCR and direct sequencing. The HPV genotypes of the vaginal and cervical neop ... | 2011 | 22095387 |
| Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru. | Few data exist on oral human papillomavirus (HPV) prevalence in female sex workers (FSWs). Information regarding oral sex practices of 185 Peruvian FSWs, 18-26 years of age, was obtained via survey and compared with HPV testing results of oral rinse samples. Oral HPV prevalence was 14/185 (7.6%); four (28.9%) HPV genotypes were carcinogenic. One hundred and eighty-two participants reported having had oral sex; 95% reported condom use during oral sex with clients and 9.5% with partners. Women who ... | 2011 | 22096051 |
| Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin. | Cervical carcinoma is one of the most common cancers in women worldwide. It is well established that chronic infection of the genital tract by various mucosatropic human papillomavirus (HPV) types causes cervical cancer. Cellular immunity to E7 protein from HPV (HPVE7) has been associated with clinical and cytologic resolution of HPV-induced lesions. Thus, we decided to test if targeting of HPVE7 to dendritic cells using a fusion protein containing the extra domain A (EDA) from fibronectin, a na ... | 2011 | 21898393 |
| [Detection of human papillomavirus in gingival fluid of Venezuelan HIV patients with periodontal disease]. | Evidence suggests that viruses may be involved in the activation of periodontal disease, allowing the overgrowth of periodontal pathogens. The purpose of the present study was to detect the presence of Human Papillomavirus (HPV) in gingival crevicular fluid (GCF) in HIV+ Venezuelan patients with periodontal disease. We evaluated GCF samples from 20 HIV+ patients with periodontal disease from the Infectious Disease Center, Faculty of Dentistry, Central University of Venezuela, and were clinically ... | 2011 | 21950192 |
| diagnostic implications of l1, p16, and ki-67 proteins and hpv dna in low-grade cervical intraepithelial neoplasia. | the expressions of p16, ki-67, and l1 proteins and human papillomavirus dna were investigated using polymerase chain reaction (hpv/pcr) and catalyzed signal-amplified colorimetric dna in situ hybridization (csac/ish) as potential molecular markers for the diagnosis and transforming potential of low cervical intraepithelial neoplasia (cin1). ki-67 and p16 protein expression increased linearly from control cases to more dysplastic cases (cin1, cin2, and cin3), peaking in squamous cell carcinoma ca ... | 2011 | 21979598 |
| sexually transmitted diseases in men who have sex with men. | men who have sex with men (msm) have increased rates of human immunodeficiency virus (hiv) infection and sexually transmitted diseases (stds) compared with demographically matched controls. the reasons for the disproportionate infection burden are complex, including biological, behavioral, and sociocultural factors. hiv and syphilis may often be coprevalent among msm. the use of nucleic acid amplification testing has enhanced the ability to detect frequently asymptomatic gonococcal and chlamydia ... | 2011 | 22080272 |
| extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. | background: extracapsular spread (ecs) is commonly used to justify adjuvant chemotherapy in patients with head and neck cancer. the role of ecs as a prognosticator and adjuvant therapy determinant in surgically resected, human papillomavirus-related oropharyngeal squamous cell carcinoma (opscc), however, has never been determined. methods: of 210 oropharynx patients in a prospective transoral laser microsurgery database, 152 patients who had p16-positive primary opscc and pathologically positive ... | 2011 | 22086669 |
| high-risk hpv infection after five years in a population-based cohort of chilean women. | abstract: background: the need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (hpv): vaccines and screening tests. to consider these innovations, information on hpv type distribution and natural history is necessary. this is a five-year follow-up study of gynecological high-risk (hr) hpv infection among a chilean population-based cohort of women. findings: a population-based random sample of 969 women ... | 2011 | 22087645 |
| squamous cell carcinoma of the scalp associated with human papillomavirus type 16. | 2011 | 21896422 | |
| comparison of the immunogenicity of the human papillomavirus (hpv)-16/18 vaccine and the hpv-6/11/16/18 vaccine for oncogenic non-vaccine types hpv-31 and hpv-45 in healthy women aged 18-45 years. | protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (hpv) vaccines may provide a significant medical benefit. available clinical efficacy data suggest the two licensed vaccines (hpv-16/18 vaccine, glaxosmithkline biologicals [gsk], and hpv-6/11/16/18 vaccine, merck & co., inc.) differ in terms of protection against oncogenic non-vaccine hpv types -31/45. the immune responses induced by the two vaccines against these two non-vaccine hpv types (cross-r ... | 2011 | 22048172 |
| screening still the "best buy" for tackling cervical cancer. | 2011 | 21897481 | |
| vaccine-preventable diseases and their impact on latin american children. | a joint meeting of the latin american society of pediatric infectious diseases, the dominican society of pediatrics and the dominican society of vaccinology was held in the dominican republic. this report highlights the most relevant issues that were presented and discussed about vaccine-preventable diseases, their epidemiology and impact in latin american children, the need to move forward and expand national immunization programs and the economical and political obstacles to introduce ?new? va ... | 2011 | 22085169 |
| expanding the clinical and genetic spectrum of human cd40l deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in brazilian patients. | cd40 ligand (cd40l) deficiency or x-linked hyper-igm syndrome (x-higm) is a well-described primary immunodeficiency in which pneumocystis jiroveci pneumonia is a common clinical feature. we have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 x-higm patients from nine unrelated brazilian families. among these, we describe the first case of paracoccidioidomycosis (pcm) in x-higm. the molecular genetic analysis of cd40l was perform ... | 2011 | 22193914 |
| proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent hpv16/18 vaccine. | three-dose regimens for human papillomavirus (hpv) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest. | 2011 | 21908768 |
| evidence for alteration of ezh2, bmi1, and kdm6a and epigenetic reprogramming in human papillomavirus type 16 e6/e7-expressing keratinocytes. | a number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (hpv)-associated carcinogenesis, and investigations of such alterations, including changes in chromatin proteins and histone modifications, have the potential to lead to therapeutic epigenetic reversion. we report here that transformed hpv16 e6/e7-expressing primary human foreskin keratinocytes (hfks) (e6/e7 cells) demonstrate increased expression of the prc2 methyltransferase ezh2 at ... | 2011 | 21865393 |
| [human papilloma virus and lymphatic metastasis in squamous cell carcinoma of the cervix]. | our study included 112 patients with squamous cell cervical carcinoma la-lib stages (figo). all of them were restaged on the basis of histological evidence after surgical treatment. ninety-eight were staged at final analysis. human papilloma virus (hpv) was detected in endocervical smears and paraffin blocks of lymph nodes by pcr and real-time pcr. oncogenic hpv in primary tumor was detected in 86 (87.8%); two or more genotypes--65 (75.58%): still more--21 (24.4%). in the latter group, the frequ ... | 2011 | 21882602 |
| intracervical procedures and the risk of subsequent very preterm birth: a case-control study. | objective. to investigate the relation of prior intracervical procedures with very preterm birth. design. a population-based case-control study. setting. the study was conducted in australia between 2002 and 2004. sample. 345 women having a medically indicated and 236 having a spontaneous singleton birth between 20 and 31 weeks of gestation and 796 women selected randomly from all giving birth at 37 or more weeks of gestation. methods. interview data were analysed using logistic regression. outc ... | 2011 | 22085381 |
| efficacy of a bivalent hpv 16/18 vaccine against anal hpv 16/18 infection among young women: a nested analysis within the costa rica vaccine trial. | anal cancer remains rare (incidence of about 1·5 per 100,000 women yearly), but rates are increasing in many countries. human papillomavirus (hpv) 16 and 18 infections cause most cases of anal cancer. we assessed efficacy of an as04-adjuvanted hpv 16 and hpv 18 vaccine against anal infection with hpv 16, hpv 18, or both (hpv 16/18). | 2011 | 21865087 |
| molecular changes in the multistage pathogenesis of head and neck cancer. | head and neck squamous cell carcinomas (scchn) arise in the mucosa of the upper aerodigestive tract at multiple anatomic sites. while tobacco and alcohol exposure remain the primary risk factors for this malignancy, infection with the human papilloma virus is emerging as a major contributing factor to cancers that arise primarily in the oropharynx. despite therapeutic advances, survival has remained relatively unchanged over the past few decades. increased understand of the cellular and molecula ... | 2011 | 22112483 |
| Comparison of the INNO-LiPA and PapType assays for detection of human papillomavirus in archival vulva dysplasia and/or neoplasia tissue biopsy specimens. | INNO-LiPA and PapType human papillomavirus (HPV) genotyping assays were compared for detection of HPV genotypes on archival vulvar tissue. The INNO-LiPA assay detected 49 HPV-16 infections, compared with 47 detected by the PapType assay. The INNO-LiPA assay detected amplifiable DNA in 59 (91%) biopsy specimens, compared with 57 (88%) specimens for which amplifiable DNA was detected by the PapType assay. The two genotyping assays were highly comparable. | 2011 | 21940480 |
| comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model. | to compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (hpv) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to hpv types 6 and 11, and reported long term immunogenicity. | 2011 | 21951758 |
| Loss of the a2ß1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. | Expression of the a2ß1 integrin, a receptor for collagens and laminin, is altered during tumor progression. Recent studies have linked polymorphisms in the a2 integrin gene with oral, squamous cell carcinoma (SCC). To determine the a2ß1 integrin's role in SCC progression, we crossed a2-null mice with K14-HPV16 transgenic animals. Pathological progression to invasive carcinoma was evaluated in HPV-positive, a2-null (HPV/KO) and HPV-positive, wild-type (HPV/WT) animals. a2ß1 integrin expression st ... | 2011 | 22046385 |
| Incorporating Calibrated Model Parameters into Sensitivity Analyses: Deterministic and Probabilistic Approaches. | Objective: The aim of this study was to examine how calibration uncertainty affects the overall uncertainty of a mathematical model and to evaluate potential drivers of calibration uncertainty. Methods: A lifetime Markov model of the natural history of human papillomavirus (HPV) infection and cervical disease was developed to assess the cost effectiveness of a hypothetical HPV vaccine. Published data on cervical cancer incidence and mortality and prevalence of pre-cursor lesions were used as end ... | 2011 | 22149631 |
| cervical cancer in the screening era: who fell victim in spite of successful screening programs? | to compare profiles of a prescreening and screening cohort of women with cervical cancer regarding histopathology and clinical variables in order to identify those remaining at risk despite successful screening programs. by analyzing these profiles we hope to improve future screening methods. | 2011 | 21860732 |
| The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region. | The human papillomavirus type 16 (HPV-16) E5 oncoprotein is embedded in membranes of the endoplasmic reticulum and nuclear envelope with its C terminus exposed to the cytoplasm. Among other activities, E5 cooperates with the HPV E6 oncoprotein to induce koilocytosis in human cervical cells and keratinocytes in vitro. The effect of E5 on infected cells may rely on its interactions with various cellular proteins. In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-b ... | 2011 | 21849434 |
| human papillomavirus type-specific prevalence in women with cervical intraepithelial neoplasm in western china. | hpv type-specific prevalence was studied in 600 cases of cervical intraepithelial neoplasm in western china by genoarray test. hpv 16 and 58 were the most prevalent types with the prevalence of 37.8% or 21.8% respectively. hpv 18 or 45 was uncommon type. the result shows different type distributions from that of other regions, which is important evidence for the selection of future genotypes in hpv vaccines in western china. | 2011 | 22170939 |
| Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes. | ABSTRACT: BACKGROUND: The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR). Viral gene expression may be regulated through epigenetic mechanisms, including cytosine methylation at CpG dinucleotides. We have analyzed the distribution of CpG sites and CpG islands/clusters (CGI) among 92 different HPV genomes grouped in function of their preferential tropism: cutaneous or mucosal. We calculated t ... | 2011 | 22118413 |
| [results of the first human papilloma virus center in hungary (2007-2011)]. | human papilloma virus (hpv) is the most common sexually transmitted infection in the 21st century. it has been established that infections with specific hpv types are contributing factors to cervical cancer. approximately 99.7% of cervical cancers are associated with high risk hpv types. hpv testing plays an important role in the prevention, by decreasing the prevalence and the mortality of cervical cancer. there are 16 hpv-centers operating in hungary, in which patients undergo hpv screening, c ... | 2011 | 22011366 |
| Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment. | The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-positive tonsillar cancer have better prognosis than those with HPV-negative tumors, and the former group could hypothetically benefit from reduced, less-toxic treatment without com ... | 2011 | 22038860 |
| human papillomavirus vaccination recommendation may be linked to reimbursement: a survey of virginia family practitioners and gynecologists. | concerns have been raised about gynecologists as vaccinators. this survey evaluated use of the human papillomavirus (hpv) vaccine, attitudes, and barriers among gynecologists and family practitioners for differences between the 2 specialties. | 2011 | 21906978 |
| combined e7-dendritic cell-based immunotherapy and human sodium/iodide symporter radioiodine gene therapy with monitoring of antitumor effects by bioluminescent imaging in a mouse model of uterine cervical cancer. | using a uterine cervical cancer cell line expressing human papillomavirus (hpv) 16 e7 antigen and bioluminescent imaging (bli), we evaluated the therapeutic potential of combined immunotherapy using transfected dendritic cells (dc-e7) and human sodium/iodide symporter (hnis) radioiodine gene therapy in a xenograft animal cancer model. dendritic cells expressing either e7 antigen (dc-e7) or no-insert (dc-no insert) were made for immunization materials, and murine uterine cervical cancer cell line ... | 2011 | 22091632 |
| appalachian and non-appalachian pediatricians' encouragement of the human papillomavirus vaccine: implications for health disparities. | background: in medically underserved regions such as appalachia, cervical cancer incidence and mortality are higher than the general u.s. population; therefore, it is important for pediatricians to encourage parents to have their daughters vaccinated against the human papillomavirus (hpv). unfortunately, little is known about the predictors of pediatricians' encouragement of the hpv vaccine among medically underserved populations. the current study compared attitudes and behaviors of pediatricia ... | 2011 | 21907591 |
| [genital human papillomavirus (hpv) infection in women in the province of asti (italy)]. | the aim of this study was to estimate the prevalence of hpv infection in women in the general population and identify associated risk factors. five hundred women participating in a cervical cancer screening program were included in the study which was performed in asti between april 2005 and october 2005. the prevalence of hpv infection was 10.6%. the most common genotypes were types 18, 16, 51 and 31. cigarette smoke and oral contraceptive use were found to be significantly associated with infe ... | 2011 | 22033201 |
| assessment of herd immunity from human papillomavirus vaccination. | 2011 | 22115067 | |
| human papillomavirus infection, vaccination, and cervical cancer communication: the protection dilemma faced by women in southern appalachia. | human papillomavirus is the most frequently occurring sexually transmitted infection and has been recognized as the necessary cause of cervical cancer. understanding the shift in public awareness caused by recent changes to cervical prevention is critical to addressing cervical cancer disparities in appalachia. since the human papillomavirus vaccine was approved for prevention, little data have been collected regarding human papillomavirus risk assessment and vaccine perceptions among appalachia ... | 2011 | 22185292 |