Publications

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non-cholera vibrios: the microbial barometer of climate change.there is a growing interest in the role of climate change in driving the spread of waterborne infectious diseases, such as those caused by bacterial pathogens. one particular group of pathogenic bacteria - vibrios - are a globally important cause of diseases in humans and aquatic animals. these gram-negative bacteria, including the species vibrio vulnificus, vibrio parahaemolyticus and vibrio cholerae, grow in warm, low-salinity waters, and their abundance in the natural environment mirrors ambi ...201727843109
molecular identification and functional delineation of a glutathione reductase homolog from disk abalone (haliotis discus discus): insights as a potent player in host antioxidant defense.glutathione reductase (gsr) is an enzyme that catalyzes the biochemical conversion of oxidized glutathione (gssg) into the reduced form (gsh). since the ratio between the two forms of glutathione (gsh/gssg) is important for the optimal function of gsh to act as an antioxidant against h2o2, the contribution of gsr as an enzymatic regulatory agent to maintain the proper ratio is essential. abalones are marine mollusks that frequently encounter environmental factors that can trigger the overproduct ...201727919756
tc38, a teleost tfpi-2 peptide that kills bacteria via penetration of the cell membrane and interaction with nucleic acids.tissue factor pathway inhibitor 2 (tfpi-2) is an analog of tfpi-1 and a potent endogenous inhibitor of tissue factor (tf)-mediated blood coagulation. recent reports have proven that the c-terminal of tfpi-2 peptides in humans and several other vertebrates possesses antibacterial activity against gram-positive and gram-negative bacteria. in our previous study, we reported that the tfpi-2 peptide, tc38 in tongue sole (cynoglossus semilaevis) was active against micrococcus luteus. in this study, we ...201728263880
identification and function analysis of an anti-lipopolysaccharide factor from the ridgetail prawn exopalaemon carinicauda.anti-lipopolysaccharide factor is a kind of antimicrobial peptide (amp) with broad-spectrum activities against bacteria, virus, and fungi in crustacean. different isoforms of alfs showed different activities to virus or bacteria. therefore, discovery of more alfs will provide new insights into drug development and disease control. here we reported an alf gene, ecalf1, isolated from the ridgetail prawn exopalaemon carinicauda. its transcripts was mainly detected in hemocytes. silencing of ecalf1 ...201728082184
mechanisms for pseudoalteromonas piscicida-induced killing of vibrios and other bacterial pathogens.pseudoalteromonas piscicida are gram-negative gammaproteobacteria found in the marine environment. three strains of pigmented p. piscicida were isolated from seawater and partially characterized by inhibition studies, electron microscopy, and proteolytic enzyme production. growth inhibition and death occurred around colonies of p. piscicida on lawns of the naturally-occurring marine pathogens vibrio vulnificus, v. parahaemolyticus, v. cholerae, photobacterium damselae and shewanella algae inhibi ...201728363962
toxicity of herbal extracts used in ethno-veterinary medicine and green-encapsulated zno nanoparticles against aedes aegypti and microbial pathogens.dengue and chikungunya are arboviral diseases mainly vectored by the mosquito aedes aegypti. presently, there is no treatment for these viral diseases and their prevention is still based on vector control measures. nanopesticides fabricated using herbal extracts as reducing and capping agents currently represent an excellent platform for pest control. in this scenario, the present study assessed the acute toxicity of seven plants employed in ethno-veterinary medicine of southern india, as well a ...201728389893
an outbreak of shigellosis in a children welfare institute caused by a multiple-antibiotic-resistant strain of shigella flexneri 2a.from september 1 to october 27, 2015, an outbreak of bacillary dysentery occurred in the shenzhen children welfare institute (scwi). the shigellosis was uncommon in shenzhen and no related outbreak was reported during the last 5 years. an epidemiological investigation was conducted and the children and nursing workers in scwi were surveyed for gastrointestinal symptoms; 28 of children reported having a diarrheal illness. rectal swabs or fecal specimens from 14 case patients and 24 nursing worker ...201728189512
mice with streptozotocin-induced hyperglycemia are susceptible to invasive enteric bacterial infection.diabetes mellitus and diarrhea are becoming increasingly burdensome worldwide, particularly in developing countries such as india. diabetic patients are susceptible to infection with pathogenic bacteria, particularly those causing invasive enteric infections. in this study, we observed changes in the pathophysiological features of mice with streptozotocin-induced hyperglycemia. in our experiments, both hyperglycemic and control mice were infected with pathogenic enteric bacteria-non-typhoidal sa ...201727169940
dietary yeast sterigmatomyces halophilus enhances mucosal immunity of gilthead seabream (sparus aurata l.).a yeast was isolated from hypersaline sediments, grown and phylogenetically characterized as sterigmatomyces halophilus strainn16. the dietary administration of this yeast was studied for its effect on skin mucosal immune and antioxidant status of gilthead seabream (sparus aurata l.). fish were fed a commercial diet (control, non-supplemented diet), or the same commercial diet supplemented with 0.55% or 1.1% of yeast for 15 and 30 days. one month after the end of the trial, fish from all treatme ...201728315392
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