Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| cervical human papilloma virus infection among the general female population in vietnam: a situation analysis. | human papilloma virus (hpv) is the necessary cause of cervical cancer. this survey used a sample of 1,500 married women aged 15-69 to examine the prevalence of hpv infection and hpv specific types in vietnam as well as risk factors of hpv infection. results indicated that the prevalence of hpv infection in hanoi and hcm was 6.13 and 8.27. the proportion of multiple hpv infection was also higher in hcm than in hanoi (35.5% vs. 17.4%). risk factors having significant associations with general hpv ... | 2011 | 21545230 |
| reported adverse events in girls aged 13-16 years after vaccination with the human papillomavirus (hpv)-16/18 vaccine in the netherlands. | in 2009, human papillomavirus (hpv) vaccination was offered to girls born in 1993-1996 in a catch-up campaign, followed in 2010 by the implementation of the vaccination in the national immunization programme (nip) for girls born in 1997. to monitor the tolerability of the 2009 catch-up campaign, we investigated the occurrence of adverse events within 7 days after vaccination with the bivalent hpv vaccine. a total of 6000 girls were asked to participate, including 1500 from each birth cohort from ... | 2011 | 21549785 |
| working to close the gap: identifying predictors of hpv vaccine uptake among young african american women. | abstract:factors associated with greater likelihood of human papillomavirus (hpv) vaccination among women who experience excess cervical cancer incidence and mortality requires further study. the purpose of this study was to assess factors associated with hpv vaccine uptake among young african american women. three hundred sixty-three african american women aged 18-26 were recruited from historically black colleges/universities to complete a questionnaire to assess health beliefs associated with ... | 2011 | 21551933 |
| considerations on the clinical application of the human papillomavirus vaccine in spain. | the circumstances that in the opinion of the authors influence the lower than expected uptake of the vaccine against human papillomavirus in spain are analyzed. among others, aspects related to doubts about efficacy and safety, the attitude of the spanish health authorities or the role of media and the antivaccine groups, as well as the vaccination "culture" of the gynecologist, are discussed. the authors conclude that only with the coordinated effort of all involved bodies in the vaccination pr ... | 2011 | 21552002 |
| the relationship of knowledge, health value and health self-efficacy with men's intentions to receive the human papillomavirus (hpv) vaccine. | the aim of the present study was to determine whether it was possible to predict human papillomavirus (hpv) vaccination intentions an australian male sample. one hundred and twenty one males aged 18 to 26 (m = 22.3, sd = 2.06), completed an online survey assessing hpv-related knowledge, health beliefs and health self-efficacy. hpv knowledge and health self-efficacy were significant independent predictors of vaccine acceptance. a moderating effect was found between hpv knowledge and health self-e ... | 2011 | 21558104 |
| prevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based study. | persistent high-risk type human papillomavirus (hpv) infection is recognized as a necessary cause of cervical cancer. this study aimed to compare the hpv prevalence and risk factors between women residing in hong kong (hk) and guangzhou (gz) region of china. | 2011 | 21559276 |
| clinical evaluation of polymerase chain reaction reverse hybridization assay for detection and identification of human papillomavirus type 16 variants. | background: isolates of hpv16 comprise six variants: european (eu), asian (as), asian-american (aa), north american (na), african-1 (af1), and african-2 (af2) with different carcinogenic potentials. highly reliable automatable techniques for hpv variant genotyping would be helpful to confirm the role of variants in cervical cancer in large epidemiological studies. objective: to validate the performance of a novel assay for identification of hpv16 variants. study design: the test is a multiplex p ... | 2011 | 21561803 |
| human papillomavirus infection in nasal polyps in a chinese population. | in order to determine the prevalence and genotype distribution of human papillomavirus (hpv) infection in patients with nasal polyps, a total of 204 patients with nasal polyps and 36 healthy controls were recruited in this study. genomic deoxyribonucleic acid (dna) was extracted from paraffin-embedded tissue sections. hpv dna genotyping was achieved by a flow-through hybridization and gene chip method. hpv infection was positively identified in 82 of 204 (40.2%) patients, while hpv dna was not f ... | 2011 | 21562117 |
| human papillomavirus vaccine introduction in low and middle income countries: guidance on the use of cost-effectiveness models. | abstract: background: the world health organization recommends that the cost-effectiveness of introducing human papillomavirus (hpv) vaccination is considered before such a strategy is implemented. however, developing countries often lack the technical capacity to perform and interpret results of economic appraisals of vaccines. to provide information about the feasibility of using such models in a developing country setting, we evaluated models of hpv vaccination in terms of their capacity, req ... | 2011 | 21569406 |
| genital human papillomavirus infection in patients with autoimmune inflammatory diseases. | treatment advances achieved over the last few years have radically changed the management of patients with autoimmune inflammatory diseases requiring conventional or biological immunosuppressive therapy. these diseases and the drugs used to treat them increase the rate of infections, including genital infections due to the human papillomavirus (hpv). genital hpv infections have been extensively studied in organ transplant recipients, hiv-infected patients, and patients with congenital immune def ... | 2011 | 21570889 |
| a protein profile study to discriminate cin lesions from normal cervical epithelium. | background: cervical intraepithelial neoplasia (cin), a frequently encountered disease caused by human papilloma virus (hpv) is often diagnosed in formaldehyde-fixed paraffin embedded (ffpe) punch biopsies. since it is known that this procedure strongly affects the water-soluble proteins contained in the cervical tissue we decided to investigate whether a water-soluble protein-saving biopsy processing method can be used to support the diagnosis of normal and cin. methods: cervical punch biopsies ... | 2011 | 21573931 |
| cancerous inhibitor of protein phosphatase 2a is overexpressed in cervical cancer and upregulated by human papillomavirus 16 e7 oncoprotein. | objectives: cancerous inhibitor of protein phosphatase 2a (cip2a) is a recently identified oncoprotein stabilizing c-myc and promoting cell proliferation and transformation. here we investigated the role of cip2a in cervical cancer in vivo and in vitro. methods: cip2a expression was assessed in normal cervical, cervical intraepithelial neoplasia (cin) i to iii and cervical cancer tissues by immunohistochemistry and rt-pcr. cell growth was explored by cell proliferation assay, colony formation as ... | 2011 | 21575984 |
| the impact of cytology screening and hpv vaccination on the burden of cervical cancer. | aim: to evaluate the impact of different strategies of human papillomavirus (hpv) vaccination on the burden of cervical cancer in singapore. methods: the incidence of cervical cancer was calculated using a markov model with inputs based on singapore data for the prevalence of hpv infection, socioeconomic characteristics and screening prevalence. the evaluation was performed for 10 scenarios: no screening, current opportunistic cytology screening, ideal optimal screening, universal adolescent h ... | 2011 | 21585695 |
| knowledge of pap smear, hpv and the hpv vaccine and the acceptability of the hpv vaccine by thai women. | aims: the primary prevention for cervical cancer, a human papilloma virus (hpv) vaccine, has been available in thailand for almost 3 years. the present study evaluates knowledge about the papanicolaou (pap) smear, hpv and the hpv vaccine and focuses on identifying predictors for the acceptability of the hpv vaccine. methods: a sample of 764 women attending the gynecology clinic at ramathibodi hospital, bangkok, was asked to answer a questionnaire on their personal background, their knowledge o ... | 2011 | 21585696 |
| should males be vaccinated against hpv? | 2011 | 21587022 | |
| cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : a frequency study. | cytopathic effects related to the human papillomavirus (hpv) infection are more frequently found in cervical intraepithelial neoplasia (cin) 1; however, there are indications that at least half the histological diagnoses of cin2 and cin3 include koilocytosis areas. the objective of this study was to evaluate the frequency of the cytological criteria suggestive of hpv infection in the cervical smears of women with a histological diagnosis of cin. one hundred and sixty-two women with abnormal cerv ... | 2011 | 21591275 |
| differential survival trends for patients with tonsillar, base of tongue and tongue cancer in sweden. | tonsillar, base of tongue and tongue cancer have similar anatomical and histopathological appearances but present differences in prognosis. human papillomavirus (hpv) is a known risk factor for tonsillar and base of tongue cancer, and a survival benefit has been shown for these tumors; however, hpv prevalence in tongue cancer is low. tonsillar, base of tongue and tongue cancer patients registered in the swedish cancer registry between 1960 and 2004 were followed from the date of cancer diagnosis ... | 2011 | 21592846 |
| ccnd1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in chinese population. | cyclin d1, with a common g/a polymorphism in rs9344, is an essential regulator of the g1 phase in cell cycles and plays an important role in several tumor types, and the homology of cyclin d1 with human papillomavirus (hpv)-16 e7 brought our attention to ccnd1 gene in cervical cancer. a total of 738 native chinese subjects consist of 327 cases and 411 controls were enrolled in this study. ccnd1 genotyping was analyzed by polymerase chain reaction-restriction fragment length polymorphism (pcr-rfl ... | 2011 | 21594903 |
| green and black tea in relation to gynecologic cancers. | scope: observational studies have evaluated the relationship between green tea intake and cancers of the ovary and endometrium, but we are not aware of the published studies on green tea intake and risk of human papillomavirus (hpv)-related cancers of the cervix, vagina, or vulva. methods and results: a critical review of the published literature on tea intake and risk of ovarian and endometrial cancers was conducted. in meta-analyses, we report inverse associations for green tea intake and risk ... | 2011 | 21595018 |
| molecular epidemiology of hpv infection using a clinical array methodology in 2952 women in greece. | clin microbiol infect abstract: the molecular epidemiology of human papillomavirus (hpv) infection in a sample of greek women (n = 2952, mean age 42.2 ± 13.3 years) was examined. hpv prevalence was 50.7% (95% confidence interval, 48.8-52.6). the most frequent hpv types were hpv 53, 51 and 66 (10.2%, 9.4% and 9.3%, respectively). hpv positivity was associated with age, age of sexual debut, number of sexual partners and duration of sexual relationship, while marriage or multiparity protected again ... | 2011 | 21595788 |
| [papillomavirus and head and neck cancer.] | tobacco and alcohol consumption are the main risk factors for head and neck cancers. papillomavirus (hpv) infection was recently associated with the development of malignant tumors of the oropharynx, according to molecular and biological arguments. we describe the oncogenic mechanisms of hpv infections, the epidemiological and clinical aspects of associated head and neck cancers, their prognosis, and issues of specific therapeutic strategies. | 2011 | 21596407 |
| a case of multiple squamous cell papillomas of the trachea. | we report a case of 68-year-old woman suffering from breathlessness on exertion with stridor. a chest computed tomography showed a tumor arising from the posterior wall of the trachea. the diagnosis was squamous cell papilloma of the surgically removed tumor, which had caused the asphyxiation. after removal of the tumor, the patient received radical therapy: semiconductor laser transpiration. polymerase chain reaction (pcr) detected human papilloma virus (hpv) type 6, thought to be the cause of ... | 2011 | 21597426 |
| [significance for the detection of human papillomavirus dna in cervical atypical glandular cells.] | objective: to evaluate the potential link between high-risk human papilloma virus (hpv)dna testing and histological diagnosis in women referred for atypical glandular cells (agc) at pap smear. methods: all cervical cytological examinations with the diagnosis of agc between january 2007 and dec 2009 were identified by means of a computerized database in 97 patients. the histopathological results of cervix were analyzed by colposcopic biopsy, dilatation and curettage (d&c), cervical loop electrosu ... | 2011 | 21600120 |
| knowledge of hpv in west virginia high school health students and the effects of an educational tool. | study objective: to assess the knowledge of human papillomavirus (hpv) in west virginia high school students, create an educational dvd that could be used as a supplement to health class, and evaluate whether our intervention increases student knowledge of hpv. design: prospective, randomized experimental design with analysis of questionnaire data. setting: west virginia high school health class. participants: a total of 626 students participated. interventions: hpv educational dvd designed by h ... | 2011 | 21600809 |
| follow-up outcomes for a large cohort of us women with negative imaged liquid-based cytology findings and positive high risk human papillomavirus test results. | objective: this study aimed to follow a large group of us women with negative computer-imaged liquid-based cytology (lbc) and positive high risk (hr) hpv dna results. methods: negative lbc and positive hrhpv cases were identified between july 1, 2005 and december 31, 2009. cytologic and histopathologic follow-up results, repeat hpv results, and prior history were analyzed. results: 1099 patients with negative lbc and positive hrhpv results were identified. eight hundred sixty-nine had repeat pap ... | 2011 | 21601911 |
| magnetic microparticle-based multiplexed dna detection with biobarcoded quantum dot probes. | we have developed a new analytical method to detect multiple dna simultaneously based on the biobarcoded cdse/zns quantum dot (qd) and magnetic microparticle (mmp). it was demonstrated by using oligonucleotide sequences of 64 bases associated with human papillomavirus 16 and 18 l1 genes (hpv-16 and hpv-18) as model systems. this analytical system involves three types of probes, a mmp probe and two streptavidin-modified qd probes. the mmps are functionalized with hpv-16 and hpv-18 captures dna to ... | 2011 | 21602038 |
| a long-term prospective study of type-specific human papillomavirus infection and risk of cervical neoplasia among 20,000 women in the portland kaiser cohort study. | background. human papillomavirus (hpv) dna testing is more sensitive than cytology for detection of cervical intraepithelial neoplasia grade 3 and cancer (>cin3). adding hpv testing to cytology is recommended for women >30 but long-term prospective studies of hpv testing are rare. methods. beginning in 1989-1990, ~20,000 women in a pre-paid health maintenance organization (median age = 34) were followed passively by recommended annual cytology. we tested archived cervicovaginal lavage specimens ... | 2011 | 21602310 |
| human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests: systematic review. | to determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard ≥1 relative light units/cut-off level (rlu/co). | 2011 | 21606136 |
| prevalence of human papillomavirus, epstein-barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in hong kong patients. | background: the purpose of this study of human papillomavirus (hpv), epstein-barr virus (ebv), p21, and p53 in sinonasal inverted papilloma (ip) was to help elucidate its pathogenesis. methods: seventy-three ips, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to hpv polymerase chain reaction (pcr) study. seventy-three ips, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to ebv in situ hybridization (ish), p21, and p53 immunohistochemical (ihc) studies. results: h ... | 2011 | 21608063 |
| [detection of human papilloma virus (hpv) in liquid-based cervical samples. correlation with protein p16ink4a expression]. | the liquid-based cervical cytology improves the quality of the sample and the residual sample could be used efficiently to carry out complementary tests, such as the detection of hpv dna and the immunocytochemical biomarkers study. the purpose of this study was to correlate the presence of hpv and immunoexpression of p16ink4a in liquid-based cervical samples to examine the utility of these new tools in the detection of cervical cancer. the included patients (n = 67) presented an abnormal cytolog ... | 2011 | 21614811 |
| a systemic review of human papillomavirus studies: global publication comparison and research trend analyses from 1993 to 2008. | the term "human papillomavirus" has been used as the keyword during searching titles, abstracts, and keywords based on the online version of science citation index (sci), web of science from 1993 to 2008. twelve document types were found among the 14,943 papers published in 1,072 journals that were listed in 99 sci subject categories. all the articles referring to human papillomavirus were assessed by using the following aspects: characteristics of publication output, distribution of output in j ... | 2011 | 21614898 |
| human papillomavirus (hpv) vaccination: perception and practice among french general practitioners in the year since licensing. | acceptance of the human papillomavirus (hpv) vaccine by targeted populations will depend to a large extent on its acceptability among physicians. we examined the perceptions, attitudes and practices of general practitioners (gps) in relation to hpv vaccination. from november 2007 to april 2008, a cross-sectional survey was carried out among a representative 5% sample of gps in the large rhône-alpes region of france. both quantitative (self-administered questionnaire) and qualitative (interview) ... | 2011 | 21616114 |
| human papillomavirus genotypes among infected thai women with different cytological findings by analysis of e1 genes. | cervical cytological data may not be sufficient for cervical cancer screening and prevention. in this project, we determined hpv genotype among infected thai women with different cytological findings by characterization of e1 genes. five hundred and thirty-five specimens were tested by pcr amplification of the e1 genes. hpv genotypes were determined by sequencing, comparison with the genbank database and were analyzed in relation to different cytological findings. hpv-dna by pcr were typed and r ... | 2011 | 21617826 |
| distribution of human papillomavirus genotypes in paraguayan women according to the severity of the cervical lesion. | the incidence of cervical cancer in paraguay is among the highest in the world. this study aimed to determine the distribution of human papillomavirus (hpv) genotypes in paraguayan women, according to the severity of the cervical lesion. this cross-sectional study included 207 women without a squamous intraepithelial lesion, 164 with low-grade squamous intraepithelial lesions, 74 with high-grade squamous intraepithelial lesions, and 41 with cervical cancer. type-specific hpv was determined by th ... | 2011 | 21618554 |
| improved genetic association tests for an ordinal outcome representing the disease progression process. | we are interested in detecting genetic variants that influence transition between discrete stages of a disease progression process, such as the natural history of progression to cervical cancer with the following four stages: (1) normal-human papillomavirus (hpv) exposed, (2) persistent infection with oncogenic hpv, (3) cervical intraepithelial neoplasia grades 2 or 3 (cin2/3), and (4) cervical cancer. standard statistical tests derived from the proportional odds model or polytomous regression m ... | 2011 | 21618605 |
| hpv vaccine information-seeking behaviors among us physicians: government, media, or colleagues? | the multiple information sources available may pose a challenge to physicians in providing accurate human papillomavirus (hpv) vaccine information to patients. the purpose of this study was to describe physicians' hpv vaccine information-seeking behaviors and assess if these behaviors differ by physician specialty and sociodemographic characteristics. in 2009, 1008 family physicians (fps), pediatricians (peds), and obstetricians/gynecologists (obgyns) completed a survey to assess their hpv vacci ... | 2011 | 21619906 |
| clinicopathologic correlations between human papillomavirus 16 infection and beclin 1 expression in human cervical cancer. | our earlier study showed that the autophagy gene beclin 1 could affect cell proliferation in a cervical cancer hela cell line. in this study, we examined beclin 1 protein expression in 81 specimens of cervical squamous carcinoma by immunohistochemistry. meanwhile, we detected e6 and e7 genes of human papillomavirus 16 in these tissues by polymerase chain reaction. beclin 1 expression significantly decreased in samples of malignant cervical cancer tissues than in those of normal or cervical intra ... | 2011 | 21623196 |
| human papillomavirus vaccine: widening the scope for cancer prevention. | human papillomavirus (hpv) is the necessary cause of cervical cancer. the hpv oncoproteins e6 and e7 have crucial roles in various steps of carcinogenesis, inducing degradation of p53 and destabilization of prb. several clinical trials show that recombinant hpv vaccines are safe and effective in preventing persistent infection of hpv and associated anogenital lesions. although most clinical studies to date have investigated the effectiveness of hpv vaccines in young female subjects, elderly fema ... | 2011 | 21465574 |
| targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with ß-cyclodextrin coupled to amino acids. | quantum dots (qds) have the potential to serve as photostable beacons to track sirna delivery, which is fast becoming an attractive approach to probe gene function in cells. in this paper, we synthesized qd nanoparticles coated with ß-cyclodextrin (ß-cd) coupled to amino acids with different surface charges (positive, negative, and neutral) through direct ligand-exchange reactions and used them to deliver sirna. we found that these qds are diffluent in biological buffer with high colloidal stabi ... | 2011 | 21465588 |
| large loop excision of transformation zone procedures used in the management of cytological abnormalities of the cervix. | national health and medical research council (nhmrc) guidelines published in 2005 changed the management of cervical squamous intraepithelial lesions. asymptomatic low-grade abnormalities may be treated conservatively as many regress spontaneously. cervical changes reflect infection with the human papilloma virus (hpv). risk factors for acquiring hpv are the same as those for other sexually transmitted infections (stis). | 2011 | 21466510 |
| prediction of residual/recurrent disease by hpv genotype after loop excision procedure for high-grade cervical intraepithelial neoplasia with negative margins. | this study aims to evaluate whether the preconisation of high-risk human papillomavirus (hr-hpv) genotype and multiple hpv infection is predictive for residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia (cin) treated by loop electrosurgical excision procedure (leep) with negative margins. | 2011 | 21466511 |
| il-10 expression is regulated by hpv e2 protein in cervical cancer cells. | it has been found that certain cytokines (il-4, il-10 and tgf-β1) are highly expressed locally in biopsies from patients with premalignant lesions and cervical cancer, and may induce a local immune-suppression state. in particular, il-10 is highly expressed in tumor cells and its expression is directly proportional to the development of hpv-positive cervical cancer, suggesting an important role of hpv proteins in the expression of il-10. in fact, we demonstrated that e6 and e7 hpv proteins regul ... | 2011 | 21468579 |
| assessment of clinical and analytical performance characteristics of an hpv genotyping test. | human papillomavirus (hpv), the known cause of cervical cancer, is found in essentially all cervical cancer specimens. infection with high-risk hpv genotypes carries the greatest risk of viral persistence and the potential to develop precancerous lesions or cervical cancer. identifying women infected with hpv 16 and/or 18, the two genotypes most commonly found in cervical cancer, helps further stratify women for either immediate referral to colposcopy or repeat cytological and hpv dna testing in ... | 2011 | 21472869 |
| human papilloma virus associated head and neck cancer: a pcr based study. | head and neck cancers (hnc), 90% of which are squamous cell carcinomas (scc), rank sixth among all malignancies worldwide and comprise 40-50% of the total number of malignancies in india. in addition to alcohol and tobacco usage, which is the major source of oral carcinogens, viruses such as human papilloma virus (hpv) may also contribute to development of the malignancy. the aim of this study was to identify the prevalence of hpv in head and neck cancers using material from metastatic site. a t ... | 2011 | 21472871 |
| update on available vaccines in india: report of the appa vu 2010: i. | the asia pacific pediatric association vaccinology update 2010 was held in mumbai on november 13-14, 2010 to discuss the latest information on burden of infectious diseases, recent developments in vaccines and their impact on immunization practices against infectious diseases occurring in indian children. during the conference the importance of including conjugate haemophilus influenzae type b vaccine and anti-rabies vaccines in routine immunization was stressed. also, the need for giving a seco ... | 2011 | 21373831 |
| prevalence of anal intraepithelial neoplasia defined by anal cytology screening and high-resolution anoscopy in a primary care population of hiv-infected men and women. | prevalence of high-grade anal intraepithelial neoplasia, the human papillomavirus-associated putative anal cancer precursor, is high in hiv-infected men who have sex with men, but less is known about its prevalence in other hiv-infected subgroups. similarly, the prevalence of abnormal cytology, used as a screen, is not well-defined in these subgroups. | 2011 | 21383563 |
| lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | lymphoepithelioma-like carcinoma (lelc) in the urinary tract is a rare malignancy, named for its resemblance to nasopharyngeal undifferentiated carcinoma or lymphoepithelioma. investigation of immunohistochemical and molecular characteristics of bladder lelc is limited. the pathogenesis and biological behavior of these tumors are controversial. | 2011 | 21383609 |
| cancer vaccine boosted by infrastructure for hiv care in africa. | 2011 | 21383729 | |
| looking ahead: a case for human papillomavirus testing of self-sampled vaginal specimens as a cervical cancer screening strategy. | even in the era of highly effective human papillomavirus (hpv) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. effective programs must meet three targets: (i) at least 70% of the targeted population should ... | 2011 | 21384341 |
| mitochondrial c150t polymorphism increases the risk of cervical cancer and hpv infection. | during a survey of control region (d-loop) sequence variances in 142 cervical cancer (cc) patients and 136 controls, all chinese women, including both hpv-positive (human papillomavirus) and hpv-negative subjects, we determined that the c150t polymorphism increased the cc risk in a case-control study (or=3.0, 95% ci=1.8-5.0, p<0.05). hpv-positive individuals were more likely to carry the c150t polymorphism than hpv-negative controls (or=5.8, 95% ci=2.6-13.2, p=2.3+ù10(-5)). hpv-positive cc patie ... | 2011 | 21385627 |
| the burden of cervical cancer in china: synthesis of the evidence. | the burden of cervical cancer in china has not been characterized in detail. we reviewed cervical cancer data from national mortality surveys and registries, and conducted a meta-analysis to estimate the prevalence of high-grade lesions (hsil) and high-risk human papillomavirus (hr-hpv) infections in rural shanxi province. we found that a national survey in the 1970s estimated age-standardized cervical cancer mortality rates as ôê+15 and ôê+83/100,000 women nationally and in xiangyuan, shanxi; b ... | 2011 | 21387308 |
| combined promoter methylation analysis of cadm1 and mal: an objective triage tool for high-risk human papillomavirus dna-positive women. | screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (cin3(+)) by high-risk human papillomavirus (hrhpv) testing has as side-effect the detection of hrhpv-positive women without clinically relevant lesions. here, we developed an objective assay assessing the methylation status of the promoter regions of cadm1 and mal to triage hrhpv-positive women for cin3(+). | 2011 | 21389098 |
| factors associated with intention to vaccinate a daughter against hpv: a statewide survey in alabama. | human papillomavirus (hpv) is the most common sexually transmitted infection in the united states. adolescent and young adults aged 15-24 were estimated to account for three quarters of new infections in 2000. two hpv vaccines are currently available. the vaccine is recommended for girls aged 11-12 years. previous research has indicated that african-american and asian-american parents are less likely than caucasians to vaccinate their daughters. this investigation examines the relationship betwe ... | 2011 | 21397534 |
| human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis. | whether the oncogenic human papillomavirus (hpv) infection, especially infection with the most common subtypes 16 or 18, is related to prostate carcinogenesis remains conflicting. a meta-analysis with updated data was performed to obtain a more precise estimate of the association between them. | 2011 | 21400096 |
| altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. | abstract conclusions: altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (scc) independent of human papilloma virus (hpv) infection may lead to tumor progression. objectives: integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. hpv is significantly associated with tonsillar scc. we sought to determine the expression of claudin-1, claudin-7, and tricellulin in hpv-infected and hpv-free tonsillar scc ... | 2011 | 21480761 |
| cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. | please cite this paper as: sharma m, ortendahl j, van der ham e, sy s, kim j. cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. bjog 2011; 10.1111/j.1471-0528.2011.02974.x. objective to assess the health and economic outcomes of various screening and vaccination strategies for cervical cancer prevention. design cost-effectiveness analysis from a societal perspective. setting thailand. population females aged 9 years and older. methods using a ... | 2011 | 21481160 |
| hpv vaccine acceptability in ghana, west africa. | cervical cancer is a leading cause of cancer-related mortality among women in ghana. as of this writing no data are available concerning knowledge, attitudes and acceptability of human papillomavirus (hpv) vaccination by women in ghana. | 2011 | 21481327 |
| design and characterization of an enhanced repressor of human papillomavirus e2 protein. | papillomaviruses are causative agents of cervical and anogenital cancers. the viral e2 protein mediates viral dna replication and transactivation of viral oncogenes and thus represents a specific target for therapeutic intervention. short forms of e2, e2r, contain only the c-terminal dimerization domain, and repress the normal function of e2 due to formation of an inactive heterodimer. using structure-guided design, we replaced conserved residues at the dimer interface to design a heterodimer wi ... | 2011 | 21482558 |
| advancing human papillomavirus research with a rhesus monkey model. | 2011 | 21483022 | |
| immunogenicity and reactogenicity of alternative schedules of hpv vaccine in vietnam: a cluster randomized noninferiority trial. | human papillomavirus (hpv) vaccine programs may decrease the morbidity and mortality due to cervical cancer seen among women in low-resource countries. however, the 3-dose schedule over a 6-month period is a potential barrier to vaccine introduction in such settings. | 2011 | 21486975 |
| smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. | background:to prove a causal link between an epigenetic change and an environmental or behavioural risk factor for a given disease, it is first necessary to show that the onset of exposure precedes the first detection of that epigenetic change in subjects who are still free of disease.methods:towards this end, a cohort of women aged 15-19 years, recruited soon after they first had sexual intercourse, were used to provide sequential observations on the relationship between cigarette smoking and t ... | 2011 | 21487403 |
| [current events in vaccination.] | the annual meeting of the infectious disease society of america (idsa); which brought together nearly 5000 participants from over 80 countries in vancouver, canada, october 21 to 24, 2010; provided a review of the influenza (h1n1) 2009 pandemic, evaluated vaccination programmes and presented new vaccines under development. with 12 500 deaths in the united states in 2009-2010, the influenza (h1n1) 2009 pandemic was actually less deadly than the seasonal flu. but it essentially hit the young, and ... | 2011 | 21489733 |
| transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. | β-human papillomavirus (β-hpv) dna is present in some cutaneous squamous cell carcinomas (cusccs), but no mechanism of carcinogenesis has been determined. we used ultra-high-throughput sequencing of the cancer transcriptome to assess whether papillomavirus transcripts are present in these cancers. in all, 67 cuscc samples were assayed for β-hpv dna by pcr, and viral loads were measured with type-specific quantitative pcr. a total of 31 sccs were selected for whole transcriptome sequencing. trans ... | 2011 | 21490616 |
| medical interventions for high grade vulval intraepithelial neoplasia. | vulval intraepithelial neoplasia (vin) is a pre-malignant condition of the vulval skin; its incidence is increasing in women under 50 years. vin is graded histologically as low grade or high grade. high grade vin is associated with infection with human papilloma virus (hpv) infection and may progress to invasive disease. there is no consensus on the optimal management of high grade vin. the high morbidity and high relapse rate associated with surgical interventions call for a formal appraisal of ... | 2011 | 21491403 |
| impact of an hpv6/11/16/18 l1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with hpv16/18 infection. | the impact of a human papillomavirus (hpv) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (cin2-3/ais) in women with ongoing hpv16 or 18 infections prevaccination is reported. seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 randomized, placebo-controlled, efficacy trials (protocols 013 and 015). vaccine or placebo was given at day 1, month 2 and 6. women were tested for hpv6/11/16/18 dna and antibodies at da ... | 2011 | 21491420 |
| the combined influence of oral contraceptives and human papillomavirus virus on cutaneous squamous cell carcinoma. | the vast majority of cutaneous squamous cell carcinoma (cscc) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (uvr) exposure. organ transplant recipients also are an important population at great risk for cscc. an association has been reported between oral contraceptive (oc) use, human papillomavirus virus (hpv) and cervical cancer, and there could be a similar association for cscc. the cutaneous hpv β-e6 protein, a close cousin of the transformative e6 ... | 2011 | 21499554 |
| single-chain fv fragment antibodies selected from an intrabody library as effective mono- or bivalent reagents for in vitro protein detection. | in spite of their many potential applications, recombinant antibody molecules selected by phage display are rarely available commercially, one reason being the absence of robust bacterial expression systems that yield sufficient quantities of reagents for routine applications. we previously described the construction and validation of an intrabody library that allows the selection of single-chain fv (scfv) fragments solubly expressed in the cytoplasm. here, we show that it is possible to obtain ... | 2011 | 21501618 |
| detection of human papillomavirus using hybrid capture 2 in oral brushings from patients with oropharyngeal squamous cell carcinoma. | detection of high-risk (hr) human papillomavirus (hpv) in oropharyngeal squamous cell carcinoma (scc) has important prognostic implications; patients exhibit improved survival compared with patients with hpv- scc. oral brushing and rinsing samples were obtained from patients with oropharyngeal, oral cavity, or hypopharyngeal scc and tested for hr-hpv using hybrid capture 2 (hc2; qiagen, valencia, ca). hr-hpv in situ hybridization (ish) was performed on biopsy tissue samples from the same patient ... | 2011 | 21502432 |
| a population-based clinical trial comparing endocervical high-risk hpv testing using hybrid capture 2 and cervista from the shenccast ii study. | our objective was to directly compare the accuracy of the high-risk human papillomavirus (hpv) assays, hybrid capture 2 (hc2; qiagen, gaithersburg, md) and cervista (hologic, bedford, ma), in diagnosing cervical intraepithelial neoplasia (cin) 3 or worse (cancer). a population-based, cross-sectional study (the shenzhen cervical cancer screening trial ii) was conducted in guangdong province in china. three high-risk hpv assays, self and direct cervical sampling and cytology, were studied. abnorma ... | 2011 | 21502436 |
| phase 1 randomized trial of the vaginal safety and acceptability of spl7013 gel (vivagel) in sexually active young women (mtn-004). | objectives:: the study was designed to assess the safety, adherence, acceptability, and effect on vaginal microflora of 3% spl7013 gel (vivagel), a novel dendrimer topical microbicide that inhibits hiv, herpes simplex virus-2, and human papillomavirus in vitro and in animal models. design:: phase 1, randomized, double-blind, placebo-controlled study on sexually active women. methods:: sixty-one sexually active women aged 18-24 years were recruited from three sites in the united states. participa ... | 2011 | 21505316 |
| hpv e6 proteins target ubc9, the sumo conjugating enzyme. | the human papillomavirus oncogenic protein, e6, interacts with a number of cellular proteins, and for some targets, e6 directs their degradation through the ubiquitin-proteasome pathway. post-translational modification with ubiquitin-like modifiers, such as sumo, also influences protein activities, protein-protein interactions, and protein stability. we report that the high risk hpve6 proteins reduce the intracellular quantity of the sole sumo conjugation enzyme, ubc9, concomitant with decreased ... | 2011 | 21510985 |
| human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in argentina. | reports on the prevalence and genotypes of hpv among trans (male to female transvestites, transsexuals or transgender) sex workers (tsw) are scarce in the literature. | 2011 | 21511521 |
| multiplexed detection of nucleic acids in a combinatorial screening chip. | multiplexed diagnostic testing has the potential to dramatically improve the quality of healthcare. simultaneous measurement of health indicators and/or disease markers reduces turnaround time and analysis cost and speeds up the decision making process for diagnosis and treatment. at present, however, most diagnostic tests only provide information on a single indicator or marker. development of efficient diagnostic tests capable of parallel screening of infectious disease markers could significa ... | 2011 | 21512691 |
| "i thought cancer was one of those random things. i didn't know cancer could be caught…": adolescent girls' understandings and experiences of the hpv programme in the uk. | the uk human papillomavirus (hpv) vaccination programme aims to provide girls aged 12-13 with protection against two of the most carcinogenic strains (types 16 and 18) of this sexually transmitted virus which together account for 70% of cases of cervical cancer. despite evidence suggesting a general lack of knowledge about hpv and its link with cervical cancer, vaccine uptake rates were generally high in the uk for the first year of the hpv vaccination programme. in countries that implemented th ... | 2011 | 21514348 |
| anogenital warts in danish men who have sex with men. | to determine the prevalence of anogenital warts (agws) and concurrent sexually transmitted infections (stis) in men who have sex with men (msm), and their knowledge of human papillomavirus (hpv). attitudes towards the hpv vaccine among msm are explored. a web-based cross-sectional survey on agws, sociodemographic factors and sexual behaviour conducted in august 2009 in denmark. overall 25.2% of the 1184 respondents reported a prior or current episode of agws. the prevalence of agw was significan ... | 2011 | 21515754 |
| incidence of cervical intraepithelial neoplasia grade 2 or worse in colposcopy-negative/human papillomavirus-positive women with low-grade cytological abnormalities. | please cite this paper as: kelly r, walker p, kitchener h, moss s. incidence of cervical intraepithelial neoplasia grade 2 or worse in colposcopy-negative/human papillomavirus-positive women with low-grade cytological abnormalities. bjog 2011; doi: 10.1111/j.1471-0528.2011.02970.x objective to determine the risk of incident high-grade cervical intraepithelial neoplasia (cin) in human papillomavirus (hpv) -positive women with low-grade cytological abnormalities who had a satisfactory normal colp ... | 2011 | 21624034 |
| prevalence and distribution of high risk human papillomavirus (hpv) types 16 and 18 in carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in the general population in karnataka, india. | background: in view of conducting hpv vaccination in india it is most important to understand the prevalence of hpv genotypes in this population, not only in squamous cell carcinoma of cervix and oral cavity but also in the general population. in this study we explored the prevalence and distribution of high-risk hpv types 16 and 18 in carcinoma of cervix, saliva of patients with oral squamous cell carcinoma and in general population in karnataka. methods: cervical cancer specimens after punch b ... | 2011 | 21627358 |
| detection of high-risk human papillomavirus types 16 and 18 but not 33 and 52 in external genital warts from iranian females. | background: external genital warts (egw) are relatively common sexually transmitted diseases. in the majority of cases, low-risk human papilomaviruses (hpv), such as hpv-6 and hpv-11, are responsible but, high-risk types may also be detected and this has a bearing on vaccines for cervical cancer prevention. in this study the incidence of the high-risk hpv types 16, 18, 33 and 52 in egws of females from the southwest of iran was assessed. methods: seventy-nine women with egws participated in this ... | 2011 | 21627381 |
| a competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the guanacaste natural history study. | background. a competitive luminex immunoassay (clia) has been developed to measure neutralizing antibodies against human papillomavirus (hpv) types 6, 11, 16 and 18. methods. in a cohort of 974 women from the guanacaste natural history study, we studied the relationship of baseline clia and virus-like particle (vlp) enzyme-linked immunosorbent assay (elisa) (hpv16 and hpv18 only) seropositivity to measures of hpv exposure, hpv dna positivity, number of sexual partners, cytology findings, and age ... | 2011 | 21628663 |
| improved sensitivity of vaginal self-collection and high-risk human papillomavirus testing. | background: self-collected vaginal specimens tested for high-risk human papillomavirus (hr-hpv) have been shown to be less sensitive for detection of cervical intraepithelial neoplasia or cancer (≥cin 3) than physician-collected endocervical specimens. to increase the sensitivity of self-collected specimens, we studied a self-sampling device designed to obtain a larger specimen from the upper vagina (poi/nih self-sampler) and a more sensitive pcr based hr-hpv assay. materials and methods: 10,000 ... | 2011 | 21630255 |
| hpv vaccine against hpv infection and disease in males. | 2011 | 21631334 | |
| an evaluation of a new dna test for carcinogenic human papillomavirus. | using archived specimens, we evaluated a new automated real-time pcr assay (bd diagnostics), which detects all carcinogenic hpv and provides hpv genotyping for seven of them, including hpv16 and hpv18, the two most carcinogenic hpv genotypes. we found comparable results with hybrid capture 2 (hc2) for detection of carcinogenic hpv (n = 473) and with linear array and line blot assay (n = 371) for detection of individual hpv genotypes. | 2011 | 21632892 |
| oncogenic potential of human papillomavirus (hpv) and its relation with cervical cancer. | abstract: human papillomavirus (hpv) is the most common cause of cervical cancer. cervical cancer being the second most common cancer after lung cancer, affecting women of different age groups; has a prevalence of about 20% in young sexually active women. among different types of hpv, hpv16 the major strain causing this cancer and is sexually transmitted had been unnoticed for decades. keeping in mind the multiple risk factors related with cervical cancer such as early age sexual activities, tee ... | 2011 | 21635792 |
| reduced mir-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting plk1 protein. | aim: although aberrant mirnas expression has been documented, altered mir-100 expression in cervical cancer and precursor tissues and its carcinogenic effect and mechanism remain unexplored. the aim of our study was to investigate the role of mir-100 alteration in cervical carcinogenesis. methods: the expression of mir-100 was examined by quantitative real-time reverse transcriptase pcr (qrt-pcr) in 125 cervical tissues including normal cervical epithelium, cervical intraepithelial neoplasia (ci ... | 2011 | 21636267 |
| the epidemic of hpv-associated oropharyngeal cancer is here: is it time to change our treatment paradigms? | although relatively uncommon, oropharyngeal cancers are increasing in incidence despite declining prevalence of smoking and in direct opposition to a decreasing incidence of all other head and neck cancers. an epidemic of human papillomavirus (hpv)-associated oropharyngeal cancers seems to account for these incidence trends. important demographic, behavioral, and prognostic characteristics define this unique population. changes in prevention, diagnosis, evaluation, staging, and treatment are nee ... | 2011 | 21636538 |
| hpv protection in older groups may be in the eye of the beholder. | 2011 | 21647126 | |
| quadrivalent papillomavirus vaccine in women over age 26. cervical screening must remain a priority. | 2011 | 21648175 | |
| antitumor therapeutic and antimetastatic activity of electroporation-delivered human papillomavirus 16 e7 dna vaccines: a possible mechanism for enhanced tumor control. | dna vaccines are known to be lacking in immunogenicity in humans. presently, electroporation (ep) is thought to overcome this limitation. here, we investigate whether human papillomavirus 16 e7 dna vaccines delivered by ep might elicit potent antitumor activity in animal cervical cancer models, with a focus on the underlying mechanism(s). intramuscular (im)-ep delivery of e7 dna vaccines induced more potent antitumor therapeutic and antimetastatic activity compared with im delivery. moreover, th ... | 2011 | 21649506 |
| providing vaccines against human papillomavirus to adolescent girls in the americas: battling cervical cancer, improving overall health. | vaccines against the human papillomavirus (hpv)--the primary cause of cervical cancer--target adolescent girls, many of whom have limited contact with health services. countries in the americas are beginning to use hpv vaccines to increase the impact of cervical cancer programs and as an entry point to broader health services for girls. this strategy opens new opportunities to improve lifelong health habits; encourage regular cervical cancer screening and treatment, when necessary; and offer ass ... | 2011 | 21653962 |
| serum antibodies to the hpv16 proteome as biomarkers for head and neck cancer. | human papillomavirus (hpv) type 16 is associated with oropharyngeal carcinomas (opc). antibodies (abs) to hpv16 e6 and e7 oncoproteins have been detected in patient sera; however, abs to other early hpv-derived proteins have not been well explored. | 2011 | 21654689 |
| pcr study of a series of ascus cases hpv-positive by hcii. | most guidelines currently recommend the testing of human papillomavirus (hpv) in ascus cases. the most used method for this purpose is hybrid capture ii (hcii), but pcr techniques with gp5+/6+ primers can be also applied. furthermore, the hcii high-risk probe test for detection of hpv shows cross-reactivity with low-risk hpv. although this cross-reactivity has been studied in screening populations, it has received little attention in ascus cases. to compare the performance of the hcii high-risk ... | 2011 | 21656701 |
| prognostic implication of high risk human papillomavirus e6 and e7 mrna in patients with intraepithelial lesions of the cervix in relationship to age. | since the introduction of the cytological screening programs, a significant reduction in the incidence of cervical cancer has been achieved. almost all of these cancers are related to high-risk (hr) human papillomavirus (hpv) cervical infections. however, the natural history of hpv infection seems to be different in younger patients, resulting in a higher rate of regression. there is, therefore, the need to identify hpv-related biomarkers in order to enhance the effectiveness of screening of hig ... | 2011 | 21658320 |
| adult immunizations: update on recommendations. | the advisory committee for immunization practices recommends universal influenza vaccination for 2010-2011. older adults should be offered protection against herpes zoster, and younger adults should receive immunization against human papilloma virus and pertussis. hepatitis b vaccination should be encouraged in non-immune adults. recommendations also address vaccinations for tetanus/diphtheria, hepatitis a, pneumococcus, measles/mumps/rubella, and meningococcus. | 2011 | 21658665 |
| [investigation on hpv dna detection and genotyping practices used in french laboratories in 2009]. | the french national reference laboratory for human papillomavirus (hpv) performed in 2009 a national study in order to review the methods used to detect and identify hr hpv genotypes in microbiology laboratories. results from this study show a great diversity in volumes of samples treated in laboratories. among clinical indications, the most frequent is a result of asc-us at a pap smear. this indication in the only one covered by the national public insurance system and is mostly performed in la ... | 2011 | 21659046 |
| meeting of the who human papillomavirus vaccine advisory committee, april 2010. | 2011 | 21661272 | |
| new technologies and advances in colposcopic assessment. | to have a good grasp of clinical colposcopy, it is necessary to understand the histopathologic structure of the normal and dysplastic cervical epithelium. previous meta-analyses had indicated high overall sensitivity of colposcopy in detecting dysplastic lesions, but recent studies have suggested that the technique has much lower sensitivity in detecting high-grade intraepithelial neoplasia. the best practice in colposcopy relies on accurately taking a biopsy from the correct (i.e. most morpholo ... | 2011 | 21664876 |
| human papillomavirus dna and mrna positivity of the anal canal in women with lower genital tract hpv lesions: predictors and clinical implications. | women with hpv related pathology of the lower genital tract are at higher risk for ain and anal cancer than the general population. a strategy to identify anal disease in these women has not been formulated. the aim of this study is to examine the feasibility of hpv related biomarker testing on anal smears, to identify the risk factors for anal hpv positivity and to provide information of the clinical implications of anal hpv infection in this population. | 2011 | 21665253 |
| the role of human papillomavirus on sperm function. | to review the role of human papillomavirus (hpv) on sperm parameters, fertility and implication of the use of infected sperm cells in assisted reproduction. | 2011 | 21666465 |
| transforming activity of a novel mutant of hpv16 e6e7 fusion gene. | an optimized recombinant hpv16 e6e7 fusion gene (hpv16 ofe6e7) was constructed according to codon usage for mammalian cell expression, and a mutant of hpv16 ofe6e7 fusion gene (hpv16 omfe6e7) was generated by site-directed mutagenesis at l57g, c113r for the e6 protein and c24g, e26g for the e7 protein for hpv16 ofe6e7 [patent pending (cn 101100672)]. the hpv16 omfe6e7 gene constructed in this work not only lost the transformation capability to nih 3t3 cells and tumorigenicity in scid mice, but a ... | 2011 | 21667341 |
| higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis. | no studies have investigated dietary differences between head and neck squamous cell carcinoma (hnscc) patients with human papillomavirus (hpv)-positive tumors and patients with hpv-negative tumors. this study was designed to investigate the relationship between diet and hpv status in hnscc patients. cases of hnscc were recruited from 2 clinical centers participating in the university of michigan head and neck specialized program of research excellence (spore). hpv tissue genotyping was performe ... | 2011 | 21667401 |