Publications

detection of antibodies to aspergillus fumigatus in ager gel with different antigens and immunodiffusion patterns.		1976	819444
[pathomorphology of pulmonary aspergillosis in tuberculosis patients based on according to resection material].	to investigate various manifestations of broncho-pulmonary aspergillosis and to ascertain its association with a previous disease there were carried out histotopographic, histological and mycological studies of specimens of the lung tissue resected in 37 patients in connection with aspergillomas of the lungs and broncho-pulmonary aspergillosis. the investigations showed that aspergillosis was one of the forms of dysbacteriosis in the human organism and could develop against the background of pos ...	1976	779726
sources and incidence of airborne aspergillus fumigatus (fres).	specific surveys of the air for aspergillus fumigatus were carried out in rural and urban situations over a 2-year period. overall, low concentrations of spores were recorded with a higher incidence during the "winter" months. counts in the open air and in a hospital ward showed similar fluctuations, the indoor counts being consistently lower. plant debris in the form of compost heaps and stacks of hay and straw baled with a high moisture content in which self-heating occurs, produces large numb ...	1976	780000
treatment of fungal sinusitis with autogenous vaccine. (a case report).		1976	782005
unusual mycotic findings in cytodiagnosis.		1976	785916
ige antibodies in bronchopulmonary aspergillosis.	total serum ige and serum ige antibodies to a. fumigatus were quantitated in 143 patients with different forms of bronchopulmonary aspergillosis. total serum ige levels were elevated in all patients with allergic bronchopulmonary aspergillosis but also in some other forms of bronchopulmonary aspergillosis, thus limiting the diagnostic value of total serum ige determination in this type of pulmonary mycotic infection. specific ige antibodies to a. fumigatus could be demonstrated in all patients w ...	1976	786083
[aspergillus serum precipitins in patients of a lung clinic].	the incidence and distribution of aspergillosis among patients of a lung clinic in west berlin were recorded. the immunodiffusion test (idt) was used on sera of 228 patients seen during one day to test for precipitins against a. fumigatus, a. flavus, and a. niger. precipitating antibodies specific against a. fumigatus were found in five patients, in two of them a. fumigatus was isolated simultaneously from sputum. in order to obtain a clear view of the clinical occurrence of asperigillosis and i ...	1976	821738
intraocular effects of pimaricin.	pigmented rabbits weighing 3 to 6 lbs were given bilateral intraocular injections of 250 to 1,000 mug pimaricin. following their injection, blood, aqueous and vitreous levels were determined at various time intervals during the first 24 hours and at 24 hour intervals thereafter for one week. in subsequent studies, pigmented rabbits were given bilateral intraocular injections of 5,000 spores of a. fumigatus and 30 hours later received intraocular injections of 250 to 1,000 mug pimaricin. these st ...	1976	786132
depletion of complement in vivo and in vitro by extracts of aspergillus fumigatus.	a new, nontoxic material extracted from aspergillus fumigatus, is described with complement-depletion capacity both in vivo and in vitro. extracts of the mycelium of a. fumigatus were found to haemolyse sheep red blood cells, to be lethal for mice and to convert c3 into its faster electrophoretic form when incubated with normal human serum. conversion did not take place when purified c3 was used, suggesting that serum factors were required in the reaction. adsorption of the extracts with activat ...	1976	786901
an appraisal of impregon as a deterrent of domestic fungus growth.	impregon brand of tetrachlorsalicylanilide (tcsa) has been profferred widely as a household fungistatic agent, although its value remains unproved. to assess its effects, this agent was used as a laundry and paint additive and as a treatment for burlap rug backing; after recommended applications of impregon, coded replicate materials were inoculated with mixed suspensions of fungus particles. no difference was evident in fungus growth points on fabric swatches washed in tap water with and withou ...	1976	787049
aspergillus prosthetic valve endocarditis.	the clinical, laboratory, and histopathological features of seven cases of aspergillus fumigatus prosthetic valve endocarditis are presented. the exact nature of the lesion, a combination of infective fungal endocarditis and thrombosis on the prosthetic valve, is discussed and the difficulties in clinical diagnosis are emphasized. helpful indications were sudden unexplained heart failure with the appearance of new murmurs, and emboli to large or medium-sized systemic arteries. fever and anaemia ...	1976	788218
rast using crude and purified anti-ige.	the sensitivity of the rast using anti-ige in 125i-labelled igg fractions of sheep antiserum was compared to that using anti-ige purified by immunosorbent techniques in tests with three allergens (grass pollens, aspergillus fumigatus and the detergent enzyme "alcalase") on sera from 248 workers in a detergent factory. both anti-ige reagents measure the same antibody but the rast procedure using the crude anti-ige reagent is less sensitive than that using the immunosorbent-purified anti-ige in it ...	1976	788951
combination amphotericin b-rifampin therapy for pulmonary aspergillosis in a leukemic patient.	pulmonary aspergillosis developed in a 62-year-old man with acute myelogenous leukemia. therapy with amphotericin b and 5-fluorocytosine was begun. synergy between amphotericin b and rifampin was demonstrated in vitro, and therapy with firampin replaced 5-fluorocytosine. progressive clearing of the pulmonary lesion ensued, suggesting in vivo efficacy as well. further studies of patients utilizing this regimen are warranted.	1976	789031
mycotic aneurysm of the thoracic aorta caused by aspergillus fumigatus.	a 54-year-old diabetic patient had unexplained fever and embolic occlusion of the splenic, right renal, right hypogastric, right superficial femoral, and left popliteal arteries. aspergillus fumigatus was recovered from a femoral clot. an aortogram revealed a mycotic aneurysm of the thoracic aorta to be the source of the infected emboli. surgical excision of the aneurysm and therapy with amphotericin b were unsuccessful.	1976	776547
bronchopulmonary aspergillosis. an epidemiological study in a hospital population.	in order to determine the incidence of bronchopulmonary aspergillosis in patients with other types of pulmonary pathology, 586 in-patients, out-patients and controls were examined during the period 1968-1970 in baguley hospital, manchester, england. it was found that from the 344 in-patients and out-patients with other pulmonary pathology, 6 had a definite diagnosis of allergic aspergillosis. 1 had pulmonary aspergilloma while 53 other patients demonstrated some evidence of bronchopulmonary aspe ...	1976	778964
roentgenographic recognition of bronchoceles.	bronchoceles often have characteristic plain film, tomographic, and bronchographic appearances, and they may trap air. roentgenographic recognition of bronchoceles can allow them to be distinguished from neoplasms and sometimes help avoid unnecessary surgery.	1976	798296
[properties of the contagious ecthyma virus used for vaccine production].	experiments were carried out to establish the effect of some antibiotics and merthiolate on the vaccinal phylaxia strain of ecthyma contagiosa. besides, followed up was the effect of these antibiotics on concomitant microflora that had multipled in the virus suspension. trials were also made to titrate the vaccinal strain on lambs through scarification. titration was carried out by the method of schmidt. virus dilutions of 10-1 were applied following scarification on the the thighs and fore limb ...	1976	799865
mycotic keratitis in nigeria. a study of 21 cases.	a clinical and mycological study of 21 cases of mycotic keratitis, a clinical entity not yet reported from nigeria or west africa, showed that fusarium solani was the predominant aetiological agent. it was isolated from 12 cases. four of the remaining nine cases were caused by aspergillus fumigatus, one by a. flavus, two by penicillium citrinum, and one each by p. expansum and penicillium sp. all the 12 isolates of f. solani grew well at 37 degrees c and survived at 40 degrees c. two cases, one ...	1976	791355
isolation of actinomycetes and fungi from mouldy hay using a sedimentation chamber.		1976	791914
extrinsic allergic alveolitis after aspergillus fumigatus inhalation. evidence of a type iv immunologic pathogenesis.	three weeks after a massive inhalation of mold present on infected oats, a farmer's wife had extrinsic allergic alveolitis. aspergillus fumigatus was cultured from the moldy oats and from deep bronchial washings obtained at fiberoptic bronchoscopy. spores and hyphae characteristic of aspergillus species were demonstrated within granulomas in the pulmonary tissue obtained by transbrochial biopsy. serum precipitins, delayed (48 hour) cutaneous hypersensitivity and in vitro lymphocyte transformatio ...	1976	795300
[stages of development of aspergillus-mycetom and their roentgenographic signs (author's transl)].	a series of 13 cases of aspergillus-infection in the respiratory tract are reviewed. a case of rapid development of an intrapleural aspergillus-mycetom is presented. a complete series of chest roentgenograms and operation-photos allowed to demonstrate like with a quick-motion apparatus 3 stages of development of an intrapleural aspergillus-myceton: i. infection through aspergilli of a residual intrapleural cavity by the bronchial way. pleural thickening as reaction to the irritation. ii. develop ...	1976	799407
morphogenesis and pathogenesis of chronic lung diseases. viii. cellularization of lung interlobular areas as a preliminary phase of peribronchovascular fibrosis.	an experimental investigation of the lung interlobular areas was performed by elicitation of rabbits with antigens (aspergillar and human-serum proteins) administered in aerosols or intramuscularly in freund's adjuvant. the cell accumulations in the interlobular areas developed irrespective of the antigen, duration of exposure and route of administration. the cells accumulated (reticulo-lymphoid, plasma cells, eosinocytes) were counted and the areal surface measured. the total cell count and the ...	1976	772786
the relative susceptibility of new zealand black and cba mice to infection with opportunistic fungal pathogens.	the susceptibility of ageing new zealand black (nzb) mice to infection with a number of opportunistic fungi and yeasts wsd compared with that of similarly aged mice of the cba strain. the nzb mice showed a greater susceptibility to lethal infection with aspergillus fumigatus, candida albicans and cryptococcus neoformans than did those of the cba strain. both mouse strains showed similar susceptibility to lethal infection by allescheria boydii, absidia corymbifera, mucor pusillus and rhizopus ory ...	1976	772839
radioallergosorbent test (rast) studies with insolubilized polysaccharides.	polysaccharide preparations from aspergillus fumigatus and candida albicans when used with some human sera were found to fix complement and precipitate with specific antibodies present in the sera. precipitins consisted predominantly of igg with traces of igm and iga. following insolubilization of the fungal polysaccharide preparations with the n-carboxyanhydride of l-leucine, reactivity with serum precipitins was retained and reaction with ige antibodies was demonstrated using the radioallergos ...	1976	795563
[the possibility of an etiopathogenetic role of the fungi isolated from the respiratory tract (author's transl)].	the large number of fungous strains isolated from specimens coming from the respiratory tract is a possible source of diagnostic failures. for an accurate diagnosis it is necessary to screen between fungi in a saprophitic and in a parasitic position. this is very difficult both for fungi, which are largely spread in the environment, like aspergillus sp., and for fungi, which are commonly found on the mucous membranes, like candida or torulopsis sp. the actual pathogenetic activity of a fungous s ...	1976	797323
[an antigenic extract analyzed by bidimensional immunoelectrophoresis (author's transl)].	an antigenic extract from broth culture of aspergillus fumigatus has been analyzed by bidimensional immunoelectrophoresis of clark and freeman against rabbit antiserum. the analysis has show the extract to be constituted by seven different antigens.	1976	797324
[fluorescence immunologic studies of aspergillus fumigatus antibodies].		1976	782944
acquired immunity to aspergillus fumigatus.	in mice preinfected with aspergillus fumigatus for greater than or equal to days, administration of cortisone failed to stimulate mycelial growth. the liver and heart of mice preinfected for 14 days resisted infection after a cortisone + conidia challenge.	1976	776836
[effect of different ratios and concentrations of carbon and nitrogen in the medium on the growth and toxin formation of aspergillus fumigatus fres].		1976	781478
salmonella and aspergillus infections in common loons overwintering in florida.	during a 5-year period (1970-1975), 190 common loons (gavia immer) from overwintering populations on the east and west coasts of florida were examined for evidence of infectious diseases. salmonella spp (representing 8 serotypes) were isolated from 27 (14%) of the loons, and lesions typical of those produced by aspergillus fumigatus were found in 34 (18%) of the loons. seven loons were infected with salmonella spp and had lesions typical of aspergillus infection. the largest number of loons (124 ...	1976	789314
hatchery problems--a field report.	a long term investigational, advisory and monitoring exercise with a major hatchery emphasised the multi-disciplinary approach adopted by the agricultural development and advisory service (adas) to raise the performance of the many aspects of chick production. these included an investigation of egg handling techniques from nest box to hatcher; the adoption by the hatchery of plastic setter trays; an improvement to incubator environment; an improvement in the overall hatchery hygiene programme an ...	1976	769299
direct fungal infection of the eye and its prevention.		1976	791354
intravitreal effects of pimaricin in experimental fungal endophthalmitis.	evaluation of 25, 50, and 100 mug of pimaricin given intravitreally to albino rabbits with aspergillus endophthalmitis revealed that 25 mug of pimaricin, while nontoxic to the retina, was ineffective in inhibiting the fungal process. a dose of 50 mug was significantly more effective in inhibiting fungal disease but also caused significant retinal damage with loss of retinal function and iridoplegia. dosages above this level resulted in vitreous retraction and degeneration, iridoplegia, and retin ...	1976	766638
mechanism of uptake of strontium isotopes in aspergillus lesions.	observations on experimental aspergillosis of chorioallantoic membranes confirmed that strontium-85 uptake in aspergillus lesions was directly due to infection by the fungus. such uptake was not found in normal or in toxoplasma gondii-infected control membranes. further, the avidity of radionuclide uptake was proportional to the mycelial mass, as previously observed clinically. investigations on 85sr containing malt extract broth aspergillus fumigatus cultures revealed that fungal hyphas did not ...	1976	769615
hemoptysis with cavitary lung lesion.		1976	792492
[dependence of the growth and toxin formation of aspergillus fumigatus fres.on the cultivation temperature].		1976	792639
[comparative enzymatic study of two strains of aspergillus fumigatus and of a. fischeri of sapropytic origin or isolated from human or animal lesions: practical diagnostic applications].	14 enzymatic activities (3 dehydrogenases and 11 hydrolases) were systematically investigated in the extracts of 2 strains of aspergillus fischeri and 14 strains of a. fumigatus (8 isolated from human or animal lesions named 'pathogenic' strains and 6 strains of saprophytic origin). the enzymic composition of a. fumigatus appeared to be very different from one strain to another but no relationships could be established between enzymic differences and origin of the strains. in addition, the immun ...	1976	792691
[immuno-enzymatic technic (e.l.i.s.a.) applied to the serological diagnosis of human candidiasis and aspergillosis. preliminary results].		1976	792812
[pleural aspergillosis in clinical records in the years 1965-1974].		1976	792829
[removal of pulmonary aspergilloma by aspiration drainage].		1976	794564
[the effect of clotrimazole (canesten) on the ultrastructure of molds (aspergillus fumigatus) in the infected animal].		1976	794709
conditional virulence of a p-aminobenzoic acid-requiring mutant of aspergillus fumigatus.	the induced auxotrophy for p-aminobenzoic acid (paba) resulted in a complete loss of virulence of aspergillus fumigatus for normal as well as cortisone-treated mice. the paba-requiring mutant of a. fumigatus survived in vivo for 4 to 7 days without causing any infection. however, it showed conditional virulence in animals receiving paba in very small quantities. repeated inoculations of the viable spores of the avirulent mutant strain gave favorable results in building immunity against intraveno ...	1976	770331
pleural aspergillosis: a case report.	the first case of pleural aspergillosis on either american continent since 1958 is reported. the recent literature is reviewed. the pleura is infected by aspergillus through bronchopleural or pleurocutaneous communication. surgical removal of aspergillus infected pleura is the cornerstone of therapy.	1976	773232
effect of cetylpyridinium chloride on pathogenic fungi and nocardia asteroides in sputum.	the effect of cetylpyridinium chloride (cpc) on pathogenic fungi and nocardia asteroides was studied. sputa seeded with each of 11 organisms (aspergillus flavus; aspergillus fumigatus, blastomyces dermatitidis, candida albicans, coccidioides immitis, cryptococcus neoformans, geotrichum candidum, histoplasma capsulatum; nocardia asteroides, paracoccidioides brasiliensis, and sporothrix schenckii) were treated with cpc and kept for 2, 5 and 9 days. the cpc reagent used (0.5% cpc and 0.5% sodium ch ...	1976	773957
immunologic monitoring and aspergillosis in renal transplant patients.	three cases of pulmonary aspergillosis in a "high risk" population of renal transplant recipients are presented. the source of infection was traced to the forced air exhaust system of the transplantation unit. early definitive diagnosis of the infection was very important for effective management. immunologic monitoring was demonstrated to be instrumental in indicating the early presence of infection, and as a guideline to reduced immunosuppression during therapy. bronchoscopy with brushings and ...	1976	766657
[experimental abortions in mice and guinea pigs caused by aspergillus fumigatus spores].	experiments were carried out with a total of 82 laboratory animals including 56 mice and 26 guinea pigs. the possibility was tested to provoke abortions in them with the use of aspergillus fumigatus spores introduced through the trachea, orally or vaginally. the mould was isolated on chapek agar from an aborted bovine fetus. it was found that all three routes of infection lead to abortions setting in after three to five treatments on the 1st to 3rd day following the last introduction of spores. ...	1976	769306
mycotoxicoses.		1976	15366
serological investigations in 15 cases of bird fanciers disease.	serological studies in 15 patients with bird fanciers disease are reported. quantitative analysis of serum proteins showed elevation of igg in almost every case. high ige was observed in three patients with isolated asthmatic reactions. in four patients alpha1-antitrypsin was transiently diminished. two of these had heterozygous deficiency of this protein (genotype ms and mz). precipitins against avian sera and avian droppings were found in all patients, but also in some exposed and nonexposed c ...	1976	55391
serum concentration of specific ige antibody against aspergillus fumigatus and identification of the fungal allergen.		1976	58749
lymphocyte sensitization to aspergillus fumigatus antigens in pulmonary diseases in man.	in vitro studies of t-lymphocyte responses using five different batches of aspergillus fumigatus antigens, were undertaken in twelve patients with a. fumigatus related lung disease and in three normal controls. using a leucocyte migration method, five of the twelve patients showed significant inhibition of leucocyte migration with a migration index of 0-80 or less to a. fumigatus, but in only three was this demonstrated with more than one batch of antigen (one patient with aspergilloma and two w ...	1976	59639
positive controls for fungal detection in tissue sections.	lyophilized histoplasma capsulatum, coccidioides immitis, blastomyces dermatitidis and aspergillus fumigatus are rehydrated, evenly dispersed, and made into smears using a bacteriological loop and alcohol-cleaned slides. smears are air dried for 15 minutes, fixed in concentrated formaldehyde fumes for 30 minutes, postfixed for one hour in ten per cent buffered formaldehyde, and stored at room temperature. these preparations are used as positive controls for the grocott stain as recommended for c ...	1976	60881
cytophilic antibodies in bronchopulmonary aspergilloma and cryptogenic pulmonary eosinophilia.	the immunoglobulin class and subclass of cytophilic antibodies have been studied using peripheral leucocytes from twenty-two patients with allergic bronchopulmonary aspergillosis, aspergilloma and cryptogenic pulmonary eosinophilia. in patients with allergic bronchopulmonary aspergillosis, significantly increased histamine liberation occurred following challenge of their leucocytes with antisera to ige, igg2, igg3 and igg4 as well as with aspergillus fumigatus antigen. the results were considera ...	1976	63346
antigenic variability of aspergillus fumigatus strains.	the effect of culture media, temperature of incubation, and continuous shaking of cultures, on the reactivity and yield of antigens of aspergillus fumigatus were evaluated. it was found that aoac medium was superior to czapek medium and shake cultures yielded better results than stationary cultures. however, antigens from stationary cultures in aoac medium incubated at 30 degrees c for 3 weeks were equally as good as antigens obtained from 2-week-old shake cultures. antigens from 11 selected str ...	1977	82195
studies on the toxin of aspergillus fumigatus. vii. purification and some properities of hemolytic toxin (asp-hemolysin) from culture filtrates and mycelia.	a hemolytic toxin has been obtained from mycelia and culture filtrates of aspergillus fumigatus by the procedures that included precipitation with ammonium sulfate, chromatography of deae-sephadex, affinity chromatography on concanavalin a-sepharose and gell filtration on sephadex g-50, g-100 and g-150. the purified homolytic toxin was homogeneous on immunological and disk electrophoretic analysis, and the toxin from culture filtrates was identical with that from mycelia by the immunodiffusion t ...	1977	16196
phosphate uptake and involvement of binding protein in tween-80 supplemented culture of aspergillus fumigatus.	tween-80 supplementation in submerged culture of aspergillus fumigatus resulted in an increase of phosphate uptake. the uptake system was characterized as saturable, energy-dependent and operating against the concentration gradient. control and tween 80 cultures showed similar km values for phosphate uptake (50 micrometer). cold osmotic shock treatment of the cultures was found to cause considerable reduction in the ability to take up phosphorus with concomitant release of the binding protein in ...	1977	18385
enzymatic release of iron from sideramines in fungi. nadh:sideramine oxidoreductase in neurospora crassa.	young mycelia of the fungus neurospora crassa contain a soluble nadh-linked sideramine reductase, which may be responsible for liberating iron in vivo from accumulated sideramines during iron-deficient cultivation. the enzymes can be assayed using a soluble supernatant fraction, edta, and an atmosphere of pure nitrogen. the enzyme is stable without loss of activity up to 45 degrees c and has an optimum of activity at ph 7.0. besides coprogen (km = 100 micrometer, v=2.8 nmol/min per mg protein), ...	1977	144535
epidemiologic aspects of allergic aspergillosis.	the incidence of allergic bronchopulmonary aspergillosis (aba) seems much less in the united states than in great britain. the suggestion that there are differences in the atmospheric burden of a. fumigatus prompted the authors to evaluate skin reactivity to a. fumigatus in their clinic population. immediate skin reactivity was found significantly less than to alternaria, a common midwest mold. because of the association of a. fumigatus with decaying vegetation, compost piles in the st. louis ar ...	1977	320921
interspecific protoplast fusion and complementation in aspergilli.		1977	321242
the effect of freezing and the influence of isolation medium on the recovery of pathogenic fungi from sputum.	the primary objective of this study was to determine whether freezing sputa in dry ice had any effect on the recovery of pathogenic fungi. sputa seeded with each of five fungi (histoplasma capsulatum, blastomyces dermatitidis, cryptococus neoformans, coccidioides immitis, and aspergillus fumigatus) were frozen and stored for 24, 48, and 72 hours on dry ice. h. capsulatum was killed, and only a few colonies of b. dermatitidis and c. neoformans were isolated from these sputa. however, a. fumigatus ...	1977	335251
occurrence of spores of thermophilic fungi in the air at bombay.		1977	320470
effect of phosphate on ergot alkaloid synthesis in aspergillus fumigatus.	high concentration of inorganic phosphate in the culture medium of aspergillus fumigatus inhibited ergot alkaloid synthesis. addition of l-tryptophan but not mevalonate or 5-methyltryptophan to the above culture restored the alkaloid synthesis to the level found in normal cultures. the decrease in alkaloid synthesis in the fungus accompanies an increase in cell mass, cellular protein and sterol content. aspartate aminotransferase and alanine aminotransferase activities were significantly increas ...	1977	336488
role of biotin in ergot alkaloid formation by aspergillus fumigatus.		1977	336519
examination of the effect of age and acquired immunity on the susceptibility of mice to infection with aspergillus fumigatus.	adult cba mice showed considerably greater resistance to experimental infection with aspergillus fumigatus than young animals of the same strain (p less than 0.01). furthermore, in contrast with the young mice, the susceptibility of the adults was only moderately increased by treatment with cortico-steroids. on the other hand, immunosuppressive treatments producing severe depression of lymphocyte function greatly increased susceptibility to lethal infection and promoted fungal growth in a wide r ...	1977	321970
counterimmunoelectrophoresis and opportunistic fungal infections.	sera from 35 apparently normal humans, 37 compromised human patients, 30 hedgehogs and 30 sheep, were examined for precipitating antibodies to four opportunistic fungi - absidia corymbifera, aspergillus fumigatus, candida albicans and rhizopus arrhizus-using counterimmunoelectrophoresis (cie). precipitins to a. fumigatus were almost exclusively confined to specimens obtained from the compromised human group (51% of those examined) while candida precipitating antibodies were detected in the sera ...	1977	321971
germination of aspergillus fumigatus conidia in the lungs of normal and cortisone-treated mice.	inhaled conidia of aspergillus fumigatus germinated in the lungs of mice at a low rate but both germinated and ungerminated spores were cleared. spores germinated at a high rate in the lungs of cortisone-treated mice.	1977	323999
aspergillosis in imported penguins.	an outbreak of aspergillosis in imported penguins caused by aspergillus fumigatus is described. the birds probably acquired the infection from the country of origin or during their transportation. predisposing circumstances are discussed.	1977	324000
vertebral aspergillosis with preservation of the disc.		1977	338084
diagnosing allergic bronchopulmonay aspergillosis.		1977	338111
aspiration biopsy in plumonary opportunistic infections.		1977	324215
asthmatic pulmonary eosinophilia: a review of 65 cases.	in a series of 65 patients with asthma with pulmonary eosinophilia 54 were adequately investigated for allergic aspergillosis and this was present in 32 (59%). asthma with pulmonary eosinophilia was found to carry a relatively poor prognosis in terms of permanent symptoms, impairment of pulmonary function and residual radiographic abnormality. the prognosis was least favourable when allergic aspergillosis was associated with long-standing asthma. on the other hand there was a group of patients w ...	1977	324510
the influence of 5-fluorocytosine on nucleic acid synthesis in candida albicans, cryptococcus neoformans, and aspergillus fumigatus.	5-fluorocytosine (5-fc) has a rapid inhibitory effect on the synthesis of rna and dna in the yeast and hyphal form of candida albicans. 5-fc has a less marked effect on the rna and dna content of sensitive strains of cryptococcus neoformans and has no effect on the nucleic acid content of aspergillus fumigatus nor of resistant strains of c. albicans and c. neoformans. 5-fc has a slower inhibitory effect on yeast cell number increase and no effect on hyphal length of hyphal phase c. albicans over ...	1977	324722
sporulation and spore liberation in aspergillus fumigatus.		1977	325416
the uptake of aspergillus fumigatus protein by serum igg antibody from patients with pulmonary aspergillosis.	a method is presented for measuring the uptake of aspergillus fumigatus protein by igg antibodies from human serum. the human igg is first isolated with an anti-igg conjugated immunosorbent and then incubated with radio-iodinated a. fumigatus protein. a group of twenty-three control sera gave the same background levels as tests without sera. the highest uptake of a. fumigatus protein was given by the sera of patients with aspergilloma, and lower values were obtained with six out of thirteen sera ...	1977	326434
four years experience with dura mater cardiac valves.	the clinical use of homologous dura mater cardiac valves was begun in january 1971. between january 1971 and may 1975, 751 patients received 849 dura mater valves: 428 mitral, 365 aortic, 52 tricuspid and 4 pulmonary. the hospital mortality observed in this series was 13.6% and late mortality was 2.5%. the main causes of death were low-output syndrome in the immediate post-operative period or cardiac failure in the late post-operative period, due to myocardial impairment. paravalvular leaks and ...	1977	325013
treatment of fungal infections with miconazole.	the present study reports on 15 patients with confirmed or suspected secondary fungal infection, who were treated with intravenous miconazole and a daily dose of 0.4 to 28 g (mean 9.8 g). the mycological findings confirmed infection with aspergillus fumigatus in 6 patients and severe infection with candida albicans in 4. clinically mycological cures were achieved in 4 patients and some improvement was found in 3 others. the excellent patient tolerance of the drug makes it seem a likely treatment ...	1977	122648
bronchocentric granulomatosis: a complication of allergic bronchopulmonary aspergillosis.	hypersensitivity to the fungal antigens of aspergillus fumigatus may result in a spectrum of immune injury collectively known as allergic bronchopulmonary aspergillosis (abpa). this report describes a 14-yr-old boy who presented clinical findings consistent with abpa,including a history of asthma, blood eosinophilia, serum precipitins, and ige antibodies to aspergillus fumigatus. sputum aspergillus, pulmonary infiltrates, and dual types i and iii skin reactions to aspergillus fumigatus were obse ...	1977	319138
maize silage: incidence of moulds during conservation.	the basic principle of silage making--preservation under anaerobiosis--is recognized. with this environment the substrate can harbour a spontaneous and active microflora that can be divided into two sequential phases; a bacterial phase followed by a yeast phase. the imperfections of the techniques used in making silage, however, frequently result in invasion by fungi. the moulds that are responsible for serious changes (loss of nutrients, mycotoxins) are classified into a dozen characteristic di ...	1977	328359
[effect of fungicides on aspergilus fungi].		1977	100848
experimental pulmonary aspergillosis in sensitized rabbits.		1977	142913
[the aspergillus sinusitis (author's transl)].		1977	327467
surgical treatment of pulmonary aspergilloma.	fourteen patients with aspergilloma (fungus ball) were reviewed. hemoptysis was the major symptom (93%). chest roentgenograms disclosed a "fungus ball" in every patient, and the mycelia of aspergillus fumigatus were recovered from all resected specimens. one of three patients treated by pneumonectomy died post-operatively. a lobectomy was performed in ten patients, and segmental resection in one without mortality or significant morbidity. there has been no evidence of recurrence in a follow up o ...	1977	327952
mycotoxins produced by aspergillus fumigatus species isolated from molded silage.		1977	328548
allergic bronchopulmonary aspergillosis in a cane-sugar mill.	allergic bronchopulmonary aspergillosis is reported in two (1.5%) of 131 workers occupationally exposed to aspergillus fumigatus at the u.d. sugar mills, shamli. twelve of the workers revealed type i (9.2%) and three (2.8%) type iii skin hypersensitivity against with fungus. serum preciptins were demonstrated in two out of 44 workers and positive sputum cultures in 26 out of 58 workers. it is suggested that constitutional predisposition of the host may be a more important factor than the extent ...	1977	329408
studies in chronic allergic bronchopulmonary aspergillosis. 3. immunological findings.	precipitin tests by two different methods, double-diffusion (dd) and counterimmunoelectrophoresis (cie), and measurements of total and specific ige against aspergillus fumigatus were made in 50 patients with chronic allergic bronchopulmonary aspergillosis and in three control groups--atopics with a positive immediate prick test to a. fumigatus but no evidence of allergic aspergillosis, atopics with a negative prick test to a. fumigatus, and non-atopics. precipitins were found in 84% and 78% of t ...	1977	329461
therapy of murine aspergillosis with amphotericin b in combination with rifampin of 5-fluorocytosine.	suboptimal doses of amphotericin b in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated aspergillus fumigatus infection in mice. despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradicated infections in the mice when evaluated by mycological culture, even in long-term survivors.	1977	319750
improved methods of producing precipitating aspergillus antigens.	improved methods for producing aspergillus fumigatus antigens capable of giving sensitive and reproducible results by counterimmunoelectrophoresis (ciep) are described. among the factors investigated were the source of casein hydrolysate used for n source, method of incubating the ciep slide following a run, effect of freeze pressing and lyophilization, age of culture and ratio of c to n source in the medium.	1977	320920
[studies on the toxin of aspergillus fumigatus. viii. biological properties of asp-hemolysin (author's transl)].		1977	342741
[apropos of a case of invasive pulmonary aspergillosis with subadjacent aspergilloma].		1977	343198
paranasal aspergilloma caused by an albino variant of aspergillus fumigatus.	an unusual case of aspergilloma in the maxillary sinus caused by an albino variant of aspergillus fumigatus var ellipticus is presented. removal of the fungus ball by a left caldwell-luc procedure resulted in complete recovery for the patient. this case is the 17th culturally proven case of paranasal aspergilloma caused by a fumigatus, the third case reported from the united states, the first case due to aspergillosis caused by an albino strain of a fumigatus.	1977	327569
[incorporation of glycine and serine in sideramines of the ferrichrome type with fungi of the genus aspergillus in vivo and in vitro (author's transl)].	a 1.6-11.8% incorporation of labelled glycine and serine into ferrichrome, ferricrocin and ferrichrysin has been achieved with four strains of aspergillus in vivo. cell-free extracts of aspergillus fumigatus and a. quadricinctus capable of cyclohexa-peptide biosynthesis have been prepared.	1977	327964
natural occurrence of aspergillus fumigatus in cane sugar mills.	the environmental distribution of aspergillus fumigatus in 2 cane-sugar mills and one paper factory in northern india is compared with 2 localities in delhi. the preponderance of the species at the u.d. sugar mills, shamli, was contrary to its low prevalence in the university of delhi campus and at subzimandi, the vegetable and fruit market of delhi. aspergillus fumigatus accounted for 42.5% of the total aerial fungal colony counts recorded in the shamli mills as against 2% in delhi. the predomi ...	1977	341368
[mycological and clinical studies on a new local antimycotic drug].		1977	334661
safety evaluation of aspergillus fumigatus grown on cassava for use as an animal feed.	a safety evaluation of aspergillus fumigatus i21, grown in a cassava carbohydrate and salts medium, was undertaken. male weanling rats were fed the fungus at 20, 30 and 40% of the diet for 90 days. a control group was given soybean oil meal as the sole source of protein. weekly determinations of the body weights and feed consumptions were made. a few days prior to termination of the feeding study, a kidney function test was undertaken on the rats. at the end of the feeding period hematology, blo ...	1977	336162
[experimental studies in animals on the influence of fluocortin butylester on the course of generalized infections (author's transl)].	the influence of butyl 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester, vaspit), a new corticosteroidal compound with a marked dissociation between local antiinflammatory and systemic action, upon resistance against infections was studied in experimental bacterial and fungal infections in mice. the results of the experiments showed, that fluocortin butylester, even after repeated s.c. or oral administration of dosages up to 100 mg/kg did not d ...	1977	341900
treatment with antifungal vaccines.		1977	342190
[pathogenesis of mycotic abortion in cows].		1977	329555
chitin biosynthesis in protoplasts and subcellular fractions of aspergillus fumigatus.	the biosynthesis of chitin has been obtained in broken mycelia and protoplasts of the fungus aspergillus fumigatus. the specific activity of chitin synthase (ec 2.4.1.16) in a membrane preparation from protoplasts derived from the hyphal tips of a. fumigatus was 26.8-fold greater than that of the chitin synthase in broken mycelia, indicating that the active chitin synthase is located primarily in a membrane-bound site at the hyphal tip. polyoxin d was a potent competitive inhibitor of the enzyme ...	1977	329836
[aspergillosis of the brain].	a case of aspergillosis of the brain in a 49-year old woman is described. in view of the fact that there were no inflammatory changes in other organs, the assumption was put forward that the fungus had penetrated into the brain by the otogenic way, or through the accessory nasal sinuses. the results of experimental infection of laboratory animals aimed at obtaining a model of meningoencephalitis are discussed. it was shown that spores of the aspergillus fumigatus fungus in low concentrations int ...	1977	332126
the metabolism of phenylacetic acid by aspergillus fumigatus atcc 28282: identification of 2,6-dihydroxyphenylacetic acid.	aspergillus fumigatus atcc 28282 converted phenylacetic acid into a new dihydroxylated compound (2,6-dihydroxyphenylacetic acid) which was identified as 2,6-dimethoxyphenylacetic acid methyl ester. two other new metabolites have been isolated also and identified as orthohydroxyphenylacetic acid and meta-hydroxyphenylacetic acid.	1977	332293
circulating immune complexes and activation of the complement sequence in acute allergic bronchopulmonary aspergillosis.	a 13-yr-old asthmatic girl with allergic bronchopulmonary aspergillosis (abpa) exhibited eosinophilia, ige hypergammaglobulinemia, serum precipitins to aspergillus, a dual skin reaction to aspergillus fumigatus, and positive, lymphocyte transformation in vitro in response to stimulation with aspergillus fumigatus antigen. the acute phase of the disease was characterized by an increase in blood eosinophilia, a rise in serum ige, circulating immune complexes, and evidence of activation of the comp ...	1977	144747