Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| effects of influenza infection, aspirin, and an arginine-deficient diet on the inner ear in reye's syndrome. | the individual effects of an influenza b viral infection, aspirin, and an arginine-deficient diet on the inner ear were assessed in the ferret model for reye's syndrome using both functional and morphological parameters. auditory brainstem evoked responses recorded from inoculated ferrets revealed threshold elevations and increased latencies during the first 72 hours, but approximated those of control animals by 96 hours. although there was a mild distention of reissner's membrane, no pronounced ... | 1984 | 6508126 |
| changes in the morphology of influenza particles induced at low ph. | at low ph influenza virus causes membrane fusion. this phenomenon is thought to reflect a part of the infection mechanism of the virus. to obtain more information on the effect of low ph on the virus, the change in morphology of influenza virus particles was studied by electron microscopy. further, the degradation of haemagglutinin (ha) after trypsin digestion as a function of ph was studied by gel electrophoresis. the results showed that a threshold value existed below which both a change in mo ... | 1984 | 6508530 |
| [immunity against influenza virus types a and b in the ruhr region]. | haemagglutination-inhibiting antibodies against influenza virus types a and b were determined in the sera of 733 healthy persons among the population of the ruhr region. the receptivity rate for the total population to strains a/philippines 2/82 (h3n2) and a/brazil 1/78 (h1n1) was 60% and 80%, respectively. it was as high as greater than 95% with respect to type b (hongkong). these findings support the call for more widespread anti-influenza vaccination during the winter half-year. | 1984 | 6510247 |
| investigation of a temporal cluster of left sided congenital heart disease. | during october and november 1977, eight newborns with critical congenital heart disease, six of these with left sided lesions, were admitted to a new jersey newborn unit serving two predominantly rural counties with 9700 annual live births. the six left heart lesions (three cases of hypoplastic left heart, two of interrupted aortic arch, and one of aortic coarctation) represented 30% of all neonatal left sided lesions seen at the unit in the three year period 1976-8. the scan statistic for tempo ... | 1984 | 6512489 |
| influenza--a reminder. | 1984 | 6517006 | |
| [viral-microbial associations and the function of humoral factors of natural immunity in acute pneumonia patients]. | a total of 359 patients with acute pneumonia and 152 practically healthy subjects comprising the control group were examined. immunofluorescence was used to investigate nasopharyngeal washings for detecting antigens of influenza and parainfluenza viruses, respiratory-syncytial virus, adenoviruses, whereas serological studies according to the hemagglutination delay test with diagnostic agents for detecting influenza a1, a2, b, types 1, 2 and 3 parainfluenza, and the complement fixation test were ... | 1984 | 6523359 |
| [changes in the population composition of the peripheral blood lymphocytes and the humoral immune response of persons inoculated with live influenza vaccines]. | live influenza vaccines prepared from influenza virus strains h/32/5 (h1n1) and h/1/2/17 (h3n2) induce the formation of humoral immunity only in a part of the vaccinees and cause the transitory quantitative deficiency of t-lymphocytes in their blood, resulting in the poorly pronounced booster effect of the subsequent revaccination. | 1984 | 6524175 |
| biochemical and serological studies of influenza b viruses: comparisons of historical and recent isolates. | the genetic characteristics of 24 representative influenza b viruses isolated in widely different geographical areas of the world between 1940 and 1980 were analysed using either rna:rna hybridisation or oligonucleotide mapping. additional biochemical characterisation included electrophoretic analysis of virus-induced polypeptides and virion rnas. a panel of monoclonal antibodies to virus ha was used to investigate serological relationships between the viruses. the influenza b viruses examined c ... | 1984 | 6532003 |
| complete nucleotide sequence of the influenza c/california/78 virus nucleoprotein gene. | the complete nucleotide sequence of rna segment 5 of the influenza c/california/78 (c/cal/78) virus was determined by using cloned cdna derived from viral rna. the gene contains 1809 nucleotides and can code for a protein of 565 amino acids with a molecular weight of 63 525. the rna 5 protein of the influenza c/cal/78 virus possesses two short regions which share a high degree (60-83%) of sequence homology with the nucleoproteins of influenza a and b viruses. these and other structural features ... | 1984 | 6532006 |
| a specific sub-set of host-cell mrnas prime influenza virus mrna synthesis. | the host-cell derived rna primer sequences at the 5' termini of mrnas of influenza a and b viruses, obtained from sequences of 29 cdna clones, have been compared. this has been done for clones of five different genome segments from four strains of influenza a and b virus. the results indicate that host rna primers containing a 3'-terminal py-g-c-a sequence before the presumed endonuclease cleavage site are preferred for use as primers in influenza virus mrna synthesis. primer-extension analyses ... | 1984 | 6532008 |
| [epidemiologic surveillance of influenza in rome (1981-1982)]. | in the period from september 1981 to april 1982, one strain of influenza virus (a-h3n2) was isolated from 121 throat cultures obtained from patients with acute febrile respiratory disease. a sero-epidemiological survey on 520 serum samples and evaluation of excess mortality from respiratory diseases did not show significant activity of influenza viruses during the period from october 1981 to october 1982. | 1984 | 6534394 |
| influenza surveillance in rio de janeiro between 1980-1981: a virological and serological study. | laboratory surveillance of influenza has shown a low virus activity in rio de janeiro during 1980 and 1981. a few influenza a (h3n2) viruses were isolated in both years during the winter months. serological investigations showed that this subtype has circulated mostly among children under 10 years of age. no h1n1 virus was isolated but an increase in the proportion of adults with antibody to this virus was noted in sera collected in 1981. influenza b virus was isolated from children in the sprin ... | 1984 | 6535914 |
| [influenza b in moldavia (romania) in the spring of 1984]. | 1984 | 6537631 | |
| [outbreak of influenza b in jilin province]. | 1984 | 6543743 | |
| [epidemiological characteristics of influenza due to virus a and b in moldavia in 1957-1983. a synthesis of the research]. | 1984 | 6545970 | |
| influenza in melbourne, 1982. epidemiology and virology. | the major features of the outbreaks of influenza a and b, which occurred in melbourne during the winter of 1982, are described. diagnoses of influenza a or influenza b were established in 310 patients by virus isolation, immunofluorescence, and serological tests. immunofluorescence was found to be a valuable, rapid, but considerably less sensitive, test than virus isolation, and serodiagnosis was the test of choice either when patients did not present or when specimens were not collected until l ... | 1984 | 6377029 |
| [test system for detecting and differentiating the influenza virus by an immunoenzyme method]. | detection and differentiation of small amounts of influenza a and b viruses was done by enzyme-immunoassay based on detection of the complex of internal proteins. it was shown that two kinds of sera to the complex of internal proteins could be used: sera against disrupted viruses grown in a different system (mice or cell culture) and containing almost no cam component for virus detection in the allantoic fluid of chick embryos, and sera to preparations of viruses grown in chick embryos and disru ... | 1984 | 6388159 |
| [functional and antigenic activity of the supercapsid proteins of influenza a and b viruses isolated by a combination of enzyme and electrophoretic methods]. | 1984 | 6393585 | |
| [virus-inhibiting properties of the carbonyl-conjugated pentaene roseofungin]. | the antiinfluenza activity of roseofungin, a polyenic macrolide antibiotic was studied in vitro on surviving fragments of the chick embryo chorionallantoic membranes and in ovo on growing chick embryos. it was shown that the antibiotic activity against influenza a and b viruses was sufficiently high. the activity of roseofungin against influenza a virus did not differ from that of remantadin, the most active inhibitor of influenza virus reproduction. however, the activity of roseofungin against ... | 1984 | 6331293 |
| [detection of antibody to type b influenza virus in pig populations in china]. | 1984 | 6241081 | |
| serological diagnosis of influenza a and b infections by enzyme immunoassay. comparison with the complement fixation test. | paired sera from 784 patients with symptoms of acute respiratory disease were examined for antibodies against influenza a, b and parainfluenza (1 and 3) viruses by complement fixation (cf) and enzyme immunoassay (eia). the internal variation of the eia test results was low and an increase of 0.250 in absorbance values which corresponded to a two-fold increase in end-point titres was considered a diagnostic antibody rise. eia detected significantly more diagnostic rises than the cf test in the ca ... | 1984 | 6094610 |
| [antimicrobial protection of the respiratory tract in advanced silicosis complicated by chronic obstructive bronchopneumopathy]. | 1984 | 6097996 | |
| an experimental study of the inhibition effect of pang qi ju on influenza viruses. | 1984 | 6098885 | |
| detection of influenza virus by means of immune sera to m and rnp inner proteins in solid phase radioimmunoassay. | solid phase radioimmunoassay (spria) was shown suitable for detection of influenza virus in various biological materials using immune sera (is) to membrane protein (mp) and ribonucleoprotein (rnp) isolated from the strain a/ussr/90/77. either serum was able to detect influenza a viruses with different haemagglutinins (h1, h3, h7) and did not react with influenza b viruses. spria detected 0.3 ng viral protein per 1 ml, i.e. its sensitivity was 20 times higher than that of the haemagglutination (h ... | 1984 | 6152127 |
| antiviral activity of norakin (triperiden) and related anticholinergic antiparkinsonism drugs. | in view of the coincidence of antiviral and antiparkinsonism activities of amantadine four antiparkinsonism drugs, norakinr (triperiden), parkopanr (trihexyphenidyl), antiparkinr (diethylbenzhydramine) and akinetonr (biperiden) were tested for antiviral activity in various virus-cell systems. norakin inhibited the replication of influenza a viruses in chick embryo fibroblast, mdck and ehrlich ascites tumour cells. it also inhibited the replication of measles virus in vero cells, 50% inhibitory c ... | 1984 | 6152129 |
| [unconscious state in influenza b infection]. | 1984 | 6700988 | |
| potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza b virus: a possible mechanism for human reye's syndrome? | using weanling mice of two different genetic strains we demonstrated a potentiation of the toxic effects of acetaminophen by prior infection with influenza b virus. the c57bl/6n (b6) strain of mice is genetically predisposed to increased toxicity from acetaminophen when the hepatic cytochrome p-450 mixed function oxidase system is preinduced. when b6 animals are pretreated with influenza b virus and an mixed function oxidase system inducing agent before administering acetaminophen, we observed a ... | 1984 | 6701047 |
| combined interferon-alpha 2, rimantadine hydrochloride, and ribavirin inhibition of influenza virus replication in vitro. | recombinant dna-produced human interferon-alpha 2 inhibited the replication of influenza a and b viruses in primary rhesus monkey kidney cells (rmk). human interferon-alpha 2 interacted additively or synergistically with rimantadine hydrochloride or ribavirin in reducing the yield of clinical isolates of either h3n2 or h1n1 subtype influenza a viruses. the combination of human interferon-alpha 2 and ribavirin also inhibited the replication of an influenza b virus to a greater extent than either ... | 1984 | 6703684 |
| [effect of ribavirin on the reproduction of influenza b virus]. | the influence of ribavirin on influenza b virus reproduction was studied at different experimental levels. ribavirin was found to reduce significantly the production of hemagglutinin and accumulation of infectious influenza b/lee/40 virus in mdck cell culture. synthesis of virus-specific polypeptides of influenza b/hong kong/5/72 virus was markedly reduced in its presence. ribavirin in a dose of 100 mg/kg inhibited the infectious titre of influenza b/lee/40 virus considerably and prevented the d ... | 1984 | 6730434 |
| a one-year study of trivalent influenza vaccines in primed and unprimed volunteers: immunogenicity, clinical reactions and protection. | three hundred volunteers were divided into two age groups, 14-30 years and 31-60 years. each participant was immunized intramuscularly with a subunit, whole virus or absorbed whole virus vaccine, containing a/bangkok/1/79 (h3n2), a/brazil/11/78 (h1n1) and b/singapore/222/79 influenza virus. serum haemagglutination-inhibition (hi) antibody response, protection, and reactogenicity were studied after one and two doses of the vaccines. primary immunization induced much higher percentages of hi antib ... | 1984 | 6736638 |
| isolation and preliminary characterization of a highly cytolytic influenza b virus variant with an aberrant ns gene. | by repeated backcrosses of influenza virus a/aichi/2/68 (h3n2) with b/yamagata/1/73 in mdck cells, a virus clone with ha of b serotype (clone b/610b5b/201, or clone 201) was obtained, which formed sharp plaques in mdck cells and induced a severe cell lysis early after infection. its structural proteins were indistinguishable from those of b/yamagata. electrophoresis of the rna of the clone also showed an identical pattern to that of b/yamagata except rna segment 8 (ns gene), which migrated faste ... | 1984 | 6740944 |
| inner ear changes in the ferret model for reye's syndrome. | the acute effects of influenza b, aspirin, and hyperammonemia on the inner ear were examined using the ferret model for reye's syndrome. histopathologic examination revealed varying degrees of vacuolization in both the sensory and nonsensory endolymphatic tissues of the cochlear and vestibular membranous labyrinth. the secretory epithelial cells of the stria vascularis and the vestibular dark cells appeared to be more severely affected, as demonstrated by the presence of an extensive number of i ... | 1984 | 6742340 |
| abortive infection of l cells by influenza b virus: defect in bud formation. | host-dependent restriction of influenza b virus replication in l cells was analysed in comparison with productive infection in mdck or 1-5c-4 cells. the synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive l cells were similar to those in permissive mdck cells. however, an electron microscopic study of infected l cells showed neither extracellular virions nor budding virus particles on the cell surface, in contr ... | 1984 | 6748967 |
| results of a two-year study of humoral immunity to influenza a and b viruses in children under the age of 14 years in moscow and its suburbs. | a serological survey of antibodies to influenza a(h1n1), a(h2n2), a(h3n2) and b viruses was done with sera collected in moscow in october 1980 and november 1981 from 542 children under 14 years of age. the results of the study showed convincingly that influenza a(h2n2) viruses were not circulating in moscow in 1980-81. low titres found in the sera from four young children were due to cross-reactions which were eliminated from the sera by absorption with a/ussr/174/79(h3n2) virus. low-level hi ti ... | 1984 | 6609021 |
| antigenic structure of the hemagglutinin of influenza virus b/hong kong/8/73 as determined from gene sequence analysis of variants selected with monoclonal antibodies. | antigenic variation among influenza b viruses is different from that of influenza a in several ways. antigenic shift has not been observed, distinct antigenic variants of influenza b cocirculate, and antigenically similar viruses have been isolated many years apart. to study the mechanism of antigenic drift in influenza b viruses, monoclonal antibodies were used to select antigenic variants of b/hong kong/8/73 virus hemagglutinin (ha). analyses of the nucleotide sequences of the ha gene of b/hon ... | 1984 | 6083660 |
| [antigenic determinant composition of the hemagglutinins of influenza type b viruses isolated in 1940-1975]. | three antigenic determinants in influenza type b viruses hemagglutinin characterising similarities and differences between these viruses were found using monoreceptor sera. the viruses contained the following antigenic determinants: b/lee/40 b1, b2, b3; b/cri/49 b1, b2, b4; bm8/52 b1, b5, b6; b/60, 59 b1, b5, b7; b/victoria/70 b1, b5, b8, and b/hong kong/7/75 b1, b3, b8. | 1984 | 6083667 |
| [antigenic properties of the m1 proteins of influenza type b viruses and the detection of a common antigenic determinant of the m1 proteins of type a and b viruses]. | antigenic properties of m1 proteins of influenza b viruses were studied by indirect eia using monospecific antisera to m1 protein obtained by immunization of rabbits and mice. antisera with highest titres were obtained by immunization of mice with polyelectrolyte-conjugated m1 protein. antigenic heterogeneity of m1 proteins of influenza b viruses was demonstrated. m1 proteins of b/lee/40 and b/ussr/03/84 viruses reacted with b/hong kong/72 antiserum to one-fourth of the homologous titre. cross-e ... | 1984 | 6084897 |
| detection of respiratory virus antigens in nasopharyngeal secretions from patients with acute respiratory disease by radio-immunoassay and tissue culture isolation. | an investigation was made of the sensitivity and specificity of four-layer radio-immunoassays (ria) in the detection of adenovirus, respiratory syncytial virus, influenza virus types a and b, as well as para-influenza virus types 1, 2 and 3 from nasopharyngeal aspirates of 146 patients with acute respiratory disease. the sensitivity of ria was comparable with that of tissue culture isolation if the total number of positives is considered. the difference may have been caused both by a higher effi ... | 1984 | 6088961 |
| [antigenic relationships between influenza b/hong kong/72 strains and b/seattle/1/49]. | 1984 | 6090545 | |
| [antigenic anachronism of the influenza a(h2n2) viruses in leningrad in 1980. i. the epidemiological and serological characteristics of the influenzal infection caused by a/leningrad/80 (h2n2) viruses]. | in april-may 1980 a number of unrelated outbreaks of influenza-like diseases were registered in leningrad in an infant home (50 out of 68 children under observation, aged 3 months to 2 years, were affected) and among the pupils of a boarding school (13 out of 50 adolescents under observation, aged 15-17 years, were affected). 5 strains of influenza a virus were isolated from 3 sick children and 1 clinically healthy child. a similar virus was isolated from a sick adolescent in a boarding school, ... | 1984 | 6091375 |
| [influenza in moldavia (romania) in the winter and spring of 1985]. | 1985 | 3832279 | |
| [antiviral action of fractions isolated from propolis]. | 1985 | 3834770 | |
| [prospective epidemiologic study of the characteristics of the evolution of influenza in collectives of children and adolescents]. | 1985 | 3835657 | |
| [characteristics of virion formation during mixed infection with influenza viruses a and b]. | simultaneous infection of mdck cells with influenza a and b viruses at an equal multiplicity of infection leads to the synthesis of the proteins of both viruses. in the population of virions the hemagglutinin of influenza b virus prevails, whereas np proteins of both viruses are present in similar quantities. trypsin treatment of the double-infected cells resulting in the cleavage of the hemagglutinin molecules at the cell surface allows revealing the predominance of influenza b hemagglutinin on ... | 1985 | 3842740 |
| [character of the therapeutic action of different schedules of administration of donor anti-influenza gamma-globulin to influenza patients]. | 1985 | 3843155 | |
| [experience with the clinical use of donor anti-influenza gamma-globulin]. | 1985 | 3843156 | |
| epidemiology report: influenza 1984. national health laboratory, kenepuru. | 1985 | 3856765 | |
| enzyme immunoassay, complement fixation and hemagglutination inhibition tests in the diagnosis of influenza a and b virus infections. purified hemagglutinin in subtype-specific diagnosis. | the efficacy of enzyme immunoassay (eia) in detecting diagnostic antibody rises to influenza a and b viruses was compared with complement fixation (cf) and hemagglutination inhibition (hi) tests in 455 patients with an acute respiratory infection. eia and hi detected significantly more diagnostic antibody rises against influenza a than the cf method (96 and 87 vs. 47, respectively). in the case of influenza b significantly more diagnostic influenza b antibody rises were observed by eia than by c ... | 1985 | 3882733 |
| [epidemiology of influenza since 1968]. | 1985 | 3884531 | |
| ribavirin small-particle aerosol treatment of infections caused by influenza virus strains a/victoria/7/83 (h1n1) and b/texas/1/84. | in a double-blind study of influenza in a population of college students in 1984, ribavirin small-particle aerosol treatment of 38 patients (18 treated, 20 control) infected with a new antigenic variant, influenza virus strain a/victoria/7/83 (h1n1), was associated with statistically significant reductions in the height and duration of fever, systemic symptoms, and virus shedding. patients received a total of 2.4 g of ribavirin over 42 h during 68 h of hospitalization without any side effects. i ... | 1985 | 3888102 |
| [possibilities for spring vaccination of schoolchildren against influenza]. | 1985 | 3904287 | |
| influenza vaccination in dialysis and transplant patients. | 1985 | 3909959 | |
| [isolation of the internal proteins of the influenza virus by preparative polyacrylamide gel electrophoresis for obtaining monospecific antisera]. | the principal possibility of isolation of internal proteins (m and np) of influenza type a (h1n1 and h3n2) and b viruses by sds-pag preparative electrophoresis and preparation of monospecific antisera to these proteins was demonstrated. the resulting preparations may be used for testing the biological objects by enzymeimmunoassay. | 1985 | 3913133 |
| [use of immunoenzyme analysis to study the immune response of persons inoculated with influenza vaccines and in convalescents]. | 1985 | 3913138 | |
| [anti-influenza vaccination in children]. | due to new methods, including genic recombination, four anti-influenza vaccines are now available: whole inactivated virus vaccine; surface antigen (sub-unit); disrupted virus (split virus); live attenuated virus (used only in the ussr). the safest vaccine at the present time is the split vaccine, as it has been used on large populations (including children) for many years in japan. moreover, this is the only vaccine used in the usa on children (over three years of age). systemic side effects of ... | 1985 | 3915545 |
| [comparative antigenic analysis of the hemagglutinin from influenza b viral strains isolated in 1980-1981]. | 1985 | 3916952 | |
| [the etiologic role of influenza a and b viruses in acute respiratory infections and the status of population immunity to them in residents of kharkov]. | 1985 | 3917192 | |
| update: influenza activity--united states. | 1985 | 3919269 | |
| [use of immunoenzyme analysis for the detection and differentiation of influenza viruses a, b and c]. | test systems for elisa, containing antibodies to internal or supercapsid proteins and intended for the detection and differentiation of influenza a, b and c viruses in small amounts, have been developed. the possibility of using these systems for the determination of viruses both in material obtained directly from humans and in chick embryo isolates has been demonstrated. | 1985 | 3920848 |
| influenza--united states, 1984-1985 season. | 1985 | 3925319 | |
| national reye syndrome surveillance, 1982. | despite the fact that influenza b was the primary influenza virus strain during the winter of 1981-1982, only 213 cases of reye syndrome were reported to the centers for disease control (cdc) between dec 1, 1981 and nov 30, 1982. this national reported incidence of 0.33 cases per 100,000 children less than 18 years of age is the lowest reported incidence since the centers for disease control began surveillance in 1973. this relatively low incidence probably reflected, at least in part, the fact ... | 1985 | 3969325 |
| antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine. | the serum antibody responses and 50% protective levels (pl50) of antibody were determined, using the srh test, at one and twelve months post-vaccination in a group of student volunteers immunized with one of three dosages of a trivalent surface-antigen influenza virus vaccine, or with placebo. it was found that, for the h3, h1 and b haemagglutinin components present in the vaccine, a dose of 6 micrograms ha elicited high serum antibody responses at one month post-immunization. high mean antibody ... | 1985 | 3973383 |
| fulminant pneumonia caused by concomitant infection with influenza b virus and staphylococcus aureus. | 1985 | 3973782 | |
| characterization of a porcine kidney cell line resistant to influenza virus infection. | a mutant cell line of porcine kidney cells that resists the cytopathic effect of influenza virus has been obtained and characterized. these cells, designated esk-r, were originally obtained by prolonged cultivation of cells surviving influenza b/kanagawa/73 virus infection. no infectious virus was recovered from esk-r cells, and no evidence for the presence of virus antigens in the cells was demonstrated by immunofluorescent staining. esk-r cells also showed a distinct resistance to various othe ... | 1985 | 3973972 |
| influenza and mania: a possible connection with the locus ceruleus. | i have presented a possible case of mania induced by influenza b. some epidemic influenza viruses may be neurovirulent. these epidemics seem to be associated with postencephalitic parkinson's disease, mania, and depression. viral, neuroanatomic, neurophysiologic, neurochemical, pharmacologic, clinical, and epidemiologic evidence can be found to suggest a connection between the locus ceruleus, the influenza virus, and the induction of a manic psychosis. | 1985 | 3975719 |
| behaviour of influenza virus point-inoculated onto the mucous membrane of the chick tracheal explant. | influenza virus was point-inoculated on to the chick tracheal mucous membrane cultivated on a solid medium (l-15 agar medium) with a platinum microloop (ca 0.03 microliter of inoculum). following the rapid adsorption of the inoculated virus on the mucosal surface, the explant was infected with a high efficiency. the 50% minimal explant infectious doses (meid50) of influenza a virus strains (a/pr8/34, a/kumamoto/79 and a/bangkok/79) were less than one pfu. influenza b virus (b/lee/40) was also ad ... | 1985 | 3986132 |
| [erythrocyte antibody diagnostic agents for determining the type and subtype of influenza viruses]. | the method of antibody sensitization of sheep erythrocyte using amidole was employed to prepare diagnosticums for influenza a/ussr/090/77 (h1n1), a/bangkok/1/79 (h3n2), and b/hong kong/75 viruses. comparison of the potency of diagnosticums obtained on the basis of hyperimmune influenza sera and immunoglobulin preparations demonstrated that the use of globulins isolated with ammonium sulphate, by gel filtration on sephadex g-200, and ion-exchange chromatography on deae-cellulose 32 gives a higher ... | 1985 | 3993001 |
| [serological and clinical studies on an epidemic of influenza type b]. | 1985 | 3998076 | |
| [characteristics of the glycoproteins of vaccinal strains of the influenza viruses solubilized by octyl-beta-d-glucopyranoside]. | the use of a nonionic detergent, octyl-beta-d-glucopyranoside (og), under optimal conditions is highly effective in selective solubilization of membrane proteins (glycoproteins) of influenza a and b viruses, including the strains currently recommended for polytype inactivated influenza vaccines. the yield of hemagglutinin was 84-90% of the initial level in the virion concentrate. the antigenic stability of hemagglutinin of the a/h3 subtype upon storage for over 2 years and the a/h1 subtype for a ... | 1985 | 4002689 |
| concurrent outbreaks of influenza a and influenza b. | during the winter of 1982 concurrent outbreaks of influenza a and influenza b occurred. the epidemiology and clinical features of 151 cases referred during this time are described, and patients are discussed according to age and presenting clinical syndrome: croup was the commonest presentation in young children, a typical influenza syndrome predominated in young adults, while older patients were more likely to have lower respiratory tract infection. there was no significant difference between t ... | 1985 | 4008920 |
| the hi test modified by ether treatment in the sero-epidemiological surveillance of influenza b. | ether-treated influenza b haemagglutination inhibition (hi) antigen was used in a study of serum collections from three different epidemic seasons. for diagnostic purposes, ether treatment increased the efficacy of the hi test by about 50% over the conventional hi technique, raising it to the same level of sensitivity as the complement fixation (cf) test. the treatment reduced the specificity of the hi test, but its reliability in the diagnosis of influenza b infections was only slightly diminis ... | 1985 | 4008921 |
| molecular epidemiology of influenza virus: antigenic and biochemical analysis of influenza virus outbreaks in schools. | 1985 | 4013412 | |
| [immunologic reactions following influenza virus vaccination]. | 1985 | 4013413 | |
| tecumseh study of illness. xiii. influenza infection and disease, 1976-1981. | the occurrence of influenza was followed in tecumseh, michigan during the five year period 1976-1981 by identifying onset of acute respiratory illness and by virus isolation and serology. type b outbreaks were observed in 1976-1977 and 1979-1980, type a (h3n2) in 1977-1978 and 1980-1981, and type a (h1n1) viruses in 1977-1978, 1978-1979, and 1980-1981. evidence of low level circulation of viruses in the year preceding an outbreak was not obtained. age-specific isolation rates from specimens coll ... | 1985 | 4014174 |
| etiology of community-acquired pneumonia in patients requiring hospitalization. | the etiology of community-acquired pneumonia was studied in 127 patients with roentgenologically verified pneumonia who needed hospitalization. etiology was determined on the basis of a positive blood culture and/or a significant antibody titer increase. streptococcus pneumoniae was the probable etiological agent in 69 patients, nontypeable haemophilus influenzae in five patients, streptococcus pyogenes in two patients, and legionella pneumophila and staphylococcus aureus in one patient each. ev ... | 1985 | 4018066 |
| the ferret as a model for inner ear research. | viral infections have long been suspected to be causative agents in a number of inner ear dysfunctions. with few exceptions, the virus has not been demonstrated as the direct agent leading to hearing loss and/or vertigo. selective inner ear changes have been observed recently in sensory and nonsensory epithelial cells in the ferret model for reye's syndrome after intranasal inoculation with influenza b combined with aspirin administration and the creation of an arginine deficiency. such findings ... | 1985 | 4021437 |
| influenza surveillance at siriraj hospital: 1979-1983. | 1985 | 4031707 | |
| [monitoring of influenza in belgium, 1982-1983, 1983-1984]. | 1985 | 4037927 | |
| virions and intracellular nucleocapsids produced during mixed heterotypic influenza infection of mdck cells. | phenotypically mixed virus yields, obtained by coinfection of mdck cells with influenza a/wsn/33 and b/lee/40 viruses, contained both a/wsn/33 and b/lee/40 np proteins, as revealed by polyacrylamide gel electrophoresis of the purified 14c-amino acids-labeled virus. virions were lysed with 0.6 m kcl-triton x-100 buffer, and nucleocapsids were immunoprecipitated with antibodies against np protein of influenza a virus. polyacrylamide gel electrophoresis of the immunoprecipitate revealed np protein ... | 1985 | 4038521 |
| [enhancement of the immune response to surface antigens of the influenza b virus as a result of their covalent binding with a synthetic polymer carrier]. | the primary immune response (the number of antibody-forming cells, afc) and the delayed type hypersensitivity (dths) were studied in mice immunized either with isolated glycoproteins of influenza virus (hemagglutinin, ha and ha plus neuraminidase, ha plus na) or with their conjugates with an acrylic acid copolymer (cp) and n-vinylpyrrolidone of equimolar composition. immunization of mice with conjugates containing virus proteins (virogates-ha-cp or ha plus na-cp--entailed a 50-100 increment of t ... | 1985 | 4038611 |
| depressed chemiluminescence response by influenza virus is enhanced after conjugation of viral subunits to muramyl dipeptide. | the effect on respiratory burst of murine spleen cells after in vitro exposure to influenza virus, subunits, or subunits conjugated to muramyl dipeptide (mdp) was studied by luminol-dependent chemiluminescence (cl) in response to stimulation by zymosan. cl induced by infectious influenza a virus was depressed but could be elevated to normal levels when mdp was added together with a low, but not with a high, dose of the virus. profound depression of cl was induced by high doses of influenza a/bra ... | 1985 | 4044031 |
| influenza b and staphylococcal pneumonia. | 1985 | 4045624 | |
| electron microscopy of influenza virus. a comparison of negatively stained and ice-embedded particles. | an electron microscopical study was made of the influenza virus, type b/hong kong, in the unstained, frozen, hydrated state after quench-freezing in cooled liquid ethane. the results are compared with data from negatively stained specimens. it is shown that cryo-electron microscopy confirms and extends the data obtained by conventional methods. in particular, the virus is shown to be circular in projection with no indication of icosahedral symmetry, the lipid membrane is clearly resolved as a bi ... | 1985 | 4046029 |
| [isolation of the influenza b virus in mdck cells]. | the frequency of influenza b virus isolation from clinical specimens is much higher when a continuous line of dog kidney cells, mdck, is employed, and not the developing chick embryos. among 9 influenza b virus strains isolated during the influenza epidemic of 1983-1984 winter, 8 strains were isolated in mdck cells and only 1 in chick embryos. the influenza b virus isolates were similar to influenza b/singapore/222/79 virus differing from it in hi titres 2-16-fold. | 1985 | 4049838 |
| [detection and identification of the influenza virus in nasopharyngeal washings by solid-phase radioimmunological analysis]. | in the period of epidemic rise of the morbidity level in 1983-1984, 207 specimens of nasopharyngeal washings from patients with influenza were analysed by solid-phase radioimmunoassay. test sera containing a wide range of antihemagglutinating antibodies to different drift variants of influenza type a and type b viruses were used as diagnostic ones. the results indicate the predominance of influenza b infection (18.4%). influenza a accounted for 14.5%, 9.2% of it being subtype h1n1. noteworthy is ... | 1985 | 4049839 |
| [comparative evaluation of the therapeutic effectiveness of virazole and remantadine in patients with influenza caused by a(h3n2) and b viruses]. | therapeutic effectiveness of virazole in treatment of patients with influenza caused by a (h3n2) and b viruses (1980-1984) was demonstrated in 432 patients with the laboratory-confirmed diagnosis of influenza. provided the treatment started on the 1st day of the disease, the experimental group showed normalization of fever and regression of toxicity symptoms within shorter periods than the controls. however in treatment of patients with influenza caused by a (h3n2) virus virazole showed a less m ... | 1985 | 4049841 |
| [circulation of the influenza virus on poultry-raising farms]. | the results of examinations for immunity to influenza in chickens and the personnel handling them at the permanently observed farm are presented. antibodies mainly to the same antigenic variants of human influenza viruses were found in chicken and human blood sera. alongside with antihemagglutinins to influenza a (h3n2) virus strains, chicken in 1983-1984 were found to have antibodies to influenza b virus epidemically important in those years. thus, in poultry farms human influenza viruses are i ... | 1985 | 4049842 |
| alterations in the hemagglutinin associated with adaptation of influenza b virus to growth in eggs. | in 1943 burnet reported on changes in the hemagglutinating properties of human influenza virus which occurred during adaptation of the virus to growth in chicken eggs. only recently has direct evidence been presented that these changes affect the antigenic properties of the virus. schild et al. (g. c. schild, j. s. oxford, j. c. dejong, and r. g. webster (1983), nature (london) 303, 706-709) demonstrated that egg adaptation of influenza b virus selects variants which are antigenically distinct f ... | 1985 | 4060580 |
| [demonstration and study of the internal proteins of the influenza b virus using solid-phase radioimmunological analysis]. | internal proteins of influenza b/ussr/14/80 virus retaining their antigenic and immunogenic activities were obtained by electrophoresis in 1% agarose. antisera to eluted np and m polypeptides were prepared. study of influenza b viruses isolated in 1940-1984, performed by solid-phase radioimmunoassay, revealed no differences in the antigenic properties of nucleoprotein and matrix protein, except in the b/yamagata/73 virus. | 1985 | 4060697 |
| protein and nucleic acid analyses of influenza c viruses isolated from pigs and man. | the virus-coded proteins and the genomes of influenza c virus isolates obtained from chinese pigs in 1981-1982 and of human influenza c virus strains isolated between 1947 and 1981 were compared. using sds polyacrylamide gel electrophoresis and one-dimensional peptide mapping we found the virus-coded proteins of the pig influenza c viruses to be similar to those of human influenza c virus strains. the sizes of the genomes of human and pig influenza c viruses were indistinguishable. genome analys ... | 1985 | 4060845 |
| sensitivity of ortho- and paramyxovirus replication to human interferon alpha. | replication of the influenza virus strains influenza ao/wsn (h0n1), fowl plague (hav1n1) and b-lee/40 (atcc) and the paramyxovirus, new castle disease virus (victoria) are highly sensitive to human interferon type alpha in madin darby bovine kidney cells. pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. the inhibition of the orthomyxovirus strains used in this study and new castle disease virus replication is mediated by ... | 1985 | 4069110 |
| dynamics of neutralizing secretory influenza antibodies after nasal administration of the nivgrip trivalent influenza vaccine. | the trivalent inactivated nivgrip influenza vaccine was administered by nasal route to 26 young adults; a matched control group was represented by 19 subjects who received a placebo. vaccination was followed by a higher proportion of rises in the level of neutralizing secretory antibodies (70-77%) than in that of serum hai antibodies (19-42%) to the three influenza strains contained in the vaccine. simultaneous rises in secretory antibody titers to three and two influenza antigens occurred in 50 ... | 1985 | 4071977 |
| viral and rickettsial etiology of an outbreak of acute respiratory tract infection. | an outbreak of 111 cases of acute respiratory tract infection was recorded in a community of the town "t" in april-may 1984. the clinical picture was severer than usual; 28% of the cases had to be hospitalized, average absenteeism being as high as 26 days per case. serological investigations demonstrated the previous circulation of influenza virus b/singapore/222/79 and the simultaneous circulation during the outbreak of influenza virus a/england/333/80 (h1n1) and of rickettsia burneti (as also ... | 1985 | 4071978 |
| influenza b virus model of reye's syndrome in mice: the effect of aspirin. | aspirin is a possible cofactor with influenza b virus in reye's syndrome. in an attempt to determine whether single or multiple doses of acetylsalicylic acid (asa) alter mortality in an influenza b virus mouse model of reye's syndrome, either asa (300 to 667 mg/kg) or saline was given intraperitoneally to 3-week-old balb/c mice. two hours later, one median lethal dose (ld50) of influenza b/lee virus was given intravenously. mortality was not significantly increased by the single asa dose. blood ... | 1985 | 4073851 |
| activity of selenazofurin against influenza a and b viruses in vitro. | activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza a and b viruses. in experiments with madin darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza a/nws/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [vr], 1.3 to 1.4). the 50% effective dose range for ribavirin was 1.2 to 1.6 micrograms/ml (vr, 1.0 to 1.3), and for amantadine it ... | 1985 | 4073860 |
| synthesis of adenylyl-(3'----5')-guanosine and some analogues as probes to explore the molecular mechanism of stimulation of influenza virus rna polymerase. | influenza virus mrna synthesis is primed by a capped oligonucleotide which is cleaved off from a cellular mrna by a viral protein. the dinucleotide a3'p5'g can be used as a primer for the viral rna polymerase mediated rna synthesis in a cell-free system. analogues of a3'p5'g have therefore been synthesized using the phosphotriester approach, and their priming ability for the influenza virus mrna synthesis has been determined. an absence of the 2'-hydroxyl function in the guanosine residue in the ... | 1985 | 4082842 |
| structure and composition of influenza virus. a small-angle neutron scattering study. | a detailed analysis is presented of the small-angle neutron scattering curves of homogeneous solutions of influenza b virus, both intact and after treatment with bromelain, which removes the external glycoprotein spikes. the two sets of data are consistent with the following low-resolution structure: the virus particles are spherical, about 1200 a in diameter and of mr about 180 x 10(6). the lipid bilayer is centred at a radius of 425 a, is 40 a to 50 a thick and constitutes 25% to 28% of the vi ... | 1985 | 4093979 |
| [mobility study of influenza c virus proteins in cellulose acetate electrophoresis]. | four strains of influenza c virus were studied by cellulose acetate electrophoresis. all of them were found to contain super-capsid proteins destroyed by electrophoresis apparently due to contact with sodium dodecylsulphate. according to laver's classification, influenza c viruses may be placed with group 3 viruses. among major virion proteins of influenza c viruses matrix protein was found to be the most stable forming a separate protein band on cellulose acetate, and it may be readily identifi ... | 1985 | 4095974 |
| [biochemical indices of the allantoic fluid of chick embryos infected with the influenza virus]. | virus-containing allantoic fluid (vcaf) serves as raw material for influenza virus manufacture in the ussr. vcaf composition varies greatly from batch to batch. the causes of instability of its composition were studied. the main high molecular admixtures determining vcaf instability were found to include proteins and lipids getting into vcaf with amniotic fluid, blood, and yolk of the embryo when vcaf is collected. physicochemical characteristics (ph, protein and lipid concentrations, protein co ... | 1985 | 4095975 |
| [relation between features of the clinical course of influenza and the dynamics of the epidemic process]. | 1985 | 2951900 |