Publications

prevention of experimental equine encephalomyelitis in guinea pigs by means of virus adsorbed on aluminum hydroxide.		1934	17821750
variations in the cortical lipoid of the guinea-pig suprarenal with sex and age.		1934	17104517
on the genetics of subnormal development of the head (otocephaly) in the guinea pig.		1934	17246734
an analysis of variability in number of digits in an inbred strain of guinea pigs.		1934	17246735
the results of crosses between inbred strains of guinea pigs, differing in number of digits.		1934	17246736
further studies on the survival time of the bovine tubercle bacillus in soil, soil and dung, in dung and on grass, with experiments on feeding guinea-pigs and calves on grass artificially infected with bovine tubercle bacilli.		1934	20475242
a free growth period of tubercle bacilli in the guinea pig omentum as related to the hypersensitive state.		1934	19970176
comparative studies on the viruses of vesicular stomatitis and equine encephalomyelitis (1).	we have studied certain properties, additional to those previously described (3), of the virus of vesicular stomatitis of horses, and of the characteristic biological reactions of the virus of equine encephalomyelitis. it has been found that the virus of stomatitis, ordinarily dermotropic, can acquire neurotropism and the neurotropic encephalomyelitis virus can, in turn, be rendered dermotropic in its action. the neurotropism in both instances is associated with definite, although not pronounced ...	1934	19870237
the problem of the significance of the inclusion bodies found in the salivary glands of infants, and the occurrence of inclusion bodies in the submaxillary glands of hamsters, white mice, and wild rats (peiping).	1. acidophilic intranuclear inclusion bodies occur in the salivary glands of chinese infants dying from miscellaneous causes. the lesion is similar to that previously described in infants in europe and america. 2. attempts to prove that this lesion is due to an infectious agent by its production in animals have been unsuccessful. 3. acidophilic intranuclear inclusion bodies have been found in the submaxillary glands of hamsters, white mice, and wild rats. 4. evidence is presented to show that th ...	1934	19870337
acute ascending myelitis following a monkey bite, with the isolation of a virus capable of reproducing the disease.	a case of acute ascending myelitis which followed the bite of an apparently normal macacus rhesus monkey is described. the clinical course as well as the pathological changes has been studied and found to be suggestive of a virus cause for the disease. the absence of perivascular demyelinization removes the case from the realm of acute disseminated encephalomyelitis and establishes it more or less definitely as a primary acute infectious myelitis. an extremely important feature of the pathologic ...	1934	19870235
experiments on the conversion of typhus strains.	two types of strains of typhus virus are observed in mexico: first the murine type which is obtained from wild rats in nature, from isolated endemic cases, and from cases during short epidemic outbreaks, and second, the epidemic type of strains which is obtained from long standing serious epidemics. some of these epidemic strains correspond entirely to strains of historic old world typhus. other strains which in their experimental behavior are intermediate between these two types of strains were ...	1934	19870236
the histology of equine encephalomyelitis.	the virus of equine encephalomyelitis (eastern strain) evokes in the horse, calf, sheep and dog an unusually intense encephalomyelitis characterized by acute primary degeneration of nerve cells, the appearance in neurons of the brain stem and elsewhere of nuclear inclusions resembling those in borna disease and poliomyelitis, polymorphonuclear infiltration in the nervous tissues with early microglial proliferation, and perivascular cuffing with mononuclears and polymorphonuclears in varying prop ...	1934	19870264
a thermoprecipitation reaction in trypanosoma equiperdum infection in laboratory animals.	there is a thermoprecipitinogenic substance in extracts of the spleen of rats, guinea pigs and rabbits infected with t. equiperdum. it does not appear to be within the body of the trypanosome itself. antibodies to this heat-resistant precipitable substance were found in the serum of infected animals. the antibody strength seems to be relatively less in the serum of rats than in the other animals but the power of extracts from the spleen of infected rats appeared to be equivalent to the power of ...	1934	19870323
hemorrhages in skin lesions of guinea pigs following intravascular injection of toxins (shwartzman phenomenon).	1. filtrates from b. coli, b. typhosus, or meningococci injected into the skin of guinea pigs do not produce visible inflammation. when these injections are followed by intravascular injections of the same material, hemorrhages do not occur in the skin. 2. guinea pigs sensitized to horse serum react with redness and edema to 0.1 or 0.01 cc. of horse serum injected into the skin, and subsequent intravascular injection of typhoid filtrate does not produce hemorrhage at the site of the reaction to ...	1934	19870330
hemorrhages in tuberculous guinea pigs at the site of injection of irritants following intravascular injections of injurious substances (shwartzman phenomenon).	1. when toxic filtrates from cultures of b coli, b. typhosus, or meningococci are injected into the blood stream, peritoneal cavity, or subcutaneous tissue of tuberculous guinea pigs, the skin at the site of a tuberculin reaction becomes hemorrhagic. the extent of the hemorrhage is proportional to the severity of the tuberculin reaction demonstrable by tests with various dilutions of tuberculin. 2. tuberculin does not prepare the skin of non-tuberculous guinea pigs for this hemorrhagic reaction. ...	1934	19870331
studies on typhus fever : xii. the passive immunization of guinea pigs, infected with european virus, with serum of a horse treated with killed rickettsia of the mexican type.	under uniform diet conditions the normal bile fistula dog will eliminate pretty constant amounts of cholesterol-about 0.5 to 1.0 mg. cholesterol per kilo per 24 hours. diets rich in cholesterol (egg yolk) will raise the cholesterol output in the bile but compared to the diet intake (1.5 gm. cholesterol) the output increase in the bile is trivial (5-15 mg.). calves' brains in the diet are inert. bile salt alone will raise the cholesterol output in the bile as much and often more than a cholestero ...	1934	19870259
further observations on pathologic similarities between experimental scurvy combined with infection, and rheumatic fever.	in the guinea pig, chronic scurvy with superimposed infection (beta streptococcus) and to a lesser extent chronic scurvy alone, produces an arthropathy with striking pathologic similarities to that of rheumatic fever and the closely allied condition of rheumatoid arthritis. considerable significance is attached to the widespread occurrence in the experimental animal subjected to scurvy and infection, and to a lesser extent in scurvy alone, of lesions similar to if not identical with the fibrinoi ...	1934	19870234
effect of prolonged administration of acid extract of anterior pituitary on the thyroid gland of guinea-pigs.		1934	20778628
a mutation of the guinea pig, tending to restore the pentadactyl foot when heterozygous, producing a monstrosity when homozygous.		1935	17246747
the sex difference in the proportion of the suprarenal cortex occupied by lipoid in guinea-pigs over one year old.		1935	17104565
a colloidal dye effective in treating pernicious anemia and evoking reticulocytosis in guinea pigs.		1935	17811946
the ascorbic acid content of the intestine of the guinea-pig.		1935	16745635
the response of the isolated uterus of the guinea-pig to histamine.		1935	16745761
effect of androsterone and of male hormone concentrates on the accessory reproductive organs of castrated rats, mice and guinea-pigs.		1935	16745809
the effect of parathyroid hormone and of tuberculosis on the serum and tissue calcium of guinea-pigs.		1935	16745883
studies in fat metabolism: the oxidation of butyric, crotonic and beta-hydroxybutyric acids in presence of guinea-pig liver slices.		1935	16745890
the assay on guinea pigs of the hematopoietic activity of human livers, normal and pernicious anemia.		1935	16694339
the development of pure cultures of fibroblasts from single mononuclear cells.	1. most isolated guinea pig mononuclear exudative cells in tissue culture become typical migrating macrophages, but a small proportion take on fibroblastic characteristics, and produce pure colonies of fibroblasts. these fibroblasts maintain their morphological characteristics through repeated subcultures. 2. it is suggested that the subsequent development of individual mononuclear cells in tissue culture is conditioned at the time of explantation. 3. apposition with other cells is not necessary ...	1935	19870357
primary serum toxicity as demonstrated by the chicken embryo.	1. the 3 day old chicken embryo removed from its shell is a suitable test object for the demonstration of primary serum toxicity. addition of normal rabbit type sera as well as forssman antiserum causes the vascular network to contract and the embryo sinks in the yolk and dies. 2. only sera of animals of the so called rabbit type produce this phenomenon. sera of the guinea pig type are ineffective. 3. heating to 51 degrees c. destroys the complement content of normal human serum as also its effe ...	1935	19870374
encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys.	the repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (macacus rhesus). eight, control monkeys remained well. cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white ...	1935	19870385
multiplication in vitro of pseudorabies virus in the testicle tissue of immunized guinea pigs.	pseudorabies virus was cultivated in vitro in washed testicle tissue from immune guinea pigs, and evidence was thus procured which indicated that the testicle cells themselves had not become immune to pseudorabies. the rate of multiplication of the virus was considerably greater in control cultures with normal guinea pig testis than in cultures with immune testis. the reason for this fact may be that even by repeated washing the immune tissue could not be completely freed from fluid antibodies, ...	1935	19870393
pathogenic organisms of the genus listerella.	from meningitis in man, encephalitis in cattle and sheep, a myocardial infection in fowl, and a generalized infection in rabbits, different observers have isolated gram-positive organisms which are closely related. their cultural and serological properties are described. when injected intravenously into chickens, rabbits, or guinea pigs there is an unusual blood response, the monocytes being markedly increased. the organisms tend to localize in the myocardium with resulting necrosis.	1935	19870409
the degree of dispersion of the bacillus as a factor in infection and resistance in experimental tuberculosis.	1. the skin lesions in rabbits and guinea pigs following intradermal injection of tubercle bacilli (5 strains) were greatly increased in size and severity when testicle extract was added to the inoculum. such enhancement was followed by a more widespread and rapidly progressing disease only when virulent strains were employed. 2. attempts to suppress the development of skin lesions resulting from the injection of either normal or tuberculous rabbits with very small quantities of tubercle bacilli ...	1935	19870401
the transmission of equine encephalomyelitis virus by aedes aegypti.	in confirming kelser's work on the transmission of equine encephalomyelitis of the western type by aëdes aegypti it has been learned that the mosquitoes must be fed virus of high titer if positive results are to be secured. a period of from 4 to 5 days after feeding either on infected guinea pigs or on brain containing virus must elapse before the disease is transmitted by biting, but after this time transmission regularly results for a period of about 2 months. by inoculation, virus can be demo ...	1935	19870442
further studies on the submaxillary gland viruses of rats and guinea pigs.	1. it has not been possible to increase the virulence of the submaxillary gland viruses of guinea pigs and rats, either by reducing the resistance of the animals by exposure to x-ray, or by the addition of testicular extract (duran-reynals factor). 2. in guinea pigs and wild rats with spontaneously infected submaxillary glands, the kidney has been found to contain the virus in the absence of demonstrable pathological changes. 3. direct injection of these viruses into the kidney produces only mil ...	1935	19870449
the colony morphology of tubercle bacilli : i. the presence of smooth colonies in strains recently isolated from sources other than sputum.	1. smooth, round, shiny, non-granular, and non-spreading colonies have been observed in cultures of virulent tubercle bacilli freshly isolated from eight human sources other than sputum. the classification of six of these strains as of human type was established by inoculation into rabbits and guinea pigs. 2. the 3 per cent naoh or 6 per cent h(2)so(4) frequently used in the isolation of tubercle bacilli are definitely unfavorable to the development of smooth colonies. 3. it was observed that sm ...	1935	19870367
cortin protection against anaphylactic shock in guinea pigs.	studies have been made on a possible protective action of cortin in the prevention of anaphylactic shock induced by crystallized egg albumin. of sixteen control guinea pigs only two survived. sixteen of thirty-three cortin-treated animals received hormone at the optimum period of from 2 to 6 hours before the shocking dose. nine survived and two others showed some protection. in groups treated at other time intervals the evidence of protection is inconclusive. 2 weeks after the first test the cor ...	1935	19870348
studies on anaphylaxis with pollen.	1. guinea pigs injected intracutaneously and subcutaneously with extract of the pollen of burweed marsh-elder in relatively small amounts did not show anaphylactic response to intravenous shock doses of this material 3 weeks later. 2. if, however, the animals were sensitized with horse serum either before, or along with the same pollen injections, they could then be shocked after an interval of 3 weeks with pollen extract alone. 3. the possible rôle of this underlying sensitivity is discussed.	1935	19870350
on the preservation of typhus fever rickettsiae in cultures.	1. cultures of typhus fever rickettsiae were as a rule found to remain viable and virulent after being stored at 37 degrees and -20 degrees c. for several months, whereas they failed to survive when stored at the intermediate temperatures of 20 degrees and -4 degrees c. for 4 weeks and 10 days respectively. in one instance cultures were stored at 37 degrees c. for 8 months without having been transferred, and were subsequently found to be viable and infectious. 2. the conditions influencing such ...	1935	19870343
the phenomenon of local skin reactivity to bacterial filtrates: elicitation of local reactivity by way of the vascular system.	the skin of the rabbit's ear is considerably more resistant than the abdominal skin to the phenomenon of local skin reactivity to bacterial filtrates. ten times the provocative dose is required if it is given into the vein of the prepared ear and thirty times the provocative dose if it is given into the vein of the non-prepared ear. the state of reactivity cannot be elicited by a preparatory intravenous injection of bacterial filtrates alone into clamped and non-clamped ears. the state also fail ...	1935	19870438
the colony morphology of tubercle bacilli : iii. the relation between virulence and colony form.	all the strains of human tubercle bacilli described in this report as recently isolated from clinical cases proved to be virulent and showed but slight differences in pathogenic properties. neither did they show extreme variation in virulence when compared with strain h-37, isolated many years ago. between twelve bovine strains cultivated in vitro for varying periods, there was a much wider range in virulence, some being so attenuated as to give regressive lesions in both rabbits and guinea pigs ...	1935	19870439
experimental studies on encephalitis : ii. the specific virus character of the infectious agent from cases of st. louis and kansas city encephalitis, 1933.	1. the infectious agent from fatal cases of st. louis and kansas city encephalitis passes seitz pads in high dilution without appreciable loss of infectivity and traverses collodion membranes with an average pore size of 66 mmicro or greater. 2. it is highly infectious for mice by the intracerebral and intranasal routes, but practically innocuous by the subcutaneous and intraperitoneal routes. 3. certain strains of mice are more susceptible than others. 4. the agent administered to mice intranas ...	1935	19870368
studies on the sensitization of animals with simple chemical compounds.	experiments on the sensitization of guinea pigs with simple chemical compounds are described. positive effects were obtained by the administration of small quantities, namely fractions of milligrams, with 1:2:4 chlorodinitrobenzene, p-nitrosodimethylaniline, 1:2:4 trinitrobenzene, picryl chloride, four dichlorodinitrobenzenes, and a number of other aromatic compounds. several substances chemically similar to those enumerated gave negative results. the first named compound is known to produce hyp ...	1935	19870383
histological effects of potassium iodide and thyroid substance on the thyroid gland of the guinea pig in experimental scurvy.		1935	19970210
corneal reactions of normal and of tuberculous guinea pigs to tuberculo-protein and tuberculo-phosphatide.		1935	19970242
experiments confirming the antiscorbutic activity of dehydroascorbic acid and a study of its storage and that of ascorbic acid by the guinea-pig at different levels of intake.		1936	16746006
the selective absorption of ascorbic acid by guinea-pig tumour tissue.		1936	16746145
vitamin c requirements of the guinea-pig.		1936	16746174
cataract and ascorbic acid in the guinea-pig eye.		1936	16746175
the determination of vitamin c by means of its influence on the body weight of guinea-pigs.		1936	16746213
reticulocytosis in the guinea pig following injections of gastric juice and congo red.		1936	16694429
studies on tetanus toxoid: iii. antitoxic response in guinea pigs immunized with tetanus alum-precipitated toxoid followed by tetanus spores.		1936	16559926
the effect of antithyrotropic serum on the thyroid gland of guinea-pigs treated with thyrotropic hormone.		1936	16994730
the technique of suprarenalectomy in the guinea-pig and the survival period and cause of death of guinea-pigs after bilateral suprarenalectomy.		1936	16994818
the effect of certain hormones on the activity of the uterine muscle of the guinea-pig.		1936	16994827
mange in guinea pigs.		1936	17802421
bacteriologic experimentation on the guinea pig fetus.		1936	17740450
sulfocyanate treatment of mange in guinea pigs.		1936	17749388
ovum age and the course of gestation in the guinea pig.		1936	17742899
growth of the reproductive and endocrine organs of the guinea-pig.		1936	17104594
on the genetics of the spotted pattern of the guinea pig.		1936	17246818
[influence of hormones on the cervical glands].	in most laboratory animals (e.g. guinea pig, rat, rabbit) the appearance of the cervix is very variable, and is characterized by a glandular differentiation between the vagina and the body of the uterus. the author has tried to provoke variations in the glandular morphology of the cervix by injection of total folliculin, of ovarian lipids, corpus luteum extracts, purified folliculin, and synthetic proluton. in the guinea pig injection of folliculin first thickened the basal layers of the vagin ...	1936	12311508
intracerebral inoculation of fetal guinea pigs with bacille calmette-guérin and the h(37) strain of tubercle bacillus.		1936	19970257
ultracentrifugation of intranuclear inclusions in the submaxillary glands of guinea pigs and ground moles.		1936	19970301
susceptibility of the guinea pig fetus to vaccinia.		1936	19970258
the innervation of teeth: (section of odontology).	the author, using the staining methods of bielschowski, gross, beckwith, weigert-pal and cajal in frozen and serial paraffin and celloidin sections, has investigated the dental innervations of man, monkey, dog, cat, and guinea-pig in health and disease. he discusses the anatomy and physiology of the dental innervation and the effect of section of the inferior dental nerve on the trophic, vasomotor, protective, and sensory functions, with special reference to the relation between dental disease a ...	1936	19990651
an experimental investigation of the lymphatic system of the teeth and jaws: (section of odontology).	a review of the literature is given, followed by a consideration of the available methods of demonstrating the lymphatic system in the area of the teeth and jaws.a new method of demonstrating this system by the injection or application of lead acetate intra vitam, is described, and the technique is explained. the method can be employed to reveal macroscopic or microscopic lymph channels in any part of the body, and is especially of value where decalcification of the hard tissues has to be carrie ...	1936	19990818
susceptibility of the guinea pig fetus to the submaxillary gland virus of guinea pigs.		1936	19970259
studies of a paralysis syndrome produced in rabbits and guinea pigs by extracts of normal primate bone marrow.		1936	19970269
studies on inflammation : xii. mechanism of increased capillary permeability. a critique of the histamine hypothesis.	various types of inflammatory exudates have been obtained either by the introduction into normal tissues of a chemical irritant, or by a burn, or by bacteria in either dogs or rabbits. a study has also been made on an exudate of human origin. these exudates have all been found to contain a factor which induces prompt increase in the permeability of normal skin capillaries, demonstrable by the almost immediate accumulation from the circulation of trypan blue into areas of skin injected with the c ...	1936	19870549
active immunization of guinea pigs with the virus of equine encephalomyelitis : ii. immunization with formolized virus.	from a study by quantitative methods, the conclusion is reached that a resistance of high degree may be induced in guinea pigs and mice against experimental equine encephalomyelitis by means of formolized vaccines in which no active virus can be demonstrated. the induced resistance is not due to residual traces of active virus which might possibly have escaped detection in the formolized tissue preparations.	1936	19870501
persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity.	in some apparently healthy mice the virus of lymphocytic choriomeningitis persisted for a considerable period of time after recovery, in the blood, urine, and nasal secretions, while in other mice it soon became undemonstrable. it is possible that the persistence of the virus is due to lesions in the lungs, liver, and kidneys. the immunity to lymphocytic choriomeningitis in mice does not seem to depend upon the presence of virus in the blood and the organs tested. no antivirus was detected in se ...	1936	19870509
the protective action of nasally instilled immune serum against infection with certain neurotropic viruses by way of the nose.	1. immune serum instilled intranasally in guinea pigs has protected them from infection with lethal amounts of pseudorabies virus by the nasal route. the same effect was obtained in mice with immune serum against the virus of equine encephalomyelitis (eastern strain). 2. the protective effect of the immune serum in the nose begins at the time of instillation, is still evident 5 hours later, and usually has disappeared by the end of 24 hours. 3. attempts to prolong the local effectiveness of immu ...	1936	19870510
active immunization of guinea pigs with the virus of equine encephalomyelitis : iii. quantitative studies of serum antiviral bodies in animals immunized with active and inactive virus.	an analysis of the preceding experiments discloses that antiviral bodies are demonstrable not at all or in small amounts in the sera of guinea pigs injected with a quantity of active virus not sufficient to induce immunity against the described intracerebral test for induced resistance. however, neutralizing bodies are found in immune animals, although in low concentration, and are regularly manifested when serum is added to low multiples of infective doses of virus under optimal conditions of t ...	1936	19870531
active immunization of guinea pigs with the virus of equine encephalomyelitis : iv. effect of immune serum on antigenicity of active and inactive virus.	a study was undertaken on the effect in vivo, in the guinea pig, of equine encephalomyelitis virus antiserum upon the antigenic response to active, as compared with that to formolized, inactive virus. it was found that when animals were given subcutaneously a proper amount of hyperimmune serum 1 hour before inoculation, in the subcutis, of either active or of inactive virus, no immunity was induced against an intracerebral test of more than 1,000 and less than 10,000 m.l.d. of virus. this preven ...	1936	19870532
studies on the sensitization of animals with simple chemical compounds. ii.	in continuation of previous work sensitization experiments have been made with various substances such as urushiol, benzyl chlorides, and acyl chlorides. in the case of a series of substituted benzenes (cl, no(2)) a connection between sensitizing capacity and lability of the cl or no(2) groups has been shown, indicating the formation of conjugated antigens in the animal. this led to the study of benzyl and acyl chlorides which, actually, were found to have sensitizing capacity. most informative ...	1936	19870557
a skin test for detecting group c hemolytic streptococcal infection causing epizootic lymphadenitis in guinea pigs : applications in selecting breeding stock.	1. a skin test with a crude bacterial extract prepared from group c (lancefield) hemolytic streptococci was used as a means of detecting possible carriers of the streptococcus causing epizootic lymphadenitis in guinea pigs. a positive test similar to a positive tuberculin reaction was considered presumptive evidence of present or recent infection with this streptococcus. 2. 20 positive reactors were found in 330 supposedly normal guinea pigs. 3. 195 negatively reacting animals were used as a bre ...	1936	19870552
studies on the mechanism of immunity in typhus fever : i. rickettsia prowazeki in the different stages of the typhus lesion.	this study of the lesions produced in the skin of guinea pigs inoculated intracutaneously with mexican typhus virus, shows that there is an early polymorphonuclear response at the point of inoculation. as early as 24 hours after the virus is given, a mononuclear phagocytic infiltration, which is more pronounced around the larger vessels of the corium, vascularis, and muscularis, replaces the polymorphonuclear infiltration. the endothelial cells of capillaries and small vessels swell up, thus par ...	1936	19870561
studies on the mechanism of immunity in typhus fever : ii. allergic and toxic reactions produced with rickettsia prowazeki.	the intradermal inoculation of mexican typhus virus into immune guinea pigs produces a local reaction which is similar in its appearance to the lesion observed in the skin of normal animals submitted to the same treatment. the reaction in the immune animal appears earlier and fades sooner than the lesion in the normal guinea pig. the inoculation of heat-killed or formalin-killed rickettsiae produces no significant reactions at the site of the intradermal injection in typhus immune guinea pigs. t ...	1936	19870562
the relation between antianaphylaxis and antibody balance : ii. the effect of specific desensitization upon resistance to infection and upon antibody balance.	it has been shown that antianaphylaxis is not caused by a partial saturation of cellular or humoral antibodies by the following facts. 1. guinea pigs passively sensitized with anti-horse or antipneumococcus serum and specifically desensitized do not manifest as great a reactivity upon resensitization with the same antiserum as upon the original sensitization. 2. guinea pigs passively sensitized with anti-friedländer type b serum or antipneumococcus type ii serum and specifically desensitized do ...	1936	19870559
further studies on typhus fever : on homologous active immunization against the european strain of typhus fever.	1. guinea pigs can be actively immunized against european typhus fever with homologous formalinized rickettsia tissue cultures, provided sufficient amounts are injected. the method is suggested for practical application in man. 2. serovaccination against european typhus fever can be successfully applied to guinea pigs by a variety of methods, the simplest of which consists of the injection of mixtures of virulent defibrinated guinea pig blood and convalescent guinea pig serum taken from 3 to 5 d ...	1936	19870560
the relation between antianaphylaxis and antibody balance : i. the role of excess of circulating antibody in hypersensitiveness.	1. sensitized guinea pigs injected with normal rabbit or guinea pig serum previous to intravenous inoculation of antigen may be protected against a few lethal doses of antigen. the protection is greater with foreign than with homologous serum and appears to be related roughly to the amount of serum introduced. 2. sensitized guinea pigs injected with antibody-containing serum preliminary to intravenous injection of antigen, show no greater refractoriness to anaphylaxis than do those injected with ...	1936	19870558
studies on the etiology of rabbit pox : v. studies on species susceptibility to rabbit pox virus.	the white mouse, the guinea pig, the calf, and probably the rat, were found to be susceptible to infection with the virus of rabbit pox. serial transmission of the virus in mice by brain to brain passage was characterized by a fatal outcome usually on the 5th or 6th day after inoculation. infection of the guinea pig was accomplished by intratesticular injection and the virus was continued to the 2nd passage in this species. guinea pigs developed a well marked cutaneous reaction from the intrader ...	1936	19870484
tissue culture studies on bacterial hypersensitivity : iii. the persistence in vitro of the inherent sensitivity to tuberculin of cells from tuberculous animals.	1. mononuclear exudative cells, obtained from tuberculous guinea pigs by the intrapleural injection of parowax, exhibited characteristic sensitivity to the toxic action of tuberculin when tested in tissue culture. 2. experiments with these cells, practically free of body fluids, show conclusively that sensitivity to tuberculin is an inherent characteristic of mesenchymal cells from tuberculous animals. 3. fibroblastic growths which developed from mononuclear exudative cells derived from a tuberc ...	1936	19870579
studies on the sensitization of animals with simple chemical compounds : iii. anaphylaxis induced by arsphenamine.	experiments are described which show that with a given treatment guinea pigs can be sensitized to arsphenamine, so that a considerable percentage die in anaphylactic shock on intravenous administration of the substance.	1936	19870563
an acquired resistance of growing animals to certain neurotropic viruses in the absence of humoral antibodies or previous exposure to infection.	1. as mice grow older they acquire a resistance to peripheral inoculation with the indiana and new jersey strains of vesicular stomatitis virus and to some extent also to western equine encephalomyelitis virus, but little or none to the eastern strain. 2. while some mice may become resistant as early as the 30th day of life, others may still be susceptible at 1 year of age. 3. this resistance is readily demonstrable when the inoculations are made by intranasal, subcutaneous, intramuscular, intra ...	1936	19870564
effect of pneumococcus autolysate antitoxin on pneumococcus pneumonia in guinea pigs.	1. in rabbits, guinea pigs, and mice pneumococcus autolysate antitoxin has no effect against generalized infection by the pneumococcus. 2. in a large proportion of cases of pneumonia and sepsis caused by the intratracheal inoculation of large amounts of living pneumococci in normal or sensitized guinea pigs, autolysate antitoxin saves the animal. 3. the autolysate antitoxin is protective in most cases of pneumonia and sepsis caused by the intratracheal inoculation of small amounts of living pneu ...	1936	19870580
active immunication of guinea pigs with the virus of equine encephalomyelitis : i. quantitative experiments with various preparations of active virus.	active eastern or western equine encephalomyelitis virus in three forms,-chemically untreated but simply passaged through series of mice; adsorbed on alumina gel c, and precipitated by tannin,-yielded practically the same results when employed for the immunization of guinea pigs. the virus is not inactivated by the process of adsorption or precipitation : guinea pigs and mice inoculated in the brain with these materials develop lethal encephalomyelitis in the same manner as when chemically untre ...	1936	19870474
studies on culture strains of european and murine typhus.	1. a strain of european typhus (breinl) has been carried in cultures by means of successive transfers for a period of 1(1/2) years, the rickettsiae in such cultures being quite as numerous as in similar cultures of murine strains of typhus. 2. the virulence of the cultures of european typhus has remained constant throughout the period of cultivation, although, on the whole, the scrotal lesions caused by the later culture generations were somewhat less marked than those produced by the first gene ...	1936	19870476
an epidemic in a mouse colony due to the virus of acute lymphocytic choriomeningitis.	a filtrable virus, identical with that which causes acute lymphocytic choriomeningitis, has been found to cause a disease in white mice. naturally infected mice usually show no symptoms, but such animals inoculated intracerebrally with sterile bouillon or other materials develop characteristic symptoms. the same symptoms are produced by intracerebral injection of the virus into mice from a disease-free stock. guinea pigs are very susceptible and are therefore useful for detecting the virus and f ...	1936	19870488
tissue culture studies on bacterial hypersensitivity : ii. reactions of tissues from guinea pigs infected with group c hemolytic streptococci.	1. guinea pigs infected with naturally pathogenic hemolytic streptococci (group c-lancefield) develop a low grade chronic type of disease characterized chiefly by purulent lymphadenitis. 2. cutaneous hyperreactivity to a crude streptococcal extract invariably occurred during the course of this infection. 3. production of antibodies (precipitins and agglutinins) was studied. 4. the hemolytic streptococcal extract had a specific toxic effect, when tested in vitro, on cells from infected animals; t ...	1936	19870540
the standardization of longevity against dose in experimental tuberculosis by intracerebral inoculation.	intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. the disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. the disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. certain possible applications o ...	1936	19870568
the radiological demonstration of bronchial constriction in acute anaphylaxis in the guinea-pig.		1936	20475306
vaccination of guinea-pigs and human beings against leptospiral infections.		1937	20475377
immunological studies on pepsin and pepsinogen.	1. alkali (ph 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. similarly treated pepsins from the rabbit, chicken, and shark do not. 2. pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, nor with the serum proteins from the homologous species. positive reactions between activated pepsinogen ...	1937	19873029
studies in blood coagulation : v. the coagulation of blood by proteolytic enzymes (trypsin, papain).	crude or crystalline trypsin in proper concentration causes the blood or plasma of human beings, dogs, rabbits, guinea pigs, and horses to coagulate. it does not clot the fibrinogen directly, but reacts with prothrombin to form thrombin. since trypsin thus has the same effect as the physiological system ca plus platelets (or ca plus tissue extracts), it is suggested as a tentative working hypothesis that the latter system contains a proteolytic enzyme with a specific affinity for prothrombin. ot ...	1937	19873009
experimental local bladder edema causing urine reflux into ureter and kidney.	experimental infiltration of the intravesical ureter of the normal bladder in the living, anesthetized animal with magnesium sulfate or physiological salt solution caused a reflux of urine into the ureter in 6 out of 18 guinea pigs (33 per cent); in 22 out of 27 rabbits (81 per cent), and in 14 out of 17 dogs (82 per cent). the vesical pressure necessary to produce this experimental reflux is low and ranges between 2 and 12 mm. of hg; hydrostatic pressure of the bladder contents often sufficed t ...	1937	19870695
tissue culture studies on bacterial hypersensitivity : iv. protective effect of immune plasma against the deleterious influence of streptococcal extract on hypersensitive cells.	1. plasmas from guinea pigs, chronically infected with group c hemolytic streptococci, neutralize the components of bacterial extract which exert a marked toxic action on hypersensitive cells in vitro. 2. the neutralizing capacity of these immune plasmas is relatively specific for the bacterial extract, and is not due to a variable nonspecific effect on normal or hypersensitive tissue cells. 3. a rough correlation between the agglutinin titer and the relative neutralizing capacity of immune plas ...	1937	19870620
the effect of prolonged cultivation in vitro upon the pathogenicity of yellow fever virus.	1. experimental evidence is presented to show that prolonged cultivation of yellow fever virus in vitro results in a change in its pathogenicity, and that this change varies with the type of tissues used for the cultivation. 2. in the tissue cultures used for the propagation of the virus, three different types of tissues were used. they included whole mouse embryo, chick embryo from which the head and spinal cord had been removed, and testicular tissues of mice and guinea pigs. 3. the changes in ...	1937	19870633
studies on pulmonary edema : ii. the pathogenesis of neuropathic pulmonary edema.	1. guinea pigs die shortly after bilateral cervical vagotomy, even when continuous artificial respiration effected through a tracheal cannula is carried out. death is caused by severe pulmonary edema and congestion. 2. direct observation of the lungs after bilateral vagotomy demonstrates that pulmonary edema develops gradually and increases slowly in amount and severity. congestion precedes and accompanies the development of the edema. 3. neuropathic pulmonary edema in the guinea pig is caused b ...	1937	19870672