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effect of topically applied steroidal and nonsteroidal anti-inflammatory agents on skin repair and regeneration.we studied the effects of topically applied steroidal and nonsteroidal anti-inflammatory agents on dermal and epidermal wound healing. superficial wounds (0.3 mm deep) on the skin of domestic pigs were treated daily with either 0.1% triamcinolone acetonide (ta), 1% hydrocortisone (hc), 1% nandrolone decanoate (nd), 1% nd + 0.1% ta, 10 mg ibuprofen, 10 mg meclofenamate sodium, 3 mg indomethacin, vehicle (usp petrolatum or 70% ethanol), or control (untreated). wounds were excised on days 2-7 after ...19846207052
detecting arterial and venous obstruction in flaps.island skin flaps based on the latissimus dorsi muscle were raised in domestic pigs. flap circulation, maintained only by the vascular pedicle, was monitored by laser doppler flowmetry, laser photometry, and transcutaneously measured carbon dioxide tension. both arterial and venous occlusion were accompanied by very low laser doppler flow values. in laser photometry, the backscattered intensity of light remained unchanged or was slightly increased during arterial occlusion. in response to venous ...19853156550
effects of platelet-activating factor on coronary hemodynamics and coronary venous plasma levels of txb2, 6-keto-pgf1 alpha, and leukotriene c4 immunoreactivity in the intact domestic pig heart. 19853159202
streptozotocin diabetes in juvenile pigs. evaluation of an experimental model.spontaneous diabetes in the domestic pig, an animal suitable for metabolic and endocrine studies and for experimental surgery, is extremely rare. in this study we have compared the diabetogenic response of various doses of streptozotocin in comparison to surgically induced diabetes. streptozotocin in a low dose, 35 mg/kg body weight did not influence glucose metabolism while an intermediate dose, 85 mg/kg, resulted in a transient diabetic reaction. streptozotocin, 100-150 mg/kg body weight, caus ...19853160643
ultrastructure of the integument of the domestic pig (sus scrofa) from one through fourteen weeks of age. 19853161419
ultrastructure and topography of dense bodies in pinealocytes of castrated males of domestic pig. 19853836180
pharmacokinetics of chronic fluoride ingestion in growing pigs.the present study was undertaken to estimate bio-availability and biological half-life of fluoride and accumulation of fluoride in bone in the domestic pig. eight animals receiving 2 mg f-/kg b.w. per day from age 8 to 14 months were compared with eight controls. plasma fluoride concentrations just prior to the daily oral dose were measured at regular intervals. after 112 days post-dose, plasma fluoride levels were measured over a 48-hour period following the daily oral dose or a single intraven ...19853855893
[genetic and functional effects on fiber type composition and fiber diameters in the longissimus muscle of the thorax and the semitendinous muscle of swine. studies of exercised domestic swine and wild swine kept under restricted mobility]. 19853886351
lipid transport systems: some recent aspects in swine, cattle and trout during development.lipids such as triacylglycerols, free and esterified cholesterol and phospholipids are essentially insoluble in water; lipoproteins, which are complex macromolecules of pseudomicellar structure, have evolved to ensure their efficient transport in the vascular system of vertebrates. plasma lipoproteins are operationally classified according to their relative lipid and protein contents and thus according to density. the protein components, i.e. apolipoproteins, have a highly specialized structure ...19853887526
nucleoside transport and metabolism in erythrocytes from the yucatan miniature pig. evidence that inosine functions as an in vivo energy substrate.erythrocytes from the yucatan miniature pig, like those from the normal domestic pig, lack functional glucose transporters and were unable to utilize plasma glucose as an energy source. in contrast, inosine and adenosine entered the cells rapidly. the nucleoside transporter responsible for this uptake was identified as a band 4.5 polypeptide (5000 copies per cell; apparent mr 45 000-66 000). inosine concentrations in the physiological plasma range (1.6-2.5 microm) were found to maintain normal e ...19853902093
[animal experiment studies on the healing of bone transplants by clamping plate fixation following hyperthermic denaturation].the re-use of resident bone transplants after hyperthermic denaturalization is demonstrated in radiologically, clinically, and histologically in the lower jaw of the domestic pig. periosteal and enosteal osteogenic effect is induced.19853909673
influence of light and photoperiodicity on pig prolificacy.in the wild pig mating activity is seasonal. the main breeding period is in late autumn but a second period may occur around april. it is known from other species that seasonal variations in breeding activity are mainly regulated by photoperiod. in the domestic pig seasonal influences on prolificacy still exist: for example, ai boars not only show decreased steroid synthesis, sperm counts and libido in summer compared with the optima which occur in winter but also a biphasic pattern with a trans ...19853910824
the epidemiology of african swine fever: the role of free-living hosts in africa.the known distribution of african swine fever (asf) virus in africa is reviewed in relation to the distributions of its free-living hosts as are the infection rates of these species in different localities in southern africa. mechanisms by which asf virus is maintained in its sylvatic state and ways in which the infection may enter domestic pig populations are discussed.19853911134
[in vitro oxidation of [u-14c] palmitate, [1-14c] and [6-14c] glucose in newborn and adult rats and pigs].studies have been made on the intensity of oxidation of [u-14c]-palmitate, [1-14c]- and [6-14c]-glucose by slices of the liver and skeletal muscles of new-born, 1-day, 5-day and adult wistar rats and domestic pigs. it was found that the level of 14co2 production from these substrates is higher in tissues of rats than in those of pigs. at early stages of ontogenesis, in tissues of both species intensive oxidation of glucose is observed together with oxidation of fatty acids. in the course of onto ...19853920843
measurement by electrical impedance aggregometry of porcine platelets response to selected physiological agonists.although the domestic swine is commonly employed for physiological studies of the coronary circulation, there is relatively little data available concerning the responsiveness in whole blood of normal porcine platelets to standard physiological agonists. such information is essential if the domestic swine is to be used as an animal model for studying potential interactions between platelets and the coronary circulation. accordingly, the present study was undertaken to characterize the responses ...19853923491
chromosome mapping in domestic pigs (sus scrofa): mpi and np located to chromosome 7. 19853930426
chromosome mapping in domestic pigs (sus scrofa): pk is not linked to the syntenic group mpi-np on chromosome no. 7. 19853930427
regeneration of epidermis by cells grown in tissue culture.pig epidermal cells were grown in vitro for 21 to 180 days, forming multilayered sheets of epidermis varying from thirteen to forty layers. for an evaluation of their use in wound coverage, they were transplanted onto surgically prepared full-thickness wound beds on domestic swine. autologous epidermal cells were studied on twenty-five of the animals, and allogeneic epidermal cells were studied on thirteen. autologous epidermal cells grown in vitro provided functional wound coverage 10 to 15 day ...19853973141
effects of calcium entry blockers on coronary constriction and myocardial ischemia due to leukotriene d4.recent studies show that leukotrienes (lts) produce profound coronary artery constriction. although calcium entry blockers are commonly used to remedy coronary vasospasm, their capacity to interfere with lt-mediated coronary constriction is unknown. therefore, we compared effects of intracoronary ltd4 before and during treatment with calcium entry blockers in the in situ, blood-perfused hearts of domestic pigs. intravenous administration of verapamil (0.1-1.6 mg/kg), nifedipine (10 or 100 microg ...19853981457
notes on placentation in the suina.we examined the gross and microscopic anatomy of placental tissues and umbilical cords from six species representing the three living families of the suina. these species included, of the suidae, the wart hog (phacochoerus aethiopicus), the giant forest hog (hylochoerus meinertzhageni), the domestic pig (sus scrofa), and the banded pig of malaysia (sus scrofa vittatus); of the tayassuidae, the white-lipped peccary (tayassu pecari); of the hippopotamidae, the hippopotamus (hippopotamus amphibius) ...19853991477
group r streptococci: wild boars as a second reservoir.group r streptococci have caused many cases of septicaemia and meningitis in patients handling live or slaughtered pigs which were the only known reservoir of group r streptococci. a human case, due to a wild boar, is reported here and it is therefore concluded that there exist both a domestic (pig) and a wild (wild boar) reservoir of group r streptococci.19853992197
trichinella spiralis: acquired immunity in swine.the ability of domestic pigs to develop protective immunity to trichinella spiralis in response to inoculation with different doses of muscle larvae was assessed. adult worms developing from the inoculations of 112, 500, and 10,000 larvae were expelled from the intestine about 6 weeks after inoculation. inoculation with 25,000 larvae, however, resulted in more rapid intestinal worms expulsion, indicating that gut expulsion is dose dependent. secondary expulsion also tended to be dependent upon p ...19853996525
comparison of lung antioxidant levels in humans and laboratory animals.basal lung concentrations of ascorbic acid (aa), nonprotein sulfhydryls (npsh), and alpha-tocopherol (alpha-t) were determined in rabbits, guinea pigs, rats, hamsters, mice, domestic pigs and sheep, and in human lung samples obtained from cancer surgery patients. significant differences were found among the laboratory animals: aa levels ranged from 25.6 mg% (mg/100 g wet weight) in hamsters to 41.7 mg% in mice, npsh from 50.9 mg% in rats to 84.7 mg% in rabbits, and alpha-t from 1.01 mg% in hamst ...19854003918
histologic and temperature alterations induced by skin refrigerants.the histologic alterations induced by spray refrigerants independent of and in combination with dermabrasion were studied with the use of the domestic pig as a model. tissue injury was found to be a function of spray duration and freeze intensity. both preabrasion freezing and postabrasion refreezing could produce damage additive to that of mechanical planing. skin surface and intradermal temperature variations during refrigeration were recorded. the possible implications of these findings as th ...19854008684
peripheral plasma prolactin concentrations during oestrous cycles in different types of primitive gilt.plasma prolactin concentrations were determined by radioimmunoassay during oestrous cycles and around the time of oestrus in different types of primitive gilts: vietnamese, zlotnicka and wild-boar x domestic pig hybrids. the animals were bled without stress from an indwelling arterial catheter. the following results were obtained: (1) in all gilts the main prolactin peak was observed at day 15 or 16 of the oestrous cycle; (2) vietnamese and hybrid gilts showed a second smaller prolactin surge af ...19854038515
assignment of the porcine major histocompatibility complex to chromosome 7 by in situ hybridization.the major histocompatibility complex (sla) of the domestic pig (sus scrofa) was regionally mapped to 7p12----q12 by in situ hybridization with an sla class i-specific recombinant dna probe. this localization contradicts linkage data suggesting a possible assignment of the sla locus to porcine chromosome 15.19854042688
topical chemotherapy of intradermal walker 256 carcinosarcoma with diaziquone and doxorubicin in the rat.a model for metastatic skin cancer using intradermal injection of walker 256 carcinosarcoma has been developed in the rat. using this model, antitumor activity of topically applied doxorubicin and diaziquone in vanicream, plastibase, and dimethyl sulfoxide (dmso) as vehicles was compared with intraperitoneal injection of the drugs at the same doses beginning 4 days after injection of tumor cells. doxorubicin applied topically at 0.5 mg/day for 4 days in vanicream or plastibase exhibited no antit ...19854053022
effects of different-shaped tissue expanders on transluminal pressure, oxygen tension, histopathologic changes, and skin expansion in pigs.this study, performed on domestic pigs, was designed to show whether the shape and size of a tissue expander influences the amount of surface area increase. when a defect is irregular, a larger custom-fitted implant is more efficient than several smaller expanders. oval implants gained 5 percent more skin using 50 percent less time and almost 20 percent less intraluminal pressure, while u-shaped implants yield 2.2 percent more skin in 10 percent less time with 35 to 50 percent less pressure when ...19854059413
reperfusion before global ischemic arrest improves the salvage of infarcting myocardium.to study the effect of hypothermic global ischemic arrest on an evolving myocardial infarction and of perfusion of the ischemic zone or region at risk before global ischemia, 62 farm pigs underwent 15, 30, or 60 minutes of reversible coronary occlusion. twenty-eight of these animals served as controls: reflow to the region at risk was established by removal of the coronary occluder without the addition of global ischemia. another 26 animals had similar periods of coronary occlusion and then were ...19854062403
a four-year survey of african swine fever in malawi.a serological survey of free-ranging domestic pigs in the central and southern regions of malawi, together with laboratory data on confirmed cases of african swine fever (asf) and data from interviews with pig owners, undertaken over a four-year period from 1981-4, has enabled the asf enzootic area of malawi to be identified. the area covers much of the western part of the central region and includes mchinji district and parts of kasungu, ntchisi, dowa and lilongwe districts. mortality is substa ...19854067292
[effect of sodium selenite on the course of acute experimental myocardial infarct].the effect of sodium selenite on experimental myocardial infarction was investigated in 47 domestic pigs, with a major emphasis on the hemodynamic antiarrhythmic effects of selenium. intravenous sodium selenite administered in a dose of 1-2 mg/kg body weight produced a favorable pharmacologic effect. the hemodynamic action consisted in an increase of heart rate, and the maximum aortic flow rate, cardiac output, minute volume of the heart and coronary flow, as well as a decrease in total peripher ...19854079230
[mathematical formulations of the fetal mass growth in cattle].after a short review of investigations into fetal weight growth of cattle, the first mathematical treatment of values gained by swett and collaborators (1948) and approximated by simple power functions after a proposal from bereskin and touchberry (1967) is recalled. thereafter values for the weight of fetus and uterus with content as summarized by huth (1962) are approximated with growth functions applying nonlinear regressions. the 6 functions taken into consideration range from classical to q ...19854096405
endoscopic treatment of bronchus stump fistulae following pneumonectomy with fibrin sealant in domestic pigs.occlusion of the transected bronchus after pneumonectomy was achieved by transthoracic fibrin sealing in 14 domestic pigs. in 9 additional animals standardized bronchus stump fistulae could also be closed with fibrin sealant which was applied through a flexible bronchoscope. an average of 1 ml of fibrin sealant containing 500 units of thrombin and 3500 units of aprotinin was necessary to achieve bronchial closure and to prevent early dissolution of the sealant. endoscopic closure of a bronchus f ...19852417369
the oxygen affinity of mammalian hemoglobins in the absence of 2,3-diphosphoglycerate in relation to body weight.we studied the oxygenation of mammalian hemoglobins: mouse (mus musculus molossinus), rabbit (oryctolagus cuniculus domesticus), japanese monkey (macaca fuscata), man (homo sapiens), sheep (ovis aries), llama (lama glama), pig (sus scrofa domesticus), cow (bos taurus domesticus) and horse (equus caballus), in the absence of 2,3-diphosphoglycerate (dpg) and compared their oxygen affinity in relation to the body weight. the negative correlation between body weight and the oxygen affinity of the wh ...19852866879
ontogeny of neuropeptidergic systems: luteinizing hormone releasing hormone (lhrh); somatostatin (srif) and neurophysin (nf) in the hypothalamus of the domestic pig by immunocytochemistry.the ontogenic development of some hypothalamic neuropeptides: luteinizing hormone releasing hormone (lhrh); somatostatin (srif) and neurophysin (nf) and their localization in the hypothalamus of fetuses in different stages of the fetal life were studied by immunoperoxidase method. it was found that differentiation of the neurons which produce the examined hormones begins in the midstage of pregnancy. lhrh is stored in the nerve terminals of the median eminence (me) and organum vasculosum of the ...19852867938
detecting changes of arterial and venous blood flow in flaps.island skin flaps based on the latissimus dorsi muscle were raised in domestic pigs. simultaneous recordings of laser doppler flowmetric and laser photometric values were made on the skin in the middle of the flap. occlusion of either the artery or the vein of the pedicle was accompanied by very low laser doppler flow values. in laser photometry the total intensity of backscattered light remained unchanged or was sightly increased during arterial occlusion. in response to venous occlusion, howev ...19852935062
comparison of intraosseous, central, and peripheral routes of sodium bicarbonate administration during cpr in pigs.obtaining venous access continues to be one of the most difficult problems faced by a physician caring for the pediatric patient in cardiac arrest. our study examined the use of the intraosseous route (through the bone) to obtain venous access for sodium bicarbonate administration in a cardiac arrest model. ventricular fibrillation was induced in 23 domestic swine. cardiopulmonary resuscitation was performed for five minutes and sodium bicarbonate (1 meq/kg) was administered through a peripheral ...19852998236
substance k: vascular and cardiac effects in rat and pig.the effects of substance k (sk), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. in pithed rats, sk (10 nmol/kg, iv) produced a triphasic mean blood pressure (map) response: short depressor, short pressor (+11 +/- 1 mmhg), and prolonged depressor phase (-9 +/- 1 mmhg, n = 9-24, p less than 0.001). neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or p ...19853001674
strain-specific 1.7 kilobase repetitive deoxyribonucleic acid sequence family in trichinella spiralis.eco ri digestion of bulk dna from trichinella spiralis p1, an isolate from domestic pig, reveals the presence of families of repetitive sequences. one of the most prominent of these has a monomer size of 1.7 kb, which exists in minimally dispersed direct tandem arrays, with a copy number of about 2800, and represents 2% of the genome. although there is evidence that the eco ri site is missing in some of the family members and that a 1.9 kb variant of the sequence also occurs, the family is highl ...19863027555
protective immunity to ascaris suum: analysis of swine peripheral blood cell subsets using monoclonal antibodies and flow cytometry.outbred domestic swine or sla inbred miniature swine were exposed to ascaris suum either naturally on contaminated lots or by inoculation with uv-irradiated attenuated eggs. both inbred and outbred swine developed virtually complete protection to a challenge of 10 000 eggs after natural exposure, but inbred swine were less resistant than outbred swine after uv-egg exposure. flow cytometric analysis of peripheral blood mononuclear cells from these animals, performed to determine changes in cell s ...19862939618
a preliminary comparison of trypanosoma simiae and t. congolense by isoenzyme electrophoresis.trypanosoma simiae, although similar to t. congolense in morphology and mode of development in the tsetse vector, is regarded as a separate species mainly because it is highly pathogenic to the domestic pig and fails to infect rodents. to establish whether the two species are distinct biochemically, we compared by isoenzyme electrophoresis 2 isolates of t. simiae with 7 stocks of t. congolense, together with one of t. brucei. all isoenzyme patterns of the 6 enzymes examined differed in t. simiae ...19862872783
trypanosoma brucei infection in domestic pigs in a sleeping sickness epidemic area of uganda. short communication. 19862874715
production and evaluation of specific antisera against sera of various vertebrate species for identification of bloodmeals of glossina morsitans centralis.specific antisera against sera of 46 species of vertebrates were prepared. the antisera to 21 bovidae species were raised in goats except the antiserum to goat serum which was raised in sheep. the antisera to 3 suidae species were produced either in domestic pigs or warthogs, while antisera to most of the other vertebrate species were raised in rabbits. the antisera were used in an enzyme-linked immunosorbent assay (elisa) to identify the source of bloodmeals ingested by teneral and non-teneral ...19862882665
similar epidermal changes in hyperkeratotic scabies of humans and pigs.we compared some morphological and biochemical aspects of the epidermal changes occurring in hyperkeratotic scabies in humans and domestic pigs. clinically and histologically, pig skin alterations look very similar to those observed in humans, i.e., brittle hyperkeratosis with parakeratotic crusting and thickening of the epidermis. parakeratosis seems to correspond to previous passage of scabies mites through the incompletely differentiated layers of the epidermis. indeed, by serial sectioning w ...19862425653
conservation of diagnostic antigen epitopes among biologically diverse isolates of trichinella spiralis.crude and immunoaffinity-purified excretory-secretory antigens derived from a domestic pig isolate of trichinella spiralis were used in an enzyme-linked immunosorbent assay to test serum from mice infected with 25 different pig and wild animal isolates of t. spiralis sspp. all of the sera were found positive by elisa using either of the antigen preparations, indicating all isolates shared certain antigen epitopes. excretory-secretory antigens were prepared from 3 distinct isolates of t. spiralis ...19862434638
[effect of iloprost on aggregation behavior in kidney conditioning and changes in iloprost concentration in kidney preservation].the conditioning of the donor by 1.0 microgram/kg x min iloprost over 15 minutes leads to a considerable inhibition of the aggregation of thrombocytes in the domestic pig. 160% more adp had to be added than before the application of iloprost. when 0.5 microgram/ml iloprost are added to the perfusion fluid and to the reperfusion fluid 0.22 microgram/ml and 0.27 microgram/ml, respectively, are to be proved in the venous efflux. whether or not the difference is absorbed or metabolized must remain o ...19862437731
comparison of experimental hypercholesterolemia and atherosclerosis in göttingen mini-pigs and swedish domestic swine.mini-pigs of the göttingen strain and domestic swine of the swedish landrace were compared with respect to their susceptibility to alimentary hypercholesterolemia and experimental atherosclerosis. hypercholesterolemia was produced in both strains by adding 11.2% egg yolk and 0.5% cholesterol to the diet. the plasma cholesterol rose significantly faster and reached a higher level in the mini-pigs than in the domestic swine. in both strains most of the elevated plasma cholesterol was found in the ...19863964345
assignment of the major histocompatibility complex to the p1.4----q1.2 region of chromosome 7 in the pig (sus scrofa domestica l.) by in situ hybridization.the pig major histocompatibility complex (sla) was mapped by in situ hybridization. the probe used was a human cdna containing most of the coding sequence for hla-b7. the sla complex was localized to the region p1.4----q1.2 on chromosome 7.19863082605
[epidemiologic survey of the cysticercosis endemic on réunion island].the high incidence of cysticercosis was underestimated in reunion island before computed tomography (january, 1984). in 1974, soulayrolles et boyer-vidal found that cysticercosis was responsible for 0.5 p. 100 of the cases of epilepsy. in hospitalized people, routine cranial and muscles radiographies detected: 1/among 242 epileptics: 183 men: 36 positive (19.67 p. 100); 59 women: 9 positive (15.25 p. 100), 2/among 166 non epileptic-related neurological disorders: 106 men, 6 positive (5.66 p. 100 ...19863797934
storage of pathogenic leptospires in liquid nitrogen.the virulence and viability of various serovars of leptospira interrogans were successfully preserved by storage in liquid nitrogen. dimethyl sulphoxide at a final concentration of 2.5% (v/v) was added as cryoprotectant to a culture of leptospires grown in ellinghausen-mccullough-johnson-harris medium. ampoules were cooled at a controlled rate of 1 degree-3 degrees c/min to -70 degrees c, then transferred to the liquid phase of a liquid nitrogen storage unit. glycerol was discounted as a cryopro ...19863804861
electrophoretic polymorphism of erythrocyte leucine aminopeptidase in the wild boar, sus scrofa.an erythrocyte leucine aminopeptidase (rbc lap) electrophoretic polymorphism was detected in italian wild boars, sus scrofa. such a polymorphism has not previously been reported in the domestic pig. it is suggested that this locus could be a marker for genetic differences between the domestic and the wild forms of sus scrofa.19863826759
morphological characteristics of the gyrus dentatus in some animal species and in man.comparative anatomical investigations have been carried out on the gyrus dentatus of rat, fox, cattle, domestic pig, monkey (cercopithecus sabeus) and man. after removal of the brain stem and scaling off the brain substance from the medial aspect towards the lateral aspect, the gyrus dentatus was preserved and its relation with regard to the hippocampus, the fimbria hippocampi and the gyrus parahippocampalis was studied. a rat's gyrus dentatus occupies a rather wide zone on the medial aspect of ...19863717598
porcine coccidia in papua new guinea.faecal samples from 232 domestic pigs raised on concrete, 98 free-ranging village pigs, and five wild boar showed 46.6 (108/232), 54 (53/98) and 80% (4/5) prevalence of coccidian oocysts, respectively. eight species of eimeria, and isospora suis, were recovered. in their descending order of predominance in the pigs raised on concrete, the species of coccidia were e. debliecki (26.7%), e. scabra (22.4%), e. neodebliecki (19.8%), e. porci (15.5%), e. suis (11.6%), e. polita (8.6%), e. perminuta (7 ...19863727342
chromosomal localization of leukocyte interferon gene in the pig (sus scrofa domestica l.) by in situ hybridization.using as a probe pig genomic dna, including the complete interferon alpha gene, we have mapped the leukocyte interferon gene on pig chromosome 1 by in situ hybridization. a total of 196 silver grains were noted on the 106 metaphases scored: 31% of the grains were observed on chromosome 1, and 67% of these were localized in the region 1q2.2----q2.7.19863731881
[individual variability and inheritance of the number and size of the nucleolar organizer regions in chromosomes of domestic swine].individual variability of the number and size of silver-staining nucleolar organiser regions (nor) was studied in 76 pigs of semirechenskaya, big white and duroc breeds. the variability of the nor number is exclusively caused by the presence of the 8nor- allele (the chromosomes of the 8th homologous pair lacking the silver-staining nor). concentration of the 8nor- allele is about 0.7 in the average for all three breeds. all 7 offsprings from the homozygous parents male 8nor- /8nor- and female 8n ...19863732795
polygraphic analysis of the sleep-wake states and the rem sleep periodicity in domesticated pigs (sus scrofa).electrocorticography and concurrent electromyography were used during a total of nineteen 24 hr periods in three juvenile pigs in order to establish the quantitative duration of the sleep-wake states and the rem sleep cycles. wakefulness (w), drowsiness (dr), slow-wave sleep (sws) and paradoxical sleep (rem) occupied respectively 46.5%, 15.9%, 26.7% and 10.9% of the 24 hr period. mean duration of episodes was 4.1 min for dr, 6.2 min for sws and 3.3 min for rem. sleep cycles (sc) duration was 13. ...19863737741
[unsaturated fatty acids in the lipids of the spermatozoa of ovis amon aries l. and sus scrofa domestica l].spectrophotometric investigations were carried out with five unsaturated fatty acids found in the composition of spermatozoid lipids of animals belonging to four breeds of ovis amon aries l. parallel comparative analysis were made of the fatty acids in the lipids extracted from spermatozoa of landrace swine of the sus scrofa domestica l. species. differences were established as to the percent content of fatty acids, having low points of freezing. it is believed that the criterion of cold resista ...19863765375
the analgesic effect of buprenorphine, etorphine and pethidine in the pig: a randomized double blind cross-over study.in order to find a suitable analgesic for the treatment of postoperative pain in pigs the analgesic effect of buprenorphine, etorphine and pethidine has been compared in 8 domestic pigs. for assessment of the analgesic action on thermal (hot plate) and two mechanical (cannulation of ear vein, needle prick) noxious stimuli have been employed. in a pilot experiment on 2 pigs in which methadone was included the maximal effective doses were estimated for each drug. methadone was found unsuitable bec ...19863766147
povidone-iodine in polyethylene oxide hydrogel dressing. effect on multiplication of staphylococcus aureus in partial-thickness wounds.we studied the ability of a polyethylene oxide hydrogel dressing (vigilon) containing povidone-iodine to prevent staphylococcus aureus proliferation in partial-thickness wounds. we previously reported that a single application of povidone-iodine on wounds challenged with 2 x 10(6) s aureus was not effective in reducing the number of s aureus after 24 hours. it was therefore hypothesized that povidone-iodine might be effective if it was available continuously and applied to wounds containing a sm ...19863767400
effect of a reduction in blood viscosity on maximal myocardial oxygen delivery distal to a moderate coronary stenosis.this study tested the hypothesis that a reduction in blood viscosity by means of isovolumetric hemodilution will permit an increase in maximal oxygen delivery to myocardium distal to a moderate coronary arterial stenosis. it is known that blood viscosity is a determinant of resistance to blood flow at both the stenotic and the arteriolar levels. accordingly, a reduction in blood viscosity could exert a favorable influence on maximal myocardial oxygen delivery in the setting of stenosis, provided ...19863769166
the pig as a model for myocardial ischemia and exercise.the pig has been well characterized as an appropriate model for the study of coronary physiology, the coronary collateral circulation and exercise physiology. we compared both yucatan miniature swine and young farm pigs in experiments involving myocardial ischemia, infarction and exercise. the yucatan pig was vigorous, docile and proved to be an appropriate model of coronary physiology and exercise in man. the exercise capacity of the yucatan pig was greater than that of the similar weight hamps ...19863773444
long-acting intramuscular anesthetic regimen for swine.a two-stage, long-acting, injectable anesthetic regimen which provided pain-free restraint for swine was developed using nine mixed-breed domestic pigs. each animal was administered a first-stage drug combination consisting of meperidine hydrochloride and azaperone in the caudal thigh muscles, followed after 20 minutes by a second-stage group of injections consisting of ketamine hydrochloride combined with morphine sulfate in the same muscles of the opposite leg. a mean surgical anesthetic time ...19863773452
serum biochemistry of healthy yucatan miniature pigs.sera collected from 24 (12 boars and 12 gilts) healthy, fasted 28-43 week-old yucatan miniature pigs were analyzed for 21 clinical chemistry parameters. the mean, standard deviation, median, and observed range for each parameter are presented as reference values for the normal blood chemistry for this breed. comparison with published values reveals that the yucatan miniature pig has a blood chemistry profile comparable to that of domestic pigs and other breeds of miniature swine.19863773456
role of adenosine in mediating myocardial blood flow response to isoproterenol: observations in closed chest, sedated, domestic swine.to test the hypothesis that adenosine is required to mediate the sustained increase in myocardial flow evoked by isoproterenol haemodynamic indices, myocardial blood flow (microspheres), and regional myocardial oxygen consumption were measured in eight closed chest, sedated pigs at control, after isoproterenol (6.9(2.8) ng x kg-1 x min-1 (mean (sd)) infused into the left anterior descending coronary artery, repeat control, and after a simultaneous infusion of the same dose of isoproterenol and a ...19863779747
pig beta-lactoglobulin i (sus scrofa domestica, artiodactyla). the primary structure of the major component.beta-lactoglobulins from pooled milk (sus scrofa domestica) are isolated and characterized. the complete primary structure of the major beta-lactoglobulin component i is presented. the amino-acid sequence was elucidated by automated edman degradation of tryptic peptides and cyanogen bromide cleavage products in a liquid phase sequencer. the tryptic and cyanogen bromide peptides were separated by reverse-phase (rp-2) or size exclusion (tsk 2000 sw) high performance liquid chromatography. pig beta ...19863790256
[periodontal diseases in domestic swine]. 19863467471
gross anatomy of the mandibular joint and masticatory muscles in the domestic pig (sus scrofa).the mandibular joint (mj) and masticatory muscles in 15 domestic pigs, aged 1 year, were investigated during and after dissection. the joint consisted of a fossa, disc and condyle surrounded by a ligamentous capsule. the fossa was almost flat, slightly convex antero-posteriorly and concave medio-laterally; the disc was biconcave and the condyle oval. the long axis of the condyles formed an anteriorly orientated angle to the frontal plane. the masticatory muscles were similar to human ones except ...19863479064
[treatment of sarcoptic mange in wild and domestic swine with ivermectin (ivomec)]. 19863536415
prostacyclin and thromboxane a2 in septic shock: species differences.prostacyclin and thromboxane a2 have been implicated as mediators of septic shock. correlations between the human prostanoid response to sepsis and experimental paradigms are poorly understood. the purpose of this study was to compare changes in plasma levels of prostaglandin 6-keto-f1 alpha (pgi) and thromboxane b2 (txb) during septic shock in sprague-dawley rats, domestic pigs, mongrel dogs, and man. severe sepsis followed by septic shock (systolic bp less than 90 mmhg) was induced in rats by ...19863539388
measurement of plasma adenosine concentration: methodological and physiological considerations.this study tested the hypothesis that measurements of plasma adenosine concentration made on samples of blood obtained in dipyridamole and ehna (i.e., "stopping solution") may be falsely elevated as a result of ongoing in vitro production and accumulation of adenosine during sample processing. studies were performed with samples of anticoagulated blood obtained from anesthesized domestic swine. adenosine concentration of ultra filtrated plasma was determined by high-pressure liquid chromatograph ...19873554257
"atraumatic" transjugular needle for portal vein puncture in swine.a new coaxial needle-catheter system was designed for transjugular portal vein puncture in young domestic swine. it was tested in 32 animals and successfully entered the portal circulation via a hepatic vein or intrahepatic portion of the inferior vena cava. no complications were encountered.19873562845
evidence for aggression-modulating pheromones in prepuberal pigs.a series of behavioral bioassays were conducted to determine the aggression-influencing properties of urine and other fluids. subjects were prepuberal castrated male and female domestic pigs from commercial stocks. in the behavior assay, pigs were painted with a test fluid and grouped for a videotaped 90 min observation period. experiment 1 validated use of videotape recording by showing that duration of aggressive behavior registered live was correlated with that obtained from video records (r ...19873566690
biochemical events during stapling of the proximal tibial epiphyseal plate in pigs.epiphyseal stapling is considered a safe, effective method of correcting angular deformities of the knee in growing children. a study of the underlying biochemical events would contribute to a better understanding of the control of longitudinal growth rate in epiphyseal growth plates and of the molecular pathology of exaggerated physiologic bowleg or knock-knee deformities. blount stainless staples were applied to the medial side of the proximal tibia epiphyseal growth plate of domestic pigs. th ...19873568490
the high resolution r-banded karyotype of the domestic pig, sus scrofa domestica l.a representative haploid r-banded karyotype of the domestic pig, and a diagrammatic representation of the banding patterns at the 550 band level are presented.19873568755
trichinella spiralis in an agricultural ecosystem. ii. evidence for natural transmission of trichinella spiralis spiralis from domestic swine to wildlife.epidemiological investigations of an outbreak of trichinellosis were carried out in a domestic swine herd and it was established that the parasite also occurred in rats, and in skunks, opossums, and raccoons. because considerable uncertainty exists regarding the role of sylvatic trichinellosis as a reservoir for the synanthropic cycle, studies were conducted to determine the genetic nature of the various isolates from this ecosystem. pig infectivity trials, isoenzyme analyses, and repetitive dna ...19873572642
a comparison of three geographical isolates of trichinella spiralis from the mid-atlantic united states.three isolates of trichinella spiralis (black bear: 41o50'n, 79o00'w, 1982; grey fox: 41o00'n, 76o00'w, 1982; domestic pig: 39o80'n, 75o30'w, 1983) from the mid-atlantic united states were characterized in crl: cobs cfw (sw) mice during 10 successive 40-day generations. over 10 generations, the isolates differed as follows: worm position of the ursine isolate was significantly more posteriad compared to the porcine isolate; sex ratio of the vulpine isolate was significantly lower compared to the ...19873572653
articular cartilage blood vessels in swine osteochondrosis.perfusion studies in swine with early lesions of osteochondrosis demonstrated that lamellar areas of chondrocyte necrosis within reserve zones of growth areas occurred only in regions of nonperfused articular cartilage. articular cartilage with a similar anatomical location was perfused in some animals. occasionally, nonperfused articular cartilage showed vascular alterations within cartilage canals without evidence of significant perivascular or lamellar necrosis. by light microscopy, some vess ...19873576906
a reciprocal translocation (7q-;12q+) in the domestic pig. 19873583780
biliary and urinary excretion of peptide leukotrienes in the domestic pig.the metabolism of leukotriene (lt)c4 and its major routes of elimination in vivo have been studied in four anesthetized domestic pigs administered intravenous [3h]-ltc4 (0.5 microci/kg). the kinetic profile of ltc4 in the blood was followed for 60 min after administration while the biliary and urinary excretion of ltc4 and its metabolites were determined over a 120 min interval. the total recovery of radioactivity in bile and urine was 45% +/- 1 (n = 3) and 18% (n = 2) respectively. examination ...19873588975
in vitro normalization of cholesteryl ester content and particle size of fish eye disease high density lipoproteins.isolated high density lipoprotein (hdl) from the two living fish eye disease patients have been incubated in vitro with autologous lipoprotein depleted plasma or with lipoprotein depleted plasma from domestic pig (sus domesticus), with and without the presence of lcat inhibitor for 24 hours at 0 and 37 degrees c. the lecithin:cholesterol acyltransferase (lcat) activity in lipoprotein depleted pig plasma increased the abnormally low cholesteryl ester content of the fish eye disease hdl particles ...19873591466
influence of steroids on hemorrhagic and traumatic shock.a hemorrhagic-traumatic shock model in 20 domestic pigs (sus scrofa) was used to evaluate the pharmacologic effect of methylprednisolone in preventing disseminated intravascular coagulation (dic). pairs of animals were anesthetized with thiopental and both femoral arteries cannulated. four ml/kg-1 of blood were withdrawn, frozen, thawed, and returned to the animal. one femoral artery cannula was connected to a blood pressure monitor for arterial systolic, diastolic, and mean pressures along with ...19873599114
[structure of the efferent ductules of the domestic pig (sus scrofa domestica)].the ductuli efferentes of the pig have 2 distinct and continuous segments: the proximal or intratesticular segment that is formed in sequence to the labyrinthic portion of the rete testis, on the cranial extremity of the testis, and the distal or epididymal segment that forms the cani vasculosi or lobuli epididymidis. the testicular ductuli are more thicker and the epididymal ductuli are more thin, long and flexuous. the last segment is very coiled and forms a bulboid structure that is placed in ...19873605639
effects of pentoxifylline on experimental skin flap survival.we studied the effects of pentoxifylline on experimental skin flap survival in the domestic pig. random skin flaps were designed using a length-width ratio of 5:1. the pigs were then given pentoxifylline (25 mg/kg/d) or placebo for seven days. fluorescein sodium was used to help determine surviving skin flap length seven days postoperatively. results showed no significant difference in mean surviving skin flap length between the study and control groups. we question the value of pentoxifylline i ...19873606845
the r-banded karyotype of the domestic pig (sus scrofa domestica l.). 19873610655
variations in the monoamine oxidase-inhibitory activity ("tribulin?") in pig's urine.sandler and his colleagues (see sandler, 1982) have demonstrated the presence of an endogenous inhibitor of the enzyme monoamine oxidase (mao) and of benzodiazepine receptor binding in the urine and blood plasma of man and rat. the concentrations of this material increased under stress conditions and it has been named "tribulin". in the present experiments mao-inhibitory activity was found in extracts of urine and plasma samples of domestic pigs. evidence was obtained that the inhibitory activit ...19873625194
failure of foreign serum injections to induce immune vasculitis and to accelerate spontaneous or cholesterol-induced atherosclerosis in swine.experiments were conducted with domestic swine in an attempt to accelerate and/or modify spontaneous or cholesterol-induced atherosclerosis through immune complex-produced changes in the arterial wall. for the purpose of comparison, another experiment was carried out with rabbits. swine differed completely from rabbits in that various experimental designs failed to produce immune complex arteritis and fibroproliferative arteriosclerosis. in addition, two foreign serum infusions (human plasma and ...19873632754
[changes in the content of membrane phospholipids of subcellular structures of skeletal muscle in halothane-induced malignant hyperthermia of the domestic pig]. 19873651204
the occurrence of trypanosoma (nannomonas) simiae in the cerebrospinal fluid of domestic pigs. 19873658977
gastrointestinal absorption of americium-241 by orally exposed swine: comparison of experimental results with predictions of metabolic models.two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9 x 10(8) bq (5.2 mci) of 241am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. all animals were systematically dissected, and the eviscerated carcass ...19873659299
trypanosome infections in glossina spp. inhabiting peridomestic agroecosystems in nsukka area, anambra state, nigeria.trypanosome infections in glossina spp. inhabiting three peridomestic agroecosystems in nsukka area were studied by dissection from april 1984 to july 1985. approximately 0.65% of 4620 g. tachinoides and none of 17 g. palpalis were found with maturing or mature trypanosome infections. of these infections, 20% were due to the trypanosoma brucei group, 40% to the t. congolense group, and 40% to a mixture of the t. brucei and t. congolense groups. trypanosome infection rates did not differ signific ...19873662674
role of adenosine in mediating the coronary vasodilative response to acute hypoxia.to test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery. cardiac lymph adenosine deaminas ...19873664545
study of cathepsin a, b and d activities in the skin wound edges. its application to the differential diagnosis between vital and postmortem wounds.the aims of the authors in this paper has been to check the diagnostic ability of the cathepsin a, b and d concentrations in the skin wound edges to the differential diagnosis between vital and postmortem wounds. we have studied 56 domestic pigs grouped in seven experimental series consisting of 8 animals in each, according to the time (0, 5, 15, 30 min and 1, 3 and 6 h) after the injury. the enzymatic activities were investigated following the methods by bowen and davison biochem. j., 131 (1973 ...19873679037
cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig.in previous studies we have shown that platelet-activating factor (paf) is a potent vasoactive substance with deleterious effects on coronary blood flow (cbf) and myocardial performance. the present study further investigates the effects of paf during its sustained intracoronary infusion in the blood-perfused domestic pig (n = 16). paf infusion (1-9 nmol/min) produced triphasic changes in cbf (n = 7): an initial brief phase of coronary dilation (14 +/- 2% above baseline), followed by severe redu ...19873685397
hepatic vs. gastrointestinal presystemic extraction of oral midazolam and flurazepam.an experimental model was developed to elucidate the site of presystemic extraction of drugs with incomplete bioavailability due to high extraction after p.o. dosage. domestic pigs received single i.v. or p.o. doses of midazolam (1 mg/kg) or flurazepam (2 mg/kg), two benzodiazepine derivatives with high presystemic extraction after p.o. dosage. multiple blood samples were simultaneously drawn from the portal vein and from a systemic vein during 8 hr after dosage. after i.v. administration, both ...19873694534
absence of a nocturnal rise in either norepinephrine, n-acetyltransferase, hydroxyindole-o-methyltransferase or melatonin in the pineal gland of the domestic pig kept under natural environment photoperiods.castrated male and intact female pigs were kept under natural photoperiodic and temperature conditions and were killed over a 24 h period in either may (under long days) or in december (under short days). neither the pineal norepinephrine (ne) concentration nor the melatonin content rose at night; likewise, neither the activities of n-acetyltransferase (nat) nor hydroxyindole-o-methyltransferase (hiomt) increased during darkness. in may pineal melatonin content actually decreased (p less than 0. ...19873696466
experimental intrahepatic portacaval anastomosis: use of expandable gianturco stents.original gianturco expandable stents and their modifications were used to create an experimental intrahepatic portacaval anastomosis (eipca) in 30 young domestic swine without portal hypertension. the study focused on the design of a suitable stent, the technique of its application, and the evaluation of short-term patency of the eipca. a stent with a 2.5-cm-long body and wire skirts on both ends was most suitable for eipca creation. well-positioned stents shunted most of the portal blood in the ...19873797662
a computer model of hemorrhagic shock in domestic swine.we used a modified version of the computer model of the circulation developed by c.v. greenway (pharmacol rev 33:213-251, 1982) to study the volume-pressure relationship of the systemic venous circulation during and immediately after massive blood loss. our theoretical predictions were based on experimental measurements performed in conscious, chronically instrumented swine subjected to massive and rapid loss of a predetermined amount of blood. these animals were subjected to an exponential remo ...19873829330
tendons: high-field-strength, surface coil mr imaging.high-resolution magnetic resonance (mr) images of the tendons of the hands, wrists, feet, and ankles of six healthy volunteers and six cadavers were obtained using receive-only surface coils and reduced-field-of-view imaging. normal anatomy was identified and compared with gross anatomic sections of the six cadavers. experimentally produced tears of the calcaneal (achilles) tendon in domestic swine were identified on mr images. the hands and feet of 11 patients were examined, and a variety of pa ...19873809487
intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs.intravenous access for the administration of antiepileptic drugs can be both time-consuming and difficult in an actively seizing infant. we conducted a study to examine the intraosseous route as an alternate means of vascular access for the administration of diazepam in a pentylenetetrazol-seizure model in pigs. epileptogenic activity was induced with pentylenetetrazol 100 mg/kg in 15 domestic swine that had undergone craniotomies for electrocortical recording. diazepam (0.1 mg/kg) was administe ...19873800088
intratubular germ cell tumours of pig testicles.in the course for the histopathological examination of testicles of 30 castrated boars the authors have observed in 4 animals the intratubular growth of atypical germ cells. on the basis of the histological picture this change is equivalent to the human infertile testicles, observed as carcinoma in situ, resp. intratubular germ cell tumour. the described phenomenon occurred in atrophic testicles in 3 of the 4 old animals. the described change in the domestic pig, not known so far, raises the pos ...19873425959
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