Publications

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the effects of brainstem lesions on vocalization in the squirrel monkey.the present study is an attempt to find out the brain areas involved in the motor coordination of species-specific vocalization. for this purpose, high-frequency coagulations were placed in a systematic manner throughout the brainstem and posterior diencephalon in altogether 43 squirrel monkeys (saimiri sciureus). the effect of these lesions on different call types elicited by electrical brain stimulation was studied spectrographically. it was found that bilateral destruction of the ventrolatera ...19854075112
functional organization of the medial geniculate body's subdivisions of the awake squirrel monkey.the response properties of 138 cells in the medial geniculate body (mgb), of the awake squirrel monkey (saimiri sciureus), to 7 species-specific vocalizations were studied. cells were divided into 4 subgroups: 26 in the ventral, 24 in the medial and 46 in the lateral subdivision. forty-two cells located on the borders between the subdivisions represent the fourth group. no significant differences were found between the subdivisions with respect to their selectivity, nor did cells in any subdivis ...19854075184
studies on a newly isolated strain of plasmodium brasilianum in aotus and saimiri monkeys and different anophelines.a strain of plasmodium brasilianum was isolated from an aotus vociferans monkey from peru. the parasite readily infected aotus monkeys from bolivia and columbia and saimiri sciureus monkeys from peru and bolivia. highest level mosquito infections were obtained by feeding on the saimiri monkeys. the most susceptible mosquito was anopheles freeborni, followed by anopheles dirus, anopheles stephensi, anopheles gambiae, anopheles culicifacies, anopheles maculatus and anopheles albimanus. anopheles q ...19854093810
social status as determinant of alcohol effects on aggressive behavior in squirrel monkeys (saimiri sciureus).we investigated the behavioral effects of alcohol, especially those on aggression, on members of established groups of squirrel monkeys. a continuous measurement of monkey behavior in groups revealed consistent differences between dominant and subordinate animals. dominant monkeys aggressed more frequently than subordinate monkeys, and spent less time in stationary postures. alcohol produced dose-related biphasic changes in the number of threats, grasps, and displacements exhibited by dominant b ...19852861617
the distribution of somatostatin-like immunoreactivity in the monkey hippocampal formation.the distribution of somatostatin-like immunoreactivity was studied in the hippocampal formation of the old world (macaca fascicularis) and new world (saimiri sciureus) monkeys. series of coronal sections were processed by the unlabeled second antiserum method using primary antisera which recognize somatostatin-28 (s309) or somatostatin-28(1-12) (s320). neuronal cell bodies were more readily stained with antiserum s309 and were observed throughout the hippocampal formation. the most prominent acc ...19852865277
a region of the herpesvirus saimiri genome required for oncogenicity.herpesvirus saimiri naturally infects squirrel monkeys (saimiri sciureus) without producing signs of disease; infection of other new world primates, however, results in a rapidly progressing, malignant, t-cell lymphoma. results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (aotus trivirgatus); this region is not required for replication of the virus. this is believed to be the first such genomic region identified in a herpesvirus ...19852983431
coxsackievirus b4 infection of sympathetic ganglia in squirrel monkeys.lumbar sympathetic ganglionitis was found by light microscopy in 2 of 17 (12%) squirrel monkeys (saimiri sciureus) experimentally infected with coxsackievirus b4. this finding shows that viruses can cause ganglionitis which, in turn, must cause autonomic nervous system dysfunction. such viral ganglionitis may explain some diseases, including cardiovascular ones, of poorly understood or unknown etiology which present with manifestations of dysfunction of the sympathetic nervous system.19852992318
detection and cultivation of intestinal trichomonads of squirrel monkeys (saimiri sciureus).routine examinations of fecal samples from squirrel monkeys suggested that intestinal trichomonads might be common inhabitants of these animals. in pursuit of these observations, microscopic examination of fecal suspensions and cultures have demonstrated a 100% incidence of trichomonads in 30 arbitrarily selected animals from a colony of more than 300 housed in groups of ten. the most prominent species was pentatrichomonas hominis. a not yet fully characterized tritrichomonad was also found on s ...198531986788
maternal recognition of individual infant squirrel monkeys from isolation call playbacks.responses of six squirrel monkey (saimiri sciureus) mothers to playback of a single call type, the "isolation peep," made by their own infants were tested after mothers and infants had been separated for more than a week. the playback tapes were edited from tapes containing mixed vocal material recorded when infants and mothers could see but not touch each other. mothers showed recognition of their own infants compared to other familiar infants by increases in four measures of proximity to the s ...198531986795
luteinizing hormone-releasing hormone in olfactory bulbs of primates.this immunohistochemical study of luteinizing hormone-releasing hormone (lhrh) in the olfactory bulbs in primates was undertaken in order to see whether there was an lhrh innervation in these species similar to that found in rodents. one old world (macaca fascicularis) and two new world (saimiri sciureus and aotus trivirgatus) monkeys were studied. aotus trivirgatus was of particular interest as it is noctural and so presumably more dependent upon olfactory cues. animals were perfused with fixat ...198531986801
sequences and timing of dental eruption in bolivian captive-born squirrel monkeys (saimiri sciureus).squirrel monkeys, colony-born from bolivian parents, were studied to establish the sequences and timing of eruption for deciduous and permanent teeth. infants were born with a naked gingiva, and in only one monkey was di1 present at birth. the eruption of the lower deciduous teeth preceded their upper counterparts with the exception of di2, dc, and dpm2. no significant differences were found between the right and left quadrants of the mandible and maxilla. no significant sexual differences were ...198531986811
species differences in adrenocortical activity of new world primates: response to dexamethasone suppression.the effect of dexamethasone-induced alteration of adrenocortical activity was assessed in two species of new world primates: saimiri sciureus and callicebus moloch. basal and stress levels of corticosteroids were determined following treatment with three doses of dexamethasone (0, 50, or 500 μg/kg). saimiri showed substantially higher basal levels of corticosteroids than did callicebus and a greater incremental corticosteroid response to physical restraint. dexamethasone was found to reduce basa ...198531986807
sexual dimorphism in the postcranial skeleton of new world primates.this study examines sexual dimorphism in 24 dimensions of the postcranial skeleton of four platyrrhine species: callithrix jacchus, saguinus nigricollis, saimiri sciureus, and cebus albifrons. the two callitrichid species show a relatively small amount of variation in the degree of sexual dimorphism among the different dimensions. variation is considerably higher in the two cebid species as reflected by a mosaic pattern of sexual dimorphisms with males being significantly larger than females in ...19854043875
differences between saimiri sciureus and callicebus moloch in physiological responsiveness: implications for behavior.the new world primates callicebus moloch and saimiri sciureus differ markedly in life modes. physiological responsiveness (heart rate, cortisol) of these related taxa was compared in two situations that differed in the presumed degree of stress imposed, exposure to a novel environment and physical restraint. in both situations, saimiri exhibited higher initial levels of heart rate and corticosteroids. in addition, the species differed in their patterns of response to both situations. saimiri mai ...19863802783
effect of separation distance on isolation call structure in squirrel monkeys (saimiri sciureus).isolation calls of captive squirrel monkeys were recorded by separating infants from their natal group members and then permitting vocal contact between the "lost" baby and the group at systematically varied distances. separated infants gave longer calls at greater separation distances from their natal group members, and responding adults and juveniles similarly extended the length of their vocalizations. in the longer variants, a highfrequency element was prolonged, which is considered to be an ...198631979483
case report: esophageal spirura infection in a squirrel monkey (saimiri sciureus).necropsy of an adult, wild-born squirrel monkey (saimiri sciureus) revealed 30 to 40 esophageal nematodes. the anterior end of each nematode was firmly attached to the mucosa, with the remaining portion free in the lumen. histologic changes were limited to the superficial mucosa, where the epithelium adjacent to the nematode was hyperplastic and increased keratin formed a bridge over the body of the parasite. the nematode was identified as belonging to the genus spirura. the number of parasites ...198631979481
comparative studies of social behavior in callicebus and saimiri: behavioral and physiological responses of established pairs to unfamiliar pairs.comparisons were made of the behavioral and physiological responses of heterosexual pairs of two closely related new world primates, callicebus moloch and saimiri sciureus, to confrontations with unfamiliar pairs. subject pairs were exposed to strangers in two situations differing in the presumed degree of arousal they imposed: obligatory (full visual exposure) and facultative (one part of the test cage allowed visual withdrawal). behavioral reactions were evaluated employing frequencies of affi ...198631979464
biochemical and hormonal correlates of dominance and social behavior in all-male groups of squirrel monkeys (saimiri sciureus).this study examined the relationship between dominance rank and several physiological and behavioral measures in stable, captive, all-male squirrel monkey groups. four groups, each containing three males, were observed for 12 weeks during the breeding season. relative dominance ranking among males in each group was based on the direction of agonistic behaviors displayed. for each subject, whole blood serotonin (wbs), plasma testosterone (t), and cortisol (c) were sampled 4 to 6 times over the co ...198631979459
choline acetyltransferase and acetylcholinesterase activities in neocortex and hippocampus of squirrel monkey (saimiri sciureus).the activities of choline acetyltransferase (chat) and acetylcholinesterase (ache) were measured in five neocortical regions and in the hippocampal formation of one hemisphere in eight 30-day-old squirrel monkeys. enzyme levels in the hippocampal formation (hippocampus, dentate gyrus, and subiculum) were higher than in any neocortical region. within neocortex, chat activity was highest in superior temporal and precentral regions, intermediate in prefrontal and postcentral regions, and lowest in ...198631979455
trypanosoma cruzi and trypanosoma rangeli in saimiri sciureus from bolivia and saguinus mistax from brazil.examination of blood films for trypanosomes in primates housed at the tulane university delta regional primate research center showed that 47% (32/68) of the bolivian saimiri sciureus and 51% (68/135) of brazilian saguinus mistax harbored one or more types: trypanosoma (schizotrypanum) cruzi in 6% to 7% and trypanosoma (herpetosoma) spp. or trypanosoma (megatrypanum) spp. in 39% and 45%, respectively. trypanosomes were isolated from a sample of the infected monkeys and morphobiological studies w ...19863082228
involvement of monoamine oxidase enzymes in the action of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, a selective neurotoxin, in the squirrel monkey: binding and biochemical studies.1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (mptp) is a new neurotoxin that causes degeneration of the dopaminergic nigrostriatal neurons and induces a parkinson-like state in several species, including humans and monkeys. the present study was designed to better characterize the properties of [3h]mptp binding sites and to evaluate the interaction of mptp with the oxidation of dopamine by monoamine oxidase (mao) in an animal species (saimiri sciureus) shown to be lesioned by mptp. our data conf ...19863089539
afferent connections of the substantia innominata/basal nucleus of meynert in carnivores and primates.afferent connections to the substantia innominata/nucleus basalis complex of monkeys and cats were traced by using the method of retrograde transport of horseradish peroxidase (hrp). altogether ten injections of hrp were performed in four monkeys (saimiri sciureus, callithrix jacchus, galago senegalensis) and in four cats, with either vertical or oblique needle approaches. the entire brains excluding the olfactory bulbs and the cerebellum were then screened for labeled neurons. in both monkey an ...19863093564
postnatal changes of igg and igm levels in squirrel monkeys (saimiri sciureus).serum igg and igm levels were measured in domestically bred squirrel monkeys (saimiri sciureus) ranging in age from 0 days to 42 months, as well as in adult squirrel monkeys from the wild estimated to be 60 months or older. the results indicated that the transplacental transfer of igg occurs in the squirrel monkey but the transferability is lower in the squirrel monkey than in the cynomolgus monkey. immune response in the squirrel monkey occurs just after birth, as shown by igm production.19863100807
neuropeptide y-immunoreactive neurons in the striatum of cat and monkey: morphological characteristics, intrinsic organization and co-localization with somatostatin.a detailed study of the distribution of neuropeptide y (npy) in the striatum of squirrel monkey (saimiri sciureus) and cat was undertaken by means of indirect immunofluorescence and peroxidase-antiperoxidase (pap) methods. in monkey, the npy-immunoreactivity is homogeneously distributed along the entire extent of the caudate nucleus (cd) and putamen (put), while in cat marked heterogeneities are noted. in the cd of cat, the npy-immunoreactive fibers and cell bodies are concentrated in numerous p ...19862871900
an immunohistochemical characterization of somatostatin-28 and somatostatin-281-12 in monkey prefrontal cortex.the distribution of the prosomatostatin-derived peptides (psdp) somatostatin-28 (ss-28) and somatostatin-281-12 (ss-281-12) was characterized immunohistochemically in the prefrontal cortical regions of both old world cynomolgus monkeys (macaca fascicularis) and new world squirrel monkeys (saimiri sciureus). comparison of staining with antisera specific for each peptide revealed that these antigens were segregated within immunoreactive neurons such that ss-28 was largely confined to the perinucle ...19862873154
a comparative study on the elicitability of vocalization by electrical brain stimulation, glutamate, aspartate and quisqualate in the squirrel monkey.in 6 squirrel monkeys (saimiri sciureus), 71 brain sites yielding vocalization when electrically stimulated were tested for their capability to produce vocalization when injected with l-glutamate (glu), n-methyl-d-aspartate (nmda) and quisqualate. out of the 71 sites, only 3 reacted positively to glu, 4 to quisqualate and 7 to nmda. two of the quisqualate-positive sites reacted also to nmda and one to glu. the positive sites were located at the border between the substantia innominata and globus ...19862873531
study of some parameters affecting the in vitro cultivation of plasmodium falciparum within saïmiri sciureus red blood cells.the in vitro growth and multiplication of the erythrocytic stages of plasmodium falciparum within saïmiri sciureus (squirrel monkey) red blood cells have been studied. various parameters, such as the origin of the red blood cells and serum supplement, nature of the buffer, influence of the final ph of the medium, role of proteose peptone and glucose addition, were investigated. the selection of the best culture conditions led to the obtention of a reproducible in vitro growth of two parasite cyc ...19863295467
symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in an old java monkey [macaca cynomolgus fascicularis (raffles)].the study concerns symptoms and behavioral characteristics induced by mptp in a 20-year-old macaca cynomolgus fascicularis, their evolution over 7 months, and the animal's response to 1-dopa treatment. the symptoms which the animal developed include those that have been described earlier in macaca mulatta and saimiri sciureus, i.e., rigidity, action tremor, postural tremor, postural flexion, hypokinesia, and bradykinesia. in addition, however, the animal developed a 3.8 hz resting tremor which i ...19863488798
[elisa test in sero-epidemiologic studies of human malaria. evaluation of an antigen prepared from erythrocytes of saimiri sciureus experimentally infected with plasmodium falciparum].a soluble antigen was prepared from squirrel monkeys (saimiri sciureus) infected with blood-passaged plasmodium falciparum, and evaluated in an enzyme-linked immunosorbent assay (elisa) as a potent antigen for malaria diagnostic. the specificity, reproducibility and sensibility of the test showed the suitability of our antigenic preparation in detecting antibodies, igg and igm, in patients with p. falciparum infections. thus, the saimiri monkey represents an interesting alternative to the classi ...19863516425
adaptation of the indochina i/cdc strain of plasmodium falciparum to the squirrel monkey (saimiri sciureus).the indochina i/cdc strain of plasmodium falciparum was linearly passaged in squirrel monkeys (saimiri sciureus) of 3 phenotypes. splenectomized monkeys of guyanan and peruvian type developed high density parasitemias, but considerably lower than the mean peak parasitemia (greater than 10(6)/mm3) in bolivian phenotype squirrel monkeys. spleen-intact bolivian and peruvian squirrel monkeys all developed potentially lethal infections after linear passage of parasites from saimiri and aotus. for the ...19863518503
noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in old and new world monkeys.antisera directed against human dopamine-beta-hydroxylase and against serotonin were used to characterize the noradrenergic (na) and serotoninergic (5-ht) innervation of several cortical and subcortical visual areas in squirrel monkey (saimiri sciureus) and cynomolgus monkey (macaca fascicularis). few species differences were observed for either monoamine. cortical areas 17 and 18, as well as visual areas in the temporal and parietal lobe were found to exhibit regional specialization of both 5-h ...19863950077
the effect of chamber restraint (with or without lower body positive pressure) on hematopoiesis (particularly erythropoiesis) in squirrel monkeys (saimiri sciureus)squirrel monkeys, restrained in lower body positive pressure (lbpp) chambers in attempts to model the space flight-induced hematological consequences of a cephalad fluid shift, showed a decrease in red blood cell mass which was largely independent of actual lbpp. the only lbpp-specific hematological effect was an alteration in red blood cell (rbc) survival. this monkey model represents the second, ground-based animal system in which this phenomenon has been recorded and shown to be unique to a c ...19863959062
urogenital challenge of primate species with mycoplasma genitalium and characteristics of infection induced in chimpanzees.eighteen male and eight female primates, representing five subhuman species, were inoculated urogenitally with mycoplasma genitalium, a microorganism recovered from men with nongonococcal urethritis. male rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) monkeys apparently were resistant. female squirrel monkeys (saimiri sciureus) and female tamarins (saguinus mystax) exhibited low-level, genital-tract infections. male chimpanzees (pan troglodytes) developed an obvious genital-tract i ...19863701116
crossed renal ectopia in a squirrel monkey (saimiri sciureus) and an owl monkey (aotus trivirgatus).a 5-year-old female squirrel monkey, saimiri sciureus, died with a ceco-colonic infarct. an incidental finding was renal ectopia: the left kidney was located between the common iliac arteries posterior to the bifurcation of the aorta and to the right of the body midline. an adult owl monkey, aotus trivirgatus, was killed in renal failure due to end-stage glomerulonephritis. fused kidneys were located on the right side and posterior to the normal position. these are examples of crossed renal ecto ...19863735401
differential connections of caudate nucleus and putamen in the squirrel monkey (saimiri sciureus).the organization of the subcortical connections of caudate nucleus and putamen in the squirrel monkey was studied using horseradish peroxidase conjugated to wheat germ agglutinin as anterograde and retrograde neuronal tracer. the tracer was injected in similar quantities in the putamen on the left side and in the caudate nucleus on the right side in 10 monkeys, and its presence was revealed by means of the tetramethylbenzidine method. the study of anterogradely labeled fibers visualized after su ...19863736862
the organization of hypothalamocerebellar cortical fibers in the squirrel monkey (saimiri sciureus).the organization and distribution of hypothalamocerebellar cortical fibers in squirrel monkey were investigated by using horseradish peroxidase (hrp, wga-hrp) and 3h-leucine as anterograde tracers. following hypothalamic injections, anterogradely labeled fibers coursed bilaterally through the periventricular gray (ipsilateral preponderance) and into the cerebellar white matter. sparse numbers of labeled fibers appeared to descend into the reticular formation and enter the cerebellum via the brac ...19863745521
the inferior olive of saimiri sciureus: olivocerebellar projections to the anterior lobe.olivocerebellar projections to lobules iv and v of the anterior lobe of the squirrel monkey (saimiri sciureus) cerebellum were studied using a wheat germ agglutinin-horseradish peroxidase conjugate (wga-hrp). placements of wga-hrp in the cerebellar cortex, labeled neurons in different subgroups of the contralateral inferior olive depending on the position of the injection site. injections in medial aspects of lobules iv and v labeled cells in subgroups a and b of the caudal medial accessory oliv ...19863754784
testicular and serum testosterone variations in squirrel monkeys during seasonal cyclicity.the seasonal testicular maturation of squirrel monkeys (saimiri sciureus) was used as a model of maturational hormonal regulation of the testis. testicular testosterone and serum testosterone concentrations were determined during the circannual variations of body weight and testicular volume. these data have been correlated with changes in the germinal epithelium. according to individual weight curves and time of the year, the monkeys were divided into five groups: group a1, maximal weight, apri ...19863771368
light and electron microscopic data on field ca1 of the hippocampus of the squirrel monkey, saimiri sciureus.data are presented on the structure and ultrastructure of field ca1 of the hippocampus of saimiri sciureus. in saimiri, as in other higher primates, the pyramidal layer of this field expands into the stratum oriens and shows an extensive neuropil between the perikarya. this neuropil is composed mainly of strong horizontal and oblique side branches of the apical dendrites of the pyramidal cells and a large number of terminal boutons forming predominantly asymmetric contacts on these dendritic pro ...19863794317
comparative studies of squirrel monkeys (saimiri sciureus) and titi monkeys (callicebus moloch): performance on choice tasks in near space.squirrel monkeys (saimiri sciureus) and titi monkeys (callicebus moloch) were studied in tasks involving reaching for food in near space (arm's reach). although performance by monkeys of the two species differed in several ways familiar from previous studies, the species did not differ in the tendency to adopt a habitual position or limb during reaching. the findings contrast with previous work on spatial preferences in these species in tasks involving movement of the whole body. together with t ...19863802784
play vocalizations of squirrel monkeys (saimiri sciureus).vocalizations occurring during play bouts were studied in 2 pairs of young male squirrel monkeys. two main call types, one having four variants, are described. vocalization rate varied with the type of ongoing behavior and with play bout duration, an association considered to be indicative of motivation to play. structural differences also varied with bout duration and longer bouts had longer and more complex calls. in addition to providing direct information about motivation, vocalizations may ...19863804106
leishmania donovani: cellular and humoral immune responses after primary and challenge infections in squirrel monkeys, saimiri sciureus.cellular and humoral immune responses were studied in squirrel monkeys after primary and challenge infection with a khartoum strain (wr 378) of leishmania donovani. each of 7 squirrel monkeys, saimiri sciureus, was inoculated intravenously with 5 x 10(7) amastigotes/kg body weight, and one other monkey (control) was inoculated with uninfected hamster spleen homogenate. five infected monkeys recovered from visceral leishmaniasis and two infected monkeys died. three of the five squirrel monkeys wh ...19862940111
effects of feeding cycles on circadian rhythms in squirrel monkeys.squirrel monkeys (saimiri sciureus) were housed singly in cages equipped with a tree for climbing to measure locomotor activity, and with a movable food cup that could be arrested automatically. the animals were kept in continuous dim illumination (ll), twice interrupted by several weeks of entrainment by a light-dark (ld) 12:12 cycle. apart from three control sections in which the food cups were unlocked continuously (ad libitum feeding), food was accessible for 3 hr per day only, with interfee ...19862979589
interhemispheric connections in the visual cortex of the squirrel monkey (saimiri sciureus).the callosal connections within the posterior parietal and occipital cortices were studied in the squirrel monkey with horseradish peroxidase tracing techniques. the data were evaluated with particular emphasis on the relationship of major callosal connections along the 17-18 border. the overall pattern of callosal connections in the squirrel monkey also was compared with callosal patterns in other new world simians. our results show that the dense band of callosal connections along the 17-18 bo ...19873819037
common input of the cranial motor nuclei involved in phonation in squirrel monkey.our aim was to locate brain regions projecting to all cranial motor nuclei involved in phonation simultaneously, that is, the ambiguus, trigeminal motor, facial, and hypoglossal nuclei. for this purpose, four squirrel monkeys (saimiri sciureus) were injected with horseradish peroxidase, each of the four nuclei in a different animal. those regions retrogradely labeled in all four cases then were injected in another 29 animals with [3h]leucine for anterograde tracing. we found that the only region ...19873792484
polymorphism of the middle wavelength cone in two species of south american monkey: cebus apella and callicebus moloch.the spectral sensitivity of the middle wavelength cone was measured in two species of south american monkey, cebus apella and callicebus moloch, using electroretinogram (erg) flicker photometry. both of these species were found to have a polymorphism of the middle wavelength cone. eight male cebus monkeys each had only a single type of middle wavelength cone having lambda max values of either 550 or 562 nm. eight callicebus monkeys (7 male, 1 female) showed a similar polymorphism of the middle w ...19873424673
organization of efferent projections of the subthalamic nucleus in the squirrel monkey as revealed by retrograde labeling methods.the cellular origin and degree of collateralization of the subthalamostriatal, subthalamonigral and subthalamopallidal projections in the squirrel monkey (saimiri sciureus) were studied using lectin-conjugated horseradish peroxidase (wga-hrp), nuclear yellow (ny) and fast blue (fb) as retrograde tracers. in a first experimental group, wga-hrp was injected in the left putamen and the right caudate nucleus. following these injections numerous retrogradely labeled neurons occurred in the dorsolater ...19873435830
early color deprivation and subsequent color vision in a dichromatic monkey.a squirrel monkey (saimiri sciureus) was reared for the first 4 months of life in a dim, colorless environment. following an additional 10 months of normal visual experience, tests of color vision and spectral sensitivity were run on this animal and a control subject. the results suggest that the adult expression of dichromatic color vision does not depend on color experience during the first 4 months of life.19873447353
inheritance of color vision in a new world monkey (saimiri sciureus).squirrel monkeys (saimiri sciureus) have a striking color-vision polymorphism; each animal has one of six different types of color vision. these arise from individual variation in the presence of three different middle- to long-wavelength cone pigments. the distribution of cone phenotypes was established for a large sample of squirrel monkeys, including several families, through analysis of a retinal gross potential. the results indicate that the inheritance of color vision in the squirrel monke ...19873470811
distribution of gaba-immunoreactive neurons in the basal ganglia of the squirrel monkey (saimiri sciureus).the distribution of gaba-immunoreactive neurons was visualized in the basal ganglia of the squirrel monkey (saimiri sciureus), by using a highly specific antiserum raised against gaba-glutaraldehyde-lysyl-protein conjugate and revealed by the indirect peroxidase-antiperoxidase immunohistochemical method. in the dorsal striatum, gaba-immunoreactive nerve cell bodies were small to medium in size (sectional area ranging from 90 to 125 microns2), but some larger ones (500-600 microns2) were also fou ...19873294929
in vitro and in vivo adaptation of the geneve/sge-1 strain of plasmodium falciparum to growth in a squirrel monkey (saimiri sciureus) model.human erythrocytic culture-adapted parasites of the geneve/sge-1 strain of plasmodium falciparum were successfully adapted to grow in an in vitro culture system containing squirrel monkey erythrocytes and serum. these monkey culture-adapted organisms were then used to produce a patent infection in a splenectomized squirrel monkey. fresh infected blood from this animal was introduced into another splenectomized monkey and was subsequently serially passed through seven intact squirrel monkeys. hig ...19873548448
human and primate malarial sera inhibit fc receptor-mediated phagocytosis.sera obtained from humans in p. falciparum-endemic regions and from p. vivax-infected saimiri sciureus were assayed for their ability to inhibit fc receptor-mediated phagocytosis. some sera of humans exposed to p. falciparum from the gambia, sudan, and thailand inhibited ingestion via the fc receptor by normal human monocytes. in addition, sera from infected monkeys and a high molecular weight fraction of infected monkey serum inhibited ingestion of eigg by normal monkey spleen macrophages. gene ...19873548450
characterization of a 96-kilodalton thermostable polypeptide antigen of plasmodium falciparum related to protective immunity in the squirrel monkey.protective immunity against plasmodium falciparum malaria in the squirrel monkey (saimiri sciureus) is, in part, antibody mediated. we have previously shown that polypeptides of 41, 76, and 96 kilodaltons (kda) are specifically immunoprecipitated with monkey sera which are protective in passive transfer experiments. we report here that three different 96-kda polypeptides, of pi 5.15, 5.25, and 5.35, can be visualized when parasite extracts are analyzed in bidimensional gels. only one of them (of ...19873552999
induction of follicular growth in the squirrel monkey (saimiri sciureus): enhanced recovery of mature ova for fertilization in vitro.in order to improve the rate of recovery of mature ova over those previously reported, we evaluated a new hormonal regimen for induction of follicular growth in the squirrel monkey. this regimen, which consisted of 50 iu pregnant mare's serum (pms) per day for 4 days followed by 50 iu pms and 250 iu human chorionic gonadotropin (hcg) on the 5th day, gave an average yield of 2.3 mature ova per animal from 14 experiments involving 11 animals. ova were recovered through laparotomy or laparoscopy 18 ...19873566354
slow wave changes in amygdala to visual, auditory, and social stimuli following lesions of the inferior temporal cortex in squirrel monkey (saimiri sciureus).radiotelemetry of slow wave activity of the amygdala was recorded under a variety of conditions. power, and the percentage of power in the delta band, increased in response to stimulation. recordings of monkey vocalizations and slides of ethologically relevant, natural objects produced a greater increase in power than did control stimuli. the responses to auditory stimuli increased when these stimuli were presented in an unrestrained, group setting, yet the responses to the vocalizations remaine ...19873566692
differential effects of inferior temporal cortex lesions upon visual and auditory-evoked potentials in the amygdala of the squirrel monkey (saimiri sciureus).visual-evoked potentials (veps) and auditory-evoked potentials (aeps) were elicited from amygdala nuclei and inferior temporal (it) cortex in chaired, alert squirrel monkeys to diffuse flash and click stimuli. veps were recorded from electrodes placed in basalis lateralis amygdalae (bla) and basalis medialis amygdalae (bma) while aeps could also be obtained from additional electrode sites in basalis accessorius medialis (bam), centralis amygdalae (cea), and lateralis amygdalae (la). the amygdala ...19873566694
laboratory studies on mansonella marmosetae in the squirrel monkey, saimiri sciureus. 19873572659
ovaries remain functional in squirrel monkeys (saimiri sciureus) immunized with porcine zona pellucida 55,000 macromolecule.fifty female squirrel monkeys were each immunized with 200 micrograms of a purified preparation of the 55,000 macromolecule (zp3) from porcine zona pellucida. the fertility status of these immunized monkeys, as well as the effect of zp3 antibodies on ovarian function, was monitored. high anti-zp3 titers were achieved (greater than 75% binding levels as determined by radioimmunoassay) and remained high (approximately 67% binding level) for the duration of this study. hormonal evaluations indicate ...19873580465
spontaneous cryptococcosis of a squirrel monkey (saimiri sciureus) in french guyana.an old female squirrel monkey (saimiri sciureus) with a tumor-like growth of the lower jaw died in shock after 2 months of illness. histological studies of different tissue samples demonstrated that the pathological agent was cryptococcus. multiple foci of fungus existed in the thoracic cavity with essentially pulmonary and glandular localizations.19873585974
transmission of plasmodium simium to aotus nancymai, a. vociferans, a. azarae boliviensis, and saimiri sciureus boliviensis monkeys. 19873598812
vasopressin antagonism in the squirrel monkey (saimiri sciureus).vasopressin antagonism and water diuresis (aquaresis) is demonstrated after i.p. or i.v. administration of vasopressin antagonists in a primate species, the squirrel monkey (saimiri sciureus). antagonism of vasopressin-stimulated renal medullary adenylate cyclase activity was evaluated in vitro; the most potent antagonists were those with d-tyrosine (alkyl) substitutions at position 2. aquaresis was evaluated in vivo; the most potent aquaretic agents were again those with d-tyrosine (alkyl) subs ...19873598903
experimental genital trichomoniasis in the squirrel monkey (saimiri sciureus).the squirrel monkey (saimiri sciureus) has been proposed as a model for urogenital trichomoniasis in man, but has not been accepted as such because of the purported presence of naturally occurring vaginal trichomonads in this animal. the study published here shows that these are easily eradicated organisms of intestinal origin, which eliminates the potential confusion created by them. in addition, our experiments have shown that the hormonal status of primates seems to be a determinant in succes ...19873610164
experimental american leishmaniasis in the brazilian squirrel monkey (saimiri sciureus): lesions, hematology, cellular, and humoral immune responses.unulcerated cutaneous lesions appeared and persisted in squirrel monkeys experimentally infected with leishmania braziliensis braziliensis or l. b. panamensis. peripheral blood mononuclear cell (pbmc) numbers increased following infection, and cultured pbmcs from infected monkeys proliferated in response to parasite antigens. the responses of pbmcs to mitogens were not suppressed in infected monkeys. elevated levels of leishmania-specific immunoglobulins m and g were also observed. thus, the squ ...19873612761
oral-facial clefts and associated malformations in the squirrel monkey (saimiri sciureus).of the 414 squirrel monkey pregnancies recorded at this institution since 1977, seven (1.7%) have resulted in offspring with clefts of the lip and/or palate. associated malformations include a ventricular septal defect, renal agenesis, anal atresia, axial skeletal anomalies, and craniorachischisis (anencephaly and spina bifida). three of these infants are the result of consanguineous matings.19873612763
correlative clinical biochemistry and hematological profiles of laboratory-bred bolivian squirrel monkeys (saimiri sciureus).twenty-five clinical and biochemical parameters were determined on 17 normal, male, laboratory-bred bolivian squirrel monkeys (saimiri sciureus). parallel hematologic parameters were conducted. the correlation of biochemical and hematological observations and the distribution characteristics, range, and standard error of the mean were determined. the purpose of the present communication is to establish baseline biochemical values for laboratory-bred squirrel monkeys and to present a correlative ...19873625758
serum oestradiol, progesterone, chorionic gonadotrophin and prolactin concentrations during pregnancy in the bolivian squirrel monkey (saimiri sciureus).concentrations of chorionic gonadotrophin gradually increased during early pregnancy, reached maximum values at mid-gestation, then declined to low levels. oestradiol-17 beta concentrations were relatively low (300-600 pg/ml) during early pregnancy, increased thereafter to high levels (10-35 ng/ml), and then appeared to decline towards term. concentrations of progesterone were constant (100-200 ng/ml) for the first 15 weeks of gestation, suggesting that sequential measurements of progesterone co ...19873656275
morphometry and ultrastructure of the squirrel monkey (saimiri sciureus) vestibular nerve.vestibular nerves of squirrel monkeys (saimiri sciureus) embedded in plastics and epoxies were examined with light microscopy (lm) and transmission electron microscopy (tem), and computerized measures were obtained and analyzed statistically. an average of 12,412 perikarya and 12,005 myelinated nerve fibers was obtained. approximately 0.7% of the perikarya appeared unmyelinated under lm. about 500 unmyelinated fibers were counted. the cross-sectional area of 1,864 perikarya was 200-650 micron 2. ...19873661110
local brainstem glucose utilization in the squirrel monkey.the 2-deoxy-d-[14c]-glucose method for the measurement of local cerebral glucose utilization (lcgu) in individual brain nuclei and regions has been applied to the squirrel monkey (saimiri sciureus). the determinations were conducted in five conscious, lightly restrained adult, female, colombian squirrel monkeys. local glucose utilization in brainstem structures (lbgu) was highest in nuclei involved in auditory and vestibular functions and in some nuclei involved in general motor activity. the va ...19873664279
animal models of mycoplasma genitalium urogenital infection.male and female animals were inoculated urogenitally with mycoplasma genitalium, recovered originally from men with nongonococcal urethritis. mice, hamsters and male rhesus monkeys (macaca mulatta) were resistant. male cynomolgus monkeys (macaca fascicularis) were not as sensitive as male chimpanzees (pan troglodytes): 9 of 11 developed an obvious genital tract infection, some shedding organisms for more than 18 weeks. m. genitalium was recovered from the blood of two of them when large numbers ...19873667225
distribution of gaba-immunoreactive neurons in the thalamus of the squirrel monkey (saimiri sciureus).a light microscopic study of the cellular localization of gaba in the thalamus of the squirrel monkey (saimiri sciureus) was undertaken by means of the indirect peroxidase-antiperoxidase method using a highly purified antiserum directed against gaba-glutaraldehyde-lysyl-protein conjugate. gaba-immunoreactive cell bodies and axon terminals were visualized in all thalamic nuclei in the squirrel monkey but their relative density varied from one nucleus to the other. at the level of the anterior nuc ...19873670598
encephalomyocarditis virus infection in african green and squirrel monkeys: comparison of pathologic effects.this study compared the pathological effects of experimental encephalomyocarditis virus infection in african green monkeys (cercopithecus aethiops) and squirrel monkeys (saimiri sciureus). african green monkeys died within 5 days post-inoculation and significant changes were limited to moderate to severe multifocal nonsuppurative necrotizing myocarditis. squirrel monkeys were less severely affected and died or were euthanized 4 to 41 days post-inoculation. myocardial and central nervous system c ...19873695400
pathologic changes associated with fatal plasmodium falciparum infection in the bolivian squirrel monkey (saimiri sciureus boliviensis).fatal cases of experimental plasmodium falciparum (indochina i) in bolivian squirrel monkeys (saimiri sciureus boliviensis) were examined by histologic and ultrastructural methods. gross lesions were characterized by hepatosplenomegaly and interstitial pulmonary changes. histologically, there was marked diffuse reticuloendothelial hyperplasia, pulmonary alveolar septal thickening, mesangioproliferative glomerulonephropathy, sequestration of parasitized erythrocytes in deep vascular beds, degener ...19873300388
chesson strain plasmodium vivax in saimiri sciureus boliviensis monkeys.nine saimiri sciureus boliviensis monkeys were inoculated with sporozoites of plasmodium vivax (chesson strain) dissected from anopheles stephensi mosquitoes infected by feeding on blood from infected chimpanzees. the animals were splenectomized 7 days after inoculation. seven animals developed infections with prepatent periods ranging from 12 to 43 days (mean of 19.6 days). parasitemias were low during the first 50 days. maximum parasitemias in 5 animals in which the strain adapted ranged from ...19873309241
experimental infections of simians with human malaria: attempts to infect callithrix penicillata with plasmodium falciparum.after reviewing the use of non-human primates of the old and new worlds for human malaria research, we concluded that another experimental animal which is easily available to use and possible to rear indoors is needed. thus, we studied the susceptibility of the marmoset callithrix penicillata to plasmodium falciparum erythrocytic infections. the marmosets received various p. falciparum human isolates, directly from a patient and from continuous cultures. the palo alto strain, which has been adap ...19873149726
differential dopaminergic innervation of the two pallidal segments in the squirrel monkey (saimiri sciureus).immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. this innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arising from midbrain dopamine cell bodies and running in the lateral hypothalamus. dopaminergic fibers reached the globus pallidus by coursing along its two major output pathways: the l ...19872891410
dissociated response of plasma albumin and transferrin to protein-calorie restriction in squirrel monkeys (saimiri sciureus).the responses of albumin and transferrin to selective nutritional interventions were assessed in 31 infant monkeys. diets were restricted in protein, calories, or both from age 2 to 8 wk (study a) or protein alone from age 4 to 24 wk (study b)--in both cases to prevent growth. transferrin levels in study a were significantly lower than control in all three restricted groups whereas albumin levels were decreased only in both low-protein groups. in study b albumin and transferrin concentrations we ...19873120570
nervus terminalis, olfactory nerve, and optic nerve representation of luteinizing hormone-releasing hormone in primates.the luteinizing hormone-releasing hormone (lhrh) system was examined immunocytochemically in olfactory bulbs of adult monkeys, including two new world species (squirrel monkey, saimiri sciureus and owl monkey, aotus trivirgatus) and one old world species (cynomolgus macaque, macaca fasciculata), and in the brain and nasal region of a fetal rhesus macaque macaca mulatta. lhrh neurons and fibers were found sparsely distributed in the olfactory bulbs in all adult monkeys. there was more lhrh in the ...19873129973
ethanol effects on eeg spectra in monkeys: comparison to morphine and diazepam.the effects of oral administration of 3 doses of ethanol (0.75, 1.0 and 1.5 g/kg) and single doses of morphine (2.5 mg/kg) and diazepam (2.5 mg/kg) on spectral components of the eeg were investigated in the squirrel monkey saimiri sciureus. comparisons of mean spectral power in the 4 frequency bands (2-4 hz, 4-8 hz, 8-16 hz, 16-32 hz) revealed that the lowest dose of ethanol (0.75 g/kg) produced some increase in power in all 4 frequency bands with significant increases in the 8-16 hz band. morph ...19872434316
cytomorphology of the area striata in saimiri sciureus. a golgi study.nissl- and golgi preparations of the brain of the new world monkey saimiri sciureus were used to determine neuronal cell types and their distribution in the primary visual cortex (area striata or area 17). the visual cortex is located occipitally, mainly constituting the cortical surface around the calcarine fissure with six different laminae (total thickness about 1,300 micron). as the prevailing cell types, spiny neurons, such as pyramids and pyramid-like cells, many spiny multipolar cells, gi ...19882457048
experimental chagas' disease (trypanosoma cruzi) in the brazilian squirrel monkey (saimiri sciureus): hematology, cardiology, cellular and humoral immune responses. 19883130317
histochemistry of mucosubstances in brunner's-gland cells and duodenal goblet cells of two new world monkey species (saimiri sciureus and saguinus fuscicollis).duodenal goblet cells and brunner's-gland cells obtained from two species of new world monkeys (saimiri sciureus and saguinus fuscicollis) were studied using conventional histochemical methods and by applying a panel of 17 labelled lectins. the secretions of both goblet and brunner's-gland cells were found to contain neutral mucosubstances, while those of goblet cells also exhibit acid and sulphated carbohydrate components. lectin binding studies allowed a more detailed analysis of the mucus gly ...19883130342
refractoriness of callithrix penicillata red blood cells to plasmodium falciparum in vivo and in vitro.attempts to infect the new world marmot callithrix penicillata with plasmodium falciparum were unsuccessful. attempts were also made to infect red blood cells of c. penicillata and saimiri sciureus with p. falciparum in vitro, and these too were unsuccessful due to a high rate of hemolysis produced by apparently adverse culture conditions. it is concluded that modifications to the existing culture conditions will need to be made before successful parasitemia can be induced in vitro in simian ery ...19883132548
characterization of colonic cellular glycoconjugates in colitis and cancer-prone tamarins versus colitis and cancer-resistant primates.differences in colonic secretory glycoconjugates (ie, mucin) between normal and ulcerative colitis-prone patients have been noted. similar differences may occur in a corresponding primate model, the cotton-top tamarin (ctt), saguinus oedipus, a new world monkey which suffers from spontaneous chronic colitis and colon cancer. lectin reagents were used to characterize and compare colonic cell surface, cytoplasmic, and secretory glycoconjugates of 9 clinically healthy cotton-top tamarins, 7 colitis ...19883132857
purification and properties of squirrel monkey (saimiri sciureus) corticosteroid binding globulin.corticosteroid binding globulin (cbg), a serum glycoprotein which binds glucocorticoids and progestins with high affinity, is widely distributed throughout the animal world. although its charge and size characteristics have largely been conserved across species, we found the behavior of cbg in squirrel monkey (saimiri sciureus) serum during fractionation by polyacrylamide gel electrophoresis or sephadex chromatography was consistent with a molecule about twice the size of that found in most spec ...19883132970
anatomical brain asymmetries in new world and old world monkeys: stages of temporal lobe development in primate evolution.relatively large (n = 20-30) samples of formalin-fixed brain specimens from five old and new world monkey species were examined in a study measuring anatomical temporal-lobe asymmetries. linear measurements of the length of the sylvian fissure were taken on each cerebral hemisphere to evaluate lateral differences related to development of auditory association cortex. the results indicate significantly greater sylvian fissure length on the left hemisphere than on the right hemisphere in four of t ...19883136655
responses of single neurons in the parietoinsular vestibular cortex of primates.1. neurons activated by stimulation of the horizontal and/or vertical vestibular semicircular canals were recorded in the parietoinsular vestibular cortex in four awake java monkeys (macaca fascicularis) and three squirrel monkeys (saimiri sciureus). steady tilt in darkness or during illumination of a vertically striped cylinder or of the normal laboratory surroundings did not lead to a significant change in pivc neuron activity. thus vestibular input to this cortical region seems to be restrict ...19883149165
protection against fatal klebsiella pneumoniae sepsis in the squirrel monkey saimiri sciureus after immunization with a capsular polysaccharide vaccine.an anti-klebsiella pneumoniae k5a capsular polysaccharide vaccine was evaluated as a preventive approach for protecting squirrel monkeys, saimiri sciureus, in our breeding colony. based on an 8-month vaccination schedule over a period of more than two years, this vaccine, regardless of the animal's age, resulted in a reduction of this particular bacterial infection and its generally associated fatal outcome. igg antibody responses in naive and vaccinated animals were monitored over an extended p ...19883048318
long-term protection of squirrel monkeys (saimiri sciureus) against plasmodium falciparum challenge inoculations after various time intervals.when used as an experimental host for plasmodium falciparum, the squirrel monkey saimiri sciureus, intact or splenectomized, develops a significant, long-lasting, protective immunity against the blood stages of this parasite. in the present study, this length of protection after a single initial infection was determined by test infections carried out at varying intervals of time in 26 splenectomized animals. an initial period of about 7 months was observed, which was characterized by a marked re ...19883070542
[pregnancy diagnosis by the ultrasonographical device and observation of fetal growth in the squirrel monkey (saimiri sciureus)].this paper describes usefulness of the ultrasonographical device (usd) for the diagnosis of pregnancy and the observation of fetal growth in the squirrel monkeys (saimiri sciureus) conceived under group breeding conditions. pregnancy was diagnosed on the basis of the detection of gestational sac (gs) in the uterus. the gs was first detected 127 +/- 10 days before delivery. the heart beat of embryo was detected around 114 days before delivery. it was able to judge conditions of fetal growth by me ...19883071469
the dopaminergic innervation of monkey prefrontal cortex: a tyrosine hydroxylase immunohistochemical study.the distribution of tyrosine hydroxylase (th)-immunoreactive fibers was characterized immunohistochemically in the prefrontal cortical regions of both old world cynomolgus monkeys (macaca fascicularis) and new world squirrel monkeys (saimiri sciureus). in both species, differences in the density and/or laminar distribution of th-labeled fibers were detected both across and within almost every prefrontal cytoarchitectonic region. in cynomolgus monkeys, areas 9 and 24 had the greatest density of t ...19882899447
neurons of the subthalamic nucleus in primates display glutamate but not gaba immunoreactivity.immunohistochemical studies undertaken with a highly specific antiserum raised against gamma-aminobutyric acid (gaba)-glutaraldehyde-lysyl-protein conjugate showed that cell bodies of the subthalamic nucleus in the squirrel monkey (saimiri sciureus) were closely surrounded by several gaba-positive terminals but were not themselves immunoreactive. in contrast, after incubation with a monoclonal antibody directed against carbodiimide-fixed glutamate, virtually all cell bodies of the subthalamic nu ...19882900056
effect of human gamma interferon on yellow fever virus infection.we studied yellow fever virus infection in two species of monkey: saimiri sciureus (squirrel monkeys) and macaca mulatta (rhesus monkeys). human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. interferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus mo ...19883152785
[ultrastructural observations of follicular oocytes inseminated in vitro in squirrel monkeys (saimiri sciureus)].the ultrastructure of squirrel monkey (saimiri sciureus) follicular oocytes inseminated in vitro was studied at the endocrine research center of michigan state university in the united states. adult female squirrel monkeys were induced to ovulate with fsh-hcg, followed by laparoscopy 16 hours after hcg to collect ovarian follicular oocytes. a total of 45 oocytes were inseminated 21 hours after recovery by adding sperm collected by electroejaculation, followed by insemination culture for 24 hours ...19883171270
efficacy of ivermectin against natural infection of strongyloides spp. in squirrel monkeys (saimiri sciureus). 19883184861
elevation in plasma glucagon levels in response to stress in squirrel monkeys: comparisons of two subspecies (saimiri sciureus boliviensis and saimiri sciureus sciureus).bolivian (bo) and brazilian (br) squirrel monkeys (sms) were captured and restrained to determine patterns of glucagon and glucose response. in both subspecies, plasma glucagon and glucose levels rose rapidly in response to restraint procedures; glucagon levels in brsms and glucose levels in both subspecies returned to basal values in 15 minutes. the magnitude of the glucagon and glucose responses differed significantly between bosms and brsms.19883193450
erp responses to ethanol and diazepam administration in squirrel monkeys.the effects of oral administration of two doses of ethanol (0.75 and 1.5 g/kg) and a single dose of diazepam (2.5 mg/kg) on electrophysiological responses to an event related potential (erp) paradigm were investigated in the squirrel monkey saimiri sciureus. a passive auditory "oddball plus novel" tone sequence was utilized to elicit n1, p2, n2, and p3-like components which resembled waveforms obtained from human subjects under the same conditions. ethanol at both doses was found to produce a si ...19883228483
nocturnal vocalizations by squirrel monkeys (saimiri sciureus). 19883254847
corticotropin-releasing factor in olivocerebellar climbing-fiber system of monkey (saimiri sciureus and macaca fascicularis): parasagittal and regional organization visualized by immunohistochemistry.an antiserum directed against the human form of corticotropin-releasing factor (crf) was utilized for immunohistochemical visualization of the distribution of this peptide in the inferior olivary nucleus and cerebellum of 2 monkey species (saimiri sciureus, macaca fascicularis). colchicine pretreatment was not used. in both species, immunoreactivity was evident in the vast majority of neurons in the inferior olivary nucleus, with perikarya in the medial accessory olive exhibiting especially inte ...19883263473
distribution of corticotropin-releasing-factor-like immunoreactivity in brainstem of two monkey species (saimiri sciureus and macaca fascicularis): an immunohistochemical study.immunohistochemical methods were utilized to systematically map the distribution of corticotropin-releasing-factor-like immunoreactivity (crf-li) in the diencephalon, mesencephalon, and rhombencephalon of two monkey species (saimiri sciureus and macaca fascicularis). a primary antiserum directed against the human form of the peptide was utilized. immunoreactive neuronal perikarya and processes were evident in numerous areas, and the distributions of these elements were similar for the two specie ...19883265422
glomerulopathy in squirrel monkeys with acute plasmodium falciparum infection.the renal pathology of 9 squirrel monkeys (saimiri sciureus) with acute plasmodium falciparum infection was studied by light and electron microscopy. endocapillary proliferative glomerulonephritis was the major pathological change observed. the peroxidase anti-peroxidase method demonstrated the presence of igg, igm, and p. falciparum antigens in the mesangium and basement membrane. these findings were consistent with those seen in humans with acute p. falciparum infection and indicates that squi ...19883277466
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