Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| renal abscess and fungemia due to torulopsis glabrata: successful treatment with drainage and fluconazole. | 1994 | 8054422 | |
| a rapid colorimetric assay of killer toxin activity in yeast. | the pale yellow redox indicator 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) is reduced to a dark blue end-product, mtt-formazan, by the mitochondrial dehydrogenases of living cells. mtt reduction can be measured spectrophotometrically at a wavelength of 570 nm and a method is described to assay the cidal activity of williopsis mrakii killer toxin against sensitive cells of candida glabrata. the mtt assay is rapid, quantitative and compares favourably with traditional plat ... | 1994 | 8056291 |
| dominance of metallothionein in metal ion buffering in yeast capable of synthesis of (gamma ec)ng isopeptides. | the relationship of yeast metallothionein (mt) and (gamma ec)ng isopeptides (phytochelatins) in metal ion buffering was assessed. the effect of constitutive expression of yeast metallothionein (mt) genes on accumulation of metal-(gamma ec)ng isopeptide (phytochelatin) complexes was analyzed in candida glabrata and schizosaccharomyces pombe cultures incubated in the presence of cadmium salts. constitutive expression of the saccharomyces cerevisiae mt (cup1) gene inhibited the accumulation of meta ... | 1994 | 8063718 |
| rapid presumptive identification of medically relevant yeasts to the species level by polymerase chain reaction and restriction enzyme analysis. | a method for the rapid presumptive differentiation of a panel of 12 clinically relevant yeasts to the species level was developed on the basis of evaluation by the polymerase chain reaction (pcr) of the gene coding for the small ribosomal subunit 18s-rrna. the method involved restriction enzyme analysis of pcr products obtained with primers common to all fungi. using six restriction enzymes, alui, bani, bbsi, draii, eco147i and nhei, characteristic pcr-restriction enzyme patterns were obtained f ... | 1994 | 8064542 |
| mixed cu+ and zn2+ coordination in the dna-binding domain of the amt1 transcription factor from candida glabrata. | amt1 is the transcription factor required for cu-induced expression of metallothionein genes in the yeast candida glabrata. the copper-binding, dna-binding domain of amt1 has been purified after expression of an amt1 synthetic gene in bacteria and was confirmed as active in a gel shift assay. the cu-activated amt1 was shown to contain a cu(+)-thiolate tetracopper center and a single zn2+ site. amt1 is purified as a cu-zn protein from bacterial cultures grown in the presence of cuso4. chemical an ... | 1994 | 8068632 |
| correlation between antifungal susceptibility testing of candida isolates from patients with hiv infection and clinical results after treatment with fluconazole. | in an open-label controlled study 23 hiv-infected patients (cdc iv a-e) with documented oropharyngeal candidosis were treated with 100 mg fluconazole orally over 5 days (53 episodes; 1-6 treatments/patient). efficacy data were compared with a control group of 21 patients who received treatment for 10-21 days with 100 mg fluconazole for candidosis. candida isolates were repeatedly recovered from patients before and after treatment with fluconazole and antifungal susceptibility testing (microbroth ... | 1994 | 8070927 |
| the contribution of electrostatic forces to the process of adherence of candida albicans yeast cells to substrates. | the contribution of electrostatic interactions to the adherence process of candida albicans and other candida species was investigated by mixing cationic or anionic exchange resins possessing free -coo- or -nh+4 groups, respectively, on their surface. the adherence process of yeast cells to the anionic exchange resin is a saturable event that is essentially complete by 60 min. there is no measurable interaction of yeast cells with the cationic exchange resin. all clinical isolates of c. albicans ... | 1994 | 8076801 |
| controlled clinical evaluation of isolator and esp aerobic blood culture systems for detection of bloodstream infections. | a controlled clinical evaluation comparing the isolator system (wampole laboratories, cranbury, n.j.) and the esp 80a blood culture bottle in the automated esp system (difco laboratories, detroit, mich.) was performed with 10,535 blood culture sets from patients with suspected septicemia. of 1,150 positive cultures, 844 positive cultures from 285 patients with 394 septic episodes fulfilled the study criteria for minimum blood sample requirements in each system and clinical significance of isolat ... | 1994 | 8077401 |
| the structure of the small mitochondrial dna of kluyveromyces thermotolerans is likely to reflect the ancestral gene order in fungi. | mapping the 23-kb circular mitochondrial dna from the yeast kluyveromyces thermotolerans has shown that only one change occurs in the gene order in comparison to the 19-kb mtdna of candida (torulopsis) glabrata. sequence analysis of the mitochondrially encoded cytochrome oxidase subunit 2 gene reveals that despite their conserved gene order, the two small genomes are more distantly related than larger mtdna molecules with multiple rearrangements. this result supports a previous observation that ... | 1994 | 8083884 |
| fluconazole susceptibilities of candida species and distribution of species recovered from blood cultures over a 5-year period. | the distribution and fluconazole susceptibilities of candida species isolated over a 5-year period were investigated. susceptibilities were determined by using a new microtiter procedure and the national committee for clinical laboratory standards (nccls) proposed standard. the new method correlated well with the nccls proposed standard and gave very clear end points. results indicate that there are species-related differences in mics as reflected in the mics for 90% of species tested. candida a ... | 1994 | 8092849 |
| frequency, pathogenicity and microbiologic outcome of non-candida albicans candiduria. | a retrospective review of urine cultures obtained from patients at the university of illinois hospital revealed that the frequency of isolation of non-albicans candida species increased significantly from 1990 to 1991 (p = 0.0003), while the frequency of isolation of candida albicans species decreased significantly (p = 0.0006). patients with urine cultures positive for non-albicans candida species of torulopsis glabrata during 1991 were identified for review. sixty-seven patients were eligible ... | 1994 | 7957265 |
| frequency and significance of drug resistance in vulvovaginal candidiasis. | the rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for candida species. torulopsis glabrata was associated more frequently than c. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0.003, chi 2 test). as evaluated by the results of susceptibility testing, c. albicans isolates were uniformly sensitive to the antifungals tested, whereas 7.5% (3/40) of t. glabrata ... | 1994 | 7959341 |
| clinical and microbiological characteristics of symptomatic vulvovaginal candidiasis in hiv-seropositive women. | to evaluate the clinical and microbiological characteristics of symptomatic vaginal candidiasis in human immunodeficiency virus (hiv)-seropositive women attending a gynaecologic outpatient clinic for sexually transmitted diseases (stds). | 1994 | 7959713 |
| treatment of disseminated torulopsis glabrata infection with do870 and amphotericin b. | torulopsis glabrata, an opportunist pathogen in immunosuppressed patients, is resistant to many antifungal agents, and there are no established treatment regimens for this organism. the mouse model was used to evaluate treatment with do870, amphotericin b, fluconazole, and their combination. mice were immunosuppressed with 5 mg of gold sodium thiomalate given intraperitoneally 1 day prior to intravenous infection with 10(8) t. glabrata cells. treatment with a new antifungal triazole, do870, at d ... | 1994 | 7979293 |
| comparative in vitro activity of antimycotic agents against pathogenic vaginal yeast isolates. | although numerous antimycotic agents are available for the treatment of yeast vaginitis there is little comparative data on the in vitro activity of these drugs. in the present two-part study, in vitro macro-broth dilution sensitivity tests were performed on a total of 377 clinical vaginal yeast isolates of nine different species. antimycotics surveyed included amphotericin b, 5-fluorocytosine and eight azole derivatives. results show that all vaginal candida albicans isolates were uniformly sen ... | 1994 | 7983571 |
| rapid detection and identification of candida albicans and torulopsis (candida) glabrata in clinical specimens by species-specific nested pcr amplification of a cytochrome p-450 lanosterol-alpha-demethylase (l1a1) gene fragment. | pcr of a candida albicans cytochrome p-450 lanosterol-alpha-demethylase (p450-l1a1) gene segment is a rapid and sensitive method of detection in clinical specimens. this enzyme is a target for azole antifungal action. in order to directly detect and identify the clinically most important species of candida, we cloned and sequenced 1.3-kbp fragments of the cytochrome p450-l1a1 genes from torulopsis (candida) glabrata and from candida krusei. these segments were compared with the published sequenc ... | 1994 | 7989540 |
| evaluation of a novel colorimetric broth microdilution method for antifungal susceptibility testing of yeast isolates. | a comparative evaluation of two broth microdilution methods for antifungal susceptibility testing of 600 clinical yeast isolates (candida spp., torulopsis glabrata, and cryptococcus neoformans) against amphotericin b, fluconazole, and flucytosine (5fc) was conducted. microdilution testing was performed according to national committee for clinical laboratory standards (nccls) recommendations (nccls document m27-p). by using the growth control for comparison, reference microdilution mic endpoints ... | 1994 | 7989555 |
| in vitro infection of human fetal membranes with candida species. | to assess whether candida species can penetrate intact fetal membranes under in vitro conditions, candida albicans, candida tropicalis, candida guilliermondii, candida pseudotropicalis and candida glabrata were inoculated onto the surface of the maternal side of the membranes obtained from 4 pregnant women undergoing repeat cesarean section. after incubation under culture conditions, membranes were evaluated by histological examination. c. albicans inoculated onto the maternal side penetrated an ... | 1994 | 8005544 |
| use of amphotericin b during pregnancy: case report and review. | unlike the situation with many antimicrobial agents, there is limited experience with the use of amphotericin b during pregnancy. although reports of fungal infections during pregnancy have been published, few describe fungemia with either candida or torulopsis species. we present a case of fungemia due to torulopsis glabrata that occurred during pregnancy and that was treated with amphotericin b. drug concentrations were measured in placental tissue, cord serum, and infant serum at delivery. al ... | 1994 | 8011817 |
| misidentification of clinical yeast isolates by using the updated vitek yeast biochemical card. | the vitek yeast biochemical card (ybc) is widely used as a rapid identification (ri) (within 48 h) system for clinical yeast isolates. we compared the ri results obtained by the ybc technique with matched results obtained with the api 20c system. the ri of germ tube-negative yeasts isolated from 222 clinical specimens was performed with the ybc system, and the results were compared with those of standard identifications obtained by using the api 20c system and morphology, with additional biochem ... | 1994 | 7883873 |
| pcr identification of four medically important candida species by using a single primer pair. | a single pair of primers was used in a pcr assay to amplify and identify the dnas from four medically important candida species: c. albicans, c. parapsilosis, c. tropicalis, and c. (torulopsis) glabrata. the report describes the first successful amplification of a chitin synthase-specific fragment from the four candida species responsible for more than 90% of all cases of neonatal candidemia. the primer pair sequence was based on that from the c. albicans chitin synthase gene, chs1 (j. au-young ... | 1994 | 7883883 |
| fungal infection of ventriculoperitoneal shunts in children. | infection is still the most common complication of shunt procedures in children. however, fungal infection is still considered to be rare. we found that fungi accounted for 17% of shunt infections (8 of 48) in a retrospective study. all of the patients were premature babies and had received a ventriculoperitoneal shunt because of hydrocephalus. the clinical manifestations were subtle and insidious. the time of onset of infection ranged from 1 month to 1 year after the insertion of the shunt. exa ... | 1994 | 7888533 |
| trends and sources of nosocomial fungaemia. | concurrent surveillance of blood culture isolates in a 1000-bed tertiary care hospital over a 7-year period from 1986 to 1993 identified 102 episodes of nosocomial fungaemia, representing 6.6% of all episodes of nosocomial bloodstream infections and 0.49/1000 admissions. no significant change in the frequency, rate, source or microbial aetiology of nosocomial fungaemia occurred over the 7-year period. candida albicans accounted for 74%, followed by candida (torulopsis) glabrata (8%), c. parapsil ... | 1994 | 7898515 |
| [candida glabrata pneumonia in a non-immunosuppressed patient: diagnostic imaging with digital luminescence radiography and ct]. | pneumonias caused by candida glabrata are extremely rare and occur almost exclusively in immunocompromised patients. we report an atypical case of candida glabrata pneumonia in a non-immunocompromised patient and describe the imaging findings on digital radiography and computed tomography. | 1994 | 7918708 |
| assessment of microbial growth in intravenous immune globulin preparations. | the ability of intravenous immune globulin (ivig) products to support bacterial and yeast growth was studied. microtiter plates containing preparations of eight commercially available ivig products were inoculated with 10(5) colony-forming units (cfus) of bacteria per milliliter or 10(3) cfus of yeast cells per milliliter. the organisms used were candida albicans, torulopsis glabrata, pseudomonas aeruginosa, staphylococcus epidermidis, and klebsiella pneumoniae. the plates were incubated at 3, 2 ... | 1994 | 7942893 |
| epidemiology of oral candidiasis in hiv-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance. | to study the epidemiology of oral candidiasis and the effect of treatment of thrush in human immunodeficiency virus (hiv)-infected patients. | 1994 | 7942935 |
| cross-sectional study of the susceptibility of candida isolates to antifungal drugs and in vitro-in vivo correlation in hiv-infected patients. | to investigate (1) the frequency of clinical resistance to oral polyenes or azole treatment for oral candidiasis, (2) the frequency of resistant in vitro candida strains, (3) the relationship between the susceptibilities of in vitro candida species and in vivo status in hiv patients. | 1994 | 7946104 |
| the efficacy of fluconazole in treating prosthetic valve endocarditis caused by candida glabrata: report of a case. | a case of active prosthetic valve infective endocarditis (pve) due to candida glabrata was successfully treated by the systemic administration of fluconazole. a 66-year-old japanese man with infective endocarditis of unknown etiology underwent aortic and mitral valve replacement to treat severe aortic and mitral regurgitation associated with multiple organ failure. postsurgical cultures of arterial blood were repeatedly positive for c. glabrata, and therefore fluconazole was administered either ... | 1994 | 7949778 |
| in vitro susceptibility of 545 isolates of candida spp. to four antifungal agents. | the in vitro susceptibility to amphotericin b, fluconazole, itraconazole and ketoconazole of 545 candida strains from patients treated at the university hospital of the canaries was determined by means of a microdilution test. the distribution of the species was as follows: candida albicans (342), candida tropicalis (70), candida glabrata (68), candida parapsilosis (65). of candida albicans isolates, 8.5% and 7.6% showed resistance to itraconazole and fluconazole respectively. of c. tropicalis i ... | 1994 | 7739661 |
| growth inhibition of pathogenic yeasts by pseudomonas aeruginosa in vitro: clinical implications in blood cultures. | the interaction between yeasts and bacteria may have clinical implications in polymicrobial septicaemia. the in vitro effect of pseudomonas aeruginosa on five pathogenic yeast species, candida albicans, candida tropicalis, candida parapsilosis, candida glabrata and cryptococcus neoformans, was investigated. yeast inhibition assays were performed in an aerobic blood culture medium, inoculated with yeast cells (inoculum 1-10 cfu ml-1) and bacterial cells (inoculum 10-10(7) cfu ml-1). interactions ... | 1994 | 7746293 |
| [hepatic candidiasis caused by candida glabrata]. | the incidence of disseminated candidiasis is increasing. liver involvement is frequent but rarely diagnosed. the authors report a case of disseminated candidiasis due to candida glabrata with liver metastases. the presence of hepatic lesions was diagnosed by ct scan and parasitological examination of liver abscess contents obtained by ct-scan-directed puncture-aspiration. the outcome was favorable with amphotericin-b (cumulative dose of 1 g) and flucytosin. aspects of hepatic involvement in diss ... | 1994 | 7802437 |
| clinically significant mucosal candidiasis resistant to fluconazole treatment in patients with aids. | eight cases of severe mucosal candidiasis in patients with aids who were taking fluconazole at a dosage of 400-800 mg/d are described. candida albicans alone or in conjunction with torulopsis glabrata or candida stellatoidea was isolated from each patient. in vitro susceptibility testing demonstrated resistance to fluconazole in all eight cases. all tested isolates were susceptible to amphotericin b, and six of eight isolates tested were susceptible to itraconazole. all individuals were severely ... | 1994 | 7803632 |
| antifungal activity of a new triazole, d0870, compared with four other antifungal agents tested against clinical isolates of candida and torulopsis glabrata. | d0870 is a new triazole agent with potent, broad-spectrum antifungal activity. we investigated the in vitro activity of d0870, fluconazole, itraconazole, amphotericin b, and 5-fluorocytosine (5fc) against 319 clinical isolates of candida spp. and torulopsis glabrata. in vitro susceptibility testing was performed using a microdilution broth method performed according to nccls guidelines. d0870 was very active (mic90 of 0.12 microgram/ml and 0.5 microgram/ml at 24 and 48 h incubation, respectively ... | 1994 | 7805359 |
| an experimental model for study of candida survival and transmission in human volunteers. | in order to determine the potential for cross-transmission of candida spp. between health-care workers and patients, the survival of clinical isolates of five species of candida on the palms of human volunteers was tested. one hundred microliters of a mcfarland 1.0 density suspension (5 x 10(5) cfu) from an overnight culture of candida albicans, candida krusei, candida parapsilosis, candida tropicalis and candida glabrata was used as inoculum. the degree of hydrophobicity of the different candid ... | 1994 | 7805688 |
| comparative study of broth macrodilution and microdilution techniques for in vitro antifungal susceptibility testing of yeasts by using the national committee for clinical laboratory standards' proposed standard. | a comparative study of broth macro- and microdilution methods for susceptibility testing of fluconazole, itraconazole, flucytosine, and amphotericin b was conducted with 273 yeasts. the clinical isolates included 100 candida albicans, 28 candida tropicalis, 25 candida parapsilosis, 15 candida lusitaniae, 15 candida krusei, 50 cryptococcus neoformans var. neoformans, 25 torulopsis (candida) glabrata, and 15 trichosporon beigelii strains. both methods were performed according to the national commi ... | 1994 | 7814488 |
| comparison of broth macrodilution, broth microdilution, and e test antifungal susceptibility tests for fluconazole. | a comparison of the e test, the broth microdilution test, and the reference broth macrodilution susceptibility test of the national committee for clinical laboratory standards for fluconazole susceptibility testing was performed with 238 clinical isolates of candida species and torulopsis (candida) glabrata. an 80% inhibition endpoint mic was determined by the reference broth macrodilution method after 48 h of incubation. the mics obtained by the two study methods were read after 24 and 48 h of ... | 1994 | 7814531 |
| fluconazole, itraconazole and ketoconazole in vitro activity against candida spp. | the in vitro activity of fluconazole, itraconazole and ketoconazole against 625 candida yeast strains from patients treated at the university hospital of the canaries, by means of a micromethod of dilution in broth enriched with yeast nitrogen base (ynb), and buffered to ph7, has been assessed. species distribution was as follows: candida albicans (388), candida tropicalis (84), candida glabrata (84), candida parapsilosis (69). our results show 10.0% and 8.8% of c. albicans resistant to itracona ... | 1994 | 7830098 |
| candidiasis caused by candida glabrata in the forestomachs of a calf. | a female japanese black calf suffering from diarrhoea was treated with six different antibiotics for 9 days. the diarrhoea worsened and the calf was killed when 17 days old. at necropsy, the mucosal surface of the forestomachs showed diffuse haemorrhagic necrosis and pseudomembrane formation. candida glabrata infection was diagnosed histologically, immunohistochemically, and by isolation and examination of the yeast. the intensive antibiotic treatment was considered to have been a predisposing o ... | 1994 | 7836573 |
| efficacy of oral amphotericin b in aids patients with thrush clinically resistant to fluconazole. | reports of thrush clinically refractory to azoles in aids patients are increasing with the more widespread use of these agents. we studied our own oral preparation of amphotericin b in the treatment of two aids patients who developed oral thrush due to candida glabrata after prolonged fluconazole use. improvement occurred in both in less than 1 week, with eventual clearing and absence of side effects. oral amphotericin b may have advantages over alternatives for this increasing problem. | 1994 | 7844704 |
| high prevalence of antifungal resistance in candida spp. from patients with aids. | three hundred and forty-eight isolates of candida spp. from patients treated at a regional infectious diseases unit for aids, immunocompromised patients admitted to the hope hospital and isolates referred from around the north west of england were tested for their in-vitro susceptibility to amphotericin b, fluconazole and flucytosine using standardized methods. candida albicans comprised 73% of isolates, candida glabrata 10% and candida parapsilosis 7%. ninety-six percent of isolates were suscep ... | 1994 | 7706161 |
| antifungal prophylaxis with low-dose fluconazole during bone marrow transplantation. the bone marrow transplantation team. | the present study investigated the prophylactic efficacy of fluconazole at 100-200 mg/day against invasive fungal infections during bone marrow transplantation (bmt). during july 1990 to december 1991, all bmt recipients received antifungal prophylaxis with fluconazole at either 200 mg/day or 100 mg/day. historical controls were those that received no antifungal prophylaxis (january 1989 to june 1990). fungemia occurred in 4 of 112 fluconazole recipients and 8 of 79 controls (p < 0.05) prior to ... | 1994 | 7711669 |
| the in vitro proteolytic and saccharolytic activity of candida species cultured in human saliva. | the proteolytic and saccharolytic activity of 4 candida species was investigated in batch cultures of pooled, human mixed saliva supplemented with glucose. all the candida species investigated (candida albicans, candida tropicalis, candida glabrata and candida krusei) demonstrated a marked growth in saliva with a concomitant reduction in ph from about 7.5 to 3.3, within 72 h. isotachophoretic analysis of the culture supernatant revealed the presence of a variety of acid anions of which pyruvate ... | 1994 | 7478763 |
| inhibition of fungal growth by pseudomonas aeruginosa and pseudomonas cepacia isolated from patients with cystic fibrosis. | this study was undertaken because of the infrequency of infections due to candida species in patients with cystic fibrosis despite their extensive treatment with broad-spectrum antibiotics. in vitro susceptibility studies revealed significant inhibition of 11 strains of fungi known to infect human beings by 10 strains of pseudomonas aeruginosa and nine strains of pseudomonas cepacia isolated from the sputum of patients with cystic fibrosis. the fungi were candida krusei, candida keyfr, candida g ... | 1994 | 7522262 |
| management of candiduria. | candiduria, due to candida albicans, candida glabrata and other organisms, has increased in frequency due the use of broad-spectrum antibacterials, immunosuppressive agents and other factors. the optimal management of candiduria is unknown due to an unclear definition of fungal urinary tract infection and the lack of well-designed clinical trials. removal of urinary catheters, ruling out obstruction/stones and documenting presence of post-void residuals are useful in the management of candiduria ... | 1994 | 18611602 |
| differential and enrichment media for selective culture and recognition of yeast species from clinical material. | an enrichment medium was developed and evaluated for isolation of fluconazole-resistant minority yeast species in a hospital setting. the enrichment medium was made by adding fluconazole (10 micrograms/ml) to yeast nitrogen base/glucose broth. under laboratory conditions the broth permitted detection of 20 of 20 candida krusei isolates and 20 of 20 candida glabrata isolates in mixtures with candida albicans even when the candida albicans cells outnumbered those of the other species by 1000:1. re ... | 1995 | 7556229 |
| nosocomial torulopsis glabrata fungemia with shock in a pregnant woman successfully treated with high doses of fluconazole and delivery of healthy child. | 1995 | 7562024 | |
| re: fluconazole treatment in torulopsis glabrata upper urinary tract infection causing ureteral obstruction. | 1995 | 7563370 | |
| auxacolor, a new commercial system for yeast identification: evaluation of 182 strains comparatively with id 32c. | the incidence of deep candidiasis, particularly in immunocompromised patients, and the emergence of less sensitive yeast species to new antifungal agents explain the interest of their rapid identification. a new identification system, auxacolor (sanofi diagnostics pasteur), has been evaluated, comparatively to id 32c strip taken in reference (biomérieux sa). these systems include respectively 13 and 29 carbohydrate assimilation tests. one hundred and sixty-nine strains belonging to 17 common yea ... | 1995 | 7574109 |
| antigenic and functional conservation of an integrin i-domain in saccharomyces cerevisiae. | we sought evidence for precursors of the leukocyte integrin subunits alpha m and alpha x among unicellular eukaryotes such as saccharomyces cerevisiae. chromatography of cytosolic extracts of saccharomyces cerevisiae on an affinity matrix coupled to bu-15, a monoclonal antibody that recognizes alpha x, revealed a band of m(r) > 205 kda under nonreducing conditions. screening a lambda gt11 library of s. cerevisiae dna with bu-15 (anti-alpha x) and anti-mo1 (anti-alpha m) led to the isolation of a ... | 1995 | 7582869 |
| comparison of fluconazole, amphotericin b and flucytosine in treatment of a murine model of disseminated infection with candida glabrata in immunocompromised mice. | candida glabrata is an emerging opportunist pathogen in immunosuppressed patients. c. glabrata is resistant to many antifungal agents and until recently, there have been no standard treatment regimens for this organism. a mouse model was established using mice immunosuppressed with 5 fluorouracil to evaluate amphotericin b, flucytosine, fluconazole and their combinations to treat an intravenously induced c. glabrata infection. treatment with fluconazole, flucytosine, amphotericin b or a combinat ... | 1995 | 7592176 |
| synergy of fluconazole with human monocytes or monocyte-derived macrophages for killing of candida species. | possible synergy between fluconazole and monocyte-derived macrophages (mdm) for significant killing of candida species and between fluconazole and monocytes for increased candidacidal activity were studied. human serum in test medium (rpmi 1640 with 10% fresh autologous human serum) was highly fungistatic for candida species. fluconazole in test medium, even at high concentrations, was not fungicidal. monocytes alone were fungicidal for all candida species and synergized with fluconazole for inc ... | 1995 | 7594731 |
| antimicrobial prophylaxis in bone marrow transplantation. | to review the efficacy of antimicrobial prophylaxis in bone marrow transplantation. | 1995 | 7598303 |
| fungal feeding-line infections: beware the eyes and teeth. | twenty-four fungal feeding-line infections occurred in 17 patients during 1984-1992. thirteen were receiving long-term home parenteral feeding and, in them, the first infection occurred after a median of 30 months (range 1-120) continuous feeding with a line that had been in situ for a median of 20 months (range 1-37). four were receiving short-term feeding through a line that had been inserted 1-2 months previously. at the time of the first infection all patients were febrile and most were anae ... | 1995 | 7636818 |
| in vitro susceptibility of candida species isolated from patients with haematological malignancies. | candida spp. (83 isolates including c. (torulopsis) glabrata) were tested in vitro for their susceptibility to 5-fluorocytosine, amphotericin b, ketoconazole, itraconazole, fluconazole, and miconazole. the yeasts were isolated from clinical specimens, mostly from the lower respiratory tract, of 30 oncologic patients, 27/30 with haematological malignancies, during a 6-month period (december 1991-may 1992). minimal inhibitory concentration (mic) and minimal fungicidal concentration (mfc) values of ... | 1995 | 7637683 |
| acalculous candidal cholecystitis: a previously unrecognized complication after cardiac transplantation. | acalculous cholecystitis is a life-threatening complication in critically ill surgical patients. whereas candida albicans and torulopsis glabrata have been reported as the primary pathogens in 14 previous cases of acalculous cholecystitis, we report the first case of candida parapsilosis as a biliary pathogen in a patient after cardiac transplantation. although cardiac transplant recipients often have many of the risk factors for acalculous candidal cholecystitis, including major surgery, immuno ... | 1995 | 7639242 |
| in vitro activity of amphotericin b, flucytosine and fluconazole against yeasts causing bloodstream infections. | the in vitro activity of amphotericin b, flucytosine and fluconazole against 95 yeasts causing fungemia in a single institution over the last eight years was determined by a broth macromethod recommended by the national committee for clinical laboratory standards. all strains were inhibited by amphotericin b concentrations of < or = 1 microgram/ml. with flucytosine in most species the mic50 was between 0.12 and 0.25 microgram/ml and the mic90 was between 0.25 and 1 microgram/ml. one exception wi ... | 1995 | 7649205 |
| bilateral fungal epididymo-orchitis with abscess. | we present a unique case of bilateral fungal epididymo-orchitis with abscess formation due to torulopsis glabrata in a nonimmunosuppressed patient with a neurogenic bladder. this case highlights the risk factors for fungal infections of the urinary tract and the difficulty with their management. | 1995 | 7660522 |
| uptake of 14c-chlorhexidine gluconate by saccharomyces cerevisiae, candida albicans and candida glabrata. | uptake of radiolabelled chlorhexidine gluconate (14c-chg) to saccharomyces cerevisiae, candida albicans and c. glabrata was very rapid and near maximal within 30 s. the organism, s. cerevisiae, most sensitive to the lethal action of chlorhexidine, took up significantly more biocide than the other organisms. cells from cultures of different ages took up different amounts of 14c-chg. | 1995 | 7662332 |
| the pattern of fungal infections in critically ill surgical patients. | there continues to be difficulty making the clinical distinction between fungal colonization and systemic infection in critically ill surgical patients. this distinction is important, given the potential risks of aggressive antifungal therapy. in order to evaluate the significance of fungal infections by various sites, we retrospectively reviewed the clinical courses of patients with cultures positive for fungi (candida species or torulopsis glabrata) in the sicu of lac + usc medical center from ... | 1995 | 7668455 |
| fungal endocarditis. | fungal endocarditis has become an important infection associated with medical progress and a modern lifestyle. the most common organisms isolated from patients with fungal endocarditis are: aspergillus spp.; candida spp. and torulopsis glabrata. men are more frequently affected than women and predisposing factors include: previous cardiac surgery, antibiotic use and hyperalimentation, long-term i.v. catheters. common clinical findings in patients with endocarditis include: fever, changing murmur ... | 1995 | 7671932 |
| fluconazole resistance due to energy-dependent drug efflux in candida glabrata. | we report on the mechanism of fluconazole resistance in candida glabrata from a case of infection in which pre- and posttreatment isolates were available for comparison. the resistant, posttreatment isolate was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. resistance was due to reduced levels of accumulation of [3h]fluconazole rather than to changes at the level of ergosterol biosynthesis. studies with metabolic or respiratory inhibitors showed th ... | 1995 | 7486903 |
| evaluation of the auxacolor system, a new method of clinical yeast identification. | to compare the auxacolor yeast identification system with the api 20c system. | 1995 | 7490311 |
| in vitro and in vivo antifungal activities of du-6859a, a fluoroquinolone, in combination with amphotericin b and fluconazole against pathogenic fungi. | du-6859a is an investigational fluoroquinolone agent with potent bactericidal activity, but by itself it has no antifungal activity. when combined with amphotericin b (amb), however, du-6859a clearly enhanced the in vitro antifungal activity of amb against candida albicans, candida tropicalis, candida krusei, candida glabrata, and cryptococcus neoformans in microdilution checkerboard studies. positive interactions of du-6859a with amb against aspergillus fumigatus were dependent on the medium us ... | 1995 | 7492096 |
| controlled evaluation of bact/alert standard anaerobic and fan anaerobic blood culture bottles for the detection of bacteremia and fungemia. | fan medium was formulated to improve microbial recovery, particularly for fastidious microorganisms and for microorganisms causing sepsis in patients receiving antimicrobial therapy. in a controlled clinical evaluation performed at four university-affiliated hospitals, fan anaerobic bottles were compared with standard anaerobic bottles for yield, speed of detection of microbial growth, and detection of septic episodes. a total of 10,431 blood culture sets were received; both anaerobic bottles of ... | 1995 | 7494013 |
| identification of candida species by pcr and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal dna. | the pcr was used to amplify a targeted region of the ribosomal dna from 84 candida isolates. unique product sizes were obtained for candida guilliermondii, candida (torulopsis) glabrata, and candida pseudotropicalis. isolates of candida albicans, candida tropicalis, candida stellatoidea, candida parapsilosis, and candida krusei could be identified following restriction digestion of the pcr products. | 1995 | 7494052 |
| in vitro antifungal and fungicidal spectra of a new pradimicin derivative, bms-181184. | a new pradimicin derivative, bms-181184, was compared with amphotericin b and fluconazole against 249 strains from 35 fungal species to determine its antifungal spectrum. antifungal testing was performed by the broth macrodilution reference method recommended by the national committee for clinical laboratory standards (document m27-p, 1992). bms-181184 mics for 97% of the 167 strains of candida spp., cryptococcus neoformans, torulopsis glabrata, and rhodotorula spp. tested were < or = 8 microgra ... | 1995 | 7726485 |
| importance of candida species other than c. albicans as pathogens in oncology patients. | a number of surveys have documented increased rates of candida infection over the past several decades. in this assessment of the frequency and distribution of non-albicans candida species among patients with cancer, 37 reports that were published between 1952 and 1992 and that described 1,591 cases of systemic candida infection were reviewed. species other than candida albicans accounted for 46% of all systemic candida infections in patients with cancer; specifically, candida tropicalis account ... | 1995 | 7727637 |
| a prospective study of microorganisms in urine and bladder biopsies from interstitial cystitis patients and controls. | interstitial cystitis (ic) is a chronic inflammatory condition of the bladder of unknown etiology. we tested the hypothesis that a microorganism would be found at higher prevalence in urine or bladder tissue from women with ic than from control women. | 1995 | 7855970 |
| penetration and damage of endothelial cells by candida albicans. | the mechanisms of phagocytosis of candida albicans by human vascular endothelial cells and subsequent endothelial cell injury were examined in vitro. both live and killed c. albicans cells were phagocytized by endothelial cells. this organism specifically induced endothelial cell phagocytosis because neither candida tropicalis nor torulopsis glabrata was ingested. endothelial cell microfilaments polymerized around c. albicans as the organisms were phagocytized. cytochalasin d inhibited this poly ... | 1995 | 7868270 |
| candida glabrata, candida krusei, non-albicans candida spp., and other fungal organisms in a sixty-bed national cancer center in 1989-1993: no association with the use of fluconazole. | during the 5-year period 1989-1993, the incidence of candida krusei, and other non-albicans candida spp., was analyzed in a 60-bed cancer department. the frequency of c. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in acute leukemia in 1991, the incidence of c. krusei was 12.7%. after 3 years of using this drug in therapy and prophylaxis, the incidence of c. krusei in 1993 was 14.8%, what was lower ... | 1995 | 7875020 |
| comparison of etest and national committee for clinical laboratory standards broth macrodilution method for azole antifungal susceptibility testing. | the use of etest strips for antimicrobial susceptibility testing is a new and promising method with broad applications in microbiology. since these strips contain a predefined continuous gradient of a drug, it is possible to obtain a reproducible, quantitative mic reading. we performed a prospective and double-blinded study to compare the etest and national committee for clinical laboratory standards (villanova, pa.) broth macrodilution methods for determining the mics of fluconazole, itraconazo ... | 1995 | 7751353 |
| epithelial adhesion in yeast species: correlation with surface expression of the integrin analog. | epithelial adhesion and expression of the integrin analog, a putative candidal adhesion, were correlated for 33 clinical and laboratory isolates of candida albicans, other candida species, and saccharomyces cerevisiae. on flow cytometry with saturating concentrations of the monoclonal antibody okm1, surface fluorescence was highest for c. albicans at 67.8% +/- 1.7% and significantly reduced for candida tropicalis (32.0% +/- 2.6%), candida parapsilosis (18.3% +/- 2.4%), candida glabrata (3.3% +/- ... | 1995 | 7769314 |
| torulopsis glabrata vaginitis. | to study the sociodemographic risk factors and clinical features of torulopsis glabrata vaginal infection. | 1995 | 7770272 |
| tuboovarian abscess associated with candida glabrata in a woman with an intrauterine device. a case report. | candidal infection has been associated extensively with serious infections. its role in genital tract infections has consisted largely of vulvovaginitis, with serious upper genital tract infection a rarity. a 47-year-old woman with an intrauterine device had candida glabrata in a large tuboovarian abscess and recovered only after removal of the abscess and treatment with amphotericin b. | 1995 | 7776309 |
| in vitro activity of d0870 compared with those of other azoles against fluconazole-resistant candida spp. | we compared the in vitro activity of a new triazole, d0870, with those of fluconazole, itraconazole, and ketoconazole against 41 clinical isolates of fluconazole-resistant candida belonging to nine different species. the 50% inhibitory concentrations (ic50s) were determined by a microdilution method with morpholinopropanesulfonic acid (mops)-buffered rpmi medium and an inoculum of approximately 10(4) yeasts per ml. after incubation for 48 h at 37 degrees c the optical density at 550 nm was measu ... | 1995 | 7785986 |
| microtitration plate enzyme immunoassay to detect pcr-amplified dna from candida species in blood. | we developed a microtitration plate enzyme immunoassay to detect pcr-amplified dna from candida species. nucleotide sequences derived from the internal transcribed spacer (its) region of fungal rdna were used to develop species-specific oligonucleotide probes for candida albicans, c. tropicalis, c. parapsilosis, and c. krusei. no cross-hybridization was detected with any other fungal, bacterial, or human dnas tested. in contrast, a c. (torulopsis) glabrata probe cross-reacted with saccharomyces ... | 1995 | 7790469 |
| fungemia in children infected with the human immunodeficiency virus: new epidemiologic patterns, emerging pathogens, and improved outcome with antifungal therapy. | we characterized 27 episodes of fungemia in 22 children infected with the human immunodeficiency virus (hiv). fungemia in these patients presented as a community-acquired infection in the setting of outpatient total parenteral nutrition or intravenous antibiotic therapy through a chronically indwelling central venous catheter (cvc). fungemia developed only in patients with cvcs (p < .001). non-albicans candida species, torulopsis glabrata, rhodotorula rubra, and bipolaris spicifera constituted 5 ... | 1995 | 7795092 |
| differences in oxidant release by human polymorphonuclear leukocytes produced by stimulation with different phases of coccidioides immitis. | human polymorphonuclear leukocytes (pmnl) inhibit growth of arthroconidia and young spherules but not mature spherules of coccidioides immitis. to evaluate these differences, oxidants were measured when pmnl were exposed to c. immitis or other particulate stimuli. concentrations of arthroconidia, young spherules, mature spherules, and candida glabrata were adjusted to result in equivalent superoxide release. hydrogen peroxide and hypochlorous acid were stimulated by arthroconidia or young spheru ... | 1995 | 7797911 |
| a purine permease in candida glabrata. | competition experiments revealed that adenine and guanine were transported by a purine permease in both candida glabrata 4 and a c. glabrata 4 cytosine permease negative mutant. the c. glabrata 4 cytosine permease negative mutant was isolated using 5-fluorocytosine selection. this mutant no longer transported cytosine, but transported adenine and guanine. a transport system for hypoxanthine was not detected. hence, in addition to the cytosine permease, a purine permease exists in c. glabrata. th ... | 1995 | 7896084 |
| in vitro antifungal activity of polyporaceae against yeasts and dermatophytes. | the antifungal activity of 38 polyporaceae sensu lato against yeasts and dermatophytes was tested in vitro by the agar dilution method. strains were typed organisms and clinical isolates. in this first report, pycnoporellus fulgens (fr.) donk was found to be the most active species against pathological fungi and showed broad-spectrum antifungal activity against yeasts (candida albicans, candida glabrata) and dermatophytes (trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, micr ... | 1995 | 8559195 |
| dna amplification for the in vitro detection of candida albicans in head and neck squamous cell carcinomas. | dna was extracted from whole cells of candida albicans and digested with hindiii restriction enzyme. after electrophoresis in a segment of the lane containing between 800 and 1200 base pairs (bp) of dna fragments, a 1.1-kilobase (kb) fragment was found that hybridizes to biopsied tumor cells from head and neck squamous cell carcinomas (scc). from the nucleotide sequence of the putative gene locus, primers were synthesized for use in a polymerase chain reaction (pcr) with dna extracted from 18 sc ... | 1995 | 8562037 |
| torulopsis glabrata: azole susceptibilities by microdilution colorimetric and macrodilution broth assays. | fluconazole and itraconazole mics were determined by both the standard macrodilution method of the national committee for clinical laboratory standards and a colorimetric broth microdilution method for 140 isolates of torulopsis (candida) glabrata obtained over a 15-year period. using the method of the national committee for clinical laboratory standards the mics at which 90% of isolates are inhibited (mic50) for all isolates were 32 and 1.6 micrograms/ml for fluconazole and itraconazole, respec ... | 1995 | 8567892 |
| comparative evaluation of macrodilution and alamar colorimetric microdilution broth methods for antifungal susceptibility testing of yeast isolates. | a comparative evaluation of the macrodilution method and the alamar colorimetric method for the susceptibility testing of amphotericin b, fluconazole, and flucytosine was conducted with 134 pathogenic yeasts. the clinical isolates included 28 candida albicans, 17 candida tropicalis, 15 candida parapsilosis, 12 candida krusei, 10 candida lusitaniae, 9 candida guilliermondii, 18 torulopsis glabrata, and 25 cryptococcus neoformans isolates. the macrodilution method was performed and interpreted acc ... | 1995 | 8567901 |
| molecular probes for diagnosis of fungal infections. | we have developed 21 specific nucleic acid probes which target the large subunit rrna genes from aspergillus flavus, aspergillus fumigatus, aspergillus glaucus, aspergillus niger, aspergillus terreus, blastomyces dermatitidis, candida albicans, candida (torulopsis) glabrata, candida guilliermondii, candida kefyr, candida krusei, candida lusitaniae, candida parapsilosis, candida tropicalis, coccidioides immitis, cryptococcus neoformans var. gattii, cryptococcus neoformans var. neoformans, filobas ... | 1995 | 8576345 |
| use of chromagar candida medium for isolation of yeasts from dental samples. | a new differential medium, chromagar candida, for the isolation of clinically important yeasts was investigated to determine its usefulness in facilitating the study of oral yeasts. the recovery of yeasts on the medium was not significantly different from the recovery on sabouraud dextrose agar. the identities of 450 green colonies on chromagar candida, presumptively identified as candida albicans on the basis of the manufacturer's instructions, were confirmed by testing for beta-n-acetylgalacto ... | 1995 | 8576366 |
| [rational use of antimycotics against yeast infections]. | in clinical medicine mere colonization with yeasts is often hardly to be discriminated from true infection. thus, a clear-cut separation of preventive from therapeutic use of antimycotics is not possible in practical medicine. the problem is that on the one hand one has no exact diagnosis of yeast infection, but on the other hand best therapeutic results are obtained when the drugs are given as early as possible. in comparison to the huge number of antibacterial compounds, the members of antimic ... | 1995 | 8582736 |
| parotitis due to torulopsis glabrata. | 1995 | 8589177 | |
| deletion of the candida glabrata erg3 and erg11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility. | we have cloned and sequenced the structural genes encoding the delta 5,6 sterol desaturase (erg3 gene) and the 14 alpha-methyl sterol demethylase (erg11 gene) from candida glabrata l5 (leu2). single and double mutants of these genes were created by gene deletion. the phenotypes of these mutants, including sterol profiles, aerobic viabilities, antifungal susceptibilities, and generation times, were studied. strain l5d (erg3 delta::leu2) accumulated mainly ergosta-7,22-dien-3 beta-ol, was aerobica ... | 1995 | 8593007 |
| in vitro activity of clotrimazole for candida strains isolated from recent patient samples. | minimum inhibitory concentrations (mics) of clotrimazole (cas 23593-75-1, bay 5097, clo) were determined for 142 clinical candida isolates obtained between 1992 and 1994, including the species candida albicans (96 strains), candida glabrata (12 strains), candida krusei (12 strains), and candida tropicalis (12 strains). for some of the candida isolates of all four species, the mics of amphotericin b and fluconazole were also determined. no mics of clo of > 4 micrograms/ml were found for all four ... | 1995 | 8595097 |
| effect of saliva composition on growth of candida albicans and torulopsis glabrata. | candida albicans and torulopsis glabrata are the most prevalent yeasts in humans. the majority harbor c. albicans in the oral cavity, but only a few develop oral candidiasis. we have sought a possible relationship between indigenous salivary constituents, including antimicrobial and nutritive factors, and the growth rate and/or viability of inoculated fungi in glucose-supplemented sterilized saliva. stimulated whole saliva was collected from 30 healthy donors. saliva samples were sterilized, sup ... | 1995 | 8602336 |
| cloning of the candida glabrata trp1 and his3 genes, and construction of their disruptant strains by sequential integrative transformation. | the candida glabrata (cg) trp1 and his3 genes have been isolated by complementation of the saccharomyces cerevisiae (sc) trp1 and his3 mutants, respectively. cg trp1 encodes a polypeptide of 217 amino acids (aa), whose aa sequence is 58% identical to that of sc trp1. cg his3 encodes a polypeptide of 210 aa, whose aa sequence is 73% identical to that of the sc his3. both cg trp1 and his3 were disrupted by sequential integrative transformation where the sc ura3 was used as a selection marker for t ... | 1995 | 8522176 |
| candida glabrata epididymo-orchitis: an unusual infection rapidly cured with surgical and antifungal treatment. | we report a case of epididymo-orchitis and secondary fungaemia caused by candida (previously torulopsis) glabrata in an 83-year-old male patient who had diabetes mellitus, urinary outflow obstruction and previous bladder malignancy. we believe this to be a previously unreported site of infection with c. glabrata and we describe its rapid and successful treatment with combination anti-fungal therapy. | 1995 | 8522840 |
| catheter-related intracardiac thrombosis: a rare complication of candida glabrata sepsis. | a 58-year-old patient suffered from persistent candida glabrata fungaemia. transoesophageal echocardiography detected a central venous catheter-related intracardiac thrombosis. cardiotomy permitted the removal of the catheter and its adherent clot. candida glabrata was cultured from the thrombus. | 1995 | 8533535 |
| [intestinal obstruction and sepsis caused by torulopsis glabrata]. | a 27-year-old woman previously diagnosed of aplastic anemia secondary to treatment with gold salts for rheumatoid arthritis, presented with an episode of intestinal occlusion with acute renal failure. a ct scan revealed dilated intestinal loops, thickening of the ileum wall without cecal involvement, and multiple punctuate lesions (micro-abcesses) of liver, spleen and kidneys. at laparotomy, one meter of proximal jejunum was resected. the cultures of jejunal biopsy specimens yielded torulopsis g ... | 1995 | 8534539 |
| antifungal susceptibility testing of yeasts: evaluation of technical variables for test automation. | the technical parameters for antifungal susceptibility testing with candida species were reexamined to determine the optimal conditions for testing with semiautomated preparations of broth microdilution cultures, automated spectrophotometric readings of the cultures, and dose-response and endpoint determinations by means of a computer spreadsheet. tests were based on proposed standard method m27p of the national committee for clinical laboratory standards for antifungal agents. rpmi 1640 broth w ... | 1995 | 8540715 |
| improved detection of medically important fungi by immunoperoxidase staining with polyclonal antibodies. | this study was performed to identify pathological fungi of eight species [aspergillus fumigatus, candida albicans, torulopsis (candida) glabrata, cryptococcus neoformans, fusarium anthophilum, rhizopus oryzae, sporothrix schenckii and trichosporon beigelii] in formalin-fixed, paraffin-embedded tissue sections by indirect immunoperoxidase staining. mature albino rabbits were immunized with formalin-killed organisms. antibodies were prepared by precipitation. immunoperoxidase staining was applied ... | 1995 | 8548126 |
| analysis of copper-induced metallothionein expression using autonomously replicating plasmids in candida glabrata. | candida glabrata strains and a stable plasmid were developed that were suitable for analysis of copper-inducible expression from promoters of the three metallothionein (mt) genes. the two homologous mtii genes, mtiia and mtiib, encode the same polypeptide but are differentially induced by copper salts. mtiib is more highly inducible than mtiia and cells harboring a single mtiib exhibit a greater resistance to copper salts compared to cells harboring a single mtiia. the differential copper induci ... | 1995 | 8750238 |
| itraconazole susceptibilities of fluconazole susceptible and resistant isolates of five candida species. | the in-vitro susceptibilities of 1380 isolates of five candida species were determined in order to establish whether isolates resistant to fluconazole were cross-resistant to itraconazole. ic50 values were determined by a broth microdilution method. 690 candida albicans isolates, seven candida glabrata isolates, seven candida krusei isolates, 120 candida parapsilosis isolates and 37 candida tropicalis isolates were susceptible to both fluconazole (ic50 < or = 32 mg/l) and itraconazole (ic50 < or ... | 1995 | 8626259 |
| oral fluconazole versus amphotericin b bladder irrigation for treatment of candidal funguria. | a randomized trial was conducted to compare amphotericin b bladder irrigation (ambbi) with oral fluconazole in terms of efficacy and safety in the treatment of candidal funguria. fifty-three patients with two consecutive positive funal cultures of urine were randomized to undergo ambbi (50 mg/l over 24 hours or 50 mg/l for 7 days) or to receive fluconazole (200 mg/d for 7 days). urinary catheters were changed upon entry into the study and following therapy. blood and urine specimens were obtaine ... | 1995 | 8645847 |
| torulopsis glabrata-infected pancreatic pseudocysts. diagnosis and treatment. | torulopsis glabrata, a fungus commensal with the human gastrointestinal tract, so far has not been recognized as a cause of pancreatic sepsis. we report the cases of two patients with pancreatic pseudocysts that became infected with t. glabrata. a 20-year-old woman 6 weeks postpartum had acute gallstone pancreatitis complicated by pseudocyst formation and pancreatic sepsis. pseudocyst fluid obtained at cystogastrostomy showed a pure culture of t. glabrata. a 52-year-old man with multiple medical ... | 1995 | 8648059 |