Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| mechanisms of action of immunopotentiating agents in cancer therapy. | 1977 | 329658 | |
| penetration of cells into millipore diffusion chambers. | 1977 | 330180 | |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | 1977 | 330190 | |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | 1977 | 330869 | |
| management of metastatic breast cancer. | 1977 | 330978 | |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | 1977 | 333124 | |
| [porphyrinsynthesis by propionibacterium acnes (author's transl)]. | strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ... | 1977 | 334087 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| immunotherapy in the treatment of cancer. | this article is a review of immunotherapy in the treatment of cancer incorporating the history of immunotherapy in the nineteenth and twentieth centuries, assessment of the techniques currently in use and of possible future developments. although immunotherapy is not established as a therapeutic technique, evidence suggests that the immune response does influence the development of neoplastic cells. a better understanding of the immune response and its control may lead to the production of effic ... | 1977 | 337486 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy. | 1977 | 305373 | |
| a role for t lymphocytes in the antitumour action of systemic c. parvum. | the frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (fsa) was not influenced by systemic administration of c. parvum (day + 3) except when doses less than the td50 were injected. then the number of takes was increased. the tumour normally grows progressively however regression was frequent in intact mice treated with c. parvum. tumour regression did not occur in t cell-depleted mice treated in the same way. splenic t cell-enriched populations of ce ... | 1977 | 305374 |
| possible mechanisms in the anti-tumour activity of c. parvum. | normal murine peritoneal macrophages exhibited anti-tumour cytotoxicity following simultaneous incubation with c. parvum and lymphoid cells from c. parvum-treated mice. both t- and b-lymphocytes appear to be involved in this macrophage activation which is mediated by a soluble factor(s) released by immune lymphoid cells in response to the specific immunising strain of c. parvum. cells capable of macrophage activation do not appear until 6 days following systemic c. parvum administration despite ... | 1977 | 305375 |
| effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits. | sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ... | 1977 | 401511 |
| a special report: four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth. | a 4-year study of a boy with combined immune deficiency is presented, and the impact of this disease on various aspects of his growth and development is examined. there is no evidence of immune deficiency in either parent or in the genetic background on the maternal side. three children of a brother of the mother's father may have had immune deficiencies but two have grown to be teenagers with no problems. another died. at autopsy, however, lymph nodes appeared normal. the deceased older brother ... | 1977 | 401538 |
| effect of bacterial products on inflammatory reactions in the dental pulp. | culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ... | 1977 | 402688 |
| antitumor activity of a brucella abortus preparation. | mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. intraperitoneal injection of a nonviable, aqueous... ether-extracted brucella abortus preparation (bru-pel) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. bru-pel was not effective if injected after ascites was grossly apparent. bru-pel was significantly more active than a corynebacterium parvum prepa ... | 1977 | 404249 |
| bacteremia after upper gastrointestinal endoscopy. | during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ... | 1977 | 404974 |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| bacteraemia in asymptomatic human subjects. | 1977 | 405961 | |
| [radioprotection conferred by corynebacterium parvum against the lethality caused by x irradiation at sublethal and lethal doses in the mouse]. | intraperitoneal injection of corynebacterium parvum (c. parvum) into balb/c mice produces a protection against toxicity or lethality provoked by ionizing radiation (750 r and 950 r). survivals reaching nearly 90 days have been recorded. | 1977 | 406088 |
| ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy. | appreciating the past reports of effectiveness for various therapeutic modalities in ovarian cancer, the gynecologic oncology group activated eight protocols. three involved epithelial lesions with randomized multimodality trials alone or in combination. the other protocols were devoted to registration of rare tumor case reports. conclusions are still difficult to reach due to inconsistencies in pathologic diagnoses and deficiencies in radiation therapy, chemotherapy and surgery inherent in the ... | 1977 | 406985 |
| antitumor activity of propionibacterium acnes (corynebacterium parvum) and isolated cytoplasmic fractions. | the tumor-inhibitory effect of an intralesional injection of propionibacterium acnes was of limited duration ("finite"). our model was the dba/2 syngeneic mouse injected with p815 mastocytoma cells (5 x 10(5)) into each rear footpad; only the left was treated, leaving the right as a "pseudometastasis." the finite effect occurred at approximately 21 days after the first treatment. subsequent i.p. treatments with p. acnes did not alter this effect, although they increased mean survival time. with ... | 1977 | 409491 |
| reticulostimulating properties of killed vaccines of anaerobic coryneforms and other organisms. | vaccines prepared from 115 strains of anaerobic coryneforms and other organisms were tested in mice for their reticulostimulating ability as judged by the degree of spleen hypertrophy produced after ip injection. almost all vaccines caused a statistically significant increase in spleen weight, but the ability to produce spleen ratios (test mean wt:control mean wt) of 4 or more was confined to propionibacterium acnes and p. avidum strains. p. acnes, type ii, gave high spleen ratios more frequentl ... | 1977 | 411938 |
| effect of the combination of corynebacterium parvum and levamisole on murine tumors. | 1977 | 413718 | |
| organ distribution of corynebacterium parvum labeled with iodine-125. | administration of iv, ip, single sc, multiple sc, and footpad injections of [125i]corynebacterium parvum in mice revealed different patterns of radioactive vaccine distribution in various organs. high deposition and retention were found in the liver, spleen, and gastrointestinal tract and less in the lungs, kidneys, thymus, and bone marrow. control animals given 125i showed very rapid clearance of the isotope and no retention in the organs. the pattern of distribution of [125i]c. parvum could be ... | 1977 | 833877 |
| systemic therapy for metastatic breast cancer. | the data reviewed in this conference suggest that initial therapeutic decisions for patients with metastic breast cancer be based on the presence or absence of an estrogen receptor in the tumor. patients with estrogen receptor in their original primary breast cancer or in a subsequent metastitic lesion are candidates for hormonal manipulation, whereas patients lacking estrogen receptor in their tumor are treated for their metastic disease with nonhormonal chemotherapy. nonhormonal therapy usuall ... | 1977 | 835932 |
| susceptibility of propionibacterium acnes to seventeen antibiotics. | the in vitro susceptibility of 96 isolates of propionibacterium acnes to 17 antibiotics was determined by utilizing an agar dilution technique. with the exception of the aminoglycosides, these organisms are susceptible to virtually all of the commonly used antimicrobial agents. | 1977 | 836012 |
| isolation and identification of fecal bacteria from adult swine. | an examination of the fecal microflora of adult swine was made with regard to the efficiency of several roll tube media in enumeration and recovery of anaerobes, the effects of medium constituents on recovery, and the isolation and identification of the predominant kinds of bacteria. total number of organisms by microscopic bacterial counts varied among fecal samples from 4.48 x 10(10) to 7.40 x 10(10) bacteria/g (wet weight). comparison of different nonselective roll tube media indicated that a ... | 1977 | 836025 |
| intravenous corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer. | this is a prelimianry report of an effort to treat women with advanced (stage iii and iv) ovarian cancer who had progressive disease in spite of previous surgery, chemotherapy and/or radiation by a program of reductive surgery, intensive immune stimulation and combination chemotherapy. an initial laparotomy was done where possible to reduce tumor burden, and then all patients were given intravenous corynebacterium parvum (c.p.) in escalating doses over a 10- to 14-day period. cyclic chemotherapy ... | 1977 | 837334 |
| in vitro and in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages. | in virto exposure of murine lymphoma cells to adriamycin and daunomycin (dm) for 24 hr resulted in comparable cytotoxicity as assessed by viable cell counts and inhibition of dna synthesis. the spontaneous dna synthesis of spleen lymphocytes in vitro was also equally affected by the two agents. however, when the in vitro effects of the two drugs on macrophage monolayers were investigated, dm was found to be at least four times more toxic than am. in vivo-administered dm was more suppressive than ... | 1977 | 837378 |
| chemoattractant properties of corynebacterium parvum and pyran copolymer for human monocytes and neutrophils. | both pyran copolymer and the burroughs-wellcome vaccine of corynebacterium parvum were able to elicit a migratory response by human neutrophils or monocytes when incubated with serum. however, in the absence of serum, neither agent elicited such a response. the generation of the chemotactic factor by pyran was dependent on heat-labile components in the serum, while suggested involvement of the complement sequence. conversely, the migratory response of c. parvum in heated serum was equivalent to ... | 1977 | 839571 |
| the influence of nonspecific immunotherapy on the course of murine melanoma. | bcg, corynebacterium parvum, vitamin a, and levamisole were continuously administered to c57 bl/6 mice bearing b16 melanoma prior to, with following tumor implantation as well as before and coincident with surgical excision of the implanted tumor. only the group given levamisole prophylactically for 8 weeks before tumor inplantation showed a significant difference from control mice but a tenfold increase in dosage in this drug did not exert a comparable effect. | 1977 | 839793 |
| corynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma. | weekly i.p. injections of killed corynebacterium parvum and of cyclophosphamide (given on different days) strongly inhibited growth of a transplantable murine mammary adenocarcinoma. a significant portion (40 to 80%) of animals could be made tumor free by means of combined therapy. no tumor-free survivors were obtained with c. parvum alone, and tumor-free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. no evidence of tumor re ... | 1977 | 844041 |
| [susceptibility to thiamphenicol and chloramphenicol of anaerobic bacteria (author's transl)]. | the in vitro susceptibility to thiamphenicol and chloramphenicol of 272 anaerobes, most of which were recent clinical isolated, was determined by broth dilution tests, with chloramphenicol, 133 anaerobic gram-negative non-sporing rods (48 bacteroides fragilis, 13 b. thetaiotaomicron, 14 b. oralis, 16 sphaerophorus varius etc.) had mic values of 0.03 through 16 microng/ml. very similar results (mic, 0.06-16 microng/ml) were obtained with thiamphenicol. in concentrations of 4 microng/ml or less ch ... | 1977 | 848218 |
| anaerobic bacteria in otitis media. | anaerobic bacteria, peptostrepotococcus intermedius and propionibacterium acnes, were found in mixed culture specimens from four to ten tested cases of chronic secretory otitis media. these anaerobic bacteria were in a mixed infection flora with aerobic bacteria most often staphylococcus epidermidis and cornybacterium sp. which do not fit any established species. the findings of anaerobic bacteria in otitis media is consistent with the sporadic report of the involvement of anaerobic bacteria in ... | 1977 | 848830 |
| increased spreading of macrophages from mice treated with interferon inducers. | 1977 | 849607 | |
| radiolabelling of corynebacterium parvum and its distribution in mice. | corynebacterium parvum was labelled by growing live bacteria in the presence of [3h]thymidine. the bacteria were killed by formalin, washed thoroughly and resuspended at a concentration of 7 mg dry weight/ml. an activity of 1-6 x 10(5) ct/min/0-1 ml was obtained. the biological properties (inhibition of tumour growth and hepatosplenomegaly) of the labelled c. parvum were compared with those of commercially available vaccine, and were found to be similar. labelled c. parvum was injected i.v., i.p ... | 1977 | 851511 |
| immunology of lung cancer. | 1977 | 852345 | |
| susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methods. | a total of 114 strains of anaerobic bacteria were examined for their susceptibility to metronidazole, ornidazole, and tinidazole by measuring the minimum inhibitory concentration (mic) and minimum bactericidal concentration in different media. all strains, with the exception of the isolates of propionibacterium acnes, were inhibited by 3.1 mug each and killed by 6.3 mug each of all three nitroimidazole compounds per ml. no significant differences in mic values were found among metronidazole, orn ... | 1977 | 856015 |
| effects of c. parvum on growth and induction of intracerebral tumours in mice. | an investigation was made into the effect of corynebacterium parvum therapy on cerebral tumours in mice. i.v. c. parvum caused a slight but significant increase in the survival of balb/c mice injected intracerebrally (i.c.) with not more than 50 meth a cells. c. parvum was most effective if given on the same day or 5 days after tumour. if this interval was increased there was no effect. multiple i.v. injections were no more effective than a single dose. i.v. c. parvum had no influence on the sur ... | 1977 | 857825 |
| serological changes associated with c. parvum treatment in nude mice. | 1977 | 861151 | |
| effect of c. parvum and active specific immunotherapy on intracerebral transplants of a murine fibrosarcoma. | 1977 | 861152 | |
| combined treatment with anaerobic corynebacterium liquefaciens and chemotherapeutics against solid tumor in mice. | the combined effect of anticancer agents (mitomycin-c, cyclophosphamide, or 5-fluorouracil) and anaerobic corynebacterium liquefaciens on subcutaneously induced solid ehrlich carcinoma in mice was examined. mitomycin-c and cyclophosphamide were given intraperitoneally on day 7 after inoculation of tumor cells. 5-fluorouracil was administered intraperitoneally for 7 consecutive days from day 9 to 15. c. liquefaciens was given in two ways, intraperitoneally and intratumorally. its injections were ... | 1977 | 863171 |
| an analysis of the factors allowing promotion (rather than inhibition) of tumour growth by corynebacterium parvum. | the following factors were found to determine whether c. parvum (cp) treatment promoted rather than inhibited the growth of methylcholanthrene-induced fibrosarcoma cells injected into cba mice. (1) the dose of tumour cells. promotion occurred only with low doses, around the td50. (2) the route of injection of cp. greater promotion was caused by intravenous (iv) than by subcutaneous (sc) administration. addition of irradiated tumour cells to sc cp resulted in tumour inhibition. (3) the dose of cp ... | 1977 | 863546 |
| effect of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole on macrophage random migration, chemotaxis, and pinocytosis. | three parameters of macrophage function: random migration, chemotaxis, and pinocytosis, were studied in the guinea pig after administration of corynebacterium parvum, methanol-extraction residue of bcg, and levamisole (lms), a synthetic anthelmintic. macrophage migration studies were performed with a modified boyden chamber. pinocytosis was assessed by the uptake of colloidal 198au. after ip administration, each of the three immunostimulators induced an increase in macrophage chemotactic respons ... | 1977 | 864753 |
| the distribution and persistence in vivo of corynebacterium parvum in relation to its antitumor activity. | killed corynebacterium parvum was labeled with fluorescein isothiocyanate or 125i, and both preparations were shown to retain lymphoreticular stimulatory and antitumor activity. large amounts of c. parvum injected i.v. were found in the liver, spleen, and lungs with less in bone marrow and lymph nodes. apart from a rapid loss from the lungs within 24 hr, the persistence of killed c. parvum was striking, and some intact bacteria were still detectable in the liver and spleen at 15 days. (by contra ... | 1977 | 870181 |
| antibody to corynebacterium parvum in normal human and animal sera. | using a microtiter bacterial agglutination test, we have estimated antibodies to corynebacterium parvum in "normal" human and "normal" and immune animal sera. widely differing levels of c. parvum antibodies were found in the normal human sera. the median titer for all 310 human sera was 1:128, whereas that for the 1- to 17-year and 18- to 50-year subgroups was 1:64 and 1:512, respectively. antibody titers in the various animal species were generally much lower. | 1977 | 870426 |
| comparative effect of anaerobic coryneforms on a murine melanoma. | ten strains of anaerobic corynebacteria were compared in their effect on survival of c57bl/6 mice, bearing subcutaneously inoculated b16 melanomas. the corynebacterial suspensions were injected intralesionally twice weekly for five injections. significant permanent tumor regression was not obtained. significant prolongation of survival was observed in mice treated with seven of the corynebacterial strains. | 1977 | 872039 |
| cell-mediated immunity and serum blocking factors in cancer patients during chemotherapy and immunotherapy. | the leukocyte adherence inhibition test was used to monitor tumor-specific cell-mediated immunity in 15 patients who had a variety of malignant tumors and were undergoing chemotherapy alone or in combination with immunotherapy by corynebacterium parvum. a rapid and prolonged loss of cell-mediated immunity in blood leukocytes was observed after treatment in all but one of the patients studied. abolition of reactivity was due to the lack of production of the soluble lymphokine-like factor affectin ... | 1977 | 872076 |
| separation and characterization of epithelial cells from prostates and prostatic carcinomas: a review. | our investigation of normal, hyperplastic, and neoplastic prostatic tissue during the past 2 1/2 years has produced several findings which have been published or accepted for publication. (a) cells from hamster prostates with intense histochemically demonstrable acid phosphatase activity (hdap) after fixation with formaldehyde which we believe to be epithelial cells can be obtained in 97.2% +/- 0.8% purity by velocity sedimentation in a previously described isokinetic density gradient; (b) simil ... | 1977 | 872127 |
| immunological response in patients receiving corynebacterium parvum therapy. | 1977 | 872468 | |
| corynebacterium parvum-induced radiosensitivity and cycling changes of hematopoietic spleen colony-forming units. | ten days after total-body irradiation with 550 rads of b0co, spleen colonies were observed in adult c57bl mice. a change in radiosensitivity induced by corynebacterium parvum, as measured by increased numbers of colony-forming units that survived the 550 rads, began shortly after c. parvum stimulation and extended for at least 7 days before irradiation. c. parvum given 4-24 hours before, followed by high specific activity [3h]thymidine (hsatt) 1 hour before total-body irradiation greatly reduced ... | 1977 | 875052 |
| propionibacterium acnes meningitis in a previously normal adult. | a 25-year-old man was previously healthy until he contracted acute propionibacterium acnes meningitis. comparison with previous reports of de novo diphtheroid meningitis suggests that this entity can appear with features that are not characteristic of acute bacterial meningitis, including (1) stroke-like syndromes, (2) an afebrile course, and (3) a cerebrospinal fluid with a mononuclear pleocytosis and normal glucose level. the appropriate choice and dosage of antimicrobial agent must be guided ... | 1977 | 879934 |
| modulation of host immune response against the l2c guinea pig leukemia. | 1977 | 885264 | |
| host immunological mechanisms in the resistance of mice to leptospiral infections. | several serovars of leptospira virulent for hamsters and guinea pigs caused acute lethal leptospirosis in mice immunosuppressed with cyclophosphamide. neither bcg vaccine nor corynebacterium parvum suspension influenced the course of leptospiral infection in either immunosuppressed or normal balb/c mice. nude athymic mice produced anti-leptospiral antibody and were therefore resistant to infection with leptospires. nude mice were made susceptible with cyclophosphamide but were immune if they had ... | 1977 | 885617 |
| an adenylate cyclase of brain reflects propensity for breast cancer in mice. | high propensity for breast cancer in mice was associated with low dopamine-stimulated adenylate cyclase activity in the brain, low spontaneous motorization, and low motor responses to injections of the catecholamine precursor, l-dopa. | 1977 | 887942 |
| intravascular coagulation resulting from intravenous injection of c. parvum in mice. | in mice, i.v. c. parvum induces intravascular coagulation. this is a prolonged reaction lasting up to 7 days. it results in thrombosis in hepatic vessels with consequent hepatic necrosis, and thrombosis in pulmonary and splenic vessels. this may be important in the assessment of the tumour-inhibitory activity of c. parvum. | 1977 | 889682 |
| mechanism of the anti-tumour effect of glucans and fructosans: a comparison with c. parvum. | the anti-tumour activity induced by glucans (lentinan, yeast cell walls, pseudonigeran, dextran, deae-dextran and dextran sulphate) and fructosans (levan and carboxymethyl-levan) was compared with the activity of c. parvum. the following effects on tumour systems in cba mice were assayed: (a) adjuvant activity on the immune response against tumour-specific transplantation antigens (tsta) with a methylcholanthrene-induced fibrosarcoma; (b) cytostatic activity of peritoneal macrophages against rad ... | 1977 | 889684 |
| comparative study of corynebacterium parvum and corynebacterium liquefaciens on antitumor activity against sarcoma-180. | corynebacterium parvum and corynebacterium liquefaciens were comparatively examined for their antitumor activity against sarcoma-180 in ddy mice. in the case of ascitic form, significant antitumor effect was observed when c. parvum was administered on days -4 and -2 or day -2. as for solid form, maximal effect was obtained when c. parvum was administered on day 0. on the other hand, c. liquefaciens exhibited maximal antitumor activity against sarcoma-180, both in ascitic and solid forms, when it ... | 1977 | 892298 |
| effect of immunomodulators on effector cells involved in antibody-dependent cellular cytotoxicity: brief communication. | the effect of four immunomodulators (bcg, corynebacterium parvum, pyran copolymer, and levamisole) on the cellular arm of antibody-dependent cellular cytotoxicity (adcc) was investigated in mice with 51cr-labeled chicken erythrocytes employed as targets. all these drugs, except levamisole, stimulated the effector cells of adcc in the spleen, but the kinetics of their effect differed. stimulation of the effector cells of adcc peaked on day 15 after injection of bcg and c. parvum and on day 7 afte ... | 1977 | 894742 |
| combined radiotherapy and corynebacterium parvum treatment of a murine fibrosarcoma. | a single dose of corynebacterium parvum (cp) at 70 microgram, 175 microgram or 350 microgram was effective in suppressing the growth of a subcutaneous fibrosarcoma and occasionally in inducing complete regression and in prolonging the survival time of c3h/hej tumor-bearing mice. a single exposure of x rays at 2,000 rads induced some complete regression, but a higher number of complete regressions was induced by combined x-ray and cp treatment. in the combined x-ray and cp treatment, cp given on ... | 1977 | 897175 |
| bacteriology of cholesteatoma: clinical significance. | 1977 | 898521 | |
| [effect of corynebacterium parvum on various viral infections in the mouse]. | 1977 | 900789 | |
| local control and disease-free survival after treatment of a squamous cell carcinoma by corynebacterium parvum and local irradiation. | 1977 | 908026 | |
| efficacy of corynebacterium parvum treatment of mice with sarcoma growing in normal or irradiated tissue. | 1977 | 908052 | |
| increase of phagocytic activity and new appearance of a c4b (guinea pig) recognizing capability in peritoneal macrophages from corynebacterium parvum and thioglycollate-stimulated mice. | activated mouse macrophages displayed enhanced phagocytic activity towards particles opsonized with igg antibody and homologous c3. in addition, they were able to recognize guinea pig c4b. it is concluded that activated macrophages develop phagocytically active receptors for heterologous c4b. | 1977 | 917013 |
| investigations on prostatic adenocarcinomas in rats. | metastatic prostate adenocarcinomas, derived from aging germfree wistar rats, have been propagated in rats and in tissue culture. a protocol has been developed and demonstrated for assay of treatments which retard or which accelerate the rate and extent of tumor growth and of metastasis in tumor-bearing rats. the pattern of spread has been retarded by cyclophosphamide, aspirin, indomethacin, and corynebacterium parvum. the spread pattern has been accelerated by oral administrations of sodium bar ... | 1977 | 917442 |
| effects of corynebacterium parvum on tumour metastases in mice. | 1977 | 922293 | |
| expression of a new cell surface antigen on activated murine macrophages. | a macrophage cell-surface antigen associated with pyran and corynebacterium parvum-activated macrophages and p388d1 cells but not detectable on normal or glycogen and thioglycollate-elicited murine macrophages has been described. the antigen was demonstrated both by complement-mediated cytotoxicity and immunofluorescence, using an appropriately absorbed rabbit antiserum to p388d1. this antiserum should enable the characterization of activated macrophage cell populations on an individual cell bas ... | 1977 | 925608 |
| a study on the characterization of corynebacterium acnes. | forty-nine strains of anaerobic gram-positive rods were used in a systematic study of their biochemical and physiological reactions and morphological characteristics and were also subjected to gas chromatographic analyses in an effort to classify them as strains of corynebacterium acnes (c. acnes). the strains were isolated both from lesions in acne vulgaris and from normal skin. according to their biochemical and physiological characters, these 49 strains were divided into six subgroups (subgro ... | 1977 | 15461349 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors. | 1978 | 413929 | |
| [immunotherapy of malignant diseases. a way towards the goal?]. | 1978 | 305530 | |
| induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. | 1978 | 307432 | |
| a role for t lymphocytes in tumour inhibition and enhancement caused by systemic administration of corynebacterium parvum. | 1978 | 308542 | |
| effect of corynebacterium parvum on human t-lymphocyte interferon production and t-lymphocyte proliferation in vitro. | 1978 | 309789 | |
| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice. | natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ... | 1978 | 342602 |
| antitumor activity of corynebacterium parvum. | 1978 | 343523 | |
| complement activation in acne vulgaris: in vitro studies with propionibacterium acnes and propionibacterium granulosum. | to better define the role of bacteria in inflammatory acne vulgaris, we have investigated the ability of four strains of propionibacterium acnes and three strains of propionibacterium granulosum to activate complement. complement activation was assayed by incubating normal human serum with varying concentrations of each strain and measuring residual total hemolytic complement activity. when serum was tested unaltered, p. acnes strains were approximately threefold more potent than an equal weight ... | 1978 | 153333 |
| acne: current concepts. | 1978 | 153517 | |
| adjuvant immunotherapy. | because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. for this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. chemotherapy is potent and systemic in its effects but kills tumor cells by first-order kinetics so the last cancer cell may not be eliminated. an agent is needed that can selectively attack and destroy small numbers of tumor ... | 1978 | 399764 |
| adjuvant intralesional and systemic corynebacterium parvum immunotherapy for surgically treated head and neck cancer. | 1978 | 401122 | |
| organ distribution of technetium-99m-labeled corynebacterium parvum in normal and tumor-bearing mice. | 1978 | 618580 | |
| correlation of antitumor chemoimmunotherapy with serum inhibition of tumor cell destruction. | the administration of cyclophosphamide and corynebacterium parvum in combination results in tumor growth inhibition greater than that resulting from the use of either agent alone. the precise mechanism(s) by which this chemoimmunotherapy combination results in a synergistic inhibiting effect is not known. the possibility was entertained that the tumor effect might be related to a greater decrease in serum-mediated interference with cellular cytotoxicity, i.e., "blocking" activity, by both agents ... | 1978 | 618581 |
| influence of immunotherapeutic agents on the progression of spontaneously arising, metastasizing rat mammary adenocarcinomas of varying immunogenicities. | 1978 | 618584 | |
| immune responses during administration of adriamycin and corynebacterium parvum. | 1978 | 618689 | |
| [immunological and immunotherapeutical aspects of cancer (author's transl)]. | 1978 | 619481 | |
| [finding of anaerobic bacteria in blood cultures]. | out of the blood cultures sent to the bacteriology laboratory of hospital del niño dif, during the period of one year, in 1.4% of samples, isolation of anaerobic bacteria was obtained. isolation was more frequent in infants under one year of age, but specially in newborns. the species most frequently found were propionibacterium acnes, bacteroides melaninogenicus and clostridium subterminale. the presence of this finding in blood cultures of infants is noted, but there is no purpose to establish ... | 1978 | 619923 |
| heterologous immunity between piroplasms and malaria parasites: the simultaneous elimination of plasmodium vinckei and babesia microti from the blood of doubly infected mice. | mice which have recovered from infections with the avirulent piroplasm babesia microti are also resistant to challenge with the virulent malaria parasite plasmodium vinckei. in mice infected with p. vinckei before the peak of the b. microti infection the numbers of malaria parasites in the blood increase until that peak and are then eliminated at the same time as the piroplasms. in mice infected with p. vinckei at or after the peak there is no apparent multiplication and the malaria parasites be ... | 1978 | 622306 |
| regional variations of cutaneous propionibacteria. | propionibacterium acnes, p. avidum, and p. granulosum were quantitatively measured in 50 young adults. the scalp, forehead, external auditory canal, alae nasi, anterior nares, groin, rectum, and antecubital and popliteal fossa were sampled. these represent various cutaneous microenvironments, differing in moisture, density of sweat, sebaceous glands, and extent of anaerobiosis. these studies show that the propionibacteria are ubiquitous on the skin, with p. acnes predominant in both prevalence a ... | 1978 | 623473 |
| treatment of malignant ascitic and pleural effusion with corynebacterium parvum. | six patients with malignant effusions, five from adenocarcinomas and one from a melanoma, were treated by intrapleural or intraperitoneal corynebacterium parvum. in each case there was a definite reduction in the effusions with a significant decrease in the number of malignant cells; in most cases the effusions stopped completely. although none of the patients lived for more than a year after treatment, they were undoubtedly more comfortable, as they no longer required frequent paracentesis. in ... | 1978 | 623981 |
| use of bacteriophage typing to distinguish propionibacterium acne types i and ii. | strains of serotypes i and ii of propionibacterium were compared for phage sensitivity. the two serotypes could be distinguished by using a typing set consisting of 16 bacteriophages at concentrations that demonstrated selective lysis of serotype i or ii bacterial strains. seven phage types were found; three were composed exclusively of serotype i, and four were exclusively composed of serotype ii organisms. generally, serotype i strains were more sensitive to phage lysis than were serotype ii s ... | 1978 | 624772 |
| antitumor activity of purified cell walls from corynebacterium parvum. | cell walls (cw), containing peptidoglycan and carbohydrate, were prepared from corynebacterium parvum and tested for lymphoreticular stimulation and antitumor effects in cba-t6t6 mice. cw did not induce splenomegaly. peritoneal macrophages became cytostatic to rl leukemia cells in vitro after ip injection of cw or of peptidoglycan but not of carbohydrate; however, on a dry-weight basis the activity was low (less than 10%) compared with that of c. parvum. tumor outgrowth was significantly suppres ... | 1978 | 625069 |
| immunotherapy of an established rat mammary adenocarcinoma (13762a) with intratumor injection of corynebacterium parvum. | we studied the effects of intratumor injection of corynebacterium parvum vaccine on the survival of 13762a tumor-bearing rats. vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. although 30 to 40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases ultimately killed one-fourth of the regressors. rats given 1500 microgram of c. parvum intratumorally at 7 days, with or without later ... | 1978 | 626972 |
| enhancement by corynebacterium parvum of the normal and tumor tissue response to hyperthermia. | the effect of corynebacterium parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5 degrees) was studied. animals were c3hf/sed mice from our defined flora mouse colony. the time at hyperthermia that achieved control of one-half of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. c. parvum, if given 3 to 32 days before hyperthermia, enhanced the reaction to local hyperthermia of normal tissue. no enhancement was observed if ... | 1978 | 626985 |
| natural cell-mediated cytotoxicity in rats. ii. in vivo augmentation of nk-cell activity. | natural cell-mediated cytotoxicity in rats as well as in mice has been shown to vary consistently with age, with peak levels detectable at 5-10 weeks. the levels of cell-mediated cytotoxicity against tumor cells could be augmented in strains of inbred rats with either high or low levels of natural reactivity, by ip injection of a variety of agents, including c. parvum, lcmv, krv, and poly i:c. the specificity of the augmented cytotoxicity appeared to be the same as the specificity of natural kil ... | 1978 | 627428 |