Publications

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studies on the relationship between the transforming activity and the integrity of dna as revealed by ultraviolet flow dichroism. 19654379648
optical activity and conformation of carbohydrates. i. optical rotatory dispersion studies on immunochemically reactive amino sugars and their glycosides, milk oligosaccharides, oligosaccharides of glucose, and blood group substances. 19654379717
immunological paralysis against type 8 and immunity against type 3 diplococcus pneumoniae induced by the soluble specific substance of type 8.brooke, marcus s. (massachusetts institute of technology, cambridge). immunological paralysis against type viii and immunity against type iii diplococcus pneumoniae induced by the soluble specific substance of type viii. j. bacteriol. 90:1296-1303. 1965.-mice injected with relatively large quantities of the soluble specific substance of type viii diplococcus pneumoniae (sviii) are, on the basis of challenge experiments, paralyzed against type viii but immune against type iii d. pneumoniae. their ...19654379004
genetic recombination in dna-induced transformation of pneumococcus. ii. mapping the amia region. 19654379828
the bacterial induction of homograft sensitivity. ii. effects of sensitization with staphylococci and other microoorganisms.heat-killed strains of staphylococcus aureus and staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or group a streptococci. challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. other bacteria tested included lancefield s ...19654379017
conversion of immunological paralysis to immunity by endotoxin. 19654378605
low frequency of co-integration of two linked streptomycin-resistance markers in pneumococcus. 19654379586
pneumococcal types detected in throat cultures from a population of "normal" families. 19654378821
the isomerization and transesterification of phosphodiester groups in phospholipids. 19654379797
[on the differential sensitivity of genetic markers to ultraviolet rays, and reactivation mechanisms during transformation in diplococcus pneumoniae]. 19654378891
neomycin blood agar for the selective culture of pneumococcus and certain other bacteria. 19654378902
bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. ii. chemoprophylaxis with daily chloramphenicol. 19654378906
cryoglobulinaemia in rabbits hyperimmunized with a polyvalent pneumococcal vaccine. 19654378913
transfer factor and autoimmune disease. 19654379060
susceptibility of pneumococci to nine antibiotics. 19654378532
effect of sublethal concentrations of penicillins on the lysis of bacteria by lysozyme and trypsin. 19654379190
pyrrolnitrin, a new antifungal antibiotic. microbiological and toxicological observations. 19654379208
morphological changes of bacteria induced by chemotherapeutic agents. 3. 19654379209
the native, denatured and renatured states of deoxyribonucleic acid. 19654379235
relative frequencies of different kinds of spontaneous and induced mutants of pneumococci and streptococci capable of growth in the presence of streptomycin.ravin, arnold w. (university of rochester, rochester, n.y.), and ajit k. mishra. relative frequencies of different kinds of spontaneous and induced mutants of pneumococci and streptococci capable of growth in the presence of streptomycin. j. bacteriol. 90:1161-1173. 1965.-mutations conferring ability to grow in the presence of streptomycin arise spontaneously and can be induced in pneumococci and streptococci. they prove to be of several phenotypic and genetic types, which may be classified as f ...19654379002
relationship between the competence antigen and the competence-activator substance in pneumococci.tomasz, alexander (the rockefeller institute, new york, n.y.), and samuel m. beiser. relationship between the competence antigen and the competence-activator substance in pneumococci. j. bacteriol. 90:1226-1232. 1965.-antisera prepared against pneumococci in their competent phase inhibit deoxyribonuoleic acid (dna)-mediated genetic transformation as well as binding of radioactive dna by the cells. the same sera do not inhibit transformation of competent haemophilus influenzae and bacillus subtil ...19654379003
clinical use of sodium nafcillin in pediatric practice. 19654378651
streptococcal red-cell-sensitizing antigens. 19654378543
[oxacillin macroorganism]. 19654378687
the polysaccharide of shigella dysenteriae and its cross-reactions with antisera to the pneumococcal types ii and vi. 19654378688
the immunological behaviour of mature c57bl-6j mice thymectomized at birth. 19654378691
some serological characteristics of normal incomplete cold antibody. 19654378755
horse anti-si immunoglobulins. i. properties of gamma-m-antibody. 19654160295
value of dilute inocula in cultural examination of sputum. 19654159135
synthesis of several mesoionic 1,3,4-thiadiazoles. 19654378942
[study of whooping cough using lung tissue culture. 3. behavior of the lung cells of young cats in tissue culture toward bordetella pertussis]. 19654380097
some structural features of the antigenic groupings involved in the cross reaction of oat glucan with type 8 horse antipneumococcal serum. 19654380106
[meningitis caused by diplococcus pneumoniae]. 19655886467
the occurrence of glycolipids in gram-positive bacteria. 196514340076
influence of deoxyribonucleic acid degradation products and orthophosphate on uptake of deoxynucleosides in pneumococcus type 3.firshein, william (wesleyan university, middletown, conn.), and bernadette a. gargan. influence of deoxyribonucleic acid degradation products and orthophosphate on uptake of deoxynucleosides in pneumococcus type iii. j. bacteriol. 90:337-342. 1965.-the uptake of specific c(14)-deoxynucleosides by a type iii encapsulated (virulent) strain of pneumococcus in resting-cell suspensions is enhanced when such deoxynucleosides are added as part of a supplement consisting of other deoxynucleosides, deoxy ...196514329444
the consistency of in vitro microbial response: a survey of the americas, europe and japan. 196514318054
dicloxacillin. in vitro and pharmacologic comparisons with oxacillin and cloxacillin. 196514325906
influence of deoxyribonucleic acid degradation products and orthophosphate on deoxynucleotide kinase activity and deoxyribonucleic acid synthesis in pneumococcus type 3.firshein, william (wesleyan university, middletown, conn.). influence of deoxyribonucleic acid degradation products and orthophosphate on deoxynucleotide kinase activity and deoxyribonucleic acid synthesis in pneumococcus type iii. j. bacteriol. 90:327-336. 1965.-an oligodeoxynucleotide fraction derived from a deoxyribonuclease-treated calf-thymus deoxyribonucleic acid (dna) can enhance the activity of deoxycytidylic acid (dcmp) and deoxyguanylic acid (dgmp) kinases in cell suspensions of type i ...196514329443
anti-dna antibodies in hyperimmunized rabbits.complement-fixing anti-dna antibodies were detected in a minority of sera of rabbits hyperimmunized with killed gram-negative bacteria. the c'-fixing property of dna was lost after dnase treatment. preferential reactivity with denatured dna was observed. the antisera reacted with dna preparations derived from rabbit bone marrow and thymus, calf thymus, pneumococci, salmon sperm, and escherichia coli. e. coli dna was less effective than preparations of mammalian and salmon sperm dna in fixation o ...196514264274
failure of pretreatment with glucocorticoids to modify the phagocytic and bactericidal capacity of human leukocytes for encapsulated type i pneumococcus.allison, fred, jr. (university medical center, jackson, miss.), and martha h. adcock. failure of pretreatment with glucocorticoids to modify the phagocytic and bactericidal capacity of human leukocytes for encapsulated type i pneumococcus. j. bacteriol. 89:1256-1261. 1965.-the influence of glucocorticoid administration for 4 days upon the bactericidal and phagocytic functions of leukocytes recovered from venous blood of healthy human beings was evaluated within an in vitro system that contained ...196514292995
pneumococcus type lxxxii (danish type 48). 196514293021
modifications of the inactivation by ionizing radiations of the ionizing radiations of the transforming activity of dna in spores and dry cells. 196514272815
enzymatic synthesis and structure of two glycolipids from type xiv pneumococcus. 196514300740
enhancements of antibiotic activity of colicine k and alteration of serological properties of colicine k and endotoxins.hemoglobin, its chains, and myoglobin enhance the antibiotic activity of colicine k. these proteins also interact with colicine k and other o antigens to alter their serological activity. the hemoglobin proteins did not alter the serological activities of three pneumococcus polysaccharides or t4 bacteriophage dna antigens but did alter the antigenic activity of fetuin. interaction of hemoglobin and colicine k resulted in a retardation of colicine k antibiotic moiety as measured by gel filtration ...196514264271
induction of nonspecific resistance by endotoxin in unresponsive mice.margherita, s. s. (temple university school of medicine, philadelphia, pa.), and h. friedmann. induction of nonspecific resistance by endotoxin in unresponsive mice. j. bacteriol. 89:277-280. 1965.-serratia marcescens endotoxin was tested for protective effect in animals of varying immunological competence. a quantity of endotoxin capable of inducing resistance in mice to a standardized challenge of diplococcus pneumoniae was equally effective in animals immunologically paralyzed with a high dos ...196514255690
the effect of a pneumococcal product upon rabbit erythrocytes in vitro and in vivo. 196514261324
the production of antibody in the presence of interferon. 196514343494
[experimental intestinal occlusion. peritoneal bacteriology and its relation to parietal histopathology]. 196514347436
the glycolipids from a rough strain of pneumococcus type i. 196514300739
rapid method for demonstrating bile solubility of diplococcus pneumoniae. 196514329473
immunofluorescence techniques for demonstrating bacterial pathogens associated with cerebrospinal meningitis. i. clinical evaluation of conjugates on smears prepared directly from cerebrospinal fluid sediments. 196514331108
microbiological, pharmacological and clinical studies of lincomycin. 196514331943
transforming activity and dna denatured with cupric ions. 196514338778
decreased susceptibility to immunological paralysis with increased age. 196514339504
effect of pneumococcus s-3 polysaccharide on viscosity and heat transfer of human blood. 196514328882
cryptococcus neoformans polysaccharide: studies of serologic properties and role in infection. 196514321434
[heterophilic antigen receptors in the mucoid fraction from sheep erythrocyte stroma: dp-xivho, rc, rhst and monhu]. 196514322777
antifungal activity of a series of substituted ((alpha-nitroalkyl)benzylthio)alkylamines. 196514323149
effect of naturally occurring xanthines on bacteria. i. antimicrobial action and potentiating effect on antibiotic spectra.the effect of xanthines on various microorganisms was studied. the antibacterial effect was not high; most of the test organisms could easily withstand a concentration of 2,500 mug/ml. caffeine was more antibacterial than theophylline, and the latter more than theobromine. caffeine citrate exhibited greater inhibitory effect than did pure caffeine. the effect was both bacteriostatic and bactericidal against susceptible organisms. the susceptibility of organisms to xanthines differed greatly even ...196514325283
in vitro and in vivo laboratory evaluation of cephaloglycin and cephaloridine.two new antibiotics, structurally related to cephalothin, have been given the generic names cephaloglycin and cephaloridine. cephaloglycin is the dipolar ion of 7-(d-alpha-aminophenylacetamido)-cephalosporanic acid. cephaloridine is 7-[alpha-(2-thiophene)acetamido]-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine. these new compounds were evaluated simultaneously. the broad spectrum of activity observed in vitro and in vivo with both antibiotics, the good oral absorption obtained with ceph ...196514325888
the bacteriology and chemotherapy of chronic bronchitis. 196514283436
respiratory illness in factory and office workers. a study of minor respiratory illnesses in relation to changes in ventilatory capacity, sputum characteristics, and atmospheric pollution. 196514283437
interaction of laser radiation with biologic systems. 3. studies on biologic systems in vitro. 196514283538
kinetics of the potassium- and sodium-activated infection of a transforming deoxyribonucleic acid in pneumococcus. 196514287199
bacteriological investigation in bronchoscopy. 196514256354
studies on the pathogenesis of meningitis. v. action of penicillin in experimental pneumococcal meningitis. 196514260698
recurrent pneumococcal meningitis. a review of the literature and studies on a patient who recovered from eleven attacks caused by five serotypes of diplococcus pneumoniae. 19665936411
[genetic recombination in transformation in pneumococcus. study of the reversions to the amia locus]. 19664380121
on the nature of the pneumococcal activator substance. 19664380138
enzymatic breakdown of uv-irradiated dna by the extract from micrococcus lysodeicticus. 19664381614
cross infection produced by tetracycline-resistant pneumococci. 19664380139
cross-reactions of streptococcal group n teichoic acid in antipneumococcal horse sera of types vi, xiv, xvi, and xxvii. 19664380156
serologic and genetic relationships between pneumococci and other respiratory streptococci. 19664380916
dl-2,6-diamino-4-hexynoic acid, a growth inhibitor. 19664381263
the enzymatic synthesis of dihydrofolate and dihydropteroate in cell-free preparations from wild-type and sulfonamide-resistant pneumococcus. 19664380073
the discovery of pneumococcal type transformation: an appreciation. 19664380083
differential effects of deoxyribonucleotides on respiration of virulent pneumococci.firshein, william (wesleyan university, middletown, conn.), robert j. erickson, and bernadette a. gargan. differential effects of deoxyribonucleotides on respiration of virulent pneumococci. j. bacteriol. 92:1645-1654. 1966.-four naturally occurring deoxyribonucleotides affect respiration in three virulent pneumococcal types (diplococcus pneumoniae) differentially. deoxyadenylic acid (damp) stimulates respiration in type i and slightly stimulates respiration in type iii, but has no effect in typ ...19664381109
fractionation of denatured pneumococcal dna: evidence for resolution of complementary strands. 19664381594
bacterial glycolipids. glycosyl diglycerides in gram-positive bacteria.1. the lipids of ten gram-positive bacteria have been isolated and the presence in each of a glycosyl diglyceride was established. 2. the glycolipid fractions were isolated and deacylated to give water-soluble glycosides which were purified by paper chromatography. partial structures for the glycosides have been deduced from chemical and enzymic studies. 3. nine of the glycosides were disaccharides glycosidically linked to the 1-position of glycerol: the remaining glycoside contained a trisaccha ...19664381586
separation of native and denatured fractions from partially denatured pneumococcal dna. 19664381593
the type-specific substance from pneumococcus type 10a(34). the phosphodiester linkages.1. the phosphate groups in the type-specific substance s. 10a from pneumococcus type 10a (34) were shown to join the hydroxyl group at position 1 or 5 of ribitol and the hydroxyl group at position 5 or 6 of a d-galactofuranosyl residue in the next repeating unit. 2. a partial formula of the type-specific substance was derived.19664381846
on the mechanism of integration of transforming deoxyribonucleate.the characteristics of the intermediates in the reaction, between dna and pneumococcus, that results in genetic transformation are described in so far as they have been characterized. transformation with dna isolated from bacteria carrying in addition to genetic markers (32)p as a radioactive label and (2)h and (15)n as density labels has permitted the characterization of the product of recombination between the newly introduced dna and the dna of a recipient bacterium. the evidence for a single ...19664381781
the type-specific substance from pneumococcus type 10a(34). structure of the dephosphorylated repeating unit.1. a hexasaccharide unit was isolated from the specific substance s. 10a from pneumococcus type 10a (34) by hydrolysis with alkali followed by enzymic dephosphorylation. 2. the hexasaccharide was shown to be o-d-galactofuranosyl-(1-->3)-o-d- galactopyranosyl-(1-->4)-o-[d-galactofuranosyl- (1-->6)]-o-2-acet-amido-2-deoxy-d-galactopyranosyl- (1-->3)-o-d-galactopyranosyl-(1-->2)-ribitol.19664381845
genetic studies of recombining dna in pneumococcal transformation.the results of genetic fine structure experiments, performed on the amia locus of pneumococcus are summarized. the peculiar feature of transformation genetics is that a given donor marker mutation transforms with an efficiency characteristic of the mutated site. in spite of this difficulty, mapping procedures have been devised and quantitative recombination studies performed. it is concluded from these studies that transformation, in this locus, is the consequence of frequent, and essentially ra ...19664381782
the specific substance from pneumococcus type 34 the configuration of the glycosidic linkages.1. the specific compound from pneumococcus type 34 was isolated from capsular material by ion-exchange chromatography. this separated it from a substance with chemical and serological properties corresponding to those reported for c-substance. 2. the configuration of the two galactofuranosyl linkages in the repeating unit of s.34 was determined and the configurations previously assigned to the other glycosidic linkages were confirmed. 3. the dephosphorylated deacetylated repeating unit is thus o ...19664381831
[basic and clinical studies on methyldichlorophenylisoxazolyl penicillin (staphcillin a)]. 19664381834
the chemical, spectral, and biological properties of monomethine cyanine dyes containing 1,3-benzoxazine and quinazoline nuclei. 19664381839
laboratory and clinical studies of a new antibiotic, cephaloridine, in the treatment of gram-positive infections. 19664382527
[transformation]. 19664382695
a differential solvent effect on thermal stability of genetic markers in dna. 19664381892
the susceptibility of pneumococci to eight antimicrobial agents. 19664382699
a suggested mechanism for the selective procedure for isolating thymine-requiring mutants of escherichia coli. 19664381707
[incidence of optochin resistant mutants in a strain of diplococcus pneumoniae]. 19664383457
[etiological changes in pneumonia]. 19664385142
[dynamics of the change of the composition of microflora and its sensitivity toward antibiotics in purulent inflammatory processes of lungs]. 19664385185
[experiences with lincomycin from the clinic and laboratory]. 19664385186
[antibiotic activity of the methacycline-triacetyl-oleandomycin association]. 19664384277
[bacteriological and pharmacological properties of new cephalosporin antibiotics. i. cephalothin. 2]. 19664385598
[on the anatomy and clinical significance of the canalis ethmoidalis]. 19664384327
[bacteriological findings in bartholinitis]. 19664386010
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