Publications

naturally occurring nad-independent haemophilus parainfluenzae.	four, nad-independent, clinical isolates of haemophilus parainfluenzae were recovered from a genital ulcer, a purulent skin lesion, a sputum specimen and a throat swab respectively. with the exception of nad requirement, the strains exhibited the biochemical characteristics of h. parainfluenzae biotype ii. the genetic relationship between these isolates and a standard strain of h. parainfluenzae was determined by testing transforming activities of two chromosomal markers, streptomycin resistance ...	1990	2384741
[haemophilus parainfluenzae as a cause of urinary tract infection].		1990	1708681
[clinical evaluation of cefdinir 5% fine granules in pediatrics].	clinical evaluation in pediatrics on cefdinir (cfdn, fk482) (5% fine granules), a new oral cephem, was performed. 1. cfdn was administered to 112 pediatric patients with ages between 1 month to 13 years with various infections. dose levels used were 3.0-8.9 mg/kg (mean 5.1 mg/kg) t.i.d. for 3-14 days (mean 6.7 days). the studied patients included 2 patients with scarlet fever, 6 with acute pharyngitis, 6 with acute rhinopharyngitis, 52 with acute purulent tonsillitis, 8 with acute bronchitis, 24 ...	1991	1762167
[pharmacokinetic, bacteriological and clinical studies on cefdinir fine granules in the field of pediatrics].	the pharmacokinetics and clinical effectiveness of cefdinir (cfdn, fk482) were examined in pediatric patients. the results are summarized as follows. 1. plasma concentrations and urinary excretions of cfdn after administration of 5% fine granules were investigated on 4 children at a dose level of 6 mg/kg. average plasma concentrations peaked at 4 hours after administration at 0.99 micrograms/ml with a half-life of 2.12 hours. the first 24-hour urinary recovery rates of cfdn in 3 children average ...	1991	1762171
recombinant human insulin-like growth factor i: effects in normal subjects and implications for use in patients.		1991	1767745
treatment of acute exacerbations of chronic bronchitis: state of the art.	effective treatment of acute bacterial exacerbations of chronic bronchitis (abe) reduces the number of such exacerbations in such patients and may decrease or eliminate background symptoms and improve pulmonary function. the pathologic and physiologic abnormalities of the bronchial system in chronic bronchitis that predispose to bacterial infection probably include impaired mucociliary clearance, obstructed bronchioles, and bacterial infections of the bronchial epithelium. exacerbations of bronc ...	1991	1767808
the biting rate of triatoma infestans in argentina.	1. the daily proportion of fed individuals in a population of the reduviid bug triatoma infestans (klug), maintained under natural climatic conditions in experimental chicken houses in central argentina, was estimated from the proportion of bugs retaining colourless urine in the rectum. 2. from the estimates of feeding frequency throughout a 1 year period, it was shown that temperature has a dominant effect on biting rate, but density-dependent effects became apparent during the warmest months. ...	1991	1768924
plasmid-mediated nad independence in haemophilus parainfluenzae.	the location of the genes coding for nad independence in four unusual clinical isolates of haemophilus parainfluenzae was determined by transferring these genes to plasmid-free haemophilus influenzae rd by transformation and analysing transformants for the presence of plasmids by agarose gel electrophoresis. all nad-independent transformants were found to carry a single plasmid species. the plasmids, originally harboured by the four h. parainfluenzae isolates recovered from unrelated sources, we ...	1991	1770356
persistent diarrhea: total gut transit time and its relationship with nutrient absorption and clinical response.	the study was undertaken to better understand the role of total gut transit time (tgtt) on the absorption of nutrients in patients with persistent diarrhea. twenty-six boys aged 3-18 months with persistent diarrhea and 25 age-matched healthy controls were studied. their tgtt was measured with charcoal markers during their treatment with a diet made up with rice powder soya oil, glucose, and egg white. coefficients of absorption of nutrients were estimated in a 72-h balance study. the median tgtt ...	1991	1779316
tissue adhesives inhibit experimental new bone formation.	the effect of the cyanoacrylate tissue adhesive histoacryl on new bone formation was studied in rats. experimental heterotopic new bone formation was induced by implanting pieces of demineralized allogeneic bone matrix (dabm) in the abdominal wall of 10 growing sprague-dawley rats. this produces cartilage formation within and around the implants after 10 days, followed by enchondral ossification and the formation of an ossicle with remodelling bone and bone marrow after three weeks. prior to imp ...	1991	1809713
[pharmacokinetic and clinical studies of cefpirome in pediatric field].	we conducted a study on the pharmacokinetics and clinical application of cefpirome (cpr) in children. 1. a single intravenous injection of 20 mg/kg of cpr was given to a two-month-old boy, and the concentration of the drug in the blood was measured. fifteen minutes after administration, the concentration was 53.3 micrograms/ml, and it gradually decreased thereafter, reaching a level of 5.18 micrograms/ml after 8 hours with a half-life in the plasma of 2.36 hours. 2. a single intravenous injectio ...	1991	1828275
ability of dna and spermidine to affect the activity of restriction endonucleases from several bacterial species.	previous work has described the novel ability to modulate in vitro the activity of restriction endonuclease naei from nocardia aerocoligenes by using cleavable dna and spermidine [conrad & topal (1989) proc. natl. acad. sci. u.s.a. 86, 9707-9711]. in this paper we report the results of a study of 49 type ii restriction enzymes from a variety of bacterial species. on the basis of the rates of cleavage observed, we found that in addition to expected cleavable sites a number of enzymes had slow and ...	1991	1848100
[embolic retinitis in haemophilus parainfluenzae endocarditis].	infectious embolic retinopathy occurring secondary to a bacterial endocarditis is described in a 38-year-old woman with known aortic disease. the infectious organism was a haemophilus parainfluenzae confirmed by serial blood cultures and characterized by an embolic power equal to fungal infection. after four-weeks period of appropriate and intensive antibiotic therapy, blood cultures became negative but new emboli were observed in the fundus. this report describes ocular lesions rarely observed ...	1991	1880339
[bacteriological, pharmacokinetic and clinical studies of cefpirome in the field of pediatrics].	bacteriological, pharmacokinetic and clinical studies on cefpirome (cpr, hr 810), a new cephem antibiotic, were carried out in the field of pediatrics. the results obtained are summarized below. 1. antibacterial activities of cpr against clinically isolated strains of staphylococcus aureus, streptococcus pneumoniae, streptococcus pyogenes, streptococcus agalactiae, escherichia coli, klebsiella pneumoniae, haemophilus influenzae and haemophilus parainfluenzae were superior to those of ceftazidime ...	1991	1880922
effect of dihydrotestosterone on the rate of ethanol elimination in healthy men.	testosterone (t) and, more potently, dihydrotestosterone (dht), are in vitro inhibitors of hepatic alcohol dehydrogenase (adh). an increase in the rate of ethanol disappearance (red) in man has been observed after orchidectomy. we thus investigated the influence of dht administration on red in 10 healthy male volunteers. red was estimated after an oral ethanol bolus (0.6 g/kg), before and after a 14-day treatment with dht (2 x 125 mg per day percutaneously; andractim, besins iscovesco, france). ...	1991	1905499
the hiv core protein p24 inhibits interferon-gamma-induced increase of hla-dr and cytochrome b heavy chain mrna levels in the human monocyte-like cell line thp1.	cells from the human monocytic cell-line thp1 were incubated prior to activation with ifn-gamma or lps with varying amounts of p24, the main product of the hiv gag gene and the major component of the virus core. the ifn-gamma-dependent increase of mrna for hla-dr and for the heavy chain of cytochrome b was markedly decreased by p24 but not by gp120. this effect was abrogated by anti-p24 antibodies. on the other hand, preincubation of thp1 cells with p24 did not affect the accumulation of the lps ...	1991	1905983
posttranslational cleavage of rat intestinal lactase occurs at the luminal side of the brush border membrane.	the intestinal sucrase-isomaltase precursor is cleaved at the brush border membrane by luminal proteases. whether the lactase precursor also is cleaved by luminal proteases is uncertain. lactase synthesis and processing was studied in 0- and 15-day-old rats after ip administration of [35s]methionine, and changes in precociously cortisone-induced sucrase-isomaltase were used as an internal control. mucosal lactase and sucrase-isomaltase were separately immunoprecipitated and analyzed by autoradio ...	1991	1906027
clinical and microbiologic features of urethritis in men in toulouse, france.	on hundred twenty-six men who attended a hospital microbiology laboratory and 99 men who attended a private laboratory in toulouse, france, for symptoms of urethritis were examined during 1988, for evidence of urethral pathogens. the following incidences were found: neisseria gonorrhoeae: 24 (10.7%); chlamydia trachomatis: 58 (25.8%); ureaplasma urealyticum: 46 (20.4%); gardnerella vaginalis: 21 (9.3%); haemophilus parainfluenzae: 21 (9.3%); streptococcus agalactiae: 15 (6.7%); candida albicans: ...	1991	1907404
haemophilus parainfluenzae as a rare cause of epidural abscess: case report and review.	we report a case of epidural abscess due to haemophilus parainfluenzae. this microorganism is a normal inhabitant of the upper respiratory tract that causes endocarditis and, rarely, other invasive infections. to the best of our knowledge, epidural abscess due to h. parainfluenzae has not been reported previously. a 74-year-old man presented with neck pain and subsequently developed incomplete quadriparesis. a cervical epidural abscess and vertebral osteomyelitis were detected by radiologic stud ...	1991	1925278
haemophilus parainfluenzae endocarditis treated with vegetectomy and complicated by late, fatal splenic rupture.		1991	1945581
haemophilus parainfluenzae causing sexually transmitted urethritis. report of a case and evidence for a beta-lactamase plasmid mobilizable to escherichia coli by an inc-w plasmid.	a multiple antibiotic resistance, beta-lactamase-producing strain of haemophilus parainfluenzae was isolated from a patient with sexually transmitted urethritis that was contracted in northwest africa. the strain was found to harbor a small (3.2 megadaltons) plasmid encoding for beta-lactamase production, which was successfully mobilized to escherichia coli in triparental mating experiments by means of a broad host-range inc-w conjugative plasmid. since h. parainfluenzae is believed to be a sour ...	1991	1948515
comparison of two commercial kits for identifying and biotyping haemophilus parainfluenzae.	the minitek system and the more recently introduced micro scan hnid panels for the identification and biotyping of 98 v dependent haemophilus isolates were compared. identical results were obtained for 77 isolates. the discrepancy in the results of ornithine and urease was accounted for mainly by the mismatching of the identification by the two kits. when 13 isolates of h parainfluenzae with mismatched biotypes were re-examined, the results from micro scan correlated with 92% of those obtained b ...	1991	1997542
urinary tract infection caused by haemophilus parainfluenzae.		1991	2002240
[clinical evaluation of cefixime in pediatric respiratory tract infections].	cefixime (cfix) was evaluated clinically in pediatric respiratory tract infections, particularly those caused by haemophilus influenzae: 1. the total number of children in this study treated with cfix was 232, out of which 215 cases were evaluated for clinical efficacy and 224 cases were investigated for safety. a daily dosage of 3-6 mg/kg/day was given divided into 2 to 3 times daily for 3-15 days. 2. causative organisms were identified in 146 cases, out of which 128 cases were found to be sing ...	1991	2041146
prosthetic joint infection due to haemophilus parainfluenzae after dental surgery.		1991	2052987
[urinary tract infection caused by haemophilus influenzae and haemophilus parainfluenzae].		1992	1391008
[resistance of haemophilus influenzae and haemophilus parainfluenzae to beta-lactam antibiotics. characterization of the beta-lactamases].	we have studied the susceptibility to ampicillin and the characteristics of the beta-lactamase activity of the 169 haemophilus spp. strains (128 h. influenzae, 40 h. parainfluenzae and one h. paraphrophilus) isolated during 12 months, years 1988-1989, in the hospital del mar clinical microbiology laboratory. our objective was to know in the strains of our center the frequency of those resistant or slightly susceptible to ampicillin, the role of beta-lactamases in the loss of susceptibility and t ...	1992	1391019
a case of biliary tract infection caused by haemophilus parainfluenzae.		1992	1396738
optimum use of selective plated media in primary processing of respiratory tract specimens from patients with cystic fibrosis.	a total of 258 respiratory tract specimens from patients with cystic fibrosis were inoculated onto nine different plated media, and the rates of recovery of potential pathogens were compared. media included sheep blood agar, enriched chocolate agar, macconkey agar for gram-negative bacilli, chocolate agar containing bacitracin for haemophilus spp., bromcresol green agar for yeasts, cetrimide agar for pseudomonas spp., sheep blood agar containing colistin and nalidixic acid for gram-positive cocc ...	1992	1400978
microbiological considerations of the etiological agents of lower respiratory tract infections.	one hundred eight-four sputum specimens from the same number of patients with lower respiratory tract infections were examined to determine the bacterial count and the relationship between the microorganisms isolated and the presumptive pathology. the sputa were subdivided into three groups; "high probability", "low probability", and "contaminated sputa", following the criteria of the microscopic readings: sputum with more than 25 white cells and low numbers of squamous epithelial cells represen ...	1992	1403075
use of an adsorption enzyme immunoassay to evaluate the haemophilus ducreyi specific and cross-reactive humoral immune response of humans.	serodiagnosis of chancroid is limited by the cross-reactivity of haemophilus ducreyi with haemophilus influenzae and haemophilus parainfluenzae. this research describes an adsorption enzyme immunoassay (eia) that assesses the humoral immune response of north americans and africans to h. ducreyi. adsorption effectively removed anti-h. influenzae and anti-h. parainfluenzae antibodies, revealing that north american control sera had no residual anti-h. ducreyi reactivity. however, african control se ...	1992	1492255
[clinical study on cefprozil in pediatrics].	clinical efficacy and safety of cefprozil (cfpz, bmy-28100), a newly developed oral cephalosporin, were studied in our pediatric department. clinical effectiveness, bacteriological effectiveness and side effects were studied in 116 pediatric patients with ages ranging 4 months to 11 years. cfpz was given 4.6-14.1 mg/kg daily in 3 times for 3-10 days. clinical efficacies were evaluated in 112 patients, and the therapeutic effectiveness were excellent in 1 and good in 6 for 7 patients with acute p ...	1992	1494236
[laboratory and clinical studies on cefprozil in the field of pediatrics].	laboratory and clinical studies on cefprozil (cfpz, bmy-28100), a new cephem antibiotic, were carried out in the field of pediatrics. the results obtained are summarized as follows: 1. serum concentrations, urinary concentrations and urinary recovery rates of cfpz were determined upon oral administration of cfpz after meal at doses of 4 mg/kg granules in a case, 7.5 mg/kg granules in 2 cases and 15 mg/kg granules in one. peak serum levels of cfpz were obtained at an hour in 3 cases and at 2 hour ...	1992	1494237
cloning and expression of the hpai restriction-modification genes.	the genes from haemophilus parainfluenzae encoding the hpai restriction-modification system were cloned and expressed in escherichia coli. from the dna sequence, we predicted the hpai endonuclease (r.hpai) to have 254 amino acid residues (mr 29,630) and the hpai methyltransferase (m.hpai) to have 314 amino acid residues (37,390). the r.hpai and m.hpai genes overlapped by 16 base pairs on the chromosomal dna. the genes had the same orientation. the clone, named e. coli hb101-hpa2, overproduced r. ...	1992	1542567
biotypes of haemophilus parainfluenzae from the respiratory secretions in chronic bronchitis.	a total of 2401 isolates of haemophilus parainfluenzae was isolated from respiratory secretions of 36 healthy adults and 128 patients with chronic bronchitis over a period of 1 year. the isolates were allocated to eight biotypes, by their production of indole, urease and ornithine decarboxylase. biotypes i and ii constituted most of the isolates of h. parainfluenzae from the oropharynx of controls (75%) and chronic bronchitics (c. 90%). among the patients, there was no difference in the isolatio ...	1992	1560450
early diagnosis of vertebral osteomyelitis due to a rare pathogen: haemophilus parainfluenzae.	bone and joint infections due to haemophilus parainfluenzae are unusual. we describe a case of hematogenous vertebral osteomyelitis caused by this commensal microorganism of nose and oropharynx. early diagnosis and therapy were possible within a week using sensitive radiologic methods: technetium bone scanning, computed tomography and magnetic resonance imaging.	1992	1578470
the clinical significance of haemophilus influenzae and h. parainfluenzae isolated from the sputum of adult patients at an urban general hospital.	fifty-seven patients, from whose sputum haemophilus influenzae (49 cases) or haemophilus parainfluenzae (8 cases) was isolated during a 7-month period, were studied. in the majority of cases there were well-defined predisposing factors to respiratory tract colonisation or infection with the isolates, in particular bronchiectasis and chronic obstructive airways disease. colonisation of the airways, bronchopneumonia in patients with underlying lung disease, acute lobar pneumonia, and postoperative ...	1992	1585219
[a study on in vitro antibacterial activity and clinical usefulness in respiratory tract infections of panipenem/betamipron, a newly synthesized carbapenem antibiotic].	panipenem/betamipron (papm/bp) is a combination drug of papm, a new parenteral carbapenem antibiotic and bp, an amino acid derivative at a weight ratio of 1:1. its in vitro antibacterial activities against clinically isolated respiratory pathogenic bacteria were determined. it was superior to imipenem (ipm) in the in vitro antibacterial activities against haemophilus influenzae, haemophilus parainfluenzae, branhamella catarrhalis, staphylococcus aureus including mrsa, klebsiella pneumoniae, serr ...	1992	1613967
in vitro activity of a new broad-spectrum, beta-lactamase-stable oral cephalosporin, cefixime, in comparison with other drugs, against haemophilus influenzae, haemophilus parainfluenzae, moraxella catarrhalis and streptococcus pneumoniae.	cefixime, a new orally absorbed iminomethoxyaminothiazolyl cephalosporin, was tested against some microorganisms involved in upper and lower respiratory tract infections such as haemophilus (influenzae and parainfluenzae), moraxella catarrhalis and streptococcus pneumoniae, isolated in the period from november 1990 to april 1991. its activity was compared to nine other antimicrobial agents: erythromycin, trimethoprim-sulfamethoxazole, ampicillin, amoxicillin-clavulanate, cefaclor, ceftazidime, c ...	1992	1618002
determination of haemophilus influenzae and haemophilus parainfluenzae susceptibility to ampicillin and other antibiotics.	a sample comprising 40 h. influenzae and 74 h. parainfluenzae strains was used to verify methods for determining susceptibility to antibiotics. modified levinthal agar proved to be suitable for the agar dilution and agar diffusion method, while brain heart infusion with the thermally released components of sheep blood (x and v factor) and lysed horse blood performed well in the dilution micromethod. the iodometric method served well for beta-lactamase production. a substantial proportion of stra ...	1992	1619296
review of behavior on a disk from cms academic software: instructional programs for teaching teachers.	the programs on boad represent a set of useful simulations and demonstrations of learning phenomena that successfully convey important practical and theoretical information to students. the most successful modules deal with shaping and the selective effect of positive reinforcement on behavior. the range of examples is sufficiently broad to convey the generality of these learning phenomena, but the graphics and particular examples are better suited to the college classroom (for which they were d ...	1992	1626085
total hepatic mesh wrap for hemostasis.	to improve hemostasis and avoid the complications of perihepatic packing, a technique of hepatic tamponade using total mesh wrap is reported. the method is geometrically, technically and mechanically feasible and appears to be effective in controlling severe parenchymatous bleeding.	1992	1636144
differential regulation of mrnas encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase c.	protein-tyrosine phosphatases (ptpases) play an essential role in the control of signalling through phosphotyrosine pathways. since little is known about the regulation of these enzymes, we examined the effect of insulin and phorbol 12-myristate 13-acetate (pma) treatment of well-differentiated rat hepatoma (fao) cells on the expression of mrnas encoding three major ptpase homologs in liver: ptpase1b, an intracellular enzyme with a single conserved ptpase domain, and two tandem-domain, transmemb ...	1992	1280135
myocardial protection by retrograde cardioplegic perfusion in the presence of acute coronary artery obstruction. an experimental study.	to investigate retrograde delivery of cardioplegic solutions as a means of enhancing myocardial protection in the presence of coronary artery occlusion, a two-part experimental model was devised. in part 1 (in vitro) the possibility of retroperfusing the entire myocardium during acute occlusion of the left anterior descending artery (lad) was assessed. in part 2 (in vivo) acute lad occlusion was performed in dogs, and during 2 hours of aortic cross-clamping crystalline cardioplegic solution was ...	1992	1287835
assessment of the lifetime accumulated cadmium intake from food in kempenland.	research in 1984 indicated that the cadmium body burden was higher in a village where the soil is contaminated with cadmium (luyksgestel) than in a control village (zeeland). the distribution of kidney function parameters also differed between the two villages. the aim of this study is to estimate the lifetime accumulated cadmium intake from food for the people from both villages. various data sets describing dietary patterns in the netherlands were used. the assessed average lifetime accumulate ...	1992	1287841
[clinical studies on cefprozil granules].	cefprozil granule preparation was administered orally to 16 patients (ages ranging 8 months to 9 years and 6 months) with pediatric bacterial infections at daily dose levels between 29.4 and 35.7 mg/kg divided into 3 or 4 doses. the following results were obtained. 1. sixteen patients including 5 with pharyngitis, 3 with tonsillitis, 3 with lacunar tonsillitis, 2 with pneumonia, 2 with contagious impetigo and 1 with scarlet fever were treated. clinical effects were excellent in 9 cases and moder ...	1992	1289582
a site on rod g protein alpha subunit that mediates effector activation.	the heterotrimeric guanine nucleotide binding proteins (g proteins) are activated by sensory or hormone receptors. in turn, the g proteins activate effector proteins such as adenylyl cyclase, cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde), phospholipase c, and potassium and calcium ion channels by mechanisms that are poorly understood. a site on the alpha subunit of the g protein transducin (alpha t) has been identified that interacts with and activates cgmp phosphodiesterase, ...	1992	1317058
hypoxia modulates mediator responses and neurotransmission in guinea-pig trachea in vitro.	to discover whether hypoxia affects mediator responses and neurotransmission in tracheal smooth muscle, we studied in vitro tracheal segments from guinea-pigs under isometric conditions. hypoxia itself did not alter the basal tone. the maximum response to acetylcholine and histamine under hypoxia was less than that under oxygenated conditions. the logarithm of 50% effective concentration (log ec50) of the response to acetylcholine under hypoxia was not altered, but the log ec50 of the response t ...	1992	1317230
double-blind randomized study comparing the efficacies and safeties of a short (3-day) course of azithromycin and a 5-day course of amoxicillin in patients with acute exacerbations of chronic bronchitis.	the efficacies and safeties of a three-dose regimen of azithromycin (500 mg once daily for 3 days) and a 15-dose regimen of amoxicillin (500 mg three times daily for 5 days) were compared in a double-blind manner in patients with an acute exacerbation of chronic bronchitis. a total of 92% of patients suffered a type 1 exacerbation. treatment success, defined as cure or major improvement, was achieved in all patients in the azithromycin group by day 5, compared with 23 (92%) of 25 patients in the ...	1992	1324645
clustering of an outer membrane adhesin of haemophilus parainfluenzae.	haemophilus parainfluenzae synthesizes an outer membrane protein adhesin which mediates binding to oral streptococci, salivary pellicle, and neuraminidase-treated erythrocytes. an indirect gold labeling technique and immunoelectron microscopy verified the location of this outer membrane protein. further, a clustering of gold particles was observed in irregular patches at the cell surface.	1992	1730505
application of multivariate analyses of enzymic data to classification of members of the actinobacillus-haemophilus-pasteurella group.	outer membrane vesicles and fragments from actinobacillus actinomycetemcomitans, actinobacillus lignieresii, actinobacillus ureae, haemophilus aphrophilus, haemophilus paraphrophilus, haemophilus influenzae, haemophilus parainfluenzae, pasteurella haemolytica, and pasteurella multocida were isolated and examined semiquantitatively for 19 enzyme activities by using the api zym micromethod. the enzyme contents of vesicles and fragments were compared with the enzyme contents of whole cells of the s ...	1992	1736960
[critical study of the evaluation of vital signs and electrocardiogram in patients with acute coronary insufficiency after bed bath].		1992	257685
psychosocial factors and health. world health assembly.		1992	191603
phylogeny of the pasteurellaceae as determined by comparison of 16s ribosomal ribonucleic acid sequences.	previously, virtually complete 16s ribosomal ribonucleic acid sequences were determined for 54 strains of species in the family pasteurellaceae. the sequences for 16 additional strains have been determined, bringing the total number of strains sequenced to 70. the additional strains include: actinobacillus hominis, a. muris, a. salpingitis, pasteurella bettyae, p. mairii, p. testudinis, and bisgaard taxa 2, 3, 5, 6, 7, 8, 9, 13, and 14 (2 strains). a phylogenetic tree was constructed based upon ...	1993	7690271
haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse.	haemophilus parainfluenzae is a frequent cause of "culture-negative" endocarditis (i.e., endocarditis owing to a fastidious organism which may require longer incubation periods and/or enrichment media for detection compared to traditional pathogens). more cases will probably be identified with improvements in growth and isolation techniques. a case of h. parainfluenzae endocarditis is presented in a patient with mitral valve prolapse, which illustrates the difficulty in diagnosing endocarditis w ...	1993	8323254
[haemophilus parainfluenzae meningitis in a 5-month-old infant].		1993	8053784
[clinical studies of s-1108 granules in the pediatric field].	we studied the clinical use of s-1108 granules in the pediatric field. the results are summarized as follows. 1. s-1108 was administered orally at doses ranging 6.85 and 17.6 mg/kg/day t.i.d. to 9 patients, including 5 cases of pharyngitis and 1 case each of lacunar tonsillitis, bronchitis, pneumonia and urinary tract infection. clinical efficacies were excellent in 4 cases and good in 5 cases, hence an efficacy rate of 100% was obtained. 2. haemophilus influenzae, haemophilus parainfluenzae (2 ...	1993	8107271
electron microscopy of phages in serotypes of actinobacillus actinomycetemcomitans.	actinobacillus actinomycetemcomitans, actinobacillus ureae, haemophilus aphrophilus, haemophilus paraphrophilus, haemophilus influenzae, haemophilus parainfluenzae, pasteurella haemolytica and pasteurella multocida strains were examined by transmission electron microscopy for the presence of bacteriophages. phages were detected in serotype a (suny 75) and e (uoh 1705) and in the fresh clinical isolates uoh q1243 and uoh q1247 of a. actinomycetemcomitans. phages were not found in serotype b, c an ...	1993	8152840
a comparison of cefpodoxime proxetil and cefaclor in the treatment of acute exacerbation of copd in adults.	in this multicenter, observer-blinded study, 301 patients with signs and symptoms of acute bacterial exacerbation of copd were randomized (2:1) to receive either cefpodoxime proxetil (200 mg, bid) or cefaclor (250 mg, tid) for 10 days. clinical and microbiologic evaluations were performed before treatment, during therapy (study days 3 to 5), at the end of therapy (3 to 7 days posttreatment), and at long-term follow-up (4 weeks posttreatment). the most common pretreatment isolates were haemophilu ...	1993	8222793
activity of meropenem and other antimicrobial agents against uncommon gram-negative organisms.	the in-vitro activity of meropenem and other antimicrobial agents was tested by agar dilution against 113 uncommon gram-negative pathogens. both meropenem and ceftriaxone showed the most activity against the test isolates. the potency of meropenem was greater than imipenem against pasteurella multocida, eikenella corrodens, haemophilus parainfluenzae, moraxella spp., kingella spp., and actinobacillus actinomycetemcomitans. further work is necessary to assess the in-vivo activity of meropenem aga ...	1993	8226425
growth characteristics of v factor-independent transformants of haemophilus influenzae.	haemophilus influenzae is a v factor-dependent species. a plasmid conferring v factor independence in haemophilus parainfluenzae and haemophilus ducreyi was transferred to plasmid-free h. influenzae rd by dna transformation. the growth characteristics of the transformants in a complex and a chemically defined medium were compared, and the ability of several exogenous pyridine nucleotides and precursors to support growth was examined. although the transformants appeared to be v factor independent ...	1993	8240960
[clinical evaluation of s-1108 in pediatric field].	nine pediatric patients with bacterial infections (5 cases of tonsillitis, 3 cases of impetigo and 1 case of uti) were treated with s-1108, and the efficacy and the safety were evaluated. the clinical responses to s-1108 treatment were excellent in 7 cases and good in 2. the efficacy rate was 100%. bacteriologically, the causative organisms (streptococcus pyogenes, staphylococcus aureus, haemophilus parainfluenzae and escherichia coli) were eradicated. no clinical side effects were observed. ele ...	1993	8309067
[pharmacokinetic and clinical studies of s-1108 in the pediatric field].	pharmacokinetic and clinical studies on s-1108, a new oral cephem antibiotic, were performed in the field pediatrics. the following results were obtained. 1) antibacterial activities antibacterial activities of s-1006, the active form of s-1108, were studied against clinically isolated strains of (staphylococcus aureus (n = 5), streptococcus pneumoniae (n = 6), streptococcus pyogenes (n = 3), haemophilus influenzae (n = 8), branhamella catarrhalis (n = 5) and haemophilus parainfluenzae (n = 2). ...	1993	8309075
[haemophilus parainfluenzae meningitis in an 8-year-old boy].	invasive infections caused by haemophilus parainfluenzae, a saprophyte of the respiratory tract, are exceptional and should arise suspicion of abnormalities in immunocompetence. so far, about thirty cases of h. parainfluenzae meningitis affecting neonates, infants or adults have been published. a case of such meningitis in an 8-year old boy without any risk factor is reported here.	1993	8316546
an analysis of the diversity of haemophilus parainfluenzae in the adult human respiratory tract by genomic dna fingerprinting.	a method for typing haemophilus species is described, based on the analysis of genomic dna from haemophilus parainfluenzae. the dna was extracted by a rapid method and digested with the restriction enzyme bamhi to provide a characteristic 'fingerprint'. the pattern of fragments in the ranges 1-1.6 kb, 1.6-2 kb and 2-3 kb were used to produce a numerical profile of each isolate. in total 97 isolates were examined; 88 from throat swab material isolated from the 15 members of a british antarctic su ...	1993	8348936
prevalence and biochemical properties of v factor-dependent pasteurellaceae from rodents.	organs of 1436 rats and 2839 mice were monitored for v-factor dependent pasteurellaceae. such bacteria were isolated from 21.2% of rats and from 2.4% of mice, respectively. they were most frequently cultured from the deep respiratory tract (lungs and trachea). in addition, they were found in the nasal cavity and on mucous membranes of the genital and the intestinal tract. 35 phenotypical criteria were determined for 429 isolates. based on these data, groups of bacteria showing similar biochemica ...	1993	8369581
[pharmacokinetic, bacteriological and clinical studies on cefditoren pivoxil in children].	pharmacokinetic, bacteriological and clinical studies on cefditoren pivoxil (cdtr-pi, me 1207) were performed in children. the results were as follows: 1. a total of 18 patients (19 infections) were treated with cdtr-pi. the doses ranged 2.1-3.2 mg/kg, and it was orally administered 3 times daily, for 4-10 days. clinical efficacies of cdtr-pi in 18 patients with 19 bacterial infections (3 with tonsillitis, 1 with bronchitis, 7 with pneumonia, 1 with acute maxillary sinusitis, 4 with otitis media ...	1993	8371494
[bacteriological, pharmacokinetic and clinical studies of cefditoren pivoxil in the pediatric field].	bacteriological, pharmacokinetic and clinical studies on cefditoren pivoxil (cdtr-pi, me 1207) in granules, a new oral cephalosporin, were performed in the field of pediatrics. the results are summarized below. 1. antibacterial activities: antibacterial activities of cdtr were studied against staphylococcus aureus, streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, haemophilus parainfluenzae and branhamella catarrhalis in comparison with those of cefteram (cftm), cefixime ...	1993	8371496
haemophilus parainfluenzae endocarditis.		1993	8377958
the production of porphyrins from delta-aminolaevulinic acid by haemophilus parainfluenzae.	porphyrin production by the haemin-independent haemophilus parainfluenzae in the diagnostic porphyrin test, which determines the x-factor requirement in haemophilus spp., was analysed quantitatively by applying modern high-performance liquid chromatographic (hplc) methods. ion-pair reversed-phase hplc enabled the simultaneous separation of all porphyrin intermediates and their isomers of haem biosynthesis produced by the bacteria. the ph-dependence of porphyrin production and the respective comp ...	1993	8411086
efficacy of fleroxacin versus amoxicillin in acute exacerbations of chronic bronchitis.	in a multicenter study the efficacy and safety of oral fleroxacin at 400 mg once a day and amoxicillin at 500 mg three times daily for 7 days were compared for the treatment of patients with acute bacterial exacerbations of chronic bronchitis due to drug-susceptible bacteria. a total of 194 patients were enrolled, 102 in the fleroxacin group and 92 in the amoxicillin group. of those enrolled, 22 in the fleroxacin group and 30 (29 for clinical efficacy) in the amoxicillin group were included in t ...	1993	8452169
ecology of haemophilus influenzae and haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections.	nine patients with lower respiratory tract infections were used to study in detail the effect of ampicillin or erythromycin on the colonization patterns of haemophilus influenzae and haemophilus parainfluenzae in sputum and saliva. h. influenzae was isolated from purulent sputum of eight patients before the start of treatment. ampicillin was more effective than erythromycin at clearing h. influenzae from sputum and in decreasing purulence. by careful characterization of multiple strains, the cha ...	1993	8494378
haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with iga nephropathy.	iga nephropathy may be associated with colonisation with haemophilus parainfluenzae. in patients with glomerular diseases, we examined renal-biopsy specimens for presence of bacterial antigen by immunofluorescence microscopy with rabbit antiserum against h parainfluenzae, and by enzyme-linked immunosorbent assay looked for iga antibody against h parainfluenzae in patient sera. the rabbit antiserum recognised by immunoblotting four components of h parainfluenzae outer membranes (omhp) of molecula ...	1994	7905040
[bacteriological and clinical studies of biapenem (l-627) in pediatric field].	we have carried out bacteriological and clinical studies on l-627. the results are summarized as follows. treatment with l-627 was made in 14 cases of pediatric bacterial infections including 5 cases of pneumonia and 2 cases each of tonsillitis, urinary tract infection and one case each of colitis, and phlegmon. results obtained were excellent in 11 cases, good in 2 cases and poor in one case. the bacteriological effect of l-627 was excellent, all causative organisms (staphylococcus aureus one s ...	1994	7933529
[urinary infection by haemophilus parainfluenzae in a renal transplantation patient].		1994	8011728
clarification of the structure of the ampicillin-resistance plasmid rsf0885 from haemophilus influenzae hr-885 serotype b.	the nonconjugative ampicillin-resistance plasmid rsf0885 has been reported to be as small as 2.9 mda and as large as 4.1 mda with at least two restriction enzyme maps reported. in addition, the source of the original plasmid has been reported to be haemophilus influenzae and haemophilus parainfluenzae. characterization of the source strains and sequencing data of the plasmids revealed that h. influenzae serotype b was the original source strain and that is1-k in the larger plasmid was presumably ...	1994	8019938
binding of human hemoglobin by haemophilus influenzae.	binding of biotinylated human hemoglobin to haemophilus influenzae was detected when organisms were grown in heme-deplete, but not heme-replete, conditions. hemoglobin binding was completely inhibited by a 100-fold excess of unlabelled human hemoglobin or human hemoglobin complexed with human haptoglobin. binding was only partially inhibited by rat hemoglobin, bovine hemoglobin, human globin, and bovine globin, and not at all by heme, human serum albumin, bovine serum albumin, human transferrin, ...	1994	8020748
haemophilus parainfluenzae endocarditis: application of a molecular approach for identification of pathogenic bacterial species.	haemophilus parainfluenzae is both a human oropharyngeal commensal bacterium and a cause of serious invasive disease. the fastidious growth characteristics of this organism and the poor specificity of traditional methods for species identification are likely to have led to inaccuracies in the diagnosis of infections caused by h. parainfluenzae and related organisms. we report a case of h. parainfluenzae endocarditis in which confusion related to microbial identification was resolved by the analy ...	1994	7528552
evaluation of api nh, a new 2-hour system for identification of neisseria and haemophilus species and moraxella catarrhalis in a routine clinical laboratory.	api nh is a new 2-h system (biomérieux, la balme-les-grottes, france) for the identification of most neisseria and haemophilus spp. of clinical significance and of moraxella catarrhalis and for the detection of penicillinase production. furthermore, this system allows the biotyping of haemophilus influenzae and haemophilus parainfluenzae. three hundred eighteen strains belonging to these species, previously identified by conventional methods, were tested. among the 305 strains belonging to speci ...	1994	8126177
haemophilus parainfluenzae.		1994	8067803
randomized comparative trial with ampicillin/sulbactam versus cefamandole in the therapy of community acquired pneumonia.	in a randomized prospective study ampicillin/sulbactam and cefamandole were compared in the therapy of patients hospitalized with community acquired pneumonia. patients receiving ampicillin/sulbactam (n = 37) and cefamandole (n = 38) were similar with respect to age (mean age 70 vs. 76 years respectively), clinical characteristics, severity of illness and underlying disease. pathogens isolated from patients in the cefamandole and ampicillin/sulbactam group, respectively, were streptococcus pneum ...	1994	8070432
organization and sequence of the hpaii restriction-modification system and adjacent genes.	we report the organization of the hpaii restriction and modification (r-m) system from haemophilus parainfluenzae (recognition sequence: 5'...ccgg...3'), the sequence of the gene coding for the hpaii restriction endonuclease, and the sequence of the upstream flanking dna. the hpaii system comprises two genes, hpaiim, coding for the methyltransferase (mtase; 358 amino acids (aa), 40.4 kda: product, cm5cgg), and hpaiir, coding for the restriction endonuclease (enase; 358 aa, 40.9 kda: product, c'c ...	1994	7514149
[fertility of women after conization].		1994	262992
[bacterial endocarditis: clinical aspects, therapy and course forms in 36 patients].		1994	1029922
[lesions of the central nervous system in adenovirus infections].	the investigation of the central nervous system in generalized adenoviral infection in two children showed the presence in large nuclei of the nerve cells of hyperchromic inclusions containing the antigen of adenovirus. this testifies to the possibility of developing encephalites caused by respiratory viruses.	1995	176977
extraction artifacts in the preparation of estrogen receptor.		1995	162978
affinity, conservation, and surface exposure of hemopexin-binding proteins in haemophilus influenzae.	haemophilus influenzae can acquire heme from hemopexin for use as a source of both essential porphyrin and iron. in classical ligand-binding studies, we observed time-dependent, saturable, and displaceable binding of human 125i-labelled hemopexin to intact cells of h. influenzae type b (hib) strain 760705 grown in an iron-restricted medium. from these experiments, which demonstrate that hemopexin associates with a single class of binding site, the affinities (kds) and receptor numbers were calcu ...	1995	7768617
hpaii methyltransferase is mutagenic in escherichia coli.	a genetic reversion assay to study c-to-t mutations within cg sites in dna is described. it was used to demonstrate that the presence of hpaii methyltransferase (mtase) in escherichia coli causes a substantial increase in c-to-t mutations at cg sites. this is similar to the known mutagenic effects of e. coli mtase dcm within its own recognition sequence. with this genetic system, a homolog of an e. coli dna repair gene in haemophilus parainfluenzae was tested for antimutagenic activity. unexpect ...	1995	7751315
haemophilus parainfluenzae biliary tract infection: rationale for an ascending route of infection from the gastrointestinal tract.	haemophilus parainfluenzae was isolated from a bile specimen of a 56-year-old patient with elevated liver enzymes and chronic cholecystitis. several factors contributing to nonbacteremic h. parainfluenzae infection of the biliary tract include (i) the not infrequent occurrence of h. parainfluenzae in stool specimens, (ii) the presence of an outer membrane protein similar to those found in enteric bacteria which facilitates adherence to the colonic mucosa, and (iii) an adequate supply of v factor ...	1995	8576372
haemophilus parainfluenzae: an unusual case of psoas abscess.	a case of haemophilus parainfluenzae psoas abscess in a previously healthy 36-year-old man is reported here. the absence of any bowel pathology indicates that abscess formation occurred secondary to haematogenous spread of the organism.	1995	8655214
[detection of beta-lactamase in samples obtained after tonsillectomy in children].	production of beta-lactamase was detected using a microbiological assay (guts test) in samples of tonsils, and by in haemophilus growing from the same samples of both tonsils obtained from 30 children aged 2 to 13 years (18 aged < 6 years and 12 aged > or = 6 years). two pieces from each tonsil, core and superficial, were studied. the procedure included direct microscopic examination of smears, and culture to identify haemophilus, beta-haemolytic streptococci and streptococcus pneumoniae. guts t ...	1995	7567124
[clinical and laboratory studies on sy5555 in pediatric infectious diseases].	clinical effects of sy5555 dry syrup, a new oral penem antibiotic, were analysed in 20 children with various bacterial infections. ages of the patients varied from 8 months to 14 years. doses of sy5555 were varied from 12.8 mg/kg/day to 30.5 mg/kg/day, and it was administered in 3 divided dosages. clinical efficacy rates were as follows; 6/7 in acute bronchitis, 5/5 in pharyngotonsillitis, 3/3 in acute otitis media and 2/2 in cystitis and 3/3 in impetigo contagiosa. the overall rate was 95.0% (1 ...	1995	7745813
efficacy of a three day course of azithromycin in moderately severe community-acquired pneumonia.	this study was designed to evaluate the efficacy of a 3 day course of azithromycin in low to moderately severe community-acquired pneumonia. forty patients with low to moderately severe community-acquired pneumonia (29 males, 11 females, mean age 46 +/- 17 yrs; 20 pretreated with betalactams for 2-10 days with no results before admission to hospital; 18 with evidence of co-morbidity) were enrolled in an open, randomized study with azithromycin, 500 mg q.d. oral therapy for 3 days, versus clarith ...	1995	7789484
multicenter trial of cefpodoxime proxetil vs. amoxicillin-clavulanate in acute lower respiratory tract infections in childhood. international study group.	acute lower respiratory tract infections in children are a worldwide public health problem, with an estimated 4 million potentially preventable deaths every year. until recently, penicillin and related drugs were the treatment of choice for empiric therapy of paediatric lower respiratory tract infections. however, concerns over the emergence of penicillin-resistant strains of streptococcus pneumoniae and beta-lactamase-producing strains of haemophilus influenzae and moraxella catarrhalis have le ...	1995	7792126
head and neck space infections in infants and children.	a retrospective study was performed in 117 children with head and neck space infections treated at the children's hospital of pittsburgh from january 1986 through june 1992. peritonsillar space infections were the most common (49%), followed by retropharyngeal (22%), submandibular (14%), buccal (11%), parapharyngeal (2%), and canine (2%) space infections. the most common pathogens isolated (n = 78) were the aerobes beta-hemolytic streptococcus (18%) and staphylococcus aureus (18%), the anaerobes ...	1995	7870436
comparison of wilkins-chalgren medium supplemented with nicotinamide adenine dinucleotide and haemophilus test medium for susceptibility testing of clinical haemophilus isolates.	haemophilus test medium (htm) was compared with wilkins-chalgren agar (wca; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (nad)) for antibiotic susceptibility testing of 74 clinical isolates of haemophilus influenzae and haemophilus parainfluenzae. the bauer-kirby agar disk diffusion method and the agar dilution procedure were the two tests employed. wca + nad and htm yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxic ...	1995	8529434
effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis.	five hundred thirty-seven patients were enrolled in two independent, investigator-blinded, multicenter, randomized clinical trials comparing the clinical and bacteriologic efficacies and the safety of 5- or 10-day treatment with cefuroxime axetil with those of 10-day treatment with amoxicillin-clavulanate in the treatment of secondary bacterial infections of acute bronchitis. patients received either 5 or 10 days of treatment (n = 177 in each group) with cefuroxime axetil at 250 mg twice daily o ...	1995	8585739
clinical comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of patients with secondary bacterial infections of acute bronchitis.	two independent, investigator-blinded, multicenter, randomized clinical trials compared the clinical and bacteriologic efficacy and safety of two oral antibiotics, cefuroxime axetil and amoxicillin/clavulanate, in the treatment of patients with secondary bacterial infections of acute bronchitis (hereafter denoted acute bronchitis). three hundred sixty patients with signs and symptoms of acute bronchitis were enrolled at 22 centers and were randomly assigned to receive 10 days of treatment with e ...	1995	8595638
[balanitis and infectious agents. a prospective study of 100 cases].	the aim of this study was: 1) to evaluate the rate of micro-organism isolation in 100 patients consulting for balanitis at the centre of sexually transmitted diseases at the st. louis hospital in paris in comparison with that of micro-organisms isolated in 60 men without balanitis; 2) to search for a possible correlation between the clinical aspect of the disease and the nature of the infectious agent identified.	1995	8745679
effect of titanium on selected oral bacterial species in vitro.	titanium granules were tested for their antibacterial effect on strains of streptococcus sanguis, streptococcus mitis, actinomyces naeslundii, haemophilus parainfluenzae, fusobacterium spp. and prevotella intermedia in comparison with amalgam and two of its components, copper and tin. glass beads were used as controls. the number of viable bacteria was estimated in samples exposed to the various materials for 1, 3, 6 and 24 h, respectively, and the viable counts were related to the baseline valu ...	1995	8747674