Publications

brucella abortus in fresh cream and cream products.		1968	4297595
[nucleic acid metabolism of rat spleen during synthesis of antibodies against brucella abortus].		1968	4387857
[influence of endoxan (cyclophosphamide) and 6-mercaptopurine on nucleic acid metabolism of rat spleen during synthesis of antibodies against brucella abortus].		1968	4387858
lymphoepithelial tissues of the intestine and differentiation of antibody production.	the antibody response of young rabbits to the injection of killed brucella abortus was abolished by prior extirpation of intestinal lymphoepithelial tissues combined with lethal xirradiation and reconstitution with rabbit fetal liver cells. extirpative surgery alone, like lethal x-irradiation and reconstitution without surgery, did not abolish this response. intestinal lymphoepithelial tissues of rabbits apparently play a central lymphoid function and are responsible for the differentiation of t ...	1968	4173040
antibody and immunoglobulin production at the cellular level in bursectomized-irradiated chickens.	the effect of bursectomy combined with sublethal x-irradiation in the newly hatched chicken on the immunoglobulin and antibody producing capacity in later life was investigated. the previous findings of a significant incidence of hypogammaglobulinemia in such animals were confirmed. spleen cells from severely hypogammaglobulinemic animals synthesized and secreted little or no immunoglobulin. such spleen lymphoid cells contained fewer immunoglobulin antigenic determinants than spleen cells from i ...	1969	4181832
a preliminary study of the development of 19s and 7s immunoglobulins in sera of two sheep vaccinated with brucella abortus, strain 19.	the pattern of antibody response to vaccination with brucella abortus, strain 19, was studied in two sheep. agglutinative activity was detected by the third and fifth days and complement - fixing activity by the fifth and seventh days post-vaccination. density gradient centrifugation and deae cellulose column chromatography showed the 19s antibody developed first, followed soon after by 7s antibody. the former had disappeared by the 25th day but the latter persisted longer in both sheep. a small ...	1969	4237299
fate of brucella abortus in neonatally thymectomized rats.		1969	4976513
antibody response to brucella abortus.		1969	4977407
on the fatty acids of brucella abortus and brucella melitensis.		1969	4978225
the chemical basis of the virulence of brucella abortus. ix. the increased immunogenicity of br. abortus grown in media which enhance its ability for survival within bovine phagocytes.		1969	4978351
abortion in sheep associated with brucella abortus infection.		1969	4978562
the second international standard for anti-brucella abortus serum.	in 1965, the who expert committee on biological standardization (1966) noted that stocks of the international standard for anti-brucella abortus serum were almost exhausted and requested the central veterinary laboratory, weybridge, england, to examine a quantity of serum offered by that laboratory for its suitability to serve as a replacement, and to arrange a collaborative assay. after being distributed into ampoules and freeze-dried, the serum was assayed against the international standard by ...	1969	4978932
distribution of chromate-labeled brucella abortus endoxin in tolerant mice.	endotoxin tolerance as manifested by a lesser degree of hypoferremia was demonstrated in mice when both pretreatment (10 mug per injection) and challenge (100 mug) does of brucella abortus endotoxin were administered intraperitoneally. qualitative and quantitative studies on the distribution of chromate-labeled endotoxin in normal mice revealed that the endotoxin localized predominately in the liver and hypoferremia could be related to a high uptake of endotoxin by this organ. in tolerant mice, ...	1969	4974396
[the "free" lipids of brucella abortus bang. concerning the neutral lipids].		1969	4979663
ultrastructure of brucella abortus l-forms induced by penicillin in a liquid and in a semisolid medium.	brucella abortus l-forms were induced by 5.0 or 10.0 mug of penicillin/ml in a broth medium containing 0.3 m sucrose, and in a semisolid medium containing 10% calf serum and 20.0, 40.0, or 60.0 mug of penicillin/ml. after 96 hr of incubation, l-forms of various sizes and shapes were observed. basic structures of the l-forms were similar whether induced in liquid or semisolid medium. l-forms had two "unit" membranes, each consisting of two outer dense layers separated by a lucent layer. a few lar ...	1969	4980069
the isolation of brucella abortus from a waterbuck (kobus ellipsiprymnus).		1969	4980299
increased host resistance to infection elicited by lipopolysaccharides from brucella abortus.		1969	4980494
[interferences by coxiella burneti infection in the mouse with non-specific resistance or immunity against the brucella abortus test].		1969	4982515
[demonstration of a compound of acid nature bearing antigenic specificity in brucella abortus in the smooth and rough phases].		1969	4983505
studies of experimental brucellosis. brucella abortus infection in the male guinea pig and effect of sensitization on various organs.		1969	4983853
[a case of canine brucellosis due to brucella abortus].		1969	4985208
[phenotypic variation of the morphology of brucella abortus colonies].		1969	4984757
use of mitomycin c to distinguish brucella abortus field strains from the vaccinal brucella abortus strain 19.	field strains of brucella abortus were resistant to mitomycin c, whereas strain 19 was sensitive; therefore, the antibiotic was used to distinguish b. abortus strain 19 from other strains.	1969	4984768
experimental study on the protective antigen derived from the vaccine strain brucella abortus ba-19.		1969	4985512
[isolation of brucella abortus from the organs of mink].		1969	4985671
persistence of brucella abortus, strain 19 infection in immunized cattle.		1969	4993565
isolation of brucella abortus from vaginal mucus samples.		1969	4989379
antibody elicited by brucella abortus antigen in vitro: prolonged production by cell suspensions.		1969	5765459
antigenic relationship of brucella ovis to brucella abortus and brucella melitensis using the complement fixation test.		1969	5005098
[experimental brucellosis in cattle. ii. distribution of brucella abortus 6 weeks after parturition and 3 to 5 and one-half months after experimental infection].		1970	5003298
[experimental bovine brucellosis. 3. the vaginal excretion of brucella abortus before and after parturition].		1970	5003299
illness following accidental self-inoculation of brucella abortus strain 19 vaccine.		1970	4991107
immuno-electrophoretic characterization of brucella abortus antigenic strain 99. ii. chemical extracts.		1970	4991969
reversion of rough (r) to smooth (s) forms in brucella abortus. ii. comparison of the sii form obtained after reversion with the initial si form, as well as ri and rii rough variants.		1970	4992358
differentiation of the serologicl response to yersinia enterocolitica and brucella abortus in cattle.	the serological responses of cattle to inoculation with brucella abortus and yersinia enterocolitica type ix were compared. complete cross-reactions were found in serum agglutination, antiglobulin, complement fixation and rose bengal plate tests. the cross-reaction between br. abortus and y. enterocolitica ix was confirmed by immunodiffusion tests. although antibodies specific for each organism could also be detected by immunodiffusion tests with high titre rabbit or bovine sera, these tests wer ...	1970	4992575
sero-chemical characterization of a soluble antigen extracted from brucella abortus.		1970	4993699
[studies on the complement fixation test in brucellosis. iv. correlation between titers by agglutination and by complement fixation determined with brucella abortus antigens in human and inoculated rabbits' sera].		1970	4999678
transfer of antibody production with cells from bursa of fabricius.	f(1) hybrid chicks isogenic for the strong b histocompatibility locus and for most weak h-loci were x-irradiated on day 1 after hatching, injected intraperitoneally on day 2 with dispersed cells of bursa, spleen, or thymus from 4- or 10-wk-old f(1) hybrid donors, and immediately challenged by the same route with either brucella abortus, sheep erythrocytes, or a mixture of both together. the agglutinin titers were measured in sera obtained 1 wk later. with 4-wk-old donors, a greater primary respo ...	1970	4994444
the proliferative and anamnestic antibody response of rabbit lymphoid cells in vitro. ii. requirement for adherent and nonadherent cells of the responses to particulate antigens in spleen cell cultures.	both primary and secondary responses to sheep erythrocytes and to brucella abortus antigen have been obtained in cultures of dispersed rabbit spleen cells. removal of adherent cells by repeated incubation of spleen cells on absorbent cotton diminished the ability of the spleen cell suspensions to give secondary as well as primary responses in vitro. when comparing cultures made in dishes and in tubes, the loss of responsiveness after incubation on cotton was much more evident in the dish culture ...	1970	4986217
trimethoprim-sulphamethoxazole in enteric fevers.	clinical improvement was rapid in all 13 patients with enteric fever and one with brucella abortus infection treated with trimethoprim-sulphamethoxazole. there were no side-effects of the treatment and it was found easy to administer to toxic and delirious patients.	1970	4989044
agglutinin response of rabbits to combined pasteurella tularensis-brucella abortus vaccination.	a schedule was developed for the simultaneous production of a pasteurella tularensis-brucella abortus antiserum in rabbits. three doses of 10(8) viable p. tularensis lvs organisms were given intravenously at weekly intervals. one day prior to the final dose of p. tularensis, the rabbits received 10(9) viable cells of b. abortus strain 19 intravenously. the use of live vaccines, administered in this sequence, resulted in high agglutinin titers within 3 weeks. the maximal agglutinin titer to eithe ...	1970	4985429
endotoxin-containing preparations of brucella abortus: chemical studies.		1970	4984309
endotoxin-containing preparations of brucella abortus: biological studies.		1970	4984310
[brucellosis caused by brucella abortus in humans in france. a survey at indre-et-loire].		1970	4316963
[ratio of serum antibodies in the immune response to brucella abortus].		1970	4191371
reversion of rough (r) to smooth (s) forms in brucella abortus. i. the manner of manifestation of r-s reversion.		1970	4099090
some structural and biological properties of brucella endotoxin.	hot phenol-water extraction of smooth brucella abortus and b. melitensis cells yielded a toxic fraction which was recovered from the phenol phase (fraction 5). chemically, fractions 5 from both brucella species were lipid-carbohydrate-protein-2 keto-3-deoxyoctulosonic acid complexes which were stable to heat and resistant to pronase digestion. electron micrographs of the brucella toxins were morphologically indistinguishable from those of enterobacterial endotoxins. biologically, brucella toxins ...	1970	16557710
comparison of chemical components of cell walls of brucella abortus strains of low and high virulence.	amino acid, carbohydrate, and lipid components of cell walls of brucella abortus strain 19a (low virulence) and strain 2308 (high virulence) were compared by thin layer chromatography (tlc) and by use of an amino acid analyzer. a total of 15 amino acids were detected by both chromatographic methods. each amino acid was present in greater amounts in strain 2308 than in strain 19a when equal amounts of hydrolysates of cell wall and endotoxin-containing preparations were analyzed. a component with ...	1970	16557825
interferon induction and resistance to virus infection in mice infected with brucella abortus.	induction of circulating interferon and protection against vaccinia virus infection in mice by injection of brucella abortus were studied. it was demonstrated that morphologically intact brucellae (either live or killed by heat or exposure to naoh) induce high and prolonged levels of circulating interferon in mice. in each instance, the inducing principle remained associated with the bacterial particle. disruption of brucellae by mechanical means destroyed the interferon-inducing capacity. howev ...	1970	16557902
blocking serum lysis of brucella abortus by hyperimmune rabbit immunoglubulin a.		1971	4103920
the hygiene and marketing of fresh cream as assessed by the methylene blue test. a report by a working party to the director of the public health laboratory service.	the hygiene and marketing of fresh cream in england and wales was investigated by a working party of the public health laboratory service (phls) between 1 october 1968 and 31 july 1969. thirty-one cream-producing dairies were visited and observations made in the light of the code of practice published by the milk and milk products technical advisory committee of the ministry of agriculture, fisheries and food, and the scottish home and health department. suggestions are made in this report to st ...	1971	4326247
[neutral lipids of brucella abortus].		1971	4329697
[comparative chemical studies on the polysaccharide component of the somatic antigens of brucella abortus s19 and brucella melitensis 16m].		1971	4400726
specific secondary biological properties of purified rabbit immunoglobulin m and immunoglobulin g antibodies to brucella abortus and bordetella pertussis.	rabbit immunoglobulin (ig)m and igg antibodies to brucella abortus and bordetella pertussis were isolated as purified products and their specific secondary biological activities were compared. igm antibodies were found to be more active than igg proteins in inducing agglutination and sensitization of b. abortus for the complement-dependent bactericidal effect and in inhibiting b. pertussis-induced lymphocytosis in the mouse. igm and igg antibodies were found to be equally effective in inducing a ...	1971	4343404
[immunostimulating effect of an imidotiiazole in the immunization of mice against brucella abortus infection].		1971	4995369
the use of various extracts of brucella abortus for haemagglutination test in brucellosis.		1971	4998500
a purified killed brucella abortus vaccine.		1971	4998841
immunisation of laboratory animals and cattle with non-agglutinogenic extracts of brucella abortus strain 45-20.		1971	4998854
electron microscopy of tissue culture cells infected with brucella abortus.	thin sections of hamster kidney tissue cultures were examined by electron microscopy over a 7-day period after infection with brucella abortus 3183. numerous bacteria and structures resembling l-forms were present both intracellularly and extracellularly after the first 24 hr of infection. most intracellular microorganisms were enclosed by a cytoplasmic membrane, but in a few instances no limiting membrane was detected. after 4 to 7 days, fewer microorganisms were present, and most normal-appear ...	1971	5001204
microagglutination procedures for febrile agglutination tests.	febrile agglutination tests were done by using as antigens brucella abortus, salmonella group d, proteus ox19, and pasteurella tularensis. comparison of results from 23 sera showed that the microtechnique, rapid slide, and test tube methods gave similar titers, although those from the microtechnique were generally higher. the sensitivity of the microtechnique depended upon the concentration of antigen, and, to obtain reproducible results, the optimal concentration of antigens had to be determine ...	1971	5002142
the occurrence of agglutinating, complement-fixing, and incomplete antibodies to brucella abortus in milk, and their relationship to the milk ring test.		1971	4993976
antibody response, delayed hypersensitivity, and immunity in guinea pigs induced by smooth and rough strains of brucella abortus.		1971	5004116
[lysogenic variations of brucella abortus. ii. variations obtained in vitro].		1971	5005071
[vaccination of cows with live dessau brucella abortus vaccine].		1971	5104381
recall of acquired cellular resistance in mice by antigens from killed brucella.	mice infected with brucella abortus 19 were challenged intravenously with listeria monocytogenes. spleen assays to determine the number of viable listeria cells present revealed that these mice were highly resistant to listeria when challenged on day 17 of the brucella infection. resistance was absent in mice challenged on the 5th day and was declining in mice challenged on the 33rd day. resistance could not be detected by day 49 of the brucella infection but could be recalled by the injection o ...	1972	4632467
the use of brucella abortus 45-20 adjuvant vaccine as a diagnostic aid in the brucellosis eradication campaign in papua new guinea.		1972	4651121
ontogeny of bursal function in chicken. 3. immunocompletent cell for humoral immunity.	to study the occurrence of immunocompetent cells directly responsible for antibody production, cells from yolk sac, embryonic liver, bursa of fabricius, bone marrow, spleen, or thymus were injected together with srbc and brucella abortus into 4-day old cyclophosphamide-treated chicks. a second stimulation was given 4 days later, and samples taken 4 days thereafter were used for antibody titrations. during ontogeny, immunocompetent cells appeared in significant numbers first in the spleen for ant ...	1972	4403475
interferon production linked to toxicity of polyriboinosinic acid-polyribocytidylic acid.	different procedures have been used in attempts to increase the production of interferon by polyriboinosinic acid-polyribocytidylic acid (poly [ri].poly [rc]) in mice: simultaneous injection of lead acetate, cycloheximide, or actinomycin d and prior injection of freund's adjuvant, chlorite-oxidized oxyamylose (coam), endotoxin, or brucella abortus. in the experimental conditions tested, lead acetate, cycloheximide, freund's adjuvant, and coam brought about a parallel increase in interferon produ ...	1972	4564891
characterization of brucella abortus strain 19.		1972	4622856
brucella abortus recovery from milk samples.		1972	4623756
subclinical brucella infection in man.	much subclinical infection with brucella abortus affects the dairy farming community, slaughterhouse workers, and veterinary surgeons. high titres of antibody to b. abortus by the saline agglutination, antihuman globulin, or complement fixation test may be shown in subjects from the first two groups and generally there are no symptoms or signs of brucella infection whatever. veterinary surgeons are prone to subclinical infection and young practitioners frequently display high titres against the ...	1972	4625113
the use of laboratory animals in the potency test of brucella abortus s.19 vaccine. response of guinea-pigs to graduated doses of vaccine and challenge.		1972	4625200
brucella melitensis rev. 1 and brucella abortus 45-20 vaccines in goats: immunity.		1972	4626469
the mechanism of immunostimulation induced by inactivated brucella abortus.		1972	4626522
the effect of passively acquired antibodies to brucella abortus on the immune response to strain 19 vaccine.		1972	4627403
the immunization of guinea-pigs and mice with a whole-culture extract of a smooth and a rough strain of brucella abortus.		1972	4628447
the chemical basis of the virulence of brucella abortus. x. a surface virulence factor which facilitates intracellular growth of brucella abortus in bovine phagocytes.		1972	4630410
a case of abortion consequent upon infection with brucella abortus biotype 2.	the case described here is that of young primigravida in normal health who, on serological evidence, contracted acute brucellosis, and subsequently aborted spontaneously, br. abortus biotype 2 being isolated from the amniotic fluid.	1972	4630417
mechanism of resistance to virus challenge in mice infected with brucella abortus.		1972	4343370
the relationship of brucella abortus agglutinogenic antigens to the receptor sites for tbilisi phage.		1972	4111734
[on the bactericidal power of samples of human blood against strains of brucella melitensis and brucella abortus].		1972	4205694
[lysogenic variants of brucella abortus. 3. a study of the allergic reaction in experimentally infected laboratory animals].		1972	4197603
a serological investigation on adult cattle vaccinated with brucella abortus strain 19.		1973	4197922
abortion associated with brucella abortus (biotype 1) in the t.b. mare.		1973	4198441
serological cross-reactions between different brucella species and yersinia enterocolitica. biological and chemical investigations of lipopolysaccharides from brucella abortus and yersinia enterocolitica type ix.		1973	4199585
the survival of brucella abortus in milk and milk products.		1973	4200287
stimulation of anti-brucella vaccination in mice by tetramisole, a phenyl-imidothiazole salt.	the effect of tetramisole (hydrochloride of racemic 2, 3, 5, 6,-tetrahydro-6-phenyl-imidazo [2, 1-b] thiazole) on immunization was investigated in mice vaccinated by killed brucella melitensis cells suspended in incomplete adjuvant. immunity to brucella abortus challenge was estimated by the reduction in number of b. abortus colonies per gram of spleen in those mice which escaped full immunization and also by calculation of mean infective doses for each group of mice. all tetramisole treatments ...	1973	4200541
immune response to a syngeneic rat tumour: evolution of serum cytotoxicity and blockade.		1973	4202457
the immuno-diffusion method for the identification of cattle vaccinated with brucella abortus strain 45-20.		1973	4202541
the sensitivity of brucella abortus to chemotherapeutic agents.		1973	4202898
assessment of fluorescent antibody absorption procedures for differentiation of the serological response to yersinia enterocolitica serotype ix and brucella abortus in cattle.		1973	4203694
the incidence of the various biotypes of brucella abortus in cattle in the south-west of scotland.		1973	4204008
[increase in the immunostimulation properties of inactivated brucella abortus b 19 by simultaneous use of a specific immune serum].		1973	4197497
the direct fluorescent antibody test for detection of brucella abortus in bovine abortion material.	the direct fluorescent antibody test was assessed for detection of brucella abortus in bovine abortion material. br. abortus organisms could be readily detected as characteristic intra-cellular clumps, in smears stained with fluorescent antibody. counterstaining with evans blue was necessary to suppress tissue auto-fluorescence. the method was specific and enabled brucella infection to be differentiated, inter alia, from q-fever infection.	1973	4121013
serological cross-reactions between different brucella species and yersinia enterocolitica. immunochemical studies on phenol-water extracted lipopolysaccharides from brucella abortus and yersinia enterocolitica type ix.		1973	4125692
serological cross-reactions between different brucella species and yersinia enterocolitica. agglutinating activity of 19 s and 7 s antibodies aginst somatic antigen of brucella abortus and yersinia enterocolitica type ix.		1973	4128117
evaluation of various media and the use of soil infusion in the production of brucella abortus antigen.	brucella abortus (adri 413) was grown on various synthetic, commercial, laboratory-formulated and soil infusion-supplemented agar media. of 22 media tested, three soil infusion-supplemented media and a serum dextrose agar yielded more brucella antigen than the meat infusion agar, the standard reference medium. results from agglutination and stability tests indicated that antigens produced from most of the laboratory-formulated media and the soil infusion-supplemented agars compared favourably wi ...	1973	4265551
the utilization of brucella abortus culturing and biotyping results in the epizootiologic investigation of bovine brucellosis.		1973	4283853
[greater attenuation of the virulence of brucella abortus 19 with preservation of its immunogenicity].		1973	4208623
the rose bengal plate agglutination test in dairy cattle in zambia vaccinated over age with strain 19 brucella abortus.		1973	4213481