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helicobacter pylori: histological and serological study on gastric and duodenal ulcer patients in estonia.we have examined the occurrence of helicobacter pylori (hp) infection in 86 estonian gastric ulcer (gu) and 25 duodenal ulcer (du) patients. diagnosis of the hp infection was made histologically (modified giemsa) from gastric biopsy specimens, and serologically by parallel use of two enzyme-linked immunosorbent assays for igg antibodies to hp in patient sera. the infection was diagnosed simultaneously by all three methods in 84% of the gu and 84% of the du patients. the infection was revealed hi ...19911759135
helicobacter pylori and gastritis in children with abdominal complaints.gastroscopy with biopsies was performed in 178 children with upper abdominal pain. of them 109 (61%) had gastritis and 104 (58%) helicobacter pylori (hp) in antrum and/or corpus. gastritis consisted in most cases (87% of antral and 86% of corpus gastritis) of mild superficial round cell infiltration. mucosal atrophy was not found. accumulation of granulocytes was present in 43 patients and lymphonoduli were found in 33 patients, usually in connection with gastritis. gastritis affected only the a ...19911759137
[gastritis and campylobacter pylori. 85 cases]. 19911759317
omeprazole in short-term treatment of helicobacter pylori positive duodenal ulcer. 19911760568
[helicobacter pylori colonization in surgical patients].the prevalence of helicobacter pylori (hp) was examined in 387 patients undergoing endoscopy of the upper gastrointestinal tract. of central interest was the question to which extent surgical intervention influences the colonisation of the gastric mucosa with hp. the bacillic status was appraised using double microbiological examinations, histological determination and the clo-test. in 229 patients a 13c-urea-breath test was also carried out (sensitivity 98%). hp could be detected in 90% of all ...19911760952
characterization of an immunoreactive species-specific 19-kilodalton outer membrane protein from helicobacter pylori by using a monoclonal antibody.immunoblotting experiments on hyperimmune rabbit serum and sera from patients with helicobacter pylori gastritis showed a consistent antibody response to a 19-kda outer membrane protein antigen. a monoclonal antibody, designated hp 40, which reacted by western immunoblotting with this protein was produced. it was shared by all h. pylori strains tested (d 273, nctc 11637, and 24 wild strains) but not by the thermophilic campylobacter species, campylobacter fetus, helicobacter mustellae, or helico ...19911761682
serodiagnosis of helicobacter pylori: comparison of enzyme-linked immunosorbent assays.enzyme-linked immunosorbent assays (elisas) have been developed to diagnose helicobacter pylori infection. however, the methods are not standardized. we therefore prospectively evaluated the sensitivities and specificities of elisas developed in the united states and the united kingdom in a study population comprising 41 consecutive symptomatic outpatients and 35 volunteers. at endoscopy, multiple biopsies were obtained for histology and culture and stained sections were graded for chronic gastr ...19911761685
indirect immunofluorescence assay for detection of helicobacter pylori in human gastric mucosal biopsies.to determine sensitivity and specificity of immunofluorescence assay (ifa) for detection of helicobacter pylori, we studied 151 patients. biopsies of gastric mucosae were obtained for culture, histological testing, and ifa. h. pylori serum antibodies were tested by enzyme-linked immunosorbent assay. ifa was done on formalin-preserved, paraffin-embedded biopsies by using rabbit anti-h. pylori and goat anti-rabbit gamma globulin-fluorescein isothiocyanate conjugate. the sensitivity and specificity ...19911761700
effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa.the effect of alterations in the biliary tract on the gastric milieu was evaluated in gallstone disease and after cholecystectomy or biliary fenestration and compared with a control group. endoscopic bile reflux was often found in gallstone patients (67%) and almost always after cholecystectomy (89%). gastric bile acid concentrations were greater in the gallstone patients than in the control patients, were higher still after cholecystectomy, and were highest after biliary fenestration. the ph of ...19911763297
[helicobacter pylori: can it be a contributing factor in peptic ulcer in childhood?].helicobacter pylori is a recently identified microorganisms which is thought to be the causing agent of the peptic acid disease in children as well as in adults. it is currently accepted that frequent relapses of this illness in spite of an adequate treatment can be associated to the faulty eradication of this bacteria. this article outlines the characteristics of h. pylori, its incidence, pathogenesis, as well as the current diagnostic methods used and the treatment applied.19911764199
gastroenterological emergencies in the tropics.significant differences exist in the prevalence of most gastroenterological emergencies in tropical compared with temperate countries. both ethnic and environmental (often clearly defined geographically) factors are relevant. the major oesophageal lesions which can present acutely in tropical countries are varices and carcinoma; bleeding and obstruction are important sequelae. peptic ulcer disease (and its complications), often associated (not necessarily causally) with helicobacter pylori infec ...19911764626
the epidemiology of helicobacter pylori infection.the evidence that h. pylori causes gastritis in humans comes from both primary and secondary observations. the most important primary observations are the human volunteer studies, the animal models, and the treatment studies with antimicrobial agents. supporting information comes from studies showing the specific association of h. pylori infection with type b gastritis and with gastric (but not intestinal) epithelial cells; the specific ultrastructural lesions, including adherence pedestals; the ...19911765119
[relationship between helicobacter pylori and antral gastritis and gastroduodenitis].morphological data on the biopsies obtained from the antral gastric mucosa of 150 chronic gastritis and gastroduodenitis patients provided grounds for recognition of 3 degrees of gastritis activity. helicobacter pylori (cp) occurred in the antral gastric portion in 100% of the cases. cp presence and mucosa contamination, plasmocytic infiltration, dystrophic changes in the surface and glandular epithelium were found to correlate. administration of ampiox in a daily dose of 1.0 g for 10 days resul ...19911766223
prevalence of helicobacter pylori in patients with end-stage renal failure and renal transplant recipients.the prevalence of helicobacter pylori was determined using an elisa technique for igg antibodies to h. pylori in 76 patients with end-stage renal failure who were receiving regular haemodialysis and 202 patients with functioning renal transplants. twenty-seven (34%) of the haemodialysis group and 58 (29%) of the transplant group were positive for h. pylori igg antibodies, and the prevalence did not differ significantly from that in 247 age-matched healthy controls. in the haemodialysis group, pa ...19911766499
[significance of campylobacter pylori in the surgical treatment of stomach and duodenal ulcer]. 19911767324
[chronic primary gastroduodenitis and helicobacter pylori--their relationship]. 19911767327
[helicobacter (campylobacter) pylori in stomach and duodenal biopsies].in bioptic specimens of the gastric mucosa of 57 patients with dyspeptic complaints and/or a duodenal ulcer helicobacter pylori was detected under the microscope in 82,4% of chronic active gastritis and in 28,6% and 61,5% resp. of chronic gastritis grade i and ii. the finding of helicobacteria depended on the number of collected specimens. they were never found at sites with intestinal metaplasia and their numbers did not correspond to the intensity and character of the inflammatory changes. as ...19911769044
the role of helicobacter pylori in gastroduodenal disease.peptic ulcers are the result of a wide variety of factors, with h. pylori probably being one of the more significant. h. pylori has been most strongly associated with gastritis and duodenal ulcer disease. the relationship of h. pylori to gastric ulcers is less substantial. the eradication of h. pylori can be achieved in the majority of patients with triple antibiotic therapy. however, resistance to metronidazole occurs readily. eradication of h. pylori can change the course of duodenal ulcer dis ...19911769198
[helicobacter pylori and duodenal ulcer. long-term results of triple sucralfate antibiotic therapy]. 19911769484
helicobacter pylori infection: a novel risk factor in the etiology of gastric cancer. 19911770545
gastric adenocarcinoma and helicobacter pylori infection.helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. to determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or ...19911770552
[chronic active surface-positive campylobacter antrum gastritis-- morphological changes 1 year after treatment with bismuth].the works is based on a previous investigation published in the journal vnitrní lékarství, 36, 1990, 8, pp. 759-762. the authors investigated morphological changes of the gastric mucosa and the presence of campylobacter pylori (cp) in probands with chronic active surface cp positive antrum gastritis one year after treatment with a bismuth preparation (bismuth citrate 120 mg per capsule made on prescription) for a one-month period 4 capsules per day. this concerned probands with functional dyspep ...19911771809
[helicobacter pylori after proximal selective vagotomy].the authors examined histologically in 40 patients after proximal selective vagotomy on account of duodenal ulceration specimens of the antral mucosa for the presence of helicobacter pylori. the latter was detected in 38 (95%) patients. the intensity of colonization evaluated semiquantitatively was not directly related to the dyspeptic complaints. no relapses of ulcers were observed and the author's experience does not confirm the theory of a direct part played by helicobacter in the manifestati ...19911771810
[the treatment of patients with chronic gastritis]. 19911771849
[helicobacter pylori colonization of the gastric mucosa in rheumatic patients].this study examines whether infections with helicobacter pylori are more frequent in patients suffering from rheumatoid arthritis than in patients with non-inflammatory rheumatic diseases. the study furthermore examines whether the colonisation by h. pylori is favoured by antiphlogistic-antirheumatic treatment. for this purpose gastric biopsies obtained by endoscopy from 123 patients were histologically evaluated for the presence of h. pylori. 85 patients with rheumatoid arthritis were compared ...19911771932
the simplified 13c-urea breath test--one point analysis for detection of helicobacter pylori infection.a 13c-urea breath test for detection of helicobacter pylori infection was validated in 306 patients. breath samples (four, two or one) were taken at various time points within 30 minutes after a motility inhibiting liquid test meal with citric acid followed by 75 mg of 13c-urea. the 13co2/12 co2-ratio (delta-value) was measured using isotope ratio mass spectrometry and the recovery of tracer in the exhaled breath was calculated (ubt-value). in 172 patients a comparison of established reference m ...19911771933
the role of omeprazole (40 mg) in the treatment of gastric helicobacter pylori infection.the efficacy of omeprazole in the elimination of helicobacter pylori was investigated in a prospective randomized-controlled trial. 50 patients with upper gastrointestinal symptoms and chronic active h. pylori-associated gastritis were allocated to one of the following four therapeutic schedules: 1) omeprazole 40 mg/d for 4 weeks (n = 13); 2) bismuth subsalicylate (bss) 3 x 600 mg for 4 weeks (n = 12); 3) omeprazole plus bss for 4 weeks (n = 13); 4) triple therapy (bss for 4 weeks, amoxicillin 3 ...19911771934
[the contribution of endoscopy in the diagnosis of esophago-gastro-duodenal disorders in a tropical milieu. experience in benin with 930 examinations].the authors analyse the results of esophago-gastro-duodenal fibroscopy in 930 symptomatic patients. ninety one per cent of them had lesions. inflammatory pathology was predominant: esophagitis, gastritis and duodenitis were seen in 21.5%, 47% and 29.08% respectively of the patients investigated. gastritis accompanied 75.13% of cases of esophagitis and 76.4% of duodenitis, and was associated with the demonstration of the presence of helicobater pylori in gastric biopsies in 56.41% of patients wit ...19911772237
simplified single sample 13carbon urea breath test for helicobacter pylori: comparison with histology, culture, and elisa serology.there is no ideal method for detecting helicobacter pylori. the 'standard' 13carbon urea breath test (13c-ubt), which involves collecting eight to 15 breath samples and subsequent costly analysis, was modified by pooling 21 samples of expired breath taken at five minute intervals for 40 minutes into a collecting bag, from which a single 20 ml aliquot was taken and analysed by mass spectrometry. this test was evaluated on 50 patients after routine upper gastrointestinal endoscopy, and results wer ...19911773948
mucosal tumour necrosis factor alpha and interleukin-6 in patients with helicobacter pylori associated gastritis.the production of tumour necrosis factor alpha (tnf alpha) and interleukin-6 by human antral mucosa during short term culture in vitro has been measured by enzyme linked immunosorbent assay. tnf alpha and interleukin-6 concentrations in culture supernatants were significantly greater (p less than 0.001) in patients infected with helicobacter pylori, all of whom had chronic gastritis, than in patients who were h pylori negative with histologically normal gastric mucosa. among h pylori colonised p ...19911773951
comparative evaluation of three selective media and a nonselective medium for the culture of helicobacter pylori from gastric biopsies.plating on solid media is the standard technique used in most laboratories for the isolation of helicobacter pylori from gastric biopsies. recently, various selective media were developed for this purpose. we compared and evaluated three selective media, skirrow's, dent's cp, and modified glupczynski's brussels campylobacter charcoal media, and chocolate agar medium for the isolation of h. pylori. gastric biopsies taken from a total of 203 patients were plated in parallel on all four media. an i ...19911774265
reproducibility of tolerance tests that are useful in the identification of campylobacteria.twenty type or other reference strains, each representing a different campylobacter, helicobacter, or arcobacter taxon, were used to assess the reproducibility of 25 phenotypic tests that are used in the identification of such organisms. twenty-two of the tests depended on growth inhibition, and each of these tolerance tests was performed by using three different basal media. although the overall reproducibility of the tests with each basal medium exceeded 89%, the proportion of strains that wer ...19911774297
evaluation of the e test for quantitative antimicrobial susceptibility testing of helicobacter pylori.the progressive diagnostics manufacturers epsilometer test (e test; ab biodisk, solna, sweden), a quantitative variant of the disk diffusion technique, was evaluated comparatively to an agar dilution method for the antimicrobial susceptibility testing of helicobacter pylori. a collection of 79 h. pylori clinical strains, including isolates with known resistance to various antimicrobial agents, was tested against 12 different antimicrobial agents. all strains were tested on columbia agar suppleme ...19911774337
incidence of campylobacter pylori in a consecutive series of surgical patients referred for endoscopy. 19911774718
helicobacter pylori: a jordanian study.the prevalence of helicobacter pylori in patients with upper gastrointestinal symptoms in the north of jordan was studied prospectively. the occurrence of h. pylori was documented histologically and bacteriologically in 169 patients attending endoscopy for upper gastrointestinal symptoms. our results showed that h. pylori was present in 70% of patients with acute gastritis, 73% of patients with chronic gastritis, 68% of patients with acute on chronic gastritis, 83% of patients with duodenal ulce ...19911775426
helicobacter pylori.helicobacter pylori is a unique pathogen and the leading cause of chronic gastric inflammation. for many individuals the organism is of low virulence, causing only mild inflammation and generating few, if any, dyspeptic symptoms. for those with more severe inflammation, h. pylori infection may be causal in the generation of dyspeptic symptoms. h. pylori infection appears to be the dominant factor in peptic ulcer disease. events considered to be of importance are a disturbed gastrin homeostasis a ...19911775918
mechnisms of injury and sequelae of helicobacter pylori infection. concluding commentary--the basic scientist's viewpoint. 19911775919
mechanisms of injury and sequelae of helicobacter pylori infection. concluding commentary--the gastroenterologist's viewpoint. 19911775920
helicobacter pylori infection and inflammation.helicobacter pylori infection and chronic active gastritis are inextricably linked, and this organism is almost certainly responsible for inducing the resulting inflammatory changes. acute ingestion studies have confirmed that h. pylori infection causes acute gastritis, and the progression to chronic gastritis has been documented. duodenitis and h. pylori infection often occur concurrently, but colonization is restricted to those with significant gastric metaplasia. the association between h. py ...19911775921
virulence factors of helicobacter pylori.helicobacter pylori can be considered a very successful organism effectively colonizing the majority of the world's population. although various disease states associated with this infection have been described, the mechanisms of pathogenicity remain unknown. the easiest virulence factors to identify are those enabling the organism to colonize the hazardous microenvironment of the gastric epithelium, survive at this site, and multiply sufficiently for transmission to a new host. the factors iden ...19911775922
helicobacter pylori urease: properties and role in pathogenesis.urease (urea amidohydrolase, ec 3.5.1.5) catalyzes the hydrolysis of urea to yield ammonia and carbon dioxide. research on this enzyme has gained momentum since the discovery of helicobacter pylori as a causative agent of human gastritis. the remarkably high urease activity of each organism has served as the basis of diagnostic tests for the presence of the organism in the urease biopsy test and urea breath test. urease undoubtedly plays a central role in h. pylori pathogenesis. hydrolysis of ur ...19911775923
mucolytic effects of helicobacter pylori.the mechanisms associated with colonization of human gastroduodenal mucosa by helicobacter pylori remain unclear. to colonize gastric-type epithelium h. pylori must enter the gastric lumen, resist damage by all bactericidal factors operating within the acidic gastric milieu, penetrate the mucus gel despite highly viscous and hydrophobic properties of the mucus layer, and, finally, secure optimal conditions for its further multiplication. since the h. pylori microorganism has been seen freely spr ...19911775924
interactions between helicobacter pylori and the local mucosal immune system.the recognition that helicobacter pylori is associated with an array of gastric disorders immediately raises several issues with regard to the role of the local immune system. the belief that the harsh gastric environment limits or prevents infection has perhaps dismissed studies into the immunology of the stomach as a low priority. now, in combination with our understanding of local immune reactivity in pernicious anaemia, an interest in defining the contribution of the immune response in the p ...19911775925
possible mechanisms and mediators of gastritis associated with helicobacter pylori infection.there is a growing body of evidence suggesting that helicobacter pylori plays a pathogenic role in gastric and duodenal ulceration. a strong association between infection with this organism and the presence of active chronic gastritis in the antrum has been documented. however, the mechanism through which this gastritis and the associated degenerative changes in the mucosa are produced is not fully understood. it is possible that the bacterium itself produces chemotactic factors that recruit gra ...19911775926
helicobacter pylori and gastric acid secretion: the ulcer link?helicobacter pylori is a recognized cause of chronic active gastritis and is frequently associated with peptic ulcer disease, but its effect on acid secretion is unclear. transient hypochlorhydria occurs with acute infections. despite the theoretical possibility of an increase in parietal cell mass or a response to stimulation occurring secondary to the associated hypergastrinaemia observed with h. pylori, no consistent increase in basal, pentagastrin-stimulated acid secretion or 24-h intragastr ...19911775927
helicobacter pylori--some what, why, and how morphologic issues.this paper questions, and attempts to answer or speculate on, some of the morphologic questions about helicobacter pylori in the stomach and duodenum. these include whether h. pylori can survive intact through the entire intestine, why organisms are found between rather than over the entire cells, why pedestals are relatively infrequent, possible advantages of attachment rather than a luminal existence, the nature of the inflammatory cascade from chronic inflammation to local erosion, possible m ...19911775928
helicobacter and hypergastrinemia: the quisling option.helicobacter infection of the gastric antrum is linked to the development of duodenal ulcer. a key element could be the associated hypergastrinemia. this brief commentary seeks answers to the following questions: 1) does hypergastrinemia occur? 2) how does it occur? and 3) does it matter?19911775929
spiral organisms: what are they? a microbiologic introduction to helicobacter pylori.the stomach provides a hostile environment to most microorganisms owing to the antibacterial effect of gastric acidity. however, over the period of mammalian evolution a highly specialized group of bacteria has evolved to inhabit the gastric mucosa. the common features of these bacteria that allow survival in the stomach and colonization of their natural ecologic niche, mucus, are a specialized form of motility, microaerophilism, and very high activity of the enzyme urease. other important adapt ...19911775930
helicobacter pylori infection and gastroduodenal injury by non-steroidal anti-inflammatory drugs.helicobacter pylori infection with active gastritis is comparably common in non-steroidal anti-inflammatory drug (nsaid) users and controls. the prevalence of active acute gastritis and its severity relate to h. pylori infection and not to use or non-use of nsaids. in individual patients active gastritis may deteriorate during long-term nsaid therapy but is rare in aspirin users. among nsaid users those with h. pylori gastritis appear to have more dyspeptic symptoms, repeated intolerance to diff ...19911775931
helicobacter pylori, causation, change in natural history, and why helicobacter-positive duodenal ulcers should not be routinely treated.the relationship between helicobacter pylori and duodenal ulcer is reviewed with regard to the following epidemiologic issues: causation, change in natural history, and whether there is sufficient evidence to treat h. pylori-positive peptic ulcers routinely. there is mounting evidence for a pivotal role of h. pylori as a precipitating cause of duodenal ulcers. there is insufficient data to conclude that eradication of h. pylori alone will cure peptic ulcer disease--that is, preventing instead of ...19911775932
short report: the effect of omeprazole on helicobacter pylori and associated gastritis.twenty-one patients with endoscopically confirmed duodenal ulceration, who had failed to heal with an h2-antagonist, were given omeprazole 20 mg o.m. for four weeks. four antral biopsies from each patient were taken at endoscopy before, at the end of, and four weeks after treatment. rapid urease test, culture, histopathology and transmission electron microscopy were carried out on these biopsies to determine the presence of helicobacter pylori and improvement of gastritis. after four weeks of tr ...19911777552
from the departments of internal medicine and pathology. lsu medical center, shreveport. benign gastric ulcer and h pylori infection. 19911779188
[urease test for rapid demonstration of helicobacter pylori in biopsies from the pyloric antrum].helicobacter pylori (hp) is an important etiological factor in chronic gastritis and duodenal ulceration. demonstration of hp by means of culture and histological examination is relatively time-consuming. the object of this investigation was to assess the validity of two rapidly read chemical tests: the buffered urease reagent (br) and the unbuffered urease reagent (ubr) in demonstration of hp among patients referred for gastroscopy on account of upper abdominal dyspepsia. in 230 sets of biopsie ...19911781060
[helicobacter pylori infection and the surgically treated stomach].in 38 patients who had been operated for peptic ulcer (32) or gastric cancer (6), we performed upper gi endoscopy with biopsies. hp was found in the mucosa in 8 out of 10 patients with highly selective vagotomy, 5 out of 11 patients with gastrectomy for ulcer, 6 out of 11 patients with vagotomy-pyloroplasty and in only 1 case out of 6 with gastrectomy for cancer. these results are in agreement with other publications. bilio-pancreatic reflux into the stump probably explains why hp was found in o ...19911781613
the effect of bile acids on the growth and adherence of helicobacter pylori.bile reflux gastritis occurs in the absence of helicobacter pylori (h. pylori). the aim of this study was to see if the bile acids cheno or ursodeoxycholic acid affected the growth or adherence of h. pylori in vitro. twenty-seven strains growth were inhibited by 0.1% chenodeoxycholic acid whereas only 11 out of the 27 were inhibited by 0.1% ursodeoxycholic acid. growth was totally inhibited by a combination of 0.05% chenodeoxycholic acid +0.05% ursodeoxycholic acid. chenodeoxycholic acid was a m ...19911782308
role of mucus in gastric mucosal protection.even though there is no general agreement as to the mechanism of gastric mucosal protection, the consensus is that the initial brunt of luminal insults falls on the mucus layer which constitutes the only identifiable physical barrier between the gastric lumen and the mucosal surface. the continuous renewal and resilient nature of this layer efficiently counters peptic erosion of the gel, assures its viscoelastic and permselective properties, and provides a milieu for containment of the diffusing ...19911782415
[the "sydney system": a consensus approach to gastritis. is a new "classification" necessary?]. 19911783247
[helicobacter pylori and erosive lesions of the gastric mucosa in cirrhosis]. 19911783258
[the role of helicobacter pylori in the development of chronic gastritis and gastroduodenal ulcers].to determine the correlation between helicobacter pylori colonization of the gastric mucosa and the incidence of chronic gastritis as well as gastric and duodenal ulcer, 52 patients (26 women and 26 men) aged 19-77 years (mean 46 years) with gastrointestinal symptoms were studied. biopsy specimens for histological and bacteriological examinations were taken during upper gastrointestinal tract endoscopies. helicobacter pylori was found in 21 (40%) patients: 14 women and 7 men (p less than 0.05). ...19911784540
[clinical characteristics of gastric infection caused by helicobacter pylori].in a series of 150 patients submitted for diagnostic gastroscopy, a prospective study of nine anamnesis variables and four exploratory ones was done. endoscopic and histopathologic diagnoses, as well as the clinical data, were obtained by blinded observers. helicobacter pylory (hp) presence in antral mucosa was determined by culture. a clear relationship between hp presence and peptic ulcer disease, bulboduodenitis and histologic gastritis was found, as expected, but no clinical variable correla ...19911784797
severe helicobacter pylori infection in a patient with aids.a 30-year-old man with aids presented with symptoms of fever, epigastric pain and weight loss, together with histological findings of helicobacter pylori-induced gastritis. his symptoms resolved with treatment, as indicated by the clearing of his h. pylori infection on repeat gastric biopsy. although uncommon, h. pylori infection can cause severe illness in patients with aids.19911786152
[campylobacteriosis in clinical practice]. 19911787672
prevalence of helicobacter pylori in nonulcer dyspepsia. 19911789883
[isolation and identification of bacteria of the genera campylobacter and helicobacter]. 19911789898
characterization of a plasmid from helicobacter pylori encoding a replication protein common to plasmids in gram-positive bacteria.a 1.5 kb cryptic plasmid was isolated from helicobacter pylori. low-stringency hybridization analysis using this plasmid as a dna probe revealed base sequence homology with other plasmids in this species. nucleotide sequence analysis identified an open reading frame encoding a putative polypeptide of 25 kda. this protein showed marked amino acid sequence similarity to replication-initiation proteins commonly found in small plasmids endogenous to gram-positive bacteria which replicate by the 'rol ...19911791753
[the significance of helicobacter pylori in the pathogenesis of peptic ulcer]. 19911792762
[duodenal ulcer: long-term treatment]. 19911792843
helicobacter pylori: treatment with combinations of pivampicillin and tripotassium dicitrato bismuthate.fifty helicobacter pylori- (h. pylori) positive patients entered an open study and were assigned to one of four treatment regimens comprising: pivampicillin (500 mg b.d.) for 2 weeks +/- tripotassium dicitrato bismuthate (tablet or liquid form) for one month. the 14c-urea breath test was used to evaluate clearance (negative at the end of treatment) and eradication (negative at 1 month post-treatment) of h. pylori. clearance rates were 20% (2/10) after pivampicillin alone, 86% (12/14) after tripo ...19911793785
evaluation of a commercial latex test for serological diagnosis of helicobacter pylori infection in treated and untreated patients.the value of a commercially available latex test (pyloriset) for the diagnosis of helicobacter pylori infection by demonstration of specific antibodies was compared with that of direct diagnostic methods such as culture, biopsy-urease test and microscopy of fuchsin-stained smears. the sera were from 136 patients who prior to this study either had or had not been treated for helicobacter pylori-infection simultaneously with amoxicillin (3 x 750 mg/day) and metronidazole (3 x 500 mg/day) for 12 da ...19911794371
gastritis and helicobacter (campylobacter) pylori--merely one more piece in the jigsaw puzzle or the final answer? 19911794913
development of sustained achlorhydria in a patient with the zollinger-ellison syndrome treated with omeprazole.spontaneous remission of gastric acid hypersecretion in the zollinger-ellison syndrome occurs rarely. this study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the zollinger-ellison syndrome. reduced secretion began soon after starting treatment with omeprazole, and achlorhydria became complete 6 months later. the patient remains well with normal endoscopy results and is achlorhydric 4 years after the ...19911796940
helicobacter pylori and gastric carcinoma. 19911796961
helicobacter pylori, smoking and gastroduodenitis.there is epidemiological evidence of an association between cigarette smoking and gastritis. to find out whether the reason for this might be related to the presence of helicobacter pylori, biopsies were taken from the gastric corpus and antrum and from the duodenal bulb in 106 consecutive patients referred for oesophagogastroduodenoscopy because of epigastric pain. patients with ulcer disease or cancer were excluded. the biopsy specimens were cultured for h. pylori and examined histologically f ...19911797597
inhibition of helicobacter pylori colonization by sulfated gastric mucin.the role of human gastric mucin in mucosal protection against helicobacter pylori colonization was investigated. h. pylori cells were incubated with purified intact mucin or its acidic fractions and then examined for their inhibitory capacity of h. pylori attachment to erythrocytes. titration data established that the inhibitory activity of mucin was associated with its acidic component as the fraction enriched in sialic acid and sulfate showed 16-fold higher inhibitory titer than that of the in ...19911799374
enzyme-linked immunosorbent assay for detection of immunoglobulin g antibody against helicobacter pylori.eight strains of sonicated helicobacter pylori (h. pylori) were pooled as group antigen to detect the serum igg antibody to h. pylori in patients with various gastroduodenal diseases and subjects at health check-up. the enzyme-linked immunosorbent assay method used had a sensitivity of 94%, a specificity of 87%, and a positive predictive value of 96%. the prevalence of serum igg antibody to h. pylori was 19.0% in patients with type a gastritis, 76.0% in patients with type b gastritis, 91.5% in d ...19911800030
evaluation of culture media and antimicrobial susceptibility of helicobacter pylori.isolation of helicobacter pylori on artificial culture is hampered by the lack of reliable and cheap media. in this study, three different types of culture media were evaluated for isolation of h. pylori from clinical specimens. these media included: modified thayer-martin (mtm), skirrow's campylobacter agar and chocolate agar. modified thayer-martin agar was superior in isolation to others with an isolation rate of 47% (31/66). the size of colonies on this media were larger and clearly defined. ...19911800079
antral helicobacter pylori-like organisms in different states of gastric acid secretion.the frequency of helicobacter pylori (h.p.) infestation in antral mucosa and the presence of gastritis were investigated in different states of gastric acid secretion. biopsies were stained by the warthin-starry technique and hematoxylin-eosin. antral h.p. was found in similar frequencies in zollinger-ellison syndrome (n = 17; profound acid hypersecretion, associated with duodenal ulcer disease in most cases) and the same number of age-matched controls (35% in each group) whereas h.p. could be d ...19911800186
antibacterial activity of cefpodoxime in comparison with cefixime, cefdinir, cefetamet, ceftibuten, loracarbef, cefprozil, bay 3522, cefuroxime, cefaclor and cefadroxil.the new oral cephalosporins cefpodoxime, cefixime, cefdinir, cefetamet and ceftibuten demonstrate enhanced activity against enterobacteriaceae susceptible to the established compounds as well (e.g. cefuroxime, cefaclor, cefadroxil). in addition, cefpodoxime, cefixime, cefdinir, cefetamet and ceftibuten include in their spectrum species hitherto resistant to oral cephalosporins (proteus vulgaris, providencia spp., yersinia enterocolitica). besides, the majority of these compounds demonstrate rele ...19911800377
ulcer relapse rates following initial treatment with bismuth subnitrate as compared with cimetidine respectively.as part of an open clinical trial, 18 out of 23 (78%) patients were treated with bismuth subnitrate (3 x 700 mg/d) and 15 out of 25 (60%) patients were treated with cimetidine (1 x 800 mg/d) to cure peptic ulcers linked with h. pylori, as ascertained following an endoscopic examination. all patients underwent continued observation after complete healing on completion of four weeks of acute treatment. in order to determine the effect of the initial treatment on the rate of relapse, all patients w ...19911800390
h. pylori and gastroduodenal disease. 19911800977
[the intestinal microflora and acid-forming function of the stomach in peptic ulcer patients with helicobacter pylori bacteriosis].seventeen duodenal ulcer patients were examined. h. pylori were detected in all the patients by histological and bacteriological methods. changes in the enteric microflora, manifested by a decrease in the number of lacto- and bifidobacteria and by an increased level of opportunistic microflora, were established. cimetidine treatment and the suppression of the acid-producing function of the stomach augmented enteric dysbacteriosis and h. pylori contamination of the gastric and duodenal mucosa.19911801479
susceptibility of helicobacter pylori to metronidazole. 19911802703
helicobacter pylori and gastric premalignant conditions.a hypothetical sequence occurs in the stomach from h. pylori infection to premalignant conditions. this sequence is characterized by several well documented steps. first, the h. pylori infection seems to be the main course of chronic gastritis, and is seen to be associated with gastritis at least in 80% of the cases. second, chronic gastritis tends to slowly progress to atrophy and intestinal metaplasia of the underlying mucosa in a great proportion of affected subjects, this progression of chro ...19911803836
[the role of serology in the diagnosis of helicobacter (campylobacter) pylori infection].the purpose of the communication is to review the different aspects of the helicobacter (campylobacter) pylori infection. the first part of the communication is devoted to the description of the different gastric pathologies induced by the helicobacter pylori infection and to the different methods used for the detection of this infection. today a consensus assesses a causal role to helicobacter pylori in the development of chronic active gastritis (or type b gastritis), in the pathogenesis of du ...19911803838
[helicobacter pylori].of great impact has been the studies of helicobacter pylori and its association with illnesses of the stomach and duodenum. we have reviewed and outlined the pathological mechanisms by which h. pylori causes illness, the results of experiments in animals, the different methods of diagnosis (invasive and noninvasive). we also have detailed the association of h. pylori infection in different gastric conditions such as chronic active gastritis and peptic ulcer disease and the results obtained after ...19911804327
[uncomplicated peptic ulcer disease. the therapeutic prospects and practice].the majority of peptic ulcers heal if gastric acidity is adequately reduced during a fraction of the day, either increasing intraluminal ph, or acting upon parietal cells membrane receptors. a single nocturnal dose of h2-receptor antagonists heal 90% of duodenal lesions within 6 weeks; gastric ulcers take about 8 weeks. elimination half-life is short; there is no reversible. few drug interactions are clinically significant. antacids (aluminum hydroxide) and muscarine-1 receptor antagonists (pire ...19911804328
chronic gastritis associated with helicobacter pylori. correlation between histological and bacteriological findings.biopsy specimens of gastric and duodenal mucosa from 326 patients were examined bacteriologically and histologically to determine the correlation between chronic gastritis and h. pylori colonization. h. pylori was identified in 111 (66.5%) patients with evidence of chronic gastritis and in 97 (82.2%) individuals who had gastritis associated with other pathology (gastric o duodenal ulcer, carcinoma o bulboduodenitis). the spiral bacteria was found more frequently in specimens with chronic superfi ...19911804425
two point analysis 15-minute 14c-urea breath test for diagnosing helicobacter pylori infection.the value of a two point analysis (double sample) 14c-urea breath test in diagnosing helicobacter pylori (hp) infection in patients with suspected acid peptic disease has been studied and compared to histology and to a rapid agar plate urease test in 76 patients. using the histological finding of hp as the gold standard, the 14c-breath test was positive in 59 of the 61 histologically confirmed infected patients and in 3 of the 15 noninfected ones, giving a sensitivity of 97% and specificity of 8 ...19911804728
effect of alcohol consumption on the risk of helicobacter pylori infection.to investigate the effect of alcohol consumption on the risk of helicobacter pylori infection, standardized questionnaires on drinking habits were used to interview 451 patients, whose h. pylori status was determined both by culture and serology. reported alcohol consumption did not increase the risk of h. pylori infection (a 1.0 odds ratio, ci95 0.6-1.6). however, when the patients were divided into two age-groups, those under 35 years who reported to use alcohol seemed to have a slightly highe ...19911804737
enhanced clearing of helicobacter pylori after omeprazole plus roxithromycin treatment.the in vitro antibacterial activity of omeprazole against eight strains of helicobacter pylori was evaluated. minimum inhibitory concentration (mic) values were 32 micrograms/ml and 64 micrograms/ml (mic50 and mic90 respectively). we performed a randomized single blind study comparing the efficacy of omeprazole alone (for 4 weeks) or combined with roxithromycin (for 2 weeks) in the treatment of duodenal ulcer and chronic active gastritis associated with h. pylori infection, h. pylori was eradica ...19911804757
[development of gentamicin sulfate sustained release tablet remaining-floating in stomach].gentamicin sulfate sustained-release tablet remaining-floating in stomach (g-hbs) was developed based on the hydrodynamically balanced system. the dissolution rate of g-hbs was determined by rotary basket method (100 r/min, 37 +/- 0.5 degrees c, 0.1 mol/l hcl). the release characteristics of g-hbs showed basically first order kinetics with the dissolution rate constant (kr) of 0.3992 h-1. the mean dissolution time (mdt) of g-hbs was 2.53 h-1. the density of g-hbs was found to have no significant ...19911805513
[antibodies against helicobacter pylori in gastroenterology personnel, patients and the healthy population].we have studied the prevalence of igg antibodies to h. pylori in gastroenterology personnel, patients and healthy blood donors to determinate if there is a presumable high risk of infection among the first group, frequently at risk of exposure to gastrointestinal secretions. the positive percentage of sera in the gastroenterology personnel was 30.4% and in the healthy control group (mean age 35.8 years) was 38.5% (p = 0.620). in the patient group, the rate of positive results was 90% and in thei ...19911805887
[the role of helicobacter pylori in ulcer disease]. 19911808886
helicobacter pylori in barrett's esophagus.barrett's esophagus is an anatomicoclinical state in which, due to the prolonged action of gastroesophageal reflux, the squamous epithelium is replaced by columnar epithelium. helicobacter pylori has been implicated in the pathogenesis of various gastrointestinal disorders and has occasionally been observed in barrett's esophagus. the aim of this study is to determine the incidence of h. pylori in barrett's esophagus and try to establish its role in the pathogenesis of this disorder. h. pylori w ...19911810538
flocculation of venereal disease research laboratory reagent by helicobacter pylori.helicobacter pylori strains flocculated with venereal disease research laboratory (vdrl) reagent in a glass slide test. other pathogenic bacterial and fungal strains were nonreactive. the specific vdrl reaction property of helicobacter pylori indicates an affinity of the cells for lipoidal substances, and can be used as a diagnostic aid for species identification.19911810734
[campylobacter pylori gastroduodenitis in children with juvenile rheumatoid arthritis].clinico-morphological study of the gastroduodenal system and also morphometric investigations of the degree of gastroduodenitis activity and the condition of the local immune system were made in 30 children aged from 4 to 15 years with juvenile rheumatoid arthritis (jra). microbiological, histological and electron microscopic methods for revealing campylobacter pylori (cp) were used. interrelationship between various clinical manifestations of jra with the nature of gastroduodenal system affecti ...19911812557
helicobacter pylori; histological and cultural correlation in chronic gastritis.seventy seven antral biopsies were collected from patients attending endoscopy clinic at king khalid university hospital, riyadh, saudi arabia during a period of six months between december 1988 to may 1989. of these 69 (89.6%) showed chronic gastritis as well as helicobacter-like organisms (hlos) in the biopsy specimens while 63 (81.8%) of biopsies grew helicobacter pylori on culture. these findings indicate a good correlation between the histological diagnosis of chronic gastritis and isolatio ...19911814029
[helicobacter pylori: identification and correlation between its presence and the histological modification of the mucous membrane in the course of duodenal ulcer and chronic gastritis]. 19911814511
helicobacter pylori infection in dyspeptic patients. 19911814886
anti-helicobacter pylori igg levels in abattoir workers.the aim of our study was to detect antibodies against helicobacter pylori (h. pylori) in abattoir workers whose activity was variable (pig, poultry-carcasses, poultry-intestinal organs treatment). an adsorption of all sera with h. pylori and campylobacter species known to be ubiquitous and responsible for zoonosis was included in the elisa reaction to eliminate possible cross-reactions between these species. statistically higher specific titres of igg antibodies against h. pylori were observed i ...19911816012
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