Publications

[lyme disease of a neurological form. apropos of 2 new cases of meningoradiculitis].		1987	2956669
[chronic erythema migrans as initial symptom of lyme disease].		1987	3574543
focal encephalitis in a young woman 6 years after the onset of lyme disease: tertiary lyme disease?	a 19-year-old woman had severe focal inflammatory encephalitis. six years previously, she had had classic untreated lyme disease characterized by erythema chronicum migrans, bilateral facial palsies, and lymphocytic meningitis. during her recent encephalitic illness, lyme disease serologic tests were positive by indirect immunofluorescence microscopy, enzyme-linked immunosorbent assay, and western blot (immunoblot technique) testing. we hypothesize that the patient's focal inflammatory encephali ...	1987	3561045
severe encephalopathy associated with lyme disease.		1987	2882097
lyme disease in europe and north america.		1987	2882096
[pain syndromes in tick-borne neuroborreliosis. clinical aspects and differential diagnosis.].	tick-borne borreliosis (borrelia burgdorferi) is a common and complex disorder affecting the skin, the joints and the nervous system. it progresses through different clinical stages. the clinical spectrum of neuroborreliosis has expanded since the introduction and widespread application of specific serological tests. we have investigated 41 patients with bannwarth's meningopolyneuritis (mpn) as the classical form of neuroborreliosis, in a prospective (26 patients) and a retrospective (15 patient ...	1987	18415556
lyme disease. a review.		1988	3068778
lyme disease: acute focal meningoencephalitis in a child.		1988	3054790
paralysis of recurrent laryngeal nerve in lyme disease.		1988	2903968
treatment of lyme disease.		1988	3233968
lyme disease: a historical perspective.		1988	3068078
lyme disease in missouri.		1988	3265759
[heart involvement in lyme disease].		1988	3212945
[lyme disease evolving over 12 years].		1988	3212258
lyme disease: ocular manifestations.	we present three cases of lyme disease, complicated by ocular manifestations. these included optic nerve abnormalities and corneal opacities.	1988	3207308
lyme disease--the great imitator.		1988	3267980
antibodies to myelin basic protein in lyme disease.		1988	2457637
lyme disease in canada.		1988	3395939
[characteristics of the clinical diagnosis and treatment of tick-borne borreliosis (lyme disease)].		1988	3195095
[lyme disease].		1988	3070497
lyme disease.		1988	3405519
treatment of lyme disease.		1988	3380058
[some recent results and developments in dermatovenerology].	our own results in dermatology are highlighted, such as the oral "hairy" leukoplakia associated with aids, treatment with acyclovir for herpetic infections, laser therapy for angiomas, lyme disease, x-ray therapy in kaposi's sarcomas, photosensitivity reactions by treatment with thiazid diuretics and follicular mucinosis associated with t-cell lymphomas (mycosis fungoides).	1988	3210865
[lyme disease in otoneurology practice].		1988	3168036
[lyme disease manifested by polyradiculoneuritis without hypercytosis of the cerebrospinal fluid].		1988	2969555
lyme disease in canada.		1988	3250561
lyme disease: epidemiological characteristics in maryland, 1984-1986.		1988	3405041
tick-borne diseases.	tick-borne diseases have their peak incidence in the spring and summer. the different infections caused by tick vectors have certain geographic locations and unique clinical presentations. the most common tick-transmitted infection is lyme disease. early diagnosis of tick-borne disease is essential so that effective and, in some cases, lifesaving antibiotic therapy can be instituted. preventive measures are simple.	1988	3289344
treatment of late lyme borreliosis--randomised comparison of ceftriaxone and penicillin.	23 patients with clinically active late lyme disease were randomly assigned to intravenous treatment with either penicillin or ceftriaxone. of the 10 treated with penicillin, 5 were judged treatment failures; of the 13 who received ceftriaxone, only 1 did not respond. an additional 31 patients were subsequently treated with ceftriaxone 4 g/day (n = 17) or 2 g/day (n = 14); success rates in both groups were comparable to those in the cohort randomised to ceftriaxone. patients unresponsive to ceft ...	1988	2897008
mild lyme disease.		1988	2896854
[meningoradiculoencephalitis in lyme disease. a case with major regressive mental disorders].		1988	2966957
bilateral diffuse choroiditis and exudative retinal detachments with evidence of lyme disease.		1988	3282440
british columbia. lyme disease in horses.		1988	17423037
[crossed reactions in lyme disease. value of the western blot].		1988	2965350
[from tick bite to lyme disease: evolution of a clinical concept].		1988	3287542
[lyme disease: its principal neurological and rheumatological aspects].		1988	3259708
lyme disease--connecticut.		1988	3233680
[lyme disease with multiple joint involvement and a major inflammatory syndrome].		1988	2966360
leads from the mmwr. lyme disease--connecticut.		1988	3276944
[lyme disease in pregnancy].		1988	3370692
multiple sclerosis is a chronic central nervous system infection by a spirochetal agent.	multiple sclerosis (ms) is a chronic central nervous system (cns) infection similar to lyme disease or neurosyphilis in its latency period, pathogenesis, symptoms, histopathology and chronic cns involvement. it does not have as yet a fully identified spirochetal etiological agent. much research and clinical support for this hypothesis was published before 1954 and is based on silver staining of neural lesions, animal isolation of the etiologic agent and the characteristic symptoms and pathogenes ...	1988	3357458
pattern of lyme arthritis in europe: report of 14 cases.	fourteen cases of lyme arthritis are reported. the most frequent picture was that of oligoarthritis appearing in that part of the leg where the cutaneous or neurological complications, or both, of lyme disease had developed before the arthritis. in most cases recovery followed a single 10 day course of intravenous (iv) penicillin therapy. arthritis was the presenting feature of lyme disease in three cases.	1988	3355251
possible pitfalls of an indirect immunofluorescence assay as the sole serological test in the diagnosis of lyme disease.		1988	3132389
bilateral keratitis as a manifestation of lyme disease.	an 11-year-old girl developed bilateral keratitis, which we believe was a manifestation of lyme disease. she had had several attacks of lyme arthritis and was twice treated with parenteral penicillin. the keratitis developed five years after the initial episode of lyme arthritis at a time when there were no other manifestations of lyme disease. it cleared completely in both eyes after topical corticosteroid therapy.	1988	3337196
lyme disease--connecticut.		1988	3122001
lyme disease treatment needs further preventive measures.		1988	3347018
[rheumatologic manifestations of lyme disease].	the characteristics of 15 patients with lyme disease have been retrospectively reviewed; 12 patients had lymphocytic meningitis with mono or polyradiculitis including facial neuritis; 5 patients had mono or oligo-arthritis; 4 patients had inflammatory enthesopathy-like complaints which were the only expression of the disease in 2 of them. all the patients received antibiotic treatment. a dramatic clinical improvement was noted in all patients within four days. a rapid response to treatment seems ...	1988	3266722
[lyme disease and hla-dr antigens: relation between hla-dr2 and hla-dr4].		1988	3258452
analogous cases of lyme disease.		1988	3234981
otoneurological symptomatology in lyme disease.		1988	3213733
treatment of erythema chronicum migrans of lyme disease.	between june 1981 and july 1987 the efficacy of antibiotic treatment of 215 patients with erythema chronicum migrans of lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of lyme disease. the principal antibiotics utilized to treat 161 patients through 1986 were varying doses of tetracycline, or penicillin alone or in combination with probenecid. two of 80 patients with a minor form of the illness and 17 of 81 patients with a major ...	1988	3190102
nervous system abnormalities in lyme disease.		1988	3190096
[lesions of the joints in lyme disease].		1988	3062804
[lyme disease].		1988	2977898
clinical pathologic correlations of lyme disease by stage.	lyme disease is capable of producing a wide variety of clinical pathologic conditions and lesions having in common histologic features of collagen-vascular disease. the plasma cell is an omnipotent inflammatory responder in most tissues involved by lyme disease, ranging from relatively acute to lesions that have gone on for years. vascular thickening also seems to be prominent, and in the dermis is accompanied by scleroderma-like collagen expansion. the disease in some ways resembles the respons ...	1988	2847622
clinical and serologic evaluations of induced borrelia burgdorferi infection in dogs.	adult beagles were used to evaluate clinical signs and serologic response after inoculation with, or exposure to, borrelia burgdorferi. an indirect immunofluorescent assay (ifa) and 2 elisa were used to monitor the serologic response to b burgdorferi. feeding infected ticks on 4 dogs (group 1) failed to cause seroconversion, and sc inoculation with 500 organisms caused minimal seroconversion in 2 of 4 dogs (group 2). at 56 days, approximately 3.01 x 10(8) b burgdorferi organisms were injected iv ...	1988	3041881
[serodiagnosis of lyme borreliosis].	there are various serodiagnostic tests available for the detection of antibodies against borrelia burgdorferi. an indirect hemagglutination assay, which can detect both igm and igg antibodies, was developed for antibody screening. regarding the confirmation and differentiation of igm and igg, we use the indirect immunofluorescence assay (most specific when performed with sera previously absorbed with treponema phagedenis) as well as the elisa test. the detection of significantly elevated antibod ...	1988	3043955
serodiagnosis of early lyme disease: analysis of igm and igg antibody responses by using an antibody-capture enzyme immunoassay.	we used an antibody-capture enzyme immunoassay (eia) to evaluate the early antibody responses to borrelia burgdorferi in paired sera from 30 patients with erythema chronicum migrans. during acute disease, 20 (67%) patients had elevated specific igm responses, and by convalescence (one to four weeks after treatment), 28 (93%) patients had increased igm or igg responses. in acute specimens, elevated igm responses correlated with disseminated infection; however, by convalescence, most patients with ...	1988	3049839
seronegative lyme disease. dissociation of specific t- and b-lymphocyte responses to borrelia burgdorferi.	the diagnosis of lyme disease often depends on the measurement of serum antibodies to borrelia burgdorferi, the spirochete that causes this disorder. although prompt treatment with antibiotics may abrogate the antibody response to the infection, symptoms persist in some patients. we studied 17 patients who had presented with acute lyme disease and received prompt treatment with oral antibiotics, but in whom chronic lyme disease subsequently developed. although these patients had clinically activ ...	1988	3054554
[lyme disease. clinical, biological and developmental aspects. 29 cases in the orléans region].	the description of lyme's disease (ld) in 3 stages (like syphilis), has now become classical. 29 cases of ld, between june 1981 and november 1986, have been recorded at the hospital in orleans. the first twelve patients that were clinically diagnosed before the serology was introduced in france, have been recalled in order to search for possible late forms and assay their antibody level of anti-borrelia burgdorferi. the preponderance of neurological forms (22 cases) and the scarcity of periphera ...	1988	3055243
modulation of natural killer cell activity by borrelia burgdorferi.		1988	3056196
serologic diagnosis of lyme disease.	indirect fluorescent antibody tests and enzyme-linked immunosorbent assays are being used as laboratory aids for the diagnosis of lyme disease and related disorders. depending on the needs, polyvalent or class-specific reagents can be used to detect total immunoglobulins (ig) or igm and igg antibodies. the sensitivities of these assays are relatively low when serum samples are obtained from patients within 3 weeks after onset of erythema migrans and are tested by either the ifa method or elisa. ...	1988	3056197
mammalian and avian reservoirs for borrelia burgdorferi.		1988	3056198
synovial fluid eosinophilia in lyme disease.	we describe three 14-year-old boys who developed synovial fluid eosinophilia associated with lyme disease. one patient, with arthritis that began in 1975, had the first documented case of lyme disease in new jersey. lyme disease should be considered when eosinophilia is noted on analysis of synovial fluid from patients with undiagnosed arthritis.	1988	3056421
clinical and neuroimmunological findings in chronic borrelia burgdorferi radiculomyelitis (lyme disease).		1988	3058745
laboratory aspects of lyme borreliosis.	lyme borreliosis (lyme disease), a common tick-borne disorder of people and domestic animals in north america and europe, is caused by the spirochete borrelia burgdorferi. following the discovery and initial propagation of this agent in 1981 came revelations that other tick-associated infectious disorders are but different forms of lyme borreliosis. a challenge for the clinician and microbiology laboratory is confirmation that a skin rash, a chronic meningitis, an episode of myocarditis, or an a ...	1988	3069200
[intermittent fever attacks. lyme disease without erythema chronicum migrans].		1988	3069790
[multiple neurologic manifestations of borrelia burgdorferi infection].	the neurological spectrum of borrelia burgdorferi infections is still enlarging. we review epidemiological, pathological and serological data of lyme disease. the course of the disease is divided in three stages: stage 1 during the first month is characterised by erythema chronicum migrans and associated manifestations; stage 2 includes not only the classical european meningoradiculitis but also less specific neurological symptoms: isolated lymphocytic meningitis with an acute or even relapsing ...	1988	3070690
[a new type of spirochete infection: lyme disease].		1988	3071626
[cutaneous b cell lymphoma in chronic borrelia burgdorferi infection. report of 2 cases and a review of the literature].	low-grade malignant b-cell lymphomas of the skin can be distinguished from lymphadenosis benigna cutis (bäfverstedt) by immunohistological methods developed in the last few years. its coexistence with borrelia burgdorferi infection can be shown by clinical and serological findings. in the chronic stage of this infection, lymphocytic cell infiltrations consistent with histological and immunohistological findings of malignant b-cell lymphoma can be found. predominantly at the extremities, multiple ...	1988	3072322
[identification of borrelia isolated in the ussr from ixodes persulcatus schulze ticks].	the data on the identification of 7 spirochetal isolates from ixodes persulcatus ticks collected in leningrad province and the khabarovsk territory are presented. these isolates, studied with the use of monoclonal antibodies, have been shown to belong to borrelia burgdorferi.	1988	3072807
[lyme disease--a new infection from natural foci].		1988	2965619
[identification and initial results of the study of lyme disease in northwestern ussr].		1988	2966893
[comparative evaluation of 2 methods for demonstrating borrelia in ticks--the vectors of lyme disease].		1988	2978047
borrelia burgdorferi in a newborn despite oral penicillin for lyme borreliosis during pregnancy.		1988	3130607
[thrombocytopenic purpura caused by borrelia burgdorferi?].	in november 1983 a woman born in 1902 was found to have thrombocytopenic purpura with a platelet count of 14,000/microliter. examination of the sternal marrow resulted in a suspected diagnosis of werlhof's disease. platelet counts dropped at times to below 7,000/microliter during immunosuppressive treatment with corticosteroids and azathioprine of three months' duration. when this treatment was discontinued spontaneous remission occurred until july 1984. acrodermatitis chronica atrophicans was d ...	1988	3133191
[case report of lyme disease showing large erythematous lesion in the abdomen].		1988	3138324
lyme disease with acute purulent meningitis.		1988	3139148
broad-host-range plasmid and m13 bacteriophage-derived vectors for promoter analysis in escherichia coli and pseudomonas aeruginosa.	a set of bacteriophage and plasmid vectors containing xyle as a reporter gene was constructed for the analysis of promoters functional in escherichia coli and in other gram-negative bacteria. two m13 bacteriophage derivatives, m13mvdx18 and m13mmk010, were designed for rapid cloning, screening and sequencing of dna fragments promoting transcription in e. coli. to demonstrate their utility, total cellular dna from a variety of bacterial species including pseudomonas aeruginosa strain pao was shot ...	1988	3149945
the use of doxycycline in nervous system borrelia burgdorferi infection.	alternatives to high dose benzylpenicillin treatment are sought for in patients with mild borrelia burgdorferi nervous system infection. doxycycline 100 mg twice daily for 10-20 days was used in nine patients with radicular pains, vertigo or weakness in the legs caused by b. burgdorferi infection. the patients had suffered from neurologic symptoms for a median time of five months. in eight patients doxycycline was orally administered and in one intravenously. all nine patients had remission of r ...	1988	3166545
intensity and duration of borrelia burgdorferi and babesia microti infectivity in rodent hosts.		1988	3170076
ticks and biting insects infected with the etiologic agent of lyme disease, borrelia burgdorferi.	members of 18 species of ticks, mosquitoes, horse flies, and deer flies were collected in southeastern connecticut and tested by indirect fluorescent-antibody staining methods for borrelia burgdorferi, the etiologic agent of lyme disease. an infection rate of 36.2% (116 tested), recorded for immature ixodes dammini, exceeded positivity values for all other arthropod species. prevalence of infection for hematophagous insects ranged from 2.9% of 105 hybomitra lasiophthalma to 14.3% of seven hybomi ...	1988	3170711
lyme borreliosis in the soviet union: a cooperative us-ussr report.	we identified 90 patients with tick-borne erythema migrans in the union of soviet socialist republics (ussr) in areas from the western baltic republics to the maritime territory on the pacific ocean. symptoms associated with the erythema included fever, malaise and fatigue, headache, myalgias, arthralgias, or regional lymphadenopathy. within two weeks to four months, 58 (64%) of the patients developed neurological abnormalities, particularly radicular pain, cranial neuritis, or lymphocytic menin ...	1988	3171226
cultivation of borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to lyme borreliosis.		1988	3171237
characterization of a circular plasmid from borrelia burgdorferi, etiologic agent of lyme disease.	borrelia burgdorferi, the etiologic agent of lyme disease, was recently shown to contain plasmid dna. two plasmid species have been described in strain ct1, a wisconsin tick isolate: a 9.2-kilobase entity; and a larger, 70-kilobase entity. characterization of the 9.2-kilobase entity by using dnase i and restriction endonucleases demonstrated that the plasmid is supercoiled and exists as a stable dimer in this strain. the role played by the plasmid in b. burgdorferi is unknown.	1988	3183006
new borrelia burgdorferi antigenic variant isolated from ixodes dammini from upstate new york.	a previously undescribed borrelia burgdorferi antigenic variant was isolated from each of four ixodes dammini larvae removed from white-footed mice, peromyscus leucopus, captured in millbrook, n.y. this site is in the northern range of the known distribution of the tick in the northeastern united states. the molecular weights of approximately 32,500 and 35,500 for outer surface a and outer surface b proteins, respectively, were distinctly higher than those for previously characterized isolates f ...	1988	3183008
[epidemiology of lyme disease].		1988	3187264
[borrelia burgdorferi encephalomyelitis].	we report two patients with chronic encephalomyelitis due to borrelia burgdorferi in whom the definite diagnosis was delayed because of atypical clinical features. the first patient presented with chronic spastic paraparesis, slight ataxia and nystagmus of several years' duration. a tentative diagnosis of multiple sclerosis was made in spite of important abnormalities of the csf biological characteristics. the second patient presented with an acute aphasia and a bilateral babinski's sign. he was ...	1988	3187297
ticks parasitizing humans in a lyme disease endemic area of southern new york state.	a total of 126 tick specimens were submitted by tick bite victims to the westchester county department of health, white plains, new york, and to the new york medical college, medical entomology laboratory, armonk, new york, during 1985. these included 96 (76.2%) ixodes dammini, 26 (20.6%) dermacentor variabilis, and two (1.6%) amblyomma americanum. i. dammini parasitism was reported during all months of the year except december and february and involved all life stages. only d. variabilis adults ...	1988	3189288
lyme disease and related disorders.		1988	3190087
lyme disease: antigens of borrelia burgdorferi and immune responses to them.		1988	3190088
the genes encoding major surface proteins of borrelia burgdorferi are located on a plasmid.		1988	3190089
development of borrelia burgdorferi in ixodid tick vectors.		1988	3190091
vector tick populations and lyme disease. a summary of control strategies.	although many aspects of lyme disease have been intensely studied for over a decade, little research has been directed toward control of the principal tick vector, ixodes dammini. ecological and epidemiological investigations have provided not only an ample understanding of tick biology and behavior, they have also identified the types of areas at risk for disease transmission. the advantages and limitations of previous attempts to control i. dammini by host reduction, habitat modification, and ...	1988	3190092
prospects for suppressing transmission of lyme disease.	a variety of methods have been developed to prevent human infection by the lyme disease spirochete in the northeastern united states, mainly based on the observations that nymphal ixodes dammini serve as vector, that deer serve as hosts for the reproductive stage of this tick, that white-footed mice serve as the reservoir of infection, and that nymphs are most abundant in early summer and must attach for 2 days before infection is transmitted. methods for personal protection included seasonal av ...	1988	3190093
host responses to borrelia burgdorferi in dogs and horses.	by using paired sera the igm and igg host responses were analyzed in dogs with elisa and western blot techniques. antibodies in clinical seropositive dogs bound to 4-25 igm and up to 40 or more igg antigenic determinants. early igm response to the 41-kda flagellin persisted for at least 9 months and involved as many as seven other peptides. igg response expanded later in the disease and involved more immunogens than are currently recognized in late human disease. a percentage of asymptomatic dog ...	1988	3190094
borrelia burgdorferi infection in wisconsin horses and cows.	blood samples from wisconsin horses and cows suspected of having clinical disease due to borrelia burgdorferi infection were submitted by veterinary practitioners. all serum, milk, colostrum, and synovial samples were tested for b. burgdorferi antibodies by immunofluorescence. whole blood, milk, colostrum, and synovial fluid samples were cultured for b. burgdorferi. records were kept on the clinical signs of antibody-positive animals, date of sample, and location of the animal by county. of the ...	1988	3190095
epidemiologic studies of lyme disease in horses and their public health significance.	a serologic survey of horses in the new jersey-pennsylvania area demonstrated that about 10% (6.2-14.2%) have significant levels of serum antibody to borrelia burgdorferi. however, in a highly endemic area of central new jersey, up to 60% of the mares and yearlings samples on one farm were seropositive. in 1983, sera from this same farm exhibited only 12% positives in mares and 35% positives in yearlings. longitudinal studies of paired sera obtained from individual yearlings over a 6-month perio ...	1988	3190097
experimental infection of the hamster with borrelia burgdorferi.		1988	3190098
the geographic distribution of lyme disease in the united states.	in 1982, national surveillance for lyme disease was established by the centers for disease control to monitor trends and determine endemic geographic areas. initially, the endemic areas corresponded to the known distribution of ixodes dammini, a five-state area of the northeastern seaboard (new york, new jersey, connecticut, rhode island, and massachusetts) and wisconsin and minnesota. increasing numbers of cases have been reported outside these areas, however, 86% of the provisional 5731 cases ...	1988	3190099