Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| genetic variation of glycoproteins b and h of human herpesvirus 7 in hong kong. | glycoprotein b (gb) and glycoprotein h (gh) of human herpesvirus 7 (hhv-7) are believed to play an important role in virus entry and as targets for host immune response. this study examined the genetic diversity of these glycoproteins among 90 hhv-7 isolates collected from different individuals in hong kong. overall, both the gb and gh genes were found to be highly conserved. nucleotide polymorphism was detected only at four positions of the gb-encoding region, and all of these were synonymous s ... | 2003 | 12966550 |
| transmission dynamics and control of severe acute respiratory syndrome. | severe acute respiratory syndrome (sars) is a recently described illness of humans that has spread widely over the past 6 months. with the use of detailed epidemiologic data from singapore and epidemic curves from other settings, we estimated the reproductive number for sars in the absence of interventions and in the presence of control efforts. we estimate that a single infectious case of sars will infect about three secondary cases in a population that has not yet instituted control measures. ... | 2003 | 12766207 |
| common nod2 polymorphisms in hong kong chinese patients with systemic lupus erythematosus. | 2004 | 14681560 | |
| investigation of killer cell immunoglobulinlike receptor gene diversity: i. kir2dl4. | polymerase chain reaction-sequence-specific oligonucleotide probes typing procedures identifying alleles of the killer immunoglobulin-like gene (kir2dl4) have been established. the methods, designed around the specific amplification of the d0 and d2 domains of this gene, produce discrimination of kir2dl4 alleles. the methods have been applied to a healthy northern irish control group, establishing frequencies for this caucasian population. additionally, the kir2dl4 allele status of cell line dna ... | 2004 | 14700593 |
| identification of serum amyloid a protein as a potentially useful biomarker to monitor relapse of nasopharyngeal cancer by serum proteomic profiling. | nasopharyngeal cancer (npc) is a common cancer in hong kong, and relapse can occur frequently. using protein chip profiling analysis, we aimed to identify serum biomarkers that were useful in the diagnosis of relapse in npc. experimental design: profiling analysis was performed on 704 sera collected from 42 npc patients, 39 lung cancer patients, 30 patients with the benign metabolic disorder thyrotoxicosis (tx), and 35 normal individuals (nm). protein profile in each npc patient during clinical ... | 2004 | 14734450 |
| wet markets--a continuing source of severe acute respiratory syndrome and influenza? | context: live-animal markets (wet markets) provide a source of vertebrate and invertebrate animals for customers in tropical and subtropical regions of the world. wet markets sell live poultry, fish, reptiles, and mammals of every kind. live-poultry markets (mostly chicken, pigeon, quail, ducks, geese, and a wide range of exotic wild-caught and farm-raised fowl) are usually separated from markets selling fish or red-meat animals, but the stalls can be near each other with no physical separation. ... | 2004 | 14738798 |
| cerebrotendinous xanthomatosis in a hong kong chinese kinship with a novel splicing site mutation ivs6-1g>t in the sterol 27-hydroxylase gene. | we reported a hong kong chinese proband with cerebrotendinous xanthomatosis in which a novel acceptor splicing site mutation (ivs6-1g>t) was identified. family screening revealed the same mutation in his elder brother and the youngest sister. all the three affected siblings were compound heterozygous for ivs6-1g>t and a known missense mutation r372q (genbank accession no. m62401). significant phenotypic variation was noted among them that the youngest sister was still symptom-free at the time of ... | 2004 | 14741198 |
| risk assessment of exposure to volatile organic compounds in different indoor environments. | the lifetime cancer risks of exposure of cooks and food service workers, office workers, housewives, and schoolchildren in hong kong to volatile organic compounds (vocs) in their respective indoor premises during normal indoor activities were assessed. the estimated cancer risk for housewives was the highest, and the second-highest lifetime cancer risk to voc exposure was for the groups of food service and office workers. within a certain group of the population, the lifetime cancer risk of the ... | 2004 | 14643287 |
| epidemiology of hepatitis a and hepatitis e infection and their determinants in adult chinese community in hong kong. | current epidemiology of hepatitis a virus (hav) and hepatitis e virus (hev) in hong kong was evaluated in 936 adult chinese subjects recruited through a telephone interview in 2001. some 15% of the subjects had igg antibodies to both hav and hev while 665 (71.0%) and 176 (18.8%) had anti-hav and anti-hev, respectively. age was the most significant independent factor. six hundred thirty-eight (79.8%) and 165 (20.7%) subjects aged > or =30 had anti-hav and anti-hev, respectively, as compared with ... | 2004 | 14981755 |
| re-emergence of fatal human influenza a subtype h5n1 disease. | human disease associated with influenza a subtype h5n1 re-emerged in january, 2003, for the first time since an outbreak in hong kong in 1997. patients with h5n1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [ip-10] and monokine induced by interferon gamma [mig]). taken together with a previous report that h5n1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokin ... | 2004 | 14987888 |
| auricular anthropometry of hong kong chinese babies. | to provide a database of the auricular measurements of chinese infants born in hong kong. | 2004 | 14989749 |
| risk factors affecting the severity of single vehicle traffic accidents in hong kong. | a population-based case-control study was conducted to examine factors affecting the severity of single vehicle traffic accidents in hong kong. in particular, single vehicle accident data of three major vehicle types, namely private vehicles, goods vehicles and motorcycles, which contributed to over 80% of all single vehicle accidents during the 2-year-period 1999-2000, were considered. data were obtained from the newly implemented traffic accident data system (trads), which was developed jointl ... | 2004 | 15003577 |
| pb contamination and isotopic composition of urban soils in hong kong. | in the urban environment, intense human activities can lead to degradation of environmental quality and have potential long-term effects on human health. in the present study, pb contamination of urban soil cores in hong kong was investigated using a combination of the 'total' concentration, chemical partitioning and isotopic composition of pb in the soils. the analytical results showed that urban soil cores in close vicinity to high traffic volumes (> 40000 vehicles per day) were usually contam ... | 2004 | 14967510 |
| excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in hong kong. | it is widely held that southern china is a hypothetical influenza epicentre for the emergence of pandemic influenza viruses. however, influenza is perceived as a relatively unimportant infection in this part of the world compared with western countries. hong kong is situated within the hypothetical epicentre and serves as a sentinel post for the region. in a retrospective study, the influenza-associated excess hospitalisations in a regional hospital for pneumonia, chronic obstructive pulmonary d ... | 2004 | 15221909 |
| the use of recombinant human epidermal growth factor (rhegf) in a gentleman with drug-induced steven johnson syndrome. | a case of drug-induced steven johnson syndrome in a gentleman is reported. its course of treatment with rhegf was compared to conventional treatment in historical control. | 2004 | 15347507 |
| consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome. | we observed that 0 of 19 patients with human immunodeficiency virus type 1 (hiv-1) infection, including those with acquired immunodeficiency syndrome (aids), who were hospitalized together and who had close contact with 95 patients with severe acute respiratory syndrome (sars) on the same hospital floor contracted sars, whereas 6 of 28 medical workers who served on this floor contracted sars while caring for these patients. our investigation found that most of the patients with hiv-1/aids were r ... | 2004 | 15034838 |
| [pay enough attention to human infection with avian influenza virus]. | 2004 | 15157379 | |
| genome-wide scan for type 2 diabetes loci in hong kong chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. | we conducted an autosomal genome scan to map loci for type 2 diabetes in a hong kong chinese population. we studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of </=40 years. these families included a total of 126 affected sibpairs and 4 other affected relative pairs. nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [lod] >0.59, p(pointwise) < 0.05): chrom ... | 2004 | 15161769 |
| use of an electronic barcode system for patient identification during blood transfusion: 3-year experience in a regional hospital. | to evaluate the use of an electronic barcode system for patient identification during blood transfusion. | 2004 | 15181220 |
| stress and health-related quality of life among hiv-infected persons in hong kong. | this study examines the relationships among illness-related factors, stress, health-related quality of life (hrqol), and psychological distress in persons infected with the human immunodeficiency virus (hiv) living in hong kong (n = 55). participants completed questionnaires including a symptom checklist, modified hiv stressor scale (hivss), medical outcomes study short-form 36 (sf-36), and the hospital anxiety and depression scale (hads). in addition, cd4 count information was obtained. multipl ... | 2004 | 15187474 |
| molecular diversity of epstein-barr virus igg and iga antibody responses in nasopharyngeal carcinoma: a comparison of indonesian, chinese, and european subjects. | epstein-barr virus (ebv)-specific immunoblot analysis was used to reveal the molecular diversity of immunoglobulin (ig) g and iga antibody responses against epstein-barr nuclear antigen (ebna), early antigen (ea), and viral capsid antigen (vca) in serum samples from patients with nasopharyngeal carcinoma (npc) and control subjects, by use of immunofluorescence assay (ifa). control donors (n=150) showed igg responses to few ebv proteins--vca-p18, vca-p40, ebna1, and zebra--and sporadically weak i ... | 2004 | 15195243 |
| outcome of patients with positive epstein-barr virus serologic status in the absence of nasopharyngeal carcinoma in hong kong. | to evaluate the current clinical practice of follow-up and the outcomes of patients with raised epstein-barr virus (ebv) antibody levels but without pathological evidence of nasopharyngeal carcinoma (npc) for a possible risk of developing npc in the future. | 2004 | 15210561 |
| phenotypic alterations induced by the hong kong-prevalent epstein-barr virus-encoded lmp1 variant (2117-lmp1) in nasopharyngeal epithelial cells. | epstein-barr virus (ebv) is closely associated with nasopharyngeal carcinoma (npc), a common cancer in hong kong. the ebv-encoded lmp1 protein is believed to play an important role in cell transformation. we have previously identified a prevalent lmp1 variant (2117-lmp1) that is expressed in 86% of primary npc in hong kong. in this study, the biologic phenotypes induced by 2117-lmp1 were compared with those of the prototypic b95.8-lmp1 in an immortalized nasopharyngeal epithelial cell line, np69 ... | 2004 | 15027126 |
| sars-related virus predating sars outbreak, hong kong. | using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome-associated coronavirus (sars-cov) and/or animal sars-cov-like virus in 17 (1.8%) of 938 adults recruited in 2001. this finding suggests that a small proportion of healthy persons in hong kong had been exposed to sars-related viruses at least 2 years before the recent sars outbreak. | 2004 | 15030679 |
| [severe acute respiratory syndrome: a singular epidemic of viral pneumonia]. | infectious agent: the severe acute respiratory syndrome (sars) is a febrile pneumonia initially observed in china at the end of 2002. the infectious agent has rapidly been identified as a new coronavirus, baptised sars-associated coronavirus (cov-sars). transmission is inter-human, via respiratory particles mainly. clinical presentation and treatment: the clinical presentation is highly variable, from a mild fever to an acute respiratory distress syndrome. there is no specific treatment. ribavir ... | 2004 | 15041887 |
| responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. | in response to the emergence of severe infection capable of rapid global spread, who will issue a pandemic alert. such alerts are rare; however, on feb 19, 2003, a pandemic alert was issued in response to human infections caused by an avian h5n1 influenza virus, a/hong kong/213/03. h5n1 had been noted once before in human beings in 1997 and killed a third (6/18) of infected people. the 2003 variant seemed to have been transmitted directly from birds to human beings and caused fatal pneumonia in ... | 2004 | 15064027 |
| epstein-barr virus latent membrane protein 1 (lmp1) upregulates id1 expression in nasopharyngeal epithelial cells. | nasopharyngeal carcinoma is closely associated with epstein-barr virus (ebv) infection. the ebv-encoded lmp1 has cell transformation property. it suppresses cellular senescence and enhances cell survival in various cell types. many of the downstream events of lmp1 expression are mediated through its ability to activate nf-kappab. in this study, we report a novel function of lmp1 to induce id1 expression in nasopharyngeal epithelial cells (np69) and human embryonal kidney cells (hek293). the id1 ... | 2004 | 15064751 |
| non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma. | to present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among chinese patients. | 2004 | 15075426 |
| oseltamivir prophylaxis during the influenza season in a paediatric cancer centre: prospective observational study. | to determine the role of oseltamivir prophylaxis for immunocompromised patients. | 2004 | 15075430 |
| reemerging h5n1 influenza viruses in hong kong in 2002 are highly pathogenic to ducks. | waterfowl are the natural reservoir of all influenza a viruses, which are usually nonpathogenic in wild aquatic birds. however, in late 2002, outbreaks of highly pathogenic h5n1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two hong kong parks. in february 2003, an avian h5n1 virus closely related to one of these viruses was isolated from two humans with acute respiratory distress, one of whom died. antigenic analysis of the new avian isolat ... | 2004 | 15078970 |
| h5n1 influenza: a protean pandemic threat. | infection with avian influenza a virus of the h5n1 subtype (isolates a/hk/212/03 and a/hk/213/03) was fatal to one of two members of a family in southern china in 2003. this incident was preceded by lethal outbreaks of h5n1 influenza in waterfowl, which are the natural hosts of these viruses and, therefore, normally have asymptomatic infection. the hemagglutinin genes of the a/hk/212/03-like viruses isolated from humans and waterfowl share the lineage of the h5n1 viruses that caused the first kn ... | 2004 | 15148370 |
| transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern chinese women. | genetic contributions play an important role in determining bone mineral density (bmd) and bone turnover. transforming growth factor-beta (tgf-beta) is abundant in bone and has been implicated as an important regulator of both bone formation and resorption. several polymorphisms of the tgf-beta1 gene have recently been suggested to be associated with bmd and susceptibility to osteoporotic spine fractures. to determine the relationship between tgf-beta1 polymorphisms and bmd in southern chinese w ... | 2004 | 15354859 |
| genome-wide scan for metabolic syndrome and related quantitative traits in hong kong chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. | we conducted autosomal genome scans to map loci for metabolic syndrome (mes) and related traits in the hong kong family diabetes study. we selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on mes. we also selected 179 families with 897 members (2,127 relative pairs) for variance component-based linkage analyses on seven mes-related traits: waist circumference, systolic and diastolic blood pressure (bp), triglyceride, hdl cholesterol, ... | 2004 | 15448100 |
| delayed progression to death and to aids in a hong kong cohort of patients with advanced hiv type 1 disease during the era of highly active antiretroviral therapy. | the magnitude of the impact of highly active antiretroviral therapy (haart) since its introduction in non-western countries is not entirely clear. we studied disease progression among adult patients with advanced human immunodeficiency virus type 1 (hiv-1) infection in the pre-haart (i.e., 1996 and earlier) and haart eras in hong kong. | 2004 | 15472819 |
| prevalence and risk behaviors of hong kong males who seek cross-border same-sex partners in mainland china. | little is known about cross-border sex-networking behaviors among men who have sex with men (msm) goal: the goal of this study was to determine the prevalence of cross-border sex-networking in mainland china among msm in hong kong and the associated risk behaviors | 2004 | 15480120 |
| the chronology of the 2002-2003 sars mini pandemic. | severe acute respiratory syndrome (sars) was a new human disease in the autumn of 2002. it first occurred in southern china in november 2002 and was transported to hong kong on february 21, 2003 by an infected and ill patient. ten secondary cases spread the infection to two hospitals in hong kong and to singapore, toronto and hanoi. in march 2003 a novel coronavirus (sars-cov) was found to be the causative agent. within 11 weeks from the first sars case in hong kong it had spread to an additiona ... | 2004 | 15531249 |
| scary strains. | 2004 | 15543717 | |
| interindividual and intraindividual variability of the urinary 6beta-hydroxycortisol/cortisol ratio in chinese subjects: implications of its use for evaluating cyp3a activity. | the present study determined the interindividual and intrandividual variability of the urinary 6beta-hydroxycortisol/cortisol ratio, a useful marker for cyp3a induction and inhibition in chinese subjects. the study consisted of 2 parts. in part i, 82 healthy male chinese subjects underwent 3 study sessions, each separated by a 1-week interval. in part ii, 20 subjects who initially completed part i underwent another 3 sessions over a period of 3 to 4 months. during each session, a first-morning u ... | 2004 | 15545313 |
| influenza-associated mortality in hong kong. | the impact of influenza on mortality in countries in subtropical and tropical regions is poorly quantified. estimation of influenza-related illness in warm-climate regions is more difficult, because the seasonality of virus circulation is less well-defined. partly as a result of these factors, influenza vaccine is grossly underutilized in the tropics, even for individuals >or=65 years of age. | 2004 | 15578360 |
| breast milk substitutes in hong kong. | in 1981 the world health assembly (wha) adopted the international code of marketing of breast milk substitutes (the code) to support breastfeeding. despite improving trends, hong kong has low rates of breastfeeding compared to other developed countries. | 2004 | 15228560 |
| dioxin-like components in human breast milk collected from hong kong and guangzhou. | the h4iie rat hepatoma cell line was employed as a cell model to screen 7-ethoxyresorufin o-deethylase (erod)-tcdd equivalents (erod-teq) of human breast milk samples collected from hong kong and guangzhou, china. the screening methods employed a 96-well plate spectrofluorometer-erod assay. for cell-line validation, our results demonstrated a dose-dependent increase in the ah receptor-mediated response (i.e., cyp1a1 mrna and erod) of the cells upon exposure to a number of known ah receptor agoni ... | 2004 | 15261788 |
| associations between il12b polymorphisms and tuberculosis in the hong kong chinese population. | interleukin (il)-12 plays a vital role in regulating cell-mediated immunity against tuberculosis (tb). | 2004 | 15295696 |
| [the world prepares for influenza epidemics]. | 2004 | 15656418 | |
| experiences of online learning: students' perspective. | this paper explores students' views of an online learning initiative within a post-registration degree in nursing in hong kong. a self-administered questionnaire was used for data collection. one hundred and ninety eight students completed the study. online learning was seen to be convenient allowing students to study at their own pace and time. students reported that online learning enabled them to hold a higher level of accountability for their own learning and to learn independently. not all ... | 2004 | 15701540 |
| severe acute respiratory syndrome (sars) and healthcare workers. | the recent outbreak of severe acute respiratory synt drome (sars) was spread by international air travel, a direct result of globalization. the disease is caused by a novel coronavirus, transmitted from human to human by droplets or by direct contact. healthcare workers (hcws) were at high risk and accounted for a fifth of all cases globally. risk factors for infection in hcws included lack of awareness and preparedness when the disease first struck, poor institutional infection control measures ... | 2004 | 15702757 |
| association of essential hypertension with a microsatellite marker on chromosome 17. | hypertension is related to sodium intake, and many patients with essential hypertension are overweight and have the metabolic syndrome. we therefore studied microsatellite markers close to the thiazide-sensitive na-cl cotransporter on chromosome 16 and a quantitative trait locus for abdominal obesity-metabolic syndrome (aoms2) on chromosome 17, which have been found to be linked to hypertension in a previous genome scan in chinese. there were 84 hypertensive subjects (44 men, 40 women, age 53+/- ... | 2005 | 15716982 |
| b-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the s2 domain of the surface spike glycoprotein. | severe acute respiratory syndrome (sars) is a recently emerged infectious disease caused by a novel strain of coronavirus. examination of the immune responses of patients who have recovered from sars should provide important information for design of a safe and effective vaccine. we determined the continuous viral epitopes targeted by antibodies in plasma samples from convalescent sars patients through biopanning with a vast m13 phage display dodecapeptide library. these epitopes converged to ve ... | 2005 | 15731234 |
| the use of an herbal formula by hospital care workers during the severe acute respiratory syndrome epidemic in hong kong to prevent severe acute respiratory syndrome transmission, relieve influenza-related symptoms, and improve quality of life: a prospective cohort study. | to investigate the efficacy of an herbal formula in the prevention of severe acute respiratory syndrome (sars) transmission among health care workers. the secondary objectives are to investigate quality of life (qol) and symptomology changes among supplement users, and to evaluate the safety of this formula. | 2005 | 15750363 |
| cross-reactivity to highly pathogenic avian influenza h5n1 viruses after vaccination with nonadjuvanted and mf59-adjuvanted influenza a/duck/singapore/97 (h5n3) vaccine: a potential priming strategy. | antigenically well-matched vaccines against highly pathogenic avian influenza h5n1 viruses are urgently required. human serum samples after immunization with mf59 or nonadjuvanted a/duck/singapore/97 (h5n3) vaccine were tested for antibody to 1997-2004 human h5n1 viruses. antibody responses to 3 doses of nonadjuvanted vaccine were poor and were higher after mf59-adjuvanted vaccine, with seroconversion rates to a/hongkong/156/97, a/hongkong/213/03, a/thailand/16/04, and a/vietnam/1203/04 of 100% ... | 2005 | 15776364 |
| htlv-1-related lymphoma in hong kong chinese. | 2005 | 15609285 | |
| ventilation performance in the operating theatre against airborne infection: numerical study on an ultra-clean system. | a laminar airflow study was performed in a standard operating theatre in hong kong, the design of which followed the requirements of the uk health technical memorandum. the study of the ultra-clean ventilation system investigated the effectiveness of the laminar flow in: (i) preventing bioaerosols released by the surgical staff from causing postoperative infection of the patient; and (ii) protecting the surgical team against infection by bacteria from the wound site. seven cases of computer simu ... | 2005 | 15620448 |
| residues of ddts, pahs and some heavy metals in fish (tilapia) collected from hong kong and mainland china. | most of the freshwater fish consumed in hong kong is imported from the southern part of china, although hong kong also produces a small amount of freshwater fish. the major aim of the present study was to conduct a health risk assessment of fish produced from the mainland (purchased from four local markets in hong kong) compared with those produced from hong kong fishponds. thirty tilapia fish (tilapia mossambicus) were collected from the fishponds at tam kon chau, nam sang wai, and mai po natur ... | 2005 | 16287644 |
| numerical analysis of electrophoretic periplasmic protein patterns of aeromonas sp. strains. | a total of 103 strains of aeromonas spp. isolated from clinical and from environmental samples was compared by using sds-page of periplasmic proteins patterns. strains isolated from polish children suffering from gastroenteritis did not appear similar to strains isolated from human living in hong-kong. aeromonas sp. strains did not show a tendency to cluster according to their origin. our results have demonstrated no species-specific periplasmic protein profiles. a significant protein electropho ... | 2005 | 16209101 |
| the clinical outcome of 137 rape victims in hong kong. | from 1 august 2001 to 31 july 2004, 137 patients were referred from the association concerning sexual violence against women to the accident and emergency department at the kwong wah hospital for alleged rape. approximately half of the patients presented within 3 days of the alleged assault. fifty-one patients were prescribed emergency contraception: one patient remained pregnant despite treatment and was referred with a further six patients to the gynaecology department for termination of pregn ... | 2005 | 16219959 |
| a case of human brucellosis in hong kong. | brucellosis is an infectious disease of humans and animals caused by brucella species. we report on a 34-year-old housewife who presented with recurrent headache, fever, and malaise. blood cultures yielded slow-growing gram-negative coccobacilli that were later identified as brucella melitensis. the patient recalled handling goat placenta in china. she was prescribed a 6-week course of doxycycline and rifampicin. laboratory staff who had been exposed to the isolate remained asymptomatic. the epi ... | 2005 | 16219962 |
| vibrio vulnificus peritonitis after handling of seafood in a patient receiving capd. | vibrio vulnificus is a marine bacterium and opportunistic human pathogen. associated infections have contributed to the majority of seafood-related deaths in the united states. in patients with such predisposed clinical conditions as chronic liver disease, immunocompromised state, and end-stage renal disease, this organism has been associated with the development of life-threatening primary septicemia and severe wound infection. however, continuous ambulatory peritonitis dialysis (capd)-related ... | 2005 | 16253715 |
| human infection by avian influenza a h5n1. | the southeast asian outbreak of the highly lethal avian influenza a h5n1 infection in humans is unlikely to abate because of the enormous number of backyard farms providing poultry as the main source of food protein in developing countries. this increases the risk of the emergence of a reassortant pandemic influenza virus with improved human-to-human transmissibility. currently triage of suspected cases by epidemiological risk factors remains the only practical way of case identification for lab ... | 2005 | 15951584 |
| multinational impact of the 1968 hong kong influenza pandemic: evidence for a smoldering pandemic. | the first pandemic season of a/h3n2 influenza virus (1968/1969) resulted in significant mortality in the united states, but it was the second pandemic season of a/h3n2 influenza virus (1969/1970) that caused the majority of deaths in england. we further explored the global pattern of mortality caused by the pandemic during this period. | 2005 | 15962218 |
| [digenic association of rho and rp1 genes with retinitis pigmentosa among chinese population in hong kong]. | to identify the mutation patterns of rho and rp1 genes in the chinese patients with retinitis pigmentosa (rp) and to explore their potential interactions in the pathogenesis of rp. | 2005 | 16185528 |
| identification of hepatitis b virus x gene mutation in hong kong patients with hepatocellular carcinoma. | chronic infection by hepatitis b virus (hbv) is the leading cause of hepatocellular carcinoma (hcc) in man. the viral transactivator hbv x (hbx) gene plays a critical role in the molecular pathogenesis of hbv-related hcc. | 2005 | 16087118 |
| three dimensions of the survival curve: horizontalization, verticalization, and longevity extension. | three dimensions of the survival curve have been developed: (1) "horizontalization," which corresponds to how long a cohort and how many survivors can live before aging-related deaths significantly decrease the proportion of survivors; (2) "verticalization," which corresponds to how concentrated aging-related ("normal") deaths are around the modal age at death (m); and (3) "longevity extension," which corresponds to how far the highest normal life durations can exceed m. our study shows that the ... | 2005 | 15986985 |
| polychlorinated biphenyls and organochlorine pesticides in human adipose tissue and breast milk collected in hong kong. | contamination from persistent organic pollutants is a pervasive global problem that urgently demands global concern and action. in the present study, concentrations of organochlorine (oc) pesticides and polychlorinated biphenyls (pcbs) were determined in 37 samples of female adipose tissue collected in hong kong hospitals. among the pollutants analyzed, ddts (2.79 ng/g fat), hchs (0.72 ng/g fat), and pcbs (0.19 ng/g fat) were prominent compounds in most of the adipose tissue. p,p'-dde and hexach ... | 2005 | 16001156 |
| organochlorines and dioxin-like compounds in green-lipped mussels perna viridis from hong kong mariculture zones. | concentrations of persistent organic pollutants including polychlorinated biphenyls (pcbs), organochlorine (oc) pesticides and dioxin-like compounds were measured in green-lipped mussels, perna viridis, collected from seven mariculture zones in hong kong between september and october in 2002 in order to evaluate the status, spatial distribution and potential sources of pollution in these areas. concentrations ranged from 300 to 4400 ng/g lipid weight for total ocs and 170-1000 ng/g lipid weight ... | 2005 | 16023147 |
| a new haplotype of pdcd1 is associated with rheumatoid arthritis in hong kong chinese. | the programmed death 1 (pd-1) molecule is a negative regulator of t cells, and a genetic association between pd-1 and systemic lupus erythematosus and rheumatoid arthritis (ra) in caucasians has been reported. the aim of this study was to investigate the association of pdcd1 polymorphisms and haplotypes with ra in the chinese population. | 2005 | 15818672 |
| human coronavirus nl63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in hong kong, china. | human coronavirus nl63 (hcov-nl63) is a recently discovered human coronavirus found to cause respiratory illness in children and adults that is distinct from the severe acute respiratory syndrome (sars) coronavirus and human coronaviruses 229e (hcov-229e) and oc43 (hcov-oc43). | 2005 | 15909257 |
| characterization of a bacillus anthracis isolate causing a rare case of fatal anthrax in a 2-year-old boy from hong kong. | we used multiple-locus variable-number tandem repeat analysis (mlva) and paga sequencing to genotype a bacillus anthracis isolate from a fatal case of human anthrax in hong kong. the isolate has a unique mlva genotype, is related to the sterne and ames strains, and is consistent with genotypes identified in china. | 2005 | 15815041 |
| the sars epidemic in hong kong--a human calamity in the 21st century. | this paper reviews the epidemiology and control measures of the sars epidemic in hong kong. it sets out proposals for better preparedness to tackle the disease in future. | 2005 | 15924195 |
| norovirus contamination found in oysters worldwide. | noroviruses (norwalk-like viruses) are recognized as major causes of acute gastroenteritis worldwide. outbreaks of norovirus gastroenteritis are often associated with consumption of oysters. in this study, oysters imported into hong kong from 11 countries over a 3-year period were screened by rt-pcr. overall, 53 out of 507 (10.5%) samples were positive for norovirus-rna, and a wide variety of strains were found. two novel genetic clusters were detected, which could indicate novel human or animal ... | 2005 | 15977231 |
| chromosomal abnormalities and fmr1 gene premutation in chinese women with premature menopause. | to study the prevalence of chromosomal abnormalities and fmr1 gene premutation in chinese women with premature menopause in hong kong. | 2005 | 16085940 |
| cytogenetic analysis of patients with primary and secondary amenorrhoea in hong kong: retrospective study. | to estimate the incidence and type of chromosomal abnormalities in patients with primary and secondary amenorrhoea in hong kong. | 2005 | 16085943 |
| near-miss errors in laboratory blood test requests by interns. | human errors have proven to be one of the most formidable patient care challenges in acute hospital setting. | 2005 | 16126739 |
| factors affecting the maintenance stable warfarin dosage in hong kong chinese patients. | multiple factors can affect the anticoagulation effect of warfarin. the objective of this study was to determine the relationship between different clinical factors and outcomes of warfarin therapy in hong kong chinese patients. | 2005 | 16133893 |
| association of vitamin k epoxide reductase complex 1 (vkorc1) variants with warfarin dose in a hong kong chinese patient population. | to evaluate the association of vkorc1 genetic variants with warfarin dose requirements in a hong kong chinese patient population. | 2005 | 16141794 |
| human parainfluenza virus 4 outbreak and the role of diagnostic tests. | owing to the difficulties in isolating the virus and the lack of routine surveillance, the clinical significance of human parainfluenza virus 4 (hpiv-4) is less well defined than that of the other human parainfluenza viruses. we describe the first outbreak of hpiv-4 infection in a developmental disabilities unit, involving 38 institutionalized children and three staff members, during a 3-week period in autumn 2004. most subjects had upper respiratory tract infections (urti), while lower respirat ... | 2005 | 16145100 |
| unusual cases of human myiasis due to old world screwworm fly acquired indoors in hong kong. | myiasis is the infestation of tissue by the larvae of flies. we report eight cases of human myiasis in hong kong. all patients were nursing home residents with an average age of 81.8 years. seven patients were bedridden with advanced dementia. four patients had pre-existing wounds. five had poor oral hygiene and four of those were on tube feeding. all of the five patients with poor oral hygiene suffered from oral myiasis. two patients had vaginal infestations and one had wound myiasis in his dia ... | 2005 | 16154168 |
| severe acute respiratory syndrome coronavirus-like virus in chinese horseshoe bats. | although the finding of severe acute respiratory syndrome coronavirus (sars-cov) in caged palm civets from live animal markets in china has provided evidence for interspecies transmission in the genesis of the sars epidemic, subsequent studies suggested that the civet may have served only as an amplification host for sars-cov. in a surveillance study for cov in noncaged animals from the wild areas of the hong kong special administration region, we identified a cov closely related to sars-cov (ba ... | 2005 | 16169905 |
| a survey of attitudes toward homosexuality in hong kong chinese medical students. | homosexuality is now considered an alternative lifestyle occurring with some regularity as a variant of human sexuality, rather than a pathological disorder. it is important to understand the attitudes of medical professionals toward homosexuality, as their attitudes may influence their approach to gay men and lesbians as patients. it is also important to understand the current attitudes of medical students who will be the future generation of health care providers. | 2005 | 16197321 |
| hong kong: court says laws criminalizing sexual activity infringe rights of gay men. | on 24 august 2004, the hong kong court of first instance declared four sections of hong kong's crimes ordinances to be inconsistent with the rights of gay men as set out in hong kong's basic law and bill of rights. | 2005 | 16544417 |
| transforming growth factor-beta1 gene polymorphism in renal transplant recipients. | cytokine transforming growth factor (tgf) is involved in regulation of tissue repair after injury. more recently, tgf-beta1 codon 10 gene polymorphism has been shown to be associated with circulating tgf-beta levels. we tested whether tgf-beta1 genotype polymorphism was predictive of renal allograft function decline. | 2005 | 16350816 |
| hong kong battens down the hatches. | 2005 | 16365938 | |
| human embryo cloning prohibited in hong kong. | since the birth of dolly (the cloned sheep) in 1997, debates have arisen on the ethical and legal questions of cloning-for-biomedical-research (more commonly termed "therapeutic cloning") and of reproductive cloning using human gametes. hong kong enacted the human reproductive technology ordinance (cap 561) in 2000. section 15(1)(e) of this ordinance prohibits the "replacing of the nucleus of a cell of an embryo with a nucleus taken from any other cell," i.e., nucleus substitution. section 15(1) ... | 2005 | 16331533 |
| stiff child syndrome with mutation of dyt1 gene. | the authors report a chinese boy with a dyt1 gene mutation having muscle stiffness, severe painful muscle spasm, myoclonus, and dystonia compatible with stiff child syndrome. autoantibodies to glutamic acid decarboxylase (anti-gad) were absent. his asymptomatic mother had a dyt1 mutation. his asymptomatic sister has diabetes mellitus and antibodies to glutamic acid decarboxylase but no dyt1 mutation. | 2005 | 16275837 |
| avian influenza: risk, preparedness and the roles of public health nurses in hong kong. | this paper provides an overview of the hong kong government's influenza preparedness plan and the key roles of public health nurses in that plan. the part played by hong kong public health nurses in the management of the avian influenza outbreak in hong kong in 1997 and the sudden acute respiratory syndrome outbreak in 2003, together with the capacity-building work they are now undertaking in preparing for an influenza pandemic, highlight their crucial role in public health. recent strengthening ... | 2006 | 16494661 |
| allele frequencies and haplotypes of 12 y-str loci for the local chinese population in hong kong. | haplotype frequencies were established for 12 y-chromosome str loci, including all loci recommended by scientific working group on dna analysis methods y-str subcommittee (dys391, dys389i/ii, dys439, dys393, dys390, dys385a/b, dys438, dys19 and dys392) plus dys437, in the local chinese population in hong kong. in a sample of 481 unrelated males, it was possible to define 424 different haplotypes of which 388 were unique, 26 was found in two individuals, 2 were shared in three individuals, 5 were ... | 2006 | 16876356 |
| photorealistic virtual anatomy based on chinese visible human data. | virtual reality based learning of human anatomy is feasible when a database of 3d organ models is available for the learner to explore, visualize, and dissect in virtual space interactively. in this article, we present our latest work on photorealistic virtual anatomy applications based on the chinese visible human (cvh) data. we have focused on the development of state-of-the-art virtual environments that feature interactive photo-realistic visualization and dissection of virtual anatomical mod ... | 2006 | 16506219 |
| association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17. | genome scan in chinese revealed an association of blood pressure with the microsatellite marker d17s1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (aoms2) at 17p12 on chromosome 17. we previously reported that d17s1303 was associated with hypertension and obesity. therefore, we studied 10 single nucleotide polymorphisms (snp) within 3 kb of d17s1303. one hundred and eighty hypertensive subjects (91 men, 89 women, age 53+/-12 years) and 180 normotensiv ... | 2006 | 16511504 |
| risk assessment of heavy metal contamination in shrimp farming in mai po nature reserve, hong kong. | an ecological survey was carried out to determine the sediment concentrations of nutrients and heavy metals and bioaccumulation of heavy metals in fish and shrimp including tilapia (oreochromis mossambicus x o. nilotica), grey mullet (mugil cephalus), gei wai shrimp (metapenaeus ensis) and caridean shrimp (macrobrachium nipponensis) in the traditional tidal shrimp ponds (gei wais) of mai po nature reserve, hong kong. the sediments collected from the landward sites contained higher nutrient conte ... | 2006 | 16528597 |
| detection of hong kong 97-like h5n1 influenza viruses from eggs of vietnamese waterfowl. | three h5n1 influenza viruses were isolated from shell washes of duck and goose eggs confiscated from travelers coming from vietnam. all eight gene segments of these viruses share high sequence identity with the h5n1 avian influenza viruses that caused outbreaks in poultry and humans in hong kong in 1997. animal studies indicate that these isolated viruses are able to replicate in mouse lung and could be found in the organs of ducks without causing any clinical signs or death. however, the viruse ... | 2006 | 16532371 |
| the large 386-nt deletion in sars-associated coronavirus: evidence for quasispecies? | the severe acute respiratory syndrome-associated coronavirus (sars-cov) is reported to have deletions of various sizes. recently, the large 386-nucleotide deletion (l386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from hong kong. in this study, archived specimens from 71 patients with sars who were admitted to the new territory east cluster hospitals in hong kong were analyzed to determine whether t ... | 2006 | 16941348 |
| avian influenza (h5n1): implications for intensive care. | as influenza a/h5n1 spreads around the globe the risk of an epidemic increases. | 2006 | 16568274 |
| demographic and lifestyle factors associated with dioxin-like activity (calux-teq) in human breast milk in hong kong. | maternal exposure to dioxins and related compounds before conception may affect the health of the fetus. to identify factors affecting dioxin body load in hong kong, in 2002, total dioxin-like activity was estimated in 250 individual milk samples at 2-6 weeks postpartum, from a representative group of primiparous mothers, aged 18-42 years (mean 29 +/- 5 years), by a chemically activated luciferase expression (calux) bioassay. associations between the calux-teq and 20 socio-demographic and dietar ... | 2006 | 16568753 |
| health professionals and the international code of marketing of breast-milk substitutes. | 2006 | 17028365 | |
| validating crash locations for quantitative spatial analysis: a gis-based approach. | in this paper, the spatial variables of the crash database in hong kong from 1993 to 2004 are validated. the proposed spatial data validation system makes use of three databases (the crash, road network and district board databases) and relies on gis to carry out most of the validation steps so that the human resource required for manually checking the accuracy of the spatial data can be enormously reduced. with the gis-based spatial data validation system, it was found that about 65-80% of the ... | 2006 | 16574045 |
| bird flu prevention. | 2006 | 16631878 | |
| social competence as a positive youth development construct: conceptual bases and implications for curriculum development. | two major aspects of social competence were studied in this section: positive human relationships and clear self-identity. the concepts of human relationships and identity development are delineated. the importance of the development of a national identity for hong kong adolescents is also explained. the social competence program units focus on issues relating to national and racial identity, and human relationships (especially the resolution of interpersonal conflicts in the family and between ... | 2006 | 17068919 |
| human capital, social capital and social exclusion: impacts on the opportunity of households with youth to leave poverty. | based on a sample survey, this paper, analyzes the impact of human capital, social capital and social exclusion on the opportunity of hong kong families with youth members to leave poverty. educational attainment of the youth members and adult family members, as well as the quantity and quality of social networks were found to have significant positive impacts, while social exclusion from the labor market of the adult members was found to have significant negative impact on their opportunity to ... | 2006 | 17068934 |
| evaluation of the effect of energy conservation techniques in the performance of activity of daily living tasks. | to determine whether energy conservation techniques during common activity of daily living tasks actually result in lower energy expenditure, and to document subjective comments regarding any differences in the perceived level of effort. | 2006 | 16634345 |
| an evaluation of nursing practice models in the context of the severe acute respiratory syndrome epidemic in hong kong: a preliminary study. | like other health-care workers, hong kong nurses had their professional knowledge and skills seriously challenged during the sars outbreak. could current nursing practices support the care of sars or sars-like patients in the future? if not, alternative practices would be needed. providing a preliminary understanding, this paper compares the conventional with different nursing delivery models in a simulated sars ward and focuses on nurses' efficiency, infection control practices and views of the ... | 2006 | 16684161 |
| hla-b67 may be a male-specific hla marker of susceptibility to relapsed childhood all in hong kong chinese and hla-a33 or hla-b17 signifies a higher presentation leukocytosis: a retrospective analysis on 53 transplant candidates (1989-2003). | we performed a retrospective analysis on the human leukocyte antigen (hla) data of 53 consecutive chinese patients with high-risk childhood acute lymphoblastic leukemia (all) diagnosed from 1989 to 2003. a significantly higher frequency of hla-b67 in the male relapse group of patients [or, 23.08; 95% ci, 5.31-100.36; p = 0.0042; for statistical significance after bonferroni correction (bc) p (bc) < 0.0083] was identified after bonferroni correction. although not surviving the bonferroni correcti ... | 2006 | 16710717 |
| influenza-related deaths and hospitalizations in hong kong: a subtropical area. | while influenza vaccination has been widely used in developed countries to reduce mortality and morbidity in high-risk populations, the lack of regional data on the health burden of influenza and the uncertainty of the applicability of data from temperate areas have been major impediments to establishing an evidence-based policy on the wider use of influenza vaccine in tropical and subtropical regions of the world. | 2006 | 16713608 |