Publications

haemophilus influenzae associated with acute respiratory illnesses in young children.		1980	6985292
haemophilus influenzae associated with acute respiratory illnesses in young children.		1980	6985456
hemophilus influenzae infections: a brief review.	invasive disease due to hemophilus influenzae constitutes a major pediatric problem. the present article summarizes current concepts regarding epidemiologic, diagnostic, preventive and therapeutic aspects of hemophilus influenzae infections.	1980	6985853
rapid biochemical characterization of haemophilus species by using the micro-id.	biotyping of haemophilus influenzae into five type and h. parainfluenzae into three types based on indole production, ornithine decarboxylase, and urease has been reported (m. kilian, acta pathol. microbiol. scand. sect. b 82:835--842, 1976). a commercially available test system designed for the 4-h identification of enterobacteriaceae. micro-id, proved efficacious for the rapid biotyping of these two haemophilus species. the nitrate reductase, indole production, ornithine decarboxylase, urease, ...	1980	6986401
clinical pharmacology of two chloramphenicol preparations in children: sodium succinate (iv) and palmitate (oral) esters.	the clinical pharmacology of chloramphenicol was evaluated in 14 children with serious bacterial infections. the children received chloramphenicol sodium succinate intravenously for five to six days at which time orally administered chloramphenicol palmitate was substituted for an additional five to six days of therapy. the mean peak serum chloramphenicol concentration when given iv (28.2 +/- 5.1 micrograms/ml) occurred within one hour after the termination of the 60-minute iv infusion and when ...	1980	6987361
plasmids and antibiotic resistance in gram-negative bacteria.		1980	6987459
[biochemical characterization of haemophilus strains with a standardized micromethod (author's transl)].	using a standardized micromethod, the authors aimed at the study of biochemical characterization of 51 haemophilus strains (influenzae and parainfluenzae). the statistical analysis of the results allowed them to definite a theoretical average outline corresponding to three groups of bacteria :-- group of haemophilus influenzae, -- group of haemophilus parainfluenzae, -- group of different haemophilus. the authors propose some modifications in order to make this identification specifically applic ...	1980	6988783
haemophilus influenzae septic arthritis in adults.	the incidence of haemophilus influenzae infections appears to be increasing although disease in adults due to this organism remains unusual. only 16 cases of septic arthritis caused by this agent were found in a review of the literature. two additional cases are reported and a summary of the clinical characteristics of these patients is presented. in general, females are affected more commonly than males, and blacks more often than whites. joint involvement may be single or multiple, and associa ...	1980	6989242
study of the chronic toxicity of d 53 by aerosol. one-year observation.		1980	6989375
specific proteolysis of human iga by streptococcus pneumoniae and haemophilus influenzae.	streptococcus pneumoniae and haemophilus influenzae are among the most common bacterial pathogens responsible for respiratory tract infections in otherwise healthy humans. thirty-six strains of s. pneumoniae, 62 strains of h. influenzae, six hospital-acquired respiratory pathogens, and a strain of streptococcus pyogenes were examined for production of iga protease, a bacterial enzyme whose only known substrate is human iga1. iga protease was produced by 100% of the isolates of s. pneumoniae and ...	1980	6989925
[drug sensitivity of bacteria isolated from clinical samples (author's transl)].		1980	6990050
the effect of polyvalent pneumococcal polysaccharide vaccine on nasopharyngeal and nasal carriage of streptococcus pneumoniae.	to investigate the possible effect of a polyvalent pneumococcal vaccine on the nasopharyngeal and nasal carriage of streptococcus pneumoniae, we studied 313 children under 8 years of age who had received either 14-valent pneumococcal capsular polysaccharide vaccine (pn) or haemophilus influenzae type b capsular polysaccharide vaccine (hib) after having recovered from acute otitis media. nasopharyngeal and nasal swabs were obtained during a symptomless phase, 6 to 12 months after the vaccination, ...	1980	6990475
cellular fatty acid composition of haemophilus species, pasteurella multocida, actinobacillus actinomycetemcomitans and haemophilus vaginalis (corynebacterium vaginale).	the fatty acid composition of 35 haemophilus influenzae strains was found to be grossly similar and characterized by relatively large amounts of 14:0, 3-oh-14:0, 16:1 and 16:0. the three c18 fatty acids 18:2, 18:1 and 18:0 were also present, but in much lower concentrations. this general pattern was also found for most of the other species of haemophilus examined (h. aegyptius, h. aphrophilus, h. canis, h. gallinarum, h. haemolyticus, and h. parainfluenzae). small but distinct quantitative discr ...	1980	6990689
anaerobic and aerobic bacterial flora of acute conjunctivitis in children.	aerobic and anaerobic cultures and clinical data were obtained from 126 pediatric patients with acute conjunctivitis. similar cultures were obtained from 66 persons who did not have a conjunctival inflammation. anaerobes were isolated from 47 patients (37.3%). in 26 cases (20.6%), they were in mixed cultures with aerobes, and in 21 cases (16.7%), they were the only isolates. aerobes alone were recovered in 72 patients (57.1%). no bacterial growth was noted in seven patients (5.6%). the organisms ...	1980	6990902
[studies on an extract from haemophilus influenzae type a. ii.--phagocytic capacity of sera obtained from rabbits immunized by this bacterial extract (author's transl)].	opsonins may protect against infections. in this study, the different parameters of opsonization assay are strictly standardized. results are expressed as percentage of opsonization. 0% and 100% opsonization must be established. the experiment without immunserum is used as the 0% opsonization. to determine the 100% opsonization an excess of reducing capacity is required. this is provided by crushed leukocytes. rabbits are immunised by bacterial extract from haemophilus influenzae type a. the hem ...	1980	6992066
[significance of precipitating antibodies to bacterial antigens in the blood in chronic pneumonia].		1980	6992138
gr-20263: a new aminothiazolyl cephalosporin with high activity against pseudomonas and enterobacteriaceae.	the in vitro activity of gr-20263, a new aminothiazolyl cephalosporin, was compared with the activities of other beta-lactam antibiotics by using 800 clinical bacterial isolates. gr-20263 was highly active (inhibition of 90% of the isolates between 0.03 and 1 microgram/ml) against the common enterobacteriaceae and 5 to 20 times more active than cefuroxime, cefoxitin, and cephalothin. gr-20263 was three to six times less active than cefotaxime against escherichia coli, klebsiella pneumoniae, salm ...	1980	6994640
indirect enzyme-linked immunosorbent assay for the quantitation of the type-specific antigen of haemophilus influenzae b: a preliminary report.	infections with haemophilus influenzae type b are major causes of morbidity and mortality in young children. we developed an enzyme-linked immunosorbent assay for the diagnosis of hib infections. the elisa was more sensitive than both counterimmunoelectrophoresis and latex agglutination for the detection of hib antigen in serum, urine, and cerebrospinal fluid. in addition, no false positive elisa reactions were noted. the increased sensitivity of elisa was especially valuable in the detection of ...	1980	6995567
meningitis caused by gram-negative bacilli.	thirty adults with meningitis caused by gram-negative bacilli were observed from 1968 to 1978 at four hospitals associated with boston university school of medicine. equal numbers of two distinct types of gram-negative bacillary meningitis--spontaneously occurring meningitis and meningitis after neurosurgery--were found. spontaneously occurring meningitis appeared to be caused most often by escherichia coli and haemophilus influenzae. meningitis occurring after neurosurgical procedures was more ...	1980	6996552
hearing alterations following meningitis. 1. hearing improvement.	in ten patients suffering from hearing loss following meningitis or meningoencephalitis, hearing recovery was observed. eight of the cases had suffered from purulent meningitis, five cases had haemophilus influenzae meningitis, 1 had coli meningitis, and 1 had meningococcal meningitis. in one case, the ethiologic agent remained unknown. two other cases had suffered from viral meningoencephalitis. postmeningitis hearing loss was observed in 19 ears. in eight ears, the hearing loss was profound, a ...	1980	6997117
evaluation of the four-hour micro-id technique for direct identification of oxidase-negative, gram-negative rods from blood cultures.	a 4-h micro-id technique for direct identification of oxidase-negative gram-negative rods from positive blood cultures was compared to subculture and species identification of single colonies by api 20e and micro-id, using standardized inocula. a total of 127 patients (220 positive cultures) were studied. isolates included 96 escherichia coli, 46 klebsiella pneumoniae, 7 klebsiella oxytoca, 8 enterobacter aerogenes, 17 enterobacter cloacae, 19 serratia marcescens, 2 serratia liquefaciens, 8 prot ...	1980	6999020
counterimmunoelectrophoresis for early detection and rapid identification of haemophilus influenzae type b and streptococcus pneumoniae in blood cultures.	counterimmunoelectrophortesis was shown to be a sensitive method for rapid detection of pneumococcal and haemophilus influenzae type b antigens in blood cultures.	1980	6999027
use of monoclonal antibodies in an enzyme-linked inhibition assay for rapid detection of streptococcal antigen.	we have developed an enzyme-linked monoclonal antibody inhibition assay to detect bacterial antigens in cerebrospinal fluid. the monoclonal antibody used in this immunodiagnostic test was produced by continuous cultures of hybrid myeloma cell lines. using this assay, type iii gbs antigen was detected in csf specimens from 11 culture-proven cases of gbs meningitis and in the knee aspirate from an infant with gbs septic arthritis. five spinal fluid specimens from meningitis due to other bacterial ...	1980	6999140
[thiamphenicol versus trimethoprim-sulfamethoxazole in bacterial exacerbations of chronic unspecific respiratory tract diseases. a controlled study].	to document the efficacy of trimethoprim-sulfamethoxazole (tmp-smz) in treating bacterial exacerbations of chronic bronchitis, and to evaluate the efficacy of thiamphenicol (tap), 29 patients with chronic bronchial disease were treated for two separate bacterial exacerbations, once with 0.48 g of tmp and 2.4 g smz daily, and once with 1.5 g of tap daily, for 14 days. patients were evaluated weekly and different measurements, including graded clinical observations, ventilatory tests, sputum measu ...	1980	6999618
newer knowledge in classification, taxonomy and pathogenicity of species in the genus haemophilus. a critical review.	this critical review deals with our present knowledge on the classification, taxonomy and pathogenicity of the different species of the genus haemophilus occurring in humans and animals, including the five biotypes of h. influenzae and the 3 biotypes of h. para-influenzae. the first, second, third and fourth stage tests for differentiation of the species are summarized in several tables.	1980	6999796
latex agglutination test for rapid detection of bacterial antigens in body fluids.	a modified latex agglutination (la) test performed on glass slides was evaluated for the detection of streptococcus pneumoniae (pn), hemophilus influenzae type b (hib), and k1 antigens in serum, cerebrospinal fluid (csf), nasopharyngeal secretions, and other body fluids in patients suspected of having infection. forty-eight, 61, and 31 specimens were tested for the presence of pn, hib, and k1 antigens, respectively, by countercurrent immunoelectrophoresis (cie) and la. of the specimens positive ...	1980	6999972
enzyme-linked immunosorbent assay for detection of haemophilus influenzae type b antigen.	an enzyme-linked immunosorbent assay for the detection of haemophilus influenzae type b antigen was developed. it was able to detect purified polyribose phosphate at concentrations of greater than or equal to 1 ng/ml in cerebrospinal fluid. this was 50 times more sensitive than counterimmunoelectrophoresis with the same antiserum. the sensitivity for polyribose phosphate in urine was similar, but that in serum was about 10 times less. nonspecific reactions were observed with blood-stained cerebr ...	1980	7000809
indirect sandwich enzyme-linked immunosorbent assay for rapid detection of streptococcus pneumoniae type 3 antigen.	an indirect sandwich enzyme-linked immunosorbent assay for the detection of the polysaccharide antigen of type 3 pneumococcus (sss-iii) is reported. polystyrene balls with attached anti-sss-iii antibody serve as the solid phase, and antigen is detected using an alkaline phosphatase-labeled antiglobulin conjugate. the reaction is quantitated by spectrophotometry. concentrations of antigen are estimated by comparison with standard curves prepared with purified sss-iii. for this assay, the practica ...	1980	7000815
spread of haemophilus influenzae type b: recent epidemiologic and therapeutic considerations.		1980	7000999
immunoglobulin production in man stimulated by an orally administered bacterial lysate.	the concentrations of secretory immunoglobulins in the saliva, and of immunoglobulin in the serum, have been measured by the radial immunodiffusion method in 12 healthy volunteers, before and after oral administration of broncho-vaxom which is a lysate of bacteria that usually cause infection in the upper respiratory tract. the mean concentration of secretory iga in the saliva was increased by over 100% after the 10-day administration of the product. this increase was statistically significant b ...	1980	7003667
advances and controversies in the management of supraglottitis and laryngotracheobronchitis.	recent advances in pediatric airway intubation and the introduction of pharmacotherapeutic agents, active within the larynx and tracheobronchial tree, have created significant controversies in the treatment of acute obstructive inflammatory laryngeal disease. although the etiology, pathophysiology, and clinical patterns of supraglottitis and laryngotracheobronchitis are no longer confused, decisions concerning their medical management and method of airway control remain controversial. both infla ...	1980	7004221
high isolation rate of branhamella catarrhalis from the nasopharynx in adults with acute laryngitis.	branhamella catarrhalis was isolated from the nasopharynx in 55% of 40 noncompromised adult patients suffering from acute laryngitis. diplococcus pneumoniae and haemophilus influenzae were found in another 5 and 8%, respectively; one patient had group a streptococci in the throat specimen. in 90% of the patients the laryngitis complaints were preceded by symptoms of an acute respiratory tract infection. two of the patients with b. catarrhalis showed a significant titre conversion against influen ...	1980	7006061
[haemophilus influenzae in 1980: clinical, microbiological and therapeutic aspects. a review].		1980	7006179
primary gram negative pneumonia in adults in papua new guinea.	a retrospective review of gram-negative bacteraemia in papua new guinean adults revealed four cases of primary gram negative pneumonia over a two-year period. patients with primary gram negative pneumonia constituted less than 1% of all pneumonias admitted to the medical ward. pseudomonas pseudomallei, haemophilus influenzae and klebsiella pneumoniae were the aetiologic agents. three of four patients died following a fulminant course. it is concluded that primary gram-negative pneumonia in papua ...	1980	7008428
acute epiglottitis in children.	hemophilus influenzae type b (30 cases), untyped (two cases), and type a (one case), and h parainfluenzae (one case) were recovered in blood cultures from 44 cultures of 53 children with acute epiglottitis. these patients were managed by observation, tracheotomy, or intubation, with intubation being the most satisfactory. both ampicillin and chloramphenicol have been employed recently because of the emergence of ampicillin resistance, which was 18.7% of all cases in 1977.	1980	7010270
clinical experience with cefamandole in pneumonia.	the efficacy and patient acceptance of i.m. cefamandole 1 000 mg 8 h and 500 mg 8 h, were compared in the treatment of assumed community-acquired pneumonia in 59 hospitalized adult patients. of 31 patients treated with 1 000 mg 8 h, 94% had a satisfactory clinical response with a 13% bacteriological failure rate. of 28 patients treated with 500 mg 8 h, 89% had a satisfactory clinical response with a 60% bacteriological failure rate. the only side effect registered was pain at the injection site ...	1980	7010534
cefamandole treatment of pulmonary infection caused by gram-negative rods.	the increasing incidence of pneumonia caused by h. influenza and the problem of beta lactamase production (18% of strains in recent reports) are important considerations in the therapy of pneumonia. an antibiotic that is effective for these strains and other common respiratory pathogens will be useful for the therapy of pneumonia. cefamandole nafate is a new cephalosporin antibiotic with an antimicrobial spectrum similar to cephalothin with increased activity against escherichia coli, proteus sp ...	1980	7010535
cefamandole in the treatment of serious bone and joint diseases.	the safety and efficacy of treatment with cefamandole were evaluated in 77 patients (from 33 institutions) with serious bone and joint infections. the antibiotic was given intramuscularly or intravenously in doses ranging from 1.5 to 12 g/day for 6 to 58 days. seventy-three of the 77 patients responded satisfactorily, and 63 (of 70 from whom material for culture was obtainable) patients had a bacteriologic cure. forty-one of 81 isolates were identified as staphylococcus aureus. other pathogens i ...	1980	7010542
enzyme-linked immunosorbent assay for titration of haemophilus influenzae capsular and o antigen antibodies.	the enzyme-linked immunosorbent assay (elisa) was elaborated for the detection of immunoglobulin m (igm) and igg antibodies against capsular and o antigens of haemophilus influenzae. purified capsular polysaccharide and lipopolysaccharide were used as antigens, with optimal coating concentrations being about 50 and 100 micrograms/ml, respectively. the antibody content was expressed as the highest serum dilution (-log10) showing an absorbance of 0.2 above the background level. the titers of hyper ...	1980	7014605
[drug sensitivity of bacteria isolated from clinical samples. ii. (author's transl)].		1980	7017193
[difference in photoreactivation of dna inactivated by ultraviolet light or near-ultraviolet light].		1980	7027391
phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.	dipeptide variants of alafosfalin (l-alanyl-l-1-aminoethylphosphonic acid) with substantial differences in potency and antibacterial spectrum in vitro and in vivo have been synthesized. certain dipeptides with alternatives to the l-alanyl residue had broader antibacterial spectra; activity against pseudomonas aeruginosa was included. some compounds had better in vivo activity than alafosfalin when introduced into infected rodents orally, but for the majority of the more active phosphonodipeptide ...	1980	7016027
[pharmakokinetic and clinical studies with azlocillin in paediatrics (author's transl)].	azlocillin, an acylureido penicillin with bactericidal activity, is particularly effective against pseudomonas, enterococci and haemophilus influenzae. it is also very active against e. coli, various proteus species and bacteroides. pharmacokinetic studies were carried out in 138 children of various ages (prematures, newborns, infants, schoolchildren) after administering 50-75-100 mg/kg/ body weight azlocillin via the i.v. or i.m. routes; the constant of elimination and the distribution volumes ...	1980	7192337
the in vitro activity of cefamandole against 3312 bacterial isolates. a norwegian multicentre study.	in a multicentre study the in vitro activity of cefamandole against 3312 bacterial isolates was compared to the antibacterial activity of cephalothin, ampicillin, oxacillin, doxycycline and tobramycin. cefamandole and tobramycin showed the highest activity against the enterobacteriaceae isolates, whereas the staphylococcus aureus isolates were slightly less sensitive to cefamandole than to cephalothin and oxacillin. there was no significant difference between the activity of cephalothin and cefa ...	1980	7219840
[quantitative cytobacteriological study of sputum in chronic bronchitics (author's transl)].	a quantitative cytobacteriological study of sputum was carried out in 259 chronic bronchitics. in non-purulent sputum (leukocyte count lower than 2,000/mm3), flora identified was salivary in 73% of the cases. in purulent sputum (leukocyte count higher than 5 000/mm3), the most frequently identified predominant bacterial species were haemophilus influenzae (20%), pseudomonas aeruginosa (13%) and streptococcus pneumoniae (10.5%). in the most severely ill patients, admitted to the intensive care un ...	1980	7221170
damage and repair in mammalian cells after exposure to non-ionizing radiations. iii. ultraviolet and visible light irradiation of cells of placental mammals, including humans, and determination of photorepairable damage in vitro.	cultured cells of placental mammals (including human skin fibroblasts) as well as fresh cornea tissue from oxen have been uv (254 nm)-irradiated and either kept dark or exposed to photoreactivating light (wavelengths greater than 375 nm only) prior to extraction of their dna. the latter was added to an in vitro photorepair system consisting of uv-irradiated dna from haemophilus influenzae and yeast-photoreactiving enzyme, illuminated with broad-spectrum white fluorescent light. the extent of com ...	1980	7360143
peroperative antibiotics in the prevention of chest infection following cardiac operations.	seventy-nine patients about to undergo cardiac operations were randomly allocated to two treatment groups in an attempt to reduce postoperative chest infections. the group receiving a short peroperative course of cefamandole, an antibiotic effective against both the pneumococcus and haemophilus influenzae, had a significantly lower postoperative chest infection rate than the group receiving a 3-day course of cephradine, an antibiotic previously chosen to prevent intracardiac infection during the ...	1980	7362956
thiamphenicol and chloramphenicol: an in vitro comparison with particular reference to bactericidal activity.	chloramphenicol is bacteristatic for most species but bactericidal for haemophilus influenzae and neisseria meningitidis. despite its generally lower activity, thiamphenicol exhibited equal or greater activity against these two species than did chloramphenicol. it is suggested that a particular place might be defined for thiamphenicol in the treatment of infection due to these two organisms.	1980	7363705
the etiology of bullous myringitis and the role of mycoplasmas in ear disease: a review.	a critical review of the literature concerning bullous myringitis has found one case of possible mycoplasmal, one of possible viral, and 43 of bacterial, etiology. the bacteria were streptococcus pneumoniae, haemophilus influenzae, and beta-hemolytic streptococcus, in the same percentages as found in (nonbullous) otitis media. one of 858 attempts to isolate mycoplasma from cases of (nonbullous) otitis media was successful. the evidence that mycoplasma are a cause of otitis media with or without ...	1980	7367083
ventriculoperitoneal shunt-associated infection due to haemophilus influenzae.	we report two children with ventriculoperitoneal shunt infections due to haemophilus influenzae, type b. one child was cured with systemic and intraventricular antimicrobial therapy alone. the other child had persistently positive ventricular fluid cultures, ultimately required shunt removal in addition to antimicrobial therapy, and still had a relapse, which responded to antimicrobial therapy alone. in treating children with this problem we recommend removal of the shunt apparatus unless there ...	1980	7367112
study of the teratogenic activity of ribosomal vaccine.	the investigation on the possible teratogenic activity of a vaccinal formula of ribosomes of klebsiella pneumoniae, streptococcus pneumoniae, streptococcus pyogenes a12 and haemophilus influenzae (d 53) was carried out in three animal species: rats, mice, rabbits. the trials were performed on two generatins of rats and mice, and on one single generation of rabbits. d 53 was given in s.c. injections (6 days a week) for 8 days before mating the females, and then until the females dropped (or were ...	1980	7370080
spinal cord involvement in acute bacterial meningitis.	a 25-month-old boy had the development of respiratory arrest and quadriplegia with a t-10 sensory level during the acute phase of haemophilus influenzae meningitis. the sequelae of spinal cord involvement of bacterial meningitis are reviewed. a possible mechanism of the spinal cord involvement in this case is discussed with reference to known pathology of h influenzae meningitis.	1980	7370092
fluid management in haemophilus influenzae meningitis.	the fluid management of 50 children with haemohpilus influenzae type b meningitis was reviewed. clinical hydration status on admission, serum sodium values, and overall fluid balance was assessed to determine the contribution of empiric fluid restriction in preventing the development of syndrome of inappropriate antidiuretic hormone (siadh). thirty-three of 50 patients were well hydrated on admission. sixteen of 50 patients (32%) initially had signs of dehydration and five out of 16 were in shoc ...	1980	7372357
anemia with haemophilus influenzae meningitis.	the hematologic values in patients with haemophilus influenzae meningitis were contrasted with those of patients with other types of bacterial meningitis and aseptic meningitis in an attempt to determine whether anemia is either specific for or more common in patients with h influenzae meningitis. patients with h influenzae meningitis had significantly lower admission hemoglobin values because they were significantly younger than the other two groups. the h influenzae meningitis patients with th ...	1980	7375233
influenza virus infection of newborn rats: virulence of recombinant strains prepared from influenza virus strain a/okuda/57.	infant rats were infected intranasally with wild influenza virus strains, attenuated strain a/okuda/57 or recombinants prepared from these parents. the growth of viruses in the turbinates or lungs, and the ability of virus infections to potentiate subsequent bacterial infection by haemophilus influenzae (hib) were measured. the two wild strains of virus and a recombinant strain wrl105, known to be virulent for man, reached titres of 10(5.1)--10(6.5) ebid50/ml in the turbinates of infant rats 48 ...	1980	7381917
chronic otitis media in children. microbiological studies.	aspiration of the exudate through the open perforation was performed in 68 children with chronic otitis media. the middle ear aspirate and a swab specimen of the external auditory canal were cultured aerobically and anaerobically. seventy-eight isolates were recovered from the middle ears, 99 from the external ear canals, and 95 were present at both sites. aerobes only were isolated from 33 patients (48.5%), nine (13.2%) had only anaerobes, and 26 (38%) had a culture that grew both aerobes and a ...	1980	7386427
clinical and pharmacokinetic evaluation of parental cefoxitin in infants and children.	thirty-two infants and children ranging in age from 3 to 151 months (mean, 26 months) were treated with parenteral cefoxitin (150 mg/kg per day). ten patients with isolates of haemophilus influenzae (six with cellulitis, two with arthritis, and two with mastoiditis), four with staphylococcus aureus (one with lymphadenitis, one with septicemia, and two with abscess), and three patients with streptococcus pneumoniae (one each with cellulitis, abscess, and arthritis), were clinically and bacteriolo ...	1980	7396456
chloramphenicol levels in cerebrospinal fluid in meningitis.	chloramphenicol was found to cross the blood-brain barrier into the cerebrospinal fluid of children with pyogenic meningitis effectively both at days 2 and 10 of therapy. it is recommended as the drug of choice in the treatment of children with haemophilus influenzae meningitis.	1980	7404208
activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis.	to compare the in vitro activity of cefamandole with ampicillin, cefoxitin, and gentamicin, each antimicrobial was tested against 419 bacteria isolated from the blood of patients with proved sepsis. cefamandole was active against all gram-positive cocci except the enterococci. most enterobacteriaceae were inhibited by both cefamandole and cefoxitin. cefamandole showed an activity similar to ampicillin against haemophilus influenzae. the percent of blood culture isolated considered susceptible to ...	1980	7408556
sequelae of haemophilus influenzae meningitis.		1980	7425983
disposition of chloramphenicol in low birth weight infants.	although infrequently an antibiotic of first choice for neonates, chloramphenicol (cl) may be indicated in selected instances of infection caused by aminoglycoside-resistant enterobacteriaciae, anaerobes, and ampicillin-resistant haemophilus influenzae. use of cl in neonates has been limited since the recognition that vascular collapse may occur as a consequence of dosage regimens tolerated by adults. with an assay that detects only active cl, we studied drug disposition in 13 low birth weight i ...	1980	7432843
pasteurella multocida meningitis.	pasteurella multocida appears to be a very rare cause of meningitis. the bacterium has morphological similarities with other causative organisms, particularly haemophilus influenzae, and its apparent rarity may be due partly to misidentification. this case, only the fourth reported from the united kingdom, could not be distinuished clinically from the meningitis, owing to other pyogenic bacteria.	1980	7433325
a prospective study on septicemia. ii. clinical manifestations and complications, results of antimicrobial treatment and report of a follow-up study.	in a prospective study at a hospital for infectious diseases 151 patients, 110 with proved and 41 with probable septicemia, were analysed. clinical, laboratory, therapeutic data and prognostic experiences, partly from a follow-up study, are described. secondary manifestations, mostly from skin, mucous membranes, nervous system and lungs, were present in 72%. they were more often caused by gram-positive cocci than by gram-negative baccilli and in some cases not revealed until autopsy. lesions in ...	1980	7433919
plasma and sputum erythromycin concentrations in chronic bronchitis.	plasma and sputum concentrations of erythromycin were measured in 10 patients with chronic bronchitis during an eight-day course of a new formulation of erythromycin stearate. the plasma erythromycin levels compared favourably with the minimal inhibitory concentrations for common respiratory pathogens and indicated adequate gastrointestinal absorption when the drug was taken immediately before food. sputum erythromycin levels were variable and in some patients low or undetectable. measurable spu ...	1980	7434299
meningitis caused by haemophilus influenzae type b.		1980	7441024
comparison of in vitro activity of sch 21420, a gentamicin b derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.	sch 21420 is a new aminoglycoside synthesized from gentamicin b. susceptibility tests with sch 21420, amikacin, gentamicin, netilmicin, sisomicin, and tobramycin were performed on a variety of bacterial species including 44 with known mechanisms of resistance to aminoglycosides. sch 21420 and amikacin had similar effects on all except haemophilus influenzae and neisseria species, which were more susceptible to amikacin. except with some strains of serratia marcescens, the drugs used were bacteri ...	1980	7447410
bactericidal activity of cerumen.	freshly collected cerumen (dry form) suspended at a concentration of 3% in glycerol-sodium bicarbonate buffer showed bactericidal activity against some strains of bacteria tested. this suspension reduced the viability of haemophilus influenzae, escherichia coli k-12, and serratia marcescens by more than 99%, whereas the viability of two pseudomonas aeruginosa isolates, e. coli k-1, streptococcus, and two staphylococcus aureus isolates of human origin was reduced by 30 to 80%. the results support ...	1980	7447422
in vitro antagonism by erythromycin of the bactericidal action of antimicrobial agents against common respiratory pathogens.	ten strains each of staphylococcus aureus, haemophilus influenzae, enterobacter spp., escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, and streptococcus pneumoniae were tested in vitro against erythromycin combined with ampicillin, cefamandole, or gentamicin. antagonism by erythromycin occurred with 47% of the combinations involving strains of s. aureus and to a lesser degree with h. influenzae. synergy occurred most commonly with h. influenzae (27%). the high ...	1980	7235675
frequency-pulsed electron capture gas-liquid chromatography and the tryptophan color test for rapid diagnosis of tuberculous and other forms of lymphocytic meningitis.	a total of 260 samples of cerebrospinal fluid received from egypt, the united states, canada, and south america were examined by frequency-pulsed electron capture gas-liquid chromatography (fpec-glc) for tuberculous and other forms of lymphocytic meningitis. thirty-four of the specimens were culture positive for m. tuberculosis, and four cerebrospinal fluid specimens of herpes meningitis were established by immunological techniques. the compound, 3-(2'-ketohexyl)-indoline, was found in about 60% ...	1980	7229007
mitochondrial dna from oenothera berteriana: purification and properties.	mitochondrial dna (mt-dna) from oenothera berteriana tissue culture cells was isolated and characterized with respect to buoyant density in cscl, melting point, contour length, and restriction fragments.because of the rather long purification procedure very few molecules retained their circularity. only one distinct size class of molecules with a length of 100 kilobases was found. restriction fragments were obtained with the enzymes, restrictionendonuclease i from serratia marcescens, restrictio ...	1980	16661361
beta-lactamase producing haemophilus influenzae.		1980	18748717
inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with unveal melanoma.	the specific cell-mediated immunity of the lymphocytes of eight patients with choriodal malignant melanoma (mm) to four extracts of choroidal mm-associated antigens was tested with the aid of the mif technique. seven of the patients with choroidal mm responded to at least one of the four extracts used, whereas patients with choroidal nevus or carcinoma as well as healthy controls did not respond to any of the mm choroidal extracts. there was no response to iris extracts obtained from the enuclea ...	1980	352988
[quality control in drug therapy].		1980	352986
[drug safety through drug legislation].		1980	352981
justice for the patient and the dentist: quality assurance activities of the w. k. kellogg foundation and the american fund for dental health.		1980	284062
the appearances of common dental diseases on radionuclide bone images of the jaws.	radionuclide images of hospital patients were examined for abnormal areas within the jaws. fourteen of 25 subjects studied showed one or more abnormal image areas, most of which were attributable to common dental lesions revealed by oral examinations. the lesions detectable on images included healing bone sites, periodontal and pulpal disease, residual osteitis and irritations caused by ill-fitting dentures.	1980	284037
[prediction of growth anomalies].		1980	283992
[manufacturing of fluoridated oral hygiene products by the pharmaceutical industry].		1980	283986
[periodontal disease of israel and ismael].		1980	283902
multidrug adjuvant chemotherapy for osteosarcoma: interim report of the southwest oncology group studies.		1980	273477
nuva-fil: a technique for cleft palate appliances.		1980	273459
[modern osteosynthesis in the traumatology of facial bones].		1980	283892
management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst.	asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leukemia following treatment with asparaginase. there was a dramatic response to high flow peritoneal lavage with rapid recovery within 24 hours from a moribund state. the subsequent dev ...	1980	283880
prevention of prematurity in twins.		1980	283781
aspects of illness behavior in patients with facial pain.	results of recent studies have suggested that factors other than clinical signs and symptoms have a significant role in determining whether people seek treatment for perceived facial pain and mandibular dysfunction. the concept of "illness behavior" can be used to investigate this problem. knowledge of a patient's illness behavior patterns helps enable the dentist to understand who seeks care for symptoms of facial pain and mandibular dysfunction; why the care is sought; the meaning of the sympt ...	1980	273635
microstructure and chemical composition of noble alloys for porcelain veneering.		1980	273315
dummy- and finger-sucking habits with special attention to their significance for facial growth and occlusion. 7. the effect of earlier dummy- and finger-sucking habit in 16-year-old children compared with children without earlier sucking habit.		1980	273314
chronobiology of blood pressure.	blood pressure in normal and hypertensive subjects shows circadian variability with the minima during the hours of sleep. the factors influencing blood pressure show circadian variability, in particular, plasma and urinary aldosterone, plasma deoxycorticosterone and urinary sodium (factors implicated in cardiac output), angiotensin ii as measured by plasma renin activity, plasma and urinary epinephrine and norepinephrine, and plasma and urinary prostaglandins of the e series (factors implicated ...	1980	440511
are there schizophrenics for whom drugs may be unnecessary or contraindicated?	this study reports that there are schizophrenics who do relatively well long term without the routine or continuous use of antipsychotic medication. specially selected young males undergoing an acute schizophrenic episode were followed, after hospitalization, for up to three years. while hospitalized they were assigned randomly to either placebo or chlorpromazine treatment. many unmedicated-while-in-hospital patients showed greater long-term improvement, less pathology at follow-up, fewer rehosp ...	1980	352976
cytologic diagnosis of echinococcosis.	an asymptomatic echinococcal cyst of the liver discovered during laparotomy was initially diagnosed by cytologic smears. the case probably represents an aseptic necrosis of the parasitic elements in which the cytologic diagnosis had to be based on the presence of the characteristic echinococcal hooklets alone. subsequent histologic examination of the cyst revealed degenerated scolices, as well as detached hooklets. this paper illustrates the usefulness of cytologic smears in the definitive diagn ...	1980	294763
[oral hygiene and partial dentures].		1980	294734
letter: reactive hypoglycemia: fact or fiction?		1980	1272339
the ultrastructure of the androgenic gland in porcellio scaber later. (terrestrial isopods).	this paper presents the normal ultrastructural features of the androgenic gland in porcellio scaber. it describes the changes in the organelles of its cells through the course of the secretory cycle, which terminates with the regression and destruction of these holocrine glandular cells. as products of this activity, the electron-opaque bodies (granules, lysosomes, agglomerates) and clear substances accumulate in the cytoplasm. with the destruction of the cell membrane, the entire cell content p ...	1980	1000604
[acute renal failure due to severe hyperphosphatemia in acute lymphoblastic leukemia].		1980	294578
dental service decay.		1980	284058
dental implants--their current status.		1980	273649
osteochondroma of the zygomatic arch: report of case.		1980	288891
a study of fractured anterior teeth in a school population.		1980	284025
the right formula for paying an associate.		1980	273556
don't panic! you may have a hidden asset.		1980	273552