Publications

immunogenic response in obese patients undergoing rabies post-exposure prophylaxis with combined equine rabies immunoglobulin and rabies vaccination.	obesity is a risk factor for increased morbidity and mortality associated with many vaccine preventable infectious diseases such as influenza. moreover, higher volume of passive rabies immunoglobulin (rig) due to weight based dosing might suppress vaccine-induced immune responses in obese patients. this study aimed to evaluate the effect of obesity on humoral immune responses to combined equine rig and rabies vaccine treatment among patients with who category iii exposure to a rabies suspected a ...	2018	29191737
the impact of host genetic diversity on virus evolution and emergence.	accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. the vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite e ...	2018	29207441
antigenic site changes in the rabies virus glycoprotein dictates functionality and neutralizing capability against divergent lyssaviruses.	lyssavirus infection has a near 100 % case fatality rate following the onset of clinical disease, and current rabies vaccines confer protection against all reported phylogroup i lyssaviruses. however, there is little or no protection against more divergent lyssaviruses and so investigation into epitopes within the glycoprotein (g) that dictate a neutralizing response against divergent lyssaviruses is warranted. importantly, the facilities required to work with these pathogens, including wild-typ ...	2018	29300155
initial pen and field assessment of baits to use in oral rabies vaccination of formosan ferret-badgers in response to the re-emergence of rabies in taiwan.	taiwan had been considered rabies free since 1961, until a newly established wildlife disease surveillance program identified rabies virus transmission within the formosan ferret-badger (melogale moschata subaurantiaca) in 2013. ferret-badgers occur throughout southern china and southeast asia, but their ecological niche is not well described.	2018	29293591
adjuvant activity of ethanol extract of hippophae rhamnoides leaves with inactivated rabies virus antigen.	hippophae rhamnoides l. (elaeagnaceae), commonly known as seabuckthorn (sbt), is known for its medicinal and nutritional properties.	2018	29235395
development and evaluation of the rt-pcr kit for the rabies virus diagnosis.	to improve the diagnosis, surveillance, and control for the rabies virus, a kit for hybridization-triggered fluorescence detection of rabies virus dna by the rt-pcr technique was developed and evaluated. the analytical sensitivity of the kit was 4*10 ge per ml. high specificity of the kit was shown using representative sampling of viral, bacterial, and human nucleic acids.	2018	29323857
development and evaluation of a rt-qpcr assay for fast and sensitive rabies diagnosis.	rabies virus is endemic to russia, among other countries. it is therefore critical to develop a high-quality and high-precision diagnostic procedure for the control and prevention of infection. the main objective of the research presented here was to develop a reliable rt-qpcr assay for rabies diagnostics. for this purpose, a rabv strains from various biological and geographical origins were used. in addition, rabies-positive and rabies-negative samples, as well as nucleic acids from other virus ...	2018	29108902
efficacy of ontario rabies vaccine baits (onrab) against rabies infection in raccoons.	in the us, rabies lyssavirus (rabv) only circulates in wildlife species and the most significant reservoir from a public and animal health perspective is the raccoon (procyon lotor). management of wildlife rabies relies principally on oral rabies vaccination (orv) strategies using vaccine-laden bait delivery to free-ranging target hosts, in order to reduce the susceptible population to prevent the spread of and eliminate rabv circulation. our objective was to evaluate efficacy of the ontario rab ...	2018	30037482
human rabies associated with domestic cat exposures in south africa, 1983-2018.	no abstract available.	2020	32633988
predicting the presence and titre of rabies virus-neutralizing antibodies from low-volume serum samples in low-containment facilities.	serology is a core component of the surveillance and management of viral zoonoses. virus neutralization tests are a gold standard serological diagnostic, but requirements for large volumes of serum and high biosafety containment can limit widespread use. here, focusing on rabies lyssavirus, a globally important zoonosis, we developed a pseudotype micro-neutralization rapid fluorescent focus inhibition test (pmrffit) that overcomes these limitations. specifically, we adapted an existing micro-neu ...	2020	32931658
defining new pathways to manage the ongoing emergence of bat rabies in latin america.	rabies transmitted by common vampire bats (desmodus rotundus) has been known since the early 1900s but continues to expand geographically and in the range of species and environments affected. in this review, we present current knowledge of the epidemiology and management of rabies in d. rotundus and argue that it can be reasonably considered an emerging public health threat. we identify knowledge gaps related to the landscape determinants of the bat reservoir, reduction in bites on humans and l ...	2020	32911766
updates on rabies virus disease: is evolution toward zombie virus a tangible threat?	human rabies disease is caused by rabies lyssavirus, a virus belonging to rhabdoviridae family. the more frequent means of contagion is through bites of infected mammals (especially dogs, but also bats, skunks, foxes, raccoons and wolves) which, lacerating the skin, directly inoculate virus-laden saliva into the underlying tissues. immediately after inoculation, the rabies virus enters neural axons and migrates along peripheral nerves towards the central nervous system, where it preferentially l ...	2021	33682816