Publications

the impact of host genetic diversity on virus evolution and emergence.	accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. the vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite e ...	2018	29207441
3d reconstruction and standardization of the rat facial nucleus for precise mapping of vibrissal motor networks.	the rodent facial nucleus (fn) comprises motoneurons (mns) that control the facial musculature. in the lateral part of the fn, populations of vibrissal motoneurons (vmns) innervate two groups of muscles that generate movements of the whiskers. vibrissal mns thus represent the terminal point of the neuronal networks that generate rhythmic whisking during exploratory behaviors and that modify whisker movements based on sensory-motor feedback during tactile-based perception. here, we combined retro ...	2018	28958919
infection of neuroblastoma cells by rabies virus is modulated by the virus titer.	rabies is a lethal viral infection that can affect almost all mammals, including humans. to better understand the replication of rabies lyssavirus, we investigated if the viral load in brains naturally infected with rabies influences viral internalization and viral growth kinetics in neuroblastoma cells, and if the viral load affects mortality in mice after intradermal infection. we noted that high initial viral loads in brains (group ii) were unfavourable for increasing viral titers during seri ...	2018	29122670
development of molecular and cellular tools to decipher the type i ifn pathway of the common vampire bat.	though the common vampire bat, desmodus rotundus, is known as the main rabies virus reservoir in latin america, no tools are available to investigate its antiviral innate immune system. to characterize the ifn-i pathway, we established an immortalized cell line from a d. rotundus fetal lung named fludero. then we molecularly characterized some of the toll-like receptors (tlr3, 7, 8 and 9), the three rig-i-like receptor members, as well as ifnα1 and ifnβ. challenging the fludero cell line with po ...	2018	29122634
parainfluenza virus 5-vectored vaccines against human and animal infectious diseases.	parainfluenza virus 5 (piv5), known as canine parainfluenza virus in the veterinary field, is a negative-sense, nonsegmented, single-stranded rna virus belonging to the paramyxoviridae family. parainfluenza virus 5 is an excellent viral vector and has been used as a live vaccine for kennel cough for many years in dogs without any safety concern. it can grow to high titers in many cell types, and its genome is stable even in the presence of foreign gene insertions. so far, piv5 has been used to d ...	2018	29316047
development and evaluation of a rt-qpcr assay for fast and sensitive rabies diagnosis.	rabies virus is endemic to russia, among other countries. it is therefore critical to develop a high-quality and high-precision diagnostic procedure for the control and prevention of infection. the main objective of the research presented here was to develop a reliable rt-qpcr assay for rabies diagnostics. for this purpose, a rabv strains from various biological and geographical origins were used. in addition, rabies-positive and rabies-negative samples, as well as nucleic acids from other virus ...	2018	29108902
efficacy of ontario rabies vaccine baits (onrab) against rabies infection in raccoons.	in the us, rabies lyssavirus (rabv) only circulates in wildlife species and the most significant reservoir from a public and animal health perspective is the raccoon (procyon lotor). management of wildlife rabies relies principally on oral rabies vaccination (orv) strategies using vaccine-laden bait delivery to free-ranging target hosts, in order to reduce the susceptible population to prevent the spread of and eliminate rabv circulation. our objective was to evaluate efficacy of the ontario rab ...	2018	30037482
development and evaluation of the rt-pcr kit for the rabies virus diagnosis.	to improve the diagnosis, surveillance, and control for the rabies virus, a kit for hybridization-triggered fluorescence detection of rabies virus dna by the rt-pcr technique was developed and evaluated. the analytical sensitivity of the kit was 4*10 ge per ml. high specificity of the kit was shown using representative sampling of viral, bacterial, and human nucleic acids.	2018	29323857
human rabies associated with domestic cat exposures in south africa, 1983-2018.	no abstract available.	2020	32633988
predicting the presence and titre of rabies virus-neutralizing antibodies from low-volume serum samples in low-containment facilities.	serology is a core component of the surveillance and management of viral zoonoses. virus neutralization tests are a gold standard serological diagnostic, but requirements for large volumes of serum and high biosafety containment can limit widespread use. here, focusing on rabies lyssavirus, a globally important zoonosis, we developed a pseudotype micro-neutralization rapid fluorescent focus inhibition test (pmrffit) that overcomes these limitations. specifically, we adapted an existing micro-neu ...	2020	32931658
defining new pathways to manage the ongoing emergence of bat rabies in latin america.	rabies transmitted by common vampire bats (desmodus rotundus) has been known since the early 1900s but continues to expand geographically and in the range of species and environments affected. in this review, we present current knowledge of the epidemiology and management of rabies in d. rotundus and argue that it can be reasonably considered an emerging public health threat. we identify knowledge gaps related to the landscape determinants of the bat reservoir, reduction in bites on humans and l ...	2020	32911766
updates on rabies virus disease: is evolution toward zombie virus a tangible threat?	human rabies disease is caused by rabies lyssavirus, a virus belonging to rhabdoviridae family. the more frequent means of contagion is through bites of infected mammals (especially dogs, but also bats, skunks, foxes, raccoons and wolves) which, lacerating the skin, directly inoculate virus-laden saliva into the underlying tissues. immediately after inoculation, the rabies virus enters neural axons and migrates along peripheral nerves towards the central nervous system, where it preferentially l ...	2021	33682816