Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| surveillance of the activity of solithromycin (cem-101) against bacteria from respiratory tract infections. | the activity of solithromycin, a fourth-generation macrolide and novel fluoroketolide, was evaluated by determining its minimum inhibitory concentration (mic) (via clinical and laboratory standards institute broth microdilution) against 2797 contemporary clinical respiratory tract isolates collected from north america, europe, asia-pacific and other regions of the world in 2012-13. solithromycin was very active against streptococcus pneumoniae and streptococcus pyogenes, with mic90 of 0.25 and 0 ... | 2017 | 28483717 |
| effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among greenlandic children. | in 2010, greenland introduced the 13-valent pneumococcal conjugate vaccine (prevnar 13®- pcv-13) in the childhood immunisation program. the authors aimed to evaluate the impact of pcv-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. | 2017 | 28467237 |
| effects of n-acetyl-l-cysteine on the membrane vesicle release and growth of respiratory pathogens. | bacterial infections contribute to the disease progression of chronic obstructive pulmonary disease by stimulating mucus production in the airways. this increased mucus production and other symptoms are often alleviated when patients are treated with mucolytics such as n-acetyl-l-cysteine (nac). moreover, nac has been suggested to inhibit bacterial growth. bacteria can release membrane vesicles (mvs) in response to stress, and recent studies report a role for these proinflammatory mvs in the pat ... | 2017 | 28444395 |
| a prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in copd. | the aetiology of acute exacerbations of copd (aecopd) is incompletely understood. understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. | 2017 | 28432209 |
| etiological analysis and epidemiological comparison among adult cap and nhcap patients in okinawa, japan. | etiological epidemiology and diagnosis are important issues for cap and nhcap. despite the availability of effective therapies, significant morbidity and mortality ensues. | 2017 | 28431934 |
| nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. | we sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (uri) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients. | 2017 | 28412081 |
| nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | we reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. we also showed defects in phagocytosis of nontypeable haemophilus influenzae (nthi), a common colonizer of the lower airway in these diseases. these defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. the aim of t ... | 2017 | 28258107 |
| preferential aerosolization of bacteria in bioaerosols generated in vitro. | little is known about how bacteria are aerosolized in terms of whether some bacteria will be found in the air more readily than others that are present in the source. this report describes in vitro experiments to compare aerosolization rates (also known as preferential aerosolization) of gram-positive and gram-negative bacteria as well as rod- and coccus-shaped bacteria, using two nebulization conditions. | 2017 | 28632907 |
| a moraxella catarrhalis vaccine to protect against otitis media and exacerbations of copd: an update on current progress and challenges. | moraxella catarrhalis is a major cause of morbidity and mortality worldwide, especially causing otitis media in young children and exacerbations of chronic obstructive pulmonary disease in adults. this pathogen employs several virulence mechanisms to colonize and survive in its host, including adherence and invasion of host cells, formation of polymicrobial biofilms with other bacterial pathogens and production of beta-lactamase. given the global impact of otitis media and copd, an effective vac ... | 2017 | 28853985 |
| stringently defined otitis prone children demonstrate deficient naturally induced mucosal antibody response to moraxella catarrhalis proteins. | moraxella catarrhalis (mcat) is a prominent mucosal pathogen causing acute otitis media (aom). we studied mcat nasopharyngeal (np) colonization, aom frequency and mucosal antibody responses to four vaccine candidate mcat proteins: outer membrane protein (omp) cd, oligopeptide permease (opp) a, hemagglutinin (hag), and pilin a clade 2 (pila2) from stringently defined otitis prone (sop) children, who experience the greatest burden of disease, compared to non-otitis prone (nop) children. sop childr ... | 2017 | 28848555 |
| molecular characterization of fluoroquinolone-resistant moraxella catarrhalis variants generated in vitro by stepwise selection. | moraxella catarrhalis causes respiratory infections. in this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets, gyr and par, were sequenced. six novel mutations in gyra (d84y, t594dup, and a722dup), gyrb (e479k and d439n), and pare (q395r) involved in m. catarrhalis resistance to fluoroquinolone ... | 2017 | 28760904 |
| treatment challenges of group a beta-hemolytic streptococcal pharyngo-tonsillitis. | introduction despite its in vitro efficacy, penicillin often fails to eradicate group a β-hemolytic streptococci (gabhs) from patients with acute and relapsing pharyngo-tonsillitis (pt). objective this review of the literature details the causes of penicillin failure to eradicate gabhs pt and the therapeutic modalities to reduce and overcome antimicrobial failure. data synthesis the causes of penicillin failure in eradicating gabhs pt include the presence of β lactamase producing bacteria (bl ... | 2017 | 28680500 |
| a cation-binding surface protein as a vaccine antigen to prevent moraxella catarrhalis otitis media and infections in chronic obstructive pulmonary disease. | moraxella catarrhalis is an exclusively human respiratory tract pathogen that is a common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. a vaccine to prevent these infections would have a major impact in reducing the substantial global morbidity and mortality in these populations. through a genome mining approach, we identified afea, an ∼32 kda substrate binding protein of an abc transport system as an excellent candidate ... | 2017 | 28659326 |
| isogenic mutations in the moraxella catarrhalis cyddc system display pleiotropic phenotypes and reveal the role of a palindrome sequence in its transcriptional regulation. | moraxella catarrhalis is becoming an important human respiratory tract pathogen affecting significant proportions from the population. however, still little is known about its physiology and molecular regulation. to this end, the cyddc, which is a heterodimeric atp binding cassette transporter that has been shown to contribute to the maintenance of the redox homeostasis across the periplasm in other gram-negative bacteria, is studied here. amino acids multiple sequence alignments indicated that ... | 2017 | 28647125 |
| infection after total knee arthroplasty by m. catarrhalis associated with rheumatoid arthritis and dmards therapy. | moraxella catarrhalis is not commonly associated with prosthetic joint infection (pji). we present the first case of a patient with rheumatoid arthritis on certolizumab, an antitumor necrosis factor therapy, who developed pji following a total knee replacement. | 2017 | 28583061 |
| complete genome sequence of moraxella catarrhalis strain ccri-195me, isolated from the middle ear. | moraxella catarrhalis is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. here, we report the complete genome sequence of m. catarrhalis strain ccri-195me, which contains the phase-variable epigenetic regulator modm3. | 2017 | 28546484 |
| colonisation of antibiotic resistant bacteria in a cohort of hiv infected children in ghana. | antibiotic use not only selects for resistance in pathogenic bacteria, but also in commensal flora of exposed individuals. little is known epidemiologically about antibiotic resistance in relation to people with hiv infection in sub-saharan africa. this study investigated the carriage of antibiotic resistant bacteria among hiv infected children at a tertiary hospital in ghana. one hundred and eighteen hiv positive children were recruited at the korle-bu teaching hospital in ghana and nasopharyng ... | 2017 | 28451037 |
| deciphering upper respiratory tract microbiota complexity in healthy calves and calves that develop respiratory disease using shotgun metagenomics. | bovine respiratory disease (brd) is a multifactorial disorder responsible for severe economic losses in dairy and feedlot herds. advances in next-generation sequencing mean that microbial communities in clinical samples, including non-culturable bacteria, can be characterized. our aim was to evaluate the microbiota of the upper respiratory tract of healthy calves and calves with brd using whole-genome sequencing (shotgun metagenomics). we performed deep nasopharyngeal swabs on 16 holstein heifer ... | 2017 | 27988122 |
| moraxella catarrhalis meningitis during certolizumab pegol treatment. | 2017 | 28336117 | |
| moraxella catarrhalis macrolide-resistant isolates are highly concentrated in two mlst clonal complexes -ccn10 and cc363. | to gain some insights into the molecular evolution of moraxella catarrhalis macrolide resistance, pcr and sequencing analysis of the 23s rrna gene, copb typing and multilocus sequence typing (mlst) were performed on 181 m. catarrhalis isolates. the isolates were obtained from children (n = 47) and adults (n = 134) presenting with respiratory disease in the years 2010-2014. macrolide resistance was highly age-related, and nucleotide position alterations at a2330t could be detected in all macrolid ... | 2017 | 28239374 |
| oral microbiota in infants fed a formula supplemented with bovine milk fat globule membranes - a randomized controlled trial. | in a recent study, supplementation of infant formula with milk fat globule membranes (mfgm) decreased the incidence of otitis media in infants <6 months of age. | 2017 | 28099499 |
| acyl chain preference and inhibitor identification of moraxella catarrhalis lpxa: insight through crystal structure and computational studies. | lipopolysaccharide (lps) is an important surface component and a potential virulence factor in the pathogenesis of gram-negative bacteria. udp-n-acetylglucosamine acyltransferase (lpxa) enzyme catalyzes the first reaction of lps biosynthesis, reversible transfer of r-3-hydroxy-acyl moiety from donor r-3-hydroxy-acyl-acyl carrier protein to the 3' hydroxyl position of udp-n-acetyl-glucosamine. lpxa enzyme's essentiality in bacterial survival and absence of any homologous protein in humans makes i ... | 2017 | 28057571 |
| seasonal patterns and association of meteorological factors with infection caused by streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis in childhood community-acquired pneumonia in a tropical region. | 2017 | 27464260 | |
| prelp enhances host innate immunity against the respiratory tract pathogen moraxella catarrhalis. | respiratory tract infections are one of the leading causes of mortality worldwide urging better understanding of interactions between pathogens causing these infections and the host. here we report that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (prelp) is a novel antibacterial component of innate immunity. we detected the presence of prelp in human bronchoalveolar lavage fluid and showed that prelp can be found in alveolar fluid, resident macrophages ... | 2017 | 28148731 |
| prospective evaluation of the aetiology of acute otitis media with spontaneous tympanic membrane perforation. | to evaluate the aetiological role of the main bacterial pathogens associated with acute otitis media (aom) in children with aom and spontaneous tympanic membrane perforation (stmp). | 2017 | 28110050 |
| aqueous humor antimicrobial activity: in vitro analysis after topical 0.5% chloramphenicol application. | to assess aqueous humor antimicrobial activity in vitro after topical 0.5% chloramphenicol application. | 2017 | 28085501 |
| nasopharyngeal carriage of respiratory pathogens in warao amerindians: significant relationship with stunting. | to assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated warao amerindians in venezuela. | 2017 | 28072501 |
| recent epidemiology of streptococcus pneumoniae in nasopharynxes of korean children with acute otitis media. | this prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of streptococcus pneumoniae identified in korean children with acute otitis media (aom) after the introduction of a 7-valent pneumococcal conjugate vaccine (pcv7). | 2017 | 28024738 |
| panel 6: vaccines. | objective to review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (om) and (2) development of vaccine antigens for om bacterial and viral pathogens. data sources pubmed database of the national library of science. review methods we performed literature searches in pubmed for om pathogens and candidate vaccine antigens, and we restricted the searches to articles in english that were published between july 2011 and june 2015. panel members review ... | 2017 | 28372533 |
| the role of acute and chronic respiratory colonization and infections in the pathogenesis of copd. | copd is a major global concern, increasingly so in the context of ageing populations. the role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. while copd pathogens such as haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae are strongly associated with acute exacerbations of copd (aecopd), the clinical relevance of these pathogens in stable copd patients remains unclear. immune respo ... | 2017 | 28342288 |
| il-33/st2 immune responses to respiratory bacteria in pediatric asthma. | here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the eu-wide study predicta. in this cohort of pre-school asthmatic children, nasopharyngeal colonization with gram-negative bacteria such as haemophilus influenzae and moraxella catarrhalis was found to be associated with the highest interferon beta (ifnβ) and il-33 levels in the nasal pharyngeal fluids (npf). il33r-st2 was found induc ... | 2017 | 28262704 |
| design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. | erythromycin was long viewed as a bacteriostatic agent. the erythromycin derivatives, 9-oxime ketolides have a species-specific bactericidal profile. among them, the 3'-allyl version of the 9-oxime ketolide 1 (ar=3-quinolyl; 17a) is bactericidal against streptococcus pneumoniae and streptococcus pyogenes. in contrast, the 2-fluoro analogs of 1, 13a (ar=6-quinolyl), 13b (ar=3-quinolyl) and 24a (ar=4-isoquinolyl), show bactericidal activities against s. pneumoniae, staphylococcus aureus and moraxe ... | 2017 | 28256375 |
| simultaneous detection of nine key bacterial respiratory pathogens using luminex xtag(®) technology. | early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (lrtis). in this study, we developed an assay combining multiplex pcr and luminex technology (mplt) for the detection of nine important respiratory bacterial pathogens, which frequently cause lrtis. these were streptococcus pneumoniae, moraxella catarrhalis, staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae, mycoplasma pneumoniae, legionella spp., pseudomonas aeruginosa, and klebsie ... | 2017 | 28241513 |
| comparison of pathogen eradication rate and safety of anti-bacterial agents for bronchitis: a network meta-analysis. | a large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. we are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis. | 2017 | 28230273 |
| do we need a vaccine against moraxella catarrhalis in chronic lung disease? what are the options and opportunities? | moraxella catarrhalis is the second most common cause of exacerbations in adults with copd, resulting in enormous morbidity and mortality in this clinical setting. vaccine development for m. catarrhalis has lagged behind the other two important causes of exacerbations in copd, nontypeable haemophilus influenzae and streptococcus pneumoniae. while no licensed vaccine is currently available for m. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and ... | 2017 | 28185742 |
| longitudinal assessment of sputum microbiome by sequencing of the 16s rrna gene in non-cystic fibrosis bronchiectasis patients. | bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. however, the evidence base for antibiotic therapy is limited. dna based methods offer better identification and quantification of microbial constituents of sputum than standard clinical culture and may help inform patient management strategies. our study objective was to determine the longitudinal variability of the non-cystic fibrosis (cf) bronchiectasis microbiome in sputum with respect to clinical ... | 2017 | 28170403 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| antibacterial screening of rumex species native to the carpathian basin and bioactivity-guided isolation of compounds from rumex aquaticus. | plants belonging to the genus rumex (family polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). the present study focused on the antibacterial screening of rumex species native to the carpathian basin, and isolation of compounds from one of the most efficient species, rumex aquaticus. the antibacterial effects of n-hexane, chloroform and aqueous ... | 2017 | 28300698 |
| surveillance of omadacycline activity tested against clinical isolates from a global (north america, europe, latin america and asia-western pacific) collection (2010-2011). | omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. in this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in asia-pacific (11,397 isolates), europe (23,490 isolates), latin america (8,038 isolates) and no ... | 2017 | 28223386 |
| next-generation sequencing combined with specific pcr assays to determine the bacterial 16s rrna gene profiles of middle ear fluid collected from children with acute otitis media. | the aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). the bacteriome profiles of middle ear fluid samples were determined by a nested-pcr amplification of the 16s rrna gene (v4 region), followed by mass sequencing. the prof ... | 2017 | 28357413 |
| microbiology of otitis media in indigenous australian children: review. | to review research addressing the polymicrobial aetiology of otitis media in indigenous australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions. | 2017 | 28088924 |
| the 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial. | pneumococcal pneumonia is the most frequent form of pneumonia. we herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (ppsv23) in the prevention of pneumonia overall in rheumatoid arthritis (ra) patients at risk for infections. we hypothesized that ppsv23 vaccination is superior in preventing pneumococcal pneumonia compared with placebo in ra patients. | 2017 | 28122642 |
| prospective surveillance of healthcare associated infections in a cambodian pediatric hospital. | healthcare associated infections (hai) are the most common preventable adverse events following admission to healthcare facilities. data from low-income countries are scarce. we sought to prospectively define hai incidence at angkor hospital for children (ahc), a cambodian pediatric referral hospital. | 2017 | 28138385 |
| evaluation of three sample preparation methods for the direct identification of bacteria in positive blood cultures by maldi-tof. | patient mortality is significantly reduced by rapid identification of bacteria from sterile sites. maldi-tof can identify bacteria directly from positive blood cultures and multiple sample preparation methods are available. we evaluated three sample preparation methods and two maldi-tof score cut-off values. positive blood culture bottles with organisms present in gram stains were prospectively analysed by maldi-tof. three lysis reagents (saponin, sds, and sepsityper lysis bufer) were applied to ... | 2017 | 28100271 |
| recurrent pneumonia among japanese adults: disease burden and risk factors. | in japan and other societies with rapidly aging populations, recurrent pneumonia (rp) is a major clinical problem yet only limited information exists regarding the burden of this disease. | 2017 | 28077107 |
| secondary metabolites from bacillus amyloliquefaciens isolated from soil can kill burkholderia pseudomallei. | bacillus species are gram-positive bacteria found in abundance in nature and their secondary metabolites were found to possess various potential activities, notably antimicrobial. in this study, bacillus amyloliquefaciens n2-4 and n3-8 were isolated from soil and their metabolites could kill burkholderia pseudomallei, a gram-negative pathogenic bacterium also found in soil in its endemic areas. moreover, the metabolites were able to kill drug resistant isolates of b. pseudomallei and also inhibi ... | 2017 | 28050857 |
| can contaminated water be rendered safe for nasal saline irrigations? | to compare sterile water to three methods of sterilization (carbon filtration, boiling, and ultraviolet [uv] light) for preparation of nasal saline irrigants free of bacterial and amebic contaminants. | 2017 | 28224696 |