Publications

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re: age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. 201020360534
[human papillomavirus infections in urology]. 201020223127
abnormal anal cytology in hiv-infected women.the purpose of this study was to assess the prevalence of and risk factors for abnormal anal cytology and human papillomavirus (hpv) infections in women who are human immunodeficiency virus (hiv) positive.201020223443
hpv testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort study.to determine whether offering self sampling of cervicovaginal material for high risk human papillomavirus (hpv) testing is an effective screening method for women who do not attend regular cervical screening programmes.201020223872
empirically evaluating decision-analytic models.model-based cost-effectiveness analyses support decision-making. to augment model credibility, evaluation via comparison to independent, empirical studies is recommended.201020230547
model-based estimation of viral transmissibility and infection-induced resistance from the age-dependent prevalence of infection for 14 high-risk types of human papillomavirus.viral transmissibility and natural resistance to infection are key determinants in assessing the population impact of human papillomavirus (hpv) vaccination, yet information on these parameters is scarce. using data from 2 large-scale surveys on sexual behavior in the netherlands (carried out in 2005-2006), the authors employed a bayesian framework to fit a transmission model to the cross-sectional age-dependent prevalence of hpv dna in cervical smears (data collected in 1992-2002), assuming tha ...201020231211
research on cancer prevention, detection and management in low- and medium-income countries.the burden of cancer in low- and medium-income countries (lmic) is expected to increase in the next decades. the application of current knowledge and results of research in key areas would contribute to limit the impact of this phenomenon. opportunities for research on cancer prevention in lmic include investigating specific circumstances of exposure to known carcinogens and to agents which are not prevalent in other regions, as well as interactions among carcinogens and between genetic and envi ...201020231304
human papillomavirus dna and oncogene alterations in colorectal tumors.the aim of the present study is to determine the presence and molecular integrity of high-risk hpv types in colorectal adenocarcinomas and to assess whether viral dna is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer. seventy-five colorectal adenocarcinomas were screened for hpv infection using nested-pcr (my09/11-gp5+/6+). hpv typing was performed by type-specific pcr for hpv 16 and hpv 18 dna. unidentified samples were s ...201020232185
bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer.oropharyngeal squamous cell carcinoma (opscc) associated with human papilloma virus (hpv) is rapidly growing in incidence. despite better prognosis than opscc associated with traditional risk factors, treatment failure still occurs in a significant proportion of patients. we had identified the antiapoptotic protein bcl2 as a marker for poor outcome in advanced opscc treated with concurrent chemoradiation. to determine whether bcl2 and hpv together might further characterize treatment response, w ...201020233885
phase ii trial of imiquimod and hpv therapeutic vaccination in patients with vulval intraepithelial neoplasia.vulval intraepithelial neoplasia (vin) is a premalignant condition, which is frequently associated with type hpv16 infection, and multifocal disease has high rates of surgical treatment failure.201020234368
high-resolution genomic profiling of human papillomavirus-associated vulval neoplasia.the incidence of human papillomavirus-associated vulval neoplasia is increasing worldwide; yet the associated genetic changes remain poorly understood.201020234371
human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma.basaloid squamous cell carcinoma of the upper aerodigestive tract is a rare, morphologically distinct variant of squamous cell carcinoma that is thought to be clinically aggressive. the histologic features are distinct from, but often confused with, those of human papillomavirus-related oropharyngeal nonkeratinizing squamous cell carcinoma. the role of human papillomavirus as an etiologic agent in true basaloid squamous cell carcinoma is controversial. the purpose of this study was to determine ...201020236687
multiplexed serologic assay for nine anogenital human papillomavirus types.a multiplexed human papillomavirus (hpv) immunoassay has been developed for the detection of human igg antibodies to hpv type 6, 11, 16, 18, 31, 33, 45, 52, and 58 virus-like particle (vlp) types in serum following natural infection or immunization with vlp-based vaccines. the vlp antigens were covalently conjugated to carboxyl luminex microspheres (ms) using a carbodiimide chemistry. antibody (ab) titers were determined in a direct binding format, in which an igg1- to -4-specific, phycoerythrin ...201020237197
a cancer derived mutation in the retinoblastoma gene with a distinct defect for lxcxe dependent interactions.the interaction between viral oncoproteins such as simian virus 40 tag, adenovirus e1a, and human papilloma virus e7, and the retinoblastoma protein (prb) occurs through a well characterized peptide sequence, lxcxe, on the viral protein and a well conserved groove in the pocket domain of prb. cellular proteins, such as histone deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress transcription at cell cycle regulated genes. for these reasons this region of ...201020298605
immunotherapy for cervical cancer: research status and clinical potential.the high-risk types of human papillomavirus (hpv) have been found to be associated with most cervical cancers and play an essential role in the pathogenesis of the disease. despite recent advances in preventive hpv vaccine development, such preventive vaccines are unlikely to reduce the prevalence of hpv infections within the next few years, due to their cost and limited availability in developing countries. furthermore, preventive hpv vaccines may not be capable of treating established hpv infe ...201020199126
prophylactic human papillomavirus vaccines: will they do their job?the prophylactic hpv l1 virus like particle vaccines are highly efficacious preventing >98% of hpv 16/18 caused high grade cervical intra-epithelial neoplasia (cin2/3) according to protocol group in phase iii randomized clinical trials over approximately 4 years. data from the trials together with postvaccine surveillance indicates that they have a good safety profile. as the current hpv vaccines include only two of the 15 oncogenic hpvs, they will not eliminate cervical cancer or the other hpv ...201020201919
the impact of intolerance of uncertainty on anxiety after receiving an informational intervention about hpv: a randomised controlled study.this study examined the impact of intolerance of uncertainty (iu) and an informational intervention about human papillomavirus (hpv) infection on perceived uncertainty about one's hpv testing status (referred to as 'hpv uncertainty') and anxiety. iu, hpv uncertainty and other pre-intervention measures were assessed through mailed questionnaires. participants were then randomly assigned to receive either a long (n = 125) or short (n = 124) hpv-specific information pamphlet or a long (n = 131) or ...201020204959
the quality of life of patients with genital warts: a qualitative study.genital warts, which are caused by infection with human papillomavirus (hpv), are one of the most common sexually transmitted diseases in europe. although genital warts are commonly perceived as a non-serious condition, treatment is often long, of varying effectiveness and the recurrence rate is high. very few studies have been performed on the personal consequences of genital warts. the aim of this qualitative study, set in denmark, was to examine the ways in which genital warts may affect pati ...201020205944
parental acceptance of a mandatory human papillomavirus (hpv) vaccination program.the objective of this study was to determine factors that influence parent's acceptance of a mandatory school-based human papillomavirus (hpv) vaccination program.201020207933
a c-terminal hydrophobic, solvent-protected core and a flexible n-terminus are potentially required for human papillomavirus 18 e7 protein functionality.the oncogenic potential of the high-risk human papillomavirus (hpv) relies on the expression of genes specifying the e7 and e6 proteins. to investigate further the variation in oligomeric structure that has been reported for different e7 proteins, an hpv-18 e7 cloned from a hispanic woman with cervical intraepithelial neoplasia was purified to homogeneity most probably as a stable monomeric protein in aqueous solution. we determined that one zinc ion is present per hpv-18 e7 monomer by amino aci ...201020211680
the location of endogenous wild-type p53 protein in 293t and hek293 cells expressing low-risk hpv-6e6 fusion protein with gfp.the mechanism underlining human papillomaviruses (hpvs) causing cancer has been studied extensively, and it was concluded that the high-risk hpvs' e6 targeted and degraded tumor suppressor protein p53, leading to infected cells malignant transformation. in contrast, the low-risk hpvs only cause proliferative but non-invasive lesions of infected epithelia. therefore, we hypothesized that low-risk hpvs' e6 might interact with p53 in a different pattern. we used a mammalian green fluorescent protei ...201020213049
is recurrent pseudoepitheliomatous keratotic balanitis related to human papillomavirus infection? 201020169317
molecular targeted therapies in all histologies of head and neck cancers: an update.this article reviewed the recent developments in molecular targeted therapy in head and neck cancers. a brief summary of other pathways of interest is also enclosed.201020173639
european guidelines for quality assurance in cervical cancer screening. second edition--summary document.european guidelines for quality assurance in cervical cancer screening have been initiated in the europe against cancer programme. the first edition established the principles of organised population-based screening and stimulated numerous pilot projects. the second multidisciplinary edition was published in 2008 and comprises approximately 250 pages divided into seven chapters prepared by 48 authors and contributors. considerable attention has been devoted to organised, population-based program ...201020176693
comment re: detection of cervical precancer by hpv genotype. 201020179199
human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer.abstract:201020181227
human papillomavirus genotyping using archival vulval dysplastic or neoplastic biopsy tissues: comparison between the inno-lipa and linear array assays.the roche linear array (la) and innogenetics inno-lipa human papillomavirus (hpv) genotyping assays were compared for paraffin-embedded vulval tissues. the la detected amplifiable dna in 28 (57%) out of 49 biopsy specimens, 20 (40%) being hpv genotyped, compared to 49 (100%) and 41 (83%), respectively, detected by the inno-lipa. the inno-lipa provides greater sensitivity for hpv genotyping in archival tissue.201020181920
dna vaccines for cervical cancer.human papillomavirus (hpv), particularly type 16, has been associated with more than 99% of cervical cancers. there are two hpv oncogenic proteins, e6 and e7, which play a major role in the induction and maintenance of cellular transformation. thus, immunotherapy targeting these proteins may be employed for the control of hpv-associated cervical lesions. although the commercially available preventive hpv vaccines are highly efficient in preventing new hpv infection, they do not have therapeutic ...201020182584
anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from germany.anal intraepithelial neoplasia (ain), a human papillomavirus (hpv)-associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (hiv)-positive men who have sex with men (msm). there is a paucity of data published on the progression of high-grade ain to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma.201020184584
anomalous dna binding by e2 regulatory protein driven by spacer sequence tata.we have investigated the anomalously weak binding of human papillomavirus (hpv) regulatory protein e2 to a dna target containing the spacer sequence tata. experiments in magnesium (mg(2+)) and calcium (ca(2+)) ion buffers revealed a marked reduction in cutting by dnase i at the cpg sequence in the protein-binding site 3' to the tata spacer sequence, studies of the cation dependence of dna-e2 affinities showed that upon e2 binding the tata sequence releases approximately twice as many mg(2+) ions ...201020185566
comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience.human papillomavirus (hpv) is a causative agent in a subset of head and neck squamous cell carcinomas (hnsccs). these hpv-related cancers have a clinicopathologic profile that diverges from hpv-negative hnsccs. accordingly, hpv testing may soon become integrated into standard pathologic assessment of hnsccs.201020186832
acceptability of human papillomavirus vaccine for males: a review of the literature.the quadrivalent human papillomavirus virus vaccine was recently licensed for use in males in the united states. this study reviews available published literature on acceptability among parents, health care providers, and young males. among 23 published articles, half were conducted in the united states. the majority (87%) used quantitative survey methodology, and 13% used more explorative qualitative techniques. convenience samples were used in most cases (74%) and 26% relied on nationally repr ...201020113917
immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women.many countries recommend human papillomavirus (hpv) vaccination in female adolescents at an age when other vaccines are routinely administered. this open, randomized, multicenter study (108464/nct00426361) evaluated coadministration of hpv-16/18 as04-adjuvanted vaccine with diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (dtpa-ipv).201020113920
enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 l1 protein with adjuvants.needle-free nonparenteral vaccines offer a number of practical advantages, especially in developing countries. to address the effects of vaccine administration route, we tested mucosal and systemic immune responses against human papillomavirus 16 l1(hpv16l1) protein using intranasal, intravaginal, transdermal, sublingual (sl) and intramuscular routes. the sl route provided the most effective mucosal secretory iga (siga) and serum igg responses. after a 150 microg antigen dose via the sl route, s ...201020116467
predictors of parents' willingness to vaccinate for human papillomavirus and physicians' intentions to recommend the vaccine.the present study examined potential predictors of parents' willingness to vaccinate their children for human papillomavirus (hpv) and physicians' intentions to encourage parents to vaccinate their children, now that the u.s. food and drug administration (fda) has approved a highly effective vaccine.201020123174
epigenetic repression of e-cadherin by human papillomavirus 16 e7 protein.a common feature shared between several human cancer-associated viruses, such as epstein-barr virus, hepatitis b virus and hepatitis c virus, and human papillomavirus (hpv) is the ability to reduce the expression of cellular e-cadherin. since e-cadherin is used by langerhans cells to move through the stratified epithelium, its reduction may affect the efficiency by which the immune system responds to hpv infection and the length of persistent hpv infections. we observed that the e7 protein of th ...201020123756
[exploring the issue of cervical cancer prevention and control in women living with hiv/aids].shared risk factors mean that women engaging in unprotected sex are at risk of contracting both the human immunodeficiency virus (hiv) and the human papillomavirus (hpv). as hiv suppresses bodily immune systems, an hiv-positive woman with hpv will likely see a faster progression of cancer cells around the cervix. therefore, it is important to prevent and control cervical cancer in hiv-positive women. findings from the literature on this topic include: 1) hiv-positive women face a relatively grea ...201020127625
interferon regulatory factor (irf)-2 activates the hpv-16 e6-e7 promoter in keratinocytes.interferon regulatory factors (irfs) are critical mediators of gene expression, cell growth and immune responses. we previously demonstrated that interferon (ifn) induction of early viral transcription and replication in several mucosal hpvs requires irf-1 binding to a conserved interferon response element (ire). here we show that the irf-2 protein serves as a baseline transactivator of the hpv-16 major early promoter, p97. cotransfections in irf knockout cells confirmed that basal hpv-16 promot ...201020129639
prevalence and type distribution of human papillomavirus in women with cervical lesions in liaoning province, china.instruction: type-specific persistence of human papillomavirus (hpv) infection can cause invasive cervical cancer. the distribution and prevalence of hpv genotypes depend on the geographic region and on demographic factors.201020130516
human papillomavirus dna in plasma of patients with hpv16 dna-positive uterine cervical cancer.the squamous cell carcinoma antigen is considered the most accurate serologic tumor marker for uterine cervical carcinoma. however, serum squamous cell carcinoma antigen levels were found to correlate significantly with clinical severity of atopic dermatitis and chronic renal failure. the present study was conducted in patients with human papillomavirus 16 dna-positive uterine cervical cancer to determine the plasma level of human papillomavirus 16 dna and the diagnostic values of plasma human p ...201020133337
diagnostic efficacy of real-time optical coherence tomography in the management of preinvasive and invasive neoplasia of the uterine cervix.determine the sensitivity and specificity of optical coherence tomography (oct) as an adjunct to colposcopy in the detection of cervical intraepithelial neoplasia (cin) grade 2 or higher in a real-time clinical evaluation.201020134271
pem renders tumor cells resistant to apoptotic cell death induced by a cd8+ t cell-mediated immune response or anticancer drug treatment.pem, a member of homeobox genes, is an oncofetal gene which is preferentially expressed in reproductive tissues and in multiple tumor cell lines. however, the function of pem in tumor cell lines has not been elucidated. herein we report that the ectopic expression of pem in tc-1, a human papillomavirus type 16 (hpv-16) e7-expressing surrogate cervical tumor cell line, demonstrated a significant increase in extracellular signal-regulated kinase (erk) activity and multiple resistance to various ap ...201020137854
epidemiology and pathology of hpv disease in males.it is currently recognized that besides the significant impact of human papillomavirus (hpv) infection in females, hpv causes substantial disease in men as well. genital warts are a common manifestation of male infection with hpv. genital warts are highly infectious and approximately 65% of people who have sex with an infected partner will develop warts themselves. more than 90% of genital warts are caused by non-oncogenic hpv types 6 and 11. in addition, recurrent respiratory papillomatosis is ...201020138345
presence of human papillomavirus (hpv) in vulvar squamous cell carcinoma (vscc) and sentinel node.to investigate the presence of hpv in vscc and sentinel nodes (sn) in patients in sweden and the possible influence of hpv on prognosis.201020138657
invasive and in situ cervical cancer reported to the vaccine adverse event reporting system (vaers).the quadrivalent human papillomavirus (hpv) vaccine was recommended in 2006 for routine vaccination of 11 or 12-year-old girls, with catchup through age 26 years, for the prevention of genital hpv-related diseases. the vaccine adverse event reporting system (vaers) is a national spontaneous surveillance system of adverse events following vaccination in the united states. the objective of this study was to identify and review vaers reports of invasive and in situ cervical cancer in women immunize ...201020141382
human papillomavirus types 16, 18, and 31 serostatus and prostate cancer risk in the prostate cancer prevention trial.since human papillomavirus (hpv) infection was first identified as a risk factor for cervical cancer, several seroepidemiologic and tissue-based studies have investigated hpv in relation to prostate cancer, another common genitourinary malignancy, with mixed results. to further inform this potential association, we conducted a large, prospective investigation of hpv types 16, 18, and 31 in relation to risk of prostate cancer in the prostate cancer prevention trial. cases were a sample of men dia ...201020142255
combining t-cell vaccination and application of agonistic anti-gitr mab (dta-1) induces complete eradication of hpv oncogene expressing tumors in mice.we generated an adenovirus-based t-cell vaccine (ad-p14) that reliably elicits t-cell responses to human papillomavirus (hpv) oncogenes of the 2 most common high-risk hpv serotypes. the artificial gene used to create the vaccine comprising 415 aa (1248 bp) was cloned by fusing 14 polymerase chain reaction fragments of hpv16 and hpv18 e6 and e7 oncogenes devoid of sequences with transforming potential. although ensuring maximal biologic safety, the construct includes approximately 70% of the rele ...201020145549
cloning and characterization of cell strains derived from human corneal stroma and sclera.to establish human corneal stroma- and sclera-derived cells as models for studying diseases of the anterior segment of the eye.201020151280
providing high quality information about human papillomavirus for women after treatment for high-grade cervical dysplasia.the present study aimed to inform the production of a resource for women who have had a high-grade cervical abnormality and are scheduled to undergo testing for human papillomavirus (hpv) at their 12-month follow-up.201020152096
vaccinating adolescent girls against human papillomavirus-who decides? 201020153358
[women's knowledge about cervical cancer].the human papillomavirus-infection is one of the most frequent sexually transmitted disease; it is detectable in nearly all cases of cervical cancer. nowadays, the incidence of cervical cancer is unacceptable high.201020154001
longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection.the natural history of human papillomavirus (hpv) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. in a 7-year population-based cohort study in guanacaste, costa rica, we examined whether women's age and the duration of carcinogenic hpv infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (cin 2) or worse disease.201020157096
[anal cancer and human papillomaviruses: a perspective based on the cervical cancer model].anal cancer is a rare pathology in the general population but the incidence of this cancer has been on the rise for certain high-risk groups, such as homosexual men and immunodepressed subjects. the incidence of anal cancer is 10 times higher in the hiv-positive population than in the female population in general. moderate to severe dysplasias (ain2-3) are types of precancerous lesions that usually precede the appearance of the cancer. hpv16 infection is the most common (3/4 of the cases) follow ...201020362481
[expression of survivin, bcl-2 in cervical carcinoma and its association with hpv16/18 infection].to investigate the expression and the correlation of surviving, bcl-2 and hpv16/18 in cervical carcinoma.201020368071
dual action microbicides: reappraisal of their roles in contraceptive research.of the variety of contraceptive options available for women, very few provide dual protection against sexually transmitted diseases. due to increased incidence of human immunodeficiency virus type 1 (hiv-1), genital herpes, hepatitis b and human papilloma virus, development of novel contraceptive strategies that incorporate antiviral activity has become the top priority in contraceptive research. topical microbicides are now considered to be the last ray of hope, as they would ideally provide pr ...201020158995
quinacrine sterilization and gynecologic cancers: a case-control study in northern vietnam.over 100,000 women worldwide have been sterilized by insertion of quinacrine into the uterus to induce tubal scarring. concern has been expressed about possible carcinogenicity, and specifically the risk of uterine cancer.201020160560
protein p 16ink4a expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix.the association of human papilloma virus (hpv) infection and cervical intraepithelial neoplasia (cin) is well recognized. interaction of hpv oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 ink4a , a cdk inhibitor, which is a biomarker for hpv infection. we investigated p16 expression in cin and invasive squamous cell carcinoma (scc) which has not been reported in the indian population previously.201020090213
relationship of atypical glandular cell cytology, age, and human papillomavirus detection to cervical and endometrial cancer risks.to quantify the age-specific and reproductive organ-specific cancer risk after an atypical glandular cell (agc) cytologic interpretation in large clinic-based sample in which routine high-risk human papillomavirus (hpv) testing is conducted.201020093895
surgical treatment of epidermodysplasia verruciformis.epidermodysplasia verruciformis (ev) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients.201020100263
association of hiv infection with distribution and viral load of hpv types in kenya: a survey with 820 female sex workers.human papillomavirus (hpv) and hiv are each responsible for a considerable burden of disease. interactions between these infections pose substantial public health challenges, especially where hiv prevalence is high and hpv vaccine coverage low.201020102630
prognostic impact of p16, p53, epidermal growth factor receptor, and human papillomavirus in oropharyngeal cancer in a betel nut-chewing area.to evaluate the prevalence of human papillomavirus (hpv) and the prognostic significance of epidermal growth factor receptor (egfr), p53, and p16 among patients with oropharyngeal carcinoma.201020479383
hiv-1 protease has a genetic t-cell adjuvant effect which is negatively regulated by proteolytic activity.hiv protease (pr) mediates the processing of human immunodeficiency virus (hiv) polyproteins and is necessary for the viral production. recently, hiv pr was shown to possess both cytotoxic and chaperone like activity. we demonstrate here that hiv pr can serve as a genetic adjuvant that enhances the hiv env and human papillomavirus (hpv) dna vaccine-induced t-cell response in a dose-dependent manner, only when codelivered with dna vaccine. interestingly, the t-cell adjuvant effects of hiv pr were ...201020484507
the spanish human papillomavirus vaccine consensus group: a working model.successful implementation of human papillomavirus (hpv) vaccine in each country can only be achieved from a complementary and synergistic perspective, integrating all the different points of view of the diverse related professionals. it is this context where the spanish hpv vaccine consensus group (grupo español de consenso sobre la vacuna vph, gec-vph) was created. gec-vph philosophy, objectives and experience are reported in this article, with particular attention to the management of negative ...201020484987
oral proliferative verrucous leukoplakia: underdiagnosed oral precursor lesion that requires retrospective clinicopathological correlation.we present herein a case of oral proliferative verrucous leukoplakia (opvl) and discuss this relatively rare entity in light of current information. a 59-year-old woman, non-smoker, presented with a verrucous plaque at the left ventral and dorsal surfaces of the tongue that she had first noticed in 2001. at that time, the plaque was excised and revealed benign hyperkeratosis. the growth recurred and was again excised. histologically it was characterized by a verrucous epithelial hyperplasia, hyp ...201020492823
efficacy of hpv 16/18 vaccines on sexually active young women and the impact on organized cervical cancer screening. 201020504086
adult women's attitudes toward the hpv vaccine.two human papillomavirus (hpv) vaccines have demonstrated efficacy in preventing hpv infection and are currently being administered to adolescent girls in several countries. although the most efficient hpv prevention strategy is immunizing adolescents before there is any risk of exposure, adult women also may benefit from vaccination. this study aimed to explore the attitudes of women aged 27-55 years toward the hpv vaccine.201020509785
polymorphism of the capsid l1 gene of human papillomavirus types 31, 33, and 35.the l1 gene encodes for the major capsid protein of human papillomaviruses (hpv). there is limited information on the polymorphism of l1 for types related to hpv-16. this report explores the polymorphism of l1 in phylogenetically related types 31, 33, and 35 compared to hpv-16. genital specimens collected from 732 hiv-seropositive and 323 hiv-seronegative women were screened for hpv dna with consensus l1 pcr. cervical samples positive for hpv-16 (n = 74), hpv-31 (n = 78), hpv-33 (n = 37), and hp ...201020513080
factors related to physicians' willingness to vaccinate girls against hpv: the importance of subjective norms and perceived behavioral control.this study assessed factors related to physicians' intentions to vaccinate patients against human papillomavirus. a random sample of physicians was surveyed. the survey questions focused on the constructs of the theory of planned behavior. structural equation modeling was used to estimate the relationship of theoretical constructs to intention to vaccinate. of the 207 physicians who responded, intentions to vaccinate were very high (86.5%). on a scale of 1 to 7 (strongly disagree to strongly agr ...201020437302
[screening of cervical cancer--update].update screening of cervical cancer.201020437841
safety, tolerability, and immunogenicity of gardasil given concomitantly with menactra and adacel.multinational phase iii trials of a human papillomavirus vaccine, gardasil, have shown the vaccine to be generally well-tolerated, efficacious, and immunogenic. we evaluated the immunogenicity and safety of gardasil administered concomitantly with menactra and adacel.201020439595
reduced mir-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection.reduced mir-34a expression is associated with high-risk human papillomavirus (hr-hpv) infection and cervical cancer. whether the reduction of mir-34a expression induced by hr-hpv e6 occurs in precancerous lesions, even before morphologic change, is still uncertain. our study aimed to ascertain the possibility of pri-mir-34a involved in the development of cervical lesions and to explore the mechanism of altered pri-mir-34a expression induced by hpv-16 e6.201020442590
the role of cytology (pap tests) and human papillomavirus testing in anal cancer screening.to assess anal oncogenic human papillomavirus (hpv) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (ain 2+), as this is an immediate anal cancer precursor.201020442633
identification of human papilloma virus type 6 in psoriasiform keratosis.psoriasiform keratosis is a recently reported unique clinicopathological entity characterized by the appearance of a solitary lesion mimicking seborrheic keratosis, actinic keratosis, or squamous cell carcinoma and histopathologic features closely resembling psoriasis. we report a 74-year-old woman presenting with a solitary, scaly lesion on the dorsum of the left arm of several months duration and histopathologic findings of psoriasiform acanthosis of the epidermis with thinning of the suprapap ...201020442638
natural history of infections with high-risk hpv in chinese women with abnormal cervical cytology findings at baseline.to clarify the natural history of disease in chinese women with benign cytologic observation and positive for high-risk human papillomavirus (hr-hpv).201020447633
detection of polyomavirus major capsid antigen (vp-1) in human pilomatricomas.the family polyomaviridae is composed of small, non-enveloped, double-stranded dna viruses widely used to study cell transformation in vitro and tumor induction in vivo. the development of pilomatricomas in mice experimentally infected with polyomavirus led us to detect the viral major capsid protein vp-1 in human pilomatricomas. this tumor, even uncommon, is one of the most frequent benign hair follicle tumors in humans and is composed of proliferating matrix cells that undergo keratinization, ...201020447899
hpv-associated head and neck cancer: a virus-related cancer epidemic.a rise in incidence of oropharyngeal squamous cell cancer--specifically of the lingual and palatine tonsils--in white men younger than age 50 years who have no history of alcohol or tobacco use has been recorded over the past decade. this malignant disease is associated with human papillomavirus (hpv) 16 infection. the biology of hpv-positive oropharyngeal cancer is distinct with p53 degradation, retinoblastoma rb pathway inactivation, and p16 upregulation. by contrast, tobacco-related oropharyn ...201020451455
attitudes and perceptions of the hpv vaccine in caribbean and african-american adolescent girls and their parents.to describe attitudes and perceptions toward acceptability of human papilloma virus (hpv) vaccination among inner city caribbean (ca) and african american (aa) adolescents and their parents, and discuss correlates that may be associated with these factors.201020452260
[increasing incidence of anal cancer in the netherlands].anal cancer is a rare malignancy with a rapidly rising incidence. the most important risk factor for anal cancer is persistent infection with human papillomavirus (hpv). in the netherlands, the incidence of anal cancer increased from 71 to 149 new patients each year over the period 1989-2006. there has been a corresponding overall increase in mortality, although the exact level differs per year. not enough research has been done to date to clarify why the incidence of anal cancer is increasing.201020456793
estrogen and eralpha: culprits in cervical cancer?estrogen and its receptors are implicated in the promotion and prevention of various cancers. although the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (hpv) infections, is poorly understood. recent studies in hpv transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with hpv oncogenes. although epidemiological studies further suppor ...201020456973
spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma.to identify functionally related prognostic gene sets for head and neck squamous cell carcinoma (hnscc) by unsupervised statistical analysis of microarray data.201020458058
clinical study of quantitative diagnosis of early cervical cancer based on the classification of acetowhitening kinetics.a quantitative colposcopic imaging system for the diagnosis of early cervical cancer is evaluated in a clinical study. this imaging technology based on 3-d active stereo vision and motion tracking extracts diagnostic information from the kinetics of acetowhitening process measured from the cervix of human subjects in vivo. acetowhitening kinetics measured from 137 cervical sites of 57 subjects are analyzed and classified using multivariate statistical algorithms. cross-validation methods are use ...201020459246
nucleic acid sequence-based amplification assay for human papillomavirus mrna detection and typing: evidence for dna amplification.human papillomavirus (hpv) e6/e7 mrna has been proposed as a more specific marker for cervical dysplasia and cancer than hpv dna. this study evaluated the rna specificity of nucleic acid sequence-based amplification (nasba)-based hpv detection using hpv dna plasmids (hpv type 16 [hpv16], hpv18, hpv31, hpv33, and hpv45) and nucleic acid extracts of several cell lines, which were systematically subjected to enzymatic treatments with dnase and rnase. hpv plasmid dilutions (10(6) to 10(0) copies/mic ...201020463156
[methods used in the identification of human papillomavirus].given the causal relationship between specific types of hpv with cervical cancer and precursor lesions, it is important to identify the viral type involved. the characterization is done by various methods that vary in sensitivity and specificity, whose use depends mainly on the aim pursued and the characteristics of the evaluated sample. hpv typing is not only important clinically for the establishment of monitoring and treatment of a patient, it also provides knowledge of the viral types circul ...201020463773
management of anal cancer in 2010. part 1: overview, screening, and diagnosis.although anal cancer is a rare disease, its incidence is increasing in men and women worldwide. the most important risk factors are behaviors that predispose individuals to human papillomavirus (hpv) infection or immunosuppression. anal cancer is generally preceded by high-grade anal intraepithelial neoplasia (hgain), which is most prevalent in human immunodeficiency virus (hiv)-positive men who have sex with men. there is a general consensus that high-risk individuals may benefit from screening ...201020464850
population fraction of cervical neoplasia attributable to high-risk human papillomaviruses.the efficacy of human papillomavirus (hpv) type 16 and 18 vaccines against cervical intraepithelial neoplasia grade ii (cin2+) has been verified, but the active follow-up of studies with invasive cervical cancer or cervical intraepithelial neoplasia grade iii (cin3) as primary end points are ethically not possible. furthermore, ongoing registry-based passive follow-up studies with invasive cervical cancer as the end point will take time.201020465386
[condylomatous cell carcinoma of the penis associated with multimetastatic human papillomavirus]. 201020470704
why do low-income minority parents choose human papillomavirus vaccination for their daughters?to explore low-income minority parents' attitudes, intentions, and actions with regard to human papillomavirus (hpv) vaccination for their daughters.201020472250
determinants of human papillomavirus infection among inuit women of northern quebec, canada.we investigated risk factors for prevalent high-risk human papillomavirus (hr-hpv) in inuit women from quebec. younger age and having 10 or more lifetime sexual partners were associated with hr-hpv. findings suggest that for older women, markers of recent sexual activity are more predictive of hr-hpv status than markers of lifetime sexual history.201020473246
adult male circumcision: will it reduce disease caused by human papillomavirus? 201020370482
metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory t lymphocytes and inhibiting tumor angiogenesis.although cancer vaccines are emerging as innovative methods for cancer treatment, these alone have limited potential for treating measurable tumor burden. thus, the importance of identifying anticancer strategies with greater potency is necessary. the chimeric dna vaccine ctgf/e7 (connective tissue growth factor linked to the tumor antigen human papillomavirus 16 e7) generates potent e7-specific immunity and antitumor effects. we tested immune-modulating doses of chemotherapy in combination with ...201020372107
our knowledge of human papillomavirus (hpv), and its role in the genesis of cervical cancer, continues to grow. 201020374606
cigarette smoking linked to increased human papillomavirus dna load. 201020375321
molecular variants of hpv type 16 e6 among honduran women.in this study, we investigated the prevalence of human papillomavirus 16 (hpv-16) variants in honduran women with normal cytology and with dysplasia and cervical cancer.201020375791
conjunctival squamous cell carcinoma due to ocular prostheses: a case report and review of literature.conjunctival squamous cell carcinoma (scc) is a rare finding in everyday clinical practice, but is the most common malignancy of the ocular surface. the incidence of this malignancy in the united states is 0.03 per 100,000 persons. it is one extreme of a spectrum of lesions encompassed in ocular surface squamous neoplasia which range from dysplasia to carcinoma in situ to invasive scc. exposure to ultraviolet radiation b (uvb), human papilloma virus (hpv), and human immunodeficiency virus (hiv) ...201020376710
morphine-sparing effect by cox-1 inhibitor sustains analgesic function without compromising antigen-specific immunity and antitumor effect of naked dna vaccine.morphine and ketorolac, two analgesics with different mechanisms, have been widely used in controlling cancer pain and postoperative pain in surgery. our previous study revealed that morphine could suppress the anti-tumor effect of antigen-specific dna vaccine. in this study, we further evaluated and compared another analgesic drug, ketorolac, with morphine for its analgesic functions and the antitumor immunities of antigen-specific dna vaccine. we first observed that ketorolac-treated mice did ...201020377998
the sociocultural context of gynecological health among haitian immigrant women in florida: applying ethnographic methods to public health inquiry.twalet deba, a culturally mediated feminine hygiene practice, is widespread in little haiti, the predominately haitian neighborhood in miami, florida. this practice may have important implications for susceptibility to sexually transmitted infections, including human papillomavirus, the principal cause of cervical cancer. previous research has not examined the full context of twalet deba in consideration of cultural beliefs and norms about women's hygiene and sexual health.201020379893
cancer prevention: major initiatives and looking into the future.cancer is one of the major causes of death in countries across the world. however, at least half of cancers could be prevented. this article reviews the relationship between cancer incidence and the major risk factors: tobacco use, exposure to infections, nutrition, obesity and physical activity. several major current cancer prevention initiatives are presented, including the effort for global tobacco control, vaccination programs for human papilloma virus, chemoprevention, and cohort studies to ...201020384561
passport to promiscuity or lifesaver: press coverage of hpv vaccination and risky sexual behavior.a significant minority of parents are concerned about adolescents engaging in risky sexual behavior following human papillomavirus (hpv) vaccination. the way the hpv vaccine is reported in the media has the potential to influence public understanding and vaccination decisions. the present study examined the content of articles published between 2003 and 2008 in british national newspapers that addressed the issue of adolescents engaging in risky sexual behavior following hpv vaccination. we used ...201020390987
distribution of human papillomavirus types in women from valencia, spain, with abnormal cytology.to determine human papillomavirus (hpv) types among cervical smears using polymerase chain reaction (pcr) and to contribute to the knowledge of human papillomavirus genotype distribution and prevalence of oncogenic types in cervical lesions in spain.201020391971
association of schistosoma haematobium and human papillomavirus in cervical cancer: a case report.the association between schistosoma haematobium and cervical cancer has been reported for a long time. however, recently human papillomavirus, a cofactor in the genesis of cervical cancer, has been confirmed. a case of squamous intraepithelial lesion after s haematobium infection is presented, and the relation between schistosomiasis, human papillomavirus and squamous intraepithelial lesion, with long-term follow-up by papanicolaou smear, is discussed.201020391981
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