Publications

salient features of haemophilus vaginalis.	a total of 78 strains of haemophilus vaginalis were examined for 104 features. all strains fermented dextrin, maltose, and starch. additionally, more than 90% of the strains fermented galactose, glucose, and ribose. arbutin, cellobiose, melibiose, rhamnose, and salicin were not fermented by any of these strains. none of the strains acidified any of 14 alcohols or alkalinized any of 25 organic salts and amides. more than 90% of the strains hemolyzed human blood agar and hydrolyzed hippurate. no s ...	1979	311779
haemophilus influenzae type d meningitis.	this report describes an unusual pathogen associated with post-traumatic meningitis. haemophilus influenzae type d was isolated from both cerebrospinal fluid and blood of this patient with meningitis.	1979	311780
the infant rat as a model for assessment of the attenuation of human influenza viruses.	the intranasal infection of infant rats with haemophilus influenzae type b can be considerably enhanced by prior infection of the rats with influenza virus. when influenza virus a/england/939/69 was used to infect the animals a minimum of 10(4-0) eid50 was required to enhance h. influenzae infection; infection with 4 x 10(6) h. influenzae bacteria was needed to reveal this enhancement and infant rats two days old at the time of virus inoculation had to be used. by this method, nine strains of in ...	1979	311833
chloramphenicol-resistant haemophilus influenzae.		1979	311886
isolated congenital asplenia: an occult case of overwhelming sepsis.		1979	312008
features of the damage produced by proflavine on transforming deoxyribonucleic acid.	proflavine formed a complex with transforming deoxyribonucleic acid (dna) from haemophilus influenzae, with optimal formation at a ratio of proflavine to dna of 0.06. the rate of dissociation of the complex by dialysis increased in the order: native, denatured, renatured dna. the transforming activity of the dna was reduced by its interaction with proflavine. this inactivation was dependent on the physical state of the dna, the proflavine concentration, and the temperature. dna that had been den ...	1979	312284
hemophilus influenza septicemia and midtrimester abortion.	a case of midtrimester septic abortion due to hemophilus influenza is discussed on the basis that the pathogeneses of the septic abortion was due to the hematogenous spread of the organism orginating from upper respiratory infection. the absence of ruptured membranes and the elevated antibody titer at the onset of the pelvic infection were in keeping with this hypothesis. additional data on the bacteriology of this organism and the probability of the occurrence of a type b organism with original ...	1979	312325
[acute bacterial arthritis in small children].		1979	312412
[bacterial flora in chronic maxillary sinusitis].		1979	312479
haemophilus influenzae type b disease in a day care center: eradication of carrier state by rifampin.		1979	312483
treatment of haemophilus influenzae type b epiglottitis.	during 1969-1977, 48 children with blood cultures proved positive for haemophilus influenzae type b epiglottitis were evaluated and treated. the fatality rate was 2%; one child died and another developed irreversible hypoxic brain damage. ninety-five percent of the children were intubated and none required tracheostomy. the endotracheal tubes remained in place for 3.3 +/- 1.5 days. short-term parenteral antimicrobial therapy, 4.0 +/- 1.4 days, was sufficient to eradicate bacteremia and prevent m ...	1979	312484
new concepts in otitis media.	pneumatic otoscopy increases the physician's diagnostic acumen. movement of the tympanic membrane is observed and measured more precisely by tympanometry and acoustic impedance. ampicillin-resistant strains of hemophilus influenzae are appearing. it is possible to detect these with deep nasopharyngeal cultures. new reports show the value of antimicrobial prophylaxis in recurrent otitis media. high-risk populations that deserve special attention are children with cleft palate and down's syndrome.	1979	312593
endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis.	the unusual occurrence of endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis was confirmed in three young children during a five-year period. in contrast to bacterial endophthalmitis attributed to other microorganisms, these three infections resolved completely within a few days with conventional antimicrobial therapy. endophthalmitis is but one of the apparently increasing number of unsuual complications that may be observed as a result of h influenzae type ...	1979	312601
lung abscess due to haemophilus influenzae type c.		1979	312602
adenoids and otitis media with effusion.	at adenoidectomy specimens for bacteriological, virological, and histological investigation were obtained from the adenoids of 144 children, 53 of whom suffered from otitis media with effusion, or frequently recurring otitis media. comparison of findings in children with ear diseases with those obtained in the rest of the material showed that hemophilus influenza was cultured from 50% of the specimens from the children with ear diseases, while only 14% of the cultures from the other children yie ...	1979	312617
acute bilateral suppurative parotitis due to haemophilus influenzae. report of two cases.	acute bilateral suppurative parotitis developed in two patients with documented cirrhosis of the liver while they were in the hospital. gram's stain and culture of purulent material obtained from the orifice of stensen's duct disclosed haemophilus influenzae as the sole isolate. both patients were treated successfully with local care and antibiotics. to our knowledge, with one possible exception, infection of the parotid gland due to this organism has not been described previously.	1979	312630
a serological study of somatic antigens from haemophilus influenzae and two related species.	somatic antigenic preparations from haemophilus influenzae strains, types a-f, and from non-capsulated h. influenzae strains obtained from the oral cavity of healthy individuals were analysed with the double-diffusion technique by means of antisera against the capsulated strains. the somatic precipitinogenic pattern of each of these strains, consisting of 12--20 lines, was very similar. in addition, the somatic antigenic pattern of one h. parainfluenzae strain and one strain tentatively designat ...	1979	312767
posttraumatic meningitis due to ampicillin-resistant hemophilus influenzae. case report.	two men who sustained skull fractures secondary to blunt head trauma developed meningitis due to hemophilus influenzae type b. the isolates in both cases were resistant to ampicillin but susceptible to chloramphenicol. based of this experience, and recent epidemiological trends, it is suggested that chloramphenicol, rather than penicillin g, might be the initial therapy of choice for posttraumatic meningitis when no micro-organisms are recognized on gram-stained smears of the cerebrospinal fluid ...	1979	312922
effect of rifampin on nasopharyngeal carriage of haemophilus influenzae type b.		1979	312927
diagnostic value of needle aspiration in haemophilus influenzae type b cellulitis.		1979	312928
treatment of ampicillin-resistant haemophilus influenzae in soft tissue infections with high doses of ampicillin.	six soft tissue infections (three epiglottitis, one cellulitis, one pneumonia, and one arthritis) with ampicillin-resistant haemophilus influenzae were treated initially with high doses of ampicillin (200 to 400 mg/kg/day intravenously) alone and had good clinical responses. all had documented bacteremia with h. influenzae. one child was treated only with ampicillin; treatment in the remainder was changed to oral therapy with other antibiotics to facilitate discharge. there was no recurrence of ...	1979	312930
pathogenesis of bacterial meningitis. studies on the route of meningeal invasion following hemophilus influenzae inoculation of infant rats.		1979	312973
acute epiglottitis in an adult.		1979	312999
haemophilus influenzae meningitis. a national study of secondary spread in household contacts.	to determine the risk of severe haemophilus influenzae illness among household contacts of patients with h. influenzae meningitis, we studied prospective data obtained in 19 states from january 1, 1977, to june 30, 1978. h. influenzae meningitis was reported in 1403 patients, and 1147 (82 per cent) of the exposed families were investigated for the occurrence of h. influenzae disease within 30 days after its onset in the index patient. during this interval, nine of 1687 household contacts (0.5 pe ...	1979	313003
is haemophilus influenzae meningitis contagious?		1979	313005
trauma-associated periorbital cellulitis due to haemophilus influenzae.		1979	313039
biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human t cell lines.	human malignant t cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. when incubated with deoxyadenosine or thymidine, the malignant t cell lines rapidly accumulate toxic concentrations of datp and dttp, respectively. this unusual pattern of deoxyribonucleotide metabolism renders the malignant t cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.	1979	313056
revised spectra for the inactivation of haemophilus influenzae transforming dna by monochromatic ultraviolet light: effect of histidine.		1979	313059
[effect of tobacco smoking and of air pollution on incidence of haemophilus influenzae in pharyngeal cavity (author's transl)].		1979	313061
hemophilus influenzae septicemia and polyarthritis in multiple myeloma.	hemophilus influenzae sepsis, rare in adults, is reported for the first time in association with multiple myeloma. the patient developed fulminant septicemia involving multiple organs and disabling pyarthrosis due to nonencapsulated h influenzae, usually considered to be nonpathogenic. early diagnosis and appropriate antibiotic therapy cured the infection and prevented permanent joint disease. also illustrated is the problem of establishing a diagnosis of myclomatosis in patients with septicemia ...	1979	313078
the taxonomy and antimicrobial susceptibility of haemophilus species in clinical specimens.		1979	313150
anaerobic and aerobic bacteriology of acute conjunctivitis.	aerobic and anaerobic cultures and clinical data were obtained from 131 patients presenting with acute conjunctivitis. similar cultures were obtained from 60 noninflamed individuals. anaerobes were isolated from 66 patients, 51 times in mixed culture with aerobes and 15 times (11.5%) as the only isolates. aerobes only were recovered in 54 patients. the organisms found to be statistically significantly more commonly recovered from eyes with conjunctivitis were staphylococcus aureus, hemophilus in ...	1979	313179
[bactericidal activity of ampicillin, chloramphenicol and gentamicin, alone or in combinations against susceptible and resistant "haemophilus influenzae" (author's transl)].	bactericidal activity of three antibiotics, ampicillin, chloramphenicol and gentamicin, alone or in combinations, was determined against susceptible and resistant strains of haemophilus influenzae. the various antibiotic combinations were studied for the determination of a synergistic or antagonistic effect. the study was done by the checkerboard method. a percentage of survivors inferior or equal to 0.01% of the inoculum represents the bactericidal activity. ampicillin and chloramphenicol are b ...	1979	315746
ly-127935: a novel beta-lactam antibiotic with unusual antibacterial activity.	the in vitro activity of ly-127935, a new beta-lactam antibiotic, was examined by using 370 clinical bacterial strains. in comparison with several other beta-lactam agents, ly-127935 was the most inhibitory against the enterobacteriaceae. it was remarkably active against multi-drug-resistant strains of enterobacter spp., serratia spp., and pseudomonas aeruginosa. ly-127935 had four- to eightfold greater activity than did cefoxitin against bacteroides fragilis. production of beta-lactamase by ent ...	1979	315753
scintigraphic findings of uncommon focal manifestations of haemophilus influenzae septicemia.	haemophilus influenzae septicemia is usually associated with a clinical focus of infection. the investigators describe early scintigraphic findings in some uncommon manifestations of h. influenzae septicemia.	1979	315856
mitral valve replacement in infective endocarditis as prophylaxis against embolism. identification of patients at risk by 2-dimensional echocardiography.	a 36-yr-old woman and a 46-yr-old man had infective endocarditis of the mitral valve. examination by 2-dimensional dynamic echocardiography demonstrated large mobile vegetations in both patients, and the display pointed to an ominous risk of embolism. heart surgery with valve replacement was performed, the main indication being prophylaxis against embolism; the operative findings seemed to justify the assumption of imminent risk of embolism. it is suggested that the display of dynamic morphology ...	1979	315876
ceforanide (bl-s786) in the treatment of community-acquired bacterial pneumonia.	ceforanide (bl-s 786) is a new long-acting parenteral cephalosporin which has the major pharmacologic advantage of requiring only twice a day dosage. we treated 28 adult patients with community-acquired bacterial pneumonia using doses of 500 or 1000 mg every 12 hours. twenty-four of 28 infections were due to streptococcus pneumoniae and/or hemophilus influenzae, and all pathogens were susceptible in vitro to both cephalothin and ceforanide. patients were treated for a mean of 7.5 days, and all s ...	1979	315929
serum and sputum antibiotic levels after ampicillin, amoxycillin and bacampicillin chronic bronchitis patients.	serum and sputum concentrations of ampicillin or amoxycillin were measured in patients admitted to hospital for acute exacerbations of chronic bronchitis with purulent sputum. mean peak serum levels of nearly 12 mg/l were found after 1600 mg bacampicillin (mean peak level in sputum 0.85 mg/l). the serum and sputum concentrations after 750 mg amoxycillin and 800 mg bacampicillin were comparable (mean peak serum levels approximately 9.5 mg/l, sputum concentrations 0.4 to 0.5 mg/l) although the dru ...	1979	315930
a clinical comparison of ampicillin, ampicillin esters (bacampicillin and pivampicillin) and amoxycillin in acute exacerbations of chronic bronchitis.	the results of antibiotic therapy in 271 patients suffering from acute exacerbations of chronic bronchitis are presented. the effectiveness of the better absorbed ampicillin esters (pivampicillin and bacampicillin) is confirmed, but side-effects from the pivampicillin present problems whereas bacampicillin is excellently tolerated, even in twice daily doses of 1600 mg. amoxycillin, if given in 750 mg doses three times daily by mouth, is also safe and effective against haemophilus influenzae. how ...	1979	315931
biotypes of haemophilus encountered in clinical laboratories.	the biochemical characteristics of 464 strains of haemophilus influenzae and 83 strains of haemophilus parainfluenzae isolated over an 18-month period are described. of 22 characteristics obtained, only 6 were necessary to biochemically identify and biotype the isolates. the key substrates or tests were urease, ornithine, indole, o-nitrophenyl-beta-d-galactopyranoside, sucrose, and xylose. five biotypes of h. influenzae and four of h. parainfluenzae were commonly recognized. some strains were en ...	1979	315964
use and interpretation of schlichter's test on haemophilus influenzae: relation of in vitro to in vivo results for cefamandole.	when haemophilus influenzae infections are treated by an antibiotic acting on the bacterial wall, the adequacy of antimicrobial therapy can be assessed by schlichter's test. this test may be carried out using mueller hinton broth (or mueller hinton broth with 50% pooled serum and a supplement of ca++ and mg++) supplemented with fildes' enrichment and an inoculum adjusted to the 0.5 mcfarland turbidity standard diluted 200x. however, correct reading of end points can be obtained only by phase con ...	1979	315967
simplified media for the growth of haemophilus influenzae from clinical and normal flora sources.	the nutritional requirements of 43 strains of haemophilus influenzae isolated from clinical and normal flora sources were investigated. two defined minimal media were developed by modifying the medium of herriott et al. (1970):74% of the strains could grow on the minimal media and herriott's medium; the remaining strains could not grow on any of these media.	1979	315998
acute purulent conjunctivitis in nigerian children in zaria.	a prospective study of 61 acute purulent conjunctivitis seen in children up to 10 years of age at the ahmadu bello university hospital, zaria, nigeria, between october 1975 and september 1976 showed h influenzae as the most common etiologic agent (26.2%), followed by s aureus (16.4%), n gonorrhoeae (14.8), and d pneumoniae (9.8%). n gonorrhoeae was the most common cause of conjunctivitis in the first month of life (43.8%) followed by s aureus (37.5%). conjunctivitis from h influenzae occurred in ...	1979	316007
a hex mutant of haemophilus influenzae.	a mutant of haemophilus influenzae which does not discriminate between low efficiency (le) and high efficiency (he) markers has been isolated. the mutant does not differ wild type in its sensitivity to ultraviolet radiation, methyl methanesulfonate (mms) mitomycin c, and nitrous acid. spontaneous mutation frequencies for three loci studied are 10- to 30-fold higher in the mutant than in the wild type strain. low- and high-efficiency transforming markers are equally uv-resistant when assayed on t ...	1979	316097
secondary spread of h. influenzae.		1979	316106
antimicrobial resistance of haemophilus species in patients with chronic bronchitis.	haemophilus influenzae strains resistant to ampicillin have become an important cause of disease in pediatric patients. because many adults with chronic bronchitis carry haemophilus organisms in their tracheobronchial tree and because antimicrobial agents are used commonly in these patients, we assessed the prevalence of resistance to ampicillin and other antimicrobial agents in this population. we studied 150 haemophilus isolates (73 h. influenzae, 69 h. parainfluenzae, 6 h. parahemolyticus, an ...	1979	316298
effect of inoculum size on the susceptibility of haemophilus influenzae b to beta-lactam antibiotics.	the current prevalence of ampicillin-resistant haemophilus influenzae b meningitis requires accurate knowledge of susceptibility to alternative antibiotics. one variable affecting susceptibility is inoculum size. we studied the susceptibility of 200 clinical isolates of h. influenzae b to ampicillin, carbenicillin, and cefamandole at inocula of 10(5) and 10(7) cfu by two techniques. fifty ampicillin-susceptible and fifty ampicillin-resistant strains were tested for susceptibility to ampicillin b ...	1979	316308
waterhouse-friderichsen syndrome caused by haemophilus influenzae type b.		1979	316349
ampicillin-resistant hemophilus influenzae in canada: nationwide survey of hospital laboratories.		1979	316354
clinical and pharmacological evaluation of different preparations of oral erythromycin.	the activity of erythromycin stearate in respiratory tract infections was evaluated. this study involved 269 out-patients. of these, 76 satisfied the strict criteria for detailed bacteriological study with positive cultures of a known pathogen before treatment and bacteriological follow-up after treatment. the results of erythromycin stearate were good against the haemolytic streptococcal infections. the activity of this antibiotic was shown to be insufficient against haemophilus influenzae. a s ...	1979	316377
counter current immunoelectrophoresis in the diagnosis of haemophilus influenzae meningitis in children.		1979	316423
meningitis due to haemophilus influenzae type e biotype 4.	haemophilus influenzae type e biotype 4 was isolated from the cerebrospinal fluid of a 16-month-old child with meningitis. this is the first isolation, from a case of meningitis, of this organism that has been biotyped.	1979	316434
infectious arthritis due to hemophilus influenzae.	a healthy 51-year-old male developed multiarticular infectious arthritis due to hemophilus influenzae, a rare cause of infectious arthritis in adults. previous case reports are reviewed. predisposing factors include chronic illness, underlying joint disease, joint trauma, and respiratory infection. h. influenzae is frequently misidentified on gram stain, being mistaken for gonococci or pneumococci. infections due to h. influenzae may occur in normal adults. aspects of immunity are discussed.	1979	316460
[acute dyspnoea by acute thyroid abscess (author's transl)].	infection is extremely rare in the pathology of the thyroid gland. one case is reported, and a review of the literature has helped to emphasize some specific points. acute thyroiditis can be misdiagnosed in its initial phase because a fever by itself may not lead to a through examination of the neck, even if a goitre is present; the latter being the site of infection in the case reported. dyspnoea of laryngeal origin proves to be a dangerous complication of thyroid abscesses. treatment is always ...	1979	316655
structural studies of the capsular antigen of haemophilus influenzae type c.	the structure of the capsular antigen from haemophilus influenzae type c has been investigated, n.m.r. spectroscopy being the principal method used. it is concluded that the antigen is composed of repeating-units having the following structure: formula: (see text). o-acetyl groups are present in approximately 90% of the repeating-units.	1979	316727
experimental smallpox in chimpanzees.	in an attempt to prepare highly specific antiserum to variola virus, a chimpanzee was inoculated with a virulent human strain of this virus. three uninoculated chimpanzees were housed in the same room; two of these developed clinical disease with seroconversion, while the third developed no evidence of infection and no antibody. the three animals that became ill also developed antibody to vaccinia and monkeypox viruses. human contacts during the study and following a break in containment showed ...	1979	316740
hearing impairment following therapy of haemophilus influenzae meningitis.	from 97 children with bacteriologically confirmed haemophilus influenzae meningitis, 39 were treated with chloramphenicol (before 1970) and 58 with ampicillin (since 1970). in 1977 all patients were followed up with history, clinical examination, and audiometry. sensorineural hearing defect was found in 5 chloramphenicol patients and in 10 ampicillin patients. of the 82 patients for whom treatment was begun within 48 h of onset of symptoms, only two showed hearing deficit, while 13 of the 15 pat ...	1979	316810
[etiologic diagnosis of pleuropulmonary suppurations in children].		1979	316851
[2 cases of septic arthritis caused by haemophilus influenzae].		1979	316941
epiglottis acuta treated with nasotracheal intubation.	twenty children, ranging in age from 1--9 years, and one adult suffering from epiglottis acuta were treated with nasotracheal intubation performed under general anaesthesia and with ampicillin. clinical cure was obtained in all cases with a mean intubation time of 34 hours. the diagnosis, epiglottis acuta, was suspected by the referring physician in 10 cases. the incidence of epiglottis acuta compared to laryngitis acuta was found to be 1:30. the mean hospital stay was 5.4 days. it is concluded ...	1979	316956
[septicemia and meningitis due to hemophilus parainfluenzae in a newborn infant].		1979	317063
combined action of chloramphenicol and ampicillin on haemophilus influenzae.		1979	317078
precipitating antibodies against haemophilus influenzae and staphylococcus aureus in sputum and serum from patients with cystic fibrosis.	serum and sputum sol phase from 23 patients with cystic fibrosis (cf) were examined for occurrence and titres of precipitins against haemophilus influenzae and staphylococcus aureus by means of crossed immunoelectrophoresis with intermediate gel. the patients had from four to nine h. influenzae precipitins in serum and in most cases fewer precipitins in sputum, but, on an average, there was no difference between the titres of the antibodies in serum and sputum. most of the antibodies were cross- ...	1979	317211
unusual features of hemophilus infections in adults.	infections due to species of hemophilus, especially h influenzae type b, are usually equated with the pediatric age group. however, during the past several years the medical literature has emphasized the occurrence of such infections in adults. four adult patients are presented who demonstrate certain unique clinical features which have not been recently or previously reported.	1979	317222
haemophilus influenzae tenosynovitis.	a case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by haemophilus influenzae type b. the clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. as the management of the h. influenzae tenosynovitis would differ from that due to other causes, the addition of h. influenzae type b to a differential of tenosynovitis should be considered. recognition and prompt treatment by appropriate antibiotics may ...	1979	317240
[pneumonia due to hemophilus influenzae b].		1979	317263
absence of increasing incidence of meningitis caused by haemophilus influenza type b.	an epidemiologic survey of meningitis caused by haemophilus influenzae type b in children aged zero to four years during an 11-year period (january 1965-december 1975) was conducted in the baltimore, maryland, metropolitan area to examine recent trends in the incidence of this disease. cases of h. influenzae meningitis were identified at all 19 hospitals in the city and county of baltimore and all 41 hospitals in the surrounding area. the population at risk (age, zero to four years) was estimate ...	1979	317292
the incidence of post-splenectomy sepsis and herpes zoster in children and adolescents with hodgkin disease.	the occurrence of sepsis due to streptococcus pneumoniae and hemophilus influenza and of herpes zoster (hz) was reviewed in a series of 72 consecutive, previously untreated children and adolescents with hodgkin disease. there was not a statistically significant difference in the risk of developing sepsis within five years of diagnosis between patients who had (16.6%) or had not (6.2%) undergone splenectomy. sepsis occurred most frequently among patients treated initially with total nodal irradia ...	1979	317350
the management of chronic bronchitis.		1979	317356
[antibodies against haemophilus influenzae and immunoglobulins igg, iga, igm and ige in the blood serum of patients with chronic bronchitis (author's transl)].		1979	317519
[different mechanisms of resistance to ampicillin in strains of haemophilus influenzae].		1979	317526
serotypes and biotypes and antibiotic susceptibility of haemophilus influenzae encountered in a clinical laboratory in taiwan.	forty-four serologically and biochemically typable haemophilus influenzae isolates from clinical specimens in taiwan were subjected to analysis in their relationship with source of isolation and age distribution. it was found that all isolates from blood and cerebrospinal fluid were serotype b, biotype i, and all were in children less than 4 years of age. serotypes b and e, biotypes i and iii were encountered to have the highest incidence of infection caused by h. influenzae in this area. all h. ...	1979	317580
chemical composition and biological activities of a phenol-water extract from haemophilus influenzae type a.	ribonucleic acid was removed from a phenol-water extract of haemophilus influenzae type a by streptomycin sulfate. this preparation was called purified preparation or pp. it contained neutral sugars (glucose, galactose, mannose, pentose), glucosamine, amino acids, and fatty acids. heptose and 2-keto-3-deoxyoctonic acid were not present. the biological properties and immunogenicity were compared with the activities of lipopolysaccharide of escherichia coli or salmonella typhimurium. higher doses ...	1979	317593
[clinical considerations on cerebral abscesses].		1979	317774
[in vitro activity of cefaclor against haemophilus influenzae in comparison to various oral chemotherapeutic agents (author's transl)].	the antibacterial activity of cefaclor against 100 non-beta-lactamase producing and 11 beta-lactamase producing isolates of haemophilus influenzae was compared with that of cephalexin, ampicillin, chloramphenicol, tetracycline and co-trimoxazole. a new standardized microtiter dilution technique was used. cefaclor showed greater activity than did cephalexin and inhibited beta-lactamase producing h. influenzae isolates. ampicillin was the most active compound against non-beta-lactamase producing i ...	1979	317812
infectious disease management with oral antibiotics.	this paper has reviewed the bacterial etiologies and therapeis for commonly seen infections in the out-patient clinic or physician's office. the use of oral antibiotics for the treatment of pharyngitis, otitis media, sinusitis, bronchitis, certain pneumonias, cellulitis, urinary tract infections and as follow-up therapy to systemic administration is discussed. emphasis on the decreasing bacterial spectra of the tetracyclines is noted as well as a discussion of therapy of infections due to beta-l ...	1979	317813
cefaclor in the treatment of susceptible infections in infants and children.	fifjty-two outpatients, aged from six months to 17 years, and suffering from group a streptococcal pharyngitis, skin and soft tissue infection, urinary tract infection, or otitis media were enrolled in the study. the dosage of cefaclor was 20 to 40 mg/kg/day in three or four divided doses for ten days. in 43 children given either cefaclor suspension or capsules, plasma level estimations were performed. cefaclor readily produces therapeutic plasma levels in children. cefaclor appears to be a safe ...	1979	317814
chloramphenicol-resistant haemophilus influenzae.		1979	318547
chloramphenicol and phenobarbitone--a drug interaction.	two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. a standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. the importance of measuring serial blood chloramphenicol concentrations is stressed.	1979	311186
comparison of vaccination of mice and rats with haemophilus influenzae and bordetella pertussis as models of atopy.	1. rats and mice were vaccinated with haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. in rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after bordetella pertussis vaccination. in a long-term vaccination schedule (five times a week for 5 weeks) rats developed a constant eosinophilia. in mice a single vaccination resulted in an eosinopenia of a consistent pattern whic ...	1979	311260
modification of dna in chromatin with methyltransferase from haemophilus influenzae rd.	the accessibility of dna in nucleosome dimers (as a model of the chromosomal chain of nucleosomes) was determined by means of modification methylases from haemophilus influenzae rd. using these enzymes, the rate of modification of nucleosome dimers is about one fifth the rate observed with protein-free dna from chromatin subunit dimers. methylated dna sites in nucleosome dimers are readily accessible to micrococcal nuclease. the analysis of the fragment pattern of nucleosomes after methylation a ...	1979	311284
sequence-specific dna uptake in haemophilus transformation.	haemophilus cells efficiently take up haemophilus dna from the medium during transformation but do not take up other dnas. to study the mechanism of this specificity we have cloned an 8.1-kilobase (kb) fragment of h. parainfluenzae dna in the escherichia coli--pbr322 host--vector system and reisolated the dna fragment for use as a defined probe. the 5'32p end-labeled 8.1-kb dna is efficiently absorbed by competent haemophilus cells whereas vector dna present in the mixture is not, implying that ...	1979	311478
possible postinfectious immune arthritis: haemophilus influenzae type b.		1979	311582
haemophilus influenzae cellulitis in an adult.	cellulitis due to haemophilus influenzae type b in adults has only recently been reported. we report a case in which the patient's antibody levels documented an immunologic response to the organism. the efficacy of a new cephalosporin antibiotic, cefoxitin sodium, in treating this infection also was established. cefoxitin has activity against ampicillin-resistant h influenzae and would be an alternative in treating h influenzae cellulitis.	1979	311624
haemophilus influenzae as a cause of brodie's abscess in an infant.	brodie's abscess is a form of subacute osteomyelitis which is defined by a particular constellation of clinical, radiological and pathological features. its occurrence in infants is extremely rare. this case documents just such an occurrence. to our knowledge, the pathogen haemophilus influenzae has not been previously recognized as a cause of brodie's abscess in particular or subacute osteomyelitis in general. the clinical presentation and diagnostic pitfalls which may be encountered in this ag ...	1979	310910
haemophilus influenzae infections in adults: report of nine cases and a review of the literature.	haemophilus influenzae is an aerobic pleomorphic gram-negative coccobacillus that requires both x and v factors for growth. it grows poorly, if at all, on ordinary blood agar unless streaked with staph. aureus. it grows well on chocolate agar. because this medium is often not used in culturing specimens from adults and because the organism may be overgrown by other bacteria, the frequency of h. influenzae infections has undoubtedly been seriously underestimated. this is aggravated by the failure ...	1979	310943
cefamandole and cefoxitin.		1979	310945
chemotherapy of pneumonias.		1979	368330
severe infection due to streptococcus pneumoniae in asplenic renal transplant patients.	the medical records of 293 patients who underwent renal transplantation were analyzed for the occurrence of streptococcus pneumoniae and haemophilus influenzae infections in relation to splenectomy. splenectomy was done in 236 (81%) graft recipients before or concomitant with transplantation. bacteremia developed in five and fulminant sepsis in two from 3 to 32 months after splenectomy. no serious infections with these organisms occurred in the nonsplenectomy group. these results suggest that as ...	1979	368440
[determination of fetal infectious risk by bacteriological examination of the amniotic fluid after premature rupture of the membranes].	amniotic fluid was obtained per vagina from 228 mothers with premature rupture of the membranes and examined bacteriologically. the aim was to assess the importance of amniotic fluid contamination and the risk of foetal infection in the absence of systematic antibiotic therapy in the mothers. the incidence of amniotic fluid contamination was apparently greater in those mothers who had received antibiotics although the proportion of neonates with a true infection (3%) was almost identical. the ab ...	1979	375864
chlorpromazine inhibits phagocytosis and exocytosis in rabbit polymorphonuclear leukocytes.		1979	375938
many bacterial species bind human igd.	forty-four bacterial strains belonging to 19 species were tested for their igd-binding capacity by incubation with radiolabeled human igd. a high binding of igd to neisseria catarrhalis and hemophilus influenzae and a moderate binding of igd to streptococci of the groups a, c, and g were found. two strains of n. catarrhalis were tested for their ability to bind selectively the igd in normal pooled serum and in three serum samples with igd m components and were found to possess this property. bin ...	1979	376718
nucleotide sequence specificity of restriction endonucleases.		1979	377492
lymphocytes of adenoid tissue.	adenoid tissue was obtained at operation from 27 children admitted for adenoidectomy and from 6 controls. the occurrence of cells with cytoplasmic immunoglobulin was studied semiquantitatively by immunofluorescence microscopy of tissue sections, by which localization, number of cells and class of immunoglobulin were determined. no differences were found between patients and controls. cells isolated from adenoid tissue were compared with mononuclear leukocytes obtained from the blood. more b lymp ...	1979	377903
the specific uptake of cloned haemophilus dna.		1979	378229
cleavage sites of restriction endonucleases ecori, bamhi and hindiii on chicken embryo rdna.		1979	378708
bacterial tracheitis.	during a 14-month period, eight infants and children were observed with an acute, infectious, upper airway obstructive disease with features common to both croup and epiglottitis. we have termed this distinct entity "bacterial tracheitis." all patients failed to respond to treatment for croup, including racemic epinephrine delivered by intermittent positive-pressure breathing. direct laryngoscopy consistently revealed a normal epiglottis and aryepiglottic folds but marked subglottic mucosal edem ...	1979	379379
[standardised antibiotic therapy in major lung surgery (author's transl)].	sputum and bronchial biopsies and smears were obtained from 221 patients who had undergone partial pneumonectomy without preceding antibiotic therapy. the results of 343 sputum examinations and of 126 bacteriological examinations of biopsies and smears were evaluated. pathogenic bacteria were demonstrated in about 50% of the sputa and in about 25% of the biopsies and swabs. anaerobic micro-organisms were extremely rare. treatment was with tetracycline. before antibiotic therapy haemophilus influ ...	1979	379853
antibody activity in otitis media with effusion.	bacteria were isolated from a high percentage of the effusions from patients with otitis media with effusion (ome, serous otitis media). in an attempt to determine if the isolated bacteria were involved in the disease process, we analyzed the serum and effusion of 25 ome patients for the presence of antibacterial antibodies by the indirect immunofluorescence antibody method. specific antibody activity was detected in 20 of 25 effusions (80%) and 19 of 22 sera (86%). igg antibodies were the most ...	1979	380443
[results of 200 renal transplantations (author's transl)].	two hundred renal transplantations were performed on 187 patients between july, 1972 and june, 1978. on a follow-up of 6--78 months the survival rate after allogenic transplantation was 80% at one year and 64% at five years. satisfactory renal function was present in 62% at one year and 31% at six years. gastrointestinal complications were common and caused about 40% of all deaths. severe infections were the second most common cause of death. local complications required explantation in 4%, and ...	1979	380956