Publications

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common abnormal results of pap and human papillomavirus cotesting: what physicians are recommending for management.to evaluate the association between physician and practice characteristics and adherence to management guidelines to better understand the factors associated with different screening recommendations by primary care physicians.201021099599
projecting the need for gynecologic oncologists for the next 40 years.to estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the united states over the next 40 years.201021099604
rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women.to describe the natural history of cervical intraepithelial neoplasia (cin) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.201021099605
inhibition of cervical cancer cell growth in vitro and in vivo with dual shrnas.rna interference (rnai)-based gene silencing is widely used in laboratories for gene function studies and also holds a great promise for developing treatments for diseases. however, in vivo delivery of rnai therapy remains a key issue. lentiviral vectors have been employed for stable gene transfer and gene therapy and therefore are expected to deliver a stable and durable rnai therapy. but this does not seem to be true in some disease models. here, we showed that lentivirus delivered short-hairp ...201021102424
human papillomavirus genotype distribution in cervical samples collected in routine clinical practice at the nantes university hospital, france.objective: the objective was to assess the human papillomavirus (hpv) overall and type-specific prevalence in smears collected during routine clinical practice. design: hpv genotyping and smears were performed independently between 2000 and 2006 for routine clinical follow-up (primary screening and follow-up) in the university hospital of nantes, france. population: all women with a cytological sample collected no more than 12 months before hpv genotyping were included. methods: pcr was performe ...201021107591
corrigendum to "the potential cost-effectiveness of adding a human papillomavirus vaccine to the cervical cancer screening programme in south africa" [vaccine 27 (2009) 6196-6202]. 201020600485
human papillomavirus-like particles vaccine efficiently produced in a non-fermentative system based on insect larva. 201020600940
are women with lupus at higher risk of hpv infection?human papillomavirus (hpv) is the etiological agent of cervical cancer, the second most prevalent neoplasia among women. although it has been proven that systemic lupus erythematosus (sle) patients have higher frequency of cervical dysplasia, few studies have focused on hpv prevalence among them. this study aimed to investigate hpv prevalence among sle patients and to evaluate associated risk factors, including the use of immunosuppressors (im). total dna extracted from cervical samples of 173 s ...201020605875
no association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in brazilian women.although oncogenic human papillomavirus (hpv) infections have been established as the necessary cause of cervical cancer, most hpv infections are transient and rarely progress to squamous cervical lesions. the activity of hpv is tightly associated with epithelial cell differentiation; therefore, regulators of differentiation, such as retinoic acid (ra), have been considered targets for the prevention of hpv-associated squamous intraepithelial lesion (sil) development. the purpose of this study w ...201020606041
efficacy of human papillomavirus type 16/18 as04-adjuvanted vaccine in japanese women aged 20 to 25 years: final analysis of a phase 2 double-blind, randomized controlled trial.human papillomavirus (hpv) type 16/18 as04-adjuvanted vaccine was shown to be highly immunogenic and generally well tolerated in the interim analysis of a phase 2 double-blind, randomized controlled multicenter study in japanese healthy women aged 20 to 25 years. vaccine efficacy, immunogenicity, and safety are assessed in this study through 24 months after the first vaccination.201020606533
[verrucous carcinoma of penis: a case report].we report a case of verrucous carcinoma of the penis. a 62-year-old man, who presented with penile swelling and pain, was referred to our hospital. although, penile tumor biopsy revealed no evidence of malignancy, the patient presented with penile swelling and discharge. the penis was surgically resected and urinary diversion was performed. the pathological examination of the resected glans revealed verrucous carcinoma of penis. furthermore, in situ hybridization revealed human papilloma virus ( ...201020610928
expression of hpv6b l1/ebv lmp2 multiepitope and immunogenicity in mice.human papillomavirus (hpv) major capsid protein l1 is an important vehicle for the delivery of epitopes. to investigate the expression and immunogenicity of hybridized hpv6b l1 containing multiepitope of epstein-barr virus (ebv) latency membrane protein 2 (lmp2), a recombinant plasmid pcdna3.1(+) containing mammalian codon-optimization hpv6b l1 gene and ebv lmp2 multiepitope was constructed. the ebv lmp2 multiepitope containing t- and b-cell epitope-rich peptides was inserted into c-terminal of ...201020705592
evaluation of quality control procedures in an oesophageal cancer cohort study in anyang, china.we wished to evaluate the efficiency of internal quality control procedures of a cohort study investigating human papilloma virus (hpv) infection as a key exposure factor in oesophageal cancer in anyang, china. this was done by testing 2395 environmental/equipment swab and mock quality control samples from 14 loci on sample collection equipment for human β-globin and hpv dna. human β-globin was present in 3.88% of these samples but no hpv dna was detected. there was no evidence of hpv dna contam ...201020708302
voluntary school-based human papillomavirus vaccination: an efficient and acceptable model for achieving high vaccine coverage in adolescents. 201020708557
how parents hear about human papillomavirus vaccine: implications for uptake.to examine correlates of human papillomavirus (hpv) vaccine awareness and information sources in a state requiring schools to inform parents about hpv vaccine.201020708571
primary carcinoma of the vagina.in this paper we reviewed the risk factors for primary carcinoma of the vagina (pcv), diagnostic and therapeutic modalities, and principles leading to rational decision-making in the individualized management of vaginal carcinoma patients. the review was based on the recent literature and our own years- long experience with the disease. pcv is a rare gynecologic malignancy accounting for about 2% of all neoplasms of the female genitals. most of the affected women are over 60 years of age, peakin ...201020658716
hpv e6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (pe) from pinellia pedatisecta schott in vitro.to evaluate the cytotoxicity and apoptosis induction effects of a novel lipid-soluble extract (pe) from pinellia pedatisecta schott on caski, hela and hbl-100 cells. particularly, the effect of pe on hpv e6 gene expression was tested, and the mechanism of its apoptosis induction effect was also studied.201020659543
special commentary: patient safety and the next generation of hpv dna tests.human papillomavirus (hpv) testing is more sensitive for the detection of cervical precancer and cancer than cervical cytology. the increased sensitivity of hpv testing and cytology combined ("cotesting") compared to cytology alone permitted professional societies to recommend 3-year screening intervals among the cotest-negative results. however, there is an increasing recognition that both clinical sensitivity and specificity of cervical cancer screening are important to patient safety and must ...201020660320
prevention of human papilloma virus infection with vaccines.human papilloma virus (hpv) is present in all the cases of cervical cancer. it can also cause other diseases like genital warts, condylomata accuminata, cervical intraepithelial neoplasia and anogenital cancers. cervical cancer is the second most common cause of death from cancer. to improve the mortality from cervical cancers it is extremely important to prevent the hpv infection. in this review we have discussed the role of hpv vaccines in preventing the hpv infections and so the cervical canc ...201020726203
human papillomavirus in ameloblastoma.ameloblastomas are benign epithelial tumors of odontogenic origin, with a high recurrence rate and local aggressiveness. a few preliminary studies have demonstrated hpv presence mainly in peripheral ameloblastomas. the purpose of this study was to detect hpv-dna in intraosseous ameloblastomas.201020727492
seroprevalence and determinants of eight high-risk human papillomavirus types in homosexual men, heterosexual men, and women: a population-based study in amsterdam.to determine differences in the seroprevalence of high-risk human papillomavirus (hrhpv) types between men having sex with men (msm), heterosexual men and women, we analyzed seroprevalence and risk factors for 8 hrhpv in the general population of amsterdam, the netherlands.201020729796
human papillomavirus infection and anal dysplasia in renal transplant recipients.immunosuppression is a known risk factor for anal human papillomavirus (hpv) disease, including anal squamous cell carcinoma. additional risk factors for hpv-related disease have not been studied in the renal transplant population. the demographics of anal hpv and associated risk factors were investigated in this population.201020730855
modification of human papillomavirus minor capsid protein l2 by sumoylation.the human papillomavirus (hpv) minor capsid protein l2 plays important roles in the generation of infectious viral particles and in the initial steps of infection. here we show that hpv-16 l2 protein is sumoylated at lysine 35 and that sumoylation affects its stability. interestingly, the sumoylated form of l2 cannot bind to the major capsid protein l1, suggesting a mechanism by which capsid assembly may be modulated in an infected cell. additionally, l2 appears to modulate the overall sumoylati ...201020739540
human papilloma virus persistence and neopterin, folate and homocysteine levels in cervical dysplasias.objective: to investigate the relationship between human papilloma virus (hpv) infection persistence and serum folate, vitamin b12, homocysteine, neopterin levels in cervical dysplasia. study design: through the years 2007-2008, 122 women who have admitted to gynecology clinic were evaluated for cervical cytology, demographical characteristics, hpv infection, serum folate, vitamin b12, homocysteine, albumin, and neopterin levels. results: considering all the cases, the highest percentage of the ...201020740364
local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata.local hyperthermia has been successfully used in the treatment of viral warts by mechanisms that have largely remained unclear. using an organotypic culture system, we found that hyperthermia at 42 °c and 45 °c could induce a significant increase in the transcriptional expression of interferon (ifn)-α, ifn-β and ifn-γ, in a temperature-dependent manner in condyloma acuminata (ca), but not in normal skin. accordingly, local hyperthermia could enhance the expression of 2'-5' oligoadenylate synthas ...201020797409
treatment of genital warts: facts and controversies.there are two opposing approaches in the treatment of genital warts: (1) the traditional approach advocates complete elimination of all lesions, and (2) a second approach regards condyloma as merely a cosmetic nuisance. after a long journey through many arguments and scientific papers, we have concluded that many unknowns, uncertainties, and controversies concerning the value of treatment of genital warts in terms of clearing and curing the disease (ie, eradicating the viruses, preventing cancer ...201020797516
middle- and high-school health education regarding adolescent vaccines and human papillomavirus.we performed a mail-based survey of health education teachers in 6 states with diverse health education environments to better understand health education curricula in secondary schools related to adolescent vaccination and human papillomavirus (hpv) infection. of the 198 respondents (response rate 68%), 66% and 71% reported teaching adolescents about recommended vaccines and hpv, respectively. middle schools were significantly less likely to include these topics in their health curriculum than ...201020801244
evaluation of atypical squamous cells on conventional cytology smears: an experience from a screening program practiced in limited resource settings.the bethesda system (tbs) 2001 has subdivided the category of atypical squamous cells (asc) into: asc-us (undetermined significance) and asc-h (cannot exclude high-grade squamous intraepithelial lesion (hsil)). the present study is an analysis of asc-us and asc-h cases diagnosed in a screening program practiced in limited resource settings.201020806086
reasons for non-vaccination against hpv and future vaccination intentions among 19-26 year-old women.despite cdc recommendations regarding universal catch-up vaccination against human papillomavirus (hpv), only about ten percent of young adult women in the united states have been vaccinated. the purpose of this study was to better understand reasons for non-vaccination among insured 19-26 year-old women and to evaluate future vaccination intentions.201020809965
re: impact of human papillomavirus (hpv)-6/11/16/18 vaccine on all hpv-associated genital diseases in young women. 201020811003
safety and immunogenicity of the quadrivalent human papillomavirus vaccine in hiv-1-infected men.human immunodeficiency virus type 1 (hiv-1)-infected men are at increased risk for anal cancer. human papillomavirus (hpv) vaccination may prevent anal cancer caused by vaccine types.201020812850
hpv-16 e5 down-regulates expression of surface hla class i and reduces recognition by cd8 t cells.hpv-16 is the major causes of cervical cancer. persistence of infection is a necessary event for progression of the infection to cancer. among other factors, virus persistence is due the viral proteins fighting the immune response. hpv-16 e5 down-regulates mhc/hla class i, which is much reduced on the cell surface and accumulates in the golgi apparatus in cells expressing e5. this effect is observed also in w12 cells, which mimic early cervical intraepithelial progression to cervical cancer. the ...201020813390
presence of human papillomavirus infection determined by hybrid capture assay in cervical lesions in a venezuelan population.the aim of this study was to establish the presence of hpv infection in cervical lesions in a venezuelan population, by hybrid capture assay ii (hca ii), and its association with cytological diagnosis. the study included 1483 cervical samples analysed at laboratorios citomed, caracas, venezuela, from 2005 to 2007. the woman age range was between 20 and 58 years, and the mean age was 28.8. hpv infection was determined using hca ii. the cytological diagnosis of the smears showed lsil in 1120/1483 ...201020815154
tumor therapy in mice by using a tumor antigen linked to modulin peptides from staphylococcus epidermidis.staphylococcus epidermidis releases a complex of at least four peptides, termed phenol-soluble modulins (psm), which stimulate macrophages to produce proinflammatory cytokines via activation of tlr2 signalling pathway. we demonstrated that covalent linkage of psm peptides to an antigen facilitate its capture by dendritic cells and, in combination with different tlr ligands, can favour the in vivo induction of strong and persistent antigen-specific immune responses. treatment of mice grafted with ...201020817012
[clinical features and prognosis of cervical cancer in young women].to investigate the prevalence, etiology, clinical presentation and pathological features, treatment and prognosis of cervical cancer in young women.201020818083
age-specific prevalence of human papillomavirus by grade of cervical cytology in tibetan women.human papillomavirus (hpv) is believed to be the most common sexually transmitted infection. however, little is known about the prevalence and distribution of hpv types in china. we aimed to assess the prevalence and the distribution of hpv types as well as risks for abnormal cervical cytology in women who reside in the tibetan autonomous region of china.201020819533
disparities in human papillomavirus vaccine series initiation among adolescent girls enrolled in florida medicaid programs, 2006-2008.to better understand the human papillomavirus (hpv) vaccine series initiation among 9-17-year-old female medicaid beneficiaries in florida programs between june 2006 and december 2008 (n = 237,015).201020864008
medical and surgical approaches to vulvar intraepithelial neoplasia.vulvar intraepithelial neoplasia (vin) is a precursor to invasive vulvar carcinoma. the two major types of vin, usual and differentiated, differ in epidemiology, pathogenesis, clinical manifestations, pathology, and malignant potential. usual vin commonly occurs in younger women. it is associated with human papillomavirus and tends to have multifocal and multicentric involvement. differentiated vin is frequently associated with benign vulvar dermatoses such as lichen sclerosus and lichen simplex ...201020868402
[infection of human papillomavirus 16/18 dna in patients with head and neck squamous cell carcinoma and its relationship with expression of ki-67 and p53 protein].to detect the infection of human papillomavirus (hpv) 16/18 in patients with head and neck squamous cell carcinoma and explore the relationship between hpv infection and expressions of ki-67 and p53 proteins in tumor tissue.201020868604
human papillomavirus-positive basaloid squamous cell carcinomas of the head and neck. 201020868902
cervical cancer working group report.disease burden of cervical cancer in asia was summarized. human papillomavirus 16 is the most oncogenic human papillomavirus type. korea's national cervical cancer screening program targets women aged 30 or over, with coverage of almost 80%. japan has a long history (50 years) of cervical cancer screening, and cytological screening programs have reduced the incidence/mortality of cervical cancer by 70%. but, recent cervical cancer screening coverage is ∼24%. modeling suggested that vaccination o ...201020870919
prevalence of low-risk and high-risk types of human papillomavirus and other risk factors for hpv infection in germany within different age groups in women up to 30 years of age: an epidemiological observational study.human papillomavirus (hpv) infection is frequent in young women and persistent infection may lead to cervical cancer. therefore, vaccination against hpv is recommended for young women in the age group from 12-17 years in germany. however, epidemiological data on the prevalence of hpv types and risk factors for infection for younger women in germany is scarce. to address this, an observational study was performed in germany including 1,692 women aged 10-30 years. after a routine pap smear, cervic ...201020872721
mutational analysis of kinetic partitioning in protein folding and protein-dna binding.kinetic partitioning between competing routes is present in many biological processes. here, we propose a methodology to characterize kinetic partitioning through site-directed mutagenesis and apply it to parallel routes for unfolding of the ti i27 protein and for recognition of its target dna by the human papillomavirus e2 protein. the balance between the two competing reaction routes can be quantified by the partitioning constant k(p). k(p) is easily modulated by point mutations, opening the w ...201020876193
composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with peutz jeghers syndrome.an unusual cervical adenocarcinoma is reported in a 50-year-old woman with a history of peutz jeghers syndrome. the carcinoma contained two morphologically distinct and spatially separate components, one comprising typical well differentiated adenoma malignum and the other a moderately differentiated neoplasm, in keeping with gastric type adenocarcinoma. both components were positive for hik1083 and muc6 and negative for p16, and did not contain human papillomavirus. it is believed that such a c ...201020876329
cervical hpv infection in brazil: systematic review.to assess the prevalence of human papillomavirus (hpv) infection in women in brazil.201020877926
hpv knowledge in mexican college students: implications for intervention programmes.in order to promote new human papillomavirus (hpv) prevention and detection methods effectively in mexico, it is important to understand how much the population knows about the virus. this study aimed to determine the demographic and behavioural factors associated with hpv awareness and knowledge in a population of mexican college students. with a response rate of 77%, data were collected from 1109 college students aged 17-25 years old at the autonomous university of the state of morelos in 2006 ...201020880104
absence of high-risk human papillomavirus (hpv) detection in endocervical adenocarcinoma with gastric morphology and phenotype.a subset of endocervical-type mucinous adenocarcinomas (acs) of the uterine cervix exhibit a gastric phenotype and morphology, as reported in cases of minimal deviation ac in which the presence of human papillomavirus (hpv) has been rarely detected. to investigate the hpv-independent pathway of carcinogenesis in cases of gastric-type ac, we investigated the common high-risk hpv (hr-hpv) status in 52 nonsquamous cell carcinomas, using a pcr-based typing method and immunohistochemistry of p16ink4a ...201020829441
impaired toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer.hiv-1, hepatitis b virus, hepatitis c virus, and human papillomavirus type 16 cause persistent infections that frequently precede cancer development. virions of these viruses are weak inducers of interferon-α and impair toll-like receptor (tlr)9 function. loss of tlr9 responsiveness also occurs in tumors without viral etiology such as breast, ovary, and head and neck carcinomas. recent reports have suggested that viruses and components of the tumor microenviroment interact with regulatory recept ...201020832362
[multifocal epithelial hyperplasia: a familial case].multifocal epithelial hyperplasia (meh), or heck disease, is a disease of the oral mucosa rarely seen in spain. it is caused by the human papillomavirus (hpv), and is mainly associated with types 13 and 32. it appears in childhood (3-18 years) and a higher prevalence is reported in women and certain ethnic groups (american indians and eskimos). it consists of a benign, asymptomatic epithelial proliferation in the form of multiple papules of 3-10mm with a normal oral mucosa colour. the case invol ...201020833119
stopping hpvs dead in their tracts.vaccines are currently available to prevent infection of the genital tract and subsequent disease for some human papillomavirus (hpv) types, and attempts to develop broadly cross-reactive hpv vaccines are progressing. a recently developed murine model of cervicovaginal hpv infection examines the mechanisms by which antibodies prevent infection in vivo.201020833372
in vivo mechanisms of vaccine-induced protection against hpv infection.using a human papillomavirus (hpv) cervicovaginal murine challenge model, we microscopically examined the in vivo mechanisms of l1 virus-like particle (vlp) and l2 vaccine-induced inhibition of infection. in vivo hpv infection requires an initial association with the acellular basement membrane (bm) to induce conformational changes in the virion that permit its association with the keratinocyte cell surface. by passive transfer of immune serum, we determined that anti-l1 antibodies can interfere ...201020833377
a modeling framework for the analysis of hpv incidence and persistence: a semi-parametric approach for clustered binary longitudinal data analysis.human papillomavirus (hpv) infection is a common sexually transmitted disease of growing public health importance, and over 40 genotypes have been identified in genital infections. current hpv cohort studies often follow participants at pre-determined visits, such as every 6 months, and data generated from such epidemiology studies can be described as clustered longitudinal binary data where correlation arises in two ways: the directionless clustering due to the multiple genotypes tested within ...201020839368
long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence.infection with high-risk human papillomavirus (hpv) is the main cause of high-grade cervical intraepithelial neoplasia (cin) and cancer. it has been suggested that information about high-risk hpv type-specific infection might make cervical cancer screening more effective. persistent hpv infection could also be a useful screening marker. we estimated the long-term risk of high-grade cin after one-time detection of high-risk hpv dna and after persistent infection with individual high-risk hpv type ...201020841605
global proficiency study of human papillomavirus genotyping.internationally comparable quality assurance of human papillomavirus (hpv) dna detection and typing methods is essential for evaluation of hpv vaccines and effective monitoring and implementation of hpv vaccination programs. therefore, the world health organization (who) hpv laboratory network (labnet) designed an international proficiency study. following announcement at the who website, the responding laboratories performed hpv typing using one or more of their usual assays on 43 coded samples ...201020844222
prevalence of high-risk human papillomavirus types (hpv-16, hpv-18) and their physical status in primary laryngeal squamous cell carcinoma.recently oncogenetic human papilloma virus(hpv) infection has been suggested to promote laryngeal squamous cell carcinoma(lscc). to determine the prevalence and genotypes of hpv infection in laryngeal cancer specimens, 84 specimens from pathologically confirmed lscc patients were studied for the presence of viral dna and possible virus integration into the cellular genome. hpv genotyping was assayed prior to the integration analysis by using two pcr-based assays, including hpv-16 and-18 e7 type- ...201020845999
in vitro activity of dermaseptin s1 derivatives against genital pathogens.the aim of this study was to evaluate the biological activity of nine dermaseptin-s1 (drs-s1) derivatives (synthesized by solid-phase methods and purified) against different pathogens causing genital infections (trichomonas vaginalis, herpes simplex virus, papillomavirus). the in vitro activity on t. vaginalis was determined by counting the protozoon in a hemocytometer after vital staining with trypan blue; antiviral activity of the compounds was tested on monolayers of vero cells for herpes sim ...201020718719
cervical cancer screening in mediterranean countries: implications for the future.prompted by feedback from the 34th european congress of cytology (ecc), the practice of including a special symposium in the programme was continued in the 35th ecc in lisbon (2009) by arranging a satellite symposium entitled 'cervical cancer screening in the mediterranean countries'. because of the importance to the future of this discipline, it was felt appropriate to summarize the highlights of this symposium here. cervical cancer prevention strategies in the countries participating in the sy ...201020718841
cancers attributable to human papillomavirus infection.although the human papillomavirus (hpv) vaccine was introduced primarily as a cervical cancer prevention vaccine, hpv has a causal role in several types of cancer. this article reviews the epidemiological evidence for the role of hpv in human cancer, and describes australian trends in these cancers. hpv is a necessary cause of cervical cancer. the currently vaccine-preventable subtypes of hpv 16 and 18 are responsible for ~70% of cervical cancer. the introduction of an organised pap smear progra ...201020719211
human papillomavirus vaccine introduction in vietnam: formative research findings.formative research is a useful tool for designing new health interventions. this paper presents key findings from formative research conducted in vietnam to guide human papillomavirus (hpv) vaccine introduction.201020719213
low rates of free human papillomavirus vaccine uptake among young women.to determine uptake of quadrivalent human papillomavirus recombinant vaccine (quadrivalent; gardasil((r)), merck, new jersey, usa) offered under optimal conditions to women 18 to 24 years of age, and to identify predictors of uptake.201020719216
human papillomavirus vaccine acceptability among a national sample of adult women in the usa.in the usa, the human papillomavirus (hpv) vaccine is currently licensed for 9-26-year-old females, but licensure for women over 26 years is being considered. the aim of the current study was to investigate the association of sociodemographic and health-related factors to hpv vaccine acceptability among adult women.201020719219
us physicians' intentions regarding impact of human papillomavirus vaccine on cervical cancer screening.us cervical cancer screening recommendations have not changed since the human papillomavirus (hpv) vaccine introduction in 2006, but epidemiological and cost-effectiveness studies indicate that recommendations will need to change for fully vaccinated women. we evaluated physician intentions regarding hpv vaccine's impact on future screening.201020719225
models of cervical screening in the era of human papillomavirus vaccination.epidemiologic and economic evaluation using simulation modelling can support complex policy decisions, and is an important tool in predicting the future interaction between human papillomavirus vaccination and cervical screening. several categories of screening program evaluation are of interest, including: (1) changes to screening considered over the short term, over which the effects of vaccination should be confined to the youngest age groups (<30 years old); (2) the medium and long-term effe ...201020719228
global reduction of cervical cancer with human papillomavirus vaccines: insights from the hepatitis b virus vaccine experience.worldwide, prophylactic vaccines against two major human cancers are now commercially available: hepatitis b virus (hbv) vaccines (first licensed in 1982) against primary hepatocellular carcinoma and human papillomavirus (hpv) vaccines (first licensed 2006) against cervical cancer. initial implementation strategies for hbv vaccination were not successful in preventing disease in the community: it took 15 years for significant global reduction in the burden of this disease.201020719231
human papillomavirus (hpv) vaccine acceptance and perceived effectiveness, and hpv infection concern among young new zealand university students.two-hundred undergraduate students completed an anonymous questionnaire after viewing a human papillomavirus (hpv) vaccine television commercial. eight-four percent of participants would accept a free hpv vaccine, whereas 47% were unconcerned about future personal hpv infection risk. males were less likely to accept a free hpv vaccine and to be concerned about future personal hpv infection risk. perceived hpv vaccine effectiveness was significantly greater among participants who had previously h ...201020719233
inclusion and exclusion in mid-life lesbians' experiences of the pap test.lesbians are said to feel excluded by sexual health messages that presume heterosexuality, a finding linked to lower levels of papanicolaou (pap) testing. this paper discusses a small, focused qualitative study based in calgary, canada that illuminated mid-life lesbians' experiences and perceptions of pap testing and health. participants indicated that they felt compelled and invited to access pap testing by an inclusive discourse - that of 'mid-life', a period associated with an increased need ...201020721767
prevalence and stability of antibodies to 37 human papillomavirus types--a population-based longitudinal study.information about serostability of cutaneous hpv types over time is very limited. we investigated seroprevalence and serostability of 37 different hpv types over 4½ years in an australian population-based study. sera and data were analyzed for 390 people who had never been diagnosed with scc and had blood collected in 1992, 1993 and 1996. eighty-six percent of participants were seropositive to at least one of the 37 hpv types at baseline. hpv-4 was the type with the highest seroprevalence (41%), ...201020723959
hpv vaccination's second act: promotion, competition, and compulsion.developments regarding human papillomavirus (hpv) vaccines will transform hpv vaccination in the united states while simultaneously raising several new policy and ethical concerns. policymakers, vaccine manufacturers, and the public health community must now respond to the presence of competing vaccines that are similar but distinct, particularly with respect to genital wart prevention and the benefits of vaccinating males. this work arises in the shadow of the contentious introduction of the hp ...201020724671
impact of vaccinating boys and men against hpv in the united states.we assessed the public health impact and value of vaccinating boys and men with the quadrivalent hpv vaccine in the united states. we used mathematical population models, accounting for both the direct and indirect protective effects of vaccination. inputs for the models were obtained from public data sources, published literature, and analyses of clinical trial data. compared with a program of vaccinating girls and women only, including boys and men 9-26 years of age would further decrease the ...201020713101
topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.anal intraepithelial neoplasia (ain), a human papillomavirus (hpv)-induced potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (hiv)-positive men who have sex with men (msm). so far, only a few prospective studies have been performed on the topical treatment of ain, especially at the intra-anal location.201020716208
assessing the relationship between hiv infection and cervical cancer in côte d'ivoire: a case-control study.the association between hiv infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (hpv) infection or uncontrolled confounding. we conducted a case-control study in a west african population to assess the relationship between hiv infection and invasive cervical cancer, taking into account hpv infection and other potential risk factors for cervical cancer.201020716343
prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in italy.the aim of this multicentric study was to identify human papillomavirus (hpv) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (cin2/3) in italy.201020826836
human papillomavirus and tar hypothesis for squamous cell cervical cancer. 201020826942
prevalence and genotype distribution of cervical human papillomavirus infection in macao.population-specific epidemiological data on human papillomavirus (hpv) infection are essential for formulating strategies to prevent cervical cancer. the age-specific prevalence of hpv infection was determined among 1,600 women enrolled for cervical screening in macao. a u-shaped age-specific prevalence curve with a first peak (prevalence rate, 10%) at 20-25 years and a second peak (13%) at 51-55 years was observed. co-infections with multiple types were detected in 32.5% of hpv-positive subject ...201020827770
prevalence of human papillomavirus (hpv) in chinese patients with colorectal cancer.abstract aim: the prevalence of human papillomavirus (hpv) was determined in chinese patients with colorectal cancer (crc). the study also aimed to determine whether hpv dna peripheral blood assay can be used to diagnose hpv-related crc. method: tumor tissue, non-cancerous colorectal tissue and whole blood samples were obtained from 96 crc patients. in addition, 32 colorectal tissue samples were harvested from patients without crc and 48 whole blood samples were collected from healthy blood dono ...201020528894
hpv16 e2 is an immediate early marker of viral infection, preceding e7 expression in precursor structures of cervical carcinoma.the viral e2 gene product plays a crucial role in the human papillomavirus (hpv) vegetative cycle by regulating both transcription and replication of the viral genome. e2 is a transcriptional repressor of the e6 and e7 viral oncogenes for hpv types 16 and 18, which are involved in cervical cancers. using new polyclonal antibodies against the hpv16 e2 protein, we showed that e2 is expressed at various precursor stages of cervical carcinoma by immunohistochemistry on paraffin-embedded clinical sam ...201020530671
e6-associated protein is required for human papillomavirus type 16 e6 to cause cervical cancer in mice.high-risk human papillomaviruses (hpv) cause certain anogenital and head and neck cancers. e6, one of three potent hpv oncogenes that contribute to the development of these malignancies, is a multifunctional protein with many biochemical activities. among these activities are its ability to bind and inactivate the cellular tumor suppressor p53, induce expression of telomerase, and bind to various other proteins, including bak, e6bp1, and e6tp1, and proteins that contain pdz domains, such as hscr ...201020530688
who should get the hpv vaccine? usage expands amid debate. 201020530765
htert promoter activity and cpg methylation in hpv-induced carcinogenesis.activation of telomerase resulting from deregulated htert expression is a key event during high-risk human papillomavirus (hrhpv)-induced cervical carcinogenesis. in the present study we examined htert promoter activity and its relation to dna methylation as one of the potential mechanisms underlying deregulated htert transcription in hrhpv-transformed cells.201020534141
perianal bowen disease in a child with human immunodeficiency virus.individuals infected with the human immunodeficiency virus (hiv) are at increased risk for human papillomavirus (hpv)-related cancers of the anogenital region. a majority of these cancers have been reported in adult patients; few reports are available regarding anogenital hpv-associated carcinomas developing in children. we report a case of perianal bowen disease in an hiv-positive child. an 8-year-old hiv-positive boy with a history of perianal verrucous lesions presented to a clinic in lesotho ...201020537068
relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer.this study examines the prognostic significance of epidermal growth factor receptor (egfr) expression in relation to human papillomavirus (hpv) status in oropharyngeal squamous cell carcinoma (scc).201020537890
acr appropriateness criteria: local-regional therapy for resectable oropharyngeal squamous cell carcinomas.the optimal management of resectable oropharyngeal squamous cell carcinomas is controversial with many treatment options, both surgical and nonsurgical approaches, supported by published experiences with no randomized trials comparing commonly accepted treatments. the treatment decisions are further complicated by the need for local-regional disease control and competing goals to preserve salivary and swallow function. treatment decisions may also be affected by tumor and patient related factors ...201020541056
carrageenan as an adjuvant to enhance peptide-based vaccine potency.new innovative therapies are urgently required in order to combat the high mortality and morbidity associated with advanced cancers. antigen-specific cancer immunotherapy using peptide-based vaccination has emerged as an attractive approach for the control of cancers due to its simplicity and easy preparation. however, such an approach requires the employment of suitable adjuvants. in the current study, we explored the employment of a sulfated polysaccharide compound from red algae, carrageenan ...201020541583
the isg15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of isg15.isg15 is an interferon-induced and antiviral ubiquitin-like protein (ubl). herc5, the major e3 enzyme for isg15, mediates the isgylation of more than 300 proteins in interferon-stimulated cells. in addressing this broad substrate selectivity of herc5, we found that: (1) the range of substrates extends even further and includes many exogenously expressed foreign proteins, (2) isg15 conjugation is restricted to newly synthesized pools of proteins, and (3) herc5 is physically associated with polyri ...201020542004
external quality assessment for molecular detection of human papillomaviruses.the united kingdom national external quality assessment service (uk neqas) distributes clinically relevant and educational specimens for external quality assessment (eqa).201020542463
male circumcision to reduce sexual transmission of hiv.three large trials among african heterosexual men in the last decade have confirmed that male circumcision reduces hiv acquisition. this review summarizes recent data regarding circumcision performed primarily to reduce hiv in high-prevalence settings.201020543611
p16(ink4a) is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia.the primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (icc) assay for p16(ink4a) to high-risk (hr) human papillomavirus (hpv) detection by polymerase chain reaction (pcr) as diagnostic adjuncts for cytology specimens from colposcopy patients.201020544710
recurrent respiratory papillomatosis with malignant transformation. 201020546542
human papillomavirus vaccination of males: attitudes and perceptions of physicians who vaccinate females.we assessed u.s. physicians' attitudes and perceptions regarding potential human papillomavirus (hpv) vaccination of males.201020547286
success or failure of vaccination for hpv16-positive vulvar lesions correlates with kinetics and phenotype of induced t-cell responses.one half of a group of 20 patients with human papillomavirus type 16 (hpv16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (cr) after therapeutic vaccination with hpv16 e6/e7 synthetic long peptides. patients with relatively larger lesions generally did not display a cr. to investigate immune correlates of treatment failure, patients were grouped according to median lesion size at study entry, and hpv16-specific immunity was analyzed at different time points by ...201020547850
cervical cancer screening with both human papillomavirus and papanicolaou testing vs papanicolaou testing alone: what screening intervals are physicians recommending?guidelines recommend screening for cervical cancer among women 30 years or older 3 years after a normal papanicolaou test (hereinafter referred to as pap test) result or a combined normal screening result (normal pap/negative human papillomavirus [hpv] test results). we assessed reported recommendations by us primary care physicians (pcps) on screening intervals that incorporate hpv cotesting compared with pap testing alone.201020548011
the natural history of human papillomavirus infections of the mucosal epithelia.human papillomaviruses (hpvs), members of a very large family of small dna viruses, cause both benign papillomas and malignant tumors. while most research on these viruses over the past 30 years has focused on their oncogenic properties in the genital tract, they also play an important role in diseases of the upper aerodigestive tract. rapidly accelerating advances in knowledge have increased our understanding of the biology of these viruses and this knowledge, in turn, is being applied to new a ...201020553526
interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses.persistent infection by a subgroup of so-called high-risk human papillomaviruses (hpvs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. infection of squamous epithelial tissues in the head and neck region by these same high-risk hpvs is also associated with a subset of cancers. despite the general conservation of genetic structure amongst all hpv types, infectio ...201020553529
high-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays.we have developed microarrays with all eight proteins encoded by 13 different human papillomavirus types associated with anogenital cancer (hpv-16, -18, -31, -33, -35, -45, and -53), genital warts (hpv-6 and -11), or skin lesions (hpv-1, -2, -4, and -5). we analyzed the seroprevalence of antibodies in 546 patients, which had either cervical carcinomas, or precursor lesions, or which were asymptomatic. all patient groups contained sera ranging from high reactivity against multiple hpv proteins to ...201020554302
mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of dna vaccination.mucosal immunization may be important for protection against pathogens whose transmission and pathogenesis target the mucosal tissue. the capsid proteins of human papillomavirus (hpv) confer tropism for the basal epithelium and can encapsidate dna during self-assembly to form pseudovirions (psvs). therefore, we produced mucosal vaccine vectors by hpv psv encapsidation of dna plasmids expressing an experimental antigen derived from the m and m2 proteins of respiratory syncytial virus (rsv). intra ...201020555315
cigarette smoke condensate induces nuclear factor kappa-b activity and proangiogenic growth factors in aerodigestive cells.aerodigestive cancer risk of both lung and head and neck cancers has been linked to the genotoxic effects of tobacco use. these effects include upregulation of nuclear factor kappa-b (nfkappab) and its downstream products associated with both lung and head and neck cancer malignant progression.201020564670
[progress in the world and challenges in japan on hpv vaccination for cervical cancer prevention].for cervical cancer prevention, cervarix(hpv-16/18)was approvedin japan andvaccination programs against hpv-16/18 were startedin december, 2009. this vaccine is almost 100% effective in preventing high-grade precancer associated with the hpv types; it is safe and well tolerated. in japan, universal vaccination of females between 11 and 14 years is recommended. we all look forward to eradicating cervical cancer in the not too distant future.201020567096
age-specific hpv seroprevalence among young females in the netherlands.to obtain insight into the age-specific seroprevalence for human papillomavirus (hpv) 6, 11, 16 and 18 among females before introduction of hpv vaccination in the netherlands.201020519252
an infant presenting with a voluminous exophytic perineal mass. 201020524229
p53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in korean women.the aims of this study were to evaluate the genotype frequencies of p53 codon 72 and p21 codon 31 in cervical adenocarcinoma patients and controls, and the association between the specific genotype or genotype combination of these polymorphisms and the risk of cervical adenocarcinoma in korean women. genotyping was performed using dna from cervical biopsy specimens collected from 53 patients with cervical adenocarcinoma, of whom 34 were hpv 16 or 18 positive, and from the cervical exfoliated cel ...201020524403
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