Publications

in-vivo effectiveness of adapalene 0.1%/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant propionibacterium acnes.	background: a gel combination treatment containing a retinoid (adapalene 0.1%) and an antimicrobial (benzoyl peroxide 2.5%) has been shown to be an effective treatment for acne vulgaris, addressing three of the four pathogenic factors (hyperkeratinization, propionibacterium acnes proliferation, inflammation) without contributing to the incidence of propionibacterium acnes antibiotic resistance as neither the retinoid nor benzoyl peroxide creates selective pressure for resistance. objective: to e ...	2011	21607190
efficacy of preoperative home use of 2% chlorhexidine gluconate cloth before shoulder surgery.	hypothesis: deep infection after shoulder surgery is a rare but devastating problem. this study tested the hypothesis that the home application of a 2% chlorhexidine gluconate cloth before shoulder surgery would be more efficacious than a standard shower of soap and water at decreasing the preoperative cutaneous levels of pathogenic bacteria on the shoulder. materials and methods: this randomized, prospective study evaluated 100 consecutive patients undergoing shoulder surgery. patients were ran ...	2011	21612945
a descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery.	background surgical site infections (ssis) after dermatologic surgery cause pain, prolong healing, result in unaesthetic complications, and lead to excessive use of antibiotics. the pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors. objective to investigate bacterial dynamics at dermatosurgical sites at different time intervals and assess the correlation with postoperative outcomes and to examine different endo- and exogenous fact ...	2011	21615603
new insights into physiology and metabolism of propionibacterium freudenreichii.	dairy propionibacteria are actinobacteria, mainly isolated from dairy environments. propionibacterium freudenreichii has been used for a long time as a ripening culture in swiss-type cheese manufacture, and is more and more considered for its potent probiotic effects. this review summarises the knowledge on the main p. freudenreichii pathways and the main features explaining its hardiness, and focuses on recent advances concerning its applications as a cheese ripening agent and as a probiotic fo ...	2011	21620505
nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice.	microbial components stimulate innate immunity via toll-like receptors (tlrs), nucleotide-binding oligomerization domain (nod)-like receptors (nlrs), and/or il-1. we recently reported that in mice, escherichia coli lipopolysaccharide (lps, tlr4-ligand) promotes allergic responses to nickel (ni) at both the sensitization and elicitation steps. here, we examined in mice the effects of administering other microbial or inflammatory materials at the ni-sensitization step. a mixture of 1mm nicl(2) and ...	2011	21621645
passive immunoprotection targeting a secreted camp factor of propionibacterium acnes as a novel immunotherapeutic for acne vulgaris.	propionibacterium acnes (p. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive effect against p. acnes, the lack of therapeutic activities and incapability of neutralizing secretory virulence factors motivate us to generate novel immunotherapeutics. in this study, we develop an immunotherapeutic antibody to secretory christie-atkins-munch-pete ...	2011	21354482
treating acne with antibiotic-resistant bacterial colonization.	introduction: acne is a chronic skin disorder of the pilosebaceous unit; it has a multifactorial pathogenesis. propionibacterium acnes within the follicle is considered to be a triggering factor of inflammation in acne. antibiotics have been the primary treatment against p. acnes for more than 40 years. however, a gradual increase in the prevalence of antibiotic-resistant strains of p. acnes has been observed. areas covered: this review discusses the pathophysiology of antibiotic-resistant acne ...	2011	21355786
impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions.	abstract. rafferty b, jönsson d, kalachikov s, demmer rt, nowygrod r, elkind msv, bush jr h, kozarov e. (columbia university medical center, new york, ny; and weill cornell medical college, new york, ny; usa) impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. j intern med 2011; 270: 273-280. objective. epidemiological evidence suggests that infections may contribute to atherogenesis. however, with the exception of chlamydophila pneumoniae, cultivable b ...	2011	21366733
clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies.	the risk of surgical site infection (ssi) after craniotomies or craniectomies in patients in whom contaminated bone flaps have been reimplanted has not been determined. the objectives of this study were to identify the prevalence of bone flaps with positive cultures--especially those contaminated with propionibacterium acnes--to assess the risk of ssi after reimplanting (either during the initial operation or subsequently) bone flaps with positive cultures, and to identify risk factors for ssi f ...	2011	21375380
effect of propionibacterium acnes-containing immunostimulant on interferon-gamma (ifn+¦) production in the neonatal foal.	production of the th1 cytokine interferon gamma (ifn+¦) is associated with resistance to intracellular pathogens, including rhodococcus equi. while neonatal foals are initially deficient in ifn+¦ production, expression of this cytokine increases throughout their first year of life. this is presumably the result of stimulation by environmental antigens including pathogen associated molecular patterns (pamps) signaling through toll-like receptors (tlr). this increased expression of ifn+¦ is likewi ...	2011	21382640
oral antibiotic therapy for acne vulgaris: pharmacokinetic and pharmacodynamic perspectives.	objective: to review data on pharmacokinetic factors that influence the absorption and tissue distribution for individual antibiotic agents to better inform clinicians on rational dosing considerations of oral antibiotics for the treatment of acne vulgaris. the focus is placed on the most commonly prescribed oral antibiotics for acne vulgaris, the tetracyclines. dose-response is also reviewed. design and methods: this review describes factors affecting the absorption, distribution, and target ti ...	2011	21386956
probiotic lactobacillus rhamnosus downregulates fcer1 and hrh4 expression in human mast cells.	to investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.	2011	21390145
three cases of pr3-anca positive subacute endocarditis caused by attenuated bacteria (propionibacterium, gemella, and bartonella) complicated with kidney injury.	subacute bacterial endocarditis (sbe) associated with antiproteinase-3 antineutrophil cytoplasmic antibodies (pr3-anca) has previously been reported in 10 cases of streptococcus viridans and in 1 case of escherichia faecalis infection. most of these patients had hypocomplementemia and were positive for several autoantibodies. the infections in most of these patients showed good responses to antibiotic treatment. we report three patients with anca-positive sbe, which was induced by attenuated slo ...	2011	21400245
safety evaluation of propionibacterium freudenreichii et-3 culture.	propionibacterium freudenreichii et-3 culture, a cell-free product of whey fermentation using p. freudenreichii et-3 (7025), has been shown to promote the growth of bifidobacteria through the action of 1,4-dihydroxy-2-naphthoic acid (dhna), and therefore, has potential use in the food and supplement industries. although currently used as a food ingredient in japan, the safety of this novel ingredient has not been previously evaluated through traditional toxicity testing. therefore, here we repor ...	2011	21406207
recent trends in specular light reflectance beyond clinical fluorescence diagnosis.	under specific light illumination, particularly ultraviolet (uv) and near-uv light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. these properties offer diagnostic clues and disclose some peculiar functions of the skin. a series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in propionibacterium spp show fluorescence. this latter ...	2011	21411414
a probiotic mixture including galactooligosaccharides decreases fecal ß-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention.	a high serum concentration of enterolactone, an enterolignan produced by colonic microbiota from precursors in cereals, vegetables, and fruits, is associated with reduced risk of acute coronary events. probiotics and prebiotics modify colonic metabolism and may affect the serum enterolactone concentration. the effects of a probiotic mixture alone and with galactooligosaccharides (gos) on serum enterolactone concentration and fecal metabolism were investigated in 18 healthy men. participants rece ...	2011	21411613
indole-3-acetic acid: a potential new photosensitizer for photodynamic therapy of acne vulgaris.	ala (5-aminolevulinic acid) photodynamic therapy (pdt) is a new treatment option for acne. however, it needs a relatively long incubation period and adverse effects are common. indole-3-acetic acid (iaa) is not toxic by itself but produces free radicals with ultraviolet b. in this study we examined the potential of iaa as a photosensitizer for acne treatment.	2011	21412803
augmentation of gene expression and production of promatrix metalloproteinase 2 by propionibacterium acnes-derived factors in hamster sebocytes and dermal fibroblasts: a possible mechanism for acne scarring.	aberrant extracellular matrix (ecm) remodeling in sebaceous glands and pilosebaceous units in the skin is associated with scar formation under acne conditions. to investigate the involvement of propionibacterium acnes (p. acnes), a gram-positive anaerobic microbial species, in ecm remodeling in sebaceous glands and pilosebaceous units, we examined the effects of p. acnes culture media, formalin-fixed p. acnes, and peptidoglycan (pgn) from gram-positive bacteria walls on the production of promatr ...	2011	21415544
green and economical production of propionic acid by propionibacterium freudenreichii cctcc m207015 in plant fibrous-bed bioreactor.	propionic acid production by propionibacterium freudenreichii from molasses and waste propionibacterium cells was studied in plant fibrous-bed bioreactor (pfb). with non-treated molasses as carbon source, 12.69 ± 0.40 g l(-1) of propionic acid was attained at 120 h in free-cell fermentation, whereas the pfb fermentation yielded 41.22 ± 2.06 g l(-1) at 120 h and faster cells growth was observed. in order to optimize the fermentation outcomes, fed-batch fermentation was performed with hydrolyzed m ...	2011	21421303
preparation, characterization, and in vitro antimicrobial assessment of nanocarrier based formulation of nadifloxacin for acne treatment.	the objective of the present study was to develop a nanocarrier based formulation of nadifloxacin and to investigate its in vitro antimicrobial effect against propionibacterium acnes. nanocarrier based microemulsion formulations were prepared by aqueous titration method, using oleic acid as oil phase, tween-80 as surfactant and ethanol as co-surfactant in different ratios. this procedure yielded monodisperse microemulsions exhibiting a mean droplet size in the range of 95-560 nm. this range of p ...	2011	21434572
isolation and characterization of tetrachloroethylene- and cis-1,2-dichloroethylene-dechlorinating propionibacteria.	two rapidly growing propionibacteria that could reductively dechlorinate tetrachloroethylene (pce) and cis-1,2-dichloroethylene (cis-dce) to ethylene were isolated from environmental sediments. metabolic characterization and partial sequence analysis of their 16s rrna genes showed that the new isolates, designated as strains propionibacterium sp. hk-1 and propionibacterium sp. hk-3, did not match any known pce- or cis-dce-degrading bacteria. both strains dechlorinated relatively high concentrati ...	2011	21437617
[bacterial mixed infection in women with chronic recurrent cystitis].	to study microbial repertoire of urine in healthy women and patients with chronic recurrent cystitis (crc) including facultative anaerobic (fa) and non-clostridial anaerobic (nca) bacteria. materials and methods. triple bacteriological study of urine was performed in three groups of women: group i--22 healthy virgin women aged 18- 25 years, group ii--24 women aged 18 - 25 years with regular sexual contacts, group iii--72 women aged 20 - 60 years with crc, before antibacterial therapy. bacteriolo ...	2011	21446162
quantification of propionibacterium acidipropionici p169 bacteria in environmental samples by use of strain-specific primers derived by suppressive subtractive hybridization.	a quantitative pcr (qpcr) assay targeting a gene identified by suppressive subtractive hybridization (ssh) was developed to detect propionibacterium acidipropionici p169, with a threshold of 10(4) cfu/u of dairy feed or rumen fluid. the report is the first using a molecular marker generated by ssh to quantify a bacterial strain in environmental samples.	2011	21460112
deep brain stimulation hardware-related infections: a report of 12 cases and review of the literature.	in this monocentric study, the median delay between deep brain stimulation implantation and infection was 28 days (range, 8-820). infections limited to generator (n = 4) required partial hardware removal, whereas infections involving frontal or retroauricular sites (n = 7) required total removal. surgical samples yielded staphylococcus aureus (n = 6), staphylococcus epidermidis (n = 2), propionibacterium acnes, and micrococcus species.	2011	21460317
anti-inflammatory properties of a new undecyl-rhamnoside (aprc11) against p. acnes.	acne vulgaris is a skin disease affecting pilosebaceous glands in which propionibacterium acnes (p. acnes) induced inflammation plays a central role. in order to develop new therapies against the inflammatory events, we evaluated the modulating effect of a new undecyl-rhamnoside, aprc11, on different markers of the inflammation. for this purpose, normal human keratinocytes taken from five healthy donors were pre-incubated for 24 h with aprc11 or zinc gluconate (zn) which was used as reference mo ...	2011	21461892
infection after shoulder surgery.	infection after shoulder surgery is rare but potentially devastating. normal skin flora, including staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes, are the most commonly isolated pathogens. perioperative measures to prevent infection are of paramount importance, and clinical acumen is necessary for diagnosis. superficial infections may be managed with local wound measures and antibiotics; deep infections require surgical débridement in combination with antibiotic t ...	2011	21464214
galvanic zinc-copper microparticles produce electrical stimulation that reduces the inflammatory and immune responses in skin.	the human body has its own innate electrical system that regulates the body's functions via communications among organs through the well-known neural system. while the effect of low-level electrical stimulation on wound repair has been reported, few studies have examined the effect of electric potential on non-wounded, intact skin. a galvanic couple comprised of elemental zinc and copper was used to determine the effects of low-level electrical stimulation on intact skin physiology using a derma ...	2011	21465312
isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne.	a clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area. recently, the protein neutrophil gelatinase-associated lipocalin (ngal) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes.	2011	21466536
propionibacterium acnes osteomyelitis occurring 23 years after craniotomy: case report and review of literature.	background and importance:: propionibacterium acnes is an uncommon pathogen in delayed surgical site infection, and its indolent course can complicate diagnosis and treatment. we report the longest delay between neurosurgery and p. acnes infection reported. clinical presentation:: asymptomatic postoperative p. acnes osteomyelitis and tumor recurrence occurring 23 years after initial craniotomy. initial presentation was of tumor recurrence only, without signs or symptoms of infection. calvarial o ...	2011	21471838
a case of brain abscess caused by propionibacterium acnes 13 months after neurosurgery and confirmed by 16s rrna gene sequencing.	propionibacterium acnes is a gram-positive anaerobic bacillus and a normal inhabitant of the skin. although it is often considered a contaminant of blood cultures, it can occasionally cause serious infections, including postoperative central nervous system infections. here, we report the case of a 70-yr-old man who developed a large cerebral abscess caused by p. acnes 13 months after neurosurgery. immediate gram staining of the pus from his brain revealed the presence of gram-positive coccobacil ...	2011	21474989
concomitant presentation of a glioblastoma multiforme with superimposed abscess.	the coexistence of a primary brain tumor such as high-grade glioma and superimposed abscess is a rare entity and can present a diagnostic and therapeutic challenge. the concomitant abscess may not be recognized until surgery, and the overall course of treatment may require adjustment in the presence of a coinciding infection. in the present report we evaluate the diagnosis and treatment of a glioblastoma multiforme with an intratumoral abscess.	2011	21492676
a microbial aetiology of acne-what is the evidence?	a microbial aetiology of acne has been suggested since the beginning of the last century. there is considerable evidence, circumstantial at best, which suggests that micro-organisms, particularly propionibacterium acnes, are important in the pathogenesis of acne vulgaris. however, it is still unclear whether propionibacterium acnes is actually a causal agent in the development of non-inflamed or inflamed acne lesions. based on a review of the microbiological data on normal and acne affected skin ...	2011	21495996
microbial communities of the upper respiratory tract and otitis media in children.	streptococcus pneumoniae asymptomatically colonizes the upper respiratory tract of children and is a frequent cause of otitis media. patterns of microbial colonization likely influence s. pneumoniae colonization and otitis media susceptibility. this study compared microbial communities in children with and without otitis media. nasal swabs and clinical and demographic data were collected in a cross-sectional study of philadelphia, pa, children (6 to 78 months) (n=108) during the 2008-2009 winter ...	2011	21285435
phenelfamycins g and h, new elfamycin-type antibiotics produced by streptomyces albospinus acta 3619.	phenelfamycins g and h are new members of the family of elfamycin antibiotics with the basic structure of phenelfamycins e and f, respectively, which are also well known as ganefromycins a and ß. phenelfamycins g and h differ from phenelfamycins e and f by an additional hydroxy group at position c-30, which is not described so far for any of the elfamycin-type antibiotics. the actinomycete strain that produced phenelfamycins g and h was identified to be streptomyces albospinus based on its 16s r ...	2011	21285962
large thoracomyoplasty and negative pressure therapy for late postpneumonectomy empyema with a retrosternal abscess: a modern version of the clagett procedure.	a 63-year-old male with a history of cancer, and who had undergone a left pneumonectomy seven years before, presented with deterioration in his general status and recent dyspnea [stage iii (new york heart association) nyha]. imaging revealed a contralateral mediastinal shift and cardiac compression caused by pneumonectomy cavity enlargement and a retrosternal liquid mass. late empyema associated with a retrosternal abscess caused by propionibacterium acnes was diagnosed after thoracoscopy and an ...	2011	21303873
late capsular block syndrome associated with propionibacterium acnes.		2011	21320976
clinical significance of propionibacterium acnes recovered from blood cultures: analysis of 524 episodes.	of 522 patients with propionibacterium acnes bacteremia (pab), 18 (3.5%) had clinically significant pab. of these 18 patients, 10 (55.6%) had hospital-acquired bacteremia and 6 (33.3%) had undergone invasive procedures before development of pab. one patient with a ventricular septal defect presented with infective endocarditis. after the exclusion of 1 patient whose outcome was not available, the overall mortality rate was 5.9% (1/17).	2011	21325550
bacterial screening by flow cytometry offers potential for extension of platelet storage: results of 14 months of active surveillance.	bacterial contamination is currently the major infectious hazard of platelet transfusion in developed countries. it has been demonstrated that a significant transfusion risk remains, in particular with older platelet concentrates (pcs). in 2009, the shelf life of pcs was therefore reduced in germany to 4 days after the day of production according to vote 38. the aim of the present study was the application and implementation of a recently developed flow cytometry-based rapid screening method (ba ...	2011	21272103
blockade of th1 chemokine receptors ameliorates pulmonary granulomatosis in mice.	sarcoidosis is a granulomatous disease of unknown aetiology. we identified immunological targets for the treatment of pulmonary granulomatosis using a murine model generated with propionibacterium acnes. sensitisation and challenge using heat-killed p. acnes and dendritic cells (dcs) were performed to produce pulmonary granulomatosis in c57bl/6 mice. immunological analyses using elisa as well as cdna microarray analysis were used to search for cytokines or chemokines associated with the formatio ...	2011	21273392
fluorescence in situ hybridization for detection of classical propionibacteria with specific 16s rrna-targeted probes and its application to enumeration in gruyère cheese.	the classical or dairy propionibacteria have well-documented industrial applications and have been proposed for probiotic applications. given their industrial importance it is necessary to employ fast and reliable techniques to monitor the growth during products elaboration, industrial fermentations or the intestinal transit. therefore, the aim of this investigation was to design oligonucleotide probes targeting the 16s rrna of dairy propionibacteria and optimise the fluorescence in situ hybridi ...	2011	21276635
comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study.	the purpose of this clinical study was to compare the antimicrobial effects of 2.5% sodium hypochlorite (naocl) and 0.12% chlorhexidine digluconate (chx) when used as irrigants during treatment of teeth with apical periodontitis.	2011	21238793
propionobacter acnes infection as an occult cause of postoperative shoulder pain: a case series.	infections after shoulder surgery are potentially devastating complications. propionibacterium acnes is recognized as a causal agent in shoulder infections. the clinical presentation is usually insidious and nonspecific, but a p. acnes infection could be an occult cause of postoperative shoulder pain.	2011	21240577
interactions between various microbes and ginseng botanicals.	three kinds of interactions occur between ginseng botanicals and microorganisms: a) spoilage of the botanical by various fungi (e.g., aspergillus, penicillium, alternaria, and eurotium species) and bacteria; b) transformation of ginsenosides into more bioactive forms by bacteria such as intrasporangium sp. gs603, microbacterium sp. gs514, caulobacter leidyia, bifidobacterium sp. int57, bifidobacterium sp. sj32, fusobacterium sp. and bacteroides sp., and moulds (e.g., aspergillus niger, fusarium ...	2011	21254831
propionibacterium acnes vaccination induces regulatory t cells and th1 immune responses and improves mouse atopic dermatitis.	atopic dermatitis (ad) is a chronic disease characterized by a polarized th2 immune response. propionibacterium acnes (p. acnes) has been shown to elicit strong th1 immune responses. we hypothesized that the host immune response to p. acnes will prevent the development of ad. to demonstrate this hypothesis, we investigated the effect of p. acnes vaccination on ad that occurs in keratin 14/driven caspase-1 transgenic mouse. vaccination with low dose of p. acnes successfully prevented clinical man ...	2011	21255097
new approaches in light/laser therapies and photodynamic treatment of acne.	acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. the aim of the paper was to revisit adjunctive physical treatments of acne, including light/laser treatments and photodynamic therapy. this review summarizes findings about such treatment modalities with particular emphasis on efficacy and safety. a number of laser/light-based modalities have been developed to meet the increasing demand for new acne treatments. the current ...	2011	21269242
efficacy of an anaerobic swab transport system to maintain aerobic and anaerobic microorganism viability after storage at -80 degrees c.	an amies agar gel swab transport system was evaluated for its ability to maintain bacterial viability and relative quantity after freezing at -80°c. nine american type culture collection (atcc) bacterial strains were used: 3 anaerobic strains (propionibacterium acnes, peptostreptococcus anaerobius, and clostridium sporogenes) and 6 facultative or strict aerobic bacterial strains (stenotrophomonas maltophilia, escherichia coli ([atcc 25922 and atcc 11775], salmonella enterica subsp. enterica sero ...	2011	21217035
the potential use of echinacea in acne: control of propionibacterium acnes growth and inflammation.	acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium propionibacterium acnes. the possibility was investigated that a standardized preparation of echinacea purpurea (echinaforce®), with known antiviral, antiinflammatory and antibacterial properties, might provide a useful alternative treatment in the control of the disease. the herbal extract readily killed a standard laboratory strain of the bacterium and several clinical isolates. in cell culture mode ...	2011	20830697
[antibacterial activity against 224 clinical bacterial strains of jca 250 and jca 251 compounds containing essential oils provided from aroma technologies research].	it was to determine the antibacterial spectrum of jca 250 and jca 251, two naturally occurring compounds from aroma technologies research, on a bacterial population isolated from clinical infections.	2011	20832194
classification of swiss cheese starter and adjunct cultures using fourier transform infrared microspectroscopy.	the acceptability of swiss cheese largely depends on the flavor profile, and strain variations of cheese cultures will affect the final quality. conventional biochemical methods to identify the cultures at the strain level are time-consuming and expensive, and require skilled labor. our objective was to develop rapid classification methods of starter cultures at the strain level by using a combination of hydrophobic grid membrane filters and fourier transform infrared (ftir) spectroscopy. forty- ...	2011	21854910
Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products.	Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Aims To provide dermato ...	2011	22151944
Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial.	Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acn ...	2011	22144763
comparative photodynamic evaluation of new phenothiazinium derivatives against propionibacterium acnes(†).	the screening of recently patented derivatives of the standard phenothiazinium agents methylene blue and toluidine blue was carried out against propionibacterium acnes, the main bacterium associated with acne vulgaris. comparative tests were made using the topical agent benzoyl peroxide (bpo) and standard tetracyclines. each of the photosensitizers employed, including the lead compounds, was photobactericidal at lower concentrations than bpo, and produced a much more rapid kill than the tetracyc ...	2011	22043962
Propionibacterium acnes: infection beyond the skin.	Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. ...	2011	22114965
Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes.	Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two MLST schemes were reported, one based on ...	2011	22205788
butyric acid- and dimethyl disulfide-assimilating microorganisms in a biofilter treating air emissions from a livestock facility.	biofiltration has proven an efficient tool for the elimination of volatile organic compounds (vocs) and ammonia from livestock facilities, thereby reducing nuisance odors and ammonia emissions to the local environment. the active microbial communities comprising these filter biofilms have not been well characterized. in this study, a trickle biofilter treating air from a pig facility was investigated and proved efficient in removing carboxylic acids (>70% reduction), mainly attributed to the pri ...	2011	22003018
intratumoral injection of propionibacterium acnes suppresses malignant melanoma by enhancing th1 immune responses.	malignant melanoma (mm) is an aggressive cutaneous malignancy associated with poor prognosis; many putatively therapeutic agents have been administered, but with mostly unsuccessful results. propionibacterium acnes (p. acnes) is an aerotolerant anaerobic gram-positive bacteria that causes acne and inflammation. after being engulfed and processed by phagocytes, p. acnes induces a strong th1-type cytokine immune response by producing cytokines such as il-12, ifn-γ and tnf-α. the characteristic th2 ...	2011	22216160
factors affecting microbial contamination rate of cord blood collected for transplantation.	background: collection and processing of cord blood (cb) is associated with significant risk of microbial contamination and hence relevant standards mandate microbial screening of the final product. this study aimed to determine the contamination rate and associated risk factors during 14 years of banking at the sydney cord blood bank. study design and methods: cb was collected and processed using a closed system and tested for contamination using blood culture bottles (bact/alert, biomérieux) i ...	2011	22211719
a temporal -omic study of propionibacterium freudenreichii cirm-bia1 adaptation strategies in conditions mimicking cheese ripening in the cold.	propionibacterium freudenreichii is used as a ripening culture in swiss cheese manufacture. it grows when cheeses are ripened in a warm room (about 24°c). cheeses with an acceptable eye formation level are transferred to a cold room (about 4°c), inducing a marked slowdown of propionic fermentation, but p. freudenreichii remains active in the cold. to investigate the p. freudenreichii strategies of adaptation and survival in the cold, we performed the first global gene expression profile for this ...	2012	22253706
the role of rifampin against propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model.	propionibacterium acnes is an important cause of orthopedic implant-associated infections, for which the optimal treatment has not yet been determined. we investigated the activity of rifampin, alone and in combination, against planktonic and biofilm p. acnes in vitro and in a foreign-body infection model. the mic and the minimal bactericidal concentration (mbc) were 0.007 and 4 μg/ml for rifampin, 1 and 4 μg/ml for daptomycin, 1 and 8 μg/ml for vancomycin, 1 and 2 μg/ml for levofloxacin, 0.03 a ...	2012	22252806
reply: "follicular spicules associated with propionibacterium acnes with response to erythromycin": lack of evidence for the species?		2012	22225404
molecular detection of in-vivo microbial contamination of metallic orthodontic brackets by checkerboard dna-dna hybridization.	knowing the microbiota that colonizes orthodontic appliances is important for planning strategies and implementing specific preventive measures during treatment. the purpose of this clinical trial was to evaluate in vivo the contamination of metallic orthodontic brackets with 40 dna probes for different bacterial species by using the checkerboard dna-dna hybridization (cddh) technique.	2012	22196182
Vitamin B(12) production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii: Optimization of medium composition through statistical experimental designs.	A two-step statistical experimental design was employed to optimize the medium for vitamin B(12) production from crude glycerol by Propionibacterium freudenreichii ssp. shermanii. In the first step, using Plackett-Burman design, five of 13 tested medium components (calcium pantothenate, NaH(2)PO(4)·2H(2)O, casein hydrolysate, glycerol and FeSO(4)·7H(2)O) were identified as factors having significant influence on vitamin production. In the second step, a central composite design was used to optim ...	2012	22178491
genome sequence of propionibacterium acnes type ii strain atcc 11828.	propionibacterium acnes is an anaerobic gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). here we present the complete genome sequence for the commercially available p. acnes type ii reference strain atcc 11828 (i. nagy et al., microbes infect. 8:2195-2205, 2006) recovered from a subcutaneous abscess.	2012	22156398
novel in situ product removal technique for simultaneous production of propionic acid and vitamin b12 by expanded bed adsorption bioreactor.	a new type of in situ product removal (ispr) technique of expanded bed adsorption (eba) bioreactor was studied to simultaneously produce extracellular propionic acid and intracellular vitamin b12 by propionibacterium freudenreichii cicc 10019. resin screening experiments showed that the zga330 resin have the best biocompatibility and highest adsorption for propionic acid. through the eba bioreactor, propionic acid could be recovered efficiently by semi-continuous recirculation of the unfiltered ...	2012	22082511
Heme Oxygenase-1 Alleviates Mouse Hepatic Failure through Suppression of Adaptive Immune Responses.	Heme oxygenase-1 (HO-1) has protective effects on liver damage induced by noxious stimuli. The mechanism of action of HO-1 is not well understood. In the present study, we investigate the effect of HO-1 in a model of fulminant hepatic failure induced by Propionibacterium acnes and lipopolysaccharide (LPS). The expression of HO-1 mRNA and protein in the liver was increased after repeated administration of the HO-1 inducer cobalt protoporphyrin IX. We found that HO-1 protected mice from acute live ...	2012	21946119
Efficient electricity generation from sewage sludge usingbiocathode microbial fuel cell.	Microbial fuel cells (MFCs) with abiotic cathodes require expensive catalyst (such as Pt) or catholyte (such as hexacynoferrate) to facilitate oxidation reactions. This study incorporated biocathodes into a three-chamber MFC to yield electricity from sewage sludge at maximum power output of 13.2±1.7W/m(3) during polarization, much higher than those previously reported. After 15d operation, the total chemical oxygen demand (TCOD) removal and coulombic efficiency (CE) of cell reached 40.8±9.0% and ...	2012	22078254