Publications

the effect of nutritional state on neuromuscular transmission in the rat.	1. evoked end-plate potentials (e.p.p.s) were recorded in phrenic nerve-hemidiaphragm preparations from rats which had been subjected to periods of dietary restriction. 2. the mean quantum content of the first e.p.p. of trains of e.p.p.s was significantly increased after 1 week of dietary restriction in 30-day-old but not in 110-day-old rats. 3. the mean quantum content of plateau e.p.p.s elicited at a frequency of 10 hz was not significantly affected by brief periods of dietary restriction in e ...	1979	220414
[sociological aspects in breast cancer. illness and death are part of being human].		1979	254323
comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo.	the antibacterial activities of three aminopenicillins ampicillin, epicillin and amoxycillin were compared in vitro and in vivo. the minimum inhibitory concentrations (mic) of the three penicillins were very similar and the compounds were active against non-beta-lactamase-producing strains of escherichia coli, salmonella and shigella species, proteus mirabilis, haemophilus influenzae and neisseria gonorrhoeae. streptococci including streptococcus faecalis, and non-beta-lactamase-producing staphy ...	1979	256524
feline eosinophilic granuloma complex: a clinicoepidemiologic study of 32 cases.		1979	257955
[comparison of the antibacterial activity of ticarcillin with other antibacterial agents (author's transl)].	antibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin, amoxicillin, cefuroxime, clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital. growth of more than 90% of gram-negative anaerobic rod bacteria was inhibited by ticarcillin at its concentration of 100 micrograms/ml. strains resistant to ticarcillin showed cross resistance against both sulbenicillin and amoxicillin. antibacteri ...	1979	258675
antibiotic sensitivity and synergism of 'penicillin-tolerant' staphylococcus aureus.	15 staphylococcus aureus strains were isolated from 15 patients with staphylococcal bacteremia. eight of these strains were shown to be tolerant for cloxacillin. cloxacillin-tolerant strains were also tolerant for most of the cephalosporins tested except for cephapirin. strains were not tolerant for clindamycin and gentamicin. penicillin-tolerant staphylococci showed a high degree of synergism between gentamicin and cloxacillin or cephalothin and gentamicin.	1979	260698
[human science. self-awareness. (3). awareness of the ego].		1979	260804
[effect of heat on accidental organochlorine insecticide residues in a non-poisonous mushroom (níscalo) (lactarius deliciosus l)].		1979	263644
experimental studies on the biological properties of bordetella pertussis.		1979	262507
[serological study of postvaccinal measles immunity in the absence of a booster effect and in measles foci].		1979	262711
characteristics of the event-related brain potential to noxious thermal stimulation in man.		1979	262716
significance of lipid peroxidation in the genesis of chronic vasospasm following rupture of an intracranial aneurysm.		1979	290253
anti-androgen tsaa-291. iv. effects of the anti-androgen tsaa-291 (16 beta-ethyl-17 beta-hydroxy-4-oestren-3-one) on the secretion of gonadotrophins.	effects of the anti-androgen tsaa-291 on the gonadotrophin secretion were studied. (1) a single subcutaneous or oral administration of tsaa-291 and its caproate induced the ovulation in the proestrous rat of which the spontaneous ovulation was blocked by the treatment with chlorpromazine. (2) a single subcutaneous administration of tsaa-291 at 2.4 mg/kg to the adult male rat induced only a slight elevation in the serum lh and fsh levels at 30 min after the administration. successive intramuscula ...	1979	294107
cochlear nonlinear phenomena in two-tone responses.		1979	294691
the ultrastructure of surfaces of positively identified cells in the human urinary sediment. a correlative light and scanning electron microscopic study.	surfaces of cells in the urinary sediment, postively identified by light microscopy (lm) were studied by scanning electron microscopy (sem). about 35% of benign urothelial cells were characterized by the presence of short, stubby microvilli (mv). about 60% of such cells had surface microridges, and the remaining cells had surface blebs. squamous epithelial cells were characterized primarily by microridges or by a mixture of microridges with short microvilli. urothelial cancer cells had various s ...	1979	294764
childhood pneumonia at goroka hospital.	we have reviewed the clinical presentation of pneumonia to the goroka paediatric ward. in comparison to survivors, children dying from pneumonia more often (p less than 0.05) had malnutrition (weight-for-age under 80%), anaemia (haemoglobin under 9g%), and a marked leucocytosis (total white cell count over 30,000 cells per c.m.m.). children dying from pneumonia had been ill for longer and had been given more antibiotics prior to admission. there was no significant difference between children dyi ...	1979	299332
haemophilus influenzae type d pneumonia.		1979	310640
serum chloramphenicol levels and the intramuscular bioavailability of several parenteral formulations of chloramphenicol in ruminants.		1979	419516
the effect of oxazepam on ocular readaptation time.	the readaptation time (rat) is the interval during which a person exposed to a bright intense light flash cannot perceive a given target. in this study the target used was an optokinetic pattern and the elicited nystagmus (okn) was registered with electrooculography (eog), thus giving an objective registration of rat. oxazepam in therapeutic doses was given to five healthy subjects and the rat and serum concentrations of the drug were registered simultaneously at different time intervals. an alm ...	1979	419971
influence of somatostatin on glucagon- and epinephrine-stimulated hepatic glucose output in the dog.	glucose kinetics were measured using [3-3h]glucose in conscious dogs during the infusion of: 1) glucagon alone; 2) glucagon plus somatostatin with insulin replacement; 3) epinephrine alone; and 4) epinephrine plus somatostatin with insulin and glucagon replacement. infusion of glucagon alone resulted in a 10-15 mg/dl rise in plasma glucose and a transient 45% rise in glucose production. when somatostatin and insulin were added, a four- to fivefold greater rise in plasma glucose and glucose produ ...	1979	420283
permeability of human erythrocyte membrane vesicles to alkali cations.	the permeability of inside-out and right-side-out vesicles from erythrocyte membranes to inorganic cations was determined quantitatively. using 86rb as a k analog, we have measured the rate constant of 86rb efflux from vesicles under equilibrium exchange conditions, using a dialysis procedure. the permeability coefficients of the vesicles to rb are only about an order of magnitude greater than that of whole erythrocytes. furthermore, we have measured many of the specialized transport systems kno ...	1979	420826
distribution of o6-methylguanine in rat dna following pretreatment in vivo with methylnitrosourea.		1979	421194
anaphylaxis in guinea-pig peripheral airways in vitro.	the contributions made by histamine, prostaglandins (pg) and slow reacting substance (srs-a) to anaphylactic contractions in isolated guinea-pig lung were investigated. histamine, pgf2alpha and srs-a induced isometric contractions in lung parenchymal strips and in tracheal smooth muscle. the effective concentrations of the autacoids were the same in lung strips and tracheas. anaphylactic contractions in lung strips from bovine serum albumin sensitised animals were not affected by mepyramine (5 x ...	1979	421743
an azoospermic male with a y/autosome translocation.	this report describes an azoospermic male carrying a y/autosome translocation. the patient had a 46,x,t(y;10)(q12;p13) chromosome complement in a lymphocyte culture. the cytogenetic study of this patient is described, together with testicular histology, spermiogram, hormone levels, and clinical history.	1979	422199
epidermal cells adhere preferentially to type iv (basement membrane) collagen.	epidermal cells from adult guinea pig skin attach and differentiate preferentially on substrates of type iv (basement membrane) collagen, compared to those of types i--iii collagen. in contrast, guinea pig dermal fibroblasts attach equally well to all four collagen substrates. fibronectin mediates the attachment of fibroblasts but not of epidermal cells to collagen.	1979	422650
interactions of trichophyton mentagrophytes and micrococci on skin culture.	scanning electron microscopy was used to search for local or limited synthesis of antibiotics by a strain of trichophyton mentagrophytes. micrococcus luteus, which was susceptible to penicillin and to the dermatophyte when both were cultured on agar media, displayed morphological alterations of flattened walls, invagination, enlargement, and collapse in skin cultures with the fungus. penicillinase did not neutralize these effects. a control strain of staphylococcus spp with poor sensitivity to p ...	1979	422876
the inhibition and reactivation of human maternal and fetal plasma cholinesterase following exposure to the organophosphate, dichlorvos.		1979	423703
a study of d-glucose uptake by small intestine of rats following in vivo vinblastine treatment.	the pharmacokinetics of tritiated vinblastine in rats has indicated a considerable excretion of the alkaloid through bile into the intestinal lumen. the present study was undertaken to find out whether the presence of the alkaloid in the lumen of small intestine alters the normal transport of nutrients across the small intestine. this was done by measuring the in vitro d-glucose uptake by slices of small intestine of rats pretreated with vinblastine. vinblastine pretreatment was done by filling ...	1979	424442
inhibitory effect of prostaglandin f2 alpha on the growth of a hormone-dependent rat mammary tumor.	growth of the rat hormone-dependent mammary adenocarcinoma mtw-9 was inhibited by prostaglandin f2alpha (pgf2alpha) this inhibition of tumor growth was associated with a marked reduction in serum progesterone concentrations. the inhibitory effect of pgf2alpha on tumor growth was abolished by concomitant injections of progesterone. the growth rates of coimplanted prolactin-secreting pituitary tumor mttw-5 and plasma concentrations of prolactin and estradiol were not affected significantly by pgf2 ...	1979	427787
processing and use of crop residues including alfalfa press cake.	better utilization of roughage can improve the production of red meat and dairy products. feed value of low grade roughages can be greatly increased by chemical and/or physical treatments. both alkali and ammonia treatments are already being used commercially in europe, although there is still opportunity for process improvement. in the united states, the low cost of grain and oilseeds makes the economics of processing cellulosic byproducts less desirable, but their eventual use seems inevitable ...	1979	428576
reconstitution of discoidin hemagglutination activity by lipid extracts of dictyostelium discoideum cells.	the developmentally regulated carbohydrate binding protein discoidin (from dictyostelium discoideum) has been purified in a nonagglutinating form. while substantial agglutination activity is present in cell lysates, this activity is consistently lost upon affinity purification of discoidin. the lack of agglutination activity is not due to a mutational event or a nutritional deficiency. the carbohydrate binding site of the protein is functional, and dissociation of the oligomeric protein into sub ...	1979	429337
carcinoma of the breast associated with hypercalcemia and the presence of parathyroid hormone-like substances in the tumor.	a woman with metastatic carcinoma of the breast developed hypercalcemia 39 months after mastectomy. the hypercalcemia remitted after treatment but recurred 12 months later, accompanied by elevated levels of serum immunoreactive parathyroid hormone (pth). a urea/hc1 extract of hepatic metastases contained immunoreactive pth, material which stimulated the resorption of fetal rat bone in tissue culture, and material which stimulated chick renal adenylate cyclase activity. these findings strongly su ...	1979	429476
augmentation of puerperal lactation by oral administration of sulpiride.	the effect of oral administration of sulpiride on prl secretion and initiation of puerperal lactation was studied in 130 randomly selected primiparous nursing mothers. sixty-six women were given 50 mg sulpiride orally twice a day during the first 7 days of the puerperium (sulpiride group). sixty-four women were given a placebo in the same way (control group). the mean (+/-se) total milk yield during the first 5 postpartum days in the sulpiride group (1211.7 +/- 65.0 ml) was significantly greater ...	1979	429499
a seasonal variation study of 25-hydroxyvitamin d3 serum levels in normal humans.	a population residing in the approximate area of kalamazoo, mi (latitude north, 42 degrees 17' 29''; longitude west 85 degrees 35' 14''), was examined to determine the influence of seasonal variation on human 25-hydroxyvitamin d3 serum levels. males and females, ranging in age from 16--64 yr of age and judged normal based on laboratory evaluation and physical examination, participated in the 12-month study. measurement of 25-hydroxyvitamin d3 serum levels was made by high performance liquid chro ...	1979	429522
simulated hyperglycemic hyperosmolar syndrome. impaired insulin and epinephrine effects upon lipolysis in the isolated rat fat cell.	these investigations were designed to evaluate the effect of excess glucose and sodium chloride on lipolysis in the isolated adipocyte under normal and modelled pathological conditions simulating the hyperglycemic hyperosmolar syndrome. isolated rat fat cells were incubated in the presence of various combinations of sodium chloride, glucose, epinephrine, and insulin. lipolysis was measured as glycerol and free fatty acid release, and total medium osmolarity as milliosmoles per liter by freezing ...	1979	429561
characteristics of volume reabsorption in rabbit superficial and juxtamedullary proximal convoluted tubules.	segments of superficial and juxtamedullary proximal convoluted tubules of the rabbit were perfused in vitro to examine the mechanisms responsible for net volume reabsorption. the very early postglomerular segments were not studied. fluid reabsorptive rates and transepithelial potential differences were compared under various conditions: (a) with perfusate that simulated glomerular filtrate; (b) with perfusate that lacked glucose, amino acids, and acetate and that had hco(3) and cl concentrations ...	1979	429562
a laboratory model for the investigation of contact transfer of micro-organisms.	the model was based on grasping a fabric-covered bottle contaminated with a strain of staphylococcus saprophyticus, then grasping a sterile fabric-covered bottle and counting the organisms transferred. when the donor fabric was moist 10% of the available cells passed onto the hands, but this fell to 0.05% when the inoculum dried. transfer from wet hands to the fabric amounted to 85%, but in the complete model only 0.06% of the available cells were transferred. the model was used to assess simple ...	1979	429788
a female-like rise in luteinizing hormone and follicle-stimulating hormone after gonadectomy in male rats induced by oestradiol pretreatment.		1979	429946
variations in concentrations of prolactin, luteinizing hormone, growth hormone and progesterone in the plasma of broody bantams (gallus domesticus).	the concentrations of prolactin, lh, progesterone and gh were measured in the blood of broody bantam hens. the concentration of prolactin was at its highest when the birds began to incubate their eggs and in six out of nine hens it tended to remain raised until the eggs hatched. the increase in the concentration of prolactin was small: in incubating hens it was only 23% higher than in hens caring for their young and 14% higher than in laying hens (p less than 0.05 for both comparisons). the conc ...	1979	429952
interaction of zinc and essential fatty acids in the rat.	three experiments were performed to investigate the possibility of a physiological relationship between zinc and essential fatty acids (efa). male weanling rats were fed diets low in zinc, efa or both and their growth rates, dermal scores and tissue fatty acid profiles determined. in experiment 1, a basal soybean protein diet containing 7 ppm of added zinc and approximately 300 ppm efa was used in a 2 x 2 factorial design: low zn-low efa; adequate zn-low efa; low zn-adequate efa and adequate zn- ...	1979	430250
brain carbohydrate metabolism during experimental haemophilus influenzae meningitis.	five-day-old infant rats which acquire haemophilus influenzae b bacteremia and meningitis after intranasal inoculation have a transient depression in weight gain (2 days), but then continue to grow at the same rate as strain u--11 inoculated controls. brain lactate, glucose, and glycogen concentrations increase during the first 5 days of disease in infected animals. the increase in brain glycogen can be accounted for by an influx of glycogen containing polymorphonuclear leukocytes. the increased ...	1979	432002
plasma volumes and hematocrits in rats with chronic sinoaortic denervation hypertension.	plasma volume changes were assessed in female wistar rats with neurogenic hypertension induced by sinoaortic denervation, sad. tail veins of conscious, restrained rats were used for injection of evans blue dye and for sampling into microhematocrit tubes. only at 3 days did total plasma volume of sad rats show a modest reduction of about 16% (p less than 0.05 vs. sham-operated plus unoperated controls). at 3, 6, and 13 wk, sad mean body weight, plasma volume, and sodium concentration were similar ...	1979	434179
effect of bethanechol, gastrin i, or cholecystokinin on myoelectrical activity.	the purpose of this study was to determine the effect of bethanechol, gastrin i, or the octapeptide of cholecystokinin (cck-op) on the smooth muscle of the isolated cat colon. myoelectrical activity was recorded with monopolar glass-pore electrodes. slow-wave frequency was 5.9 +/- 0.2 cycles/min during the basal period. slow waves were generally coupled during the control period and the apparent propagation velocity was predominantly aborad at a velocity of 3.8 +/- 0.4 mm/s. spike activity was s ...	1979	434201
peristalsis in distal colon of the rabbit: an analysis of mechanical events.	the mechanical behavior of isolated segments of rabbit distal colon was studied by experimental and theoretical techniques. the isometric isovolumic preparation was adopted to obtain records of endoluminal pressure, force, and wall morphology during 59 spontaneous and 53 electrostimulated peristaltic contractions. on strips of longitudinal and circular muscle, excised from the same segments, the tension-velocity and tension-length relationships were also measured. to describe mechanical events o ...	1979	434202
effects of sympathetic nerves on cerebral blood flow in awake dogs.	although cerebral blood vessels are densely innervated by sympathetic nerve fibers, the functional significance of the nerves is controversial. because previous studies have been primarily performed in anesthetized animals, it is possible that failure to observe prominent neural control of the cerebral circulation was secondary to anesthetic-induced depression of the sympathetic nervous system. therefore, we studied sympathetic control of the cerebral circulation in 11 awake chronically instrume ...	1979	434219
post mortem stability of catecholamines in discrete regions of rat brain.	male sprague-dawley rats (200-300 g) were sacrificed by cervical dislocation and left either at room temperature (21-23 degrees c) for periods of 1, 2, and 4 hours or in the refrigerator (4-5 degrees c) for periods of 1, 2, 4, 8, 16, and 24 hours. the brains were left in the intact animals in order to stimulate human autopsy materials. at the end of each period, the rat was decapitated and the brain removed and immediately dissected into the following regions: cerebral cortex, striatum, midbrain ...	1979	441508
copper, zinc and molybdenum in goat liver.		1979	443140
acute haemophilus pneumonia in childhood.	in our hospital haemophilus influenzae type b seems to be a common cause of acute childhood pneumonia. in the past five years, 34 children with acute haemophilus pneumonia were identified. although these children generally had an uncomplicated segmental pneumonia associated with a bacteremia, 13 of the children had pneumonia with a pleural effusion. these children with haemophilus pneumonia represented 18% of the children hospitalized with systemic haemophilus disease and almost a third of those ...	1979	443216
distribution and inhibition characteristics of human brain monoamine oxidase.		1979	444264
[submicroscopic organization of human metaphase chromosomes].		1979	446259
[diabetic neuropathic cachexia (author's transl)].	marked weight loss with cachexia together with severe depression and pain from symmetrical peripheral neuropathy were noted in a 66-year-old man, known to have had diabetes for six years, which required insulin on admission to hospital. the patient died of bronchopneumonia after one year. the severe neuropathy was proven both neurophysiologically and at necropsy. there was no diabetic retinopathy and no histological evidence of renal glomerulosclerosis. there was no evidence of a malignant tumou ...	1979	446296
transposition of the great arteries: possible risk factor for haemophilus influenzae type b meningitis.		1979	448485
ketone bodies are selectively used by individual brain regions.	close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. the results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.	1979	451608
[morphology of the microcirculatory bed of the vascular coat of the human eye].	recently ophthalmologists got interested in microcirculatory bed of the choroid (the main collector of blood in the eye) because of the vascular layer was studied in 25 eyes of persons who had died suddenly and had no eye pathology during their lives. the age was from 11 to 70 years. v. v. kuprianov's method of impregnation was used. structural peculiarities of the choroid microcirculatory bed were presented; its changes were stated to depend on functional importance of the given segment of the ...	1979	454192
petechial hemorrhage in the ciliary processes of thrombocytopenic rabbits. an electron microscopic study.		1979	459929
intracellular hyperthermia. a biophysical approach to cancer treatment via intracellular temperature and biophysical alterations.	this paper introduces a new multi-disciplinary "intracellular" biophysical treatment of cancer. the basic concept uses locally induced heat energy after tumor phagocytosis of submicron particles whose composition permits magnetic excitation. the key to this process is the utilization of the cancer cell membrane to contain the energy within the cancer cell. any magnetic or electric dipole contained within or introduced into the cell, or that is capable of being produced by an external field, can ...	1979	459972
doctors and torture.		1979	460002
[interaction of insulin and its receptors in the muscles: specific i125 binding with plasma membranes of the skeletal muscle of rat].	a preparation of plasmatic membranes of the rat skeletal muscle was obtained which was used to characterize the interaction of insulin with its receptors in the myocyte. it was shown that insulin-125i binding by the membranes depended on the incubation time and temperature; the maximum binding occurred at 4 degrees, although the binding rate was low at this temperature. the degrading of labeled insulin at 4 degrees c did not exceed 1% in the course of 24 hours of incubation with the membranes. c ...	1979	461385
adenosine content of skeletal muscle during active hyperemia and ischemic contraction.	if newly formed adenosine is the mediator of active hyperemia in skeletal muscle, tissue adenosine must increase and remain elevated during sustained muscle contraction. we tested this prediction using isolated canine anterior calf muscles. muscle samples were obtained before and during contraction by punch biopsy and adenosine was measured by spectrophotometric enzyme assay. tissue adenosine content didnot increase significantly above the precontraction level during either the 2- or 6-hz contra ...	1979	464063
effects of miconazole and dodecylimidazole on sterol biosynthesis in ustilago maydis.	miconazole at minimal fungitoxic concentrations inhibits ergosterol biosynthesis in sporidia of ustilago maydis by interference with sterol c14 demethylation. the action is analogous to that of the fungicides triarimol and fenarimol. the fungicide 1-dodecylimidazole at low concentrations (0.1 to 0.25 mug/ml) inhibits sterol c14 demethylation; however, at higher concentrations (1.0 mug/ml or greater) it also inhibits 2,3-oxidosqualene cyclization and subsequent transmethylation. it is postulated ...	1979	464593
environmental enrichment and brain chromatin.		1979	464978
in vitro activity of furazlocillin (bay k 4999) compared with those of mezlocillin, piperacillin, and standard beta-lactam antibiotics.	the activity of furazlocillin (bay k 4999) was compared with those of mezlocillin, piperacillin, and standard beta-lactam antibiotics against a number of gram-positive and gram-negative organisms. these new expanded-spectrum penicillins were less active than penicillin g against most gram-positive organisms. furazlocillin, mezlocillin, and piperacillin showed activity comparable to ampicillin and penicillin g against haemophilus influenzae and penicillin-susceptible neisseriae, respectively. non ...	1979	475364
comparison of a micromethod for performance of the serum bactericidal test with the standard tube dilution method.	a micromethod for performance of the serum bactericidal test is described, and the results obtained with this method are compared with those obtained with the standard tube dilution macromethod. an agreement within +/- 1 dilution was achieved in 23 of 25 (92%) determinations of the serum bactericidal titer. the micromethod used approximately one-third of the amount of pooled normal human serum and of the technician's time required for performance of the macromethod. the micromethod offers an acc ...	1979	475373
the interaction of heparin with human alpha-thrombin: effect on the hydrolysis of anilide tripeptide substrates.		1979	475396
hormonally induced tumors of the reproductive system of parabiosed male rats.	parabiosis of intact male rats to castrated males or oophorectomized females for a period of approximately 20 months resulted in three interstitial cell tumors of the testis. when unilateral nephrectomy was added to the parabiotic procedure in ten pairs, eight interstitial cell tumors of the testis and four adenocarcinomas of the prostate occurred in the target male parabionts. these changes were preceded by elevations in luteinizing and follicle-stimulating hormone levels in the serum of the ca ...	1979	476635
chlamydial genital infections: a growing problem.		1979	478491
partial trisomy for the long arm of chromosome 7 due to familial balanced translocation.	a partial trisomy for the distal segment of the long arm of chromosome 7 (bands q32 replaced by qter) was observed in a severely retarded child with somatic and cns anomalies. the phenotypically normal father and paternal grandmother had a balanced reciprocal translocation between the long arm of a chromosome 2 and the long arm of a chromosome 7: 46,xx-xy,t(2;7) (q37;q32). the clinical features of the child at birth and at the ages of 5 months and 2 years are compared with those previously repor ...	1979	478537
fatal haemophilus influenzae endocarditis diagnosed by echocardiography in an infant.	a 1-year-old boy was admitted to the hospital with haemophilus influenzae meningitis. on the second hospital day a heart murmur heard on admission seemed louder. no signs of congestive heart failure were present. an echocardiogram demonstrated a persistent echo-dense mass behind the anterior leaflet of the mitral valve. a presumptive diagnosis of endocarditis was made. after ten days of antibiotic treatment the child was considerably improved. treatment was continued for endocarditis. over the n ...	1979	481970
comparison of the activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and bay k 4999 against gram-negative organisms.	the in vitro activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and bay k 4999 were compared with those of ampicillin and ticarcillin against 336 enterobacteriaceae, 109 nonfermenters, 55 neisseria, and 28 haemophilus influenzae isolates. bay k 4999 displayed the largest spectrum of activity and had lower minimal inhibitory concentrations than any of the other penicillins against all of the species tested. piperacillin showed the same spectrum but was slightly less ac ...	1979	485123
treatment of bacterial meningitis with intravenous amoxicillin.	eleven children with bacterial meningitis were treated intravenously with amoxicillin sodium to evaluate the efficacy of the parenteral form of amoxicillin for this serious infection and to measure the penetration of the drug into cerebrospinal fluid (csf). the infecting organisms were haemophilus influenzae in nine cases and streptococcus pneumoniae in two. nine patients had optimal responses to amoxicillin sodium, 200 mg/kg per day for 14 days. bacteria were also eradicated from csf of the oth ...	1979	485128
clinical and bacteriological evaluation of cefoxitin therapy in children.	cefoxitin, a parenteral cephamycin beta-lactam antibiotic, was evaluated for safety and efficacy in children with bacterial infections other than meningitis. twentysix patients between 3 months and 7 years of age were treated with 80 to 160 mg/kg per day. the most common diagnoses were cellulitis (13 patients), pneumonia (5 patients), and bone and joint infection (4 patients). nine patients were bacteremic. the most frequently recovered pathogens were staphylococcus aureus (six patients), haemop ...	1979	485129
a modified quantitative precipitin test which is rapid, sensitive and reproducible.	a modification of the standard quantitative precipitin test is described. the new procedure, which utilizes polyethylene glycol (peg) at both the 37 degrees c and 4 degrees c incubation stages, provides a convenient quantitative precipitin test assay which is more reliable and much faster than the standard assay. moreover, the modified or peg assay gives a quantitative measure of antibody concentration even when antisera of low titre are tested. the sensitivity of the capillary-tube test is also ...	1979	489988
comparative pharmacokinetics of amoxicillin and ampicillin in infants and children.	the pharmacokinetics of amoxicillin and ampicillin were studied in 24 infants and children. mean peak serum concentrations of 5.4 micrograms/ml in fasting and 3.2 micrograms/ml in nonfasting patients were observed after 15 mg/kg amoxicillin doses. area under the curve values and serum half-life values were similar in fasting and nonfasting patients. the pharmacokinetics of amoxicillin (15 mg/kg) were compared to those of ampicillin (25 mg/kg). peak serum concentrations, area under the curve valu ...	1979	492836
influenza virus infection of a newborn rats: virulence of recombinant strains prepared from a cold-adapted, attenuated parent.	infant rats were infected with one of a series of influenza a viruses. the growth of viruses in the turbinates or lungs, and the ability of virus infection to potentiate a subsequent bacterial infection by haemophilus influenzae (hib), were measured. the three virus strains known to be virulent for man grew to relatively high titres of 10(5.2)--10(6.8) ebid50/ml in the turbinates of infant rats at 48 hours post-infection, and virus infection enhanced subsequent systemic infection following intra ...	1979	496643
post-synthetic modifications of nuclear proteins. high mobility group proteins are methylated.		1979	496960
effects of vitamin a deficiency on hepatic and extrahepatic mixed-function oxidase and epoxide-metabolizing enzymes in guinea pig and rabbit.		1979	497022
reciprocal metabolic effect of benzene and its methyl derivatives in rats. i. study in vivo.		1979	497503
distribution and fate in the rabbit of liposomes containing [131i]-sodium iodide.		1979	497576
an effect of neostigmine on the response of the rat anococcygeus muscle to field stimulation [proceedings].		1979	497579
the neuromuscular blocking action of some cyclic analogues of choline [proceedings].		1979	497607
an xyy man.	this case report describes a young man with a 47, xyy karyotype who was convicted of arson. he suffered from a cardiac disorder which may well have been part of the xyy syndrome rather than a chance association. his abnormal karyotype was disclosed in court and used by the defence in a plea in mitigation.	1979	497632
the effect of urea on the structure of nuclear ribonucleoprotein particles from rat liver.		1979	499209
plasma and urinary levels of triamterene and certain metabolites after oral administration to man.	the plasma and urinary levels of triamterene and two metabolites were measured using a specific method of analysis. urinary excretion was completed after 48 h, which permitted a rough estimate of its half-life as longer than two hours. the areas under the curve were 672.5 +/- 160.3 and 1.311.3 +/- 399.1 micrograms/ml x h after the triamterene 150 mg and 300 mg p.o., respectively and correspondingly 4.2 +/- 1.4% and 3.7 +/- 0.6% of the dose were excreted as unchanged drug. the principal metabolit ...	1979	499298
effect of glomerulopressin on ovarian blood flow in dogs.	the present study showed that glomerulopressin decreased ovarian blood flow in normal dogs and that this effect could be inhibited by treatment with indomethacin. in addition diabetic dogs had a high plasma level of glomerulopressin and a low ovarian blood flow that was shown to increase after treatment with indomethacin. this suggests that the low ovarian blood flow in diabetis might be due to a prostaglandin synthesizing effect of glomerulopressin.	1979	500003
behavior of vaccine revertants of temperature-sensitive mutants of influenza virus in ferret tracheal organ culture.	a live attenuated influenza vaccine candidate was not genetically stable when administered to some children who lacked antibody to surface proteins of the virus. to obtain additional biological information about these revertants, the vaccine strain, the wild-type parental strain, and isolates recovered from inoculated children during a vaccine trial were evaluated in ferret tracheal organ culture for effects on the ciliated epithelium and replication at both permissive and restrictive temperatur ...	1979	500202
quantitative distribution of lysosomal hydrolases in the rat nephron.	the activities of n-acetyl-beta, d-glucosaminidase (nag, ec 3.2.1.30), beta, d-galactosidase (beta-gal, ec 3.2.1.23) and acid phosphatase (ac-pase, ec 3.1.3.2) were measured in the glomeruli, five segments of the proximal and four segments of the distal tubule of normal male wistar rats. the activities of nag and beta-gal are 3- to 5-fold higher in the first part of the proximal tubule than in other segments and very low in glomeruli. we propose that the distribution of these two glycosidases re ...	1979	500408
importance of animal products in the human diet.	increased interest in food, nutrition, and health has led to critical evaluation of the american diet by governmental, scientific, and consumer groups. the exact role of diet in health and disease continues to be debated. over the years trends in consumption of foods and nutrients have developed. these issues are examined. historically, animal products have played a key role in the overall health of americans. the contributions of animal products to human nutrition are emphasized along with an i ...	1979	500895
endothelial lesions after temporary clipping. a comparative study.	the effect of temporary clipping on the arterial endothelium of rats was examined with scanning electron microscopy. the opening pressure of four heifetz clips was modified by changing the springs. four different clip forces (20, 35, 45, and 65 gm), four periods of clipping (10, 30, 60, and 180 minutes), and three vessel diameters (smaller than 1 mm, 1.1 to 1.3 mm, and 1.4 to 2 mm) were compared. different grades of endothelial damage were observed. on gross examination the damage involved a det ...	1979	501405
six autopsy cases of eighteen trisomy.		1979	502440
the incorporation of intrastriatally injected [3h]fucose into electrophoretically separated synaptosomal glycoproteins. ii. the influence of passive avoidance training.	following intrastriatal injections of [3h]l-fucose, male albino rats served as (a) trained subjects in a step-down passive avoidance task, (b) stress controls receiving inescapable shock or (c) handled controls. at a series of time points after treatment the animals were sacrificed and the p2 fraction of the injected neostriatum was isolated. this tissue was electrophoresed on sds-polyacrylamide gels and radioactivity profiles were constructed from 1 mm gel slices. the profiles of trained subjec ...	1979	509242
ampicillin concentration in normal and pathological lung tissues after oral administration of bacampicillin.	following oral administration of 800 mg bacampicillin, the concentrations of ampicillin were determined in normal (n = 16) and pathological (n = 12) lung tissue after 3.6 and 9 hours in a total of 28 patients. the serum concentration was determined simultaneously. the mean peak serum concentration (+/- sd) after one hour was 9.7 +/- 7.2 micrograms/ml. the mean concentration (+/- sd) in normal lung tissues were, after 3, 6 and 9 hours, 3.73 +/- 1.10 micrograms/ml, 1.06 +/- 0.99 micrograms/ml, 0.1 ...	1979	511359
diagnosis of bacterial meningitis by gas-liquid chromatography. ii. analysis of spinal fluid.	the feasibility of gas-liquid chromatographic analysis of spinal fluid from dogs with experimental meningitis and from patients with meningitis was evaluated. normal canine and human spinal fluid contained consistent levels of palmitic and stearic acids, glucose, and trace amounts of glycerol. pneumococcal meningitis in dogs and humans was characterized by a complex fatty-acid pattern in spinal fluid similar to that seen in pneumococcal cells. spinal fluid from dogs with haemophilus influenzae m ...	1979	512413
[study of cefuroxime in pediatric field (author's transl)].	1. cefuroxime (cxm) was studied for absorption and excretion in 4 pediatric patients given one shot intravenous injection of 20 approximately 25 mg/kg. the following serum levels were determined: 24.5 approximately 38.0 micrograms/ml at 30 minutes (mean 33.3 +/- 6.1 micrograms/ml), 10.0 approximately 17.0 micrograms/ml at 1 hours (mean 13.9 +/- 3.3 micrograms/ml), 3.4 approximately 7.6 micrograms/ml at 2 hours (mean 5.2 +/- 1.9 micrograms/ml, 0.7 approximately 2.1 micrograms/ml at 4 hours (mean ...	1979	513299
[decrease in the number of tetracycline-resistant salmonella strains in the netherlands].		1979	514399
deleterious effects of leucine administration in endotoxin shock.		1979	515023
[studies on the pharmacokinetics of antidiabetic biduanide salts with depot effectiveness (proceedings)].		1979	515163
inhibition of drug oxidation and stimulation of nadph oxidase in vitro by doxorubicin and triferric-doxorubicin.	the electrophilic properties of the quinone-hydroquinone configuration of anthracycline antibiotics suggests a possible influence on cytochrome p-450-mediated mono-oxygenase reactions. both doxorubicin and triferric-doxorubicin (a derivative in which the quinone groups are blocked with iron) showed a similar dose-dependent inhibition of liver microsomal drug metabolism. a doxorubicin concentration-related stimulation of nadph oxidase activity was found to be linear but that for triferric-doxorub ...	1979	515168
frequency composition of brain-stem auditory evoked potentials.	it has been demonstrated by digital filtration and power spectra analysis that main energies of different components of human brain-stem auditory evoked potentials are concentrated in the following frequency bands: 400--1 000 hz for waves i and ii, 100--900 hz for wave iii, and 100--500 hz for waves iv--vi. the data obtained are compared with those published in scand audiol by terkildsen et al. (1975) and elberling (1976).	1979	515684
the activity of levamisole against benzimidazole resistant haemonchus contortus and trichostrongylus colubriformis.		1979	516343
[allergenic and anaphylactoid properties of carcinostatic compounds of platinum].	different effects of platinum salts on the organism were studied comparatively. the toxic effect was estimated by ld50; the carcinogenic one--by the action on ehrlich ascites tumor; the anaphylactoid effect was evaluated by the degree of the arterial pressure fall, the development of bronchospasm and an increased blood histamine level in cats under intravenous injection of platinum salts. the sensitization action of platinum salts was assessed on guinea pigs. all these effects are found to be de ...	1979	516565