Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| spatial distribution of enteric viruses and somatic coliphages in a lagoon used as drinking water source and recreation in southern brazil. | this study aimed to evaluate the contamination level of the peri lagoon, the main freshwater reservoir of santa catarina island, southern brazil, for human adenovirus (hadv), hepatitis a virus (hav), rotavirus species a (rva), and somatic coliphages (somcph). viruses were also investigated in sediments and their sensitivity against natural sunlight was analysed by studying their spatial distribution in different depths of the water column. a total of 84 water samples and 48 sediment samples were ... | 2016 | 27449740 |
| kidney injury marker 1 and neutrophil gelatinase-associated lipocalin in chronic kidney disease. | the current categorization of chronic kidney disease (ckd) is based on biomarkers of the glomerular function (estimated glomerular filtration rate, egfr) and injury (urinary albumin creatinine ratio, uacr) and provides information on the risk of death and of progression of kidney disease. however, there are gaps in knowledge regarding the risk stratification of elderly patients with egfr 45-60 ml/min/1.73 m2 and of younger patients with higher egfr but physiological albuminuria. in this regard, ... | 2016 | 27771693 |
| comprehensive profiling and characterization of cellular mirnas in response to hepatitis a virus infection in human fibroblasts. | hepatitis a virus (hav), the causative agent of acute hepatitis, grows slowly without causing any cytopathic effect (cpe) and lead to a persistent infection in the fibroblasts in vitro. mirnas play a key role in the viral pathogenesis and virus-host interactions. in this study, the comprehensive mirna expression profiles of hav-infected and uninfected fibroblasts were investigated by srna-seq and validated by rt-qpcr. the results showed that a total of 94 mirnas were differentially expressed dur ... | 2016 | 27590712 |
| sporadic adult acute viral hepatitis in northeast india is predominantly hepatitis a virus related. | 2016 | 27640427 | |
| a family cluster of hepatitis a virus due to an uncommon ia strain circulating in campania (southern italy), not associated with raw shellfish or berries: a wake-up call to implement vaccination against hepatitis a? | hepatitis a virus is a widely occurring disease, with different prevalence rates between countries in the north and west and those in the south and east. in italy endemicity is low/medium, but not homogeneously distributed: in the northern/central regions a large hepatitis a outbreak due to genotype ia, related to the consumption of contaminated mixed frozen berries, occurred between 2013 and 2014, whereas in southern italian regions recurrent outbreaks of hepatitis a, due to the ib genotype, st ... | 2016 | 27668904 |
| changes in cellular proliferation and plasma products are associated with liver failure. | to study the differences in immune response and cytokine profile between acute liver failure and self-limited acute hepatitis. | 2016 | 27917263 |
| single-dose universal hepatitis a immunization in one-year-old children in argentina: high prevalence of protective antibodies up to 9 years after vaccination. | single-dose hepatitis a virus (hav) vaccination was implemented in all argentinean children 12 months of age in 2005. previous studies demonstrated high prevalence of protective antibody response 4 years after single-dose vaccination. this study assessed long-term seroprotection against hav after vaccination. | 2016 | 27636725 |
| mavs-dependent host species range and pathogenicity of human hepatitis a virus. | hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. we describe a murine model of hepatitis a virus (hav) infection that recapitulates critical features of type a hepatitis in humans. we demonstrate that the capacity of hav to evade mavs-mediated type i interferon responses defines its host species range. hav-induced liver injury was associated with interfer ... | 2016 | 27633528 |
| comparison of concentration methods for detection of hepatitis a virus in water samples. | hepatitis a virus is a pathogen associated with water pollution. contaminated drinking water can cause hepatitis a outbreaks, lead to economic losses, and even threaten human lives. it is difficult to detect low levels of hepatitis a virus in water, so the virus must be concentrated in order to quantify it accurately. here, we present a simple, rapid, efficient technique for the concentration and detection of hepatitis a virus in water. our data showed that adding phosphate-buffered saline to th ... | 2016 | 27535067 |
| a review of immunogenicity and tolerability of live attenuated hepatitis a vaccine in children. | changing epidemiology of hepatitis a virus (hav) has led to an increased susceptibility of adolescents and adults to the infection. vaccination can remarkably reduce the incidence and associated morbidity of hav infection. this review is focused on the safety and efficacy of h2 strain derived live attenuated hepatitis a vaccine. we found the vaccine to be highly immunogenic with minimal or negligible safety issues. moreover, a single dose of live attenuated vaccine persists a long term immune re ... | 2016 | 27532370 |
| acute liver failure caused by hepatitis a virus with dengue coinfection. | 2016 | 27493466 | |
| a rare association of hepatitis a virus infection with type-1 diabetes. | patients with type-1 diabetes are predisposed to develop a spectrum of liver diseases, which includes fatty liver, steatohepatitis and cirrhosis. the association of hepatitis a infection with type-1 diabetes is extremely rare. to the best of our knowledge, our case is the first case report in children. we described a nine year-old girl who had type-1 diabetes and developed hepatitis a virus infection without complications. a review of the literature is also provided. | 2016 | 27478582 |
| hepatitis a virus vaccination in iranian soldiers needs more attention. | 2016 | 27458517 | |
| efficacy of domestic cooking inactivation of human hepatitis a virus in experimentally infected manila clams (ruditapes philippinarum). | the aim of this work was to evaluate the efficacy of domestic cooking in inactivating manila clams experimentally infected with human hepatitis a virus (hav). | 2016 | 27451131 |
| towards next-generation sequencing analytics for foodborne rna viruses: examining the effect of rna input quantity and viral rna purity. | detection and identification of viruses in food samples are technically challenging due largely to the low viral copy number in contaminated food items, and the lack of effective culture enrichment methods that are amenable to regulatory applications for many of the common foodborne viruses. using an illumina miseq platform and two hepatitis a virus (hav) cell-culture adapted strains as a representative enteric virus species, this study examined the limits of single-stranded rna (ssrna) viral de ... | 2016 | 27435336 |
| the impact of assumptions regarding vaccine-induced immunity on the public health and cost-effectiveness of hepatitis a vaccination: is one dose sufficient? | hepatitis a vaccination stimulates memory cells to produce an anamnestic response. in this study, we used a mathematical model to examine how long-term immune memory might convey additional protection against clinical/icteric infections. dynamic and decision models were used to estimate the expected number of cases, and the costs and quality-adjusted life-years (qalys), respectively. several scenarios were explored by assuming: (1) varying duration of vaccine-induced immune memory, (2) and/or va ... | 2016 | 27428611 |
| epidemiological and clinical analysis of hepatitis virus a infections during three successive outbreaks in sfax (tunisia) between 2007 and 2010. | to describe the epidemiological and clinical characteristics of hav infection during three successive outbreaks occurring between 2007 and 2010 in the governorate of sfax. epidemiological and clinical characteristics were retrospectively analyzed from the outbreak investigations. the diagnosis of acute hepatitis a was confirmed by elisa detection of immunoglobulin m serum antibodies to hav. 443 patients were identified and 159 of them investigated. their mean age was 12.2 years and the m/f ratio ... | 2016 | 27412977 |
| comparison of immunogenicity and persistence between inactivated hepatitis a vaccine healive® and havrix® among children: a 5-year follow-up study. | inactivated vaccines for hepatitis a virus (hav) infection are widely used in china. mass vaccination programs drive the need for data on long-term persistence of vaccine-induced protection. | 2016 | 27385349 |
| clinical features and transmission pattern of hepatitis a: an experience from a hepatitis a outbreak caused by two cocirculating genotypes in sri lanka. | sri lanka is one of the intermediate-endemic areas for hepatitis a virus (hav), and concerns exist about the increasing hav-susceptible population. in fact, sri lanka recorded a large hepatitis outbreak, possibly hepatitis a, around the end of the sri lankan war. it included more than 14,000 patients consisting of local residents, internally displaced personnel, and military personnel in the main combat zone. the outbreak had slowed down by october 2009; however, acute viral hepatitis continued ... | 2016 | 27382079 |
| comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis a vaccine in healthy chinese children aged 18 months to 16 years: results from a randomized, parallel controlled, phase iv study. | for large-scale immunization of children with hepatitis a (ha) vaccines in china, accurately designed studies comparing the safety and immunogenicity of the live attenuated ha vaccine (ha-l) and inactivated ha vaccine (ha-i) are necessary. a randomized, parallel controlled, phase iv clinical trial was conducted with 6000 healthy children aged 18 months to 16 years. ha-l or ha-i was administered at a ratio of 1: 1 to randomized selected participants. the safety and immunogenicity were evaluated. ... | 2016 | 27345175 |
| mean platelet volume in hepatitis a. | hepatitis a virus (hav) still continues to be a serious public health problem worldwide. mean platelet volume (mpv) is a marker of platelet function and activation. this study aimed to evaluate the relationship between mpv in acute hepatitis a patients as compared to the control group and to assess mpv as an acute phase reactant in acute hepatitis a. | 2016 | 27338056 |
| cost-effectiveness analysis of catch-up hepatitis a vaccination among unvaccinated/partially-vaccinated children. | since 2006, the us centers for disease control and prevention has recommended hepatitis a (hepa) vaccination routinely for children aged 12-23months to prevent hepatitis a virus (hav) infection. however, a substantial proportion of us children are unvaccinated and susceptible to infection. we present results of economic modeling to assess whether a one-time catch-up hepa vaccination recommendation would be cost-effective. | 2016 | 27317459 |
| naturally circulating hepatitis a virus in olive baboons, uganda. | 2016 | 27315373 | |
| invader assisted enzyme-linked immunosorbent assay for colorimetric detection of disease biomarkers using oligonucleotide probe-modified gold nanoparticles. | we successfully developed an invader assisted elisa assay (iaelisa) for sensitive detection of disease biomarkers. the method includes three key steps as follows; biotinylated detection antibody was at first used to capture targeted antigen by sandwich elisa. the biotinylated oligonucleotide was then attached to detection antibody via streptavidin. finally, the cascade invader reactions were employed to amplify the biotinylated oligonucleotide specific to the antigen so that detection of the ant ... | 2016 | 27301208 |
| investigation of parasitic and viral pathogens in mussels (mytilus galloprovincialis) in the gulf of izmir, turkey. | to investigate microsporidia spp. parasite, hepatitis a virus (hav), and norovirus (nov) contamination in mussels collected from 8 stations in the inner, middle, and outer regions of the gulf of izmir. | 2016 | 27279520 |
| application of laser correlation spectroscopy for measuring virus size. | dynamic light scattering method or laser correlation spectroscopy was applied to evaluation of the size of viruses. we measured correlation functions of the light scattered by human immunodeficiency viruses (hiv) and hepatitis a viruses (hav) and found that size of hiv-1 (subtype a and b) and hav virions were 104 nm and 28 nm, respectively. comparison of these findings with electron microscopy data for fixed samples of the same viruses showed good agreement of the results. | 2016 | 27270934 |
| propidium monoazide rtqpcr assays for the assessment of hepatitis a inactivation and for a better estimation of the health risk of contaminated waters. | the waterborne transmission of hepatitis a virus (hav), the main cause of acute hepatitis, is well documented. recently, two iso proposals for sensitive determination of this pathogen by rtqpcr in water and food have been published (iso/ts 15216-1 and iso/ts 15216-2), and could enable the formulation of regulatory standards for viruses in the near future. however, since detected viral genomes do not always correlate with virus infectivity, molecular approaches need to be optimized to better pred ... | 2016 | 27262550 |
| progressive liver failure post acute hepatitis a, over a three-month period, resulting in hepatorenal syndrome and death. | hepatitis a is a common viral illness worldwide. it usually results in an acute, self-limiting disease and only rarely leads to fulminant hepatic failure or any other complications. during the period of conflict in syria, and due to the damages to water infrastructure and poor sanitation, a dramatic increase in hepatitis a virus infection has been documented. here we report a rare case of a 14-year-old male whose hepatitis a was complicated with hepatorenal syndrome and subacute liver failure. t ... | 2016 | 27247182 |
| identification of enteric viruses in foods from mexico city. | foodborne viruses are a common and, probably, the most under-recognized cause of outbreaks of gastroenteritis. among the main foods involved in the transmission of human enteric viruses are mollusks, and fruits and vegetables irrigated with wastewater and/or washed with non-potable water or contaminated by contact with surfaces or hands of the infected personnel during its preparation. in this study, 134 food samples were analyzed for the detection of norovirus, rotavirus, and hepatitis a virus ... | 2016 | 27221088 |
| hepatitis a immunity and region-of-origin in a swiss prison. | purpose - the environmental and demographic characteristics of closed institutions, particularly prisons, precipitate morbidity during hepatitis a virus (hav) outbreaks. given the high prevalence of chronic liver disease and other risk factors in the prison setting, the purpose of this paper is to examine hav-immunity and its associated factors in this population. design/methodology/approach - the cross-sectional study was conducted in 2009: a serology screening for hav igg was carried out among ... | 2016 | 27219907 |
| development of a one-step duplex rt-pcr method for the simultaneous detection of vp3/vp1 and vp1/p2b regions of the hepatitis a virus. | the simultaneous detection and accurate identification of hepatitis a virus (hav) is critical in food safety and epidemiological studies to prevent the spread of hav outbreaks. towards this goal, a one-step duplex reverse-transcription (rt)-pcr method was developed targeting the vp1/p2b and vp3/vp1 regions of the hav genome for the qualitative detection of hav. an hav rt-qpcr standard curve was produced for the quantification of hav rna. the detection limit of the duplex rt-pcr method was 2.8 × ... | 2016 | 27197668 |
| pattern of hepatitis a virus epidemiology in nursing students and adherence to preventive measures at two training wards of a university hospital. | nursing students can be exposed to patients with hepatitis a virus (hav) and can represent a vehicle of transmission both for health personnel, patients and relatives. | 2016 | 27195012 |
| the syrian refugees crisis brings challenges to the health authorities in europe: hepatitis a virus is a case in point. | 2016 | 27194123 | |
| hepatitis a virus epidemiology in turkey as universal childhood vaccination begins: seroprevalence and endemicity by region. | this paper presents the results of a comprehensive examination of current distribution of hepatitis a virus (hav) seroprevalence and endemicity in turkey and the possible links between hav endemicity and socioeconomic development. we performed a systematic search in online resources published between january 2000 and august 2015. the 22 provinces were able to be assigned a hepatitis a endemicity level based on this systematic review. the incidence rates for symptomatic hepatitis a infection are ... | 2016 | 28621088 |
| first report of hepatitis e virus viremia in healthy blood donors from nepal. | the aim of this study was to detect the prevalence of hepatitis e virus (hev) in healthy blood donors so as to decipher the maintenance of (hev) reservoir if any. five hundred and eighty-one blood samples along with clinical information were collected from central blood bank, kathmandu between february and march 2014. samples were tested for hepatitis b virus surface antigen, anti-hepatitis c virus antibodies, anti-hepatitis a virus igm, hev antigen, hev viral load and anti-hev antibodies (igm a ... | 2016 | 28466048 |
| phenolic profile of centaurea aegyptiaca l. growing in egypt and its cytotoxic and antiviral activities. | centaurea aegyptiaca l (asteraceae), is one of the most attractive plants growing wildly in sinai, and is not well investigated for its phytochemical constituents. this study represents the first in-depth characterization of the phenolic profile of the aerial parts of c. aegyptiaca methanolic extract utilizing liquid chromatography (lc) combined with electrospray ionization (esi) tandem mass spectrometry (ms/ms). | 2016 | 28480370 |
| acute hepatitis a virus infection in patients hospitalised at the department of infectious diseases, medical university of lublin (eastern poland) in the years 2009-2015. | the aim of our study was to analyse all medical records from the years 2009-2015 for adult patients with acute hepatitis a virus (hav) infection who were hospitalised at the department of infectious diseases, medical university of lublin (eastern poland). during this 7-year study, there were only 5 hospitalised patients with confirmed hav infection. in the study group 4 out of 5 patients had travelled to hav-endemic areas (egypt, ukraine), and 3 of the hepatitis a cases were imported from egypt. ... | 2016 | 28856273 |
| [prevalence of antibodies to hepatitis a virus in healthcare workers and associated variables]. | vaccination against hepatitis a is recommended in risk groups, including healthcare workers. the objective of this study was to determine the prevalence of antibodies to hav (igg) among workers in the healthcare setting in order to establish criteria for vaccination. | 2016 | 23669502 |
| inactivation of viruses and bacteria on strawberries using a levulinic acid plus sodium dodecyl sulfate based sanitizer, taking sensorial and chemical food safety aspects into account. | the efficacy of levulinic acid (lva) in combination with sodium dodecyl sulfate (sds) in removal of foodborne viruses, enteric bacterial pathogens and their surrogates on fresh strawberries was investigated. inoculated strawberries were treated with potable water, sodium hypochlorite solution (50ppm), 0.5% lva plus 0.5% sds solution, and 5% lva plus 2% sds solution respectively for 2min, followed by spray-rinsing with potable water. water washing removed at least 1.0-log of the tested viral and ... | 2017 | 28668727 |
| detection of diverse viruses in alimentary specimens of bats in macau. | bats carry a variety of viruses, and some of them cause public health problems. macau, which is famous for its gambling industry, has a complex population structure. the globalization in such an international metropolis has enhanced the chance of disease transmission. therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases. here, we report the first surveillance of bat viruses in macau. in this study, we collected 1004 samples invo ... | 2017 | 28589292 |
| host differences affecting resistance and susceptibility of the second generation of a pekin duck flock to duck hepatitis a virus genotype 3. | earlier work suggested the possibility to anti duck hepatitis a virus genotype 3 (dhav-3) using the resistance breeding strategy. here, we report the creation of the second generations of a resistant pekin duck flock (designated z8r2) and a highly susceptible pekin duck flock (designated z8s2) and the investigation of their responses to dhav-3. experimental infection with dhav-3 at 7 days of age resulted in a high mortality (66.3%) in 11 susceptible z8s2 families and an extremely low mortality r ... | 2017 | 28674528 |
| raw rehmannia radix polysaccharide can effectively release peroxidative injury induced by duck hepatitis a virus. | duck viral hepatitis (dvh), caused by duck hepatitis a virus (dhav), is a fatal contagious infectious disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against dvh. | 2017 | 28638862 |
| comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis a virus genotype 1. | because of their better immunogenicity and the improved protection they afford, live attenuated vaccines derived from serial passaging in an abnormal host are widely used to protect humans or animals from certain pathogens. here, we used a virulent and a chicken embryo-attenuated duck hepatitis a virus genotype 1 to compare the different regulated immune responses induced by viruses with differing virulence. in this study, the attenuated strains had lower protein expression levels than the virul ... | 2017 | 28614378 |
| the 3d protein of duck hepatitis a virus type 1 binds to a viral genomic 3' utr and shows rna-dependent rna polymerase activity. | to explore the rna-dependent rna polymerase (rdrp) function of the 3d protein of duck hepatitis a virus type 1 (dhav-1), the gene was cloned into the pet-32a(+) vector for prokaryotic expression. the 3' untranslated region (3' utr) of dhav-1 together with a t7 promoter was cloned into the pmd19-t vector for in vitro transcription of 3' utr rna, which was further used as a template in rna-dependent rna polymerization. in this study, three methods were applied to analyze the rdrp function of the 3 ... | 2017 | 28600723 |
| effects of chrysanthemum indicum polysaccharide and its phosphate on anti-duck hepatitis a virus and alleviating hepatic injury. | to explore new effective anti-duck hepatitis a virus drugs, chrysanthemum indicum polysaccharide (cips) was phosphorylation modified using stmp-stpp method, and phosphorylated chrysanthemum indicum polysaccharide (pcips) was obtained. characteristic absorption peaks were observed in pcips using ir spectrum, suggested that cips was successfully modified. in addition, field emission scanning electron micro-scope (fe-sem) was used to observe the polysaccharides' surface features. in vitro, we found ... | 2017 | 28455254 |
| an outbreak of duck hepatitis a virus type 1 infection in japan. | in june 2015, a highly fatal and acute disease broke out in a duckling farm in hyogo prefecture, japan. the birds exhibited poor growth, reduced movement, lying in a dorsal recumbent position, depression, lethargy, ataxia and opisthotonus, with a high mortality rate of approximately 76%. by performing a reverse transcription-polymerase chain reaction (rt-pcr) using primers specific for duck hepatitis a virus type 1 (dhav-1), we obtained the pcr products of a predicted size. the nucleotide sequen ... | 2017 | 28413174 |
| a flavone-polysaccharide based prescription attenuates the mitochondrial dysfunction induced by duck hepatitis a virus type 1. | the principal target organ of duck hepatitis a virus type 1 (dhav-1) is duckling liver, which is an energy-intensive organ and plays important roles in body's energy metabolism and conversion. as the "power house" of the hepatocytes, mitochondria provide more than 90% of the energy. however, mitochondria are much vulnerable to the oxidative stress for their rich in polyunsaturated fatty acids. although previous researches have demonstrated that dhav-1 could induce the oxidative stress in the ser ... | 2017 | 28394931 |
| immunoprevalence to six waterborne pathogens in beachgoers at boquerón beach, puerto rico: application of a microsphere-based salivary antibody multiplex immunoassay. | waterborne infectious diseases are a major public health concern worldwide. few methods have been established that are capable of measuring human exposure to multiple waterborne pathogens simultaneously using non-invasive samples such as saliva. most current methods measure exposure to only one pathogen at a time, require large volumes of individual samples collected using invasive procedures, and are very labor intensive. in this article, we applied a multiplex bead-based immunoassay capable of ... | 2017 | 28507984 |
| genotypes of hepatitis a virus in turkey: first report and clinical profile of children infected with sub-genotypes ia and iiia. | hepatitis a virus (hav) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. it is important to characterize circulating strains of hav in order to prevent hav infections using efficacious vaccines. the aim of this study was the detection and characterization of the circulating strains of hav in turkey by performing serology, rt-pcr, sequencing and phylogenetic analysis. | 2017 | 28800730 |
| structures and corresponding functions of five types of picornaviral 2a proteins. | among the few non-structural proteins encoded by the picornaviral genome, the 2a protein is particularly special, irrespective of structure or function. during the evolution of the picornaviridae family, the 2a protein has been highly non-conserved. we believe that the 2a protein in this family can be classified into at least five distinct types according to previous studies. these five types are (a) chymotrypsin-like 2a, (b) parechovirus-like 2a, (c) hepatitis-a-virus-like 2a, (d) aphthovirus-l ... | 2017 | 28785248 |
| a waterborne outbreak involving hepatitis a virus genotype ia at a residential facility in the republic of korea in 2015. | hepatitis a virus (hav), a major cause of acute hepatitis, has had the highest occurrence among group 1 nationally notifiable infectious diseases in korea since 2010.recently,the annual increase in the hav infection rate among young adults has become a public health concern. | 2017 | 28759774 |
| ongoing hepatitis a among men who have sex with men (msm) linked to outbreaks in europe in tel aviv area, israel, december 2016 - june 2017. | between december 2016 and june 2017, 19 hepatitis a virus (hav)-positive cases, 17 of which were among men who have sex with men (msm) were identified in the tel aviv area. seven of the 15 sewage samples collected between january and june 2017 were also hav-positive. all sequences clustered with two of the three strains identified in the current european hav outbreak. we demonstrate that despite an efficient vaccination programme, hav can still be transmitted to an unvaccinated high-risk populat ... | 2017 | 28749336 |
| cytotoxic effect of co-expression of human hepatitis a virus 3c protease and bifunctional suicide protein fcu1 genes in a bicistronic vector. | recent reports on various cancer models demonstrate a great potential of cytosine deaminase/5-fluorocytosine suicide system in cancer therapy. however, this approach has limited success and its application to patients has not reached the desirable clinical significance. accordingly, the improvement of this suicide system is an actively developing trend in gene therapy. the purpose of this study was to explore the cytotoxic effect observed after co-expression of hepatitis a virus 3c protease (3c) ... | 2017 | 28748410 |
| cxcl10 is produced in hepatitis a virus-infected cells in an irf3-dependent but ifn-independent manner. | acute hepatitis a caused by hepatitis a virus (hav) infection is accompanied by severe liver injury in adult patients, and the liver injury is associated with the production of chemokines. herein, we investigated the mechanism of how hav infection induces the production of cxcr3 and ccr5 chemokines, such as cxcl10, ccl4 and ccl5. the production of cxcl10, ccl4 and ccl5 was markedly increased by hav (hm-175/18f) infection in the culture of primary human hepatocytes and hepg2 cells. in particular, ... | 2017 | 28744018 |
| development of a chemiluminescent dna fibre optic genosensor to hepatitis a virus (hav). | hepatitis a virus (hav) infection has caused substantial morbidity and economic losses to human society, presenting a major public health problem in many parts of the world. despite the capability for low-concentration detection, current pcr-based techniques are limited by the requirement of specialized lab equipment, trained personnel and a relatively large time-commitment. the need for a prompt in-field quantitative identification of hav in real samples has led us to develop a chemiluminescent ... | 2017 | 28738599 |
| compliance with vaccination against hepatitis a virus in germany: a retrospective analysis . | to analyze compliance with vaccination against hepatitis a virus (hav) in patients followed in general and pediatric practices in germany. | 2017 | 28737126 |
| thermal processing of live bivalve molluscs for controlling viruses: on the need for a risk-based design. | norovirus (nov) and hepatitis a virus (hav) are the most important viral hazards associated with human illness following consumption of contaminated bivalve molluscs. the effectiveness of the current eu criteria for heat processing of bivalve molluscs (i.e. raising the temperature of the internal mollusc flesh to at least 90°c for a minimum of 90 seconds) was evaluated using predictive microbiology. a hav thermal inactivation model was developed based on literature data in mollusc matrices durin ... | 2017 | 28723228 |
| immunogenicity and safety of the inactivated hepatitis a vaccine in children with juvenile idiopathic arthritis on methotrexate treatment: a matched case-control study. | to describe the immunogenicity and side effects of immunisation against hepatitis a virus (hav) in jia patients on methotrexate treatment, who have not been previously exposed to hav. | 2017 | 28721859 |
| hepatitis a virus genotypes and strains from an endemic area of europe, bulgaria 2012-2014. | hepatitis a virus (hav) infection is endemic in eastern european and balkan region countries. in 2012, bulgaria showed the highest rate (67.13 cases per 100,000) in europe. nevertheless, hav genotypes and strains circulating in this country have never been described. the present study reports the molecular characterization of hav from 105 patients from bulgaria. | 2017 | 28705178 |
| [immune response to one booster dose of inactivated hepatitis a vaccine in college students]. | objective: to evaluate the safety and immunogenicity of one booster dose of inactivated hepatitis a vaccine in young adults. methods: the subjects were selected from participants in the clinical trial of immunogenicity of inactivated and attenuated live hepatitis a vaccine in young adults. eligible subjects were those who had received one dose of inactivated or attenuated hepatitis a vaccine, could be contacted and were sero-negative before primary vaccination. all qualified subjects were immuni ... | 2017 | 28651399 |
| improving efficiency of viability-qpcr for selective detection of infectious hav in food and water samples. | to improve the efficacy of intercalating dyes to distinguishing between infectious and inactivated hepatitis a virus (hav) in food. | 2017 | 28649706 |
| antibodies against immune checkpoint molecules restore functions of tumor-infiltrating t cells in hepatocellular carcinomas. | ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (pd-1) and cytotoxic t-lymphocyte associated protein 4 (ctla4), downregulates the t-cell-mediated immune response (called immune checkpoints). antibodies that block these receptors increase anti-tumor immunity in patients with melanoma, non-small cell lung cancer, and renal cell cancer. tumor-infiltrating cd4(+) and cd8(+) t cells in patients with hepatocellular carcinoma (hcc) have been found to be functiona ... | 2017 | 28648905 |
| seroprevalence and susceptibility to hepatitis a in the european union and european economic area: a systematic review. | most of the european union (eu) and european economic area (eea) is considered a region of very low hepatitis a virus (hav) endemicity; however, geographical differences exist. we did a systematic review with the aim of describing seroprevalence and susceptibility in the general population or special groups in the eu and eea. we searched databases and public health national institutes websites for hav seroprevalence records published between jan 1, 1975, and june 30, 2014, with no language restr ... | 2017 | 28645862 |
| hepatitis a virus strains circulating during 1997-2015 in campania, a southern italy region with periodic outbreaks. | in italy, the incidence of hepatitis a has progressively declined over the last 30 years, though not homogeneously throughout the country. in campania, southern italy, high annual incidence rates have been reported and several periodic outbreaks have occurred. to investigate the phylogenetic and epidemiologic relationships among hav strains circulating in campania over the period 1997-2015, 87 hepatitis a cases were investigated. the most frequent risk factor was the consumption of raw/undercook ... | 2017 | 28621437 |
| hepatitis a virus infection and hepatitis a vaccination in human immunodeficiency virus-positive patients: a review. | hepatitis a virus (hav) is one of the most common infectious etiologies of acute hepatitis worldwide. the virus is known to be transmitted fecal-orally, resulting in symptoms ranging from asymptomatic infection to fulminant hepatitis. hav can also be transmitted through oral-anal sex. residents from regions of low endemicity for hav infection often remain susceptible in their adulthood. therefore, clustered hav infections or outbreaks of acute hepatitis a among men who have sex with men and inje ... | 2017 | 28611512 |
| the financial burden of public health responses to hepatitis a cases among food handlers, 2012-2014. | when food handlers become ill with hepatitis a virus (hav) infection, state and local health departments must assess the risk of hav transmission through prepared food and recommend or provide postexposure prophylaxis (pep) for those at risk for hav infection. providing pep (eg, hepatitis a [hepa] vaccine or immunoglobulin), however, is costly. to describe the burden of these responses on state and local health departments, we determined the number of public health responses to hav infections am ... | 2017 | 28609202 |
| unconventional secretion of hepatitis a virus. | 2017 | 28607085 | |
| [prevalence of hepatitis a antibody among population covered by different hepatitis a immunization strategies in shandong province, 2015, china]. | objective: to evaluate prevalence of hepatitis a antibody (anti-hav igg) among population covered by different hepatitis a vaccine immunization strategies in shandong province in 2015. methods: in october 2015, according to the geographical location of shandong province, the stratified random sampling method was used to stratify the 17 municipal distrcts, and the random number table method was used for sampling, first, two eastern cites (qingdao, rizhao), two western cities (liaocheng, zaozhuang ... | 2017 | 28592089 |
| glucose-regulated protein 78 is an antiviral against hepatitis a virus replication. | infection with hepatitis a virus (hav) is a major cause of acute hepatitis globally and it is important to identify the mechanisms of hav replication. glucose-regulated protein 78 (grp78) is an endoplasmic reticulum (er) chaperone and serves a role in unfolded protein response pathways. previous studies have demonstrated that grp78 functions as an endogenous antiviral factor. in the present study, two loss-of-function studies using grp78 were completed to elucidate the role of grp78 in hav infec ... | 2017 | 28587404 |
| effect of green tea extract on enteric viruses and its application as natural sanitizer. | in this work, the effect of green tea extract (gte) was assessed against murine norovirus (mnv) and hepatitis a virus (hav) at different temperatures, exposure times and ph conditions. initially, gte at 0.5 and 5 mg/ml were individually mixed with each virus at 5 log tcid50/ml and incubated 2 h at 37 °c at different phs (from 5.5 to 8.5). gte affected both viruses depending on ph with higher reductions observed in alkaline conditions. secondly, different concentrations of gte (0.5 and 5 mg/ml) w ... | 2017 | 28576363 |
| viral hepatitis a, active component, u.s. armed forces, 2007-2016. | during 2007-2016, there were 237 incident diagnoses of acute hepatitis a, with an overall incidence rate of 1.88 cases per 100,000 person-years (p-yrs). crude overall rates of hepatitis a were highest among service members in the youngest age group, those in healthcare occupations, and among air force and navy members. service members of "other" or unknown race/ethnicity and non-hispanic black service members had higher overall incidence rates of hepatitis a, compared to their non-hispanic white ... | 2017 | 28570087 |
| hepatitis a outbreaks in european homosexual men. | hepatitis a virus (hav) is a small rna, non-enveloped agent predominantly transmitted via the fecal/oral route through person-to-person contact or contaminated food and water. the mean incubation period is 28 days (range: 15-50). acute hepatitis a is always self-limited and very rarely fatal. moreover, it never progresses to chronicity. acutely infected persons are most likely to transmit hav before the onset of jaundice, when viral particle concentration in stool is highest. | 2017 | 28534888 |
| assessing activity of hepatitis a virus 3c protease using a cyclized luciferase-based biosensor. | hepatitis a is an acute infection caused by hepatitis a virus (hav), which is widely distributed throughout the world. the hav 3c cysteine protease (3c(pro)), an important nonstructural protein, is responsible for most cleavage within the viral polyprotein and is critical for the processes of viral replication. our group has previously demonstrated that hav 3c(pro) cleaves human nf-κb essential modulator (nemo), a kinase required in interferon signaling. based on this finding, we generated four ... | 2017 | 28501618 |
| seroprevalence of hepatitis a 12-years following the implementation of toddlers' vaccination: a population based study in israel. | in 1999, israel became the first country to introduce an inactivated hepatitis a vaccine into its national childhood vaccination program. the objective of the present study was to evaluate the seroprevalence of hepatitis a virus (hav) antibodies in the israeli population before and after the introduction of the program. | 2017 | 28498301 |
| protein composition of the hepatitis a virus quasi-envelope. | the picornaviridae are a diverse family of rna viruses including many pathogens of medical and veterinary importance. classically considered "nonenveloped," recent studies show that some picornaviruses, notably hepatitis a virus (hav; genus hepatovirus) and some members of the enterovirus genus, are released from cells nonlytically in membranous vesicles. to better understand the biogenesis of quasi-enveloped hav (ehav) virions, we conducted a quantitative proteomics analysis of ehav purified fr ... | 2017 | 28490497 |
| modeling the hepatitis a epidemiological transition in brazil and mexico. | many low- to middle-income countries have completed or are in the process of transitioning from high or intermediate to low endemicity for hepatitis a virus (hav). because the risk of severe hepatitis a disease increases with age at infection, decreased incidence that leaves older children and adults susceptible to hav infection may actually increase the population-level burden of disease from hav. mathematical models can be helpful for projecting future epidemiological profiles for hav. | 2017 | 28481680 |
| hepatitis a virus cellular receptor 2 (havcr2) is decreased with viral infection and regulates pro-labour mediators oa. | intrauterine infection caused by viral infection has been implicated to contribute to preterm birth. hepatitis a virus cellular receptor 2 (havcr2) regulates inflammation in non-gestational tissues in response to viral infection. | 2017 | 28466996 |
| occurrence and trend of hepatitis a virus in bivalve molluscs production areas following a contamination event. | the aim of this study was to assess the trend of hepatitis a virus (hav) in a coastal zone impacted by a contamination event, providing data for the development of management strategies. a total of 352 samples, including four bivalve mollusc species (mytilus galloprovincialis, solen vagina, venus gallina and donax trunculus), were taken over a period of 6 months from 27 production areas of the coast and analysis were performed according to iso/ts 15216-1:2013. hav presence was detected in 77 sam ... | 2017 | 28452010 |
| detection of potential infectious enteric viruses in fresh produce by (rt)-qpcr preceded by nuclease treatment. | foodborne illnesses associated with contaminated fresh produce are a common public health problem and there is an upward trend of outbreaks caused by enteric viruses, especially human noroviruses (hnovs) and hepatitis a virus (hav). this study aimed to assess the use of dnase and rnase coupled to qpcr and rt-qpcr, respectively, to detect intact particles of human adenoviruses (hadvs), hnov gi and gii and hav in fresh produce. different concentrations of dnase and rnase were tested to optimize th ... | 2017 | 28452009 |
| hepatitis a virus infections and outbreaks in asylum seekers arriving to germany, september 2015 to march 2016. | from september 2015 to march 2016, hepatitis a notifications in germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. children aged five to nine years were predominantly affected (22% of all cases in this period). we hypothesized that this increase could be explained by the marked influx of asylum seekers in this time period. we analysed national surveillance data and estimated the number of imported and autochthonous hepatitis a cases in asylum see ... | 2017 | 28442750 |
| improved detection of norovirus and hepatitis a virus in surface water by applying pre-pcr processing. | quantitative reverse transcriptase polymerase chain reaction (rt-qpcr) detection of waterborne rna viruses generally requires concentration of large water volumes due to low virus levels. a common approach is to use dead-end ultrafiltration followed by precipitation with polyethylene glycol. however, this procedure often leads to the co-concentration of pcr inhibitors that impairs the limit of detection and causes false-negative results. here, we applied the concept of pre-pcr processing to opti ... | 2017 | 28401478 |
| hepatitis e virus persists in the presence of a type iii interferon response. | the rig-i-like rna helicase (rlr)-mediated interferon (ifn) response plays a pivotal role in the hepatic antiviral immunity. the hepatitis a virus (hav) and the hepatitis c virus (hcv) counter this response by encoding a viral protease that cleaves the mitochondria antiviral signaling protein (mavs), a common signaling adaptor for rlrs. however, a third hepatotropic rna virus, the hepatitis e virus (hev), does not appear to encode a functional protease yet persists in infected cells. we investig ... | 2017 | 28558073 |
| distinct changing profiles of hepatitis a and e virus infection among patients with acute hepatitis in mongolia: the first report of the full genome sequence of a novel genotype 1 hepatitis e virus strain. | in january 2012, mongolia started a hepatitis a vaccination program, which has not yet been evaluated. the first occurrence of autochthonous acute hepatitis e in 2013, caused by genotype 4 hepatitis e virus (hev), suggests the need for a routine study to monitor its prevalence. one hundred fifty-four consecutive patients who were clinically diagnosed with acute hepatitis between 2014 and 2015 in ulaanbaatar, mongolia were studied. by serological and molecular testing followed by sequencing and p ... | 2017 | 28776712 |
| cytokine signatures discriminate highly frequent acute hepatitis a virus and hepatitis e virus coinfections from monoinfections in mexican pediatric patients. | the frequency of hepatitis a virus and hepatitis e virus infections and their cytokine profiles were analyzed in mexican pediatric patients with acute hepatitis. a high frequency of coinfections was found. significant overexpression of interleukin (il)-4, il-12, il-13 and interferon-gamma during hepatitis a virus monoinfections and limited secretion of cytokines in hepatitis e virus infections were observed. | 2017 | 28604562 |
| acute hepatitis a infection after hepatitis a immunity in a hiv-positive individual. | hepatitis a is a self-limiting infection caused by the hepatitis a virus (hav), transmitted predominantly by the faecal-oral route including some sexual practices. outbreaks are commonly reported in the men who have sex with men (population. previous exposure is thought to provide life-long immunity against subsequent infections with the development of an hav igg response. this paper reports a case of acute hepatitis a infection, despite evidence of a previously positive hepatitis a igg results ... | 2017 | 28860200 |
| fatal acute hepatic failure in a family infected with the hepatitis a virus subgenotype ib: a case report. | hepatitis a viral infection is a well-known cause of subclinical or acute self-limited hepatitis. few cases of hepatitis a virus (hav)-associated acute liver failure (alf) have been reported in low hav endemic countries annually. | 2017 | 28858094 |
| enzymatic and viability rt-qpcr assays for evaluation of enterovirus, hepatitis a virus and norovirus inactivation. implications for public health risk assessment. | to assess the potential of a viability dye and an enzymatic rt-qpcr pretreatment to discriminate between infectious and non-infectious enteric viruses. | 2017 | 28833965 |
| cellular cap-binding protein, eif4e, promotes picornavirus genome restructuring and translation. | picornaviruses use internal ribosome entry sites (iress) to translate their genomes into protein. a typical feature of these iress is their ability to bind directly to the eukaryotic initiation factor (eif) 4g component of the eif4f cap-binding complex. remarkably, the hepatitis a virus (hav) ires requires eif4e for its translation, but no mechanism has been proposed to explain this. here we demonstrate that eif4e regulates hav ires-mediated translation by two distinct mechanisms. first, eif4e b ... | 2017 | 28827335 |
| spatial and temporal distribution of norovirus and e. coli in sydney rock oysters following a sewage overflow into an estuary. | this paper reports a study of norovirus (nov) gii distribution and persistence in sydney rock oysters (sro) (saccostrea glomerata) located in an estuary after a pump station sewage overflow. sro were strategically placed at six sites spanning the length of the estuary from the pump station to the sea. the spatial and temporal distribution of nov, hepatitis a virus (hav) and escherichia coli (e. coli) in oysters was mapped after the contamination event. nov gi and gii, hav and e. coli were quanti ... | 2017 | 28685229 |
| development of a peptide elisa to discriminate vaccine-induced immunity from natural infection of hepatitis a virus in a phase iv study. | hepatitis a virus (hav) is a highly infectious agent that causes acute liver disease. the infection can trigger the production of antibodies against the structural and non-structural proteins of hav. nonetheless, vaccination with an hav vaccine leads to the production of a primary antibody against the structural proteins. because the non-structural proteins are only produced during active virus replication, there is no or very little antibody production against the non-structural proteins. howev ... | 2017 | 28631170 |
| mortality from selected diseases that can be transmitted by water - united states, 2003-2009. | diseases spread by water are caused by fecal-oral, contact, inhalation, or other routes, resulting in illnesses affecting multiple body systems. we selected 13 pathogens or syndromes implicated in waterborne disease outbreaks or other well-documented waterborne transmission (acute otitis externa, campylobacter, cryptosporidium, escherichia coli (e. coli), free-living ameba, giardia, hepatitis a virus, legionella (legionnaires' disease), nontuberculous mycobacteria (ntm), pseudomonas-related pneu ... | 2017 | 28598348 |
| enteric viruses and fecal bacteria indicators to assess groundwater quality and suitability for irrigation. | according to italian ministerial decree no. 185 of 12 june 2003, water is considered suitable for irrigation if levels of fecal bacteria (i.e., escherichia coli and salmonella) are within certain parameters. the detection of other microorganisms is not required. the aim of this study is to determine the bacteriological quality of groundwater used for irrigation and the occurrence of enteric viruses (norovirus, enterovirus, rotavirus, hepatovirus a), and to compare the presence of viruses with th ... | 2017 | 28538682 |
| bacteriophages as enteric viral indicators in bivalve mollusc management. | human enteric viruses, such as norovirus and hepatitis a virus, are spread by a variety of routes including faecal-oral transmission. contaminated bivalve shellfish are regularly implicated in foodborne viral disease outbreaks internationally. traditionally indicator bacteria, the coliforms and escherichia coli, have been used to detect faecal pollution in growing waters and shellfish. however, studies have established that they are inadequate as indicators of the risk of human enteric viruses. ... | 2017 | 28400015 |
| viral hepatitis screening in transgender patients undergoing gender identity hormonal therapy. | viral hepatitis is a global health issue and can lead to cirrhosis, liver failure, and hepatocellular carcinoma. guidelines for viral hepatitis screening in the transgender population do not exist. transgender patients may be at higher risk for contracting viral hepatitis due to socioeconomic and behavioral factors. the aim of this study was to measure the quality of screening, prevalence, and susceptibility of viral hepatitis, and to identify barriers to screening in transgender patients underg ... | 2017 | 28857896 |
| programmed cell death 1 (pd-1) and cytotoxic t lymphocyte-associated antigen 4 (ctla-4) in viral hepatitis. | virus-specific cluster of differentiation 8 (cd8+) cytotoxic t cells (ctl) recognize viral antigens presented on major histocompatibility complex (mhc) class i chains on infected hepatocytes, with help from cd4+ t cells. however, this ctl response is frequently weak or undetectable in patients with chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infection. programmed cell death 1 (pd-1) and cytotoxic t lymphocyte-associated antigen 4 (ctla-4) are receptors in the cd28 family of costi ... | 2017 | 28703774 |
| pityriasis rosea in a patient with retrovirus infection and a history of syphilis and positive results of infection with hepatitis a virus, hepatitis b virus and hepatitis c virus. | 2017 | 28670260 | |
| hepatitis e virus induced acute liver failure with scrub typhus coinfection in a pregnant woman. | coinfections contribute significantly to diagnostic challenges of acute febrile illnesses, especially in endemic areas. the confusion caused by overlapping clinical features impedes timely management. herein, we report an unusual, previously unreported case of a pregnant woman suffering from a coinfection of scrub typhus and hepatitis e virus. a 25-year-old, 31-week pregnant woman presented with jaundice for 5 days and altered sensorium for 2 days. she had features of both viral acute liver fail ... | 2017 | 28663682 |
| acute hepatitis a, b and c but not d is still prevalent in mongolia: a time trend analysis. | mongolia has one of the highest hepatitis a, c, b and d infection incidences worldwide. we sought to investigate changes in the proportion of acute viral hepatitis types in mongolia over the last decade. | 2017 | 28535669 |
| atypical clinical manifestations of hepatitis a among children aged 1-16 years in south-eastern region of turkey. | hepatitis a virus (hav) infection has several atypical manifestations, including fulminant hepatitis, relapsing hepatitis, prolonged cholestasis and extrahepatic manifestations. in this study, we aimed to describe the characteristics and outcomes of the pediatric patients with atypical manifestations of hav infection. four hundred twelve children with symptomatic hepatitis a infection admitted to gaziantep children's hospital department of pediatric infectious disease between august 2011 and jan ... | 2017 | 27186695 |
| a virus resonance light scattering sensor based on mussel-inspired molecularly imprinted polymers for high sensitive and high selective detection of hepatitis a virus. | we described a novel resonance light scattering (rls) sensor for the specific recognition of trace quantities of hepatitis a virus (hav); the sensor was based on a mussel-inspired hepatitis molecularly imprinted polymer. as a recognition element, polydopamine (pda)-coated totivirus-imprinted polymer was introduced on the surface of sio2 nanoparticles (virus-imprinted sio2@pda nps) using an efficient one-step synthesis method. the target virus was selectively captured by the imprinted polymer fil ... | 2017 | 27631682 |