Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| screening for oral cancer. | the incidence of oral cancer appears to be increasing, especially in younger patients. risk factors include use of tobacco and alcohol, and exposure to human papillomavirus. vizilite plus (zila pharmaceuticals) is a combination device that uses fluorescent light and toluidine blue tissue staining to help dentists identify abnormal changes in the mucous membranes of the oral cavity. originally developed for detecting abnormal growths on the uterine cervix, in 2001 it received fda clearance for "i ... | 2009 | 19229163 |
| ifng (+874 t/a) polymorphism and cervical intraepithelial neoplasia in brazilian women. | our objective was to investigate the relationship between ifng (+874 t/a) polymorphism and cervical intraepithelial neoplasia (cin) in a population of brazilian women. ninety-six women, cin ii (48) and cin iii (48) and 50 normal controls, were enrolled in this study. dna was extracted from blood samples by the salting out method and polymerase chain reaction (pcr) amplified. ifng genotyping was performed by the pcr-sequence specific primer method, using the cytokine genotyping tray. there were n ... | 2009 | 19232001 |
| cervical infections by multiple human papillomavirus (hpv) genotypes: prevalence and impact on the risk of precancerous epithelial lesions. | a large proportion of human papillomavirus (hpv) infections is sustained by multiple genotypes. the effect of multiple infections on the risk of cervical intraepithelial neoplasia (cin) and the potential efficacy of vaccine on these infections are controversial. we performed viral typing by sfp(10)-lipa on a consecutive series of 1,323 women undergoing colposcopy, 69% of whom had cervical biopsy, and correlated cin severity with the type and number of hpvs. overall prevalence of hpv-dna was 68.9 ... | 2009 | 19235847 |
| quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development. | human papillomavirus (hpv) rna levels may be a more sensitive early indicator of predisposition to carcinogenesis than dna levels. we evaluated whether levels of hpv-16 and hpv-18 dna and messenger rna (mrna) in newly detected infections are associated with cervical lesion development. female university students were recruited from 1990 to 2004. cervical samples for hpv dna, hpv mrna, and papanicolaou testing were collected tri-annually, and women were referred for colposcopically directed biops ... | 2009 | 19235870 |
| molecular detection and genotyping of human papillomavirus in cervical carcinoma biopsies in an area of high incidence of cancer from moroccan women. | cervical cancer is a leading cause of cancer-related deaths in developing countries, and the human papillomavirus (hpv) is linked etiologically to cervical cancer. eighty nine cervical carcinoma biopsies collected from women visiting the oncologic center in casablanca (centre hospitalier universitaire ibn rochd, morocco) for cervical cancer symptoms, were screened for hpv dna by polymerase chain reaction amplification with subsequent typing by hybridization with specific oligonucleotides for hpv ... | 2009 | 19235879 |
| human papillomavirus (hpv) vaccines: limited cross-protection against additional hpv types. | 2009 | 19236278 | |
| comparing knowledge and perceived risk related to the human papilloma virus among australian women of diverse sexual orientations. | the study compared levels of awareness of human papilloma virus (hpv) as a sexually transmissible infection (sti) between women of different sexual orientations. it also examined self-reported risk factors for hpv infection, perceived level of personal risk, and willingness to have the hpv vaccine. | 2009 | 19236366 |
| vulval intraepithelial neoplasia with mucinous differentiation: report of 2 cases of a hitherto undescribed phenomenon. | we report 2 cases of classic vulval intraepithelial neoplasia (vin) with collections of cells throughout the full epithelial thickness and within epithelial downgrowths containing intracytoplasmic mucin. the mucinous cells were bland with eccentrically placed small regular nuclei and were positive with cam5.2, carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 7, markers that are typically positive in the neoplastic cells of paget disease. both cases were strongly positive wi ... | 2009 | 19238078 |
| school nurses' workloads: how should they be prioritised? | the school nurse role has developed considerably over the past two decades in order to meet the changing health needs of the school-age population. changes demand continuous adaptability to prioritise workload pressures, one example of which is the new vaccination programme against human papillomavirus. this paper examines the wider context in which school health care is delivered and proposes a systematic, evidence-based approach that school nurse managers could take toward prioritising tasks. ... | 2009 | 19238818 |
| prevalence, clearance, and incidence of anal human papillomavirus infection in hiv-infected men: the hipvirg cohort study. | human immunodeficiency virus (hiv)-seropositive men who have sex with men (msm) are at higher risk of human papillomavirus (hpv) infection. this study was conducted to better understand the natural history of type-specific hpv infection in the anus. | 2009 | 19239366 |
| proteomic analysis reveals the actin cytoskeleton as cellular target for the human papillomavirus type 8. | recent studies strongly support a role of human papillomavirus type 8 (hpv8) in non-melanoma skin cancer development. in this study, a quantitative two-dimensional (2d) differential gene expression (dige) gel approach combined with mass spectrometry has been used to identify proteins that are abundantly deregulated in primary human epidermal keratinocytes expressing hpv8 sequences. twenty six protein spots showed significant changes in the level of expression between keratinocytes expressing e7 ... | 2009 | 19243805 |
| determinants of stability for the e6 protein of papillomavirus type 16. | e6 is an oncoprotein produced by human papillomavirus (hpv). the e6 protein from high-risk hpv type 16 contains two zinc-binding domains with two c-x-x-c motifs each. e6 exerts its transforming functions through formation of a complex with e6ap, which binds p53 and stimulates its degradation. there have been few biophysical and structural studies due to difficulty in preparation of soluble protein; here we describe the preparation of soluble e6 constructs including the two separated zinc-binding ... | 2009 | 19244625 |
| currents in contemporary ethics: hpv vaccines, privacy, and public health. | 2009 | 19245609 | |
| molecular targets for cancer chemoprevention. | vaccines targeting infections with hepatitis b virus, a risk factor for hepatocellular cancer, and human papillomavirus, a risk factor for cervical cancer, are considered major clinical cancer chemoprevention successes. molecularly targeted agents can prevent breast cancer (raloxifene and tamoxifen), colorectal adenomas (celecoxib), and prostate cancer (finasteride). nevertheless, the broad translation of chemoprevention to the clinic is not yet a reality. continuing research of molecular target ... | 2009 | 19247304 |
| epidemiological data of different human papillomavirus genotypes in cervical specimens of hiv-1-infected women without history of cervical pathology. | to study the epidemiology of different human papillomavirus (hpv) genotypes in cervical samples of hiv-1-infected women with normal papanicolau smears. | 2009 | 19131892 |
| single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous sccs. | cutaneous squamous cell carcinomas (csccs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cscc tumorigenesis remain poorly defined. we have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 csccs using paired non-tumor samples. the most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, res ... | 2009 | 19131950 |
| expression of human papilloma virus type 16 e5 protein in amelanotic melanoma cells regulates endo-cellular ph and restores tyrosinase activity. | melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. in tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal ph. the e5 oncogene of the human papillomavirus type 16 is a small transmembrane protein with a weak transforming activity and a role during the early steps of viral infections. e5 has been shown to interact with 16 kda subunit c of the trans-membrane vacuolar atpase proton pump ultimately r ... | 2009 | 19133143 |
| palliative aspects of recurrent respiratory papillomatosis. | recurrent respiratory papillomatosis (rrp) is a chronic, frequently debilitating, and potentially life-threatening disease. therapy for rrp has evolved from simply inserting a tracheotomy to provide an airway and plucking out papillomata with cup forceps to provide some degree of voice to the present-day far more sophisticated approaches, along with preventative measures that may someday offer the potential dramatically to decrease disease prevalence. family dynamics and support and intentional ... | 2009 | 19134490 |
| enhancement of dendritic cell-based vaccine potency by anti-apoptotic sirnas targeting key pro-apoptotic proteins in cytotoxic cd8(+) t cell-mediated cell death. | dendritic cells (dcs) have become an important measure for the treatment of malignancies. current dc preparations, however, generate short-lived dcs because they are subject to cell death from various apoptotic pressures. antigen-specific cd8(+) cytotoxic t lymphocytes (ctls) is one of the main obstacles to limit the dc-mediated immune priming since ctls can recognize the target antigen expressing dcs as target cells and kill the dcs. ctls secret perforin and serine protease granzymes during ctl ... | 2009 | 19135479 |
| antibody response for l1, e6, e7 hpv 16, and hpv 18 antigens in tunisian women with cervical cancer. | results obtained in the present work indicated that the luminex assay is more sensitive than elisa. the reactivity to the early antigens e6 and e7 was 37% versus 42% for hpv 16 and 21% versus 20% for hpv 18 among cervical cancer cases using elisa. however, these ratios were 44% and 61%, respectively, for e6 and e7 hpv 16 versus 28% and 21% for e6 and e7 hpv 18 when using the luminex technique. data also indicated that hpv 16 and hpv 18 showed distinct profiles for the different antigens tested. ... | 2009 | 19117204 |
| prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in belgium. | before the introduction of vaccination against human papillomaviruses (hpv) as a new strategy of combating cervical cancer, it is required to describe the baseline prevalence of hpv infection as well as the distribution of the different hpv types in the population and among women with cervical lesions. | 2009 | 19124515 |
| variables associated with human papillomavirus (hpv) vaccine acceptance by men. | to determine correlates of human papillomavirus (hpv) vaccine acceptance for men. | 2009 | 19124631 |
| detection of human papillomavirus dna in retinoblastoma samples: a preliminary study. | recent studies have shown the presence of human papillomavirus (hpv) genome in retinoblastoma (rb) tumor samples. there is no information on the hpv status in the rb tumors of indian patients. we studied the presence of hpv genome in rb tumor samples from patients with unilateral tumor. forty-four fresh rb tumor samples and 30 non-neoplastic donor retinas were analyzed for the presence of hpv 16 and 18 genome by nested and seminested polymerase chain reaction. tumor tissue sections were also use ... | 2009 | 19125079 |
| an hpv 16 l1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic t-cell activity in mice. | even though two prophylactic vaccines against hpv are currently licensed, infections by the virus continue to be a major health problem mainly in developing countries. the cost of the vaccines limits wide-scale application in poor countries. a promising strategy for producing affordable and efficient vaccines involves the expression of recombinant immunogens in plants. several hpv genes have been expressed in plants, including l1, which can self-assemble into virus-like particles. a plant-based, ... | 2009 | 19126233 |
| determinants of incidence of primary fallopian tube carcinoma (pftc). | primary fallopian tube carcinoma (pftc) is a rare malignancy, but its incidence has been rising during the last decades and varies between 2.9/1,000,000 and 5.7/1,000,000. the epidemiology of pftc has been sparsely studied. in finland, the incidence rate has been rising during the last decades. the rise has been highest in the cities, in higher social classes, and in certain specific occupations. parity gives protection against this disease, as does a previous sterilization procedure. earlier th ... | 2009 | 19107444 |
| typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypes. | human papillomavirus (hpv) are distributed widely and persistent infection with high-risk (hr) hpv is recognized as a necessary cause of cervical cancer. the aim of this study was to evaluate the distribution of different hr-hpv genotypes in 199 women with cervical pre-invasive lesions undergoing conservative treatment. a linear array hpv genotyping test was used to identify individual hpv genotypes in cervical samples. it was observed that the most prevalent hpv genotypes were hpv 16 (52.6%), h ... | 2009 | 19107962 |
| genomic diversity of human papillomavirus (hpv) genotype 38. | human papillomavirus (hpv) genotype hpv 38 is a hpv genotype associated with skin cancer and is classified taxonomically in the beta-pv genus-species 2. at least six genomic variants of hpv 38, including prototype isolate and its subtype fa125, have been characterized so far. in order to investigate further the genomic diversity of hpv 38, a total of 39 hpv 38 positive samples obtained from hairs plucked from pubic, scrotal, perianal or eyebrow regions from 31 immunocompetent healthy male indivi ... | 2009 | 19107968 |
| tax1bp1 interacts with papillomavirus e2 and regulates e2-dependent transcription and stability. | the papillomavirus e2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. from a yeast two-hybrid screen, we identified the cellular protein tax1bp1 as a novel binding partner of human papillomavirus type 18 (hpv18) e2. tax1bp1 also interacts with the hpv16 and bovine papillomavirus type 1 (bpv1) e2 proteins, with the c-terminal region of tax1bp1 interacting with the n-terminal transactivation domain of bpv1 e2. tax1b ... | 2009 | 19109394 |
| sequence variation of human papillomavirus type 16 and measurement of viral integration by quantitative pcr. | given that the integration of human papillomavirus type 16 (hpv16) into the host genome occurs preferentially with the disruption of the e2 gene, a ratio of e2 to e7 gene copies is often used as a marker for integration. it is largely undetermined, however, whether ratio estimates are affected by hpv intratypic variations. we assembled four plasmid constructs, each containing a dna fragment from an hpv16 european, asian-american, african-1, or african-2 variant. these constructs and nine cervica ... | 2009 | 19116350 |
| expression pattern and subcellular localization of human papillomavirus minor capsid protein l2. | the expression pattern of human papillomavirus (hpv) capsid antigen l2 is poorly described, and the significance of its localization with both promyelocytic leukemia protein (pml) and daxx in a subnuclear domain, nuclear domain 10 (nd-10), when ectopically expressed in tissue culture cells is controversial. to address whether nd-10 localization of l2 occurs in natural cervical lesions, we used a hpv16 and hpv18 l2-specific monoclonal antibody (rg-1), in addition to rabbit antiserum to hpv6 l2, t ... | 2009 | 19095951 |
| cervical cancer screening with liquid cytology in women with developmental disabilities. | to evaluate the use of liquid cytology in pap smears in women with developmental disabilities (dd) for endocervical cell yield and abnormalities, via speculum examination or blind technique. | 2009 | 19072727 |
| the role of male circumcision in the prevention of human papillomavirus and hiv infection. | 2009 | 19086812 | |
| human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. | the risk of head and neck squamous cell carcinoma (hnscc) associated with common human papillomavirus types has not been well defined. | 2009 | 19087986 |
| diminished ifn-gamma and il-10 and elevated foxp3 mrna expression in the cervix are associated with cin 2 or 3. | cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (hpv) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (cin). additionally, regulatory t (treg) cells are increasingly understood to be important modulators of cellular immunity. using quantitative rt-pcr, we measured, in cross-sectional design, the cervical mrna expression of ifn-gamma, il-10, and il-12, as ... | 2009 | 19089920 |
| prevalence of human papillomavirus and chlamydia trachomatis infection among women attending cervical cancer screening in the republic of korea. | cervical cancer screening with the conventional papanicolaou test is recommended for the women aged 30 years and more in korea. cervical infection with human papillomavirus (hpv) is the most important cause of cervical cancer and chlamydia trachomatis (ct) is the most common bacterial sexually transmitted infection and may also be associated with risk of cervical cancer. a cross-sectional study of women attending the national cervical cancer screening program in busan and suwon was carried out. ... | 2009 | 19077566 |
| the common mechanisms of transformation by the small dna tumor viruses: the inactivation of tumor suppressor gene products: p53. | the small dna tumor viruses, polyoma virus, simian vacuolating virus 40, the papilloma viruses and the human adenoviruses, were first described during a period of intense virus discovery (1930-1960s) and shown to produce tumors in animals. in each of these cases the viral dna was shown to persist (commonly integrated into a host chromosome) and only a selected portion of this dna was expressed as m-rna and proteins in these cancers. the viral encoded tumor antigens were identified and shown to b ... | 2009 | 19081592 |
| the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. | to investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. hpv-16 e6 and e7 genes were transfected into c33a and hfb to detect the profiling of angiogenesis-associated factors with the transignal angiogenesis antibody array. the mrna and protein levels of the cytokines were examined by traditional rt-pcr and western blotting in both cell lines before and after transfection of hpv-16 e6 and e7. hpv-16 e6 and e7 genes were ... | 2009 | 19082439 |
| prevalence of human papillomavirus types in cervical and oral cancers in central india. | cervical cancer that is associated with high-risk human papillomaviruses (hpv) is the most common malignancy in indian women. therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. however, relatively little is known about the prevalence of the different hpv types in cervical cancers in different regions of india, particularly central india. in this study, we have determined the hpv type distribution in 180 cervical cancers of women ... | 2009 | 19056450 |
| whim syndrome: congenital immune deficiency disease. | warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome is characterized by susceptibility to human papilloma virus infection-induced warts and carcinomas; neutropenia, b-cell lymphopenia and hypogammaglobulinema-related infections; and bone marrow myelokathexis (myeloid hyperplasia with apoptosis). the purpose of this report is to review new findings about whim. | 2009 | 19057201 |
| distribution and density of cd1a+ and cd83+ dendritic cells in hpv-associated laryngeal papillomas. | respiratory papillomatosis associated with human papilloma virus (hpv) infection is the most common benign laryngeal neoplasm. the age of patients at disease onset, hpv type, number of surgeries are well known prognostic factors of the disease course. the correlation between dendritic cell (dc) density in tumor tissue and clinical prognosis was established. | 2009 | 19062106 |
| self-collection of genital human papillomavirus specimens in heterosexual men. | we assessed the accuracy of self-collected human papillomavirus (hpv) specimens in men compared with clinician-collected specimens from men in british columbia and determined the prevalence of hpv subtypes at different male genital sites. | 2009 | 19066196 |
| p16 ink4a immunostaining identifies occult cin lesions in hpv-positive women. | to evaluate whether p16 staining could help to recognize underestimated cervical intraepithelial neoplasia (cin) in women positive for high-risk human papillomavirus (hr-hpv) with negative biopsy. out of 1,259 women undergoing a histologic study and a simultaneous hr-hpv detection using the hybrid capture 2 test, we selected all patients testing positive for hr-hpv and having a negative biopsy (n=139), as well as all women testing negative for hr-hpv with a biopsy of either cin 1 (26 cases) or c ... | 2009 | 19047902 |
| anal intraepithelial neoplasia in a multisite study of hiv-infected and high-risk hiv-uninfected women. | to study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (hpv), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for hiv infection. | 2009 | 19050387 |
| prognostic significance of hpv physical status and integration sites in cervical cancer. | human papilloma virus (hpv) infection is the major cause of cervical cancer and integration of hpv dna into the host cell genome is believed to be essential for malignant transformation. mirnas are a class of 19-24 nt non-coding rnas that regulate gene expression primarily through post transcriptional repression or m-rna degradation in a sequence specific manner. the aim of this study was to determine the frequency of hpv16 and 18 integrated and episomal forms and to evaluate its prognostic sign ... | 2009 | 19640172 |
| epidemiologic natural history and clinical management of human papillomavirus (hpv) disease: a critical and systematic review of the literature in the development of an hpv dynamic transmission model. | natural history models of human papillomavirus (hpv) infection and disease have been used in a number of policy evaluations of technologies to prevent and screen for hpv disease (e.g., cervical cancer, anogenital warts), sometimes with wide variation in values for epidemiologic and clinical inputs. the objectives of this study are to: (1) provide an updated critical and systematic review of the evidence base to support epidemiologic and clinical modeling of key hpv disease-related parameters in ... | 2009 | 19640281 |
| chimeric l1-l2 virus-like particles as potential broad-spectrum human papillomavirus vaccines. | the amino (n) terminus of the human papillomavirus (hpv) minor capsid protein l2 can induce low-titer, cross-neutralizing antibodies. the aim of this study was to improve immunogenicity of l2 peptides by surface display on highly ordered, self-assembled virus-like particles (vlp) of major capsid protein l1, and to more completely characterize neutralization epitopes of l2. overlapping peptides comprising amino acids (aa) 2 to 22 (hereafter, chimera or peptide 2-22), 13 to 107, 18 to 31, 17 to 36 ... | 2009 | 19640991 |
| racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients. | the burden of squamous cell carcinoma of the head and neck (scchn) is greater for blacks than for whites, especially in oropharyngeal cases. we previously showed retrospectively that disease-free survival was significantly greater in white than in black scchn patients treated with chemoradiation, the greatest difference occurring in the oropharyngeal subgroup. oropharyngeal cancer is increasing in incidence and in its association with human papillomavirus (hpv) infection; hpv-positive oropharyng ... | 2009 | 19641042 |
| down-regulation of grim-19 expression is associated with hyperactivation of stat3-induced gene expression and tumor growth in human cervical cancers. | cervical cancer is the most common malignant disease responsible for the deaths of a large number of women in the developing world. although certain strains of human papillomavirus (hpv) have been identified as the cause of this disease, events that lead to formation of malignant tumors are not fully clear. stat3 is a major oncogenic transcription factor involved in the development and progression of a number of human tumors. however, the mechanisms that result in loss of control over stat3 acti ... | 2009 | 19642906 |
| human papillomavirus genotyping using an automated film-based chip array. | the infiniti hpv-quad assay is a commercially available genotyping platform for human papillomavirus (hpv) that uses multiplex pcr, followed by automated processing for primer extension, hybridization, and detection. the analytical performance of the hpv-quad assay was evaluated using liquid cervical cytology specimens, and the results were compared with those results obtained using the digene high-risk hpv hc2 test (hc2). the specimen types included surepath and preservcyt transport media, as w ... | 2009 | 19644025 |
| obstetrician-gynecologists and the hpv vaccine: practice patterns, beliefs, and knowledge. | human papillomavirus (hpv), the most common sexually transmitted infection in the united states, can be contracted by young girls shortly after sexual debut. human papillomavirus can lead to cervical and anogenital cancers and genital warts. a vaccine has been developed to protect against precancerous lesions. we examined obstetrician-gynecologists' practices, opinions, and knowledge regarding this vaccine. | 2009 | 19646670 |
| principles and analytical performance of abbott realtime high risk hpv test. | abbott realtime high risk (hr) hpv is a new automated, qualitative real-time pcr test for detection of dna from 14 high-risk human papillomavirus (hpv) types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) in cervical specimens. the test can also differentiate between hpv 16, hpv 18 and non-hpv 16/18 types in a single reaction. objectives: this article describes the principles of assay design and the analytical performance of abbott realtime hr hpv. | 2009 | 19651363 |
| clinical performance of the aptima hpv assay for the detection of high-risk hpv and high-grade cervical lesions. | human papillomavirus (hpv) dna testing is widely used in conjunction with papanicolaou (pap) testing in cervical cancer screening programs to improve the detection of high-grade lesions. while hpv dna test sensitivity is good, an improvement in specificity is desired. detection of hpv mrna may improve specificity. the aptima hpv assay detects the mrna of 14 high-risk hpv types in liquid-based cytology specimens. | 2009 | 19651370 |
| a comparative review of laboratory-developed tests utilizing invader hpv analyte-specific reagents for the detection of high-risk human papillomavirus. | background: testing for human papillomavirus (hpv) has emerged as an important component of cervical cancer screening and disease management. analytic performance (sensitivity, specificity, positive predictive value, negative predictive value, accuracy) and clinical relevance are important criteria by which any new test must be reviewed. objective: this paper compares laboratory-developed tests, utilizing invader analyte-specific reagents (asrs) for the detection of oncogenic hpv dna, to the dig ... | 2009 | 19651372 |
| the clinical performance of invader technology and surepath when detecting the presence of high-risk hpv cervical infection. | testing for high-risk genotypes of the human papillomavirus (hr hpv) has been fully integrated into the management algorithms for the prevention of cervical cancer. the literature is limited with regard to the evaluation of the clinical performance of laboratory-developed tests (ldt) utilizing invader v2.0 assay (thirdwave/hologic, madison, wi, usa) for the detection of hr hpv. | 2009 | 19651373 |
| commentary on statement on human papillomavirus test utilization. | 2009 | 19653706 | |
| people seeking health information about human papillomavirus via the internet have a very high level of anxiety. | a website with evidence-based information on human papillomavirus (hpv) has been developed at the university of antwerp, belgium. visitors were asked to fill in a web-based form, including the state-trait anxiety inventory (stai), to obtain information on their profile. during the study period, 232 of 3638 (6.4%) visitors filled in the form. in our study, people looking for hpv information on the internet showed high anxiety levels. three determinants contributed to the stai score: a previous hp ... | 2009 | 19653966 |
| ulbp6/raet1l is an additional human nkg2d ligand. | to date five ulbp/raet (ul16-binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2-q25.3, have been shown to encode ligands of the activating immunoreceptor nkg2d. here, we show that a sixth gene, ulbp6/raet1l, is a polymorphic locus that expresses a functional transcript. ulbp6 had a more restricted expression profile in cell lines and primary human tissues than other nkg2d ligands, but expression was detected in several human papillomavirus-po ... | 2009 | 19658097 |
| epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women. | two hpv vaccines prevent infection with hpv-16 and hpv-18, high-risk (cancer-associated) hpv types which together cause approximately 70% of cervical cancers; one vaccine also prevents hpv-6 and hpv-11, which together cause approximately 90% of anogenital warts. defining type-specific hpv epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. | 2009 | 19665924 |
| carbonic anhydrase ix and human papillomavirus as diagnostic biomarkers of cervical dysplasia/neoplasia in women with a cytologic diagnosis of atypical glandular cells: a gynecologic oncology group study in united states. | high-risk human papillomavirus (h-hpv) infection is strongly linked to cervical neoplasia, but its role in detecting glandular lesions (gls) is unclear. in the cervix, carbonic anhydrase ix (ca-ix) is expressed in cervical neoplasia, but rarely in the benign cervix. the diagnostic utility of these biomarkers was evaluated in women with a cytologic diagnosis of atypical glandular cells (agc). h-hpv was detected using hybrid capture 2 (hc2) in liquid-based cytology, and ca-ix immunoreactivity was ... | 2009 | 19670419 |
| no indications for hpv involvement in the hypertrophic skin lesions of a darier disease case without atp2a2 gene mutations. | darier disease (dd) is a relatively common genodermatosis characterized by impaired differentiation and abnormal cell-to-cell adhesion. haploinsufficiency of the atp2a2 gene product, sarco/endoplasmic reticulum ca(2+) atpase isoform 2 (serca2), is the underlying cause of most cases. although dd may have a papillomatous appearance, few and controversial results have been reported about the role of human papillomavirus (hpv) in this disease. the aim of this study was to determine a possible correl ... | 2009 | 19674205 |
| evaluation of a prototype real-time pcr assay for carcinogenic human papillomavirus (hpv) detection and simultaneous hpv genotype 16 (hpv16) and hpv18 genotyping. | results from a prototype real-time pcr assay that separately detected human papillomavirus genotype 16 (hpv16), hpv18, and 12 other carcinogenic hpv genotypes in aggregate (cobas 4800 hpv test) and results from a pcr assay that detects 37 hpv genotypes individually (linear array) were compared using a convenience sample of cervical specimens (n = 531). the percentage of total agreement between the two assays was 94.7% (95% confidence interval, 92.5 to 96.5%). the linear array test was more likel ... | 2009 | 19675214 |
| concurrent human papillomavirus-associated tonsillar carcinoma in 2 couples. | we describe 2 nonsmoking, nondrinking couples who developed human papillomavirus (hpv)-associated tonsillar cancer within 12 months of each other. after histopathologic evaluation, hpv l1, e2, e6, and lcr regions were amplified, and phylogenetic analysis of amplimers was determined. quantitative polymerase chain reaction targeting hpv-16/18 l1 and e7 regions and p16 immunohistochemistry were performed. tissues were hpv-16 positive, with distinct intercouple nucleotide differences and multiple un ... | 2009 | 19678755 |
| value of p16(ink4a) as a marker of progression/regression in cervical intraepithelial neoplasia grade 1. | the objective of this study was to evaluate the usefulness of p16(ink4a) staining to classify cervical intraepithelial neoplasia grade 1 according to its progression/regression risk. | 2009 | 19683687 |
| digene hpv genotyping rh test ruo: comparative evaluation with inno-lipa hpv genotyping extra test for detection of 18 high-risk and probable high-risk human papillomavirus genotypes. | standardized and validated methods for the specific detection and identification of a spectrum of high-risk (hr) hpv genotypes will be necessary if hpv genotyping gains an important role in the clinical management of hpv-related precancerous lesions and cancers. | 2009 | 19683958 |
| human papillomavirus genotype distributions inform screening and vaccination policy. | 2009 | 19684300 | |
| molecular mechanisms of human papillomavirus-induced carcinogenesis. | approximately 20% of all cancers are associated with infectious agents. among them, human papillomaviruses (hpvs) are very common and are now recognized as the etiological agent of cervical cancer, the second most common cancer in women worldwide, and they are increasingly linked with other forms of dysplasia. carcinogenesis is a complex and multistep process requiring the acquisition of several genetic and/or epigenetic alterations. hpv-induced neoplasia, however, is in part mediated by the int ... | 2009 | 19684440 |
| detection and typing of human papillomavirus nucleic acids in biological fluids. | human papillomaviruses (hpv) are the etiologic agents of cancer of the uterine cervix and several other neoplasias. detection of hpv infection will improve the sensitivity of primary and secondary screening of cervical cancer. the clinical indications for the use of hpv tests will have to consider the natural history of hpv infection and diseases, and the multiplicity of types involved. signal amplification hpv dna tests detect several high-risk hpv types, are standardized, commercially availabl ... | 2009 | 19684443 |
| from causality to prevention - the example of cervical cancer: my personal contribution to this fascinating history. | the history of the generation of an hypothesis linking human papillomavirus to cervical cancer, as well as a summary of the various molecular epidemiological studies undertaken to confirm such hypothesis are described. | 2009 | 19684449 |
| verrucous oral lesions: possibly not so innocuous after all. squamous papilloma. | 2009 | 19685649 | |
| effect of human papillomavirus on cell cycle-related proteins p16, ki-67, cyclin d1, p53, and proex c in precursor lesions of cervical carcinoma: a tissue microarray study. | in-depth study of cell cycle proteins and human papillomavirus (hpv) genotyping can provide useful information about the malignant potential of precursor lesions of cervical carcinoma (cc). immunostaining of cell cycle-related proteins (p16, cyclin d1, ki-67, p53, and proex c) was evaluated using tissue microarrays, and hpv genotypes were identified in 144 cervical tissue specimens encompassing normal or benign epithelial lesions, low- and high-grade squamous intraepithelial lesions (lsil and hs ... | 2009 | 19687314 |
| anal pap smears: should we be doing them? | to identify the need to perform anal papanicolau (pap) smears for diagnosing histologic changes associated with human papilloma virus (hpv) infection in order to provide early intervention for the prevention of anal cancer. to offer the primary care provider information, based on evidence-based research, about identifying the high-risk patient using risk factors, instructions on performing the anal pap smear, interpreting the results, and initiating treatment interventions and/or referrals for c ... | 2009 | 19689440 |
| human papillomavirus test after conization in predicting residual disease in subsequent hysterectomy specimens. | to estimate the effectiveness of the human papillomavirus (hpv) test performed after conization in predicting residual disease in patients who subsequently underwent hysterectomy. | 2009 | 19546763 |
| human papillomavirus infection: a concise review of natural history. | persistent infection with oncogenic human papillomavirus (hpv), leading to precancerous lesions and potentially cervical cancer, is a serious health burden. the natural history of infection is one that enables the virus to remain immunoevasive within the cervical epithelium and persist for decades. many studies have provided important information on why some women clear infection and why others do not. the infectious process of hpv may be affected by many cofactors, adding to the complexity of d ... | 2009 | 19546771 |
| cervical cancers after human papillomavirus vaccination. | 2009 | 19546791 | |
| hpv16 tumor associated macrophages suppress antitumor t cell responses. | high-risk human papillomavirus (hpv) is the main etiologic factor for cervical cancer. the severity of hpv-associated cervical lesions has been correlated to the number of infiltrating macrophages. the objective of this work is to characterize the role of tumor-associated macrophages (tam) on the immune cellular response against the tumor. | 2009 | 19549768 |
| treatability by cryotherapy in a screen-and-treat strategy. | we estimated the percentage of women infected with human papillomavirus (hpv+) who cannot be immediately treated with cryotherapy. | 2009 | 19550216 |
| low rate of oral human papillomavirus (hpv) infection in women screened for cervical hpv infection in southern italy: a cross-sectional study of 140 immunocompetent subjects. | even though the natural history of cervical and oral human papillomavirus (hpv) infection has been investigated intensely, the possibility that hpv may infect both sites in the same subject is not well documented. this study investigated the frequency of concurrent oral and cervical hpv infection in southern italian women, in the light of some selected socio-behavioral variables. one hundred forty women (mean age: 36 years), with known cervical hpv status, were analyzed for oral hpv. age, smokin ... | 2009 | 19551817 |
| brd4 regulation of papillomavirus protein e2 stability. | the papillomavirus (pv) e2 protein is an important regulator of the viral life cycle. it has diverse roles in viral transcription, dna replication, and genome maintenance. our laboratory has previously identified the cellular bromodomain protein brd4 as a key interacting partner of e2. brd4 mediates the transcriptional activation function of e2 and plays an important role in viral genome maintenance in dividing cells. e2 interacts with the c-terminal domain (ctd) of brd4, and the ctd functions i ... | 2009 | 19553317 |
| detection and genotyping of human papillomavirus in self-obtained cervicovaginal samples by using the fta cartridge: new possibilities for cervical cancer screening. | this study assesses human papillomavirus (hpv) detection and genotyping in self-sampled genital smears applied to an indicating fta elute cartridge (fta cartridge). the study group consisted of 96 women, divided into two sample sets. all samples were analyzed by the hpv spf(10)-line blot 25. set 1 consisted of 45 women attending the gynecologist; all obtained a self-sampled cervicovaginal smear, which was applied to an fta cartridge. hpv results were compared to a cervical smear (liquid based) t ... | 2009 | 19553570 |
| establishing an anal dysplasia clinic for hiv-infected men: initial experience. | anal dysplasia caused by human papillomavirus (hpv) infection is common in the hiv-infected population and is a precursor to squamous cell carcinoma of the anus (scca). herein, we describe our initial experience in assessing the frequency and severity of anal intraepithelial neoplasia (ain) in a newly formed anal dysplasia clinic in seattle. during a 7-month period, 150 hiv-positive men were evaluated by digital rectal examination and high-resolution anoscopy (hra). forty-seven patients of the 1 ... | 2009 | 19554736 |
| role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review. | head and neck malignancies are characterized by a multiphasic and multifactorial etiopathogenesis. tobacco and alcohol consumption are the most common risk factors for head and neck malignancy. other factors, including dna viruses, especially human papilloma virus (hpv), may also play a role in the initiation or development of these lesions. the pathways of hpv transmission in the head and neck mucosal lesions include oral-genital contact, more than one sexual partner and perinatal transmission ... | 2009 | 19555477 |
| "u" shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in shanghai, china. | the purpose of the present study was to estimate the prevalence of high-risk human papillomavirus infection and the viral load in different age groups, to describe the distribution of human papillomavirus prevalence in women enrolled in two hospitals. | 2009 | 19525056 |
| elimination of high-risk human papillomavirus type hpv16 infection by 'praneem' polyherbal tablet in women with early cervical intraepithelial lesions. | 'praneem', a polyherbal formulation developed by us, has successfully completed phase ii efficacy study for treatment of abnormal vaginal discharge due to reproductive tract infections that act as co-factors for hpv persistence. in the present study we evaluated potential anti-hpv activity of praneem in women infected with high risk hpv type 16. | 2009 | 19526249 |
| prevalence of oncogenic human papillomavirus 16 and 18 in the palatine tonsils of the general adult population. | to determine whether there has been a demonstrable increase in the prevalence of human papillomavirus (hpv)-infected palatine tonsils corresponding to the increase in incidence of hpv-positive oropharyngeal squamous cell carcinoma (scc) over time. | 2009 | 19528402 |
| radiochemotherapy in locally advanced squamous cell carcinomas of the head and neck. | squamous cell carcinoma of the head and neck (scchn) is a common disease that develops in the upper aerodigestive epithelium. the most important risk factors are tobacco and alcohol consumption. there is also increasing evidence that human papillomavirus plays an important role in the cause of scchn. the complex anatomy, the vital functions of the upper aerodigestive tract and the close proximity to vital structures, explain that the goal of treatment is not only to improve survival outcomes, bu ... | 2009 | 19535232 |
| oncogenic activities of human papillomaviruses. | infectious etiologies for certain human cancers have long been suggested by epidemiological studies and studies with experimental animals. important support for this concept came from the discovery by harald zur hausen's group that human cervical carcinoma almost universally contains certain "high-risk" human papillomavirus (hpv) types. over the years, much has been learned about the carcinogenic activities of high-risk hpvs. these studies have revealed that two viral proteins, e6 and e7, that a ... | 2009 | 19540281 |
| human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. | anal condylomata acuminata (aca) are caused by human papilloma virus (hpv) infection which is transmitted by close physical and sexual contact. the result of surgical treatment of aca has an overall success rate of 71% to 93%, with a recurrence rate between 4% and 29%. the aim of this study was to assess a possible association between hpv type and aca recurrence after surgical treatment. | 2009 | 19543141 |
| dermatologic manifestations of hpv in hiv-infected individuals. | dermatologic human papillomavirus (hpv) infection in hiv patients manifests as both anogenital and nongenital skin disease. anogenital hpv-related disease includes benign condyloma acuminata, the most common cutaneous manifestation of genital hpv infection; intermediate malignancy or premalignant conditions including giant condyloma acuminata (also called buschke-loewenstein tumor), anal intraepithelial neoplasia, penile intraepithelial neoplasia, and vaginal or vulvar intraepithelial neoplasia; ... | 2009 | 19589298 |
| [treatment of respiratory papillomatosis--a case report on systemic treatment with bevacizumab]. | recurrent respiratory papillomatosis (rrp) is a known but rare disease, caused by human papilloma virus and characterised by multiple exophytic lesions and uncontrolled growth of papilloma in the respiratory tract. the most common complication of rrp is stenosis of the trachea. medical therapeutic options have so far been less effective. however, inhibition of vascular endothelial growth factor (vegf) by bevacizumab does appear to be an effective treatment option for rrp. | 2009 | 19591084 |
| cervical dysplasia and associated risk factors in a juvenile detainee population. | canada has licensed a human papilloma virus (hpv) vaccine for adolescent females, with the goal of decreasing the incidence of hpv infection and associated cervical cancer. this study identifies the juvenile detainee population as a high-risk group for hpv infection and therefore an important target for primary prevention. | 2009 | 19592281 |
| giant condyloma with demise secondary to meningococcemia in an infant boy. | human papilloma virus (hpv) is the most common sexually transmitted disease among adults in the usa; however, the presence of hpv in infants is rare. condyloma acuminata, a cutaneous, fungating lesion caused by hpv, has a generally mild course that often resolves spontaneously or can be managed both medically and surgically. typical treatments for condyloma include imiquimoid cream, podofilox gel, podophyllin resin, cryotherapy, laser surgery, tangential shave excision, and electrocautery. rapid ... | 2009 | 19596116 |
| identification of nucleolin as a protein that binds to human papillomavirus type 16 dna. | transcription, replication, and segregation of human papillomaviruses (hpvs) are regulated by various host factors, but our understanding of host proteins that bind to the hpv genome is limited. here we report the results of a search of cellular proteins that can associate with specific genomic regions of hpv type 16 (hpv16). we found that human nucleolin, an abundant nucleolar protein, was preferentially captured in vitro by an hpv16 genomic fragment from nucleotide positions (nt) 531-780. elec ... | 2009 | 19615975 |
| administration of hpv dna vaccine via electroporation elicits the strongest cd8+ t cell immune responses compared to intramuscular injection and intradermal gene gun delivery. | dna vaccines are an attractive approach to eliciting antigen-specific immunity. intracellular targeting of tumor antigens through its linkage to immunostimulatory molecules such as calreticulin (crt) can improve antigen processing and presentation through the mhc class i pathway and increase cytotoxic cd8+ t cell production. however, even with these enhancements, the efficacy of such immunotherapeutic strategies is dependent on the identification of an effective route and method of dna administr ... | 2009 | 19622402 |
| age-specific prevalence of hpv genotypes in cervical cytology samples with equivocal or low-grade lesions. | to define the spectrum of human papillomavirus (hpv) types and establish an age limit for triage hpv testing in atypical squamous cells of undetermined significance (ascus) and low-grade squamous intraepithelial lesion (lsil). | 2009 | 19623178 |
| importance of specimen type in detecting human papillomavirus dna from the female genital tract. | hpv testing is a valuable tool in cervical cancer screening and efficacy assessment of hpv vaccines. concordance of specimens from three sites for detection of hpv dna in the female genital tract was evaluated. at a single visit, the following specimens were collected: an endo-ecto-cervical swab (eec), labial/vulvar/perineal/perianal swab (lvpp) and cervicovaginal lavage (cvl). specimens were evaluated with hpv6, hpv11, hpv16, and hpv18 type- and gene-specific pcr assays. of the 898 women evalua ... | 2009 | 19626611 |
| genetic diversity of human papillomavirus type 16 e6, e7, and l1 genes in italian women with different grades of cervical lesions. | high-risk human papillomaviruses (hpvs) are risk factors for the development of cervical cancer. hpv 16 is the most common type, being present in about 60% of cervical cancers worldwide. previous studies have reported upon the association between hpv 16 e6 variants and increased risk of cervical intraepithelial neoplasia and invasive cervical cancer. in this study, the presence of hpv 16 polymorphisms in the e6, e7, and l1 genes was investigated in relation to the presence of high-grade lesions. ... | 2009 | 19626616 |
| [the expressions of ppar-gamma, cox-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis]. | to investigate the expression of ppar-gamma, cox-2 in the skin lesion of condyloma acuminatum and bowenoid papulosis. | 2009 | 19627000 |
| molecular epidemiology of sexually transmitted human papillomavirus in a self referred group of women in ireland. | human papillomavirus (hpv) causes cervical cancer and external genital warts. the purpose of this study is to document the genotype distribution of hpv in females aged between 18 and 34 who self-referred to an sti clinic with visible external genital warts (egw). scrapings were taken from visible external genital warts (egw). these scrapings were analysed by pcr for the presence of hpv dna. positive samples were then genotyped by means of a commercially available assay (lipa). a comparison of ge ... | 2009 | 19627586 |
| hpv 18 antibody levels, clinical efficacy and induced immune memory: a trio? | 2009 | 19628059 | |
| use of fta card for dry collection, transportation and storage of cervical cell specimen to detect high-risk hpv. | the fta elute micro card, which enable the collection, transport, and archiving of dna could be an attractive alternative to a liquid based collection system for detection of human papillomavirus (hpv). | 2009 | 19628427 |