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haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in a patient with chronic granulomatous disease and active infection: a first report.we describe haploidentical hematopoietic cell transplantation (hct) with high-dose post-transplant cyclophosphamide (ptcy) in a boy with x-linked chronic granulomatous disease (cgd).201526453586
[pulmonary non invasive infection by scedosporium apiospermum].we reported a case of non-invasive pulmonary infection by scedosporium apiospermum in 67 years old female with bronchiectasis and caverns secondary to tuberculosis. diagnosis was made with lung ct and bronchial lavage cultures. the patient was initially treated with itraconazole for six weeks without success and then voriconazole for 16 weeks, with good clinical response.201526436797
scedo-select iii: a new semi-selective culture medium for detection of the scedosporium apiospermum species complex.the scedosporium apiospermum complex is responsible for a large variety of infections in human. members of this complex have become emerging fungal pathogens with an increasing occurrence in patients with underlying conditions such as immunosuppression or cystic fibrosis. a better knowledge of these fungi and of the sources of contamination of the patients is required and more accurate detection methods from the environment are needed. in this context, a highly selective culture medium was devel ...201525841055
interaction between voriconazole and flucloxacillin during treatment of disseminated scedosporium apiospermum infection. 201525777322
a masquerading subcutaneous swelling caused by scedosporium apiospermum: an emerging pathogen.scedosporiasis is an emerging infection in immunocompromised individuals. we report a case of multiple subcutaneous swellings in a diabetic ketoacidotic patient, which was clinically diagnosed as lipoma. on fine-needle aspiration cytology, pus was aspirated, which showed septate branching hyphal elements. the pus culture on sabouraud's dextrose agar yielded scedosporium apiospermum, which was identified based on its macroscopic and microscopic features. there are very few reports of scedosporias ...201525673611
coccidioidomycosis and other systemic mycoses of marine mammals stranding along the central california, usa coast: 1998-2012.a wide range of systemic mycoses have been reported from captive and wild marine mammals from north america. examples include regionally endemic pathogens such as coccidioides and blastomyces spp., and novel pathogens like cryptococcus gattii, which appear may have been introduced to north america by humans. stranding and necropsy data were analyzed from three marine mammal stranding and response facilities on the central california coast to assess the prevalence, host demographics, and lesion d ...201525647598
case report of vertebral osteomyelitis and mycotic abdominal aortic aneurysm caused by scedosporium apiospermum in a lung transplant patient with cystic fibrosis.cystic fibrosis patients are frequently plagued by infections, often with unusual or hardy organisms. their infections are only complicated by transplantation. in this report, we review the case of a young woman who had a double lung transplant secondary to cystic fibrosis who developed a lumbar osteomyelitis/discitis several years after transplantation. after treatment, she went on to develop a mycotic abdominal aortic aneurysm. the patient underwent thoracic and abdominal aortic replacement, a ...201525645805
unusual case of scedosporium apiospermum keratitis following phacoemulsification in a systemically well patient.we report the case of a 65-year-old immunocompetent woman who developed scedosporium apiospermum keratitis after clear-corneal phacoemulsification. a 3.5 mm by 2.7 mm full-thickness stromal infiltrate, corresponding to the superior 2.75 mm clear-corneal incision, was observed 44 days postoperatively. treatment included preservative-free voriconazole 1.0% hourly, ofloxacin 0.3% 6 times a day, oral voriconazole 200 mg once daily, natamycin 5.0% hourly, dexamethasone 0.1% 4 times a day, and ocular ...201525532648
scedosporium apiospermum causing otomycosis in an immunocompetent child with tympanostomy tubes: management of this rare entity.infection following a tympanostomy tube insertion is a common occurrence. scedosporium apiospermum is a filamentous fungus mainly isolated in water and soil. there have been no reported cases of s. apiospermum infection of an immunocompetent individual with a tympanostomy tube in situ. a child was referred with unilateral otorrhoea failing to respond to conventional treatment in the community. s. apiospermum was identified following specialist testing. an extended course of anti-fungal treatment ...201526298623
scedosporium apiosermum infection of the "native" valve: fungal endocarditis in an orthotopic heart transplant recipient.scedosporium apiospermum is an increasingly appreciated pathogen in immunosuppressed patients. we present a case of s. apiospermum endocarditis in a 70-year-old male who had undergone orthotopic heart transplant. echocardiogram demonstrated a 1.4 cm tricuspid valve vegetation. he underwent valve replacement, complicated by fatal massive post-operative haemorrhage. valve cultures grew s. apiospermum. to our knowledge, our case is the first reported instance of endocarditis caused by s. apiospermu ...201526288748
scedosporium apiospermum infection after near-drowning. 201526228230
paradoxical response preceding control of scedosporium apiospermum mycetoma with posaconazole treatment.mycetoma is a chronic granulomatous infection that is difficult to treat, notably when due to fungi such as scedosporium apiospermum. recent antifungal agents could be an option, but cases are rarely reported, and none with posaconazole. paradoxical responses, defined as initial clinical worsening despite appropriate treatment, are common in tuberculosis but rare in deep mycoses in non-immunocompromised hosts. hence, paradoxical responses in context other than mycobacterial infection in an immun ...201526114987
scedosporium apiospermum otitis complicated by a temporomandibular arthritis: a case report and mini-review.scedosporium apiospermum is an ubiquitous fungus responsible for various infections in immunocompromised and immunocompetent patients. ear infections are infrequent. we report an exceptional case of s. apiospermum external otitis complicated by temporomandibular joint arthritis. after 6 months of antibiotherapy, diagnosis was established by mycological analysis of external auditory canal and infratemporal fossae needle sampling. a satisfactory outcome was obtained after 2 months of voriconazole ...201526105580
aortic arch mycotic aneurysm due to scedosporium apiospermum reconstructed with homografts.a 39-year-old female, active parenteral drug user was diagnosed of spondylodiscitis. a computed tomography (ct) scan showed an extensive aortic arch aneurysm. a positron emission tomography (pet)-ct scan, showing significant aortic wall uptake of the tracer through the whole aortic arch and the d8-d9 intervertebral disc, allowed us to suspect an aortitis despite negative blood cultures. the aneurysm was resected and reconstructed with 2 aortic homografts. cultures of specimens from the aortic wa ...201526046885
keratomycosis caused by graphium eumorphum (graphium state of scedosporium apiospermum).graphium eumorphum is rarely associated with mycotic keratitis. we report the case of a 30-year-old female presented with complaints of redness and defective vision in the left eye for one month. gram staining and 10% koh wet mount of corneal smears revealed fungal filaments. on potato dextrose agar, fast growing greyish white colonies turning grayish black on maturity was obtained. lactophenol cotton blue (lpcb) staining confirmed the isolate as graphium eumorphum. the infection was resolved wi ...201526023553
purification and characterization of a mycelial catalase from scedosporium boydii, a useful tool for specific antibody detection in patients with cystic fibrosis.scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a wide variety of infections in immunocompetent and immunocompromised individuals. this fungus belongs to the scedosporium apiospermum species complex, which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf) and may lead to allergic bronchopulmonary mycoses, sensitization, or respiratory infections. upon microbial infection, host phagocytic cells rel ...201525355796
human-impacted areas of france are environmental reservoirs of the pseudallescheria boydii/scedosporium apiospermum species complex.species of the pseudallescheria boydii/scedosporium apiospermum complex (psc) are emerging fungal pathogens able to chronically colonize the airways of patients with cystic fibrosis (cf). as p. boydii was found more frequently colonizing the lungs of cf patients in france than in other european countries in a previous report, the present study was conducted in order to clarify distribution of psc species in france and to characterize their natural habitat. the highest densities of psc isolates w ...201524684308
[deep skin infection with scedosporium apiospermum-infection in a renal transplant patient].a 57-year-old immunosuppressed patient presented with multiple erythematous papules and pustules as well as isolated ulcerations on the right lower leg and subcutaneous nodules on the right thigh. the biopsy revealed granulomatous inflammation with numerous fungal hyphae, which were identified as scedosporium apiospermum by pcr. he was treated with voriconazole 2 × 200 mg daily as well assurgical debridement. scedosporium apiospermum is a rare pathogenic agent of deep mold fungus infections. ski ...201525260303
scedosporium apiospermum: an unreported cause of fungal sporotrichoid-like lymphocutaneous infection in australia and review of the literature.scedosporium apiospermum is a fungus emerging as a rare but important cause of both localised and disseminated infections in immunocompromised patients. most cutaneous lesions present as mycetoma, however a review of the literature revealed an increasing number of cases worldwide presenting with lymphocutaneous spread resembling sporotrichosis. an 85-year-old man with an extensive medical history including type ii diabetes mellitus and meningioma presented with crusted haemorrhagic areas on the ...201524266687
fungal septal abscess complicating maxillary sinus fungus balls in an immunocompetent host.fungal infections of the nasal cavity can be destructive entities that are typically seen in immunocompromised hosts. we present a case of a localized fungal abscess of the nasal septum in an immunocompetent host after endoscopic treatment of maxillary sinus fungus balls.201526686210
cutaneous pseudallescheria boydii/scedosporium apiospermum complex (molecular type: scedosporium apiospermum [clade 4]) infection: a case report and literature review of cases from japan.we report a case of subcutaneous pseudallescheria boydii/scedosporium apiospermum complex infection occurring in a 77-year-old japanese female farmer suffering from interstitial pneumonia. seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. yellowish-white, rice-grain-sized pustules ...201526617105
identifying the emerging human pathogen scedosporium prolificans by using a species-specific monoclonal antibody that binds to the melanin biosynthetic enzyme tetrahydroxynaphthalene reductase.the dematiaceous (melanized) fungus scedosporium prolificans is an emerging and frequently fatal pathogen of immunocompromised humans and which, along with the closely related fungi pseudallescheria boydii, scedosporium apiospermum and s. aurantiacum in the pseudallescheria-scedosporium complex, is a contributing aetiology to tsunami lung and central nervous system infections in near-drowning victims who have aspirated water laden with spores. at present, the natural habitat of the fungus is lar ...201524684242
osteoarticular infections caused by non-aspergillus filamentous fungi in adult and pediatric patients: a systematic review.osteoarticular mycoses due to non-aspergillus moulds are uncommon and challenging infections. a systematic literature review of non-aspergillus osteoarticular mycoses was performed using pubmed and embase databases from 1970 to 2013. among 145 patients were 111 adults (median age 48.5 [16-92 y]) and 34 pediatric patients (median age 7.5 [3-15 y]); 114 (79.7%) were male and 88 (61.9%) were immunocompromised. osteomyelitis was due to direct inoculation in 54.5%. trauma and puncture wounds were mor ...201526683917
n-chlorotaurine exhibits fungicidal activity against therapy-refractory scedosporium species and lomentospora prolificans.n-chlorotaurine (nct), a well-tolerated endogenous long-lived oxidant that can be applied topically as an antiseptic, was tested on its fungicidal activity against scedosporium and lomentospora, opportunistic fungi that cause severe infections with limited treatment options, mainly in immunocompromised patients. in quantitative killing assays, both hyphae and conidia of scedosporium apiospermum, scedosporium boydii, and lomentospora prolificans (formerly scedosporium prolificans) were killed by ...201526239996
prevalence of scedosporium species and lomentospora prolificans in patients with cystic fibrosis in a multicenter trial by use of a selective medium.detection of hyphomycetes of the scedosporium apiospermum complex and lomentospora prolificans (sac-lp) is not yet standardized. prevalence rates in patients with cystic fibrosis (cf) and the resistance pattern of these pathogens in germany are unknown.201525595044
effect of water activity and titania p25 photocatalyst on inactivation of pathogenic fungi--contribution to the protection of public health.the aim of this study was to determine the antifungal activity of titanium dioxide activated by indoor light on czapek yeast agar (cya).201526615661
the effect of anatase and rutile crystallites isolated from titania p25 photocatalyst on growth of selected mould fungi.antifungal properties of anatase and rutile crystallites isolated from commercial titania p25 photocatalyst were investigated by mycelium growth in the dark and under indoor light. investigated fungi, i.e., pseudallescheria boydii, scedosporium apiospermum, pseudallescheria ellipsoidea, scedosporium aurantiacum, aspergillus versicolor, aspergillus flavus, stachybotrys chartarum, penicillium chrysogenum, aspergillus melleus, were isolated from air and from moisture condensed on walls. anatase and ...201526177513
discrimination of aspergillosis, mucormycosis, fusariosis, and scedosporiosis in formalin-fixed paraffin-embedded tissue specimens by use of multiple real-time quantitative pcr assays.in a retrospective multicenter study, 102 formalin-fixed paraffin-embedded (ffpe) tissue specimens with histopathology results were tested. two 4- to 5-μm ffpe tissue sections from each specimen were digested with proteinase k, followed by automated nucleic acid extraction. multiple real-time quantitative pcr (qpcr) assays targeting the internal transcribed spacer 2 (its2) region of ribosomal dna, using fluorescently labeled primers, was performed to identify clinically important genera and spec ...201627605714
evaluation of antifungal efficacy of 0.1% and 0.25% riboflavin with uva: a comparative in vitro study.antifungal efficacy of photochemical cross-linking (pack-cxl) with 0.1% and 0.25% riboflavin was evaluated with a comparative in vitro study.201626644282
structural analysis of glucosylceramides (glccer) from species of the pseudallescheria/scedosporium complex.glucosylceramides (glccer) are the main neutral glycosphingolipids expressed in fungal cells. in this work, glucosylceramides (glccer) were extracted from three strains of scedosporium (pseudallescheria) boydii, one strain of pseudallescheria ellipsoidea and one strain of pseudallescheria angusta and purified by several chromatographic steps. using high-performance thin layer chromatography (hptlc), we found a similarity between glccer obtained from all of the analysed strains. a detailed struct ...201626781373
prevention of polymicrobial biofilms composed of pseudomonas aeruginosa and pathogenic fungi by essential oils from selected citrus species.mixed microbial infections caused by pseudomonas aeruginosa and pathogenic fungi are commonly found in patients with chronic infections and constitute a significant health care burden. the aim of this study was to address the potential polymicrobial antibiofilm activity of pompia and grapefruit essential oils (eos). the mechanism of antimicrobial activity of eos was analysed. eos of pompia and grapefruit inhibited fungal growth with mic concentrations between 50 and 250 mg l(-1), whereas no effe ...201627702795
cyclophilin and enolase are the most prevalent conidial antigens of lomentospora prolificans recognized by healthy human salivary iga and cross-react with aspergillus fumigatus.the study of the immunocompetent airways immune response may provide important information to improve the therapeutic efficacy against lomentospora (scedosporium) prolificans. so, this study aimed to identify the most prevalent conidial antigens of this multiresistant fungus recognized by healthy human salivary immunoglobulin a, and to study their expression and cross-reactivity with other fungal species.201627485921
fungal infection of cystic fibrosis patients - single center experience.cystic fibrosis (cf) is the most common monogenetic autosomal recessive disease in the human population. this systemic disease is characterized by changes in multiple organs, mainly in the lung tissue and digestive tract. more than 59% of cf patients become sensitized to fungal spores, mostly aspergillus fumigatus. 5-15% of cf patients develop allergic bronchopulmonary aspergillosis. the aim of the study was to analyse the occurrence of yeast and filamentous fungi of the respiratory infections i ...201627238177
antifungal susceptibilities of non-aspergillus filamentous fungi causing invasive infection in australia: support for current antifungal guideline recommendations.antifungal susceptibilities of non-aspergillus filamentous fungal pathogens cannot always be inferred from their identification. here we determined, using the sensititre(®) yeastone(®) yo10 panel, the in vitro activities of nine antifungal agents against 52 clinical isolates of emergent non-aspergillus moulds representing 17 fungal groups in australia. isolates comprised mucorales (n = 14), scedosporium/lomentospora spp. (n = 18) and a range of hyaline hyphomycetes (n = 9) and other dematiaceous ...201627562696
new record of scedosporium dehoogii from chile: phylogeny and susceptibility profiles to classic and novel putative antifungal agents.scedosporium species are considered emerging agents causing illness in immunocompromised patients. in chile, only scedosporium apiospermum, scedosporium boydii and lomentospora prolificans haven been reported previously.201627461998
conidial germination in scedosporium apiospermum, s. aurantiacum, s. minutisporum and lomentospora prolificans: influence of growth conditions and antifungal susceptibility profiles.in the present study, we have investigated some growth conditions capable of inducing the conidial germination in scedosporium apiospermum, s. aurantiacum, s. minutisporum and lomentospora prolificans. germination in sabouraud medium (ph 7.0, 37ºc, 5% co2) showed to be a typically time-dependent event, reaching ~75% in s. minutisporum and > 90% in s. apiospermum, s. aurantiacum and l. prolificans after 4 h. similar germination rate was observed when conidia were incubated under different media a ...201627355215
assessment of biofilm formation by scedosporium apiospermum, s. aurantiacum, s. minutisporum and lomentospora prolificans.reported herein is the ability of scedosporium apiospermum, s. aurantiacum, s. minutisporum and lomentospora prolificans conidia to adhere, differentiate into hyphae and form biofilms on both polystyrene and lung epithelial cells. to different degrees, all of the fungi adhered to polystyrene after 4 h, with a predominance of those with germinated conidia. prolonged fungi-polystyrene contact resulted in the formation of a monolayer of intertwined mycelia, which was identified as a typical biofilm ...201627309801
towards proteomic species barcoding of fungi - an example using scedosporium/pseudallescheria complex isolates.maldi-tof mass spectrometry offers fast and reliable species identification for bacteria and yeasts under clinical routine conditions. here, we produced mass spectra for identification of clinically important species of the pseudallescheria/scedosporium complex using the recently suggested new nomenclature and use this example to discuss to what extent the principle of dna barcoding might be transferred to mass spectrometry.201626781372
beware of rim-enhancing lesions: a rare case of multiple scedosporium apiospermum and vancomycin-resistant enterococcus faecium intra-cranial abscesses.the aim of this submission is to demonstrate the need for broad antimicrobial therapy, including empiric anti-fungal therapy, if rim-enhancing lesions are noted on cerebral imaging.201627045172
intra- and interspecific diversity of ultrastructural markers in scedosporium.ultrastructural features of conidia, lateral walls of aerial and submerged hyphal cells, and of septal pore apparatus of scedosporium apiospermum, s. boydii, pseudallescheria angusta and scedosporium aurantiacum were studied. submerged hyphal cells possessed a thick extracellular matrix. crystalline satellites accessory to the septal pore apparatus were revealed. fundamental ultrastructural features appeared to be heterogeneous at low taxonomic levels. the closely interrelated members of the s. ...201626781370
the 'species complex' issue in clinically relevant fungi: a case study in scedosporium apiospermum.the genus scedosporium currently comprises six species, scedosporium apiospermum, scedosporium boydii, pseudallescheria angusta, scedosporium minutisporum, scedosporium dehoogii, and scedosporium aurantiacum, most of which can be distinguished with the primary fungal dna barcode, the its1/2 region of the rdna gene cluster. in the present study, four additional genetic loci were explored from a phylogenetic point of view enabling a barcoding approach based on k2p pairwise distances to resolve the ...201626781369
endophthalmitis of probable endogenous origin caused by scedosporium boydii: a case report.mycotic ocular infections caused by the scedosporium apiospermum species complex are challenging to treat because of the delayed diagnoses and poor responses to antifungal drugs and surgical treatment.201626874584
semi-automated repetitive sequence-based pcr amplification for species of the scedosporium apiospermum complex.the scedosporium apiospermum species complex usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf), but little is known about the molecular epidemiology of the airway colonization.201626486722
scedosporiosis in a combined kidney and liver transplant recipient: a case report of possible transmission from a near-drowning donor.scedosporium spp. are saprobic fungi that cause serious infections in immunocompromised hosts and in near-drowning victims. solid organ transplant recipients are at increased risk of scedosporiosis as they require aggressive immunosuppression to prevent allograft rejection. we present a case of disseminated scedosporium apiospermum infection occurring in the recipient of a combined kidney and liver transplantation whose organs were donated by a near-drowning victim and review the literature of s ...201628070441
rapid development of a mycotic aneurysm of the intracranial artery secondary to scedosporium apiospermum sinusitis.an 85-year-old man complained of a 2-month history of pain on the left side of his face. brain computed tomography (ct) and magnetic resonance imaging/magnetic resonance angiography did not clearly show any intracranial abnormality and only showed fluid effusion in his left sphenoid sinus. filamentous fungi were detected from the left sphenoid sinus specimen. the isolate was scedosporium apiospermum. he was empirically treated with voriconazole, to which the isolate was susceptible. his consciou ...201628053848
eyelid mycetoma masquerading as sebaceous carcinoma.a 56-year-old asian woman presented with an upper eyelid mass. the lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. working diagnosis was sebaceous carcinoma. biopsy was performed. histopathological studies showed a mycotic eumycetoma with splendore-hoeppli phenomena and - microbiologic cultures grew scedosporium apiospermum. the patient was started on voriconazole 200 mg po bid with adequate serum levels. a complete response was observed after 1 ...201626882058
concurrent pyoderma gangrenosum and infection with scedosporium apiospermum.we present a patient with pyoderma gangrenosum (pg) following hip surgery, who developed an exacerbation of her ulceration in conjunction with new areas on her lower limbs. clinically, features of pg and deep fungal infection were apparent. scedosporium apiospermum was isolated from the ulcers.201625920922
disseminated scedosporium apiospermum infection in a near-drowning patient. 201625865289
cutaneous pseudallescheria boydii/scedosporium apiospermum complex infection in immunocompromised patients: a report of two cases. 201627666328
safety and clinical response of intraventricular caspofungin for scedosporium apiospermum complex central nervous system infection.we present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolerated. within weeks of discontinuation, the patient experienced clinical deterioration with disease progression. there are sparse data on the efficacy and safety of administering intraventricular caspof ...201627656356
scedosporium apiospermum: a rare cause of malignant otitis externa.a 79-year-old man, with a history of well-controlled diabetes mellitus, presented with left-sided otalgia. with an initial diagnosis of simple otitis externa, he was discharged on topical drops. he represented 2 months later with worsening otalgia and discharge. a diagnosis of malignant otitis externa was made based on clinical and radiological findings. intravenous tazocin and gentamicin were given based on previous bacterial culture from ear swabs. the patient failed to improve and developed l ...201627613266
environmental screening for the scedosporium apiospermum species complex in public parks in bangkok, thailand.the scedosporium apiospermum species complex, comprising filamentous fungal species s. apiospermum sensu stricto, s. boydii, s. aurantiacum, s. dehoogii and s. minutispora, are important pathogens that cause a wide variety of infections. although some species (s. boydii and s. apiospermum) have been isolated from patients in thailand, no environmental surveys of these fungi have been performed in thailand or surrounding countries. in this study, we isolated and identified species of these fungi ...201627467209
favorable outcomes of filamentous fungal endophthalmitis following aggressive management.to evaluate the visual outcomes following aggressive management of filamentous fungal endophthalmitis with prompt surgical intervention and oral and intravitreal voriconazole.201627447804
scedosporium apiospermum and s. prolificans mixed disseminated infection in a lung transplant recipient: an unusual case of long-term survival with combined systemic and local antifungal therapy in intensive care unit.infections due scedosporium spp. in lung transplant recipients are associated with disseminated disease with high mortality rates. the adjunctive local antifungal therapy may be a useful option when systemic treatment is insufficient and/or surgery is not feasible. we present a case of mixed disseminated infection due scedosporium apiospermum and s. prolificans in a lung transplant recipient. combined local and systemic antifungal therapy provided an unusual long-term survival in the intensive c ...201627222774
scedosporium apiospermum infections and the role of combination antifungal therapy and gm-csf: a case report and review of the literature.scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. it poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. we present an immunocompromised patient with a cutaneous s. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. adding echinocandins and gm-csf provided part ...201627182483
scedosporium apiospermum as a rare cause of central skull base osteomyelitis.we report a case of scedosporium apiospermum mold causing ear infection, central skull base osteomyelitis and finally, occlusion of carotid artery in a 48-year-old diabetic man. the exact diagnosis was established and the severity of the disease understood several months after the onset of symptoms. despite of appropriate antifungal therapy, and repeated surgical and otological procedures, the infection progressed to fatal cerebral infarction.201627134821
histopathological clues in the diagnosis of fungal infection by scedosporium in a case of endophthalmitis starting as conjunctivitis.cutaneous fungal infections can result in disastrous episodes if improperly diagnosed and treated, especially in immunosuppressed patients. although dermatopathologists are highly familiar with some filamentous fungi - such as aspergillus and zygomycetes - they are not so aware of other less common species. we report a case of ocular infection by scedosporium apiospermum that started as conjunctivitis and resulted in phthisis bulbi and subsequent exeresis of the left eye. we describe some of the ...201626968327
acute scedosporium apiospermum endobronchial infection in cystic fibrosis.fungi are known pathogens in cystic fibrosis patients. a boy with cystic fibrosis boy presented with acute respiratory distress. bronchoscopy showed airways obstruction by mucus plugs and bronchial casts. scedosporium apiospermum was identified as the only pathogen. bronchoalveolar lavage successfully resolved the acute obstruction. plastic bronchitis is a new clinical picture of acute scedosporium endobronchial colonization in cystic fibrosis patients.201626967814
invasive lung infection by scedosporium apiospermum in an immunocompetent individual.scedosporium apiospermum previously known as monospermum apiospermum is a ubiquitous fungus found in soil, polluted water and sewage. it causes broad spectrum of diseases, including soft tissue infections, septic arthritis, osteomyelitis, ophthalmic infections, sinusitis, pneumonia, meningitis, brain abscesses, endocarditis and disseminated infection. in recent years, it has been shown to be pathogenic for both immunocompetent and immunosuppressed patients. it is a significant opportunist with v ...201625308027
pulmonary scedosporiosis mimicking aspergilloma in an immunocompetent host: a case report and review of the literature.a case of localized lung scedosporiosis is reported here that mimicked aspergilloma in an immunocompetent host. through this case the importance of considering scedosporium spp. in differential diagnosis of locally invasive lung infections and fungal ball is highlighted. as it is difficult to differentiate scedosporium from aspergillus on clinical grounds, microscopy, radiology and histopathology, this case is further emphasizing the significance of the definitive etiological characterization of ...201626353885
post-traumatic endophthalmitis secondary to keratomycosis caused by scedosporium apiospermum. 201624724836
tenosynovitis caused by scedosporium apiospermum infection misdiagnosed as an alternaria species: a case report.scedosporium apiospermum, which can usually be isolated from soil, polluted stream water and decaying vegetation, is increasingly recognized as an opportunistic dematiaceous fungus. the mortality rate of infection in immunocompromised hosts is over 50%. s. apiospermum is commonly responsible for dermal and epidermal infections (i.e., mycetoma) after traumatic penetration.201728088169
scedosporium apiospermum mycetoma in an immunocompetent patient without prior lung disease. 201728035880
voriconazole mics are predictive for the outcome of experimental disseminated scedosporiosis.scedosporiosis is associated with a mortality rate of up to 90% in patients suffering from disseminated infections. recommended first-line treatment is voriconazole, but epidemiological cut-off values and clinical breakpoints have not been determined.201728031271
clinico-radiological improvement in an immunocompetent patient presented with scedosporium apiospermum osteomyelitis.scedosporium apiospermum is frequently found as a saprophyte in soil, sewage and contaminated water. its manifestations in immunocompetent patients are usually localised and in immunodeficient patients, it causes invasive systemic diseases. we are reporting the case of a 40-year-old male, who presented with pain, oedema and multiple discharging sinuses over the lateral aspect of the left foot with history of thorn prick. on examination, there were multiple active sinuses with tenderness and loca ...201728018093
fatal bilateral haemopneumothoraces following double-lung transplantation caused by pretransplant colonization by scedosporium apiospermum. 201728329186
prompt diagnosis of scedosporium apiospermum soft tissue infection: life-saving in a renal transplant recipient.scedosporium apiospermum, an ubiquitous filamentous fungus, a known cause of mycetoma, is emerging as an opportunistic pathogen in immunocompromised individuals. we report a case of painful foot abscess in a renal allograft recipient on immunosuppressive therapy, which was clinically diagnosed as a suppurative bacterial abscess. pus was aspirated, which showed septate, branching hyphal elements and culture on sabouraud's dextrose agar yielded s. apiospermum, which was identified based on its mac ...201728272067
surgical resection of a rare cutaneous manifestation of scedosporium apiospermum in a patient who underwent renal transplant.a man aged 47 years who was immunosuppressed following renal transplantation for focal segmental glomerulosclerosis was referred to the plastic surgery team for management of a painful, chronic, granulomatous lesion of the right forearm. serial ultrasound scans and mri scans were not diagnostic, but microbiological specimens tested positive for the fungus scedosporium apiospermum the renal transplant graft-which was failing-was removed, allowing him to cease immunosuppression. he then underwent ...201728115402
dihydroorotate dehydrogenase inhibitor f901318 has potent in vitro activity against scedosporium species and lomentospora prolificans.scedosporium species and lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. our objective was to assess the in vitro potency of f901318, a member of the orotomide class of antifungals, against scedosporium species and l. prolificans .201728333310
anthropogenic impact on environmental filamentous fungi communities along the mediterranean littoral.we hypothesised that anthropogenic influences impact the filamentous fungi community structure and that particular species or species patterns might serve as markers to characterise ecosystems. this study aimed to describe the filamentous fungi community structure in various biotopes along the mediterranean shore that were exposed to various levels of anthropogenic influence. we sampled filamentous fungi from yellow-legged gull faecal samples at five study sites along the mediterranean littoral ...201728276198
review of 21 cases of mycetoma from 1991 to 2014 in rio de janeiro, brazil.mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. the purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the oswaldo cruz foundation in rio de janeiro, brazil, between 1991 and 2014. twenty-one cases of mycetoma were included in the study. there was a predominance of male patients (1.3:1) and the average patient age was 46 yea ...201728192433
bactericidal and fungicidal activity of n-chlorotaurine is enhanced in cystic fibrosis sputum medium.lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (cf). n-chlorotaurine (nct), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. the aim of this study was to investigate nct on its bactericidal and fungicidal activity in vitro in artificial sputum medium (asm) mimicking the composition of cystic fibrosis mucus.the medium was inoculated with bacteria (staphylococcus aureus including ...201728223376
prospective multicenter german study on pulmonary colonization with scedosporium /lomentospora species in cystic fibrosis: epidemiology and new association factors.an increasing rate of respiratory colonization and infection in cystic fibrosis (cf) is caused by fungi of the scedosporium apiospermum species complex or lomentospora prolificans (sac-lp). these fungi rank second among the filamentous fungi colonizing the cf airways, after aspergillus fumigatus. however, the epidemiology, clinical relevance and risk of pulmonary colonization with sac-lp are rarely understood in cf. the objective of the present prospective multicenter study was to study pathogen ...201728178337
does the benefit of salvage amputation always outweigh disability in drug-failure mycetoma?: a tale of two cases.it is popularly believed that eumycetoma cases should be dealt with using surgical amputation for a better chance of cure especially when chemotherapy has failed. however, amputation leads to disability on one hand and on the other it may also fail to be curative. we present two cases with contrasting treatment options and outcome. in the eumycetoma case reported here, a 40-year-old male presented with right foot swelling for 16 years, from which scedosporium apiospermum was isolated. he respond ...201725657401
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