Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| anticancer potential of curcumin: preclinical and clinical studies. | curcumin (diferuloylmethane) is a polyphenol derived from the plant curcuma longa, commonly called turmeric. extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. the anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulate transcription factors nf-kappa b, ap-1 and egr-1; down-regulate the expression of cox2, lox, nos, mmp-9, upa, tnf, chemokines, cell surface adhesion m ... | 2003 | 12680238 |
| lens aldose reductase inhibiting potential of some indigenous plants. | cataract is the leading cause of blindness worldover. diabetes is one of the major risk factors for cataractogenesis and aldose reductase (ar) has been reported to play an important role in sugar-induced cataract. in the present study, the ar inhibitory activity of ocimum sanctum (os), withania somnifera (ws), curcuma longa (cl), azadirachta indica (ai) were studied together with their effect on sugar-induced cataractogenic changes in rat lenses in vitro. aqueous extracts of the plants, procured ... | 2003 | 12686449 |
| inhibition of protease-resistant prion protein accumulation in vitro by curcumin. | inhibition of the accumulation of protease-resistant prion protein (prp-res) is a prime strategy in the development of potential transmissible spongiform encephalopathy (tse) therapeutics. here we show that curcumin (diferoylmethane), a major component of the spice turmeric, potently inhibits prp-res accumulation in scrapie agent-infected neuroblastoma cells (50% inhibitory concentration, approximately 10 nm) and partially inhibits the cell-free conversion of prp to prp-res. in vivo studies show ... | 2003 | 12692251 |
| functional properties of spice extracts obtained via supercritical fluid extraction. | in the present study the antioxidant, anticancer, and antimycobacterial activities of extracts from ginger (zingiber officinale roscoe), rosemary (rosmarinus officinalis l.), and turmeric (curcuma longa l.) were evaluated. the extracts were obtained using supercritical co(2) with and without ethanol and/or isopropyl alcohol as cosolvent. the extracts' antioxidant power was assessed using the reaction between beta-carotene and linolenic acid, the antimycobacterial activity against m. tuberculosis ... | 2003 | 12696930 |
| randomised, double-blind, placebo-controlled parallel group study of p54fp for the treatment of dogs with osteoarthritis. | p54fp is an extract of indian and javanese turmeric, curcuma domestica and curcuma xanthorrhiza respectively, which contains a mixture of active ingredients including curcuminoids and essential oils. a randomised, double-blind, placebo-controlled, parallel group clinical trial of p54fp as a treatment for osteoarthritis of the canine elbow or hip was conducted to assess its efficacy and safety. sixty-one client-owned dogs with osteoarthritis were recruited through first-opinion practices and exam ... | 2003 | 12723628 |
| curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. | 1 inflammmatory bowel disease (ibd) is characterized by oxidative and nitrosative stress, leucocyte infiltration and upregulation of proinflammatory cytokines. in this study, we have investigated the protective effects of curcumin, an anti-inflammatory and antioxidant food derivative, on 2,4,6- trinitrobenzene sulphonic acid-induced colitis in mice, a model for ibd. 2 intestinal lesions (judged by macroscopic and histological score) were associated with neutrophil infiltration (measured as incre ... | 2003 | 12770926 |
| suppression of altered hepatic foci development by curcumin in wistar rats. | curcumin, a yellow pigment of turmeric (curcuma longa), is a commonly used spice and a coloring agent in foods, drugs, and cosmetics. curcumin is known to possess chemopreventive properties in various animal tumor models. in the present study the effect of curcumin on the development of altered hepatic foci (ahf), by using a medium term liver bioassay, has been evaluated. ahf were analyzed by quantitative stereology using the leica qwin image analysis system from frozen liver sections stained fo ... | 2003 | 12791505 |
| effect of curcumin on galactose-induced cataractogenesis in rats. | curcumin, the active principle of turmeric, has been shown to have both antioxidant and hypoglycemic activity in vitro and in vivo. the purpose of this study was to investigate the effect of curcumin on the onset and maturation of galactose induced cataract. | 2003 | 12802258 |
| efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin. | curcumin is a predominant compound derived from the rhizomes of curcuma longa l., and shows antibacterial, anti-inflammatory and antineoplastic activity. the in-vitro and in-vivo skin absorption of curcumin was investigated after application of enhancers using wistar rat as an animal model. the enhancers selected in this study included terpenes, flavonoids and cholestanol. the irritant profiles of these enhancers were also established by transepidermal water loss (tewl) and histological observat ... | 2003 | 12831501 |
| antioxidant activity of smoke shield in-vitro and in-vivo. | smoke shield is a proprietory formulation containing extract of turmeric (curcuma longa), obtained by supercritical carbon dioxide gas extraction and post-supercritical hydroethanolic extraction, together with extracts of green tea and other spices whose presence synergistically increases the activity of turmeric. this study evaluates the antioxidant potentials of smoke shield in-vitro and in experimental animals, as well as in human models. smoke shield was found to scavenge superoxide radicals ... | 2003 | 12841947 |
| curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. | anti-asthmatic property of curcumin (diferuloylmethane), a natural product from the rhizomes of curcuma longa, has been tested in a guinea pig model of airway hyperresponsiveness. we sensitized guinea pigs with ovalbumin (ova) to develop certain characteristic features of asthma: allergen induced airway constriction and airway hyperreactivity to histamine. guinea pigs were treated with curcumin during sensitization (to examine its preventive effect) or after developing impaired airways features ... | 2003 | 12843631 |
| curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and nf-kappab activation. | recently, there have been considerable efforts to search for naturally occurring substances for the intervention of carcinogenesis. many components derived from dietary or medicinal plants have been found to possess substantial chemopreventive properties. curcumin, a yellow coloring ingredient of turmeric (curcuma longa l., zingiberaceae), has been shown to inhibit experimental carcinogenesis and mutagenesis, but molecular mechanisms underlying its chemopreventive activities remain unclear. in t ... | 2003 | 12844482 |
| screening of antimutagenicity via antioxidant activity in cuban medicinal plants. | the reducing activity on the 1,1-diphenyl-2-picrylhydrazyl (dpph) radical, z.rad;oh radical scavenging potential, in vitro inhibition of lipid peroxidation and modulation of mutagenicity induced by ter-butyl hydroperoxide (tbh) in escherichia coli were sequentially screened in 45 species of plants used with medicinal purposes in cuba, in a search for antioxidant agents which protect dna against oxidative stress.five species, e.g. tamarindus indica l., lippia alba l., pimenta dioica (l.) merr, rh ... | 2003 | 12860316 |
| authentication of panax notoginseng by 5s-rrna spacer domain and random amplified polymorphic dna (rapd) analysis. | the great majority of panax species are well-known herbal medicines in the orient, and many of them share a close resemblance in appearance and chemical composition. among these panax species, the root of p. notoginseng (sanqi) is a unique herb that has distinct clinical usage. here, the 5s-rrna spacer domains were isolated from p. notoginseng, p. japonicus var. major, p. stipuleanatus, p. quinquefolius, p. ginseng, p. zingiberensis, and p. wangianus, and four common adulterants of p. notoginsen ... | 2003 | 12865989 |
| antitumor activity of extract of zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. | the anticancer properties of zerumbone (2,6,9 humulatriene-8-one, a sesquiterpenoid) from zingiber aromaticum were compared with those of curcumin from curcuma longa in an in vitro mtt tetrazolium salt assay using ht-29, caco-2, and mcf-7 cancer cells and in an azoxymethane (aom)-induced animal model of colon cancer using aberrant crypt foci (acfs) as a preneoplastic marker. the ic50 of zerumbone was approximately 10 mm and that of curcumin was 25 mm. cell cycle arrest in ht-29 cells was observe ... | 2003 | 12881017 |
| effects of curcuma drugs on vasomotion in isolated rat aorta. | the effectiveness of curcuma drugs against "oketsu" and the differences in their efficacy were evaluated by examining their vasomotional effects as one index. since nitric oxide (no) is the relaxation factor of vascular smooth muscle and also an inhibitor of platelet aggregation in blood vessels, substances showing no-dependent relaxation are thought to be effective in improving oketsu. in this study, five curcuma drugs derived from curcuma longa, c. kwangsiensis, c. phaeocaulis, c. wenyujin, an ... | 2003 | 12913265 |
| oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet. | the aim of this study was to evaluate the effects of an oral supplementation with a curcuma longa ethanol and aqueous extract on the susceptibility to oxidation of cellular and subcellular membranes affected in the atherosclerotic process, such as erythrocyte membranes and liver microsomes, in rabbits fed with a high-fat diet. | 2003 | 12921893 |
| antispasmodic effects of curcuminoids on isolated guinea-pig ileum and rat uterus. | curcuminoids, a yellow constituent isolated from curcuma longa linn. rhizomes was studied for its antispasmodic activity in isolated guinea-pig ileum and rat uterus. curcuminoids at the concentration of 12 microg/ml significantly inhibited the ileum pre-contracted with acetylcholine (ach) 5 x 10(-7) m and histamine 5 x 10(-7) m. (force of contraction was 62.84 +/- 4.66% and 75.60 +/- 4.66% respectively) and the effects were prominently observed when the concentration of curcuminoids was increase ... | 2003 | 12930003 |
| inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens. | dibenzoylmethane (dbm), a structural analogue of curcumin (a bioactive phytochemical present in a widely used spice turmeric) was screened for its inhibitory effect against seven cooked food mutagens (heterocyclic amines): 2-amino-3-methylimidazo[4,5-f]quinoline (iq), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (meiq), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (meiqx), 3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole (trp-p-1), 3-amino-1-methyl-5h-pyrido[4,3-b]indole (trp-p-2), 2-amino-1-methyl-6 ... | 2003 | 13678246 |
| curcumin inhibits uv irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma a431 cells. | ultraviolet (uv) light is a strong apoptotic trigger that induces caspase-dependent biochemical changes in cells. previously we showed that uv irradiation can activate caspase-3, and the subsequent cleavage and activation of p21(cdc42/rac)-activated kinase 2 (pak2) in human epidermoid carcinoma a431 cells. in this study we demonstrate that curcumin (cur), the yellow pigment of curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent uv irradiation-induced apoptotic cha ... | 2003 | 14505349 |
| induction of apoptosis by curcumin: mediation by glutathione s-transferase p1-1 inhibition. | expression of glutathione s-transferase p1-1 (gstp1-1) is correlated to carcinogenesis and resistance of cancer cells against chemotherapeutic agents. curcumin, a natural compound extracted from curcuma longa, has shown strong antioxidant and anticancer properties and also the ability to regulate a wide variety of genes that require activating protein 1 and nuclear factor kappab (nf-kappab) activation. in the present study, we examined the inhibitory effect of curcumin on the expression of gstp1 ... | 2003 | 14555224 |
| sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma. | an hplc assay was developed using three methods of plasma sample preparation in order to quantitate curcumin, the main constituent in the herbal dietary supplement turmeric. each method involves simple and rapid processing of samples (either an ethyl acetate or chloroform extraction) with resulting different quantitation limits for curcumin. the assay was developed in an effort to quantify extremely low curcumin plasma concentrations observed in preliminary in vivo studies. the most sensitive as ... | 2003 | 14581073 |
| curcumin inhibits protease-activated receptor-2 and -4-mediated mast cell activation. | curcumin, a major yellow pigment and active component of turmeric powder extracted from curcuma longa l. (gingiberaceae), has been shown to possess anti-inflammatory and anti-cancer activities. protease-activated receptors (pars) play a role in inflammation, and human leukemic mast cells (hmc-1) co-express par2 and par4. in the present study, the effect of curcumin on par2- and par4-mediated hmc-1 activation was examined. | 2003 | 14637278 |
| repellency of aromatic turmeric curcuma aromatica under laboratory and field conditions. | three curcuma species, curcuma aeruginosa (pink and blue ginger), cu. aromatica (aromatic turmeric), and cu. xanthorrhiza (giant curcuma), were selected for investigation of mosquito repellent activity. in a laboratory study, a 95% ethanol extract of each plant was tested for repellent activity of aedes togoi on human volunteers. only cu. aromatica extract showed repellency against ae. togoi with ed50 and ed95 values of 0.061 and 1.55 mg/cm2, respectively. it also provided biting protection for ... | 2003 | 14714673 |
| protective effect of curcumin against lead neurotoxicity in rat. | curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. the present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (lpo) and a decrease in reduced glutathione (gsh) levels in cerebellum ... | 2003 | 14992327 |
| curcumin as a dna topoisomerase ii poison. | curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. it induces apoptosis, but its initiation mechanism remains poorly understood. curcumin has been assessed on the human cancer cell lines, tk-10, mcf-7 and uacc-62, and their ic50 values were 12.16, 3.63, 4.28 microm respectively. the possibility of this compound being a topoisomerase ii poison has also been studied and it was found that 5 ... | 2003 | 15008515 |
| suppression by hydrangeae dulcis folium of d-galactosamine-induced liver injury in vitro and in vivo. | hydrangeae dulcis folium, the fermented and dried leaves of hydrangea macrophylla ser. var. thunbergii makino, suppressed d-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. the hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. some fractionated extracts showed hepatoprotective activity in the d-galactosamine-induced in vitro liver injury model. | 2003 | 14730144 |
| early human safety study of turmeric oil (curcuma longa oil) administered orally in healthy volunteers. | turmeric extract and turmeric oil have shown chemoprotective effect against chemically-induced malignancies in experimental animals. they can reverse precancerous changes in oral submucous fibrosis in humans. the use of turmeric or curcuma longa linn as a spice and household remedy has been known to be safe for centuries. in view of the long term administration required for cancer prevention a phase i clinical trial of turmeric oil (to) was designed to study the safety and tolerance of to in vol ... | 2003 | 15260388 |
| curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in lncap prostate cancer cells. | the role of natural food products in prevention of prostate cancer has been confirmed in recent epidemiological studies; however, the mechanism of chemoprevention by the dietary constituents largely remains unknown. curcumin, the yellow pigment and active component of turmeric (curcuma longa), exhibits chemopreventive and growth inhibitory activity against several tumor cell lines. the androgen-sensitive human prostate cancer cell line lncap is only slightly susceptible to tumor necrosis factor- ... | 2003 | 12533677 |
| inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats. | turmeric, widely used in food and medicine has been shown to prevent benzo(a)pyrene [b(a)p] or dimethylbenz(a)anthracene (dmba)-induced forestomach, skin and mammary tumors in mice and/or rats. in this study we examine the modulatory effects of turmeric on nitrosodiethylamine (ndea)-induced hepatocarcinogenesis in rats. female wistar rats were administered ndea (200 ppm) through drinking water (5 days per week) for 4 weeks. control and/or ndea-treated rats received 0, 0.2, 1.0 or 5.0% turmeric d ... | 2003 | 12595157 |
| curcumin differentially modulates mrna profiles in jurkat t and human peripheral blood mononuclear cells. | curcumin, the yellow pigment of the rhizome of curcuma longa is known to inhibit the transcription factors ap-1, egr-1, nf-kappab, c-myc and several important signaling kinases. we therefore investigated the differential effects of curcumin in concentation between 1.5 and 13.6 microm on gene expression in t jurkat cd4(+) and human peripheral blood mononuclear cells (pbmcs). relative quantification with reverse transcription real-time pcr (rt-rt-pcr) showed that low concentrations of curcumin sig ... | 2003 | 12614893 |
| hepatobiliary clearance of labelled mebrofenin in normal and d-galactosamine hcl-induced hepatitis rats and the protective effect of turmeric extract. | this study was carried out to see the hepatobiliary clearance of 99m tc-mebrofenin radiopharmaceutical in d-galactosamine induced hepatic rats. furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. hepatitis was induced with intraperitoneal injection of d-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. turmeric extract treatment significantly increased the hepatic uptake of radioactivity ... | 2003 | 14723320 |
| curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. | curcumin (cur), the active chemical of the asian spice turmeric, has strong anti-oxidant and anti-inflammatory properties. cur inhibits proliferation and growth of several cell types, e.g. cancer cells. while cur inhibitory effects on microglial cells are demonstrated, little is known of its effects on neuroglia, astrocytes (ast) and oligodendrocytes (olg). our work focuses on cur's effects on neuroglial proliferation and growth in vitro, utilizing c-6 rat glioma 2b-clone cells, a mixed colony o ... | 2003 | 15073579 |
| plant medicines of indian origin for wound healing activity: a review. | research on wound healing drugs is a developing area in modern biomedical sciences. scientists who are trying to develop newer drugs from natural resources are looking toward the ayurveda, the indian traditional system of medicine. several drugs of plant, mineral, and animal origin are described in the ayurveda for their wound healing properties under the term vranaropaka. most of these drugs are derived from plant origin. some of these plants have been screened scientifically for the evaluation ... | 2003 | 15866825 |
| effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. | baicalein, berberine, curcumin and hesperidin are the major components derived from scutellaria baicalensis, coptis japonica, curcuma longa and poncirus trifoliata, respectively. these plants have been used for the treatment of diverse chronic inflammatory diseases including respiratory disease in oriental medicine and their respective major components were reported to have various biological effects including anti-inflammatory activity. in the present study, we investigated whether these four n ... | 2003 | 12865970 |
| curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of nm23 and e-cadherin. | curcumin (diferuloyl methane), the major pigment from the rhizome of curcuma longa l., has been widely studied for its tumor-inhibiting properties. recent studies indicate that curcumin can modify cell receptor binding, it also affects intracellular signalling reactions. curcumin-treated b16f10 melanoma cells formed eight-fold fewer lung metastases in c57bl6 mice. in the cell adhesion assays, curcumin-treated cells showed a dose-dependent reduction in their binding to four extracellular matrix ( ... | 2003 | 12678405 |
| in vitro curcumin modulates ferric nitrilotriacetate (fe-nta) and hydrogen peroxide (h2o2)-induced peroxidation of microsomal membrane lipids and dna damage. | a number of investigations have implicated the involvement of free radicals in various pathogenic process including initiation/promotion stages of carcinogenesis and antioxidants have been considered to be a protective agent for this reason. an iron chelate, ferric nitrilotriacetate (fe-nta), is a potent nephrotoxic agent and induces acute and subacute renal proximal tubular necrosis by catalyzing the decomposition of hydrogen peroxide-derived production of hydroxyl radicals, which are known to ... | 2003 | 12616605 |
| alternative treatment of gallbladder disease. | major risk factors for gallbladder disease include a sedentary lifestyle and a diet rich in refined sugars. in genetically prone individuals, these two factors lead to an abnormal bile composition, altered gut microflora, and hyperinsulinemia, with resulting gallstone formation. as a large percentage of gallbladder patients have continued digestive complaints following cholecystectomy, the author examines complementary and alternative medicine (cam) treatments to counteract gallstone formation. ... | 2003 | 12450782 |
| curcumin in plasma and urine: quantitation by high-performance liquid chromatography. | curcumin, a derivative of the plant curcuma longa, is used extensively in the food industry. it is a major component of curry powder, and research has shown that curcumin may prevent cancer and other chronic diseases. we have developed a robust automated analytical method for the determination of curcumin in plasma and urine. the method involves extracting the curcumin from 0.2 ml sample volume with ethyl acetate/methanol organic solvents, and use of an internal standard, beta-17-estradiol aceta ... | 2003 | 12450549 |
| redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach. | oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. alzheimer's disease (ad) is a progressive disorder with cognitive and memory decline, speech loss, personality changes and synapse loss. many approaches have been undertaken to understand ad, but the heterogeneity of the etiologic factors makes it difficult to define the clinically most important factor determining the onset and progression of the disease. however, incr ... | 2003 | 14661103 |
| curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. | there is evidence for increased levels of circulating reactive oxygen species (ros) in diabetics, as indirectly inferred by the findings of increased lipid peroxidation and decreased antioxidant status. direct measurements of intracellular generation of ros using fluorescent dyes also demonstrate an association of oxidative stress with diabetes. although phenolic compounds attenuate oxidative stress-related tissue damage, there are concerns over toxicity of synthetic phenolic antioxidants and th ... | 2003 | 14660871 |
| biomimetic oxidation of curcumin with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(iii) chlorides in dichloromethane. | the biomimetic oxidation of curcumin, a main turmeric pigment with hydrogen peroxide catalyzed by different 5,10,15,20-tetraarylporphyrinatoiron(iii) chlorides [tapfe(iii)cl] in dichloromethane has been studied to give a c-c coupled curcumin dimer in 40-70% yield. the structure of the dimer has been elucidated by (1)h-, (13)c-nmr, ir and fab-mass spectroscopic data. | 2003 | 14600390 |
| nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in alzheimer's disease. | oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. alzheimer's disease (ad) is a progressive disorder with cognitive and memory decline, speech loss, personality changes and synapse loss. many approaches have been undertaken to understand ad, but the heterogeneity of the etiologic factors makes it difficult to define the clinically most important factor determining the onset and progression of the disease. however, incr ... | 2003 | 15141484 |
| extraction of essential oil and pigments from curcuma longa [l] by steam distillation and extraction with volatile solvents. | curcuma longa [linn] (turmeric), of the zingiberaceae family, has a great importance in the food, textile, and pharmaceutical industries. the aim of this work was to identify the best processing conditions to maximize the yields of essential oil and pigments, as well as their content of ar-turmerone, (alpha and beta)-turmerone, and the curcuminoids, respectively. autoclave pressure and distillation time were the variables studied for the steam distillation process. the highest yields of essentia ... | 2003 | 14582978 |
| comparison of yield, composition, and antioxidant activity of turmeric (curcuma longa l.) extracts obtained using various techniques. | turmeric extracts were obtained from two lots of raw material (m and s) using various techniques: hydrodistillation, low pressure solvent extraction, soxhlet, and supercritical extraction using carbon dioxide and cosolvents. the solvents and cosolvents tested were ethanol, isopropyl alcohol, and their mixture in equal proportions. the composition of the extracts was determined by gas chromatography-flame ionization detection (gc-fid) and uv. the largest yield (27%, weight) was obtained in the so ... | 2003 | 14558784 |
| evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. | the plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (no) levels using sodium nitroprusside as a no donor in vitro. most of the extracts tested demonstrated direct scavenging of no and exhibited significant activity and the potency of scavenging activity was in the following order: foeniculum vulgare (aqueous) > citrus limettiodes > murraya koenigii (seed, aqueous) > murraya koenigii (leaf, aqueous) > curcuma aromatica (aqueous) > mur ... | 2003 | 13678266 |
| high-frequency shoot multiplication in curcuma longa l using thidiazuron. | the effects of plant growth regulators, explant types, and culture regimens were investigated on in vitro shoot proliferation from terminal bud explants of curcuma longa. each bud was longitudinally divided into four equal pieces, each 1 cm in length, and used as explants. these were then cultured on ms medium supplemented with 18.17 microm thidiazuron for 4 weeks prior to transfer to ms medium without growth regulator for 8 weeks. under these conditions, a shoot induction rate of 18.22+/-0.62 s ... | 2003 | 12835998 |
| dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. | keloid and hypertrophic scars commonly occur after injuries. overproliferation of fibroblasts, overproduction of collagen, and contraction characterize these pathologic scars. current treatment of excessive scars with intralesional corticosteroid injections used individually or in combination with other methods often have unsatisfactory outcome, frustrating both the patient and the clinician. the phytochemical compounds are well known as potential anticancer agents. we have investigated the inhi ... | 2003 | 12813346 |
| exploration of melt granulation technique for the development of coprocessed directly compressible adjuvant containing lactose and microcrystalline cellulose. | the objective of the present investigation was to prepare and evaluate lactose and microcrystalline cellulose based, directly compressible adjuvant using melt granulation technique. the percentage of polymer blend (pvp k 30 and peg 4000; 5, 10, or 15%) and the polymer blend ratio (9:1, 1:1, or 1:9) were selected as independent variables in a 3(2) full factorial design. the lactose and microcrystalline cellulose blend (3:1) was mixed with the meltable binder on a water bath at 90 degrees c. the a ... | 2003 | 12760568 |
| in vitro peroxynitrite scavenging activity of diarylheptanoids from curcuma longa. | peroxynitrite is a cytotoxic intermediate produced by the reaction between the superoxide anion (o(2)) and nitric oxide (no). the aim of this study was to investigate the scavenging effects of curcuma longa l. on authentic peroxynitrite, and further studies are planned that will attempt to identify the active principles from the active fractions. the methanolic extract of c. longa showed 50% scavenging activity (ic(50)) at concentration of 1.7 +/- 0.08 micro g/ml, and was thus fractionated with ... | 2003 | 12748983 |
| cytoprotective and cytotoxic effects of curcumin: dual action on h2o2-induced oxidative cell damage in ng108-15 cells. | the ability of curcumin, a natural antioxidant isolated from curcuma longa, to inhibit hydrogen peroxide (h(2)o(2))-induced cell damage in ng108-15 cells was examined. when added simultaneously with 500 microm h(2)o(2), curcumin (25-100 microm) effectively protected cells from oxidative damage. however, when the cells were pretreated with curcumin (25-100 microm) for 1.5 h before h(2)o(2) exposure, curcumin was unable to inhibit h(2)o(2)-induced cell damage. instead, it caused a significant conc ... | 2003 | 12736521 |
| dietary supplementation of curcumin enhances antioxidant and phase ii metabolizing enzymes in ddy male mice: possible role in protection against chemical carcinogenesis and toxicity. | dietary antioxidants protect laboratory animals against the induction of tumours by a variety of chemical carcinogens. among possible mechanism of protection against chemical carcinogenesis could be mediated via-antioxidant-dependent induction of detoxifying enzymes. curcumin, a yellow pigment from curcuma longa, is a major component of turmeric and is commonly used as a spice and food colouring material and exhibits antiinflammatory antitumour, and antioxidant properties. in this study we there ... | 2003 | 12710595 |
| bulk and trace element analysis of spices: the applicability of k0-standardization and energy dispersive x-ray fluorescence. | methodology has been developed for the bulk and trace element analysis of spices such as curry powder and turmeric powder originated from sri lanka by the k0-standardization method (inaa-k0) and by energy dispersive x-ray fluorescence (edxrf). srm 1572 citrus leaves was used to check the accuracy of the results obtained by the two nuclear techniques. the elements determined quantitatively in these matrices by the edxrf analysis were bromine, calcium, copper, iron, potassium, magnesium, manganese ... | 2004 | 15139383 |
| biological properties of curcumin-cellular and molecular mechanisms of action. | curcuminoids, a group of phenolic compounds isolated from the roots of curcuma longa (zingiberaceae), exhibit a variety of beneficial effects on health and on events that help in preventing certain diseases. a vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcuminoid. the most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities. in addition, the wound healing and ... | 2004 | 15116757 |
| effect of curcumin on radiation-impaired healing of excisional wounds in mice. | to study the effect on wound contraction of pretreatment with various doses of curcumin (the most important active ingredient of the spice turmeric) in mice exposed to 6 gy whole-body gamma radiation. | 2004 | 15045805 |
| curcumin confers radiosensitizing effect in prostate cancer cell line pc-3. | curcumin (diferuloylmethane) is a major chemical component of turmeric (curcuma longa) and is used as a spice to give a specific flavor and yellow color in asian food. curcumin exhibits growth inhibitory effects in a broad range of tumors as well as in tpa-induced skin tumors in mice. this study was undertaken to investigate the radiosensitizing effects of curcumin in p53 mutant prostate cancer cell line pc-3. compared to cells that were irradiated alone (sf(2)=0.635; d(0)=231 cgy), curcumin at ... | 2004 | 14985701 |
| laccur stain for detection of mucin in adenocarcinoma. | identification of cytoplasmic mucin, usually by mayer's mucicarmine stain, is one of the criteria to diagnose adenocarcinoma. the inexpensive laccur stain, made up of curcuma longa (khamin-shan) and secreta of laccifer lacca (krang) has been introduced. the aim of this study was to compare the mayer's mucicarmine and laccur stains in the detection of mucin material. the specimens included 17 adenocarcinomas of the stomach, 16 of the colon, 18 of the lung, 16 of the breast, and 12 of the bile duc ... | 2004 | 14971540 |
| application of single-nucleotide polymorphism analysis of the trnk gene to the identification of curcuma plants. | we previously found that curcuma plants and drugs derived from curcuma longa, c. phaeocaulis, c. zedoaria, and c. aromatica could be identified by the nucleotide differences at two sites and the existence of a 4-base indel on trnk gene. in this paper, based on species-specific nucleotide sequences, the application of a new method, single-nucleotide polymorphism (snp) analysis was investigated to identify curcuma plants more conveniently. first, three types of reverse primer were synthesized in d ... | 2004 | 14709921 |
| [preparative separation of curcumin from turmeric by column chromatography]. | 2004 | 15709435 | |
| turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. | to assess the effects of turmeric (curcuma longa) extract on irritable bowel syndrome (ibs) symptomology in otherwise healthy adults. | 2004 | 15673996 |
| immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. | curcumin (diferuloylmethane), a major curcumanoid found in the spice turmeric, exhibits anti-inflammatory, anti-oxidant, and chemopreventive activities. however, the effect of curcumin on the development of t cell-mediated immunological responses largely remains unknown. in this study we have investigated the effect of curcumin on mitogen/antigen induced proliferation of splenic lymphocytes, induction of cytotoxic t lymphocytes (ctls), lymphokine activated killer (lak) cells, and the production ... | 2004 | 15183117 |
| patented antiinflammatory plant drug development from traditional medicine. | patents secured on antiinflammatory plant drugs derived from 38 plants are reviewed. an attempt has been made to compare the modern and traditional use of plant drugs and to establish the relevance of folk claims in developing modern drugs. the role of plant botanicals such as polysaccharides, terpenes, curcuminoids, alkaloids, etc. in alleviating inflammatory diseases including arthritis, rheumatism, acne skin allergy and ulcers is highlighted. chemicals that alleviate swelling are derived from ... | 2004 | 15173991 |
| role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation. | the healing of irradiated wounds has always been a central consideration in medical practice because radiation disrupts normal response to injury, leading to a protracted recovery period. the quest for clinically effective wound healing agents is important in the medical management of irradiated wounds. therefore, the present study was conceptualized to investigate the effect of curcumin (natural yellow, diferuloylmethane), a major yellow pigment and an active component of turmeric on wound heal ... | 2004 | 15172199 |
| a 32-week randomized, placebo-controlled clinical evaluation of ra-11, an ayurvedic drug, on osteoarthritis of the knees. | the ancient indian (asian) ayurvedic medicinal system uses herbomineral drugs to treat arthritis. despite centuries of use, very few have been tested by drug trials. ra-11 (artrex, mendar), a standardized multiplant ayurvedic drug (withania somnifera, boswellia serrata, zingiber officinale, and curcuma longa) is currently used to treat arthritis. | 2004 | 17043520 |
| [study on the sfe condition for curcumin in curcuma longa]. | to optimize the conditions of supercritical fluid extraction (sfe) for curcumin in curcuma longa. | 2004 | 15575202 |
| some like it hot: curcumin and cftr. | the activation of mutant forms of the cystic fibrosis transmembrane conductance regulator (cftr), particularly the most frequent mutant allele (deltaf508), is a potential strategy for the treatment of the disease cystic fibrosis (cf). therefore, it is of great interest that curcumin, a component of the spice turmeric, is reported to restore function to this allele, both in heterologous expression systems and in deltaf508 cf mice. although other laboratories have not been able to confirm the init ... | 2004 | 15464445 |
| curcumin interaction with copper and iron suggests one possible mechanism of action in alzheimer's disease animal models. | curcumin is a polyphenolic diketone from turmeric. because of its anti-oxidant and anti-inflammatory effects, it was tested in animal models of alzheimer's disease, reducing levels of amyloid and oxidized proteins and preventing cognitive deficits. an alternative mechanism of these effects is metal chelation, which may reduce amyloid aggregation or oxidative neurotoxicity. metals can induce abeta aggregation and toxicity, and are concentrated in ad brain. chelators desferrioxamine and clioquinol ... | 2004 | 15345806 |
| sulfur free radical reactivity with curcumin as reference for evaluating antioxidant properties of medicinal zingiberales. | rhizome extracts of some members of the medicinal zingiberales are widely used in dietary intake as well as in the traditional system of medicine. curcumin, the chrome orange-yellow coloring compound present in turmeric rhizomes, has long been known to possess antioxidant property. crude methanol extracts of the rhizomes of 11 species--alpinia allughas, a. galanga, curcuma amada, c. caesia, c. leucorrhiza, hedychium coronarium, h. coccineum, h. flavescens, kaempferia galanga, zingiber cassumunar ... | 2004 | 15312045 |
| mining medline for implicit links between dietary substances and diseases. | text mining systems aim at knowledge discovery from text collections. this work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. in particular, we use it to discover novel uses for curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in asia. | 2004 | 15262811 |
| interventions in aging and age-associated pathologies by means of nutritional approaches. | so-called antioxidant strategies have not been shown convincingly to be effective in increasing life spans of animals. thus, the general consensus of experimental gerontology in the last century was that the only reproducible means of prolonging survivals of animals is the calorie restriction paradigm. as a challenge against this dogma, we attempted to examine the effect of two potent antioxidants, one tetrahydrocurcumin (a biotransformed metabolite of curcumin contained in turmeric of indian cu ... | 2004 | 15247057 |
| in vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. | curcumin, the active ingredient from the spice turmeric (curcuma longa linn), is known to be an anti-oxidant and an anti-inflammatory agent. it has been demonstrated recently to possess anti-angiogenic effects and pro-apoptotic activities against ehrlich ascites tumor cells. in the current study, curcumin was found to be cytotoxic in vitro for b16-r melanoma cells resistant to doxorubicin either cultivated as monolayers or grown in three-dimensional (3-d) cultures (spheroids). we have demonstrat ... | 2004 | 15221965 |
| modulation of human multidrug-resistance mdr-1 gene by natural curcuminoids. | multidrug resistance (mdr) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. it is related to the overexpression of a membrane protein, p-glycoprotein (pgp-170), thereby reducing drug cytotoxicity. a variety of studies have tried to find mdr modulators which increase drug accumulation in cancer cells. | 2004 | 15090070 |
| anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma a431 cells. | photodynamic treatment (pdt) can elicit a diverse range of cellular responses, including apoptotic cell death. previously, we showed that pdt stimulates caspase-3 activation and subsequent cleavage and activation of p21-activated kinase 2 (pak2) in human epidermal carcinoma a431 cells. curcumin, the yellow pigment of curcuma longa, is known to have anti-oxidant and anti-inflammatory properties. in the present study, using rose bengal (rb) as the photosensitizer, we investigated the effect of cur ... | 2004 | 15095415 |
| curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. | cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (cftr). the most common mutation, deltaf508, results in the production of a misfolded cftr protein that is retained in the endoplasmic reticulum and targeted for degradation. curcumin is a nontoxic ca-adenosine triphosphatase pump inhibitor that can be administered to humans safely. oral administration of curcumin to homozygous deltaf508 cftr mice in doses comparable, on a weight-p ... | 2004 | 15105504 |
| spice phenolics inhibit human pmnl 5-lipoxygenase. | a wide variety of phenolic compounds and flavonoids present in spices possess potent antioxidant, antimutagenic and anticarcinogenic activities. we examined whether 5-lipoxygenase (5-lo), the key enzyme involved in biosynthesis of leukotrienes is a possible target for the spices. effect of aqueous extracts of turmeric, cloves, pepper, chili, cinnamon, onion and also their respective active principles viz., curcumin, eugenol, piperine, capsaicin, cinnamaldehyde, quercetin, and allyl sulfide were ... | 2004 | 15120715 |
| curcumin (diferuloylmethane) inhibits receptor activator of nf-kappa b ligand-induced nf-kappa b activation in osteoclast precursors and suppresses osteoclastogenesis. | numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with cancers and other diseases. gene deletion studies have shown that receptor activator of nf-kappab ligand (rankl) is one of the critical mediators of osteoclastogenesis. how rankl mediates osteoclastogenesis is not fully understood, but an agent that suppresses rankl signaling has potential to inhibit osteoclastogenesis. in this rep ... | 2004 | 15128775 |
| modulatory properties of various natural chemopreventive agents on the activation of nf-kappab signaling pathway. | to study and compare effects of selected natural chemopreventive agents on the transcription activation of nuclear factor-kappa b (nf-kappab) in human ht-29 colon cancer cells. | 2004 | 15139523 |
| induction of apoptosis in human lung cancer cells by curcumin. | curcumin, a phenolic compound from the rhizome of the plant curcuma longa has anti-inflammatory, antioxidant and anti-cancer activities. although the precise mode of action of this compound is not yet elucidated, studies have shown that chemo-preventive action of curcumin might be due to its ability to induce apoptosis and to arrest cell cycle. this study investigated the cellular and molecular changes induced by curcumin leading to the induction of apoptosis in human lung cancer cell lines-a549 ... | 2004 | 15142674 |
| antimutagenicity of herbal detoxification formula smoke shield against environmental mutagens. | smoke shield is a formulation designed to reduce smoke related mutagenicity and toxicity in the population. smoke shield contains a dual extract of turmeric (curcuma longa) obtained by supercritical co2 gas extraction and post-supercritical hydroethanolic extraction together with extracts of green tea and other spices, whose presence synergistically increases the activity of turmeric. in the present study we have shown its antimutagenic activity to various environmental mutagens in vitro and in ... | 2004 | 15149152 |
| antimicrobial and chemopreventive properties of herbs and spices. | herbs and spices have been used for generations by humans as food and to treat ailments. scientific evidence is accumulating that many of these herbs and spices do have medicinal properties that alleviate symptoms or prevent disease. a growing body of research has demonstrated that the commonly used herbs and spices such as garlic, black cumin, cloves, cinnamon, thyme, allspices, bay leaves, mustard, and rosemary, possess antimicrobial properties that, in some cases, can be used therapeutically. ... | 2004 | 15180577 |
| curcumin blocks multiple sites of the tgf-beta signaling cascade in renal cells. | over-expression of transforming growth factor-beta (tgf-beta) contributes greatly to fibrotic kidney disease. the activator protein-1 (ap-1) inhibitor curcumin, a polyphenolic compound derived from curcuma longa, has been shown to reduce collagen accumulation in experimental pulmonary fibrosis. here, we investigate curcumin's ability to modulate tgf-beta's profibrotic actions in vitro. | 2004 | 15200418 |
| ectopic expression of bcl-xl or ku70 protects human colon cancer cells (sw480) against curcumin-induced apoptosis while their down-regulation potentiates it. | curcumin, the yellow pigment derived from curcuma longa, is known to induce apoptosis of several cancer cells. however, many cancer cells protect themselves by over-expressing antiapoptotic proteins such as bcl-xl or ku70. to study their role in curcumin-induced apoptosis, human colon cancer cells (sw480) were made to over-express or under-express bcl-xl (by stable transfection) and ku70 (by transient transfection) using plasmid constructs that express their genes in sense or antisense orientati ... | 2004 | 15205359 |
| inhibitory activity of diarylheptanoids on farnesyl protein transferase. | diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-o-methyl)curcumin (5)] were isolated from the methanolic extract of curcuma longa l. and a new cyclic diarylheptanoid (6) and a known compound 7 were isolated from fruits of alnus japonica steud. diarylheptanoids (1-3) inhibited farnesyl protein transferase (fptase) with an ic50 of 29-50 microm. the other compounds very mildly inhibited fptase, therefore, the inh ... | 2004 | 15214479 |
| indian food ingredients and cancer prevention - an experimental evaluation of anticarcinogenic effects of garlic in rat colon. | the major food items of indian cuisine include rice, wheat, diary products, and abundant fruits and vegetables. beside these, there are several kinds of herbs and spices as important ingredients, containing many phytochemicals with medicinal properties, adding taste to indian cuisine. an impressive body of data exists in support of the concept that indian food ingredients can be used in preventive strategies aimed at reducing the incidence and mortality of different types of cancers because of t ... | 2004 | 15244513 |
| curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/apo2l by inhibiting nuclear factor-kappab through suppression of ikappabalpha phosphorylation. | epidemiologic studies suggest that diet rich in plant-derived foods plays an important role in the prevention of prostate cancer. curcumin, the yellow pigment in the spice turmeric, has been shown to exhibit chemopreventive and growth inhibitory activities against multiple tumor cell lines. we have shown previously that curcumin and tumor necrosis factor-related apoptosis-inducing ligand (trail)/apo2l interact to induce cytotoxicity in the lncap prostate cancer cell line. in this study, we inves ... | 2004 | 15252141 |
| induction of apoptosis by ar-turmerone on various cell lines. | this study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (curcuma longa l) on the k562, l1210, u937 and rbl-2h3 cell lines by the mtt assay. ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. the ic50 values of ar-turmerone on these cell lines were 20-50 microg/ml. they showed an increased inhibition ratio on cell viability according to the drug concentration < or = 80 microg/ml in the cell lines tested. the dna fragmentation that is a characteristi ... | 2004 | 15254774 |
| curcumin induces c-jun n-terminal kinase-dependent apoptosis in hct116 human colon cancer cells. | curcumin, the major pigment of the dietary spice turmeric has the potential for chemoprevention by promotion of apoptosis. mitogen-activated protein kinase (mapk) and nf-kappa b (nfkappab) signalling cascades are thought to regulate apoptosis and cell survival. while curcumin inhibits nfkappab, its effects upon the mapk pathways are unclear. this study investigates curcumin effects upon mapk signalling and apoptosis in hct116 cells. here we report that curcumin time- and dose-dependent induction ... | 2004 | 15256484 |
| antioxidant effect of curcumin in selenium induced cataract of wistar rats. | wistar rat pups treated with curcumin, a natural constituent of curcuma longa before being administered with selenium showed no opacities in the lens. the lipid peroxidation, xanthine oxidase enzyme levels in the lenses of curcumin and selenium co-treated animals were significantly less when compared to selenium treated animals. the superoxidase dismutase and catalase enzyme activities of curcumin and selenium co-treated animal lenses showed an enhancement. curcumin co-treatment seems to prevent ... | 2004 | 15260112 |
| through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. | curcumin, the major constituent of turmeric is a known, naturally occurring antioxidant. the present study examined the ability of this compound to protect against lead-induced damage to hippocampal cells of male wistar rats, as well as lipid peroxidation induced by lead and cadmium in rat brain homogenate. the thiobarbituric assay (tba) was used to measure the extent of lipid peroxidation induced by lead and cadmium in rat brain homogenate. the results show that curcumin significantly protects ... | 2004 | 14729307 |
| inhibition of b(a)p induced strand breaks in presence of curcumin. | incidence of cancer at different sites may be related to oxidative damage to host genome by genotoxicants. these oxidative actions may be modified by phytochemicals present in foods. the non-nutritive dietary constituents which possess antimutagenic property appear to be promising chemopreventive agents. this study reports the protective effect of curcumin on b(a)p induced dna damage in human peripheral blood lymphocyte cells. the study group consisted of 10 male smokers, 10 non-smokers and 10 n ... | 2004 | 14729375 |
| protective effects of curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. | the present study was undertaken to evaluate the cardioprotective potential of curcuma longa (turmeric) in the ischemia-reperfusion (i/r) model of myocardial infarction (mi). wistar rats were divided into three groups and received saline orally (sham, control i/r group) and curcuma longa 100 mg/kg (cl-100 treated group) respectively for one month. on the 31st day, rats of the control i/r and cl treated groups were subjected to 45 min of occlusion of the lad coronary artery and were thereafter re ... | 2004 | 15268970 |
| evidence against the rescue of defective deltaf508-cftr cellular processing by curcumin in cell culture and mouse models. | curcumin, the yellow colored component of the spice turmeric, has been reported to rescue defective deltaf508-cystic fibrosis transmembrane conductance regulator (cftr) cellular processing in homozygous mutant mice, restoring nasal potential differences and improving survival (egan, m. e., pearson, m., weiner, s. a., rajendran, v., rubin, d., glockner-pagel, j., canny, s., du, k., lukacs, g. l., and caplan, m. j. (2004) science 304, 600-602). because of the implied potential use of curcumin or s ... | 2004 | 15280357 |
| curcumin-induced apoptosis in scleroderma lung fibroblasts: role of protein kinase cepsilon. | scleroderma, a disease involving excessive collagen deposition, can be studied using fibroblasts cultured from affected tissues. we find that curcumin, the active component of the spice turmeric, causes apoptosis in scleroderma lung fibroblasts (slf), but not in normal lung fibroblasts (nlf). this effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione s-transferase p1 (gst p1) in nlf, slf are ... | 2004 | 14742295 |
| curcumin blocks nf-kappab and the motogenic response in helicobacter pylori-infected epithelial cells. | infection of epithelial cells by the microbial pathogen helicobacter pylori leads to activation of the transcription factor nuclear factor kappab (nf-kappab), the induction of pro-inflammatory cytokine/chemokine genes, and the motogenic response (cell scattering). here we report that h. pylori-induced nf-kappab activation and the subsequent release of interleukin 8 (il-8) are inhibited by curcumin (diferuloylmethane), a yellow pigment in turmeric (curcuma longa l.). our results demonstrate that ... | 2004 | 15044093 |
| contraceptive effect of curcuma longa (l.) in male albino rat. | to study the contraceptive effect of the crude extracts of curcuma longa in male albino rats. | 2004 | 15064838 |
| a water extract of curcuma longa l. (zingiberaceae) rescues pc12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in pc12 cells. | a number of studies indicate that free radicals are involved in the neurodegeneration in alzheimer's disease (ad). the role of superoxide anion (o2*-) in neuronal cell injury induced by reactive oxygen species (ros) was examined in pc12 cells using pyrogallol (1,2,3-benzenetrior), a donor to release o2*-. pyrogallol induced pc12 cell death at concentrations, which evidently increased intracellular o2*-, as assessed by o2*- sensitive fluorescent precursor hydroethidine (het). a water extract of c ... | 2004 | 15350833 |
| comparative effects of curcumin and an analog of curcumin on alcohol and pufa induced oxidative stress. | alcoholic liver disease is a major medical complication of alcohol abuse and a common liver disease in western countries. increasing evidence demonstrates that oxidative stress plays an important etiologic role in the development of alcoholic liver disease. alcohol alone or in combination with high fat is known to cause oxidative injury. the present study therefore aims at evaluating the protective role of curcumin, an active principle of turmeric and a synthetic analog of curcumin (ca) on alcoh ... | 2004 | 15367386 |
| effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. | curcumin, a well-known dietary pigment derived from curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. however, its mechanism of action still remains unclear. in this study, we have focused primarily on the cytotoxic effects of curcumin on three human tumor cell lines and rat primary hepatocytes. curcumin induced apoptosis in mcf-7, mdamb, and hepg2 cells in a dose-dependent and time-dependent manner. apoptosis was mediated through the generation of re ... | 2004 | 15367704 |
| curcumin, a novel p300/creb-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. | acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral dna that integrates into the human genome (e.g. the human immunodeficiency virus). dysfunction of histone acetyltransferases (hats) is often associated with the manifestation of several diseases. in this respect, hats are the new potential targets for the design of therapeutics. in this study, we report that curcumin (diferuloy ... | 2004 | 15383533 |
| evaluation of dna damage in mice topically exposed to total particulate matter from mainstream and sidestream smoke from cigarettes and bidis. | the genotoxic potential of total particulate matter (tpm) from mainstream smoke (ms) and sidestream smoke (ss) of indian smoking products, namely cigarettes and bidis, as well as a brand of us cigarettes, was studied by determining the levels of bulky aromatic dna adducts in mouse tissues. tpm from ms or ss of various smoking products [equal weights (2.5 mg) or the amount derived from equal (0.25) cigarette/bidi] was applied topically to mouse skin once a day for four consecutive days and adduct ... | 2004 | 15388816 |