Publications

blockade of the oestrogen-induced lh surge in the ovariectomized common marmoset (callithrix jacchus) by an lhrh antagonist.	six long-term ovariectomized adult marmoset monkeys were treated at 0 h with 35 micrograms oestradiol benzoate s.c. to induce an lh surge. they were also treated with detirelix (an lhrh antagonist) at 0 h, 12 h and 24 h (exp. 1), or at 0 h and 24 h (exp. 2) at a dose of 300 micrograms/kg s.c., or received the detirelix vehicle alone at 0 h, 12 h and 24 h (exp. 3). all animals received the three treatments, with at least 4 weeks between experiments. blood samples were collected at 0 h and at 6-12 ...	1989	2539474
changing responsiveness of luteal cells of the marmoset monkey (callithrix jacchus) to luteotrophic and luteolytic agents during normal and conception cycles.	dispersed marmoset luteal cells were incubated for 2 h and progesterone production measured after exposure to hcg, cloprostenol, dibutyryl camp, pgf-2 alpha, pgf-2, adrenaline or melatonin. the cells were studied on days 6, 14 and 20 after ovulation in conception and non-conception cycles. luteal cells from day 14 non-pregnant marmosets were compared with human luteal cells taken in the mid-luteal phase. all the treatments stimulated progesterone production including cloprostenol, which is luteo ...	1989	2560061
tissue specific differences in the fatty acid composition of the marmoset monkey (callithrix jacchus).	1. the possible relationship between the fatty acid composition of the adipose tissue of the marmoset monkey (callithrix jacchus) and its dietary lipid intake was examined after a long-term feeding trial. 2. only the proportions of stearic and linoleic acid in the adipose tissue were similar to those in the diet. the proportions of all other saturated and unsaturated fatty acid components were significantly different thus greatly reducing the potential value of this relationship in the marmoset. ...	1989	2565781
stereoselective reversal of mptp-induced parkinsonism in the marmoset after dermal application of n-0437.	the selective dopamine d-2 receptor agonist n-0437 produced a rapid and dose-dependent reversal of motor deficits lasting 90-120 min following i.p. or oral administration of the racemate to mptp-treated common marmosets. in contrast, topical application of (+/-)-, (+)- or (-)-n-0437 to the skin of mptp-treated animals did not alter locomotor activity in the initial 4 h although other motor disabilities were reduced. however, 24 h following application of the racemate or the (-) enantiomer both l ...	1989	2572426
desenkephalin-gamma-endorphin is an antagonist of the hyperactivity response induced by infusion of dopamine into the nucleus accumbens of rat and ventral striatum of marmoset.	the ability of desenkephalin-gamma-endorphin (de gamma e; org5878) to antagonise a raised limbic dopamine function was investigated in the rat and common marmoset. dopamine was infused for 13 days directly into the nucleus accumbens of the rat and ventral striatum of the marmoset and increased locomotor activity. such increases in both the rat and marmoset were antagonised by the subcutaneous injection of de gamma e, administered in a range 10-500 micrograms/kg (t.i.d.), during the 13 day period ...	1989	2574424
in vivo formation of metabolites of prostaglandins i2 and i3 in the marmoset monkey (callithrix jacchus) following dietary supplementation with tuna fish oil.	recent studies have shown that ingestion of eicosapentaenoic acid (epa) in man results in the formation of 'trienoic' prostanoids which amy partly explain the potent antithrombotic/antiatherogenic properties of long-chain polyunsaturated n-3 fatty acids (pufas). however, endogenous formation of cyclooxygenase metabolites of epa has not been demonstrated in an animal model, and in vitro studies indicate a clear species difference in the conversion of epa to pgi3. thus, in the present study, the i ...	1989	2659082
experimental brugia pahangi and b. malayi infections of callitrichid primates.	the callitrichid primates, callithrix jacchus jacchus (the marmoset) and saguinus labiatus (the tamarin) were inoculated with infective larvae of brugia malayi and b. pahangi. microfilaraemia at low levels developed in 3 out of 4 c.j. jacchus infected with b. malayi and living or dead adult worms found in all 4. only one of 4 c.j. jacchus became microfilaraemic (mf + ve) when given b. pahangi and adults were found in two. of 4 s. labiatus given b. pahangi one became very lightly mf + ve and adul ...	1989	2500478
termination of pregnancy in common marmosets (callithrix jacchus) following administration of antiserum to chicken riboflavin carrier protein.	the presence of protein(s) which is immunologically and functionally similar to the well characterised avian riboflavin carrier protein has been demonstrated in female common marmosets during pregnancy. the protein(s) that interacts with [14c]riboflavin has an immunological homology to chicken riboflavin carrier protein. the termination of pregnancy in four out of six marmosets following administration of antiserum to chicken riboflavin carrier protein supports the hypothesis that vitamin carrie ...	1989	2503615
comparison of the metabolism and disposition of [3-14c]coumarin in the rat and marmoset (callithrix jacchus).	male sprague-dawley rats and marmosets were given a single oral 25 mg/kg dose of [3-14c]coumarin and the excretion of radioactivity in the expired air, urine and faeces monitored up to 96 h. excretion profiles were similar in both species with the bulk of the dose being excreted in the urine and faeces within 24 h. chromatographic analysis of 0-48 h urine samples revealed similar metabolic profiles with only small amounts of unchanged coumarin and very little 7-hydroxycoumarin. coumarin 7-hydrox ...	1989	2493171
inoculation of new world primates with the human immunodeficiency virus.	the susceptibility of common marmosets and cotton-top tamarins to infection by hiv-2 in vivo was tested. one year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for hiv-2 antibodies and hiv-specific nucleotide sequences were demonstrated in short-term cultures of pbl from two cotton-top tamarins. the animals remain in good health.	1989	2503618
the callimico goeldii (primates, platyrrhini) genome: karyology and middle repetitive (line-1) dna sequences.	callimico goeldii (goeldi's marmoset) is a neotropical primate with 2n = 47,x1x2y in the male, and 2n = 48,x1x1x2x2 in the female, due to a y-autosome translocation. karyological comparisons of callimico, callithrix jacchus and cebus apella suggest that callimico is a member of the callitrichidae. isozyme data and restriction mapping of line-1 repetitive elements in these species and in a variety of other neotropical primates confirm these findings and supply strong evidence for including callim ...	1989	2560695
the topology of the thalamo-cortical projections in the marmoset monkey (callithrix jacchus).	this paper addresses the question of a general topological principle of thalamo-cortical projections. in the lissencephalic primate brain of the common marmoset (callithrix jacchus), large injections of horseradish peroxidase were made in various parts of the neocortex. these injections were placed in different animals and hemispheres along various caudo-rostral and medio-lateral gradients. labelled cells in the thalamus were plotted and the labelling-zones resulting from several injections alon ...	1990	2394218
suppression of bioactive luteinizing hormone and testosterone by a progesterone antagonist zk 98.734 in adult male common marmosets, callithrix jacchus.	the effects of a progesterone antagonist zk 98.734 on release of bioactive luteinizing hormone (lh) and testosterone were studied in adult male common marmosets by using the following experimental protocols: (1) the blocking of the nocturnal rise in testosterone levels by zk 98.734, (2) the pharmacodynamic effects of zk 98.734 on testosterone and lh levels, (3) the reversal of zk 98.734-induced decrease in testosterone by treatment with human chorionic gonadotropin (hcg), and (4) the blocking of ...	1990	2116922
inhibin secretion during the ovulatory cycle and pregnancy in the common marmoset monkey.	changes in plasma concentrations of immunoreactive inhibin in the reproductively cyclic, pregnant and ovariectomized female marmoset monkey (callithrix jacchus) were measured with a heterologous radioimmunoassay. the pattern of inhibin secretion in five marmosets studied individually during four consecutive cycles was shown to resemble that of progesterone. in these animals, data were pooled according to stage of cycle on the basis of plasma progesterone concentrations. mean values for inhibin w ...	1990	2212937
isolation and characterization of several plasma apolipoproteins of common marmoset monkey.	to explore the potential of the common marmoset monkey (callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) a-i, a-ii, c-iii, and a-iv. the first 54 residues of marmoset apo a-i showed 87% sequence identity with the corresp ...	1990	2114867
isolation and characterization of plasma lipoproteins of common marmoset monkey. comparison of effects of control and atherogenic diets.	this study examines the potential of the common marmoset monkey (callithrix jacchus) to serve as a model for human lipoprotein metabolism and atherosclerosis. the lipoproteins of animals fed a low-fat, low-cholesterol diet and a high-fat (12% wt/wt lard), high-cholesterol (0.34% wt/wt) diet were characterized by the combination of sequential ultracentrifugation and pevikon block electrophoresis. based on chemical and physical properties, equivalents of human very low density lipoproteins (vldl), ...	1990	2114868
distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset.	the serotoninergic innervation of the marmoset (new world monkey, callithrix jacchus) cerebral cortex has been analyzed by using immunocytochemistry. the use of a sensitive monoclonal antibody against serotonin allowed the visualization of the fine morphology of individual axons. two types of terminal axons were demonstrated: one has sparse, small, ovoid varicosities (dia. less than 1 micron), and the other has large, spheroidal varicosities (up to 5 microns in dia.), which are more densely clus ...	1990	2115053
ofloxacin in juvenile non-human primates and rats. arthropathia and drug plasma concentrations.	arthropathia in juvenile animals is the most important toxic effect induced by quinolones. we conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (callithrix jacchus, marmosets) and rats. in the marmoset, electron microscopy and the application of immuno-morphological methods proved to be suitable for the detection of specific alterations in cartilage (e.g. loss of proteoglycans and altered chondrocytes). subsequently performed electron microscopic examinatio ...	1990	2115323
genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar mhc class i gene products.	the cotton-top tamarin (saguinus oedipus) is a naturally occurring "a" + "b"----"a" bone marrow-chimeric species. these primates usually are born as dizygotic twins and, due to placental vascular anastomoses, develop sharing each others' bone marrow elements. strikingly, almost 50% of the pbl of a member of a twin pair are derived from the hematopoietic stem cells of its cotwin. to clarify the mechanisms underlying the maintenance of tolerance in these stable chimeras, mhc gene products have bee ...	1990	2110210
monoclonal antibodies from epstein-barr virus-transformed lymphocytes of common marmosets (callithrix jacchus) immune to malaria.	the b lymphocytes of the common marmoset callithrix jacchus can be immortalized by infection with epstein-barr virus (ebv) in vitro (desgranges et al., 1976). c. jacchus is susceptible to infection with the blood stages of several species of malaria parasite including the line designated mvf1 (mitchell et al., 1988) from which it recovers and shows immunity to reinfection. by exploiting these two phenomena, ebv-transformed, marmoset lymphoblastoid cell lines secreting antibodies to malaria paras ...	1990	2155967
1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) is less neurotoxic than mptp in the common marmoset.	four adult marmosets were treated with increasing doses of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) in the range 0.23-4.3 mg/kg i.p. to give a cumulative dose of 11.0-11.6 mg/kg over a 6-10 day period. after 4 days of treatment, and as the dosage was gradually increased, the animals exhibited mild motor deficits. these abnormalities slowly declined over the following 1-6 week period. in contrast, similar treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6 ...	1990	2117541
n-3 and n-6 phosphoglyceride fatty acids in relation to in vitro erythrocyte haemolysis induced by hydrogen peroxide in captive common marmosets (callithrix jacchus).	1. hydrogen peroxide-induced haemolysis (hpih) was studied in the red blood cells of the common marmoset monkey (callithrix jacchus) in relation to the composition of the membrane fatty acids. hpih (%) was surprisingly high (mean 41% +/- 34; median 33.4%) and significantly different (p less than 0.001) from the corresponding value in healthy human subjects (mean 0.98% +/- 0.6; median 1.3%). 2. it was negatively correlated with 18:2n-6 (r = -0.76, p less than 0.001), 18:2n-6/20:4n-6 (r = -0.70, p ...	1990	2123763
persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) in hepatic and adipose tissue of marmoset monkeys.	a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to marmoset monkeys (callithrix jacchus). tissue concentrations in hepatic and adipose tissue were measured at different times after treatment (1-28 weeks). one week after application high concentrations could be detected for the 2,3,7,8-substituted congeners only. the percent of the administered dose in whole liver differed for the various 2,3,7,8-substituted congeners, ran ...	1990	2125825
transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) via placenta and through milk in a marmoset monkey.	a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to a pregnant marmoset monkey (callithrix jacchus) 11 weeks prior to delivery. transfer of pcdds and pcdfs via placenta and mother's milk was investigated by measurement of concentrations in a newborn 1 day after birth and in an infant of the same litter after a lactation period of 33 days. furthermore, comparative measurements were performed in different tissues of the moth ...	1990	2128593
extension of reproductive suppression by pheromonal cues in subordinate female marmoset monkeys, callithrix jacchus.	pheromonal signals from the dominant female marmoset monkey were implicated in maintaining the suppression of lh secretion and ovulation in socially subordinate females. when subordinate, and reproductively suppressed, female marmoset monkeys were removed from their group without scent contact with their dominant females, subordinate females in control group 1 (n = 8) and control group 2 (n = 5), ovulated 10.8 +/- 1.4 days and 10.4 +/- 0.8 days respectively (mean +/- s.e.m.) after separation. su ...	1990	2250240
studies on the ascorbic acid metabolism of callitrichid monkeys by 14c isotope excretion technique.	recently it has been found that the two monkey species callithrix jacchus and saguinus fuscicollis, both belonging to the same new world monkey family callitrichidae and held in the same colony under identical conditions, had extremely different serum ascorbate levels. to examine the ascorbic acid metabolism the 14c-excretion of orally given 1-14c-ascorbic acid was studied under conditions of marginal and abundant vitamin c supply and under intentional stress. there were large differences in the ...	1990	2251861
[radiotelemetric studies of the body temperature of white-tufted monkeys (callithrix jacchus)].	a newly developed telemetry system was used to study deep body temperature (bt) of two adult male common marmosets (callithrix jacchus). the bt-curves of both monkeys showed a similar clear circadian rhythm with a range up to 3.5 degrees c. at environmental temperature of 28 degrees c (et) the bt of the monkeys varied in the daytime dependent on their spontaneous activity, with little individual differences between 37.5 degrees c and 39.3 degrees c; at night the bt of the remarkably deeply-sleep ...	1990	2251862
transmammary transmission of mesocercariae of alaria marcianae (trematoda) in experimentally infected primates.	a lactating primate, callithrix jacchus, was infected experimentally with 600 mesocercariae of alaria marcianae 10 days after parturition to determine if she would transmit the mesocercariae to her offspring. her twin infants were examined 4 wk postinoculation and 16 mesocercariae were found in their tissues. the female was mated again and gave birth to a litter of triplets. she was not given additional mesocercariae. one infant died within hours of birth without suckling and was found negative ...	1990	2254822
morphology of neuropeptide y-immunoreactive neurons in the cat olfactory bulb and olfactory peduncle: postnatal development and species comparison.	the distribution and morphology of neuropeptide y-immunoreactive (npy-ir) neurons in the olfactory bulb and the olfactory peduncle was studied in the adult cat and rat, and the common marmoset callithrix jacchus. significant species differences were not observed. in all three species, the population of npy-ir neurons is localized in the white matter extending from the main olfactory bulb to the border of the striatum. the neurons are characterized by a conspicuously looping axonal ramification p ...	1990	2298945
an ultrastructural study of early chorionic villus formation in the marmoset monkey (callithrix jacchus).	the ultrastructural morphology of developing chorionic villi in the marmoset monkey (callithrix jacchus) placenta was studied in pregnant monkeys at known time intervals after ovulation. in samples obtained at 45 days after ovulation the mesoderm, which consists of primitive foetal blood vessels, is seen to extend down into cytotrophoblast columns. syncytiotrophoblast completely surrounds maternal blood vessels and both basal laminae and endothelial cells of maternal origin show signs of disorga ...	1990	2305971
polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. effects on peripheral lymphocyte subpopulations of a non-human primate (callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd).	monoclonal antibodies were used to analyse the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on peripheral lymphocytes from marmosets (callithrix jacchus) following injections of single low doses of tcdd. a reduction of the percentage and the total number of lymphocytes among the white blood cells was seen 3 weeks after a single administration of 300 ng tcdd/kg body wt, but not following 167 ng tcdd/kg or less. after treatment of marmosets with the single subcutaneous dose of 10 ng tcdd/ ...	1990	2403285
evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (callithrix jacchus).	a subacute toxicity study of indomethacin administered by oral route, was carried out in the marmoset (callithrix jacchus). groups of three males and three females received indomethacin directly into the stomach by means of a catheter for a period of 4 weeks at the dose levels of 0, 2, 6, and 12 mg/kg body wt/day and then were euthanized for pathological evaluation. all marmosets given 12 mg/kg/day and one marmoset given 6 mg/kg/day died during the dosing period (within 20 days). at 12 mg/kg/day ...	1990	2086319
lack of change in striatal darpp-32 levels following nigrostriatal dopaminergic lesions in animals and in parkinsonian syndromes in man.	the present study was performed to determine the effect of a nearly complete nigrostriatal dopaminergic denervation on darpp-32 levels in the striatum from animals and parkinsonian patients. darpp-32 levels were estimated by in vitro phosphorylation in the presence of camp, or after inactivation of endogenous kinases and phosphatases, in the presence of the catalytic subunit of camp-dependent protein kinase. intranigral 6-hydroxydopamine (6-ohda) infusion in rats, or peripheral administration of ...	1990	2105823
synthesis of human renin inhibitory peptides, angiotensinogen transition-state analogs containing a retro-inverso amide bond.	the experimental details for the synthesis of human renin inhibitors are described. in order to avoid metabolic degradation of the phe-his (p3-p2) amide bond in transition-state analogs, structurally modified acyl residues (p4-p3) were incorporated into the inhibitors. compound 1a, which contained 2-(1-naphthylmethyl)-3-(n-phenethylcarbamoyl)propionyl residue (p4-p3) with a retro-inverso amide bond, l-histidine, and norstatine isoamylamide residue (p1-p1) as a transition-state mimic, had potent ...	1990	2085885
immunoregulation in the common marmoset, calithrix jaccus: functional properties of t and b lymphocytes and their response to human interleukins 2 and 4.	non-human primates have been used to study immune function to a much lesser extent than readily available strains of inbred rodents. nevertheless, in situations where it might be desirable, but impossible, to study human immune responses in vivo, lower primates could provide an acceptable alternative. in order to extent the knowledge of t- and b-lymphocyte function in lower primates, the common marmoset callithrix jaccus was used as an experimental model. the functional similarities between this ...	1990	2110549
plasma vitamins a and e and hydrogen peroxide-induced in vitro erythrocyte haemolysis in common marmosets (callithrix jacchus).	plasma total lipid, cholesterol, all-trans retinol (vitamin a) and alpha-tocopherol (vitamin e) concentrations, and the susceptibility of erythrocytes to hydrogen peroxide-induced haemolysis in vitro were investigated in healthy laboratory-bred common marmosets (callithrix jacchus). the concentrations of alpha-tocopherol and total cholesterol were similar to those of control human subjects. the mean lipid concentration was higher (p less than 0.025) and the retinol concentration lower (p less th ...	1990	2111954
immunofluorescence-microscopic localization of collagen type iv and vi, laminin and nidogen in the livers of callithrix jacchus during pre- and postnatal development.	the distribution of collagen type iv and vi, laminin and nidogen was investigated by immunofluorescence microscopy in the livers of marmosets (callithrix jacchus) at various stages of development, i.e. on days 93, 111, 116 and 134 of gestation, 1 day postpartum and at the mature stage. large amounts of collagen type iv could in all cases be demonstrated in the sinus wall and in all basal laminae outside the lobule. after the application of antibodies against collagen type vi the sinus wall showe ...	1990	2117839
plasma melatonin exhibits a diurnal secretion in the common marmoset (callithrix jacchus): relationship to the rest-activity cycle.	the secretion of plasma melatonin exhibits a diurnal variation in the common marmoset (callithrix jacchus jacchus) (n = 12) with mean values of 125.8 fmol/ml during darkness and below assay sensitivity (mean 70.5 fmol/ml) during the light period. both melatonin secretion and the rest activity cycle appeared to be phase advanced with relation to the light dark cycle which is consistent with an endogenous circadian period (tau) of less than 24 h in this species.	1990	2116518
medial hypothalamic lesions and sexual receptivity in the female common marmoset (callithrix jacchus).	medial hypothalamic lesions cause major deficits in sexual receptivity in a variety of mammalian species. effects of such lesions upon sexual receptivity in female primates have not been investigated. two experiments are described in which thermal lesions were made in the hypothalamus in 11 ovariectomized or ovariectomized/adrenalectomized, oestradiol-treated common marmosets. proceptivity (sexual initiating behaviour) was reduced or abolished by lesions in the dorsomedial or ventromedial hypoth ...	1990	2108915
screening procedure for assessment of ototoxicity in the common marmoset.	detection of drug-induced ototoxicity in safety evaluation studies of novel chemical entities is rarely attempted. where such examinations are included, they usually rely on reflex testing. the brainstem auditory evoked response can be measured with the use of externally positioned electrodes, and it monitors electrophysiologic responses to sound from the cochlear nerve and associated structures of the 8th cranial nerve. these responses have been reproducibly measured in sedated marmosets and th ...	1990	2214803
a lobster claw abnormality in the common marmoset (callithrix jacchus).	a congenital abnormality of the digits, similar to the 'lobster claw' deformity of humans, was observed in 8 common marmosets. the condition varied in severity and in effect on the animals; it appeared to be due to a single autosomal recessive trait.	1990	2366513
adenocarcinoma of the small intestine in a common marmoset (callithrix jacchus).		1990	2157108
[the distribution of different collagen types and laminin in the gingiva of the common marmoset (callithrix jacchus)].	the distribution of the collagen types i, iii, iv, v, vi and of the glycoprotein laminin have been examined in the healthy gingiva of the marmoset with the indirect immunofluorescence method. it has been shown that collagen type i formed thick fibrils in a wave-like pattern, while collagen type iii formed thinner fibrils, especially under the epithelial basal membrane. collagen type iv and laminin showed a strong fluorescence in the basal membrane (epithelium, vessels, nerves). collagen type v h ...	1990	2237364
cell proliferation in the subependymal layer of the postnatal marmoset, callithrix jacchus.	cells of the subependymal layer (sel) have been shown to be capable of continued postnatal cell division throughout life in rodents. to determine if the primate brain behaves similarly, proliferative activity in the sel of the marmoset has been investigated by tritiated thymidine autoradiography and bromodeoxyuridine immunocytochemistry. both methods revealed the presence of dna-synthesizing cells at all postnatal ages studied. the labelling index (li), low at birth, reached a peak of almost 4% ...	1990	2073725
central oxytocin stimulates luteinizing hormone release in the marmoset, a primate which fails to show lactationally-lnduced infertility.	in several species, including humans, suckling is known to suppress pulsatile gonadotrophin secretion and substantially reduce fertility (1). during suckling high titres of oxytocin are present in both plasma (2, 3) and cerebrospinal fluid (csf) (4) and there is some evidence that oxytocin is inhibitory to gonadotrophin secretion by an action on t h e central nervous system, (5, 6). the common marmoset, however, has a different physiological response and fails to show lactational infertility; ov ...	1990	19215367
the facial artery of the common marmoset (callithrix jacchus).	the facial artery and its ramifications in 7 adult common marmosets (callithrix jacchus) were studied by the plastic injection method. the findings obtained are discussed in comparison with those for other primates. in the submandibular region, the facial artery arose from the external carotid artery at the height of the atlas via the linguofacial trunk on 10 of the total of 14 sides examined and independently on the other 4 sides. this common trunk always gave rise to the superior thyroid arter ...	1990	2216318
motor activity following the administration of selective d-1 and d-2 dopaminergic drugs to normal common marmosets.	in normal common marmosets administration of the d-1/d-2 agonist apomorphine or the selective d-2 agonist quinpirole caused a dose-dependent increase in motor activity and induced stereotyped behaviour. both the selective d-2 antagonist raclopride and the selective d-1 antagonist sch 23390 inhibited normal locomotor activity and induced catalepsy. quinpirole- and apomorphine-induced motor activity were potently inhibited by pretreatment with raclopride. the effects of quinpirole, but not apomorp ...	1991	1686813
the effect of dietary change on in vitro erythrocyte haemolysis, skin lesions and alopecia in common marmosets (callithrix jacchus).	1. the effect of dietary change on common marmosets (callithrix jacchus) exhibiting high in vitro erythrocyte haemolysis, skin lesions and alopecia was investigated. 2. the experimental diet was low in lipid, high in vitamin e and was devoid of n-3 long chain polyunsaturated fatty acids. 3. there were significant increases in the concentrations of plasma alpha-tocopherol (vitamin e) (p less than 0.05), all-trans retinol (vitamin a) (p less than 0.001) and total lipid (p less than 0.025), and a r ...	1991	1685382
development of a monoclonal antibody, anti-6c2, which is involved in the interaction of cd4 t helper cells and activated b cells.	we have developed a mab anti-6c2, by immunizing mice with t cell line derived from the callithrix jacchus (common marmoset). anti-6c2 is reactive with approximately 50% of unfractionated t cells, 50% of cd4+ cells, and 40% of cd8+ cells. regarding cd4+ cells, anti-6c2-reactive cells substantially overlap with the cd29+cd45ro+ th cell population. moreover, anti-6c2 can divide these t cells into 6c2+ and 6c2- subpopulations. the cd4+cd45ro+6c2+ cells maximally respond to soluble ag such as tetanus ...	1991	1706389
penile spines affect copulatory behaviour in a primate (callithrix jacchus).	androgen-dependent, keratinized "spines" occur on the glans penis in many rodents, primates and other mammals. since penile spines overlie dermal tactile receptors, they may play a role in copulatory behaviour. an experiment was conducted to test this hypothesis. sixteen sexually experienced adult male marmosets were paired with ovariectomized females before, and after, removal of penile spines (using thioglycollate cream applied to the glans under anaesthesia) or a sham operation. spine removal ...	1991	2062934
the local domain for divergence of subcortical afferents to the striate and extrastriate visual cortex in the common marmoset (callithrix jacchus): a multiple labelling study.	in the common marmoset (callithrix jacchus), the cortical projection from the pulvinar and other diencephalic structures into the striate and prestriate cortex was investigated with various fluorescent retrograde tracers. single cortical injections as well as multiple injections at distances of 1-2 mm with one tracer into an extended but coherent cortical region were applied. fields with multiple injections were placed so that they touched each other (minimal distances 2 to 3 mm). retrogradely l ...	1991	1712315
ultrastructural and histochemical characterization of marmoset (callithrix jacchus) leydig cells during postnatal development.	leydig cell development was investigated in the marmoset (callithrix jacchus) testis from 24 h post partum (pp) up to sexual maturity, using ultrastructural and histochemical methods. electron microscopically three different leydig cell (lc) types could be distinguished: neonatal, immature and adult lcs. neonatal lcs exhibited a round nucleus, large tubular mitochondria, abundant smooth endoplasmic reticulum (ser), and few small fat vesicles. the typical immature lcs showed a lobulated nucleus, ...	1991	1903613
urinary protein pattern reflects social rank in male common marmosets (callithrix jacchus).		1991	1794772
extensive loss of brain dopamine and serotonin induced by chronic administration of mptp in the marmoset.	common marmosets were given a subcutaneous injection of mptp (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. the parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine and, to a lesser extent, of its metabolites in the striatum and in some extrastriatal regions. there was also a profound loss of serotonin in the striatum and in all of the extrastri ...	1991	1815820
neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with mptp.	aged common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; 0.5-2.0 mg/kg/week i.p.) for 16 or 24 weeks, observed for a total of 30 weeks and then killed for measurement of biochemical parameters in basal ganglia. the mptp treatment induced a marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in the caudate nucleus and putamen. in contrast, the concentrations of five neuropeptides: [met5]-enkephalin, [leu5]-enkephalin, cholec ...	1991	1716907
immunohistochemical distribution of the collagen types iv, v, vi and glycoprotein laminin in the healthy rat, marmoset (callithrix jacchus) and human gingivae.	the purpose of this study was to demonstrate the localization of collagen types iv, v and vi as well as the glycoprotein laminin in biopsies of healthy rat, marmoset (callithrix jacchus) and human gingivae. the slices, after the use of indirect immunofluorescence (incubation with antibodies against these extracellular matrix components), showed the same distribution with the anti-type iv and laminin antibodies on the basement membranes of the epithelium, blood vessels and nerves. collagen type v ...	1991	1906570
identification and characterization of the herpesvirus saimiri oncoprotein stp-c488.	the protein encoded by herpesvirus saimiri transforming gene stp-c488 was identified and characterized. antibodies were produced in rabbits by immunization with keyhole limpet hemocyanin-conjugated synthetic peptides specific for the predicted sequence of stp-c488. stp-c488-encoded protein was detected in recombinant escherichia coli, transformed rat-1 cells, transfected cos-1 cells, and in common marmoset t lymphocytes immortalized by herpesvirus saimiri strain 488. stp-c488 protein was sensiti ...	1991	1658384
treatment with antioxidants does not prevent loss of dopamine in the striatum of mptp-treated common marmosets: preliminary observations.	administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets causes a profound loss of dopamine and serotonin in the striatum. additional daily systemic treatment of monkeys with the antioxidants ascorbic acid (100 mg/kg) and alpha-tocopherol (2,350 mg/kg) prior to, during and following administration of mptp does not prevent the loss of dopamine and serotonin in the striatum, suggesting that these antioxidants are unable to protect dopaminergic neurones against neur ...	1991	1905937
[the significance of pcdd's/pcdf's (dioxins) in pediatrics].	no epidemiological data are available up to now which reveal adverse effects induced by dioxins during an exposure through breast milk. furthermore, very few data on the concentration of pcdds/pcdfs in the newborn and during the first year of life have been published. of all pcdds/pcdfs, the substance with the highest toxicity is 2,3,7,8-tetrachlorodibenzo-p-dioxin. however, in the environment this congener is often only a minor component. a sensitive biological effect triggered by tcdd is the e ...	1991	1961212
[3h]harman binding experiments. ii: regional and subcellular distribution of specific [3h]harman binding and monoamine oxidase subtypes a and b activity in marmoset and rat.	[3h]harman (1-[3h]methyl-beta-carboline) was used in a novel radioligand binding assay to label selectively and with high affinity monoamine oxidase (mao) type a. the concentration of the enzyme was determined in six cns regions of the primate species marmoset (callithrix jacchus) and of the rat: hypothalamus, hippocampus, cerebellum, cerebral cortex, striatum, and spinal cord. the specific [3h]harman binding in the cns of the marmoset reveals the same pharmacological profile and other character ...	1991	1988553
[yersinia pseudotuberculosis in new world monkeys].	it is reported on four cases of pseudotuberculosis in 2 saimiri sciureus, 1 callithrix jacchus/penicillata hybrid and 1 s. oedipus. the animals came from two different groups, one being infected with y. pseudotuberculosis serotype i, the other with y. pseudotuberculosis serotype ii. all cases showed intestinal infection of thermophile campylobacter. remarkable were severe haemorrhagic components and the distinct rhs-proliferation, especially in the mesenteric lymphatic nodes.	1991	2015031
synergism of the ampa-antagonist nbqx and the nmda-antagonist cpp with l-dopa in models of parkinson's disease.	degeneration of dopaminergic nigrostriatal neurons in parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. in theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. the selective ampa-antagonist nbqx and the competitive nmda-antagonist cpp are not effective in animal models of parkinson's disease when given a ...	1991	1835581
morphological and histochemical effects of 2,3,7,8-tetrachlorodibenzo-p dioxin (tcdd) on marmoset (callithrix jacchus) testes.	the testes of marmosets (callithrix jacchus), which had been treated with a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) (0.3 microgram to 10 micrograms/l kg body weight (bw)) were studied after 7 days using morphological and histochemical techniques. light microscopic and electron microscopic examination revealed decreased intercellular contact in the germinal epithelium, as indicated first by enlarged intercellular spaces between the sertoli's cells and between the sertoli's cells ...	1991	1872647
an enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny.	1. a soluble human brain aminopeptidase which hydrolyses the tyr-gly bond of met-enkephalin and leu-enkephalin was identified in the brains of the following vertebrates: mammals (callithrix jacchus and rattus norvegicus), bird (gallus domesticus), reptile (tupinambis teguixin), amphibia (bufo paracnemis), fish (sarotherdon niloticus) and elasmobranchy (galeocerdo cuvieri). 2. the properties of this enzyme are: molecular weight near 100,000 da, isoelectric point near 4.9, optimum ph near 7.5, act ...	1991	1685408
differential effects of dietary fish oil on myocardial prostaglandin i2 and thromboxane a2 production.	marmoset monkeys (callithrix jacchus) were maintained for 24 mo on a standard primate diet [reference (ref) diet] or this diet supplemented (8% wt/wt) with either sheep fat (sf), sunflower seed oil (sso), or tuna fish oil (tfo). the polyunsaturated fatty acids (pufa) of myocardial phospholipids demonstrated significant alterations as a result of the dietary (n-3) or (n-6) lipid supplementation. the reduction (p less than 0.05) in prostaglandin (pg) i2 in pufa diet-fed groups (sso, 113.8 +/- 7.8; ...	1991	1899979
topographical and topological organization of the thalamocortical projection to the striate and prestriate cortex in the marmoset (callithrix jacchus).	in eleven hemispheres of nine marmoset monkeys (callithrix jacchus), we have investigated the thalamo-cortical organization of the projections from the pulvinar to the striate and prestriate cortex. in each experiment, single or multiple injections of various retrograde fluorescent tracers were injected into adjacent regions or areas. in two experiments, horseradish peroxidase (hrp) was injected into the lateral geniculate nucleus (lgn) and the lateral pulvinar, respectively. the results show th ...	1991	1712314
distribution and morphology of substance p-immunoreactive structures in the olfactory bulb and olfactory peduncle of the common marmoset (callithrix jacchus), a primate species.	the present study describes the morphology and distribution of substance p-immunoreactive (sp-ir) elements in the olfactory bulb (ob) and olfactory peduncle (op) of the common marmoset (callithrix jacchus), a primate species. sp-ir neurons are very abundant in the ob and belong to two types. external tufted cells are present in the glomerular layer (gl), whereas granule cells are found in the deeper layers, especially in the granule cell layer (grl), but also scattered in the op. sp-ir fibers, p ...	1991	1724304
an evaluation of two animal models for dietary influences on reproductive toxicology.	chronic protein deficiency (8 weeks) was examined in marmosets (callithrix jacchus) and sub-acute (1 week) methionine- and choline-deprivation was investigated in f344 rats. the marmosets were considered to have become protein-deficient but there was no alteration in sperm morphology, either at the end of the diet or 5 weeks later. weight loss was also observed in rats on the methionine- and choline-free diet and they had significantly decreased sperm counts 4 weeks after the end of treatment. h ...	1991	1768785
ontogeny of monooxygenase activities in the marmoset monkey (callithrix jacchus).	the pre- and postnatal development of monooxygenases in the liver and adrenal gland of marmoset monkeys (callithrix jacchus) was investigated. cytochrome p450 was detected in the fetal adrenal gland, but aldrin epoxidase, ethoxycoumarin o-deethylase, and ethoxyresorufin o-deethylase activities were below detection limits. although fetal hepatic cytochrome p450 was not detected, low activities of aldrin epoxidase and ethoxycoumarin o-deethylase, but no ethoxyresorufin o-deethylase, could be detec ...	1991	1787526
lipoprotein(a) and apolipoprotein(a) in a new world monkey, the common marmoset (callithrix jacchus). association of variable plasma lipoprotein(a) levels with a single apolipoprotein(a) isoform.	in an earlier report (chapman et al, biochemistry 1979;18:5096-5108), we suggested that the common marmoset may represent an important model for the study of human plasma lipoprotein metabolism. we now extend the interest of this monkey model to the study of lipoprotein(a) (lp[a]) and apolipoprotein(a) (apo[a]). density gradient ultracentrifugal fractionation of marmoset plasma revealed a bimodal distribution of lp(a), with one peak of concentration occurring in association with very low density ...	1991	1829630
olfactory bulb granule cell aggregates: morphological evidence for interperikaryal electrotonic coupling via gap junctions.	anaxonic interneurons of the granule cell type in the mammalian main olfactory bulb (mob) are characterized by prominent membrane specializations, which include reciprocal, interdendritic chemical and electrical synapses; however, the latter are thought to be restricted to the external plexiform layer (epl) and connect granule-mitral- and granule-tufted-cell dendrites (landis et al., 1974). the present study focuses on interperikaryal membrane specializations between tangentially oriented aggreg ...	1991	1904478
polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 2. in vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on lymphocytes of venous blood from man and a non-human primate (callithrix jacchus).	the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on poke weed mitogen-stimulated proliferation and differentiation of peripheral lymphocytes was studied in vitro with cells from a non-human primate (marmoset monkey, callithrix jacchus) and from man. monoclonal antibodies and flow cytometry (facscan) were used for analysis. the extent of the overall mitogen-stimulated proliferation of isolated lymphocytes in vitro from marmoset blood was only slightly reduced in the presence of tcdd compa ...	1991	1905127
[wound healing of the cornea of new world monkeys after surface keratectomy: er:yag-excimer laser].	corneal wound healing was studied after photoablation with an excimer laser (193 nm, 43 pulses at 180 mj/cm2 [symbol: see text] 11 microns ablation depth, optical zone 2.0 mm) and with an erbium-yag laser (2.94 microns, 5 pulses at 2.5 j/cm2 [symbol: see text] 50 microns ablation depth, optical zone 1.6 mm). the corneas of marmosets (callithrix jacchus) were prepared 5 and 10 days and 4 and 25 weeks after photoablation. the sections were investigated by conventional light microscopy or exposed t ...	1991	1786926
neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in the common marmoset: implications for parkinson's disease?	protracted long-term treatment of common marmosets with 15 doses (0.5-4.5 mg/kg, i.p.) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; total dose 25 mg/kg, given over 29 days) caused transitory changes in motor behaviour reminiscent of human parkinson's disease. 16 days from the start of mptp administration, all animals showed motor impairment, consisting of profound akinesia and a rigid posture, but in no case resting tremor. biogenic amines were measured in nigrostriatal regions one mon ...	1991	1712088
immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). ii. distribution of collagen types iv, v and vi.	the immunohistochemical distribution of collagen types iv, v and vi has been demonstrated in healthy periodontal tissues of rats and marmosets following decalcification of the maxillae and mandibulae in 0.2 n hcl. an intense fluorescence with anti-collagen type iv antibodies was demonstrated in the basement membranes of the epithelium and of the blood vessels and nerves. in the alveolar bone stroma and in the periodontal ligament (pl) collagen type iv was present only in the basal membranes of t ...	1991	1714953
isolation of an arenavirus from a marmoset with callitrichid hepatitis and its serologic association with disease.	callitrichid hepatitis (ch) is an acute, often fatal viral infection of new world primates from the family callitrichidae. the etiologic agent of ch is unknown. we report here the isolation of an arenavirus from a common marmoset (callithrix jacchus) with ch by using in vitro cultures of marmoset hepatocytes and vero-e6 cells. enveloped virions 67 to 133 nm in diameter with ribosomelike internal structures were seen in infected cultures. immunofluorescence and western immunoblot analysis using c ...	1991	1712856
co2 breath tests using 14c-caffeine, 14c-methacetin and 14c-phenacetin for assessing postnatal development of monooxygenase activities in rats and marmosets.	the time course in which the activities of cytochrome p450-dependent drug-metabolizing enzymes develop during the perinatal period differs for various types of monooxygenases as well as for various animal species. using [3-methyl14c]-, [7-methyl14c]-caffeine, [14ch3]-methacetin and [14c2h5]-phenacetin as substrates in breath tests, the developmental changes in the rates of 14co2 formation, due to changes in the activity of monooxygenases, were studied in rats and marmoset monkeys (callithrix jac ...	1991	1914790
de novo biosynthesis and localization of inhibin in marmoset (callithrix jacchus) and rat epididymis.	using specific polyclonal antibodies generated against a 13 kd human testicular inhibin, immunocytochemical localization was carried out in epididymis of intact and castrated marmoset monkey and rat epididymis. inhibin was found to be present in the cytoplasm of epithelial cells of caput, corpus and cauda epididymis. the intensity of staining and pattern of distribution did not change following castration. further, the in vitro biosynthesis of inhibin studied by incorporating 3h-leucine and prec ...	1991	1769713
"environmental stress" and reproductive success in the common marmoset (callithrix jacchus jacchus).	the present report documents the breeding success of a new colony of common marmosets (callithrix jacchus jacchus) and demonstrates a correlation between environmental stress and reproductive success. environmental conditions ranged chronologically over 40 months, through four periods: i) the initial period, when the colony was formed; ii) a phase of relative environmental stability; iii) a stage of "environmental stress" (when the colony was disrupted by nearby construction); and iv) a return t ...	1991	31948181
infant carrying in a polygynous group of common marmosets (callithrix jacchus).	in a captive group of common marmosets (callithrix jacchus), consisting of six group members and the three infants of the two breeding females, we analyzed participation of all group members in infant carrying, and suckling by the two breeding females. during the first two weeks of the infants' lives, the two breeding females carried their own infant(s) almost exclusively due primarily to the mutual avoidance by the two females. at the beginning of the third week of the infants' lives nearly all ...	1991	31948177
reversible, long-term inhibition of ovulation with a gonadotropin-releasing hormone antagonist in the marmoset monkey (callithrix jacchus).	the effects of weekly injections of a gonadotropin-releasing hormone (gnrh) antagonist (gnrha) ([n-acetyl-dβnal1-d-pcl-phe2-d-phe3-d-arg6-phe7-arg8d-ala10] nh2 gnrh) on pituitary and ovarian function were examined in the marmoset monkey, callithrix jacchus. in experiment 1, five cyclic females were given weekly injections of vehicle (50% propylene glycol in saline) for 6 weeks followed by gnrha for 20 weeks, animals receiving either 200 μg gnrha/injection (n = 2) or 67 μg gnrha/injection (n = 3) ...	1992	31948156
cellular localization of tyrosine hydroxylase mrna and cholecystokinin mrna-containing cells in the ventral mesencephalon of the common marmoset: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	in situ hybridization histochemistry was used to localize tyrosine hydroxylase (th) mrna and cholecystokinin (cck) mrna-expressing cells in the ventral mesencephalon of the common marmoset (callithrix jacchus) and to examine the effects of the dopaminergic (da) neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on these two populations of neurons in the pars compacta of the substantia nigra (snc) and ventral tegmental area (vta). x-ray film and liquid emulsion autoradiography of bra ...	1992	1347634
behavioural analysis of unilateral monoamine depletion in the marmoset.	unilateral stereotaxic injections of 6-hydroxydopamine (6-ohda) into the nigrostriatal bundle of marmosets (callithrix jacchus) produced substantial losses of tyrosine hydroxylase immunoreactive neurons from the substantia nigra, and mean dopamine (da) depletions of 98-99% in the caudate nucleus, putamen and nucleus accumbens, and of 91-97% in frontal cortex, on the side of the lesion. noradrenaline (na) and 5-hydroxytryptamine (5-ht) levels were also affected. behavioural tests conducted pre-op ...	1992	1352726
chronic mptp treatment reduces substance p and met-enkephalin content in the basal ganglia of the marmoset.	common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 1.25-2.5 mg/kg s.c., twice a week) for 5-10 consecutive months. the initial doses of mptp produced a severe parkinsonian syndrome but motor activity was partially recovered at the end of treatment. fifteen days or 6 months after the last mptp dose, monkeys were sacrificed. in addition to a strong decrease of dopamine in the striatum, there were significant reductions in substance p and met-enkephalin content i ...	1992	1380867
evidence that most of the radioimmunoassayable inhibin secreted by the corpus luteum of the common marmoset monkey is of a non-dimeric form.	although recent data for several species of primate, including human and marmoset, indicate that the corpus luteum secretes high levels of radioimmunoassayable inhibin, the nature of the immunoreactive (ir) inhibin detected has not been established. in this study, plasma ir-inhibin levels during the ovarian cycle of the marmoset (n = 12 animals) were measured by alpha-subunit-directed inhibin ria, and values were compared with those estimated by a recently developed two-site immunoradiometric as ...	1992	1391341
quantification and excretion profiles of pteridines in primate urine.	biopterin, 6-hydroxymethyl-pterin, isoxanthopterin, neopterin and, pterin were quantified in stress-free collected spontaneous morning urine samples from callithrix jacchus, saguinus fuscicollis, saguinus labiatus, saimiri sciureus, presbytis entellus, cercopithecus albogularis, cercocebus torquatus, macaca fascicularis, hylobates concolor, pongo pygmaeus, and gorilla gorilla. in most species, biopterin was the most frequent urinary pteridine followed by neopterin. sex differences in biopterin a ...	1992	1404333
stimulation of immunoreactive inhibin production by preimplantation embryos during early pregnancy in the marmoset monkey (callithrix jacchus).	the role of the embryo in promoting increased plasma concentrations of immunoreactive inhibin after conception in the marmoset monkey was determined by flushing embryos from the uterus between days 5 and 9 after ovulation (implantation commences on days 11-12). blood samples were taken from each animal (three times a week) after ovulation until the end of the luteal phase. plasma inhibin concentrations were measured using a radioimmunoassay based on antisera against a synthetic fragment of the a ...	1992	1432971
dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling.	the aim was to investigate the influence of long term dietary fish oil consumption on cardiac function in a non-human primate, to elucidate further the basis of the apparently reduced cardiovascular disease mortality associated with its consumption in man.	1992	1451164
polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on peripheral lymphocyte subpopulations of a non-human primate (callithrix jacchus).	non-human primates (callithrix jacchus) were treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) over a period of 30 weeks, and lymphocyte subpopulations of venous blood were monitored using monoclonal antibodies and flow cytometry (facscan). there was no clear-cut change in the total lymphocyte population during this study. in the first part of the study the new-world monkeys (marmosets) were treated for 24 weeks with a weekly dose of 0.3 ng tcdd/kg body wt. at the end of this treatment per ...	1992	1514923
behavioural effects of anxiogenic agents in the common marmoset.	the effects of the anxiogenic agents fg7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer. in response to the human observer, the anxiolytic agent diazepam (0.1-2.5 mg/kg, sc) was shown to reduce the intensity of behav ...	1992	1528937
immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). i. distribution of collagen types i and iii.	the distribution of collagen types i and iii was demonstrated in healthy periodontal tissues of the rat and marmoset using immunofluorescent localization after decalcification of the maxillae and mandiblae in 0.2 n hcl. an intense fluorescence in the alveolar bone and cementum matrix, as well as in the soft periodontal tissue, was demonstrated with anti-collagen type i antibodies. in the gingival connective tissue and in the periodontal ligament thick fibers of collagen type i could be observed. ...	1992	1532200
relative effects of activin and inhibin on steroid hormone synthesis in primate granulosa cells.	ovarian granulosa cells produce inhibin and activin, structurally related proteins with potentials to directly modulate follicular steroidogenesis. the aim of the present study was to compare development-related effects of inhibin-a and activin-a on steroidogenesis in marmoset monkey (callithrix jacchus) granulosa cells. granulosa cells from "immature" (< 1.0 mm diameter) and "mature" (> 2 mm diameter) follicles were incubated in serum-free culture medium for 96 h with and without peptide (1-100 ...	1992	1464664
synergism of nbqx with dopamine agonists in the 6-ohda rat model of parkinson's disease.	advance in understanding of the anatomy, physiology and pharmacology of basal ganglia organisation over the past decade revealed a functional relation between excitatory glutamatergic and the degenerated dopaminergic nigrostriatal transmitter systems which could serve as targets for pharmacological interventions in parkinson's disease. the selective ampa-antagonist nbqx is not effective in animal models of parkinson's disease when given alone but ameliorates parkinsonian symptomatology and enhan ...	1992	1491248
corpus callosum in sexually dimorphic and nondimorphic primates.	the midsagittal area and other morphological measures were taken on the corpus callosum of four different species of primate: macaca mulatta, m. fascicularis, callithrix jacchus, and saguinus oedipus. the first two species are strongly dimorphic, whereas the new world forms show little dimorphism with regard to overall body size, canines, and brain weight. neither total corpus callosal area (totalcc), or other parts of the corpus callosum (cc) showed any significant sexual dimorphism in any of t ...	1992	1562061
the polymorphic photopigments of the marmoset: spectral tuning and genetic basis.	the marmoset (callithrix jacchus jacchus), a south american monkey, is polymorphic for the middle- to long-wave cone photopigments: the three variant pigments have spectral peaks at 543, 556 and 563 nm. comparisons of the deduced amino acid sequences of these pigments indicate that the variations in spectral sensitivity are associated with the presence or absence of hydroxyl-bearing residues at sites 180 and 285; but, in contrast to the additive hypothesis of neitz et al. (1991), we propose that ...	1992	1534748
differences in fatty acid composition of various tissues of the marmoset monkey (callithrix jacchus) after different lipid supplemented diets.	1. the fatty acid composition of different muscles, organs and blood components of the marmoset monkey were examined after long-term feeding of several well defined lipid supplemented diets. 2. similarities between the fatty acid composition of cardiac and skeletal muscles which persisted after all diets suggest that biopsy of skeletal muscle may have an important diagnostic value in this and other primate species. 3. the relationship between the dietary intake of individual fatty acids and thei ...	1992	1348468
analysis of the contraceptive potential of antibodies against native and deglycosylated porcine zp3 in vivo and in vitro.	we have undertaken a comparative analysis of the contraceptive activity of antibodies directed against the porcine sperm receptor zona pellucida antigen (zp3) and its mr = 32,000 polypeptide core (dgzp-32). the strategies employed for this analysis included the induction of active immunity in a primate, the common marmoset, and an in vitro fertilization protocol involving the use of viable human ova. in both experimental situations, antibodies against zp3 were shown to exhibit contraceptive acti ...	1992	1576251
influence of dexamethasone on the rm 3/1-positive macrophages in the peripheral blood and tissues of a new world monkey (the marmoset callithrix jacchus).	subcutaneous injection of the glucocorticoid dexamethasone in the primate callithrix jacchus increased the proportion of the macrophage subtype rm 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. the elevated numbers of rm 3/1-positive cells were seen 24 and 72 h after application and were independent of the dosages used (50 or 150 micrograms/kg). oral administration had no effect. cd4-, cd14- and cdw14-antigen expression of monocytes was not influenced by the dexameth ...	1992	1582709
dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey.	programmed electrical stimulation was used to examine the ability of long-term dietary lipid modulation to influence myocardial vulnerability to the induction of ventricular fibrillation in adult marmoset monkeys (callithrix jacchus). marmosets fed diets supplemented (to a total of 28.5% of the energy as fat) with polyunsaturated fatty acid (pufa)-rich tuna fish oil or sunflower seed oil had significantly elevated mean ventricular fibrillation threshold compared with those fed a saturated animal ...	1992	1595535
the relationship between cone pigments and behavioural sensitivity in a new world monkey (callithrix jacchus jacchus).	microspectrophotometric measurements of visual pigments and behavioural measurements of spectral sensitivity are reported for individual marmosets from 3 family groups. the sex differences and polymorphism that characterise the long-wave cone pigments in this species are well reflected by variations in the behavioural sensitivities. with one exception, the pattern of inheritance is compatible with a genetic model in which the long-wave pigment is specified by a single polymorphic locus on the x- ...	1992	1604855