Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| reevaluation of the teleomorph of the genus histoplasma by ubiquinone systems. | ubiquinone systems of the genus histoplasma and blastomyces dermatitidis were examined and the relationship between the two genera, emmonsiella and ajellomyces, was discussed. ubiquinone systems have been adopted as a useful taxonomic criteria at the generic level for fungi. we investigated ubiquinone systems of sexual and asexual strains of histoplasma species and blastomyces dermatitidis. all the strains of the former group had dihydrogenated ubiquinone-10(q-10(h2] as the major isoprenologue, ... | 1991 | 1795729 |
| detection of antibody responses and delayed dermal hypersensitivity with blastomyces dermatitidis yeast and mycelial lysate antigens. | yeast cell lysate and mycelial lysate antigens prepared from one strain (t-58) of blastomyces dermatitidis were evaluated with respect to the detection of antibodies and delayed dermal hypersensitivity. comparable elisa sensitivity values were evidenced with the two antigens when assayed against serum specimens from dogs with blastomycosis, sera from non-infected dogs residing in endemic and non-endemic areas for blastomycosis and sera from rabbits that were hyperimmunized with b. dermatitidis a ... | 1991 | 1886639 |
| an outbreak of human and canine blastomycosis. | in the summer and fall of 1988, three humans and one dog in a lakeshore community in northern wisconsin were found to have blastomycosis on the basis of the results of cultures and histologic studies; the infection was also suspected in one human and four dogs on the basis of clinical data. serologic testing with use of enzyme immunoassay for antibody to the a antigen of blastomyces dermatitidis was performed for 77 additional human residents and visitors in the area an average of 9 months after ... | 1991 | 1962106 |
| macrophage- and oxidant-mediated inhibition of the ability of live blastomyces dermatitidis conidia to transform to the pathogenic yeast phase: implications for the pathogenesis of dimorphic fungal infections. | conidia, produced by the mycelial phase of dimorphic fungi, are thought to represent the infectious form of the organism but must complete a transition to the tissue-invasive, yeast-like phase for infection to ensue. preventing such transition should effectively eliminate pathogenicity. using blastomyces dermatitidis as a target, murine bronchoalveolar macrophages preferentially blocked phase transition after 4 h of incubation with conidia, relatively sparing the ability of conidia to produce hy ... | 1991 | 1988520 |
| peritoneal blastomycosis. | blastomycosis is a systemic fungal infection caused by blastomyces dermatitidis. involvement of the peritoneum is unusual, with only two previously reported cases that occurred in association with disseminated disease. a single case of histopathologically proven blastomycosis involving the peritoneum is presented, as well as a short overview of previously published cases on gastrointestinal and peritoneal blastomycosis. the case is unique in that chronic peritonitis was the only manifestation of ... | 1991 | 1998318 |
| two cases of blastomycosis from a common source: use of dna restriction analysis to identify strains. | two friends, one with aids, developed severe pulmonary blastomycosis but differed markedly in clinical course. the human immunodeficiency virus-negative patient responded completely to ketoconazole; the patient with aids died of progressive disseminated infection despite treatment with fluconazole and amphotericin b. epidemiologic investigation suggested a common source of infection, but serologic evaluation and environmental cultures were unrevealing. ecori digestion of the blastomyces dermatit ... | 1991 | 1674750 |
| mechanisms of fungal pathogenicity: correlation of virulence in vivo, susceptibility to killing by polymorphonuclear neutrophils in vitro, and neutrophil superoxide anion induction among blastomyces dermatitidis isolates. | seven blastomyces dermatitidis isolates varying in virulence for mice were compared for susceptibility to polymorphonuclear neutrophil (pmn) killing and the ability to induce superoxide anion (o2-) production by pmns in vitro. in vitro killing of six b. dermatitidis isolates by murine peripheral blood pmns or by pmns elicited from the peritoneal cavity by a local immune reaction (b. dermatitidis-immune mice given killed b. dermatitidis intraperitoneally 24 h earlier) inversely correlated with in ... | 1991 | 1649799 |
| concurrent infection with sporotrichosis and blastomycosis: an unusual case. | two facial nodules and a pulmonary infiltrate occurred in a twenty-one-year-old man. tissue cultures from one of the facial lesions showed both sporothrix schenckii and blastomyces dermatitidis. cultures from lung biopsy tissue grew b. dermatitidis. this is the first known reported case of sporotrichosis and blastomycosis occurring concurrently in the same cutaneous lesion. | 1991 | 1935247 |
| blastomycotic cranial osteomyelitis. | this is the second case report of a temporal bone osteomyelitis caused by blastomyces dermatitidis, which presented as a chronic serous otitis media. the presenting serous otitis media was refractory to conventional medical and surgical management and progressed to a temporal bone osteomyelitis prior to diagnosis. b. dermatitidis is a rare fungal pathogen that causes a systemic pyogranulomatous disease that primarily manifests itself in the skin, bones, pulmonary, and genitourinary systems. if l ... | 1992 | 1449188 |
| wi-1, a novel 120-kilodalton surface protein on blastomyces dermatitidis yeast cells, is a target antigen of cell-mediated immunity in human blastomycosis. | a large body of experimental data has demonstrated the central role of t cells in acquired resistance to the dimorphic fungus blastomyces dermatitidis. we examined the human t-cell response to wi-1, a 120-kda b. dermatitidis yeast cell surface protein recently shown to be an immunodominant antigen of the b-cell response in infected humans. peripheral blood lymphocytes from 10 blastomycosis patients studied proliferated in response to wi-1 (mean, 19,431 cpm) and to the standard, crude cell wall a ... | 1992 | 1383148 |
| western immunoblot analysis and serologic characterization of blastomyces dermatitidis yeast form extracellular antigens. | a major 98-kda extracellular protein antigen of blastomyces dermatitidis was shown in western blot (immunoblot) analysis to be highly reactive with serum antibodies from patients with blastomycosis. sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of yeast form b. dermatitidis culture filtrates and cell extracts demonstrated over 50 proteins, only 24 of which were immunoreactive. of these, a 98-kda protein was found to be the most specific and was isolated. this protein was fou ... | 1992 | 1452683 |
| comparative evaluation of a chemiluminescent dna probe and an exoantigen test for rapid identification of histoplasma capsulatum. | a chemiluminescent dna probe (accuprobe) assay developed by gen probe, inc., for the rapid identification of histoplasma capsulatum was evaluated and compared with the exoantigen test by using 162 coded cultures including histoplasma capsulatum var. capsulatum, histoplasma capsulatum var. duboisii, histoplasma capsulatum var. farciminosum, blastomyces dermatitidis, coccidioides immitis, paracoccidioides brasiliensis, and morphologically related saprobic fungi. each test uses a chemiluminescent, ... | 1992 | 1452692 |
| [blastomycosis localized in the brain stem]. | a 33-year old male tunisian developed, without any apparent cause, an abscess of the brainstem which was shown by various mycological investigations to be due to a blastomyces dermatitidis infection. this case is of interest not only because of the exceptional location of the abscess in the brainstem, but also because of its treatment: this was the first case where the fluconazole-flucytosine combination was used against blastomycosis with fully satisfactory results after a 28-month follow-up. | 1992 | 1532086 |
| small subunit ribosomal rna of blastomyces dermatitidis: sequence and phylogenetic analysis. | we determined the small subunit (18s) ribosomal rna sequence of the dimorphic fungus blastomyces dermatitidis. the sequence was compared to that of fourteen other eukaryotic organisms, ten of which were higher fungi, and an evolutionary tree was constructed based on these sequences. b. dermatitidis aligned most closely with the ascomycetes neurospora crassa and podospora anserina, in agreement with previous phylogenetic analysis based on morphological criteria. phase-specific cdna clones derived ... | 1992 | 1564447 |
| splenic abscess caused by blastomyces dermatitidis in association with peritoneal involvement: case report and review. | we report a rare case of a patient with blastomycosis who presented with splenic abscess and peritoneal involvement. this case is unique in that no historical or radiographic evidence of antecedent pulmonary infection was apparent and therapy with orally administered ketoconazole was effective. we reviewed the english-language literature on blastomycotic splenic abscess and compared findings from other cases with findings from the current case. | 1992 | 1571449 |
| blastomycosis in patients with the acquired immunodeficiency syndrome. | to describe the clinical, demographic, radiographic, diagnostic, and therapeutic aspects of blastomycosis in patients with the acquired immunodeficiency syndrome (aids). | 1992 | 1567099 |
| blastomycosis: a reminder of kentucky's other fungus. | although not as common as histoplasmosis, the disease caused by blastomyces dermatitidis is also endemic in the commonwealth of kentucky. greater clinical awareness of this systemic mycosis and the newer effective forms of treatment may lessen the significant morbidity and mortality of this potentially serious infection. to illustrate the varied manifestations of this illness, we contrast the presentation of an urban female with blastomycosis and atypical chest radiographic changes to the more c ... | 1992 | 1479260 |
| molecular evolution of the fungi: human pathogens. | the morphological, ecological, and clinical diversity among ascomycete fungi that are pathogenic to humans suggest that the potential for pathogenicity may have arisen multiple times within these higher fungi. we have obtained 18s ribosomal dna sequences from a diverse group of human pathogenic fungi in order to determine their evolutionary origins. the fungi studied include a skin pathogen that is confined to humans (trichophyton rubrum) and three systemic, facultative parasites that cause hist ... | 1992 | 1528111 |
| viability of fungal cultures maintained at -70 degrees c. | one thousand four hundred forty-seven clinical and environmental isolates of molds, yeasts, aerobic actinomycetes, and algae belonging to 164 genera (382 taxa) maintained on potato dextrose agar at -70 degrees c for periods ranging from 6 months to 13 years were subcultured and then incubated at 25 degrees c to determine their viabilities. thirty-three isolates, alternaria alternata (n = 1), apophysomyces elegans (n = 1), bipolaris spicifera (n = 1), blastomyces dermatitidis (n = 4), cokeromyces ... | 1992 | 1572955 |
| synergy of itraconazole with macrophages in killing blastomyces dermatitidis. | we examined in vitro interaction between the azole antifungal agents itraconazole and ketoconazole and macrophages and their activities against blastomyces dermatitidis. fungistatic and fungicidal concentrations for b. dermatitidis in vitro were assessed in a microculture system in which fungistasis was measured as inhibition of multiplication and fungicidal activity was measured as reduction of inoculum cfu. resident peritoneal murine macrophages, which surround but do not phagocytize the fungu ... | 1992 | 1336949 |
| immunohistologic diagnosis of systemic mycoses: an update. | fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. these methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying therein antigens of infectious dimorphic, monomorphic filamentous, and yeast-like fungal pathogens, i.e., aspergillus spp., blastomyces dermatitidis, candida spp., coccidioides immitis, ... | 1992 | 1397200 |
| chronic fibrosing mediastinitis and superior vena caval obstruction from blastomycosis. | chronic fibrosing mediastinitis is most commonly a complication of granulomatous disease caused by histoplasmosis. we report a case of blastomyces dermatitidis causing superior vena caval obstruction from fibrosing mediastinitis. | 1992 | 1417237 |
| otitis media due to blastomycosis: report of two cases. | blastomycosis as a causative agent in cases of otitis media has not previously been reported. two patients recently presented with otitis media and head and neck masses due to blastomyces dermatitidis. initial evaluation suggested neoplastic disease, but biopsy confirmed a fungal etiology for the masses in both patients. relapse after administration of ketoconazole was noted in one patient, who was an adult; the other patient was a child. otitis media and masses of the head and neck are unusual ... | 1992 | 1571452 |
| recognition of histoplasma capsulatum yeast-cell antigens by human lymphocytes and human t-cell clones. | we have prepared a detergent extract from the cell wall and cell membrane of histoplasma capsulatum yeast cells that is recognized by t cells from mice immunized with viable organisms or with the extract. a 62-kd antigen from this extract has been isolated and has been shown to be antigenic and to confer protective immunity in mice. in this study, we examined the in vitro proliferative response by human lymphocytes and human t-cell clones to both the extract from the cell wall and cell membrane ... | 1992 | 1602236 |
| evaluation of a commercial dna probe assay for the identification of clinical isolates of blastomyces dermatitidis from dogs. | a dna probe assay (accuprobe, gen-probe, inc., san diego, ca) for culture confirmation of blastomyces dermatitidis in clinical isolates was evaluated using 72 isolates of b. dermatitidis (62 dog isolates, five from other animals, four human isolates and one soil isolate). in addition, specificity determinations were performed using 28 american type culture collection (atcc) fungal isolates, other than b. dermatitidis, representing 21 different genera. the non-isotopic hybrid protection assay, th ... | 1992 | 1573520 |
| evaluation of new antifungal drugs for the treatment of systemic fungal infections. infectious diseases society of america and the food and drug administration. | these guidelines are applicable to all fungal pathogens that produce systemic infections in humans. specific examples are provided whenever they might clarify special issues. systemic fungal infections usually are divided into two broad categories: endemic systemic fungal diseases, which occur classically in healthy hosts, and opportunistic fungal diseases, which occur almost exclusively in patients with impaired host defenses. both the increasing frequency of disseminated histoplasmosis and coc ... | 1992 | 1477243 |
| a basis for resistance of blastomyces dermatitidis killing by human neutrophils: inefficient generation of myeloperoxidase system products. | the mechanism by which the yeast form of blastomyces dermatitidis resists killing by human peripheral blood polymorphonuclear neutrophils (pmn) was investigated. the metabolic products of the oxidative burst generated during the interaction of pmn and b. dermatitidis or candida albicans were detected by lucigenin- or luminol-enhanced chemiluminescence (cl). interaction of pmn and c. albicans resulted in luminol-enhanced cl 100-fold greater than that generated by pmn and b. dermatitidis. this cor ... | 1992 | 1325554 |
| combined histochemical stains in the differential diagnosis of cryptococcus neoformans. | three combinations of histochemical stains were used to study 69 routinely processed tissues containing various "yeast-like" fungal organisms (cryptococcus neoformans, blastomyces dermatitidis, coccidioides immitis, histoplasma capsulatum, paracoccidioides brasiliensis, and candida albicans). fontana-masson stain combined either with mucicarmine or alcian blue produced distinctive staining of c. neoformans (fontana-masson-positive wall and mucin-positive capsule) that was not identified in other ... | 1993 | 7678937 |
| production of a murine monoclonal antibody that recognizes an epitope specific to coccidioides immitis antigen 2. | antigen 2 (ag2) has been implicated as a t-cell-reactive component of the pathogenic fungus coccidioides immitis. we report the production of a murine monoclonal antibody (mab) of the immunoglobulin g2a isotype that recognizes an epitope specific to c. immitis ag2. this specificity was evidenced by the finding that the mab did not recognize other antigens present in coccidioidin or spherulin and did not show reactivity with antigenic extracts from histoplasma capsulatum or blastomyces dermatitid ... | 1993 | 7682998 |
| il-4, ige, and interferon-gamma production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (sch 39304). | the purpose of this study was to determine if there is a correlation between production of certain lymphokines in progressive blastomycosis in untreated mice, resistance to infection in immunized mice, and cure in antifungal triazole (sch 39304)-treated mice. infection was measured by colony-forming units of blastomyces dermatitidis in lungs. serum level of ige was used as a marker for in vivo il-4 activity. serum ige levels rose in untreated mice from 6 micrograms/ml at 3 weeks to 24 micrograms ... | 1993 | 7687197 |
| pulmonary sequestration with primary blastomycosis. failure of ketoconazole therapy after resection. | infection with blastomyces dermatitidis developed in a girl with occult pulmonary sequestration. six months after resection, while receiving ketoconazole, she developed an abscess due to b dermatitidis over the scar from thoracotomy, with a sinus tract to the eighth rib. this was successfully managed with débridement, rib resection, and amphotericin b. contiguous bone involvement should be suspected in sequestra infected with this organism; débridement and therapy with amphotericin b might be in ... | 1993 | 8131493 |
| therapeutic efficacy of a liposomal formulation of amphotericin b (ambisome) against murine blastomycosis. | the efficacy of a liposomal amphotericin b preparation (ambisome) and a deoxycholate suspension (fungizone) were compared in a pulmonary model of murine blastomycosis. male, four-week-old cd-1 mice were infected intranasally with 19,400 or 27,450 cfu of viable blastomyces dermatitidis yeasts and intravenous therapy begun 4 days later. groups of ten mice were given various dosages of fungizone or ambisome or were untreated. all treatments were given 3 times per week for 2 weeks. deaths were recor ... | 1993 | 8262869 |
| histoplasmosis. | histoplasmosis is an infection caused by the dimorphic fungus, histoplasma capsulatum. the initial site of entry is usually the lung, but dissemination to skin occurs in some patients, particularly those with human immunodeficiency virus (hiv) infection in whom it is part of a widespread infection. the organisms have to be distinguished from other yeasts in skin such as cryptococcus neoformans and small forms of blastomyces dermatitidis. | 1993 | 8312147 |
| immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of blastomyces dermatitidis. | a 120-kd glycoprotein antigen abundantly expressed on blastomyces dermatitidis yeasts is a target of cellular and humoral immune responses in human infection. to investigate the antigen and immune response more carefully at the molecular level, we screened an expression library from b. dermatitidis to identify clones that encode this antigen, designated wi-1. a 942-bp cdna was isolated by immunologic screening with polyclonal, rabbit anti-wi-1 antiserum. northern hybridization analysis showed th ... | 1993 | 8326001 |
| two-dimensional immunoelectrophoresis of histoplasmin and a purified polysaccharide-protein antigen of histoplasma capsulatum. | crude histoplasmin and a polysaccharide-protein complex (ppc-histo) antigens obtained from culture filtrates of histoplasma capsulatum were analyzed by single and tandem two-dimensional immunoelectrophoresis (td-iep) using a rabbit hyperimmune anti-histoplasmin polyvalent serum. single td-iep showed 14 arc precipitates for histoplasmin. continuity of arcs 2, 6, and 7, and 9 and 10 was observed, suggesting a different polymeric configuration of the same antigen. this was also confirmed in tandem ... | 1993 | 8326996 |
| reactivation and dissemination of blastomycosis complicating hodgkin's disease: a case report and review of the literature. | patients presenting with hodgkin's disease (hd) may show lung involvement characterized by contiguous spread from ipsilateral hilar lymph nodes. lung consolidation or noncontiguous pulmonary involvement makes an alternative diagnosis more likely. this report describes a patient with hd in whom concurrent pulmonary blastomycosis was recognized only after chemotherapy had started and dissemination had occurred. although blastomyces dermatitidis may behave as an opportunist pathogen, there are no p ... | 1993 | 8342540 |
| overwhelming pulmonary blastomycosis associated with the adult respiratory distress syndrome. | few cases of overwhelming pulmonary blastomycosis associated with the adult respiratory distress syndrome have been reported. we describe 10 patients with this condition who were treated at one center in wisconsin. | 1993 | 8413389 |
| gallium-67-citrate and bone scintigraphy in disseminated north american blastomycosis. | we present a patient with north american blastomycosis involving lung and bone. chest radiographs and ct scan showed a mass in the lung. bone scintigraphy detected a photon-deficient area in the sternum and 67ga spect showed uptake in the right upper lung and in the sternum. a diagnostic thoracotomy and needle biopsy from the sternal lesion revealed granulomatous infection due to blastomyces dermatitidis. after 3 mo of antifungal therapy, the follow-up 67ga study showed no evidence of the origin ... | 1993 | 8441039 |
| disseminated atypical blastomycosis in two patients with aids. | two men with aids developed fungal infections and subsequently died as a result of dissemination of the fungal infection. findings obtained by histologic examination, serological studies, and cultures suggested that the infections were caused by blastomyces dermatitidis. tissue sections showed polymorphic yeast-like cells 5-20 microns in diameter (some with broad and others with narrow single- or multiple-based buds), small yeasts, and hyphal elements. the exoantigen k positivity and exoantigen ... | 1993 | 8448284 |
| blastomycosis in transplant recipients: report of a case and review. | fungi cause serious, often fatal infections in immunocompromised hosts. recipients of solid organ and bone marrow transplants are predisposed to invasive fungal infections with candida species, aspergillus species, and cryptococcus neoformans. in contrast, infections with blastomyces dermatitidis have rarely been diagnosed in transplant recipients. we describe a patient who received an orthotopic heart transplant and developed recurrent disseminated blastomycosis. other reported cases of blastom ... | 1993 | 8448319 |
| evaluation of commercially available acridinium ester-labeled chemiluminescent dna probes for culture identification of blastomyces dermatitidis, coccidioides immitis, cryptococcus neoformans, and histoplasma capsulatum. | four commercially available acridinium ester-labeled dna probes directed against rrna were evaluated for their ability to identify blastomyces dermatitidis, coccidioides immitis, histoplasma capsulatum, and cryptococcus neoformans in culture. rrna was extracted by sonication of 1- to 2-mm2 portions of cultures of fungi in two chaotropic reagents with glass beads. following a heat inactivation step, the extracts were hybridized in solution with probes specific for each pathogen. the acridinium es ... | 1993 | 8463395 |
| unpredictability of commercially available exoantigen culture confirmation tests in confirming the identity of five blastomyces dermatitidis isolates. | colonial and microscopic features of five fungal isolates from three patients suggested blastomyces dermatitidis. extracts from the mold forms of all isolates were tested on several occasions with commercially available exoantigen immunodiffusion culture-confirmation test reagents and nolan reagents. all three isolates from patient 1 were negative on four separate attempts with exoantigen reagents using conventional ("slant") and "broth" extraction methods, and were also negative on one attempt ... | 1993 | 8493947 |
| activities of the triazole d0870 in vitro and against murine blastomycosis. | the novel triazole d0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. in vitro, d0870 had inhibitory and fungicidal activity against blastomyces dermatitidis (mic = 0.048 microgram/ml; minimal fungicidal concentration = 0.097 microgram/ml). in vivo, d0870 was approximately 100-fold more active than fluconazole on the basis of milligrams per kilogram of body weight given once daily (qd) against blastomycosis. d0870 doses of both 1 or 10 mg/kg ... | 1993 | 8517710 |
| acanthamoeba infection presenting as skin lesions in patients with the acquired immunodeficiency syndrome. | acanthamoeba organisms are a well-known, although rare, cause of central nervous system infection in immunodeficient hosts, including those with the acquired immunodeficiency syndrome. extracerebral acanthamebiasis, with the exception of contact lens-associated keratitis, is reported but little emphasized in the literature. we describe two patients with the acquired immunodeficiency syndrome in whom skin lesions were the primary manifestations of acanthamoeba infection. central nervous system di ... | 1993 | 8215828 |
| biological properties of aureobasidin a, a cyclic depsipeptide antifungal antibiotic. | aureobasidin a (aba) is a novel cyclic depsipeptide antifungal antibiotic. the antifungal activity of aba was studied in vitro and in vivo in comparison with clinically effective antifungal agents, amphotericin b and fluconazole. aba was highly active in vitro against many pathogenic fungi, including candida albicans, cryptococcus neoformans, blastomyces dermatitidis and histoplasma capsulatum. the activity was superior to amphotericin b in most cases. aba exhibited fungicidal action toward grow ... | 1993 | 8226319 |
| fluconazole (diflucan): a review. | fluconazole is a triazole antifungal agent available for oral or intravenous use in the treatment of a number of localized and disseminated mycoses. animal models have shown in vivo activity against infections caused by candida spp. and crytococcus neoformans. fluconazole is also active in animal infections caused by blastomyces dermatitidis, coccidioides immitis, histoplasma capsulatum, and dermatophytes. fluconazole acts by inhibiting synthesis of ergosterol, an essential sterol in fungal cell ... | 1993 | 18611557 |
| blastomycosis in quebec (1981-90): report of 23 cases and review of published cases from quebec. | twenty-three cases of blastomycosis were reported in a survey conducted in the province of quebec from 1981-90. thirteen patients resided south of the st lawrence river and the other 10, north. two small geographical clusters were apparent in and around the cities of sherbrooke and quebec. the male to female ratio was 1.6:1 and the median age was 47 years (range 26 to 77). lung involvement was observed in 19 cases and was the only site involved in 11. cutaneous manifestations were reported in 11 ... | 1993 | 22346428 |
| macrophages and blastomyces dermatitidis. | 1994 | 8251594 | |
| development of pulmonary infection in mice inoculated with blastomyces dermatitidis conidia. | intratracheal injection of balb/cbyj mice with 10(4) blastomyces dermatitidis conida produces chronic pulmonary and disseminated blastomycosis characterized by pyogranulomatous inflammation. to study the evolution of the pulmonary infection, mice were killed at varying intervals after inoculation, their lungs cultured and examined histologically. nodular intraalveolar infiltrates of macrophages (m phi) were seen on day 1 with occasional admixed polymorphonuclear leukocytes (pmn). phagocytized ye ... | 1994 | 8306053 |
| cloning and characterization of bys1, a temperature-dependent cdna specific to the yeast phase of the pathogenic dimorphic fungus blastomyces dermatitidis. | the pathogenic dimorphic fungal organism blastomyces dermatitidis exists as a budding yeast at 37 degrees c and as a mycelium at 25 degrees c. while the conversion of one morphological phase of b. dermatitidis to another has long been known to be a thermally dependent process, little of the accompanying biochemical or genetic events controlling the phase transition has been elucidated. using differential cdna library screening, we have identified one transcript, bys1, in b. dermatitidis that is ... | 1994 | 8188377 |
| delayed treatment of pulmonary blastomycosis causing vertebral osteomyelitis, paraspinal abscess, and spinal cord compression. | a 36-year-old woman with gallbladder disease had an incidental finding of asymptomatic cavitary lung infection with blastomyces dermatitidis. no treatment was given initially, and 2 months later she presented with vertebral osteomyelitis, paraspinal abscess, and spinal cord compression due to dissemination of the fungus. the patient recovered following surgical debridement and treatment with 1 g of amphotericin b, followed by itraconazole 400 mg qd for 6 months. in spite of previous reports of t ... | 1994 | 8191232 |
| altered expression of surface protein wi-1 in genetically related strains of blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages. | the molecular basis for pathogenicity and virulence of the dimorphic fungus blastomyces dermatitidis remains unknown. wi-1 is a major cell wall protein of b. dermatitidis yeasts and is a recognition target of both humoral and cell-mediated immunity. as an initial study to determine if wi-1 might be linked to virulence of b. dermatitidis, we quantified wi-1 expression on three genetically related strains that differ in their virulence for mice: wild-type virulent atcc strain 26199, mutant atcc st ... | 1994 | 8039924 |
| blastomyces dermatitidis infection of the paranasal sinuses. | 1994 | 8161650 | |
| us case of the day. right epididymo-orchitis due to disseminated blastomyces dermatitidis. | 1994 | 7938782 | |
| utility of anti-wi-1 serological testing in the diagnosis of blastomycosis in wisconsin residents. | wi-1, a 120-kd protein found in the outer cell wall of blastomyces dermatitidis, has been purified, labeled with 125i, and used as a target in a radioimmunoassay (ria). in an assessment of the usefulness of anti-wi-1 serology in the diagnosis of blastomycosis, the ria was used to test four panels of sera from residents of wisconsin, a state in which blastomycosis is endemic. twenty-four (75%) of 32 patients whose blastomycosis had been reported to the wisconsin division of health had at least on ... | 1994 | 7948563 |
| brain abscess caused by blastomyces dermatitidis in a child with cystic fibrosis. | an 8-year-old girl with moderately severe cystic fibrosis and right upper lobe bronchiectasis developed a cerebellar abscess caused by blastomyces dermatitidis. to our knowledge, this is the youngest child with cystic fibrosis and a brain abscess, and the first documented case caused by a fungus. | 1994 | 7774344 |
| phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal rna sequence comparisons. | the phylogeny of dermatophytes and dimorphic fungi was considered using the large-subunit of ribosomal rna (25s rrna). aligned sequences of 595 nucleotides covering the two most divergent domains d1 and d2, permitted a comparison of phylogenetic relationships at different levels. the dimorphic species (onygenaceae) were significantly separated from dermatophytes (arthrodermataceae) and from a third group including geophilic or very weakly pathogenic species (onygenaceae and gymnoascaceae). on a ... | 1994 | 7844699 |
| comparative studies on the detection of delayed dermal hypersensitivity in experimental animals with lysate and filtrate antigens of blastomyces dermatitidis. | yeast cell and mycelial lysate and filtrate antigens prepared in our laboratory from two strains of blastomyces dermatitidis (canine isolate t-58 and human isolate le) were evaluated with respect to the detection of delayed dermal hypersensitivity in hairless guinea pigs previously immunized with killed whole yeast cells from two strains of blastomyces dermatitidis (t-58 and le) and histoplasma capsulatum (strain g-217a). the optimal potential reactivity (reactivity minus cross-reactivity) with ... | 1994 | 7898509 |
| comparative evaluation of chemiluminescent dna probe assays and exoantigen tests for rapid identification of blastomyces dermatitidis and coccidioides immitis. | chemiluminescent dna probe (accuprobe) assays developed by gen-probe, inc. (san diego, calif.), for the rapid identification of blastomyces dermatitidis and coccidioides immitis were evaluated and compared with the exoantigen test by using 74 mycelial cultures of b. dermatitidis and 72 mycelial cultures of c. immitis. seventeen isolates of the dimorphic pathogen paracoccidioides brasiliensis were included because of their gross morphologic and antigenic relatedness to b. dermatitidis. the hetero ... | 1994 | 8027336 |
| altered expression of surface alpha-1,3-glucan in genetically related strains of blastomyces dermatitidis that differ in virulence. | recent studies of the dimorphic fungal pathogens histoplasma capsulatum and paracoccidioides brasiliensis have suggested a role in virulence for the cell surface carbohydrate alpha-(1,3)-glucan. to investigate a possible basis for alpha-(1,3)-glucan in the pathogenicity and virulence of the dimorphic fungus blastomyces dermatitidis, we examined three genetically related strains of b. dermatitidis that differ in their virulence for mice: wild-type virulent strain atcc 26199; mutant strain atcc 60 ... | 1994 | 8039925 |
| purification and characterization of the major antigen wi-1 from blastomyces dermatitidis yeasts and immunological comparison with a antigen. | the lack of well-defined antigens from blastomyces dermatitidis has hampered the ability to reliably diagnose human infection and study the immunobiology of blastomycosis. we recently discovered a novel surface protein on b. dermatitidis yeasts, designated wi-1, and demonstrated it to be a key antigenic target of humoral and cellular responses during infection. in the present article, we purified and characterized wi-1 and compared it immunologically with the only blastomyces antigen commerciall ... | 1994 | 7520423 |
| newer developments in therapy for endemic mycoses. | in the 1960s and 1970s, amphotericin b was the only effective therapy for serious systemic endemic fungal infections due to histoplasma capsulatum, blastomyces dermatitidis, and sporothrix schenckii. in the 1980s, ketoconazole was introduced as therapy for endemic mycoses; after this antifungal agent was introduced, some of these infections could be treated orally in an outpatient setting rather than intravenously in an inpatient setting. the 1990s have become the triazole era. it is now standar ... | 1994 | 7948568 |
| comparative stability, sensitivity and specificity studies with different lots of blastomyces dermatitidis yeast and mycelial lysate antigens. | comparative studies were performed to assess the stability and lot-to-lot variation of blastomyces dermatitidis yeast and mycelial phase lysate antigens. four lots were prepared from each growth phase of b. dermatitidis strain t-58 (canine isolate) during a 14-month period. serum specimens from dogs with blastomycosis, histoplasmosis, coccidioidomycosis, cryptococcosis and aspergillosis were assayed for antibody content using an alkaline phosphatase enzyme-linked immunosorbent assay (elisa). the ... | 1994 | 7898510 |
| evidence for a phylogenetic connection between coccidioides immitis and uncinocarpus reesii (onygenaceae). | coccidioides immitis is an anomaly amongst the human systemic fungal pathogens. its unique parasitic cycle has contributed to confusion over its taxonomy. early investigators mistakenly suggested that the pathogen is a protist, while others agreed it to be a fungus but placed it in four different divisions of the eumycota. the taxonomy of c. immitis is still unresolved. ultrastructural examinations of its parasitic and saprobic phases have revealed features that are diagnostic of the ascomycetou ... | 1994 | 7915941 |
| intraocular blastomycosis: case report and review. | intraocular infection due to blastomyces dermatitidis is rare, and only 10 cases have previously been reported. manifestations of ocular blastomycosis can range from keratitis to panophthalmitis, and it is often difficult to diagnose ocular blastomycosis early. we report the case of a 45-year-old man who had disseminated blastomycosis that involved the lungs, skin, and ocular uvea and who was successfully treated with systemic and local antifungal therapy. we also review the literature describin ... | 1994 | 8075276 |
| marked polymorphonuclear pleocytosis due to blastomycotic meningitis: case report and review. | meningitis is an unusual manifestation of infection caused by blastomyces dermatitidis. we describe a patient who presented with fulminant blastomycotic meningitis. examination of the lumbar csf demonstrated > 5,000 polymorphonuclear leukocytes/mm3. the diagnosis of b. dermatitidis meningitis was initially suggested by cytologic examination of csf and confirmed by culture. pleocytosis of this magnitude had not been previously described in association with blastomycosis, although review of the pu ... | 1994 | 8075280 |
| double-stranded rna virus in the human pathogenic fungus blastomyces dermatitidis. | double-stranded rna viruses were detected in a strain of blastomyces dermatitidis isolated from a patient in uganda. the viral particles are spherical (mostly 44 to 50 nm in diameter) and consist of about 25% double-stranded rna (5 kb) and 75% protein (90 kda). the virus contains transcriptional rna polymerase activity; it synthesized single-stranded rna in vitro in a conservative manner. the newly synthesized single-stranded rna was a full-length strand, and the rate of chain elongation was app ... | 1994 | 7933142 |
| [cutaneopulmonary blastomycosis]. | we observed a new case of blastomycosis in a patient with haemoptysis. the chest x-ray revealed a lesion confined to the upper right lobe of the lung and there was an ulcerating vegetation at the medial angle of the right eye. skin biopsy and bronchial aspiration led to the identification of typical blastomyces dermatitidis. outcome was favourable after oral therapy with ketoconazole. cutaneo-pulmonary blastomycosis is weakly endemic in tunisia. pulmonary lesions are more frequent because of air ... | 1994 | 7979035 |
| extrapulmonary thoracic disease caused by blastomyces dermatitidis. | a case of blastomycosis is reported involving the mediastinum and compromising the plexus brachialis. the pathology, pathophysiology, and treatment of this patient and of a previously reported patient are discussed and compared with the characteristics of extrapulmonary thoracic disease caused by histoplasmosis. because of the favorable response of these patients to prolonged antifungal therapy, blastomycosis should be considered in the differential diagnosis of invasive extrapulmonary thoracic ... | 1994 | 7988217 |
| blastomycosis of the forearm synovium in a child. | blastomyces is a pathogen that may infect healthy and immunocompromised hosts. frequently entering the lungs, the initial pneumonitis usually is followed by skin and bony involvement secondary to hematogenous spread. infection of the synovium without bone or skin involvement in the pediatric population has not been reported previously. a soft tissue mass of the forearm in a 9-year-old boy was the initial manifestation of blastomycosis. radiographic images, ultrasound, and magnetic resonance imag ... | 1995 | 7671483 |
| the wi-1 antigen of blastomyces dermatitidis yeasts mediates binding to human macrophage cd11b/cd18 (cr3) and cd14. | three genetically related strains of blastomyces dermatitidis (bd) yeasts that differ in their expression of wi-1, an immunodominant cell wall ag, were tested for their capacity to bind to human macrophages (m phi) in the absence of serum. these strains included american type culture collection (atcc, rockville, md) atcc 26199, which is virulent for mice; an attenuated mutant strain atcc 60915, which expresses 2.5-fold more wi-1 than strain 26199; and an avirulent mutant strain, atcc 60916, whic ... | 1995 | 7529285 |
| unraveling the secrets of histoplasma capsulatum. a model to study morphogenic adaptation during parasite host/host interaction. | early in the developmental period of microbiology, pasteur first observed the phenomenon of dimorphism in fungi when he noticed that the bread mold mucor grew as a filamentous mold aerobically on the surface of broth cultures but at the bottom of the flask where the environment was anaerobic it reproduced as budding yeast cells. several infectious fungal pathogens of humans, namely histoplasma capsulatum, blastomyces dermatitidis, paracoccidioides brasiliensis, sporothrix schenkii, and coccidioi ... | 1995 | 7571855 |
| detection of specific antibodies in human blastomycosis by enzyme immunoassay. | serologic tests for the diagnosis of blastomycosis have had inadequate sensitivity, but results are improved with enzyme immunoassay (eia) with a-antigen of blastomyces dermatitidis. the premier blastomyces eia kit (meridian diagnostics inc, cincinnati, ohio) detected antibody against the b dermatitidis a-antigen in sera from 104 of 125 patients (83%) with culture-proven blastomycosis. semiquantitative index values (positivity multiplied by the dilution) ranged from 1.0 to 423.3; the degree of p ... | 1995 | 7502120 |
| treatment of murine pulmonary blastomycosis with sch 51048, a broad-spectrum triazole antifungal agent. | the in vitro and in vivo activities of a new broad-spectrum triazole derivative, sch 51048, against blastomyces dermatitidis were evaluated. as determined by using the new national committee for clinical laboratory standards proposed standard for susceptibility testing of yeasts, sch 51048 was the most active of the four agents tested in vitro against 13 strains of b. dermatitidis. in a well-described murine model of acute pulmonary blastomycosis, sch 51048 was comparable to amphotericin b and a ... | 1995 | 7786012 |
| pediatric spinal blastomycosis: case report. | a 5-year-old male patient presented with flank pain, limping, weight loss, and cachexia. magnetic resonance imaging revealed destructive vertebral changes, an epidural mass, psoas abscesses, and lack of involvement of the disc spaces. blastomyces dermatitidis was isolated from a needle aspiration specimen. sparing of the disc spaces, an unusual finding, suggested that the spread of infection was by way of paravertebral structures and surrounding potential spaces. management was simplified by usi ... | 1995 | 7501124 |
| cloning and nucleotide sequence of a specific dna fragment from paracoccidioides brasiliensis. | we cloned and sequenced a species-specific 110-bp dna fragment from paracoccidioides brasiliensis. the dna fragment was generated by pcr with primers complementary to the rat beta-actin gene under a low annealing temperature. comparison of the nucleotide sequence, after excluding the primers, with those in the genbank database identified approximately 60% homology with an exon of a major surface glycoprotein gene from pneumocystis carinii and a fragment of unknown function in saccharomyces cerev ... | 1995 | 7650207 |
| induction and detection of delayed dermal hypersensitivity in guinea-pig immunized with blastomyces dermatitidis lysate and filtrate antigens. | guinea-pigs were immunized using yeast phase antigens (lysate and filtrate preparations) from two strains of blastomyces dermatitidis (t-58 and le). following a sensitization period, the animals were skin tested on days 40 and 216 using t-58 and le yeast and mycelial phase lysate and filtrate antigen preparations for the detection of delayed dermal hypersensitivity (dth). using the friedman's analysis of variance by rank test, significant differences were found in the efficacy of the immunogens ... | 1995 | 7650574 |
| the value of the premier enzyme immunoassay for diagnosing blastomyces dermatitidis infections. | one hundred and three sera drawn from 20 proven and 65 suspected cases of blastomycosis were examined concurrently with the enzymes immunoassay and microimmunodiffusion tests for the 'a' antibody specific for blastomyces dermatitidis. results indicated that all 20 proven sera were positive by both these tests. thirteen of the 65 sera from suspected blastomycosis cases were positive by the enzyme immunoassay only, whereas none reacted positively in the micro-immunodiffusion test. eighteen sera fr ... | 1995 | 7658303 |
| treatment of blastomycosis with fluconazole: a pilot study. the national institute of allergy and infectious diseases mycoses study group. | there are few clinical data concerning the use of fluconazole, a triazole antifungal agent with in vitro activity against blastomyces dermatitidis, in the treatment of human blastomycosis. we conducted a multicenter, randomized, open-label pilot trial comparing two daily doses of fluconazole (200 mg and 400 mg) in the treatment of non-life-threatening, non-cns blastomycosis. twenty-four patients were enrolled in the study, and 23 patients were evaluable for efficacy analysis. overall, treatment ... | 1995 | 7742428 |
| thoracic mycoses from endemic fungi: radiologic-pathologic correlation. | the endemic fungi histoplasma capsulatum, blastomyces dermatitidis, and coccidioides immitis are primary human pathogens whose major portal of entry is the respiratory tract. their clinical manifestations are categorized as acute, chronic or chronic progressive, or disseminated fungal disease. most acute pulmonary infections are self-limited, and many are asymptomatic. chronic, progressive, or disseminated disease is much less common and most often occurs in immunocompromised patients. the radio ... | 1995 | 7761632 |
| interactions between human bronchoalveolar macrophages and blastomyces dermatitidis conidia: demonstration of fungicidal and fungistatic effects. | the effects of human bronchoalveolar macrophages (bams) on blastomyces dermatitidis conidia were investigated. macrophage monolayers were incubated for 5 days with or without interferon (ifn)-gamma or macrophage colony-stimulating factor (m-csf) before challenge with conidia for 48 h at 37 degrees c. hyphal growth (germination) was inhibited 12% by resident bams (p < .05). in contrast, resident bams blocked conidial phase transition by 88% (p < .05). intermediate forms, aggregates of large cells ... | 1995 | 7769292 |
| bronchoalveolar lavage for diagnosis of fungal disease. five years' experience in a southern united states rural area with many blastomycosis cases. | to determine the relative frequency of blastomyces dermatitidis among other microorganisms in bronchoalveolar lavage (bal) specimens. | 1995 | 7483983 |
| the endemic mycoses: surgical considerations. | surgical consultation is regularly requested for diagnosis and treatment of pulmonary complications of the endemic mycosis, histoplasma capsulatum, blastomyces dermatitidis and coccidioidomycosis immitis, and the yeast cryptococcus neoformans. all resemble pulmonary malignancies. histoplasmosis causes pericarditis, mediastinal fibrosis and mediastinal granuloma, which can cause entrapment of vascular structures, the esophagus, and the trachea. coccidioidomycosis can cause spontaneous pneumothora ... | 1995 | 7612761 |
| genetic diversity in clinical isolates of the dimorphic fungus blastomyces dermatitidis detected by a pcr-based random amplified polymorphic dna assay. | blastomyces dermatitidis is a dimorphic fungus causing localized or systemic infection in areas where the organism is endemic in the central and southeastern united states. in this study, 19 independent isolates of b. dermatitidis from little rock, ark., were grouped into three classes based on restriction fragment length polymorphism patterns in mitochondrial dna with a heterologous probe from histoplasma capsulatum. one large class of 15 isolates and two smaller classes (classes 2 and 3), each ... | 1995 | 7559971 |
| cytologic findings in 43 cases of blastomycosis diagnosed ante-mortem in naturally-infected dogs. | a retrospective study of the cytology of blastomycosis was undertaken. sixty-one samples from 43 naturally infected dogs diagnosed ante-mortem by means of cytology were reviewed. skin and lymph nodes rendered the highest number of positive samples with 17 out of 18 and 14 out of 17 respectively. transtracheal washes contained the tissue forms of blastomyces dermatitidis in 3 out of 5 samples. pyogranulomatous inflammation was diagnosed in 38 of the 61 samples, and of these, 25 cases contained mu ... | 1995 | 8532060 |
| molecular probes for diagnosis of fungal infections. | we have developed 21 specific nucleic acid probes which target the large subunit rrna genes from aspergillus flavus, aspergillus fumigatus, aspergillus glaucus, aspergillus niger, aspergillus terreus, blastomyces dermatitidis, candida albicans, candida (torulopsis) glabrata, candida guilliermondii, candida kefyr, candida krusei, candida lusitaniae, candida parapsilosis, candida tropicalis, coccidioides immitis, cryptococcus neoformans var. gattii, cryptococcus neoformans var. neoformans, filobas ... | 1995 | 8576345 |
| sensitivity and specificity of an isoelectric focusing fraction of blastomyces dermatitidis yeast lysate antigen for the detection of canine blastomycosis. | blastomyces dermatitidis yeast lysate antigen (t-58, dog isolate) fractions prepared using the rotofor preparative isoelectric focusing (ief) cell (bio-rad) were compared with b. dermatitidis yeast lysate and filtrate reagents with respect to the detection of antibodies in sera from dogs with blastomycosis, histoplasmosis, coccidioidomycosis, cryptococcosis and aspergillosis. a horseradish peroxidase enzyme immunoassay with turbo tmb substrate was used in the study. one particular ief fraction ( ... | 1995 | 8531928 |
| genomic cloning, characterization, and functional analysis of the major surface adhesin wi-1 on blastomyces dermatitidis yeasts. | wi-1 is a 120-kda surface protein adhesin on blastomyces dermatitidis yeasts that binds cd18 and cd14 receptors on human macrophages. we isolated and analyzed a clone of genomic wi-1 to characterize this key adherence mechanism of the yeast. the 9.3-kilobase insert contains an open reading frame of 3438 nucleotides and no introns. the amino acid sequence of native wi-1 matches the deduced sequence of genomic wi-1 at positions 757-769, 901-913, and 1119-1138, demonstrating the cloned gene is auth ... | 1995 | 8530512 |
| detection of antibodies and delayed hypersensitivity with rotofor preparative ief fractions of blastomyces dermatitidis yeast phase lysate antigen. | blastomyces dermatitidis (dog isolate t-58) yeast phase lysate antigen was concentrated and separated by rotofor preparative isoelectric focusing cell (bio-rad). the ph values of the fractions were determined and equilibrated to ph 7.2 and then analysed by enzyme-linked immunosorbent assay using horseradish peroxidase enzyme system against serum specimens from dogs with blastomycosis, histoplasmosis, aspergillosis, and coccidioidomycosis. the results showed a peak absorbance at ph 3.89-4.31 (fra ... | 1995 | 8531017 |
| macroscopic and microscopic characteristics of an african blastomyces dermatitidis strain. | this report describes the macro- and microscopic characteristics of a strain of blastomyces dermatitidis isolated in an italian hospital from a libyan patient suffering from cutaneous blastomycosis. the fungus was isolated with great difficulty because of the presence of a proteus species on the lesion. conversion of the mycelial into the yeast-like phase achieved the best results, using columbia anc culture medium. after 5-6 days, this transformation was only partial and presented swollen hypha ... | 1995 | 8720199 |
| blastomycosis presenting as multiple splenic masses. | blastomyces dermatitidis is a fungus that causes a wide spectrum of disease in humans. the clinical and pathological entity of splenic abscess due to blastomycosis is extremely rare. a case of splenic blastomycosis is reported, and its cytopathological and radiological features are described. | 1995 | 22514387 |
| role of cell-surface molecules of blastomyces dermatitidis in host-pathogen interactions. | the fungal pathogen blastomyces dermatitidis produces an adhesin (wi-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus. | 1996 | 8795162 |
| human pathogeneic fungi and their close nonpathogenic relatives. | in order to understand the relationships between human pathogenic fungi and their close, nonpathogenic relatives, we compared small-subunit ribosomal dna sequences among four closely related pathogens, histoplasma capsulatum, blastomyces dermatitidis, trichophyton rubrum, and coccidioides immitis, and seven nonpathogenic fungi expected on morphological grounds to be their nearest relatives. we sequenced small-subunit rna genes from these fungi and used both genetic distance and parsimony algorit ... | 1996 | 8812309 |
| blastomycosis in children. | infections due to blastomyces dermatitidis are not commonly encountered in children and adolescents. knowledge of the diagnosis and treatment of this disease is largely based upon experience with adult patients. we recently reviewed our experience with blastomycosis to evaluate the difficulties in diagnosis and treatment of this disease in the pediatric population. ten patients with blastomycosis were identified during our review, and five had pulmonary disease alone. of these five patients, fou ... | 1996 | 8852969 |
| case report: blastomyces dermatitidis as a cause of middle lobe syndrome. | middle lobe syndrome is a clinical term used to describe right middle lobe atelectasis with or without bronchial compression. fungal disease has been implicated rarely as a cause of middle lobe syndrome. this is a patient with blastomyces dermatitidis infection who presented with right middle lobe syndrome. | 1996 | 8853069 |
| deep mycotic infections in cats. | a review of deep mycotic infections assessed incidence, signalment, clinical presentation, and outcome in 571 feline cases. pertinent findings included a predisposition in young, male cats for sporothrix schenckii and blastomyces dermatitidis. there was an increased incidence of feline leukemia virus infection in cases with histoplasmosis and of feline panleukopenia virus infection in cases with either aspergillosis or mucoralosis. few other predisposing conditions were identified. cryptococcosi ... | 1996 | 8875352 |
| community-acquired fungal pneumonia in children. | pediatric fungal pulmonary infections are being seen with increasing frequency. the dimorphic fungi histoplasma capsulatum. blastomyces dermatitidis, coccidioides immitis, and cryptococcus neoformans frequently cause infections that are asymptomatic. however, patients may suffer pneumonia and disseminated disease. diagnosis can be made definitively by isolation of the causative organism, but serology or skin testing is often necessary when this is not successful. severe or life threatening infec ... | 1996 | 8883177 |
| disseminated blastomycosis and acquired immunodeficiency syndrome: a case report and ultrastructural study. | a 42-year-old, african-american man presented with a 2-month history of weight loss and fever for 2 weeks. presumptive diagnoses of human immunodeficiency virus infection (hiv) and acquired immunodeficiency syndrome were made on the basis of a cd4 lymphocyte count of 23 lymphocytes/ml. chest x-ray revealed right paratracheal adenopathy and a miliary pattern. the etiology of the patient's pulmonary infection was not known, but tuberculosis was an important consideration. over 5 days, the pulmonar ... | 1996 | 8883326 |
| ajellomyces crescens sp. nov., taxonomy of emmonsia spp., and relatedness with blastomyces dermatitidis (teleomorph ajellomyces dermatitidis). | adiaspiromycosis is known primarily as a pulmonary infection of small burrowing mammals and rarely of humans, in which the tissue spore form consists of a large, globose, thick-walled, non-proliferating structure called an adiaspore. the causative agents have been placed in emmonsia or chrysosporium and treated as either two species or varieties. emmonsia parva (= chrysosporium parvum var. parvum) has been distinguished from e. crescens (= c parvum var. crescens) by differences in maximum growth ... | 1996 | 8912163 |
| chronic localized osteomyelitis caused by atypical infection with blastomyces dermatitidis in a dog. | a 4-year-old male golden retriever was evaluated because of chronic non-weight-bearing lameness of the right hind limb associated with penetrating tarsal wounds. arthritis of the tarsal joint and osteomyelitis of the talus were initially evident. tarsal arthrodesis was performed 7 months after initial injury, but the lameness persisted. ten months later, blastomycosis was diagnosed on the basis of results of histologic examination of bone biopsy specimens and serologic tests. no other site of in ... | 1996 | 8944801 |