Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| skin tuberculosis with atypical mycobacteria 8 years after combined pancreas-kidney transplantation. | we report on a mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. this is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. a genetic probe categorization revealed an infection with m. marinum. skin tuberculosis caused by m. marinum is an uncommon complication in kidney or pancreas-kidney transplant recipients, hence the diagnos ... | 2002 | 12381960 |
| strain variation in mycobacterium marinum fish isolates. | a molecular characterization of two mycobacterium marinum genes, 16s rrna and hsp65, was carried out with a total of 21 isolates from various species of fish from both marine and freshwater environments of israel, europe, and the far east. the nucleotide sequences of both genes revealed that all m. marinum isolates from fish in israel belonged to two different strains, one infecting marine (cultured and wild) fish and the other infecting freshwater (cultured) fish. a restriction enzyme map based ... | 2002 | 12406715 |
| tuberculin skin testing and in vitro t cell responses to esat-6 and culture filtrate protein 10 after infection with mycobacterium marinum or m. kansasii. | t cell responses to esat-6 and culture filtrate protein 10 (cfp-10), antigens expressed by mycobacterium tuberculosis but not by m. bovis bacille calmette-guérin (bcg), were found to discriminate reliably between infection with m. tuberculosis and bcg vaccination. because the esat-6 and cfp-10 genes occur in m. kansasii and m. marinum, t cell responses to esat-6 and cfp-10 were investigated in patients infected with m. kansasii or m. marinum, persons intensively exposed to environmental mycobact ... | 2002 | 12447766 |
| disseminated cutaneous mycobacterium marinum infection in a patient with non-hodgkin's lymphoma. | a 60-year-old woman with non-hodgkin's lymphoma was admitted to the hospital because of extensive subcutaneous abscesses developing on all limbs. the patient had an aquarium and kept tropical fish as pets. after repeated investigations, the diagnosis of mycobacterium marinum was established from skin biopsy by pcr and culture. long-term therapy with several drugs regimens had only a limited efficacy and was accompanied by severe adverse reactions. this report highlights the therapeutic problems ... | 2002 | 12478331 |
| real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. | infection of vertebrate hosts with pathogenic mycobacteria, the agents of tuberculosis, produces granulomas, highly organized structures containing differentiated macrophages and lymphocytes, that sequester the pathogen. adult zebrafish are naturally susceptible to tuberculosis caused by mycobacterium marinum. here, we exploit the optical transparency of zebrafish embryos to image the events of m. marinum infection in vivo. despite the fact that the embryos do not yet have lymphocytes, infection ... | 2002 | 12479816 |
| mycobacterium lacus sp. nov., a novel slowly growing, non-chromogenic clinical isolate. | a strain of a novel non-chromogenic mycobacterium was isolated from synovial tissue from a 68-year-old female with bursitis of her right elbow. the slowly growing strain had a unique pcr-restriction enzyme analysis (pra) profile of the hsp65 gene and 16s rrna gene sequence in comparison with other mycobacterium species. the most closely related species, as determined by 16s rrna gene sequence analysis, are mycobacterium malmoense, mycobacterium marinum, mycobacterium ulcerans and members of the ... | 2002 | 12508880 |
| mycobacterial infection in farmed turbot scophthalmus maximus. | mycobacteriosis (piscine tuberculosis) has been reported to affect a wide range of freshwater and marine fish species; however, this is the first report describing mycobacterial infections in turbot scophthalmus maximus. high numbers of granulomas were initially observed in the organs of moribund farmed turbot. bacteriological analysis of organs with granulomas led to the isolation of mycobacterium marinum. further analysis, to determine the prevalence of the infection in the farm and to identif ... | 2002 | 12517009 |
| [mycobacterium marinum infection]. | 2002 | 12522903 | |
| efficacy of oral minocycline and hyperthermic treatment in a case of atypical mycobacterial skin infection by mycobacterium marinum. | we report a case of atypical mycobacterial dermal infection caused by m. marinum, which was effectively treated with oral administration of minocycline and local hyperthermic treatment using chemical pocket warmers. a daily oral dose of 200 mg of minocycline was given, and local hyperthermic treatment was applied every evening for 5-6 hours with a disposable chemical pocket warmer. after 2.5 months of therapy, the lesion healed completely with scar formation. at 24 months after the completion of ... | 2002 | 12532049 |
| nostril infection due to mycobacterium marinum in an immunocompetent host. | mycobacterium marinum infection developed in the nostril of an immunocompetent host whose only risk factors were infrequent swimming and cleaning of a small fish bowl on a single occasion. the lesion relapsed after 2 surgical excisions but resolved slowly with a 9-month course of trimethoprim/sulfa therapy. | 2002 | 12587630 |
| pulmonary mycobacteriosis caused by mycobacterium haemophilum and m. marinum in a royal python. | an adult female royal python was referred with an 18-month history of chronic respiratory tract disease. anemia and moderate leukocytosis with heterophilia and monocytosis were detected and interpreted as evidence of a chronic inflammatory condition. evaluation of lateral and dorsoventral radiographic views revealed multiple soft-tissue opacities within the cranial lung fields. endoscopic evaluation revealed that the normal reticulated pattern on the surface of the lung had been largely replaced ... | 2002 | 12051506 |
| characterization of an unusual mycobacterium: a possible missing link between mycobacterium marinum and mycobacterium ulcerans. | in an attempt to characterize an unusual mycobacterial isolate from a 44-year-old patient living in france, we applied phenotypic characterizations and various previously described molecular methods for the taxonomic classification of mycobacteria. the results of the investigations were compared to those obtained in a previous study with a set of temporally and geographically diverse mycobacterium ulcerans (n = 29) and mycobacterium marinum (n = 29) isolates (k. chemlal, g. huys, p.-a. fonteyne, ... | 2002 | 12089250 |
| diverse bacteria are pathogens of caenorhabditis elegans. | practically and ethically attractive as model systems, invertebrate organisms are increasingly recognized as relevant for the study of bacterial pathogenesis. we show here that the nematode caenorhabditis elegans is susceptible to a surprisingly broad range of bacteria and may constitute a useful model for the study of both pathogens and symbionts. | 2002 | 12117988 |
| sixty-three cases of mycobacterium marinum infection: clinical features, treatment, and antibiotic susceptibility of causative isolates. | mycobacterium marinum is a nontuberculous mycobacterium responsible for skin infections. although cases have been seldom reported, no series of m marinum infection has been recently reported and the treatment is not standardized. | 2002 | 12153378 |
| strain variation in mediterranean and red sea mycobacterium marinum isolates. | four different pcr fingerprinting techniques were tested to distinguish possible strain variations in fourteen mycobacterium marinum isolates, thirteen from mediterranean and red sea fishes and one from a patient in sardinia, italy. pcr ribotyping and eric (enterobacterial repetitive consensus sequences)-pcr were found to be non-discriminative, whereas is (insertion sequences)-pcr and gtg (gtg sequences repeats)-pcr could distinguish the clinical isolate from the piscine isolates, two italian pi ... | 2002 | 12173779 |
| persistent ulcers on the hand of an aquarium owner. | we present a patient with skin ulcers that did not respond to a 3-week course of treatment with amoxicillin-clavulanic acid. as the patient maintained a fish aquarium, mycobacterial infection was suspected. indeed, reassessment of histopathology revealed acid-fast bacilli, and mycobacterial cultures at 30 degrees c grew mycobacterium marinum. eventually, surgical reconstruction of the tendons was needed. | 2002 | 12238586 |
| [pulmonary mycobacterioses--frequency of occurrence, clinical spectrum and predisposing factors]. | various types of non-tuberculous mycobacteria can be the aetiologic factors of chronic lung infections especially in patients with underlying chronic lung diseases. the aim of this study is to present the cases of pulmonary mycobacterioses observed in institute of tuberculosis and lung diseases in the years 1995-2001. there were 23 patients, 12 men and 11 women in the age between 35-77 years, mean 56 years. 16 out of 23 patients had underlying respiratory problems, mainly healed tuberculosis (7) ... | 2002 | 12884564 |
| mycobacterium marinum tenosynovitis in a patient on etanercept therapy for rheumatoid arthritis. | opportunistic infections are a theoretical concern with the use of tumor necrosis factor antagonists, as these agents can impair host immunity. a 61-year-old man with rheumatoid arthritis being treated with only etanercept (soluble tumor necrosis factor receptor) and in remission from the rheumatoid arthritis presented with dorsal tenosynovitis of his right wrist. the synovitis was not improved by a local corticosteroid injection. surgical exploration showed granulomatous inflammation, and cultu ... | 2002 | 17041383 |
| atypical presentation of mycobacteriosis in a collection of frogfish (antennarius striatus). | severe systemic mycobacteriosis without typical granuloma formation was diagnosed in a group of six mature, captive, striated frogfish antennarius striatus approximately 5 mo after fish originating from brazil were purchased by mote marine laboratory aquarium. beginning 1 mo after spawning, over a period of 9 mo, individuals began to show a variety of signs including egg retention, ocular opacity, poor buoyancy control, ascites with coelomic distension, skin lesions, and anorexia. two fish died, ... | 2003 | 15077718 |
| mycobacteriosis in two captive florida manatees (trichechus manatus latirostris). | two male florida manatees (trichechus manatus latirostris) died at the marine aquarium in inagi city, tokyo, japan. acid-fast bacteria were demonstrated in tuberculoid nodules in the lungs from both manatees. mycobacterium marinum and m. fortuitum were isolated from one manatee; m. marinum and m. kansasii were cultured from the second animal. this report confirms the pathogenicity and potentially fatal outcome of mycobacterial infection in manatees. in addition, the pathologic response to infect ... | 2003 | 12885137 |
| requirement for kasb in mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. | mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. the unusually low permeability of its cell wall contributes to the ability of m. tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. mycobacterium marinum is an established model for discovering genes involved in mycobacterial infection. mycobacterium marinum mutants with transposon insertions in the beta-ketoacyl-acyl carrier protein synthas ... | 2003 | 12950920 |
| zebrafish-mycobacterium marinum model for mycobacterial pathogenesis. | we report here the development of a pathogenesis model utilizing mycobacterium marinum infection of zebrafish (danio rerio) for the study of mycobacterial disease. the zebrafish model mimics certain aspects of human tuberculosis, such as the formation of granuloma-like lesions and the ability to establish either an acute or a chronic infection based upon inoculum. this model allows the genetics of mycobacterial disease to be studied in both pathogen and host. | 2003 | 12951238 |
| mycobacterium marinum infection in connecticut: report of four cases. | mycobacterium marinum is emerging as an important human pathogen in the united states. we report four cases incidentally diagnosed from culture of biopsy specimens of wrist lesions at a connecticut inner city hospital between 1996 and 1999. there was no clear association with aquatic exposure and only one patient recalled prior trauma. all were successfully treated with ethambutol and rifampicin. the current literature on the epidemiology, clinical characteristics and management of mycobacterium ... | 2003 | 12956043 |
| transforming growth factor-beta response to mycobacterial infection in striped bass morone saxatilis and hybrid tilapia oreochromis spp. | striped bass (morone saxatilis) and hybrid tilapia (oreochromis spp.) were experimentally infected with mycobacterium marinum. splenic mononuclear cell transforming growth factor-beta (tgf-beta) mrna was measured by reverse transcription quantitative-competitive pcr (rt-qcpcr). in histologic sections of liver and anterior kidney, the area of each section that was occupied by granulomas and the total area of each section were measured by computer-assisted image analysis and compared as a proporti ... | 2003 | 12963276 |
| a recombinant vaccine expressing a mammalian mycobacterium sp. antigen is immunostimulatory but not protective in striped bass. | a recombinant vaccine was constructed for piscine mycobacteriosis utilizing a brucella abortus strain rb51 vector expressing a mammalian mycobacterium sp. 85a antigen. juvenile striped bass were inoculated with the resulting construct at doses equivalent to 10(6), 10(7), 10(8), 10(9), and 10(10) colony-forming units/fish. blood and tissue samples from these fish demonstrated significant specific humoral and cell-mediated immune responses towards the 85a antigen in a dose-dependent manner. howeve ... | 2003 | 12969635 |
| interleukin-8 is differentially expressed by human-derived monocytic cell line u937 infected with mycobacterium tuberculosis h37rv and mycobacterium marinum. | although mycobacterium marinum is closely related to mycobacterium tuberculosis h37rv genomically, the clinical outcome in humans is quite different for m. marinum and m. tuberculosis infections. we investigated possible factors in the host macrophages for determining differential pathological responses to m. tuberculosis and m. marinum using an in vitro model of mycobacterial infection. using suppression-subtractive hybridization, we identified 12 differentially expressed genes in the human mon ... | 2003 | 14500465 |
| the secret lives of the pathogenic mycobacteria. | pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy, are responsible for considerable morbidity and mortality worldwide. a hallmark of these pathogens is their tendency to establish chronic infections that produce similar pathologies in a variety of hosts. during infection, mycobacteria reside in macrophages and induce the formation of granulomas, organized immune complexes of differentiated macrophages, lymphocytes, and other cells. this review summarizes our und ... | 2003 | 14527294 |
| emerging pathologies in aquaculture: effects on production and food safety. | infectious diseases represent a limiting factor for the further development of italian aquaculture. the recent introduction and spreading of new pathogens, along with the global climatic change, has contributed to a considerable decrease in trout production. emerging pathologies in rainbow trout culture include viral diseases, e.g. infectious haematopoietic necrosis (ihn), bacterial diseases, such as lactococcosis and visceral flavobacteriosis, and parasitical diseases, e.g. proliferative kidney ... | 2003 | 14535454 |
| mycobacterium marinum: a case of skin granuloma complicated by tenosynovitis of the extensors. | the authors report the case of a male patient who owned a tropical aquarium and who developed a m. marinum skin infection of the wrist. the clinical findings and microbiological features of the case are described, as are the difficulty in providing a prompt diagnosis, and the need for surgical treatment and the use of antibiotics to treat the infection. | 2003 | 14584321 |
| mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. | mycobacteria are responsible for a number of human and animal diseases and are classical intracellular pathogens, living inside macrophages rather than as free-living organisms during infection. numerous intracellular pathogens, including listeria monocytogenes, shigella flexneri, and rickettsia rickettsii, exploit the host cytoskeleton by using actin-based motility for cell to cell spread during infection. here we show that mycobacterium marinum, a natural pathogen of fish and frogs and an occa ... | 2003 | 14597736 |
| interferon-gamma and skin test responses of schoolchildren in southeast england to purified protein derivatives from mycobacterium tuberculosis and other species of mycobacteria. | the immune responses of schoolchildren in southeast england to mycobacterium tuberculosis and other species of mycobacteria were studied prior to vaccination with bacille calmette-guérin (bcg). data are presented for tuberculin (heaf) skin test and interferon-gamma (ifn-gamma) responses to m. tuberculosis purified protein derivative (ppd), and ifn-gamma responses to ppds from eight other environmental mycobacteria, measured in 424 schoolchildren (13-15 years of age). responses to m. tuberculosis ... | 2003 | 14616789 |
| subtractive hybridization reveals a type i polyketide synthase locus specific to mycobacterium ulcerans. | mycobacterium ulcerans causes buruli ulcer, the third most prevalent mycobacterial infection of immunocompetent humans after tuberculosis and leprosy. recent work has shown that the production by m. ulcerans of mycolactone, a novel polyketide, may partly explain the pathogenesis of buruli ulcer. to search for the genetic basis of virulence in m. ulcerans, we took advantage of the close genetic relationship between m. ulcerans and mycobacterium marinum by performing genomic suppressive subtractiv ... | 2003 | 14617651 |
| lactococcus garvieae in wild red sea wrasse coris aygula (labridae). | lactococcus garvieae infection in wild wrasse coris aygula is reported, and the serological and molecular characteristics of the isolate are described. this is the first evidence of the presence of this pathogen in the red sea, and it follows the recent diagnosis of mycobacterium marinum and streptococcus iniae in wild fish from the same region. whether all 3 pathogens are strains endemic to the red sea, or recent introductions into the region, remains to be determined, but their appearance over ... | 2003 | 14667040 |
| invasive mycobacterium marinum infections. | 2003 | 14725262 | |
| transposition of tn5367 in mycobacterium marinum, using a conditionally recombinant mycobacteriophage. | mycobacterium marinum is a close relative of the obligate human pathogen mycobacterium tuberculosis. as with m. tuberculosis, m. marinum causes intracellular infection of poikilothermic vertebrates and skin infection in humans. it is considered a valid model organism for the study of intracellular pathogenesis of mycobacteria. low transformation efficiencies for this species have precluded approaches using mutant libraries in pathogenesis studies. we have adapted the conditionally replicating my ... | 2003 | 12591896 |
| [treatment resistant nodules in the arm of an officer]. | 2003 | 12607475 | |
| ill from eel? | 2003 | 12614734 | |
| mycobacterium marinum osteomyelitis. | 2003 | 12650330 | |
| mycobacterium marinum infection simulating interstitial granuloma annulare: a report of two cases. | we report two cases of mycobacterium marinum infection that histologically simulated interstitial granuloma annulare (ga). in one case, an infectious etiology was not suspected in histologic sections, but a tissue culture performed during the patient's clinic visit identified m. marinum, and a subsequent fite stain revealed mycobacteria. interstitial granulomatous dermatitis is a rare presentation for cutaneous nontuberculous mycobacteria and has yet to be attributed specifically to m. marinum. ... | 2003 | 12652197 |
| in vitro activity of linezolid against slowly growing nontuberculous mycobacteria. | mics of linezolid in broth microdilutions were tested against 341 slowly growing nontuberculous mycobacteria (ntm) belonging to 15 species. the proposed linezolid susceptibility mics for all mycobacterium marinum, mycobacterium szulgai, mycobacterium kansasii, mycobacterium malmoense, and mycobacterium xenopi isolates and for 90% of mycobacterium gordonae and mycobacterium triplex isolates were </=8 micro g/ml. linezolid has excellent therapeutic potential against most species of ntm. | 2003 | 12709349 |
| mycobacterium shottsii sp. nov., a slowly growing species isolated from chesapeake bay striped bass (morone saxatilis). | slowly growing, non-pigmented mycobacteria were isolated from striped bass (morone saxatilis) during an epizootic of mycobacteriosis in the chesapeake bay. growth characteristics, acid-fastness and results of 16s rrna gene sequencing were consistent with those of the genus mycobacterium. a unique profile of biochemical reactions was observed among the 21 isolates. a single cluster of eight peaks identified by analysis of mycolic acids (hplc) resembled those of reference patterns but differed in ... | 2003 | 12710607 |
| experimental mycobacteriosis in striped bass morone saxatilis. | striped bass morone saxatilis were infected intraperitoneally with approximately 10(5) mycobacterium marinum, m. shottsii sp. nov., or m. gordonae. infected fish were maintained in a flow-through freshwater system at 18 to 21 degrees c, and were examined histologically and bacteriologically at 2, 4, 6, 8, 17, 26, 36 and 45 wk post-infection (p.i.). m. marinum caused acute peritonitis, followed by extensive granuloma development in the mesenteries, spleen and anterior kidney. granulomas in these ... | 2003 | 12747636 |
| drosophila melanogaster is a genetically tractable model host for mycobacterium marinum. | mycobacterium marinum is a pathogenic mycobacterial species that is closely related to mycobacterium tuberculosis and causes tuberculosis-like disease in fish and frogs. we infected the fruit fly drosophila melanogaster with m. marinum. this bacterium caused a lethal infection in the fly, with a 50% lethal dose (ld(50)) of 5 cfu. death was accompanied by widespread tissue damage. m. marinum initially proliferated inside the phagocytes of the fly; later in infection, bacteria were found both insi ... | 2003 | 12761139 |
| intracellular replication of mycobacterium marinum within dictyostelium discoideum: efficient replication in the absence of host coronin. | mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial species. we demonstrate here that m. marinum grows within dictyostelium discoideum cells, allowing the genetic analysis of host factors that may modulate the replication of mycobacterial species. intracellular growth of m. marinum was shown to mimic the properties pr ... | 2003 | 12761143 |
| [bothersome nodules on the fingers of a musician]. | 2003 | 12762204 | |
| [cutaneous nodules to an aquarist]. | 2003 | 12763180 | |
| mycobacterium marinum infections of the distal upper extremities: clinical course and imaging findings in two cases with delayed diagnosis. | mycobacterium marinum infections cause tenosynovitis of the distal upper extremities and develop as a consequence of skin abrasions acquired in contaminated water. we report on two patients whose mr imaging studies showed tenosynovitis of the distal upper extremity secondary to m. marinum. in one patient sequential mr imaging showed development of bony erosions. appropriate treatment was delayed in both patients because the diagnosis was not considered. we report on and discuss the clinical cour ... | 2003 | 12774175 |
| decolorization of malachite green and crystal violet by waterborne pathogenic mycobacteria. | mycobacterium avium, mycobacterium intracellulare, mycobacterium scrofulaceum, mycobacterium marinum, and mycobacterium chelonae tolerate high concentrations of the dyes malachite green and crystal violet. cells of strains of those species decolorized (reduced) both malachite green and crystal violet. because decolorized malachite green lacked antimicrobial activity, the resistance of these mycobacteria could be due, in part, to their ability to decolorize the dyes. small amounts of malachite gr ... | 2003 | 12821489 |
| [tropical fish salesmen's knowledge and behaviour concerning "fish tank granuloma"]. | mycobacterium marinum is responsible for "fish tank granuloma", a chronic and sometimes disabling skin infection, which in france would be the most frequent "atypical" cutaneous mycobacteriosis. tropical fish salesmen are concerned about this disease because they might sell contaminated fish and be infected themselves. a review of the literature indicated that one quarter of the patients were aquarium workers. this original study tested the salesmen's knowledge and behaviour regarding "fish tank ... | 2003 | 12843853 |
| [wrong diagnosis in the case of skin nodules in a musician?]. | 2003 | 12868364 | |
| [granulomatous skin disease after an exotic injury]. | piranhas are feared freshwater fishes commonly found in the waters of southern venezuela to the north of argentina. at present this species is a favourite domesticated article of our aquarists. the authors describe the histopathologic picture of a cutaneous lesion of the right hand thumb of a 60-year old piranha keeper who was bitten by this predatory fish. a firm node with increasing soreness gradually developed in the area of the lesion, and after 7 months the symptoms of the carpal tunnel syn ... | 2003 | 12874906 |
| a prolonged case of mycobacterium marinum flexor tenosynovitis: radiographic and histological correlation, and review of the literature. | we report on a 30-year-old man with prolonged mycobacterium marinum flexor tenosynovitis. due to low clinical suspicion, diagnosis was not made until 8 years after initial presentation. the history and magnetic resonance and tissue examination findings are consistent with mycobacterial tenosynovitis. these findings are presented, together with a review of the literature. | 2003 | 12879295 |
| fish tank exposure and cutaneous infections due to mycobacterium marinum: tuberculin skin testing, treatment, and prevention. | in the present study, 8 patients with soft tissue infection due to mycobacterium marinum are described, and contemporary data on treatment are reviewed. six patients had positive cultures, all patients had cutaneous exposure to fish tanks, 7 had sporotrichoid lesions, and 2 had deep infection. all 7 tested patients had tuberculin skin test reactions > or =10 mm. six patients with disease limited to the skin were successfully treated with 2-drug combination therapy, including clarithromycin, etha ... | 2003 | 12884164 |
| transposon mutagenesis of mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. | pathogenic mycobacteria survive and replicate within host macrophages, but the molecular mechanisms involved in this necessary step in the pathogenesis of infection are not completely understood. mycobacterium marinum has recently been used as a model for aspects of the pathogenesis of tuberculosis because of its close genetic relationship to mycobacterium tuberculosis and because of similarities in the pathology and course of infection caused by this organism in its natural hosts, fish and frog ... | 2003 | 12540574 |
| biofilm formation and biocide susceptibility testing of mycobacterium fortuitum and mycobacterium marinum. | the ability of non-tuberculous mycobacteria to form biofilms may allow for their increased resistance to currently used biocides in medical and industrial settings. this study examines the biofilm growth of mycobacterium fortuitum and mycobacterium marinum, using the mbec trade mark assay system, and compares the susceptibility of planktonic and biofilm cells to commercially available biocides. with scanning electron microscopy, both m. fortuitum and m. marinum form biofilms that are morphologic ... | 2003 | 12432460 |
| [cutaneous infection with mycobacterium marinum. successful therapy with rifampicin and clarithromycin]. | we report on two male patients with cutaneous mycobacterium marinum infection. after the diagnosis was established by culture, therapy with rifampicin and clarithromycin over a period of three months led to remarkable improvement. | 2004 | 14749869 |
| macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the esat-6 gene family and new phylogenetic markers for the mycobacterium tuberculosis complex. | to better understand the biology and the virulence determinants of the two major mycobacterial human pathogens mycobacterium tuberculosis and mycobacterium leprae, their genome sequences have been determined recently. in silico comparisons revealed that among the 1439 genes common to both m. tuberculosis and m. leprae, 219 genes code for proteins that show no similarity with proteins from other organisms. therefore, the latter 'core' genes could be specific for mycobacteria or even for the intra ... | 2004 | 14766927 |
| pimf, a mannosyltransferase of mycobacteria, is involved in the biosynthesis of phosphatidylinositol mannosides and lipoarabinomannan. | phosphatidylinositol mannosides (pims) and their related molecules lipomannan (lm) and lipoarabinomannan (lam) are important components of the mycobacterial cell wall. these molecules mediate host-pathogen interactions and exhibit immunomodulatory activities. the biosynthesis of these lipoglycans is not fully understood. in this study, we have identified a mycobacterial gene (rv1500) that is involved in the synthesis of pims. we have named this gene pimf. transposon mutagenesis of pimf of mycoba ... | 2004 | 14960574 |
| mycobacterium-inducible nramp in striped bass (morone saxatilis). | in mammals, the natural resistance-associated macrophage protein 1 gene, nramp1, plays a major role in resistance to mycobacterial infections. chesapeake bay striped bass (morone saxatilis) is currently experiencing an epizootic of mycobacteriosis that threatens the health of this ecologically and economically important species. in the present study, we characterized an nramp gene in this species and obtained evidence that there is induction following mycobacterium exposure. the striped bass nra ... | 2004 | 14977970 |
| images in clinical medicine. mycobacterium marinum. | 2004 | 14985501 | |
| identification of mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis. | mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related mycobacterium species (outside the m. tuberculosis complex) to m. tuberculosis, the etiologic agent of human tuberculosis. signature-tagged mutagenesis was used to identify genes of m. marinum required for in vivo survival in a goldfish model of mycobacterial pathogenesis. screening the first 1008 m. marinum mutants led to the identification of 40 putative virulence mutants. dna sequence analysis of ... | 2004 | 15019737 |
| [sporotrichoid atypical mycobacterial infections. antibiotic monotherapy]. | sporotrichoid forms of atypical mycobacterial infections usually do not show a tendency to spontaneous healing. the therapy of choice in such cases is systemic antibiotics. we report three cases of sporotrichoid atypical mycobacterial infections of the skin which healed completely under long-term monotherapy with modern antibiotics (levofloxacin, clarithromycin, minocycline). we recommend confirming the diagnosis by means of culture, followed by monotherapy with low side-effect antibiotics, base ... | 2004 | 15029437 |
| piscine mycobacteriosis: a literature review covering the agent and the disease it causes in fish and humans. | mycobacterium marinum, m. fortuitum and m. chelonae are the etiological agents of fish mycobacteriosis. fish mycobacteriosis is a disseminated infection reported in more than 150 fish species and is usually accompanied by emaciation and death over a period of months to years. granulomas are formed both externally and scattered throughout the internal organs. treatment is in most cases unsatisfactory and the overall recommendation is to destroy the diseased stock, particularly since these pathoge ... | 2004 | 15066718 |
| expression analysis of the toll-like receptor and tir domain adaptor families of zebrafish. | the zebrafish genomic sequence database was analysed for the presence of genes encoding members of the toll-like receptors (tlr) and interleukin receptors (il-r) and associated adaptor proteins containing a tir domain. the resulting predictions show the presence of one or more counterparts for the human tlr1, tlr2, tlr3, tlr4, tlr5, tlr7, tlr8, tlr9, il-1r and il-18r genes and one copy of the adaptor genes myd88, mal, trif and sarm. in contrast to data for the pufferfish fugu rubripes, zebrafish ... | 2004 | 14687934 |
| mycobacterium marinum infection. | a 49-year-old man presented with nodules on his right hand after a history of mycobacterium marinum infection recently treated with rifampin and clarithromycin. the patient has an aquarium with betta fish (siamese fighting fish). | 2004 | 15748591 |
| [skin infection caused by mycobacterium marinum]. | mycobacterium (m.) marinum is a human opportunistic pathogen, capable of causing skin infections and possibly also affecting deeper tissues. the authors describe a case of skin infection caused by m. marinum in a female patient with an appropriate case history. they emphasize the need of close cooperation of the clinician with a microbiologist when establishing the diagnosis. | 2004 | 15100981 |
| buruni ulcer disease. | 2004 | 15114764 | |
| acquisition of hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. | pathogenic mycobacteria survive within macrophages by precluding the fusion of phagosomes with late endosomes or lysosomes. because the molecular determinants of normal phagolysosome formation are poorly understood, the sites targeted by mycobacteria remain unidentified. we found that hrs, an adaptor molecule involved in protein sorting, associates with phagosomes prior to their fusion with late endosomes or lysosomes. recruitment of hrs required the interaction of its fyve domain with phagosoma ... | 2004 | 15121875 |
| recurrent mycobacterium marinum tenosynovitis of the wrist mimicking extraarticular synovial chondromatosis on mr images. | tenosynovitis caused by atypical mycobacterial infections may produce rice bodies within affected tendon sheaths. we report a case of recurrent m. marinum infection involving the flexor tendons within the carpal tunnel in which the rice bodies were mistaken for synovial chondromatosis on mr images. | 2004 | 15127246 |
| the pathogen mycobacterium marinum, a faster growing close relative of mycobacterium tuberculosis, has a single rrna operon per genome. | although mycobacterium marinum and mycobacterium tuberculosis are very closely related they differ significantly in their growth rates. the type strain of m. marinum and one clinical isolate were investigated and, like m. tuberculosis, were found to have a single rrna (rrn) operon per genome located downstream from mura gene and controlled by two promoters. no sequence differences were found that account for the difference in the growth rates of the two species. we infer that m. tuberculosis has ... | 2004 | 15183875 |
| phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. | we studied the anti-microbial effects of phenoxazines produced by the reaction of o-aminophenol or its derivatives with bovine hemoglobin, on seven species of mycobacteria such as mycobacterium tuberculosis, mycobacterium marinum, mycobacterium intracellulare, mycobacterium scrofulaceum, mycobacterium fortuitum, mycobacterium kansasii and mycobacterium smegmatis and some bacteria such as escherichia coli, pseudomonas aeruginosa, salmonella enterica serovar typhimurium, staphylococcus aureus, lis ... | 2004 | 15185971 |
| mycobacterium marinum: mr imaging and clinical course of a rare soft tissue infection. | mycobacterium marinum is a rare cause of soft tissue infections. the imposing mr appearance of the soft tissue involvement is in contrast to the chronic painless clinical manifestation. | 2004 | 15205928 |
| superinfecting mycobacteria home to established tuberculous granulomas. | a central paradox of tuberculosis immunity is that reinfection and bacterial persistence occur despite vigorous host immune responses concentrated in granulomas, which are organized structures that form in response to infection. prevailing models attribute reinfection and persistence to bacterial avoidance of host immunity via establishment of infection outside primary granulomas. alternatively, persistence is attributed to a gradual bacterial adaptation to evolving host immune responses. we sho ... | 2004 | 15220915 |
| new models for the study of mycobacterium-host interactions. | the outcome of mycobacterium infection is determined by a series of complex interactions between the bacteria and host immunity. traditionally, mammalian models and cultured cells have been used to study these interactions. recently, ameba (dictyostelium), fruit flies (drosophila) and zebrafish, amenable to forward genetic screens, have been developed as models for mycobacterial pathogenesis. infection of these hosts with mycobacteria has allowed the dissection of intracellular trafficking pathw ... | 2004 | 15245746 |
| mycobacterium marinum causing tenosynovitis. 'fish tank finger'. | mycobacterium marinum is an unusual atypical mycobacterium with low pathogenicity for humans in comparison with mycobacterium tuberculosis. among the non-tuberculous mycobacterial pathogens, mycobacterium marinum is the most common pathogen to cause skin infections. mycobacterium marinum infection causes chronic cutaneous lesions and in some cases deeper infections such as tenosynovitis, septic arthritis and rarely osteomyelitis. we report the case of a male patient presenting with tenosynovitis ... | 2004 | 15287410 |
| characterization of a trinucleotide repeat sequence (cgg)5 and potential use in restriction fragment length polymorphism typing of mycobacterium tuberculosis. | the genomes of 28 bacterial strains, including mycobacterial species mycobacterium tuberculosis and mycobacterium bovis, were analyzed for the presence of a special class of microsatellite, that of trinucleotide repeat sequences (trs). results of a search of all 10 possible trs motifs (i.e., cct, cgg, ctg, gaa, gat, gta, gtc, gtg, gtt, and tat) with five or more repeating units showed that (cgg)(5) was highly represented within the genomic dna of m. tuberculosis and m. bovis. most of the (cgg)(5 ... | 2004 | 15297495 |
| images in clinical medicine. tenosynovitis due to mycobacterium marinum. | 2004 | 15329429 | |
| a mycobacterial virulence gene cluster extending rd1 is required for cytolysis, bacterial spreading and esat-6 secretion. | initiation and maintenance of infection by mycobacteria in susceptible hosts are not well understood. a screen of mycobacterium marinum transposon mutant library led to isolation of eight mutants that failed to cause haemolysis, all of which had transposon insertions in genes homologous to a region between rv3866 and rv3881c in mycobacterium tuberculosis, which encompasses rd1 (rv3871-rv3879c), a known virulence gene cluster. the m. marinum mutants showed decreased virulence in vivo and failed t ... | 2004 | 15341647 |
| [detection and identification of mycobacteria with polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) from patients with mycobacterial skin infections]. | to establish a rapid approach to the detection and identification of mycobacteria from lesions of patients with suspected mycobacterial infections. | 2004 | 15489922 |
| mycobacterium marinum strains can be divided into two distinct types based on genetic diversity and virulence. | mycobacterium marinum causes a systemic tuberculosis-like disease in a large number of poikilothermic animals and is used as a model for mycobacterial pathogenesis. in the present study, we infected zebra fish (danio rerio) with different strains of m. marinum to determine the variation in pathogenicity. depending on the m. marinum isolate, the fish developed an acute or chronic disease. acute disease was characterized by uncontrolled growth of the pathogen and death of all animals within 16 day ... | 2004 | 15501758 |
| in vitro response of the striped bass natural resistance-associated macrophage protein, nramp, to lps and mycobacterium marinum exposure. | mycobacteriosis in chesapeake bay (usa) striped bass morone saxatilis is an ongoing disease problem with important economic implications for a large commercial and recreational fishery. additionally, striped bass serve as a reservoir of potential mycobacterial zoonoses. recently, we described a striped bass gene homolog of the natural resistance-associated macrophage protein family (msnramp), which is responsible for resistance to mycobacterial infections in mice. striped bass msnramp is strongl ... | 2004 | 15533797 |
| myths and misconceptions: not all that glitters under the watch is gold (nickel) dermatitis. | 2004 | 15538087 | |
| identification of two mycobacterium marinum loci that affect interactions with macrophages. | mycobacterium marinum is closely related to mycobacterium tuberculosis, the cause of tuberculosis in humans. m. marinum has become an important model system for the study of the molecular mechanisms involved in causing tuberculosis in humans. through molecular genetic analysis of the differences between pathogenic and nonpathogenic mycobacteria, we identified two loci that affect the ability of m. marinum to infect macrophages, designated mel(1) and mel(2). in silico analyses of the 11 putative ... | 2004 | 15557611 |
| mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. | mycobacterium marinum is being used increasingly as a model for understanding pathogenic mycobacteria. however, recently discovered differences between m. marinum and m. tuberculosis suggest that adaptation to specialized niches is reflected in unique strategies of pathogenesis. this review emphasizes the areas in which studying m. marinum has made contributions to the understanding of tuberculosis, as well as the potential for using characteristics unique to m. marinum for understanding general ... | 2004 | 15596129 |
| ultrastructure of mycobacterium marinum granuloma in striped bass morone saxatilis. | an emerging epizootic of mycobacteriosis currently threatens striped bass morone saxatilis populations in chesapeake bay, usa. several species of mycobacteria, including mycobacterium marinum, species resembling m. avium, m. gordonae, m. peregrinum, m. scrofulaceum and m. terrae, and the new species m. shottsii have been isolated from diseased and healthy bass. in this study, we describe the ultrastructure of developing m. marinum granulomas in experimentally infected bass over a period of 45 wk ... | 2004 | 15648839 |
| [rheumatoid nodules: to be or not to be - case report.] | a 49-year old man suffered a superficial injury on the dorsum of the right hand. subsequently, a wound developed which healed slowly despite several courses of oral antibiotics. gradually, nodular lesions developed on the hand. a biopsy of the nodules showed granulomatous inflammation which was considered to be consistent with rheumatoid nodules. local injections with corticosteroids were administered with only temporary relief. eigtheen months after the original injury a biopsy was performed an ... | 2004 | 16819055 |
| [persistent erythematous nodule on the back of the hand]. | 2005 | 15685440 | |
| actin-based motility of intracellular pathogens. | the actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of entering into non-phagocytic cells, the so-called 'invasive bacteria'. among them, a few also exploit the host actin cytoskeleton to move intra- and inter-cellularly. our knowledge of the basic mechanisms underlying actin-based motility has dramatically increased and the list of bacteria that are able to move in this way is also increasing including not only listeria, shigella and rickettsia species but also m ... | 2005 | 15694855 |
| mycobacterium marinum infections in fish and humans in israel. | israeli mycobacterium marinum isolates from humans and fish were compared by direct sequencing of the 16s rrna and hsp65 genes, restriction mapping, and amplified fragment length polymorphism analysis. significant molecular differences separated all clinical isolates from the piscine isolates, ruling out the local aquaculture industry as the source of human infections. | 2005 | 15695698 |
| genotyping mycobacterium ulcerans and mycobacterium marinum by using mycobacterial interspersed repetitive units. | a novel category of variable tandem repeats (vntr) called mycobacterial interspersed repetitive units (mirus) has been identified for mycobacterium ulcerans (n = 39), m. marinum (n = 27), and one related organism. fifteen miru loci were identified in the genome of m. marinum and were used to genotype m. ulcerans, m. marinum, and an m. marinum-like organism that is considered a possible missing link between m. marinum and m. ulcerans. seven miru loci were polymorphic, and locus-specific pcrs for ... | 2005 | 15716434 |
| common evolutionary origin for the unstable virulence plasmid pmum found in geographically diverse strains of mycobacterium ulcerans. | the 174-kb virulence plasmid pmum001 in mycobacterium ulcerans epidemic strain agy99 harbors three very large and homologous genes that encode giant polyketide synthases (pks) responsible for the synthesis of the lipid toxin mycolactone. deeper investigation of m. ulcerans agy99 resulted in identification of two types of spontaneous deletion variants of pmum001 within a population of cells that also contained the intact plasmid. these variants arose from recombination between two 8-kb sections o ... | 2005 | 15716437 |
| mycobacterium marinum infections of the upper extremity. | a significant number of patients infected with mycobacterium marinum have been treated at the curtis national hand center in baltimore, maryland. the purpose of this study was to review the authors' experience with m. marinum infections of the upper extremity. twenty-nine patients were identified and their charts were reviewed for all factors related to diagnosis and treatment. the most common presenting symptoms were swelling (n = 25) and pain (n = 14). only 69 percent of patients could correla ... | 2005 | 15731663 |
| pulmonary infection due to mycobacterium marinum in an immunocompetent patient. | 2005 | 15614719 | |
| immunogenic and protective effects of a dna vaccine for mycobacterium marinum in fish. | mycobacteriosis, caused by numerous mycobacterium spp., can be a devastating disease of both wild and cultured fishes. as no efficacious treatment exists, a vaccine against fish mycobacteriosis is essential for prevention and control of this disease. thus, a dna vaccine was constructed using the mycobacterium marinum ag85a gene that encodes one of the major secreted fibronectin-binding proteins of mycobacterium spp., which was isolated and then subcloned into a commercially available eukaryotic ... | 2005 | 15621306 |
| gouty flexor tenosynovitis of the hand mimicking atypical mycobacterial infection. | a 50-year-old japanese fish dealer presented with painful and swollen fingers. infectious flexor tenosynovitis with mycobacterium marinum was suspected. range of motion was restored after tenosynovectomy and after ofloxacin and clarithromycin were administered. two years after the operation, the patient presented again with acute inflammation in the same fingers. histopathological examination revealed gouty tenosynovitis. the preconception that mycobacterial infection occurs often in fish dealer ... | 2005 | 17029107 |
| laboratory maintenance of mycobacterium marinum. | m. marinum naturally infects fish and amphibians and causes diseases in these animals with pathological features similar to the human disease caused by m. tuberculosis. at the genetic and biochemical levels, m. marinum is closely related to m. tuberculosis. because of these and other properties of m. marinum (such as its fast growth rate and convenient laboratory handing on the benchtop), m. marinum has been increasingly used as a model for studying m. tuberculosis pathogenesis. the protocols in ... | 2005 | 18770549 |
| functional analysis and annotation of the virulence plasmid pmum001 from mycobacterium ulcerans. | the presence of a 174 kb plasmid called pmum001 in mycobacterium ulcerans, the first example of a mycobacterial plasmid encoding a virulence determinant, was recently reported. over half of pmum001 is devoted to six genes, three of which encode giant polyketide synthases (pks) that produce mycolactone, an unusual cytotoxic lipid produced by m. ulcerans. in this present study the remaining 75 non-pks-associated protein-coding sequences (cds) are analysed and it is shown that pmum001 is a low-copy ... | 2005 | 15758215 |
| a case of granulomatous skin lesions caused by mycobacterium marinum in the campania region. | the diagnosis of cutaneous mycobacterium marinum infection is frequently presumptive, as detection by conventional methods is difficult. we describe a patient with granulomatous skin lesions on the right dorsal hand and forearm. histological examinations were presumptive for mycobacterium lesions. we identified mycobacterium marinum directly in the patient's lesional skin biopsy combining polymerase chain reaction (pcr) amplification using mycobacterium genus-specific primers, and subsequent res ... | 2005 | 15782631 |
| simultaneous chronic cutaneous infection with mycobacterium marinum and nocardia asteroides. | 2005 | 15793529 | |
| [mycobacterium marinum nodular lymphangitis]. | 2005 | 15811287 |