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bacillus coagulans mtcc 5856 supplementation in the management of diarrhea predominant irritable bowel syndrome: a double blind randomized placebo controlled pilot clinical study.bacillus coagulans mtcc 5856 has been marketed as a dietary ingredient, but its efficacy in diarrhea predominant irritable bowel syndrome (ibs) condition has not been clinically elucidated till date. thus, a double blind placebo controlled multi-centered trial was planned to evaluate the safety and efficacy of b. coagulans mtcc 5856 in diarrhea predominant ibs patients.201626922379
effects of probiotic supplementation in different nutrient density diets on growth performance, nutrient digestibility, blood profiles, fecal microflora and noxious gas emission in weaning pig.probiotics can serve as alternatives to antibiotics to increase the performance of weaning pigs, and the intake of probiotics is affected by dietary nutrient density. the objective of this study was to evaluate the effects of a probiotic complex in different nutrient density diets on growth performance, digestibility, blood profiles, fecal microflora and noxious gas emission in weaning pigs.201727342952
metabolic engineering of escherichia coli k12 for homofermentative production of l-lactate from xylose.the efficient utilization of xylose is regarded as a technical barrier to the commercial production of bulk chemicals from biomass. due to the desirable mechanical properties of polylactic acid (pla) depending on the isomeric composition of lactate, biotechnological production of lactate with high optical pure has been increasingly focused in recent years. the main objective of this work was to construct an engineered escherichia coli for the optically pure l-lactate production from xylose. six ...201728840503
protective effects of synbiotic diets of bacillus coagulans, lactobacillus plantarum and inulin against acute cadmium toxicity in rats.cadmium is a heavy metal that causes oxidative stress and has toxic effects in humans. the aim of this study was to investigate the influence of two probiotics along with a prebiotic in preventing the toxic effects of cadmium in rats.201728583137
probiotic bacillus: fate during sausage processing and storage and influence of different culturing conditions on recovery of their spores.the current study was designed to assess the fate of probiotic strains of bacillus coagulans atcc 31284 and bacillus subtilis var. natto atcc 15245 (as spores) during processing and refrigerated storage of cooked sausage as well as the influence of culturing conditions on the recovery of spores. the highest recovery of b. coagulans atcc 31284 and b. subtilis var. natto atcc 15245 spores were obtained on trypticase soy agar (tsa) (15.22 and 15.12logcfu/ml, respectively) which was carried out unde ...201728395824
inactivated probiotic bacillus coagulans gbi-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro.the aim of this study was to document the immune activating and anti-inflammatory effects of inactivated probiotic bacillus coagulans gbi-30, 6086 (staimune™) cells on human immune cells in vitro.201728848360
rational design of bacillus coagulans nl01 l-arabinose isomerase and use of its f279i variant in d-tagatose production.d-tagatose is a prospective functional sweetener that can be produced by l-arabinose isomerase (ai) from d-galactose. to improve the activity of ai toward d-galactose, the ai of bacillus coagulans was rationally designed on the basis of molecular modeling and docking. after alanine scanning and site-saturation mutagenesis, variant f279i that exhibited improved activity toward d-galactose was obtained. the optimal temperature and ph of f279i were determined to be 50 °c and 8.0, respectively. this ...201728530095
lactic acid bacteria-specific induction of cd4(+)foxp3(+)t cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mtor signaling.the beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. in the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomy ...201728512288
bacillus coagulans gbi-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (tim-1).the aim of this study was to assess the potential of the probiotic bacillus coagulans gbi-30, 6086 [ganedenbc(30)] (bc30) to aid in protein digestion of alimentary plant proteins. to test this, three plant proteins, from pea, soy and rice, were digested in a validated in vitro model of the stomach and small intestine (tim-1) in the absence and in the presence of bc30. samples were taken from the tim-1 fractions that mimic uptake of amino acids by the host and analysed for α-amino nitrogen (aan) ...201728504581
the effects of bacillus coagulans-fermented and non-fermented ginkgo biloba on abdominal fat deposition and meat quality of peking duck. 201728444385
production of high concentration of l-lactic acid from oil palm empty fruit bunch by thermophilic bacillus coagulans ji12.thermophilic bacillus coagulans ji12 was used to ferment hemicellulose hydrolysate obtained by acid hydrolysis of oil palm empty fruit bunch at 50 °c and ph 6, producing 105.4 g/l of l-lactic acid with a productivity of 9.3 g/l/h by fed-batch fermentation under unsterilized conditions. simultaneous saccharification and fermentation (ssf) was performed at ph 5.5 and 50 °c to convert both hemicellulose hydrolysate and cellulose-lignin complex in the presence of cellic ctec2 cellulases using yeast ...201728436165
inferring microbial interactions in the gut of the hong kong whipping frog (polypedates megacephalus) and a validation using probiotics.the concerted activity of intestinal microbes is crucial to the health and development of their host organisms. investigation of microbial interactions in the gut should deepen our understanding of how these micro-ecosystems function. due to advances in next generation sequencing (ngs) technologies, various bioinformatic strategies have been proposed to investigate these microbial interactions. however, due to the complexity of the intestinal microbial community and difficulties in monitoring th ...201728424669
combined effect of bacillus coagulans gbi-30, 6086 and hmb supplementation on muscle integrity and cytokine response during intense military training.the purpose of this study was to compare the coadministration of the probiotic bacillus coagulans gbi-30, 6086 (bc30) with β-hydroxy-β-methylbutyrate (hmb) calcium (cahmb) to cahmb alone on inflammatory response and muscle integrity during 40 days of intense military training. soldiers were randomly assigned to one of two groups: cahmb with bc30 (cahmbbc30; n = 9) or cahmb with placebo (cahmbpl, n = 9). a third group of participants served as a control (ctl; n = 8). during the first 28 days sold ...201728408697
immunotropic aspect of the bacillus coagulans probiotic action.currently, probiotics are increasingly used as the alternative to antibiotics as well as the preventive measures in humans. in particular, probiotics occupy a key position in the treatment of antibiotics-associated intestinal dysbiosis. a spore-forming microorganism lactobacillus bacillus coagulans is one of the most promising probiotics. however, some of its pharmacological effects remain poorly understood. this study was aimed at investigation of the effect of b. coagulans (laktovit forte) on ...201728397382
coordination of metabolic pathways: enhanced carbon conservation in 1,3-propanediol production by coupling with optically pure lactate biosynthesis.metabolic engineering has emerged as a powerful tool for bioproduction of both fine and bulk chemicals. the natural coordination among different metabolic pathways contributes to the complexity of metabolic modification, which hampers the development of biorefineries. herein, the coordination between the oxidative and reductive branches of glycerol metabolism was rearranged in klebsiella oxytoca to improve the 1,3-propanediol production. after deliberating on the product value, carbon conservati ...201728396036
a brief dataset on the model-based evaluation of the growth performance of bacillus coagulans and l-lactic acid production in a lignin-supplemented medium.the data presented in this article are related to the research article entitled "model-based characterization of growth performance and l-lactic acid production with high optical purity by thermophilic bacillus coagulans in a lignin-supplemented mixed substrate medium (r. glaser and j. venus, 2016) [1]". this data survey provides the information on characterization of three bacillus coagulans strains. information on cofermentation of lignocellulose-related sugars in lignin-containing media is gi ...201728243619
in vitro evaluation of bioremediation capacity of a commercial probiotic, bacillus coagulans, for chromium (vi) and lead (ii) toxicity.the bioaccumulation of heavy metals including chromium (vi) (cr (vi)) and lead (ii) (pb (ii)) causes fatal toxicity in humans. some naturally occurring bacterial genera such as bacillus and pseudomonas help in bioremediation of these heavy metals and some of the species of bacillus are proven probiotics. however, no study has been conducted on bacillus coagulans, which is a proven probiotic species of genus bacillus.201728216949
erratum to: effect of probiotic bacillus coagulans and lactobacillus plantarum on alleviation of mercury toxicity in rat. 201728205137
the effects of bacillus coagulans-fermented and non-fermented ginkgo biloba on abdominal fat deposition and meat quality of peking duck. 201728204698
model-based characterisation of growth performance and l-lactic acid production with high optical purity by thermophilic bacillus coagulans in a lignin-supplemented mixed substrate medium.three bacillus coagulans strains were characterised in terms of their ability to grow in lignin-containing fermentation media and to consume the lignocellulose-related sugars glucose, xylose, and arabinose. an optical-density high-throughput screening was used for precharacterisation by means of different mathematical models for comparison (logistic, gompertz, baranyi, richards & stannard, and schnute). the growth response was characterised by the maximum growth rate and lag time. for a comparis ...201728188935
synthesis, characterization and biological studies of schiff bases derived from heterocyclic moiety.some new schiff bases (h1-h7) have been synthesized by the condensation of 2-aminophenol, 2-amino-4-nitrophenol, 2-amino-4-methylphenol, 2-amino benzimidazole with thiophene-2-carboxaldehyde and pyrrole-2-carboxaldehyde. the structures of newly synthesized compounds were characterized by elemental analysis, ft-ir, (1)h nmr, uv-vis, and single crystal x-ray crystallography. the in vitro antibacterial activity of the synthesized compounds has been tested against salmonella typhi, bacillus coagulan ...201727894775
effect of probiotic bacillus coagulans and lactobacillus plantarum on alleviation of mercury toxicity in rat.the objective of this study was to evaluate the efficiency of probiotics (lactobacillus plantarum and bacillus coagulans) against mercury-induced toxicity using a rat model. mercury (hg) is a widespread heavy metal and was shown to be associated with various diseases. forty-eight adult male wistar rats were randomly divided into six groups (control, mercury-only, each probiotic-only, and mercury plus each probiotic group). hg-treated groups received 10 ppm mercuric chloride, and probiotic groups ...201728084611
inhibition of lipopolysaccharide-induced interleukin 8 in human adenocarcinoma cell line ht-29 by spore probiotics: b. coagulans and b. subtilis (natto).probiotics are used as a treatment for different intestinal disorders. they confer health benefits by different ways. this study was aimed to investigate immunomodulatory effect of bacillus probiotic spores on the production of lipopolysaccharide (lps)-induced interleukin 8 (il-8) in ht-29 intestinal epithelial cells. differentiated intestinal epithelial cell line was used as a model for the study of colonization of purified spores (bacillus subtilis (natto) and b. coagulans) and their anti-infl ...201727785697
development of a systematic feedback isolation approach for targeted strains from mixed culture systems.elucidation of functions of bacteria in a mixed culture system (mcs) such as composting, activated sludge system is difficult, since the system is complicating with many unisolated bacteria. here, we developed a systematic feedback isolation strategy for the isolation and rapid screening of multiple targeted strains from mcs. six major strains (corynebacterium sphenisci, bacillus thermocloacae, bacillus thermoamylovorans, bacillus smithii, bacillus humi, and bacillus coagulans), which are detect ...201727570222
detoxification of sap from felled oil palm trunks for the efficient production of lactic acid.the availability of fermentable sugars in high concentrations in the sap of felled oil palm trunks and the thermophilic nature of the recently isolated bacillus coagulans strain 191 were exploited for lactic acid production under non-sterile conditions. screening indicated that strain 191 was active toward most sugars including sucrose, which is a major component of sap. strain 191 catalyzed a moderate conversion of sap sugars to lactic acid (53%) with a productivity of 1.56 g/l/h. pretreatment ...201728361245
waste-to-biofuel: production of biobutanol from sago waste residues.the main concern of extensive production of biobutanol has been associated with the high cost of the substrate and the relatively low tolerance of clostridia to biobutanol production. in this study, the use of fermentable cassava waste residue (cwr) as substrate for biobutanol production was investigated using solvent-tolerant clostridium sp. four of obligatory, solvent-producing bacteria were isolated from sago industry waste sites. the nsw, pnas1, sb5 and sbi4 strains showed identical profiles ...201728091177
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