Publications

[is campylobacter pylori more frequently observed after antisecretory treatment].		1988	3220228
microabscesses in gastric biopsies shown by acridine orange staining.	acridine orange staining of endoscopic biopsies of gastric mucosa was used in 70 patients with various upper gastrointestinal symptoms to identify campylobacter pylori abscess formations with polymorphonuclear leucocyte infiltration. in comparison with cultures, the staining test proved to be a rapid and reliable test particularly in outpatient clinics as results are available in 6-8 min, thus enabling any necessary treatment to start immediately.	1988	3222670
[occurrence of campylobacter pylori in patients with gastritis and peptic ulcer].	endoscopic biopsies from the gastric antrum and margin of peptic ulcers (gastric and duodenal) were obtained from 56 patients for histologic and microbiologic studies in order to establish the occurrence of campylobacter pylori. thirty nine of them had antral gastritis and in 37 (94.8%) the bacteria was detected. in 17 cases with normal mucosa the culture was positive in only 2 of them (p less than 0.01). patients with duodenal and gastric ulcer had a 100% and 88.8%, respectively, of positivity ...	1988	3223826
retrospective study of campylobacter-like organisms in patients undergoing partial gastrectomy.	one hundred and five stoma biopsy specimens and 108 corpus biopsy specimens from 108 patients who had undergone a partial gastrectomy because of peptic ulcer disease were examined retrospectively for the presence of campylobacter-like organisms and gastritis. in the corpus biopsy specimens campylobacter-associated gastritis was found in 55 (71%) of the cases and in 42 (48%) of the stoma biopsy specimens. it is concluded that campylobacter-like organisms have a role in gastritis after partial gas ...	1988	3225333
campylobacter pylori: clinical, histological, and serological studies.	the presence of campylobacter pylori, histologically diagnosed gastritis, and antibodies to c pylori were determined in a series of 113 patients undergoing endoscopy. paired biopsy specimens from the fundus, body, and antrum were collected from 59 patients and from the antrum of 54 patients. the presence of c pylori was confirmed by either culture or silver stain in 30 of 59, 31 of 59, and 54 of 103 biopsy specimens from the fundus, body, and antrum, respectively. of the specimens which containe ...	1988	3225334
potential transport medium for campylobacter pylori.		1988	3225338
[campylobacter pylori, gastritis, ulcer and defense mechanisms of the gastroduodenal mucosa].		1988	3227126
[role of campylobacter pylori in gastritis and peptic ulcer].		1988	3228729
isoelectric focusing of ureases from campylobacter pylori and related organisms.	agarose gel isoelectric focusing was used to determine the isoelectric points of ureases from strains of gastric campylobacterlike organisms isolated from ferrets (pi 5.4), baboons (pi 5.7), and pigs (pi 5.9) and from isolates of campylobacter pylori in humans (pi 5.9). this technique may help differentiate these closely related bacteria.	1988	3230144
campylobacter pylori--a bacterial cause of peptic ulcer disease.		1988	3233438
metronidazole and campylobacter pylori infection.		1988	3233453
prospective study on the distribution of campylobacter pylori in unselected patients of an endoscopy unit in west germany.	in recent years a series of publications predominantly from english speaking countries have reported on the colonization of the gastric epithelium with campylobacter pylori in association with gastritis and ulcer disease. in this prospective study we investigated the distribution of campylobacter pylori in unselected patients undergoing routine endoscopy at the department of gastroenterology of the university of heidelberg. a total of 175 patients were included in the study. campylobacter pylori ...	1988	3239123
[campylobacter pyloridis: prevalence in normal endoscopies, atrophic gastritis and peptic ulcer].		1988	3244930
campylobacter pylori infection in gastric and duodenal ulcer.	the incidence of infection with campylobacter pylori (cp) in gastric ulcer (gu) and duodenal ulcer (du) and its correlation with the gastritis lesions associated to the two diseases, was investigated. in gu the incidence of cp infection was 76.3%, close to that in du (71.4), but different from controls (33.3%). chronic gastritis associated to gastric or duodenal ulcer is of variable severity, cp infection being the more often encountered the higher the severity of gastritis. presence of cp was a ...	1988	3244989
gastritis--a misused term in clinical gastroenterology.	gastritis is an inflammation in the gastric mucosa. the definition, classification and diagnosis of gastritis is based on morphological changes. the term 'gastritis' is widely used as a catchbag for upper abdominal complaints. although acute or specific forms of gastritis may present upper abdominal symptoms, chronic gastritis is asymptomatic, and is not the cause of long standing upper abdominal complaints. chronic gastritis is a very common condition in the general population. hence the probab ...	1988	3245001
[campylobacter pyloridis and its relation to chronic gastritis and peptic ulcer disease].		1988	3248437
[effect of campylobacter pyloridis and other parietal microflora on gastric epitheliocytes in peptic ulcer and following vagotomy].	using light and transmission electron microscopy, the authors studied the effect of vagotomy on the interaction between the parietal microflora (campylobacter pyloridis, in particular) and gastric epitheliocytes in peptide ulcer patients (n = 80). campylobacter pyloridis abundant in pyloric and antral portions of the stomach following vagotomy was found in still increasing quantities. ultrastructurally, there were alterative changes in parietal microflora-contacting epitheliocytes both in peptic ...	1988	3250384
[campylobacter pylori infection--a new concept of the etiology of stomach diseases].		1988	3251200
[presence of campylobacter pylori in the gastric mucosa of healthy persons and in patients with peptic ulcer and non-ulcer dyspepsia].		1988	3251201
the incidence of campylobacter pylori in chronic gastropathy.		1988	3252770
gc content of dna of campylobacter pylori and other species belonging or related to the genus campylobacter.	dna of type strain campylobacter pylori nctc 11637 and 32 other strains of c. pylori recovered from gastric biopsy specimens was examined by thermal denaturation for its guanine-plus-cytosine (gc) content. the gc content of strain nctc 11637 was 35.6 mol % (standard deviation (sd) 0.3), and the gc content of the 32 other c. pylori strains ranged from 34.1 to 37.5 mol % (average value 35.2, sd 1.0). a total of 14 type strains of other campylobacter and wolinella species were included in this stud ...	1988	3252903
[study of the relationship between campylobacter pyloridis and pathological lesions in 400 bioptic specimens from gastric mucosa].		1988	3254751
rapid urease test provides specific identification of campylobacter pylori in antral mucosal biopsies.	in a prospective study, three antral biopsies were taken from 175 dyspeptic patients during routine endoscopy. one biopsy was inserted immediately into a gel-containing well of a clotest slide and two biopsies were sent to histopathology. using the clotest, 84 of the 175 samples (48%) detected urease activity in the gastric biopsy, suggesting infection with campylobacter pylori. histopathological examination by two independent observers reported that 93 (52%) of the biopsies contained campylobac ...	1988	3256808
lymphocytic gastritis--relationship to campylobacter pylori infection.	the existence of a distinctive form of chronic gastritis characterized by marked infiltration of the surface and pitlining epithelium by mature t lymphocytes has been confirmed. seventeen cases were identified amongst 382 patients with active chronic gastritis (4.5 per cent). the cases with lymphocytic gastritis had significantly higher counts of intraepithelial lymphocytes than sex and age-matched controls drawn from a series of patients with the usual form of active type b chronic gastritis. f ...	1988	3258373
in search of an animal model for experimental campylobacter pylori infection: administration of campylobacter pylori to rodents.	various mouse strains and lewis rats were either orally or intravenously infected with high inocula of campylobacter pylori and bacterial counts in the liver, spleen, heart, kidneys, and the stomach were followed over time. the intravenously infected animals displayed transient bacteremia and colonization of their livers and spleens. a loglinear decrease led to complete bacterial clearance after 72 hours. oral administration of campylobacter pylori neither resulted in colonization nor tissue inv ...	1988	3261481
ménétrier's disease. a trivalent gastropathy.	current conceptions of ménétrier's disease only obliquely resemble those originally described. bona-fide cases are so uncommon that, of 125 cases diagnosed as ménétier's disease, hypertrophic gastritis, or protein-losing gastropathy treated at the massachusetts general hospital during the 26-year period of 1962-1987, only six cases merited an unequivocal anatomic diagnosis. two other cases previously described proved on review to be nondiagnostic in one instance and campylobacter pylori gastriti ...	1988	3264139
campylobacter pylori in children: endoscopic and histopathologic investigations.		1988	3269127
the clinical significance of campylobacter pylori.	campylobacter pylori has recently been isolated from gastric mucosal biopsy specimens. campylobacter pylori has many attributes in common with other campylobacters but it may represent a new genus. it produces abundant quantities of urease, and this property has been used to develop a rapid diagnostic test. the organism is found predominantly beneath the gastric mucus layer that lines the surface epithelium of the stomach. infection with c. pylori causes an acute histologic gastritis which may b ...	1988	3276266
campylobacter pylori. infectious cause of ulcers.		1988	3278646
campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin.	we randomly assigned 45 adult patients with campylobacter pylori-confirmed antral gastritis to 8 days of treatment with 1 g amoxycillin suspension twice a day, or placebo, according to a double-blind study design. at the end of therapy, 91% of patients treated with amoxycillin demonstrated clearance of the organism from the antrum, compared with 16% in the placebo group (p less than 0.001). active antral gastritis resolved in 68% of patients in the amoxycillin group versus only 9% in the placebo ...	1988	3279757
prevention of nitroimidazole resistance in campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies.	one hundred patients with duodenal ulceration and campylobacter pylori in their stomach were entered into a double blind placebo controlled prospective study. treatment schedules were cimetidine and placebo, or cimetidine and tinidazole, or colloidal bismuth subcitrate (cbs) and placebo, or cbs and tinidazole. seventeen per cent of isolates of c pylori obtained at the first endoscopy were resistant to tinidazole and 70% of the second isolates from patients given cimetidine and tinidazole became ...	1988	3280609
[microbiology of campylobacter pylori].	campylobacter pylori is a hitherto unknown spiral bacterium. it is implicated in the pathogenesis of chronic antral type b gastritis and also of duodenal and gastric ulcer disease. however, its causal role has not yet been unequivocally established. taxonomically, c.pylori appears to belong to a genus different from genuine campylobacters, but a precise classification is likewise lacking. the in vitro sensitivity analyses of various antibiotics are complicated by a number of technical difficulti ...	1988	3280931
[therapy of campylobacter pylori infection].	a simple and efficient therapy eradicating c. pylori with high reliability from gastroduodenal mucosae is presently unknown. in regard to such a "puristic" approach, antibiotics given as monotherapy are presently as ineffective as bismuth salts, which may temporarily reduce the bacterial density, but yield a low complete bacterial eradication rate of not more than 10% to 30% of all patients. pilot studies are being performed in many centers to identify more efficacious drugs or combinations. alt ...	1988	3280932
[campylobacter pylori-associated chronic gastritis: a new entity in gastroduodenal diseases?].	clinical, morphological and immunological data in addition to animal studies clearly support the conclusion, that campylobacter pylori infection is a direct cause (sufficient condition) for chronic type b gastritic in man. c. pylori gastritis is primarily a histologic entity defined by the presence of a gastric mucosal cellular infiltrate and the histologic demonstration of typical curved bacilli. preliminary findings indicate, that this infection is not associated with a specific combination of ...	1988	3280934
campylobacter pylori: a newly recognized infectious agent in the gastrointestinal tract.	recent experience with the gastritis-associated organism campylobacter pylori is reviewed, placing special emphasis on pathologic aspects. c. pylori is a spiral, gram-negative, urease-producing bacillus that has been found to infect the stomach in many people. c. pylori organisms are readily seen overlying the gastric epithelium, often in large numbers. demonstration in gastric biopsies with silver stains is most vivid, but other faster, simpler stains such as giemsa, acridine orange, and, at ti ...	1988	3281485
[campylobacter pylori, gastritis and ulcer disease. microbiological, histological and serological studies].	in a prospective study of 70 patients with epigastric pain, gastroduodenoscopy revealed gastric and/or duodenal ulcers in a total of 41 and no ulceration in the remainder. biopsies were taken to assess the severity of gastritis and the presence of campylobacter pylori (cp) by histology and culture. gastritis was found in 54 patients. cp was detected in 78% of the ulcer patients and 52% of the patients without ulcer (p less than 0.05). cp was demonstrated in 83% of the histologically diagnosed ca ...	1988	3282302
immunocytochemical identification of campylobacter pylori in gastritis and correlation with culture.	endoscopic biopsy specimens of antral mucosa from 25 patients presenting with gastric complaints were obtained for culture and histologic and immunocytochemical studies. the histopathologic study revealed chronic gastritis in 22 patients and borderline chronic gastritis in three patients. the unlabeled-antibody peroxidase-antiperoxidase (pap) method was applied for the detection of campylobacter pylori, and its results were compared with those obtained with the culture technique. strongly positi ...	1988	3282485
four hour rapid urease test (rut) for detecting campylobacter pylori: is it reliable enough to start treatment?		1988	3283175
non-ulcer dyspepsia: potential causes and pathophysiology.	dyspepsia, defined as chronic or recurrent upper abdominal pain or nausea, is a common occurrence. dyspepsia without an ulcer (non-ulcer dyspepsia) is diagnosed in patients at least twice as often as peptic ulceration. diseases that may present with similar symptoms include gastroesophageal reflux, biliary tract disease, chronic pancreatitis, and irritable bowel syndrome. a careful history and physical examination, supplemented by selected tests, usually lead to a correct diagnosis. the pathogen ...	1988	3285748
[campylobacter pylori and gastroduodenal pathology in children].	since warren and marshall rediscovered in 1983 the presence of a spiral microorganism on the gastric mucosa, and named it campylobacter pylori (cp), its significance and characteristics have been largely studied. cp has fulfilled koch's postulates, which need to proven before a microorganism can be said to cause a disease. the natural source of infection is unknown, but in human volunteer studies, ingestion of a suspension of cp was followed by the development of severe dyspepsia associated with ...	1988	3287348
[campylobacter pylori, gastritis and gastroduodenal ulcer: more than just a combination].		1988	3287555
campylobacter pylori antibodies in humans.	to determine the diagnostic value of assays to measure serum antibodies to campylobacter pylori, and to use these assays to determine the prevalence of c. pylori infection in a healthy population.	1988	3288028
[campylobacter pylori: cause of gastritis and ulcer disease?].	several studies have shown a striking association between the presence of campylobacter pylori (c.p) in the gastric mucosa and histologically confirmed gastritis and ulcer disease. the microorganism has been found in up to 90% of patients with active chronic antral (type b) gastric ulcer, and in up to 70% of patients with duodenal ulcer. voluntary ingestion of c.p. by two persons and two epidemic occurrences after apparent c.p. contamination of stomach probes, with demonstration of the bacterium ...	1988	3289114
[campylobacter pyloridis: a new pathogenetic hypothesis and new guidelines in the therapy of gastritis and peptic ulcer].		1988	3290723
campylobacter pylori.		1988	3291154
[campylobacter pylori: significance, diagnosis and treatment].	the association between colonization of the antrum mucosa by campylobacter pylori and antrum gastritis as well as peptic ulcers has been documented in a number of studies. the ability of these bacteria to produce a cytotoxin and a protease that hydrolyzes the mucosa-protecting mucin assigns pathogenetic properties to this species that suggest an etiological role for c. pylori in the pathogenesis of peptic ulcers and gastritis. this concept is supported by some preliminary results of therapeutic ...	1988	3292401
campylobacter gastritis and associated disorders.	our review of evidence that campylobacter pylori is an important factor in gastritis, peptic ulcer disease, and "nonulcer dyspepsia" suggests that c pylori is the most common cause of chronic active gastritis. the association between c pylori gastritis and duodenal ulcer, which approaches 100%, leads to the suggestion that this infection plays an important role in the pathogenesis of duodenal ulcer. evidence supporting a central role in the pathogenesis of gastric ulcer and nonulcer dyspepsia is ...	1988	3293234
antacids reduce campylobacter pylori colonization without healing the gastritis in patients with nonulcer dyspepsia and erosive prepyloric changes.	antral biopsy specimens from 89 consecutive patients with nonulcer dyspepsia and erosive prepyloric changes included in a prospective, randomized, double-blind 4-wk study of the effect of an aluminum-magnesium antacid (120 mmol/day) or pirenzepine (50 mg b.i.d.) vs. placebo were examined histologically. campylobacter pylori (cp) was found by light microscopy of silver-stained sections in 25 patients (28%). campylobacter pylori-positive patients were on average older than cp-negative patients (p ...	1988	3294081
[campylobacter pylori--a critical assessment].		1988	3294148
infection with campylobacter pylori.		1988	3294392
[frequency of campylobacter pylori in antral biopsies of patients with indications for upper digestive endoscopy].		1988	2484118
[isolation of campylobacter pylori from the gastric mucosa by gram stain and culture].		1988	3152671
[frequency of campylobacter pylori in gastroduodenal lesions at an outpatient gastroenterology clinic].		1988	3152672
[gastritis in children associated with campylobacter pylori].		1988	3152673
restriction endonuclease analysis of the genome of campylobacter pylori with a rapid extraction method: evidence for considerable genomic variation.	we developed a rapid extraction method to analyze the chromosomal dna of 84 isolates of campylobacter pylori (formerly campylobacter pyloridis) from 70 individuals. only three of the nine endonucleases tested gave satisfactory digestions: hindiii, ecori, and saci. the latter two produced mostly larger bands, whereas hindiii produced smaller bands, which allowed clearer comparisons between isolates. the isolates from 69 australian subjects and one from england each had a unique profile. isolates ...	1988	2830341
susceptibility of campylobacter pylori isolated from pediatric and adult patients to seven new quinolone antibiotics and nalidixic acid.	the susceptibility of 26 strains of campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. all strains were resistant to nalidixic acid. difloxacin, a-56620, a-62254, and ciprofloxacin were equally effective against the test strains with mics ranging from 0.06 to 2.0 micrograms/ml. fleroxacin, amifloxacin, perfloxacin, and norfloxacin showed only moderate activity against c. pylori. the new quinolone agents, which are bactericidal, may prove useful in the eradicat ...	1988	2850140
[study of leukotriene b4 level in gastric mucosa of patients with campylobacter pylori gastritis].		1988	2851669
campylobacter pylori in central africa.		1988	3122939
campylobacter pylori: prospective analysis of clinical and histological factors associated with colonization of the upper gastrointestinal tract.	the association of campylobacter pylori (c.p.) colonization of the upper gastrointestinal tract with five predefined anamnestic variables, seven symptoms of dyspepsia, and various blindly evaluated histological criteria, was prospectively investigated in a consecutive series of 149 patients submitted to upper gastrointestinal tract endoscopy. colonization was determined by biopsy urease tests and histological searches. significant differences (p less than 0.05) between c.p.-positive and c.p.-neg ...	1988	3133219
evaluation of a new selective medium for campylobacter pylori.	contaminating bacteria from the oropharynx and bacteria that colonise the stomachs of patients with a high gastric ph impede the isolation of campylobacter pylori from gastric biopsy specimens. commercially available selective supplements are inhibitory to this organism and therefore a specific selective medium is needed for isolation. potential selective agents were evaluated for their activity against 97 strains of campylobacter pylori. a modification of skirrow's medium was developed; cefsulo ...	1988	3141172
enzyme-linked immunosorbent assay for detection of immunoglobulin a and g antibodies to campylobacter pylori.	an enzyme-linked immunosorbent assay (elisa) employing an acid-glycine extract was used to detect igg and iga antibodies to campylobacter pylori in sera from 179 patients with upper gastrointestinal disease, 174 blood donors and 65 children. the incidence of positive elisa results clearly increased with the severity of histopathologic findings in the antrum mucosa and was also high in patients with peptic ulcers and gastric cancer. the incidence in blood donors and children was much lower and in ...	1988	3141173
susceptibility of clinical isolates of campylobacter pylori to twenty-one antimicrobial agents.	the mics of 21 antimicrobial agents were determined for 97 clinical isolates of campylobacter pylori. the beta-lactams (penicillin, ampicillin, cefoxitin and cephalexin), macrolides (erythromycin and azithromycin), quinolones (ciprofloxacin and ofloxacin), nitrofurans, gentamicin and tetracycline all had mic90 values of less than or equal to 0.5 mg/l. aztreonam, flucloxacillin, amifloxacin and rifampicin had moderate activity. all isolates were resistant to vancomycin, cefsulodin and amphoterici ...	1988	3141174
comparison of different antigen preparations in an evaluation of the immune response to campylobacter pylori.	this study presents a novel approach to the analysis of protein antigens of campylobacter pylori for use in serology. protein fractions of this bacterium were resolved in polyacrylamide gel electrophoresis, eluted from gel strips in an electric field and used for coating of microtiter plates in an elisa-type assay run with a small set of sera from both infected and non-infected patients. reactivity and discriminative power of the different fractionated antigens (1-9) and crude antigen preparatio ...	1988	3141175
demonstration of a cytotoxin from campylobacter pylori.	in order to determine if campylobacter pylori produces a cytotoxin, a study was performed using bacterial lysates from three clinical isolates of the organism. the lysates were cytotoxic for chinese hamster ovary cells, as determined by a microtiter assay. the lysates were also lethal for mice after intraperitoneal injection. loss of toxicity and lethality followed trypsinization, heating and acidification of cell-free lysates. it is concluded that the toxic factor(s) in campylobacter pylori may ...	1988	3141176
in vitro activity of pentacaine against campylobacter pylori.		1988	3141177
possible pathogenic mechanisms of campylobacter pylori.		1988	3141178
risk factors for persistent diarrhoea.	with a systematically sampled population of children aged under 5 attending this centre for diarrhoeal disease research during 1983-5 a retrospective analysis of persistent diarrhoea (defined as greater than 14 days' duration) was performed to identify the possible risk factors for this syndrome. of the 4155 children included in the analysis, 410 (10%) gave a history of persistent diarrhoea. a comparison with children with acute diarrhoea matched for age showed that 11 factors were correlated wi ...	1988	3142603
campylobacter pylori in gastroduodenal disease.		1988	3144601
[the urease test for the diagnosis of campylobacter pylori infection].	to evaluate the usefulness of urea media routinely applied in the diagnosis of campylobacter pylori infection, 50 patients with gastroduodenal pathology were studied. two biopsies of antral mucosa were taken; one of them was placed on urea agar base (difco) prepared without agar, and the other in saline for gram staining and culture in selective and enriched media. in 39 patients campylobacter pylori was found by gram staining and/or culture. 38 of them were urease test positive, 24 (61.5%) duri ...	1989	2485236
isolation of campylobacter pyloridis from nigerian patients with gastroduodenal pathology.	recent reports have indicated that campylobacter pyloridis may be a causative factor in upper digestive pathology. gastric and duodenal biopies were taken from 144 patients undergoing upper digestive endoscopy as part of investigation for dyspeptic symptoms at the endoscopy unit of lagos university teaching hospital between october, 1985 and november, 1986 employing acmi gastroduodenoscope model tx-7. the first 50 specimens were placed in 3 ml of brain heart infusion and taken to the microbiolog ...	1989	2486780
campylobacter pylori in upper digestive tract diseases in children.	results of studies on the frequency of the occurrence of the bacteria, campylobacter pylori, in the mucous membrane of the gastric antrum are presented in this paper. the study was carried out on 61 children treated for chronic abdominal pain. the diagnosis was established on the basis of flexible endoscopy and histology of antral biopsies. the presence of campylobacter pylori was determined using the clo-test. the positive clo-test was obtained in 87.5% of children with gastritis, in 75% of chi ...	1989	2489238
[in vitro activity of 16 antimicrobial agents against helicobacter (campylobacter) pylori].	campylobacter pylori has been associated with the etiology of gastritis and duodenal ulcer. it has been shown that several drugs, among them a variety of antimicrobials, eliminate c. pylori from gastric mucosa at least for a time, resulting in an improvement of the patients' symptoms. the activity of 16 antimicrobials (ampicillin, cefazolin, cefuroxime, cefotaxime, imipenem, aztreonam, tigemonam, erythromycin, vancomycin, nalidixic acid, colistin , norfloxacin, ciprofloxacin, difloxacin, ofloxac ...	1989	2490433
[pathogenicity of campylobacter pylori in the digestive tract].		1989	2490635
animal models for campylobacter pylori infection.		1989	2490934
campylobacter pylori absence in extragastric human intestinal sites and animal stomachs.		1989	2491306
peptic ulcer: from epidemiology to cause.	any postulate that attempts to explain the aetiology of peptic ulcer must take into consideration a number of established facts. (i) at the beginning of the 20th century there was a steep rise in the incidence of peptic ulcers. over the past 2 decades, trends have shown a significant decline in some western countries, such as the united kingdom, and a significant rise in certain asian countries, such as hong kong and singapore. (ii) there are marked geographical variations in incidence (for exam ...	1989	2491356
[campylobacter pylori and the gastric mucosa. apropos of the detection of campylobacter pylori in 12 patients with gastric mucosa lesions].	the authors report the results of systematic research on campylobacter pylori during high endoscopy. of the 60 patients examined, 12 were found to have the germ in their antral, gastric mucosa. all these patients had a history of chronic gastritis. they recall the role of this germ in creating chronic gastritis, and evoke the hypothesis that the mucosa becomes fragile facilitating the appearance of an ulcer.	1989	2491383
campylobacter pylori gastritis: long term results of treatment with amoxycillin.	to evaluate the efficacy of amoxycillin in eradicating campylobacter pylori, endoscopic biopsy specimens were taken from the antral mucosa of 40 children with gastritis before, immediately after, and (in 30 patients) three months after treatment. immediately after treatment 34 patients (85%) no longer had the organism in the mucosa, and the gastritis had healed in 23 (58%). three months later the infection had recurred in 22 of 30 patients (73%), and the gastritis had relapsed in all of them. si ...	1989	2495776
biotypes of campylobacter pylori isolated in gastroduodenal biopsies.		1989	2498104
use of the mouse for the isolation and investigation of stomach-associated, spiral-helical shaped bacteria from man and other animals.	spiral-helical shaped bacteria other than campylobacter pylori have been shown to infect the human stomach. the characteristic helical morphology of these bacteria appears to be similar to that of bacteria found in the stomachs of many other animal species. early reports on gastric bacteria suggested that rodents may be useful for investigation and isolation of stomach-associated bacteria. therefore, anaesthetised mice were given, through a stomach tube, a heavy suspension of a spiral-helical ba ...	1989	2498521
dna-dna hybridization incompatibility of campylobacter pylori with other campylobacter and wolinella species.	dna-dna hybridization in solution was used to characterize 23 human isolates of campylobacter pylori. the 23 isolates showed dna affinity with the type strain (nctc 11637). the relative binding ratios varied between 0.83 and 1. type strains of c. coli (nctc 11366), c. jejuni (nctc 11351), c. laridis (nctc 11352), c. sputorum subsp. sputorum (atcc 35980), wolinella recta (nctc 11489) and w. succinogenes (atcc 29543) showed relative binding ratios less than 0.01 compared to the c. pylori type stra ...	1989	2499346
seroepidemiological study of the immune response to campylobacter pylori in potential risk groups.	to gain more understanding of the epidemiology of campylobacter pylori infection, the immune response to the organism was studied in the following selected potential risk groups: endoscopy staff (n = 45), dental staff (n = 58), orphanage children (n = 24), psychiatric patients (n = 58), and family contacts of campylobacter pylori-infected patients (n = 55). the frequency of an igg and iga antibody response in the different groups was determined by the immunoblot method and compared with that in ...	1989	2506018
influence of media supplements on growth and survival of campylobacter pylori.	experiments were designed to determine the role of heme and the importance of other factors in the growth of campylobacter pylori. campylobacter pylori strains were tested for their ability to synthesize porphyrin, for their ability to grow and be maintained on basal medium and basal medium supplemented with blood or blood products, and for the influence of bovine serum albumin and catalase on viability. results indicated that campylobacter pylori does not require heme as a source of porphyrin. ...	1989	2506019
haemolytic activity of campylobacter pylori.	the haemolytic activity of several clinical and reference strains of campylobacter pylori was determined using cell-free preparations of broth-grown organisms and human, horse, guinea pig, rabbit and sheep erythrocytes. significant levels of haemolysis were produced only when the cell-free preparations were concentrated tenfold. however, three of 14 strains still gave haemolysis values of less than 50% when tested with guinea pig erythrocytes. significant haemolytic activity could not be demonst ...	1989	2506037
lactobacillus acidophilus inhibits growth of campylobacter pylori in vitro.	campylobacter pylori has been implicated as a causative factor in acid-peptic disease. lactobacillus acidophilus is known to inhibit the growth of pathogens in the human gastrointestinal tract. we recovered c. pylori from gastric antral biopsies of seven patients with acid-peptic disease; the isolates were then cultured in brucella broth. the effect of l. acidophilus (cultured in deman-rogosa-sharpe broth) on the growth of c. pylori was tested by a mixed culture technique. l. acidophilus inhibit ...	1989	2511224
campylobacter pylori, duodenal ulcer disease, and gastrin.		1989	2511976
effect of varying ph on the susceptibility of campylobacter pylori to antimicrobial agents.	the susceptibility of 22 clinical isolates of campylobacter pylori to eight antimicrobial agents was studied under varying ph conditions. macrolides (erythromycin, dirythromycin), clindamycin and to a lesser extent quinolones lost efficacy at lowered ph. the activity of ampicillin and metronidazole remained relatively stable throughout the ph range tested. the effect of ph an antimicrobial efficacy may warrant consideration when selecting an antibiotic to clear campylobacter pylori in vivo, sinc ...	1989	2512133
antral helicobacter pylori, hypergastrinaemia, and duodenal ulcers: effect of eradicating the organism.		1989	2514864
review article: antibiotics and the gut.	antibiotics have an important place in the management of gastrointestinal disease. recent studies have demonstrated efficacy in acute bacterial gastroenteritis caused by salmonellae and campylobacteriaceae, shigellae and enterotoxigenic strains of e coli (etec). tetracycline remains effective in cholera. antibiotic resistance is widespread amongst the enteric pathogens and can quickly spread during epidemics of infective diarrhoeas. it is important that antibiotics are reserved for the treatment ...	1989	2518846
campylobacter pylori infection and gastric mucosal lesions in patients with chronic liver diseases.		1989	2519092
[isolation of campylobacter pylori from gastric biopsies in people from the south of chile].		1989	2519366
nsaids: new approaches to limiting gastropathy.	an extensive literature search on non-steroidal anti-inflammatory drug (nsaid)-induced gastropathy in rheumatic conditions has been carried out. a reduced incidence of gastropathy has been observed among newly developed nsaids such as etodolac and the non-acidic nabumetone. an alternative prophylactic therapy to avoid nsaid-induced gastroduodenal mucosal damage which has been successfully tested in several trials is co-medication with the prostaglandin analogue misoprostol. the cytoprotective ag ...	1989	2525273
[frequency of campylobacter pylori in apparently healthy and asymptomatic venezuelans].	we evaluated 21 healthy asymptomatic venezuelan volunteers free of risk factors for gastritis with upper gastrointestinal endoscopy, and four antral biopsies: a)2 for histological examinations, b) urease test, c) culture and gram coloration. 13 out of 21 subjects were positive for campylobacter pylori (61.30%) all of them had chronic gastritis and in the negative cases 7 were considered histologically normal. urease test was positive in 12/13 with a sensitivity of 92% and 100% specificity. frequ ...	1989	2535448
[comparison of urease test (clotest) and histology in the diagnosis of campylobacter pylori].	campylobacter pylori has been implicated in the pathogenesis of peptic ulcer, non-ulcer dyspepsia and chronic gastritis. c. pylori produces large amounts of urease which has been used as a biochemical support to identify the microorganism. in this study, we described the use of a rapid urease test (clotest) to detect c. pylori. in 46 consecutive patients, biopsy of fundus and antrum were obtained for histology and clotest. all specimens showed chronic gastritis. in 22 patients (48%) c. pylori wa ...	1989	2535449
seroepidemiology of campylobacter pylori infection in various populations.	campylobacter pylori infection has been recognized as being strongly associated with chronic gastritis and duodenal ulceration, but the prevalence of c. pylori infection in a normal population is not known. a serological survey was conducted in four countries with different geographical and socioeconomic status, in a randomly chosen population as representative as possible, by using an enzyme-linked immunosorbent assay (elisa) with a sonic extract of two strains as the antigen. the test had a sp ...	1989	2549098
in-vitro susceptibility of campylobacter pylori to quinolones.		1989	2551872
duodenal ulcer and campylobacter pylori.		1989	2563492
duodenal ulcer relapse after eradication of campylobacter pylori.		1989	2563535
routine cleaning and the elimination of campylobacter pylori from endoscopic biopsy forceps.	the effect of routine cleaning in removing campylobacter pylori from the biopsy forceps of endoscopes has been examined in a series of 50 patients. campylobacter pylori was isolated from the biopsies of 15 of the patients, while one of the 50 biopsy forceps washings yielded the organism after routine cleaning. this study suggests that there is a small chance of transmitting c. pylori by endoscopic equipment if cleaning is the only method of decontamination adopted.	1989	2564022
amoxycillin plus tinidazole for campylobacter pylori gastritis in children: assessment by serum igg antibody, pepsinogen i, and gastrin levels.	32 children (mean age 12 years, range 6-18) with non-specific abdominal pain and campylobacter pylori positive gastritis received a six week course of daily oral amoxycillin (50 mg/kg) and tinidazole (20 mg/kg). before treatment and one month after stopping treatment, endoscopic biopsy samples were taken from the antral mucosa and serum c pylori igg antibody, pepsinogen i, and gastrin levels were measured in fasting blood samples. one month after treatment 30 children (94%) were cleared of c pyl ...	1989	2564507