Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| trichomonas vaginalis is rare among women in iceland. | 2017 | 28681060 | |
| genotyping, drug susceptibility and prevalence survey of trichomonas vaginalis among women attending gynecology clinics in hamadan, western iran, in 2014-2015. | in spite of sufficient knowledge about phenotypic variation of trichomonas vaginalis, its genetic characteristics are poorly understood. we carried out a molecular epidemiology study in which in vitro metronidazole susceptibility of t. vaginalis isolates was considered. | 2017 | 28761458 |
| evaluating the utility of syndromic case management for three sexually transmitted infections in women visiting hospitals in delhi, india. | utility of syndromic case management (scm) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. to understand the effectiveness and/or inadequacies of scm, 11000 women were recruited and examined by clinicians for infection by chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), bacterial vaginosis (bv) ... | 2017 | 28469158 |
| parents' and teachers' views on sexual health education and screening for sexually transmitted infections among in-school adolescent girls in kenya: a qualitative study. | to successfully develop and implement school-based sexual health interventions for adolescent girls, such as screening for chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis, it is important to understand parents' and teachers' attitudes towards sexual health education and acceptability of sexually transmitted infection (sti) screening interventions. | 2017 | 28806985 |
| polyamine transport and synthesis in trichomonas vaginalis: potential therapeutic targets. | polyamines are essential for many biological processes in all organisms. here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. this review focused on the synthesis, interconversion and function of these molecules in trichomonas vaginalis, a common sexually transmitted parasit ... | 2017 | 28671057 |
| trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race/ethnicity in the plco trial. | results from previous sero-epidemiologic studies of trichomonas vaginalis infection and prostate cancer (pca) support a positive association between this sexually transmitted infection and aggressive pca. however, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between t. vaginalis seropositivity and pca in african-american men who are at highest risk of both infection and pca. therefore, we examined this possible relation in the pr ... | 2017 | 28669054 |
| therapeutic effects of iranian herbal extracts against trichomonas vaginalis | trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are fda approved drugs recommended for trichomoniasis treatment. treatment with metronidazole 5'-nitroimidazole derivatives is associated with many side effects, and drug resistance to metronidazole has been reported in some cases. rec ... | 2017 | 28755655 |
| antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives. | the 7-benzylidenenaltrexone (bntx) derivatives 2a-v, 3a-c, 13a-c, and 14a were synthesized from naltrexone (1) and evaluated for their antitrichomonal activity. the structure-activity-relationship studies found that 4-iodo-bntx (2g) showed the highest activity (ic50=10.5µm) and the affinity for the opioid receptor was less important for antitrichomonal activity against trichomonas vaginalis. the morphinan skeleton bearing both the double bond for a michael acceptor and the phenolic hydroxy group ... | 2017 | 28662966 |
| candidatus mycoplasma girerdii replicates, diversifies, and co-occurs with trichomonas vaginalis in the oral cavity of a premature infant. | genital mycoplasmas, which can be vertically transmitted, have been implicated in preterm birth, neonatal infections, and chronic lung disease of prematurity. our prior work uncovered 16s rrna genes belonging to a novel, as-yet-uncultivated mycoplasma (lineage 'mnola') in the oral cavity of a premature neonate. here, we characterize the organism's associated community, growth status, metabolic potential, and population diversity. sequencing of genomic dna from the infant's saliva yielded 1.44 gb ... | 2017 | 28630471 |
| prevalence of human papillomavirus, chlamydia trachomatis, and trichomonas vaginalis infections in amazonian women with normal and abnormal cytology. | sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. we investigated the prevalence of human papillomavirus (hpv), chlamydia trachomatis (ct), and trichomonas vaginalis (tv), and accessed the diversity of hpv in women with normal and abnormal cytology in manaus, brazil. we used polymerase chain reaction and hpv genotyping by direct sequencing. the chi-square test wa ... | 2017 | 28453175 |
| profile of the triplex assay for detection of chlamydia, gonorrhea and trichomonas using the bd max™ system. | chlamydia, gonorrhea and trichomonas are the most common curable sti. improved access to testing could reduce infection rates and prevent sequelae. nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. areas covered: a description of the bd max™ system (max) and the bd max ct/gc/tv assay is provided along with data from a large us clinical trial. the capacity of the system for other tests and for lab developed assays is al ... | 2017 | 28425774 |
| dorsal longitudinal foreskin cut is associated with reduced risk of hiv, syphilis and genital herpes in men: a cross-sectional study in papua new guinea. | various forms of penile foreskin cutting are practised in papua new guinea. in the context of an ecological association observed between hiv infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level. | 2017 | 28406272 |
| results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria. | urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. the objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction ... | 2017 | 28735999 |
| genetic indicators of drug resistance in the highly repetitive genome of trichomonas vaginalis. | trichomonas vaginalis, the most common nonviral sexually transmitted parasite, causes ∼283 million trichomoniasis infections annually and is associated with pregnancy complications and increased risk of hiv-1 acquisition. the antimicrobial drug metronidazole is used for treatment, but in a fraction of clinical cases, the parasites can become resistant to this drug. we undertook sequencing of multiple clinical isolates and lab derived lines to identify genetic markers and mechanisms of metronidaz ... | 2017 | 28633446 |
| detecting the diversity of mycoplasma and ureaplasma endosymbionts hosted by trichomonas vaginalis isolates. | objectives: the symbiosis of trichomonas vaginalis and mycoplasma hominis is the first described association between two obligate human parasites. trichomonas is the niche and the vector for the transmission of m. hominis infection. this clinically significant symbiosis may affect t. vaginalis virulence and susceptibility to treatment. the aims of this study were to investigate the intracellularly present mycoplasma and ureaplasma species in t. vaginalis strains isolated from the vaginal dischar ... | 2017 | 28702014 |
| double-stranded rna viral infection of trichomonas vaginalis (tvv1) in iranian isolates. | the totiviridae family includes a number of viruses that can infect protozoan parasites such as leishmania and giardia and fungi like saccharomyces cerevisiae. some isolates of trichomonas vaginalis are also infected with one or more double-stranded rna (dsrna) viruses. in this study, the frequency of trichomonas vaginalis virus (tvv1) was evaluated in iranian isolates of t. vaginalis in tehran, iran. one thousand five hundred vaginal samples were collected from patients attending obstetrics and ... | 2017 | 28478201 |
| cryo-em structures of the 80s ribosomes from human parasites trichomonas vaginalis and toxoplasma gondii. | as an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. high-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. with cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, trichomonas vaginalis ... | 2017 | 28809395 |
| role of α-actinin 2 in cytoadherence and cytotoxicity of trichomonas vaginalis. | trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. t. vaginalis α-actinin 2 (tvα-actinin 2), has been used to diagnose trichomoniasis. tvα-actinin 2 was dissected into three parts, the n-terminal, central, and c-terminal portions of the protein (#1, #2, and #3, respectively). western blot of these tvα-actinin 2 proteins with pooled patients' sera indicated that tvα-actinin 2 #2 and #3, but not tvα-actinin 2 #1, reacted with those sera. immunofluorescence assays o ... | 2017 | 28838225 |
| vaginal infections in haitian immigrant women living in miami, florida. | to characterize vulvovaginal candidiasis (vc), trichomonas vaginalis (tv), and bacterial vaginosis (bv) among haitian women living in miami to identify contributing factors to cervical cancer disparity in this population. | 2017 | 28804083 |
| a competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase. | the protozoan parasite trichomonas vaginalis contains two nearly identical triosephosphate isomerases (tvtims) that dissociate into stable monomers and dimerize upon substrate binding. herein, we compare the role of the "ball and socket" and loop 3 interactions in substrate assisted dimer assembly in both tvtims. we found that point mutants at the "ball" are only 39 and 29-fold less catalytically active than their corresponding wild-type counterparts, whereas loop 3 deletions are 1502 and 9400-f ... | 2017 | 28803140 |
| audit of trichomonas vaginalis test requesting by community referrers after a change from culture to molecular testing, including a cost analysis. | trichomonas vaginalis (tv) prevalence varies among different communities and peoples. the availability of robust molecular platforms for the detection of tv has advanced diagnosis; however, molecular tests are more costly than phenotypic methodologies, and testing all urogenital samples is costly. we recently replaced culture methods with the aptima trichomonas vaginalis nucleic acid amplification test on specific request and as reflex testing by the laboratory, and have audited this change. | 2017 | 28617786 |
| trichomonas vaginalis is very rare among women with vaginal discharge in podlaskie province, poland. | trichomonas vaginalis is the most common curable sexually transmitted pathogen globally. however, in the european union (eu), trichomoniasis appears to be a rare condition. the aim of this study was to examine the prevalence of t. vaginalis among females attending an sti centre in bialystok, poland, using the highly sensitive and specific aptima t. vaginalis assay. consecutive females, referred by gynaecologists mainly because of abnormal vaginal discharge, were diagnosed using wet mount microsc ... | 2017 | 28612378 |
| unique trichomonas vaginalis gene sequences identified in multinational regions of northwest china. | trichomonas vaginalis (t. vaginalis) is a flagellated protozoan parasite that infects humans worldwide. this study determined the sequence of the 18s ribosomal rna gene of t. vaginalis infecting both females and males in xinjiang, china. samples from 73 females and 28 males were collected and confirmed for infection with t. vaginalis, a total of 110 sequences were identified when the t. vaginalis 18s ribosomal rna gene was sequenced. these sequences were used to prepare a phylogenetic network. t ... | 2017 | 28603223 |
| the fluorescent protein ilov outperforms egfp as a reporter gene in the microaerophilic protozoan trichomonas vaginalis. | trichomonas vaginalis is a flagellated protozoan causing a notorious urogenital infection in humans. due to its anaerobic metabolism, an alternative fluorescent protein that can be readily expressed in oxygen-deprived conditions is ideal. this study assessed the performance of ilov, which does not require oxygen to function, as compared to the conventional enhanced green fluorescent protein (egfp) in t. vaginalis. the results indicated that ilov outperforms egfp in both transient and stable expr ... | 2017 | 28602728 |
| potential of synthetic endoperoxides against trichomonas vaginalis in vitro. | metronidazole is well known for medicine against trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. here, we noticed the killing effects of endoperoxide compounds, n-89 and n-251 as new antimalarial drug candidates, on t. vaginalis and searched the possibility of development of new medicine. we added each of metronidazole, artemisinin, ... | 2017 | 28571765 |
| c-reactive protein is differentially modulated by co-existing infections, vitamin deficiencies and maternal factors in pregnant and lactating indigenous panamanian women. | the usefulness of c-reactive protein (crp) as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common. | 2017 | 28571565 |
| strategies for prevention and treatment of trichomonas vaginalis infections. | the last estimated annual incidence of trichomonas vaginalis worldwide exceeds that of chlamydia and gonorrhea combined. this critical review updates the state of the art on advances in t. vaginalis diagnostics and strategies for treatment and prevention of trichomoniasis. in particular, new data on treatment outcomes for topical administration of formulations are reviewed and discussed. | 2017 | 28539504 |
| a community based study on pelvic inflammatory disease in postmenopausal females: microbiological spectrum and socio-demographic correlates. | pelvic inflammatory disease (pid) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. very few studies have been done regarding post-menopausal pid. | 2017 | 28511414 |
| interaction between trichomonas vaginalis and the prostate epithelium. | most men infected with trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. this has been hypothesized to result in chronic persistent prostatic infection. adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for t. vaginalis infection. adhesion of t. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by t. vaginalis. th ... | 2017 | 28506046 |
| differential protein expressions in virus-infected and uninfected trichomonas vaginalis. | protozoan viruses may influence the function and pathogenicity of the protozoa. trichomonas vaginalis is a parasitic protozoan that could contain a double stranded rna (dsrna) virus, t. vaginalis virus (tvv). however, there are few reports on the properties of the virus. to further determine variations in protein expression of t. vaginalis, we detected 2 strains of t. vaginalis; the virus-infected (v(+)) and uninfected (v(-)) isolates to examine differentially expressed proteins upon tvv infecti ... | 2017 | 28506033 |
| glycogen synthase from the parabasalian parasite trichomonas vaginalis: an unusual member of the starch/glycogen synthase family. | trichomonas vaginalis, a parasitic protist, is the causative agent of the common sexually-transmitted infection trichomoniasis. the organism has long been known to synthesize substantial glycogen as a storage polysaccharide, presumably mobilizing this compound during periods of carbohydrate limitation, such as might be encountered during transmission between hosts. however, little is known regarding the enzymes of glycogen metabolism in t. vaginalis. we had previously described the identificatio ... | 2017 | 28465215 |
| immunocytochemistry improving the diagnosis of trichomonas vaginalis infections. | the aim of this study was to evaluate the immunocytochemistry (icc) to diagnose trichomoniasis, particularly asymptomatic infections. by culture serial dilutions, icc was able to detect 1 trophozoite/ml, while the culture was positive up to 100 trophozoites/ml. the icc in vivo detection capability was assessed in vaginal secretions of mice experimentally infected and in vaginal swabs from asymptomatic hiv-positive pregnant women compared with culture. all vaginal secretion samples from mice were ... | 2017 | 28424786 |
| ureaplasma urealyticum and u. parvum in sexually active women attending public health clinics in brazil. | ureaplasma urealyticum and u. parvum have been associated with genital infections. the purpose of this study was to detect the presence of ureaplasmas and other sexually transmitted infections in sexually active women from brazil and relate these data to demographic and sexual health, and cytokines il-6 and il-1β. samples of cervical swab of 302 women were examined at the family health units in vitória da conquista. the frequency of detection by conventional pcr was 76·2% for mollicutes. in qpcr ... | 2017 | 28637523 |
| urinary meatal swabbing detects more men infected with mycoplasma genitalium and four other sexually transmitted infections than first catch urine. | urinary meatal swabs compared with urine showed higher infection rates for mycoplasma genitalium (15.3% vs 12.6%, p = 0.035), chlamydia trachomatis (11.3% vs 9.3%, p = 0.039), neisseria gonorrhoeae (1.4% vs 1.1%, p = 1.00), trichomonas vaginalis (8.0% vs 1.7%, p < 0.001), and high-risk human papillomavirus (5.9% vs 3.4%, p = 0.078) respectively. | 2017 | 28703728 |
| prevalence and risk factors associated with sexually transmitted infections (stis) among women of reproductive age in swaziland. | sexually transmitted infections (stis) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. epidemiological data on stis among women of reproductive age in swaziland are limited. the availability of epidemiological data on stis and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. the study aimed to determine the prevale ... | 2017 | 28559923 |
| expression of the enzymatically active legumain-like cysteine proteinase tvlegu-1 of trichomonas vaginalis in pichia pastoris. | the legumain-like cysteine proteinase tvlegu-1 from trichomonas vaginalis plays a major role in trichomonal cytoadherence. however, its structure-function characterization has been limited by the lack of a reliable recombinant expression platform to produce this protein in its native folded conformation. tvlegu-1 has been expressed in escherichia coli as inclusion bodies and all efforts to refold it have failed. here, we describe the expression of the synthetic codon-optimized tvlegu-1 (tvlegu-1 ... | 2017 | 28419821 |
| a diagnostic and symptomatological study on trichomoniasis in symptomatic pregnant women in rafsanjan, south central iran in 2012-13. | trichomonas vaginalis, the causative agent of trichomoniasis, is responsible for more than half of all sexually transmitted infections (stis). the present study aimed to determine the frequency of t. vaginalis infection and its clinical manifestations in symptomatic pregnant women in the area based on four different diagnostic methods. | 2017 | 26622305 |
| prevalence, clinical criteria and sociodemographic predictors of trichomonas vaginalis infection in suspected egyptian women, using direct diagnostic techniques. | the present study aimed to determine the prevalence and associated risk factors of vaginal trichomoniasis in women referred to gynecologic clinic in benha university hospital, egypt. | 2017 | 26622298 |