Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| access of black, hispanic, and nonprivately insured women to liquid-based cytology, human papillomavirus dna testing, and on-site colposcopy in the united states. | to determine whether patient race, ethnicity, or insurance status was associated with access to cervical cancer screening with liquid-based cytology (lbc) and with human papillomavirus (hpv) dna testing and with access to on-site colposcopy at the provider's principal practice site. | 2009 | 19098602 |
| immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine in healthy boys aged 10-18 years. | the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine (cervarix) has been shown to be well-tolerated and immunogenic in females aged 10 to 55 years, and up to 100% effective for the prevention of hpv-16/18 infection and associated precancerous cervical lesions in females aged 15 to 25 years. this study is the first to evaluate the immunogenicity and safety of the vaccine in males. | 2009 | 19101456 |
| asymmetric gp5+/6+ pcr and hybridization with fluorescence polarization assay of 15 human papillomavirus genotypes in clinical samples. | the detection of a broad spectrum of hpv genotypes has not been used widely in cervical cancer screening due to technical difficulties and high costs. | 2009 | 19144564 |
| molecular hpv typing as a diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung. | in this study, typing of human papilloma virus (hpv) was performed in squamous cell carcinomas of the lung (n=26) as well as putative primaries of head and neck (n=21) and female genital tract (n=5) of the same patients, to test whether additional information to discriminate lung primaries from metastases can be gained by a direct comparison of the hpv status in both tumors. in 3 (14.2%) patients with head and neck as well as lung squamous cell carcinoma, an identical hpv subtype could be detect ... | 2009 | 19145203 |
| prevalence of human papillomavirus genotypes in women from a rural region of puebla, mexico. | to determine the prevalence of human papillomavirus (hpv) genotypes 6, 11, 16, 18, and 31 in mexican women living in rural areas of puebla, mexico and to evaluate risk factors associated with cervical neoplasm in this population. | 2009 | 19147384 |
| chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas. | cervical cancer develops from precancerous high-grade cervical intraepithelial neoplasia (cin) harboring a transforming infection with high-risk human papillomavirus, which is characterized by p16(ink4a) overexpression. once such a lesion has developed, progression toward an invasive squamous cell carcinoma (scc) may take one or more decades, underlining the heterogeneity of these lesions in terms of duration of existence and progression risk. we performed array-based comparative genomic hybridi ... | 2009 | 19147580 |
| anticancer effects on tacc3 by treatment of paclitaxel in hpv-18 positive cervical carcinoma cells. | previously, we used proteome analysis to identify transforming acidic coiled coil (tacc) 3 as a protein that is down-regulated upon paclitaxel treatment in cervical cancer cells. tacc3 mrna and protein levels decreased after paclitaxel treatment in a time- and dose-dependent manner, and the transactivation of tacc3 promoter was dramatically diminished by paclitaxel. importantly, paclitaxel treatment and knockdown of tacc3 by sirna led to a synergistic enhancement of significant g2/m phase arrest ... | 2009 | 19148534 |
| interaction between human papillomavirus type 5 e2 and polo-like kinase 1. | the e2 protein of the papillomavirus plays an essential role in the viral life cycle. through a yeast two-hybrid screening, human polo-like kinase 1 was found to interact with human papillomavirus type 5 e2. further characterization identified that the domains responsible for the interaction are the transactivation domain of hpv-5 e2 and the sequence between the kinase and the polo box domains of plk1. in vivo, plk1 and hpv-5 e2 are colocalized at the nuclear speckles. in the skin epithelium not ... | 2009 | 19152411 |
| high-risk hpv types in lesions of the uterine cervix of female commercial sex workers in the philippines. | in order to prevent cervical cancer, vaccines against human papilloma virus types 16 (hpv-16) and 18 (hpv-18) have been implemented worldwide. however, the hpv types that cause cancer can differ according to geographical area and ethnicity. in this new era of the hpv vaccine, it is important to elucidate the prevalent hpv types in each area. therefore, the prevalence of hpv infection and cervical abnormalities among 369 female commercial sex workers in the philippines were examined. hpv l1 gene ... | 2009 | 19152419 |
| gene expression patterns induced by hpv-16 l1 virus-like particles in leukocytes from vaccine recipients. | human papillomavirus (hpv) virus-like particle (vlp) vaccines were recently licensed. although neutralizing ab titers are thought to be the main effectors of protection against infection, early predictors of long-term efficacy are not yet defined and a comprehensive understanding of innate and adaptive immune responses to vaccination is still lacking. here, microarrays were used to compare the gene expression signature in hpv-16 l1 vlp-stimulated pbmcs from 17 vaccine and 4 placebo recipients be ... | 2009 | 19155521 |
| a strained dna binding helix is conserved for site recognition, folding nucleation, and conformational modulation. | nucleic acid recognition is often mediated by alpha-helices or disordered regions that fold into alpha-helix on binding. a peptide bearing the dna recognition helix of hpv16 e2 displays type ii polyproline (pii) structure as judged by ph, temperature, and solvent effects on the cd spectra. nmr experiments indicate that the canonical alpha-helix is stabilized at the n-terminus, while the pii forms at the c-terminus half of the peptide. re-examination of the dihedral angles of the dna binding heli ... | 2009 | 19156829 |
| characterization of immortalized human epidermolysis bullosa simplex (krt5) cell lines: trimethylamine n-oxide protects the keratin cytoskeleton against disruptive stress condition. | epidermolysis bullosa simplex (ebs) is an autosomal inherited mechano-bullous disease, characterized by intraepidermal blistering and skin fragility caused by mutations in the keratin (krt) 5 or 14 genes. despite a vast knowledge about the intermediate filament pathology in this disease, the progress in therapy has been slow. animal models and well-characterized continuous cell culture models of ebs are needed prior to clinical testing. | 2009 | 19157792 |
| a type-specific study of human papillomavirus prevalence in cervicovaginal samples in three different spanish regions. | human papillomavirus (hpv) is the most frequent sexually transmitted viral infection. it is necessary to know hpv genotype distribution to identify how many women will be protected by hpv vaccines. during a period of 18 months, we have analyzed 2362 hpv positive reporting data from a secondary demand screening program in three regions in spain (cantabria, leon and burgos). the study has been conducted using polymerase chain reaction and tube array hybridization covering the 35 hpv genotypes desc ... | 2009 | 19161533 |
| induction of focal epithelial hyperplasia in tongue of young bk6-e6/e7 hpv16 transgenic mice. | squamous cell carcinoma (scc) of the oral cavity is one of the most common neoplasms in the world. during the past 2 decades, the role of high-risk human papilloma virus (hr-hpv) has been studied and the data supporting hpv as a one of the causative agents in the development and progression of a sub-set of head and neck squamous cell carcinomas (hnscc) has accumulated. in order to investigate the role of hr-hpv oncogene expression in early epithelial alterations in vivo, we produced transgenic m ... | 2009 | 19165615 |
| the bcl-xl inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma. | keratoacanthoma (ka) is difficult to histologically distinguish from squamous cell carcinoma (scc). therefore, although ka is a benign self-resolving skin lesion, ka is commonly treated as scc. biomarkers to distinguish ka and scc would thus be desirable. in search for specific markers, paraffin-embedded tissue samples from 25 scc and 64 ka were arranged in a tissue microarray (tma) and stained for immunologic cell-markers cd3, cd20 and cd68 as well as for proteins considered of relevance in tum ... | 2009 | 19165861 |
| triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the hpv test positivity rate. | consistent evidence underlines the utility of human papillomavirus (hpv) dna testing in the management of women with equivocal cervical cytological abnormalities, but not in case of low-grade lesions. we performed a meta-analysis including studies where the high-risk probe of the hybrid capture-ii is used to triage these two cytological categories. the triage test-positivity rate reflects the colposcopy referral workload.data were pooled on the hpv test positivity rate in women with atypical squ ... | 2009 | 19166485 |
| human papillomavirus negative but dyskaryotic cervical cytology: re-analysis of molecular testing. | evaluation of molecular human papillomavirus (hpv) testing into uk cervical screening programmes is underway. in south wales the current hpv prevalence in women attending routine screening is 13.5% with 76.3% hr hpv positive in cases with reported dyskaryotic cervical cytology [hibbitts s, jones j, powell n, dallimore n, mcrea j, beer h, et al. human papillomavirus prevalence in women attending routine cervical screening in south wales, uk: a cross-sectional study. br j cancer 2008;99(december ( ... | 2009 | 19264544 |
| increased risk of oncogenic human papillomavirus infections and incident high-grade cervical intraepithelial neoplasia among smokers: experience from the latin american screening study. | the purpose of this study was to assess the effect of smoking on the prevalence and incidence of high-risk human papillomavirus (hr-hpv) infection and cervical intraepithelial neoplasia (cin) in a large sample of latin american women. | 2009 | 19265732 |
| p16, ki-67, and bd proexc immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia. | p16, ki-67, and bd proexc (tripath imaging, inc., burlington, nc) have each been shown to be helpful adjuncts in the diagnosis and grading of human papillomavirus-associated cervical intraepithelial neoplasia. however, no clear guidelines are available regarding their use in routine practice. this study was designed to evaluate the efficacy of the 3 stains alone and in combinations to determine the most useful strategy in the diagnosis of cervical intraepithelial neoplasia and provide guidance i ... | 2009 | 19269017 |
| cervical cancer: physiology, risk factors, vaccination and treatment. | cervical cancer is the second most common female cancer after breast cancer. unlike many other cancers, however, it is largely preventable through screening and vaccination. therefore, it is necessary for nurses to educate women about cervical cancer, to have an awareness of the mortality rates associated with cervical cancer, and to promote the nhs cervical cancer screening programme. this article discusses the need for cervical screening and methods of prevention, identifies risk factors, trea ... | 2009 | 19270604 |
| human papillomavirus types by age in cervical cancer precursors: predominance of human papillomavirus 16 in young women. | in a population-based study conducted in guanacaste, costa rica, we investigated the human papillomavirus (hpv) types detected in 233 cases of cervical intraepithelial neoplasia (cin) 2/3 and cancer by age. cin2+ and cin3+ in young women were significantly more likely to be associated with hpv 16 than the same lesions in older women (80% of cin3+ were associated with hpv 16 among women ages 18-26 years compared with only 32% among women older than 55 years; ptrend=0.018). there were no differenc ... | 2009 | 19273486 |
| detection of oncogenic human papillomavirus and other predictors of anal high-grade dysplasia in men who have sex with men with abnormal cytology. | the incidence of anal high-grade dysplasia in men who have sex with men is increasing. anal cytology that shows atypical squamous cells of undetermined significance is common, nonspecific, and rarely predicts high-grade squamous intraepithelial lesion. we want to know whether hybrid-capture ii(r) testing for oncogenic human papillomavirus (human papillomavirus+) in men who have sex with men with atypical squamous cells of undetermined significance is beneficial and whether other predictors of hi ... | 2009 | 19273953 |
| mbl2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus-related cervical cancer. | we investigated whether there is a correlation between mbl2 polymorphisms and the host susceptibility to human papillomavirus (hpv) infection and cancer development. toward this end, we analyzed mbl2 exon 1 polymorphisms in 172 women infected by strains of hpv that are associated with high-risk of cervical cancer development (or "high-risk" hpv infection), 105 of whom had hpv-related squamous cell carcinoma of the cervix (scc), as well as 105 women not infected by hpv. we demonstrated an associa ... | 2009 | 19275921 |
| epidermodysplasia verruciform-like lesions in an hiv patient. | epidermodysplasia verruciformis (ev) is a rare disorder involving widespread infection with specific human papillomavirus types and characteristic clinical lesions that may resemble verruca plana, tinea versicolor, psoriasis, or seborrheic keratoses. the most common hpv types found in ev are 5, 8, 17, and 20. histopathologically, lesions demonstrate stereotypical enlarged keratinocytes in the upper epidermis with gray-blue cytoplasm, enlarged round nuclei with pale chromatin, and one or multiple ... | 2009 | 19281706 |
| cidofovir induces an increase in levels of low-risk and high-risk hpv e6. | cidofovir is a nucleoside analogue that is used off-license to treat recurrent respiratory papillomatosis (rrp) caused by hpv6/11. however, the effect of this drug upon low-risk hpv 6/11 gene expression is unknown. | 2009 | 19283851 |
| vulvar cancer in young women: demographic features and outcome evaluation. | the objective of the study was to identify prognostic and environmental factors associated with vulvar carcinoma in young women. | 2009 | 19286150 |
| assessment of human papillomavirus and epstein-barr virus in lung adenocarcinoma. | the association of human papillomavirus (hpv) and epstein-barr virus (ebv) infection with non-small cell lung cancer is controversial. hpv and ebv prevalence in a uniform population of lung adenocarcinoma was investigated, hypothesizing that there would be differences seen between smokers and non-smokers and between sexes. patients involved in this study were selected from a single institution database of lung cancer. in total 497 patients with adenocarcinoma were identified and 110 patients had ... | 2009 | 19287995 |
| one in four california adolescent girls have had human papillomavirus vaccination. | 2009 | 19288623 | |
| the evaluation of human papillomavirus genotyping in cervical liquid-based cytology specimens; using the roche linear array hpv genotyping assay. | to ascertain the usefulness of the roche linear array human papillomavirus (hpv) genotyping assay for assessing hpv genotypes in liquid-based cytology (lbc) samples and to evaluate this methodology within a cytopathology laboratory. these tests are of importance as persistent infection with high-risk hpv genotypes is considered a causal factor in the development of cervical cancer. | 2009 | 19291176 |
| human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients. | we investigated the role of human papillomavirus (hpv) in the development of transitional cell carcinoma (tcc) arising in renal transplant recipients. | 2009 | 19291536 |
| dutch public health experts refute claims that human papillomavirus vaccination has health risks. | 2009 | 19293220 | |
| endocervical adenocarcinomas with prominent endometrial or endomyometrial involvement simulating primary endometrial carcinomas: utility of hpv dna detection and immunohistochemical expression of p16 and hormone receptors to confirm the cervical origin of the corpus tumor. | determining the primary site of a uterine adenocarcinoma can be problematic in hysterectomy specimens due to the overlapping morphology of endocervical adenocarcinomas and endometrial carcinomas, particularly when both the corpus (usually lower uterine segment) and endocervix are involved and precursor lesions are lacking or difficult to distinguish from intramucosal spread of carcinoma from one site to the other. both preferential extension of endocervical adenocarcinomas into the endometrium ( ... | 2009 | 19295407 |
| five-year experience of human papillomavirus dna and papanicolaou test cotesting. | to estimate the 5-year age group-specific test positives for pap tests and human papillomavirus (hpv) testing in a large, general screening population of women 30 and older. | 2009 | 19300322 |
| central european vaccination advisory group (cevag) guidance statement on recommendations for the introduction of hpv vaccines. | vaccines against human papillomavirus (hpv), the primary causative agent in cervical cancer, are licensed. this paper contains the central european vaccination advisory group (cevag) guidance statement on the introduction of hpv vaccines in central europe. eight countries currently have medical representatives on cevag: the czech republic, estonia, hungary, lithuania, poland, romania, slovakia and turkey. by raising awareness and disseminating information, cevag aims to promote the efficient and ... | 2009 | 19301033 |
| genital and perianal herpes simplex simulating neoplasia in patients with aids. | genital and perianal herpetic ulcers are common in hiv-infected patients and chronic mucocutaneous ulcers persisting for more than 1 month are the hallmark of active aids status. however, atypical clinical manifestations of herpes simplex virus (hsv) may occur in immunocompromised patients presenting as tumor-like nodules or condylomatous or hypertrophic lesions, rather than a classic ulcer. such unusual presentations raise the risk of misdiagnosis and a delay in appropriate treatment. here we d ... | 2009 | 19302018 |
| occurrence of human papillomavirus in pterygia. | the aim of the study was to assess the occurrence of human papillomavirus (hpv) dna in pterygium. | 2009 | 19302081 |
| human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. | data on human papillomavirus (hpv) prevalence in vulvar and vaginal cancers are limited. these data are important to predict the potential future effect of prophylactic hpv vaccines. our aim was to conduct a systematic review of hpv type distribution in vulvar and vaginal invasive carcinomas, vulvar intraepithelial neoplasia (vin), and vaginal intraepithelial neoplasia. | 2009 | 19305339 |
| adolescent gynecology. | given new developments in the field of adolescent reproductive health, this review focuses on highlighting new guidelines and practice patterns in evaluation and management of adolescent gynecologic problems. first, understanding the proper techniques for the initial examination is key to establishing a long-term relationship with this age group. reservations about the first gynecologic examination are common, and the practitioner's goal is foremost to make the patient as comfortable as possible ... | 2009 | 19305342 |
| p21 cip1/waf1 expression is strongly associated with hpv-positive tonsillar carcinoma and a favorable prognosis. | human papillomavirus is involved in the carcinogenesis of tonsillar squamous cell carcinomas. here, we investigated the expression and the prognostic value of key cell cycle proteins in the prb and p53 pathways in both human papillomavirus type 16-positive and -negative tonsillar squamous cell carcinomas. using immunohistochemistry, 77 tonsillar squamous cell carcinomas with known human papillomavirus type 16 status and clinical outcome were analyzed for expression of ki67, p16(ink4a,) cyclin d1 ... | 2009 | 19305381 |
| [pathogenesis of human papillomavirus infection in patients with epidermodysplasia verruciformis]. | epidermodysplasia verruciformis (ev), a rare inherited disease, is believed to be associated with human papillomavirus (hpv) infection. ever1/2 genes, dendritic cells, t lymphocytes, and the biological characteristics of hpv itself may play roles in the pathogenesis of hpv infection. | 2009 | 19317070 |
| primary cervical cancer truly negative for high-risk human papillomavirus is a rare but distinct entity that can affect virgins and young adolescents. | cancer of the uterine cervix is almost exclusively associated with human papillomavirus (hpv). carcinogenesis is slow, the minimal time from initial hpv infection to invasive carcinoma seems to be less than ten years. in order to identify rapid onset cervical cancer, we carried out a retrospective re-analysis of an extended cohort of patients with invasive cervical cancer, and reviewed cases identified within the cancer registry of lower saxony or using medline or isi data. no instances of a rap ... | 2009 | 19317256 |
| prevalence of chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples. | the aim of the study was to evaluate the frequency of occurrence of hpv and co-infection: chlamydia (c.) trachomatis and hsv-2 in cervical cancer. | 2009 | 19317260 |
| multiple-type human papillomavirus infection in male anogenital sites: prevalence and associated factors. | human papillomavirus (hpv) causes cervical cancer and is strongly associated with other anogenital cancers. multiple-type hpv infection has been associated with lengthier infection and precancerous lesions. little is known about multiple-type hpv prevalence and associated factors in men. we examined the prevalence of and risk factors for multiple-type hpv in primarily asymptomatic men. detection of 37 hpv types in male anogenital epithelium and semen was completed in 463 men in two u.s. cities. ... | 2009 | 19318438 |
| human papillomavirus genotype distributions: implications for vaccination and cancer screening in the united states. | limited data are available describing human papillomavirus (hpv) genotype distributions in cervical cancer in the united states. such studies are needed to predict how hpv vaccination and hpv-based screening will influence cervical cancer prevention. | 2009 | 19318628 |
| assessing the hpv vaccine: researchers confront complex interplay of factors. | 2009 | 19318636 | |
| demographic and risk factors in patients with head and neck tumors. | the association between human papillomavirus (hpv) infection and the development of head and neck cancer has been documented recently. in this study on 86 head and neck cancer patients and 124 controls, data regarding demographics, behavioral risk factors, and risks related to hpv exposure were collected. hpv detection was carried out using polymerase chain reaction in the tumors and in oral exfoliated cells, and hpv typing by a reverse line blot assay specific for 37 hpv types. sera were tested ... | 2009 | 19319944 |
| [human papillomavirus vaccination in denmark]. | 2009 | 19321083 | |
| male circumcision for the prevention of hsv-2 and hpv infections and syphilis. | male circumcision significantly reduced the incidence of human immunodeficiency virus (hiv) infection among men in three clinical trials. we assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) infections and syphilis in hiv-negative adolescent boys and men. | 2009 | 19321868 |
| [pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. | to further understand the clinicopathological, ultrastructural and molecular features of penile pseudoangiosarcomatous squamous cell carcinoma (pascc), and improve its diagnosis and treatment. | 2009 | 19323373 |
| novel anti-metastatic action of cidofovir mediated by inhibition of e6/e7, cxcr4 and rho/rock signaling in hpv tumor cells. | cervical cancer is frequently associated with hpv infection. the expression of e6 and e7 hpv oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. the cellular mechanisms involved in metastatic spread remain elusive, but pro-adhesive receptors and their ligands, such as sdf-1alpha and cxcr4 are implicated. in the present study, we assessed the possible relationship between sdf-1alpha/cxcr4 signaling, e6/e7 status and the meta ... | 2009 | 19325708 |
| cancer risk in persons with hiv/aids in india: a review and future directions for research. | india has a large and evolving hiv epidemic. little is known about cancer risk in indian persons with hiv/aids (pha) but risk is thought to be low. | 2009 | 19327166 |
| infectious complications in three double hand recipients: experience from a single center. | composite tissue allograft (cta) recipients require high level of immunosuppression and, therefore, are at significant risk to acquire opportunistic infections. | 2009 | 19328916 |
| incidence of human papillomavirus (hpv) positive tonsillar carcinoma in stockholm, sweden: an epidemic of viral-induced carcinoma? | in the county of stockholm, between 1970 and 2002, we have previously reported a 3-fold parallel increase in the incidence of tonsillar squamous cell carcinoma (scc) and the proportion of human papillomavirus (hpv) positive tonsillar scc. here, we have followed the above parameters in all patients (n = 120) diagnosed with tonsillar scc during 2003-2007 in the same area, and also in correlation to our previous data. ninety-eight pretreatment biopsies were available and presence of hpv dna and hpv ... | 2009 | 19330833 |
| galectin-3 overexpression in invasive laryngeal carcinoma, assessed by computer-assisted analysis. | the larynx is the most common site of malignancy in the upper aerodigestive tract. in brazil, malignant laryngeal lesions represent 2% of all cancers, with approximately 3000 annual deaths. the association between human papillomavirus (hpv) and laryngeal cancer is still controversial. the aim of the present retrospective study was to determine the expression of galectin-3 immunoperoxidase in laryngeal carcinoma by examining paraffin-embedded larynx biopsies from 65 patients, 10 in situ laryngeal ... | 2009 | 19332433 |
| cervical carcinoma and sexual behavior: collaborative reanalysis of individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical carcinoma from 21 epidemiological studies. | high-risk human papillomavirus (hpv) types cause most cervical carcinomas and are sexually transmitted. sexual behavior therefore affects hpv exposure and its cancer sequelae. the international collaboration of epidemiological studies of cervical cancer has combined data on lifetime number of sexual partners and age at first sexual intercourse from 21 studies, or groups of studies, including 10,773 women with invasive cervical carcinoma, 4,688 women with cervical intraepithelial neoplasia grade ... | 2009 | 19336546 |
| [polish gynaecological society guidelines for human papilloma virus (hpv) vaccination]. | 2009 | 19338212 | |
| human papillomavirus-related disease in people with hiv. | the incidence of human papillomavirus (hpv)-related cancers has increased among people with hiv infection compared with the general population. this review will describe recent findings in hpv-associated cancer incidence since the introduction of antiretroviral therapy, hpv/disease prevalence at sites other than cervix and anus, and recent data on screening and treatment of anal intraepithelial neoplasia. | 2009 | 19339939 |
| somatic lkb1 mutations promote cervical cancer progression. | human papilloma virus (hpv) is the etiologic agent for cervical cancer. yet, infection with hpv is not sufficient to cause cervical cancer, because most infected women develop transient epithelial dysplasias that spontaneously regress. progression to invasive cancer has been attributed to diverse host factors such as immune or hormonal status, as no recurrent genetic alterations have been identified in cervical cancers. thus, the pressing question as to the biological basis of cervical cancer pr ... | 2009 | 19340305 |
| a highly efficient system to produce infectious human papillomavirus: elucidation of natural virus-host interactions. | a simple, efficient system has been developed to produce high titers of infectious human papillomavirus type 18 (hpv-18) in organotypic raft cultures of primary human keratinocytes (phks). molecular characterization elucidated key early and late events in the reproductive program. the system obviates the need for immortalized cells and allows the analyses of mutant hpv genomes not previously possible. an e6 deletion mutant incapable of causing p53 degradation is defective in viral dna amplificat ... | 2009 | 19342877 |
| anal cancer screening in men who have sex with men. | to determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. | 2009 | 19343830 |
| role of human papillomavirus in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | in this study, we aimed to evaluate the role of human papillomavirus (hpv) in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | 2009 | 19344621 |
| the epidemiology of anal human papillomavirus and related neoplasia. | the relationship between cervical cancer and human papillomavirus (hpv) is well known. like cervical cancer, anal cancer is preceded by a series of precancerous changes, raising the possibility that like cervical cancer, anal cancer can be prevented. further, given the known risk factors for anal cancer, prevention efforts could be targeted to high-risk groups, providing a unique example of a screening program targeted to high-risk individuals. this article describes the epidemiology of anal hpv ... | 2009 | 19344856 |
| mechanisms of decreased expression of transforming growth factor-beta receptor type i at late stages of hpv16-mediated transformation. | transforming growth factor-beta (tgf-beta) signaling is disrupted in many cancers, including cervical cancer, leading to tgf-beta resistance. although initially sensitive, human papillomavirus type 16 (hpv16) immortalized human keratinocytes (hkc/hpv16) become increasingly resistant to the growth inhibitory effects of tgf-beta during in vitro progression to a differentiation resistant phenotype (hkc/dr). we have previously shown that loss of tgf-beta sensitivity in hkc/dr is attributed to decrea ... | 2009 | 19344999 |
| adolescent girls' attitudes on human papillomavirus vaccination. | the objective of the study was to assess the attitudes of adolescent girls on human papillomavirus (hpv) vaccination and the impact of an information pamphlet on their attitude. other factors that may affect their attitude were also studied. | 2009 | 19345913 |
| genetic variation in the vitamin c transporter, slc23a2, modifies the risk of hpv16-associated head and neck cancer. | human papillomavirus (hpv) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (hnscc). it is unknown if host genetic susceptibility modifies the hpv16-hnscc association. dna samples collected as part of a boston area case-control study of hnscc were genotyped for single-nucleotide polymorphisms (snps) from the national cancer institute's snp500cancer database. analysis of demographic, phenotypic and genotypic data for 319 hnscc cases and 495 frequency- ... | 2009 | 19346260 |
| role of molecular markers and gene profiling in head and neck cancers. | to explore the current status of molecular markers in the diagnosis, prognosis, and treatment of squamous cell carcinoma of the head and neck. | 2009 | 19346943 |
| geographic variation in the prevalence of kaposi sarcoma-associated herpesvirus and risk factors for transmission. | the aim of the present study was to estimate the prevalence of kaposi sarcoma-associated herpesvirus (kshv) in the female general population, to define geographic variation in and heterosexual transmission of the virus. | 2009 | 19351262 |
| cost-effectiveness evaluation of a quadrivalent human papillomavirus vaccine in belgium. | the introduction of a quadrivalent human papillomavirus (hpv; types 6, 11, 16, 18) vaccine is expected to significantly reduce the burden of cervical cancer, cervical intraepithelial neoplasia (cin), genital warts and other hpv-related diseases. | 2009 | 19354343 |
| molecular tests for human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cytology specimen. | laboratory detection of human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cervicovaginal cytology specimens is now based on identification of the dna sequences unique to these infectious agents. however, current commercial test kits rely on nucleotide probe hybridization to determine dna sequences, which may lead to diagnostic errors due to cross-reactivity. the aim of this study was to find a practical approach to perform automated sanger dna sequencing ... | 2009 | 19358733 |
| human papillomavirus 58 in a squamous cell carcinoma of the tongue. | 2009 | 19362048 | |
| cost-effectiveness of human papillomavirus vaccination in belgium: do not forget about cervical cancer screening. | the cost-effectiveness of adding a human papillomavirus (hpv) vaccination program in 12-year-old females to the recommended cervical cancer screening in belgium is examined. moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a hpv vaccination program are investigated. | 2009 | 19366497 |
| potent anti-hpv immune responses induced by tandem repeats of the hpv16 l2 (20 -- 38) peptide displayed on bacterial thioredoxin. | the minor capsid protein l2 is a promising candidate for the construction of an anti-human papillomavirus (hpv) broadly protective vaccine for the prophylaxis of cervical cancer. however, l2-derived peptides are usually poorly immunogenic and extensive knowledge on the most relevant (cross)neutralizing epitope(s) is still needed. we systematically examined the immunogenicity and virus neutralization potential of six peptides encompassing the n-terminal (amino acids 1 -- 120) region of hpv16 l2 ( ... | 2009 | 19368776 |
| usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. | to date, there is no reliable immunohistochemical marker that discriminates between primary pulmonary squamous cell carcinoma (scc) and cervical scc metastatic to the lung. in this study, immunohistochemical staining of p16 was performed on 33 primary pulmonary sccs, 48 primary cervical sccs, and 17 cases of cervical scc with pulmonary metastasis. expression of p16 was noted in 47 cases of cervical scc (47/48 [98%]), and all were strongly stained. of the 7 cases of primary pulmonary scc (7/33 [2 ... | 2009 | 19369633 |
| papanicolaou screening behavior in mothers and human papillomavirus vaccine uptake in adolescent girls. | we investigated whether maternal attitude toward prevention, as indicated by history of seeking papanicolaou (pap) tests and contracting sexually transmitted infections, influenced human papillomavirus (hpv) vaccine uptake among their adolescent daughters. | 2009 | 19372507 |
| p16 ink4a is a strong biomarker for cervical intraepithelial neoplasia and invasive cervical carcinoma: a reappraisal. | to assess the role of p16( ink4a), bcl-2, and p53 in cervical cancer screening, we conducted a retrospective trial of prospectively collected data. sixty two women with abnormal pap smears were subjected to colposcopy and biopsies from any abnormal lesion. human papillomavirus (hpv)-dna typing, histology, and immunochemistry for p16(ink4a), bcl-2, and p53 were performed for these women. histologic diagnosis was that of low grade squamous intraepithelial lesion (lsil), high grade squamous intraep ... | 2009 | 19372590 |
| prognostic value of measuring load of human papillomavirus dna in cervical samples: an elusive target. | 2009 | 19176455 | |
| [mechanisms of high-risk human papillomavirus-induced cervical carcinogenesis]. | human papillomaviruses (hpvs) are believed to be the primary causal agents for development of pre-neoplastic and malignant lesions of the uterine cervix and high-risk types such as type 16 and 18 are associated with more than 90% of all cervical carcinomas. the e6 and e7 genes of hpvs are thought to play causative roles, since e6 promotes the degradation of p53 through its interaction with e6ap, an e3 ubiquitin ligase, whereas e7 binds to the retinoblastoma protein prb and disrupts its complex f ... | 2009 | 19177752 |
| [advancements in diagnosis of sexually transmitted diseases in urology]. | sexually transmitted diseases diagnosed and treated exclusively in urology clinics are male urethritis and epididymitis caused by neisseria gonorrhoeae and chlamydia trachomatis. although recent developments in diagnostic tools have made it possible to detect these microorganisms with extremely high sensitivities, the screening of neisseria gonorrhoeae using the microscopic observation of intraleucocyte diplococci stained by methylene blue or gram staining in the first voided urine sediment or u ... | 2009 | 19177755 |
| epithelial expression of human papillomavirus type 16 e7 protein results in peripheral cd8 t-cell suppression mediated by cd4+cd25+ t cells. | the role of thymic versus peripheral epithelium in the regulation of the antigen-specific cd8 t-cell repertoire is still largely unresolved. we generated tcr-beta chain transgenic mice in which an increased frequency of peripheral cd8 t cells recognizes an epitope from a viral oncoprotein (hpv16e7) in the context of h-2d(b) mhc class i. when t cells from these mice developed through the thymus of mice expressing functional e7 protein from a keratin 14 promoter, no major perturbation to transgeni ... | 2009 | 19180468 |
| multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions. | to evaluate the effect of multiple human papillomavirus (hpv) infection on the prevalence of cervical intraepithelial neoplasia (cin) among women undergoing colposcopy following a cytological diagnosis of atypical squamous cells of undetermined significance (ascus) or low grade squamous intraepithelial lesions (lsil). | 2009 | 19181368 |
| immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells. | most in vitro studies of oral carcinogenesis in human cells are carried out with oral keratinocytes immortalized by human papillomavirus type 16 dna. however, because various etiological factors for oral cancer are known, it is important to establish new human keratinocyte cell lines useful for studying the mechanism of oral carcinogenesis. normal human gingival keratinocytes in secondary cultures grown in serum-free medium were either transfected with origin (-) sv40 dna or sequentially transfe ... | 2009 | 19184294 |
| ensembled support vector machines for human papillomavirus risk type prediction from protein secondary structures. | infection by the human papillomavirus (hpv) is regarded as the major risk factor in the development of cervical cancer. detection of high-risk hpv is important for understanding its oncogenic mechanisms and for developing novel clinical tools for its diagnosis, treatment, and prevention. several methods are available to predict the risk types for hpv protein sequences. nevertheless, no tools can achieve a universally good performance for all domains, including hpv and nor do they provide confide ... | 2009 | 19185855 |
| genetic variants in tap are associated with high-grade cervical neoplasia. | the transporter associated with antigen processing (tap) is essential in assembling mhc-i proteins. human papillomavirus (hpv) evades immune recognition by decreasing class i mhc cell surface expression through down-regulation of tap1 levels. consistent with heterogeneity in mhc expression is the individual variability in clearing detectable hpv infections. genetic polymorphisms in tap genes may affect protein structure, function, and the ability to clear hpv infection. | 2009 | 19188174 |
| human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. | a systematic review was conducted of hpv type distribution in anal cancer and anal high-grade and low-grade squamous intraepithelial lesions (hsil and lsil). a medline search of studies using pcr or hybrid capture for hpv dna detection was completed. a total of 1,824 cases were included: 992 invasive anal cancers, 472 hsil cases and 360 lsil cases. crude hpv prevalence in anal cancer, hsil, and lsil was 71, 91 and 88%, respectively. hpv16/18 prevalence was 72% in invasive anal cancer, 69% in hsi ... | 2009 | 19189402 |
| disparities in how parents are learning about the human papillomavirus vaccine. | differential access to basic health information may contribute to persistent cervical cancer disparities. we examined whether human papillomavirus (hpv) vaccine awareness, hpv knowledge, and use of information sources about the vaccine differ by sociodemographic characteristics associated with cervical cancer. | 2009 | 19190161 |
| [human papillomavirus and cancer of the oropharynx. molecular interaction and clinical implications]. | one-third of the cases of oropharyngeal squamous cell carcinoma (oscc) contain oncogenic human papillomavirus (hr-hpv). epidemiologic and molecular evidence underlines the causal role of hr-hpv in these tumors, which can be defined as hpv-related oscc. these tumors differ from chemical/toxin-induced oscc in several biological aspects, including specific molecular and genetic alterations. this leads to a characteristic clinical profile of hpv-related oscc. sexual risk factors play a role; however ... | 2009 | 19194683 |
| [assessing the incidence of papillomavirus infections in france]. | high-risk oncogenic human papillomavirus (hr-hpv) are strongly associated with squamous cell carcinoma and adenocarcinoma of the uterine cervix. relatively detailed data on prevalence of hr-hpv infections by age in france are available in several cytologically normal women populations but none on incidence. these latter data may be obtained according to the relationship between prevalence and incidence due to the spontaneous viral clearance over time. the study has shown that hr-hpv infections i ... | 2009 | 19196534 |
| human papillomavirus-associated squamous cell carcinoma of the nail bed in african-american patients. | human papillomavirus (hpv) has been implicated in the development of digital squamous cell carcinoma (scc). case reports in the literature mostly identify hpv type 16 present in tumors, but hpv types 2, 31, 34, 35, and 73 have also been isolated. | 2009 | 19200182 |
| an e7-based therapeutic vaccine protects mice against hpv16 associated cancer. | plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. we evaluated the anti-tumour activity of a nicotiana benthamiana produced vaccine candidate based on the non-transforming e7 protein of hpv-16 fused to beta-1,3-1,4-glucanase of clostridium thermocellum. two doses of vaccine at two week intervals were administered to groups of c57bl/6 mice starting 3 or 6 days after challenge with tumourigenic e7-expressing tc-1* ... | 2009 | 19200826 |
| prophylactic hpv vaccination for women over 18 years of age. | cervical screening has resulted in a major reduction in the incidence and mortality of cervical cancer in the uk and other developed countries. nevertheless approximately 2700 women present with cervical cancer in the uk each year with mortality in excess of 1000 cases. prophylactic hpv vaccination against hpv 16 and 18 has been shown to be highly effective in preventing hpv related malignancy in clinical trials. newly introduced hpv vaccination programmes in the uk and elsewhere are ultimately ... | 2009 | 19200838 |
| vaginal self-swab specimen collection in a home-based survey of older women: methods and applications. | to describe the methods used for, cooperation with, assays conducted on, and applications of vaginal specimens collected by older women in their homes. | 2009 | 19204072 |
| high-risk and multiple human papillomavirus (hpv) infections in cancer-free jamaican women. | vaccines, that target human papillomavirus (hpv) high risk genotypes 16 and 18, have recently been developed. this study was aimed at determining genotypes commonly found in high-risk and multiple-hpv infections in jamaican women. two hundred and fifty three (253) women were enrolled in the study. of these, 120 pregnant women, aged 15-44 years, were recruited from the ante natal clinic at the university hospital of the west indies and 116 non-pregnant, aged 19-83, from a family practice in weste ... | 2009 | 19208202 |
| comparisons of high-risk cervical hpv infections in caribbean and us populations. | disparities in cervical cancer incidence and mortality rates exist among women of african ancestry (african-american, african-caribbean and african). persistent cervical infection with human papillomavirus (hpv) is associated with cervical dysplasia and if untreated, could potentially progress to invasive cervical cancer. very few studies have been conducted to examine the true prevalence of hpv infection in this population. comparisons of cervical hpv infection and the type-specific distributio ... | 2009 | 19208214 |
| statbite: prevalence of hpv in a cohort of u.s. men. | 2009 | 19211451 | |
| cellular growth inhibition by fk778 is linked to g1 arrest or s phase accumulation, dependent on the functional status of the retinoblastoma protein. | the malononitrilamide fk778 is a novel immunosuppressive agent with antiproliferative activities. to gain insight into the molecular mechanism of fk778-mediated growth inhibition, we analyzed cells which differ in their p53 status and functionality of retinoblastoma protein (prb). fk778 acted as a broad inhibitor of cell proliferation independent of the p53 or prb status. however, the mechanism of fk778-mediated growth inhibition differed, leading either to cell cycle arrest in g1, or cell accum ... | 2009 | 19212661 |
| cancer prevention by vaccination against hepatitis b. | chronic inflammation caused by persistent infection is closely related to a number of cancers; these include hepatitis b (hbv) or c and hepatoma, human papilloma virus and cervical cancer, and helicobacter pylori and gastric cancer. the first evidence of cancer prevention by vaccination in humans was provided by hbv vaccination in infants. chronic hbv is related to approximately 60%-90% of hepatocellular carcinomas (hcc) in adults and nearly 100% of childhood hcc in areas endemic for hbv infecti ... | 2009 | 19213561 |
| human papillomaviruses and genital co-infections in gynaecological outpatients. | high grade hpv infections and persistence are the strongest risk factors for cervical cancer. nevertheless other genital microorganisms may be involved in the progression of hpv associated lesions. | 2009 | 19216747 |
| surgical salvage of cancer of the oropharynx after chemoradiation. | advanced oropharyngeal squamous cell carcinoma is treated primarily with chemoradiation, with the goal of excellent disease control and preservation of swallowing and articulation functions of the oropharynx. disease control rates generally are excellent; however, a significant number of patients do not achieve locoregional control of disease. the importance of human papillomavirus expression in predicting successful tumor response, locoregional control, and survival following chemoradiation is ... | 2009 | 19216847 |
| genetic signatures of hpv-related and unrelated oropharyngeal carcinoma and their prognostic implications. | patients with human papillomavirus (hpv)-containing oropharyngeal squamous cell carcinomas (oscc) have a better prognosis than patients with hpv-negative oscc. this may be attributed to different genetic pathways promoting cancer. | 2009 | 19223504 |
| knowledge and awareness of cervical cancer and screening among malaysian women who have never had a pap smear: a qualitative study. | cervical cancer is one of the commonest cancers in women worldwide. despite the existence of effective screening using pap smear, the uptake of screening is poor. a qualitative study was undertaken using face-to-face in-depth interviews to investigate knowledge, attitudes and beliefs on cervical cancer screening of malaysian women. | 2009 | 19224084 |