Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| coinfections with influenza virus and atypical bacteria: implications for severe outcomes? | 2016 | 27249224 | |
| oral administration of recombinant mycobacterium smegmatis expressing a tripeptide construct derived from endogenous and microbial antigens prevents atherosclerosis in apoe(-/-) mice. | immunotherapy by inducing oral tolerance to atherogenic self-antigens is gaining importance as an alternative treatment modality for atherosclerosis. the use of live bacterial vectors to express the recombinant antigen in vivo will obviate the need for large-scale purification of recombinant protein and may also augment the efficacy of oral tolerance induction. | 2016 | 27241889 |
| the prevalence of chlamydia pneumoniae in the aortic wall and in peripheral blood of patients scheduled for coronary artery bypass grafting. | some reports confirm a potential role of chlamydia pneumoniae (chp) in atherogenesis. in order to explore possible association between chp and atherosclerosis, investigations were carried out in which the frequency of chp in the arterial wall and peripheral blood was assessed in a group of patients with chronic coronary artery disease (cad). fifty-seven patients were enrolled in the study, 13 women and 44 men aged 61.8±6.5 (47-74), with previously diagnosed cad, scheduled for planned coronary ar ... | 2016 | 27358129 |
| prevalence of pulmonary infections caused by atypical pathogens in non-hiv immunocompromised patients. | although atypical bacteria are important causes of lower airway infections, data on their role in immunocompromised patients are scarce. the aim of the study was to evaluate the prevalence of atypical pulmonary infections in patients with various types of immunosuppression, and to analyze clinical characteristics of these infections. eighty non-hiv immunocompromised patients with different underlying diseases and clinical and radiological signs of pulmonary infection were enrolled. due to incomp ... | 2016 | 27334731 |
| signaling events in pathogen-induced macrophage foam cell formation. | macrophage foam cell formation is a key event in atherosclerosis. several triggers induce low-density lipoprotein (ldl) uptake by macrophages to create foam cells, including infections with porphyromonas gingivalis and chlamydia pneumoniae, two pathogens that have been linked to atherosclerosis. while gene regulation during foam cell formation has been examined, comparative investigations to identify shared and specific pathogen-elicited molecular events relevant to foam cell formation are not w ... | 2016 | 27481727 |
| [community acquired pneumonia - treatment options according to the international recommendations]. | pneumonia remains one of the main reasons of heath care system utilization. quick diagnosis and prompt treatment initiation determine favorable outcome. empirical antibiotic treatment allows to achieve treatment success in most patients. treatment recommendations are based on big epidemiological trials. nevertheless, it is sometimes necessary to know the definite etiologic factor of pneumonia. in these cases microbiological diagnostics is useful, i.e. sputum microscopy and culture, blood culture ... | 2016 | 27421128 |
| [distribution characteristics of mycoplasma pneumoniae, chlamydia pneumoniae, and legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases]. | to investigate the distribution characteristics of mycoplasma pneumoniae (mp), chlamydia pneumoniae (cp), and legionella pneumophila (lp) in hospitalized children with acute respiratory tract infection (arti). | 2016 | 27412543 |
| chronic infection and severe asthma. | chronic bacterial infection is implicated in both the development and severity of asthma. the atypical bacteria mycoplasma pneumoniae and chlamydophila pneumoniae have been identified in the airways of asthmatics and correlated with clinical features such as adult onset, exacerbation risks, steroid sensitivity, and symptom control. asthmatic patients with evidence of bacterial infection may benefit from antibiotic treatment directed towards these atypical organisms. examination of the airway mic ... | 2016 | 27401621 |
| prevalence and seasonal distribution of respiratory viruses during the 2014 - 2015 season in istanbul. | acute respiratory tract infection (arti) is one of the most common infections worldwide, causing significant morbidity and mortality. | 2016 | 27800148 |
| comparison of serological methods with pcr-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria. | the diagnosis of community-acquired pneumonia (cap) caused by legionella pneumophila, mycoplasma pneumoniae, and chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requirements, are time-consuming, and offer delayed results that limit their clinical usefulness of these techniques. we sought to develop a multiplex pcr (mpcr) method to diagnosis these bacterial infections in cap patients and to compare the diagnostic yields obtained from mpcr of nasopharyn ... | 2016 | 26932735 |
| is there any association between sarcoidosis and infectious agents?: a systematic review and meta-analysis. | during the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. with the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. | 2016 | 27894280 |
| coinfection of chlamydiae and other bacteria in reactive arthritis and spondyloarthritis: need for future research. | reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen chlamydia trachomatis in some individuals. recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen chlamydia pneumoniae, can elicit a similar arthritis. studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. howev ... | 2016 | 27681924 |
| common mechanisms involved in alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation. | strong epidemiologic evidence and common molecular mechanisms support an association between alzheimer's disease (ad) and type 2-diabetes. local inflammation and amyloidosis occur in both diseases and are associated with periodontitis and various infectious agents. this article reviews the evidence for the presence of local inflammation and bacteria in type 2 diabetes and discusses host pathogen interactions in chronic inflammatory disorders. chlamydophyla pneumoniae, helicobacter pylori and spi ... | 2016 | 26961231 |
| [importance of respiratory virus in immunocompetent adult patients hospitalized with community-acquired pneumonia]. | community-acquired pneumonia (cap) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. | 2016 | 28393985 |
| [bronchopulmonary infections caused by atypical pathogens in children : myth or reality?] | mycoplasma pneumoniae and chlamydia pneumoniae are the most common atypical pathogens seen in respiratory infections in children. currently, the management of atypical pneumonia due to these pathogens is blurry. the clinical features are hardly specific ; it appears that m. pneumoniae respiratory infect ions are associated with chest pain and the absence of wheezing, however, further confirmations are needed. hoarseness is frequently seen with c. pneumoniae infection. co-infections with viruses, ... | 2016 | 28525234 |
| dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with henoch-schönlein purpura. | henoch-schönlein purpura (hsp) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of iga immune complexes. an association between hsp and atypical bacteria is uncommon in children. | 2017 | 29097818 |
| the association between serological features of chronic chlamydia pneumoniae infection and markers of systemic inflammation and nutrition in copd patients. | chlamydia pneumoniae is an obligatory human pathogen involved in lower and upper airway infections, including pneumonia, bronchitis. asymptomatic c. pneumoniae carriage is also relatively common. the association of c. pneumoniae infections with the chronic obstructive pulmonary disease (copd) course is unclear. | 2017 | 29069917 |
| serological analysis and drug resistance of chlamydia pneumoniae and mycoplasma pneumoniae in 4500 healthy subjects in shenzhen, china. | to understand the prevalence and distribution of chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) in the population and to provide a basis for the prevention and treatment of respiratory tract infection. | 2017 | 29057257 |
| identification of privileged antichlamydial natural products by a ligand-based strategy. | the obligate intracellular pathogen chlamydia pneumoniae remains a difficult target for antimicrobial therapy. owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well as the propensity of the bacterium for persistent infections, treatment failures are common. despite the urgent need for new antichlamydial compounds, their discovery is challenged by the technically demanding assay procedures and lack of validated targets. an alternative strategy of using natural ... | 2017 | 29043803 |
| presence of atopy increases the risk of asthma relapse. | to describe the point prevalence of respiratory viruses/atypical bacteria using pcr and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations. | 2017 | 29021189 |
| infections and chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes. | thrombolysis is effective in ischemic stroke patients, but some factors influence its benefit. previous infections could increase the risk of ischemic stroke by an activation of systemic inflammation. we analysed the influence of previous infections and chlamydia pneumoniae serology on functional outcome in thrombolysed stroke patients. | 2017 | 28991723 |
| chlamydia pneumoniae inclusion membrane protein cpn0147 interacts with host protein creb3. | chlamydiae are gram-negative obligate intracellular bacteria that cause diseases with significant medical and economic impacts. like other chlamydial species, chlamydia pneumoniae possesses a unique developmental cycle, the infectious elementary body gains access to the susceptible host cell, where it transforms into the replicative reticulate body. the cytoplasmic vacuole where chlamydia pneumoniae replicates is called an inclusion, which is extensively modified by the insertion of chlamydial e ... | 2017 | 28957394 |
| interactions of antisera to different chlamydia and chlamydophila species with the ribosomal protein rps27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line. | chlamydia trachomatis (ct) and the chlamydophila species (cs) chlamydophila pneumoniae (cpn), and chlamydophila psittaci (cps) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (sle). the aim of the present study was therefore to identify cellular protein interaction partners with antisera to ct (α-ct) or cs (α-cs) and to identify functional consequences of such interaction in vitro. as detected with ... | 2017 | 28913776 |
| detection of specific chlamydia pneumoniae and cytomegalovirus antigens in human carotid atherosclerotic plaque in a chinese population. | to explore the relationship between certain pathogens, such as chlamydia pneumonia (cpn) and cytomegalovirus (cmv), and carotid atherosclerosis (as) in a chinese population.twenty-five carotid atherosclerotic stenosis patients from the beijing tiantan hospital (affiliated with capital medical university) participated in the study. after undergoing digital subtraction angiography (dsa) and/or computed tomography angiography (cta), the degree of carotid artery stenosis was over 70% in all cases, a ... | 2017 | 28903431 |
| atypical bacterial etiology of acute respiratory infections and clinical characterizations among iranian children. | acute respiratory infections (aris) in children younger than 5 years of age are one of the leading causes of morbidity and mortality, particularly in developing countries. mycoplasma pneumoniae and chlamydophila pneumoniae are prevalent causative agents of aris, worldwide. we sought m. pneumoniae and c. pneumoniae in respiratory samples from iranian children with aris. from november 2014 to april 2015, respiratory samples of 150 children aged 1 month to 15 years old were screened for presence o ... | 2017 | 28886324 |
| the impact of pathogen burden on leukocyte telomere length in the multi-ethnic study of atherosclerosis. | several infections have been linked to telomere shortening and in some cases these associations have varied by sex. we assessed the association between seropositivity to four persistent pathogens (cytomegalovirus (cmv), herpes simplex virus-1, helicobacter pylori, chlamydia pneumoniae), and total pathogen burden on leukocyte telomere length in a diverse us sample. data came from the multi-ethnic study of atherosclerosis, a population-based cohort study. we utilized cross-sectional survey data, a ... | 2017 | 28879822 |
| investigation of chlamydia pneumoniae infection in moroccan patients suffering from cardiovascular diseases. | chlamydia pneumoniae is an intracellular bacterium responsible for respiratory diseases and is highly involved in cardiovascular disease development, mainly atherosclerosis. the main objective of our study was to evaluate c. pneumoniae prevalence in moroccan patients suffering from cardiovascular diseases. a total of 115 patients with cardiovascular diseases were enrolled, and their clinical and behavioral information was recorded. blood was sampled from all patients as well as the atheroma plaq ... | 2017 | 28869155 |
| antimicrobial activity of bitespiramycin, a new genetically engineered macrolide. | the antimicrobial activity of bitespiramycin (bt) against chlamydia trachomatis (ct), chlamydia pneumoniae (cp), ureaplasma urealyticum (uu), and mycoplasma pneumoniae (mp), was compared with those of azithromycin (azm) and acetylspiramycin (at-sp) in vitro. furthermore, the anti-mp activities of bt and azm were evaluated in a hamster model. the activities of bt in vitro were similar to those of azm but were more effective than those of at-sp. bt effectively inhibited mp infection at a dose of 2 ... | 2017 | 28867456 |
| the etiology of community-acquired pneumonia among children under 5 years of age in mainland china, 2001-2015: a systematic review. | the aim of this systematic review was to examine the etiology of community-acquired pneumonia (cap) among chinese children younger than 5 years and provide evidence for further cost-effectiveness analyses for vaccine development, diagnostic strategies and empirical treatments. | 2017 | 28922613 |
| growth of chlamydia pneumoniae is enhanced in cells with impaired mitochondrial function. | effective growth and replication of obligate intracellular pathogens depend on host cell metabolism. how this is connected to host cell mitochondrial function has not been studied so far. recent studies suggest that growth of intracellular bacteria such as chlamydia pneumoniae is enhanced in a low oxygen environment, arguing for a particular mechanistic role of the mitochondrial respiration in controlling intracellular progeny. metabolic changes in c. pneumoniae infected epithelial cells were an ... | 2017 | 29259924 |
| multicenter evaluation of the eplex® respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs. | background: the performance of the new eplex® respiratory pathogen (rp) panel (genmark diagnostics) for the simultaneous detection of 19 viruses (influenza a, influenza a h1, influenza a 2009 h1, influenza a h3, influenza b, adenovirus, coronaviruses [hku1, oc43, nl63, 229e], human rhinovirus/enterovirus, human metapneumovirus, parainfluenza viruses 1, 2, 3 and 4, respiratory syncytial virus (rsv) [rsva and rsv b]) and two bacteria (mycoplasma pneumoniae and chlamydia pneumoniae) was evaluated.m ... | 2017 | 29212701 |
| molecular etiological profile of atypical bacterial pathogens, viruses and coinfections among infants and children with community acquired pneumonia admitted to a national hospital in lima, peru. | the main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (mycoplasma pneumoniae, chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (cap) from lima, peru. | 2017 | 29208015 |
| frequency of detection of chlamydophila pneumoniae using bronchoalveolar lavage fluid in patients with community-onset pneumonia. | chlamydophila pneumoniae is a causative pathogen of lower respiratory tract infection, which generally infects healthy, young people. however, it is often difficult to evaluate acute c. pneumoniae infection using upper respiratory tract specimens and/or sputum samples due to its persistent infection or colonization. the interpretation of frequency of detection of c. pneumoniae seems to be insufficient in community-onset pneumonia. the aim of this study was to evaluate the presence of c. pneumoni ... | 2017 | 29153416 |
| atypical bacterial pneumonia in the hiv-infected population. | human immunodeficiency virus (hiv)-infected individuals are more susceptible to respiratory tract infections by other infectious agents (viruses, bacteria, parasites, and fungi) as their disease progresses to acquired immunodeficiency syndrome. despite effective antiretroviral therapy, bacterial pneumonia (the most frequently occurring hiv-associated pulmonary illness) remains a common cause of morbidity and mortality in the hiv-infected population. over the last few decades, studies have looked ... | 2017 | 28856082 |
| acquisition of rab11 and rab11-fip2-a novel strategy for chlamydia pneumoniae early survival. | the initial steps in chlamydial infection involve adhesion and internalization into host cells and, most importantly, modification of the nascent inclusion to establish the intracellular niche. here, we show that chlamydia pneumoniae enters host cells via egfr-dependent endocytosis into an early endosome with a phosphatidylinositol 3-phosphate (pi3p) membrane identity. immediately after entry, the early chlamydial inclusion acquires early endosomal rab gtpases including rab4, rab5, rab7, as well ... | 2017 | 28787457 |
| elevated sodium leads to the increased expression of hsp60 and induces apoptosis in huvecs. | atherosclerosis is the leading cause of death in the world. we have previously shown that expression of heat shock protein 60 (hsp60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a t cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipop ... | 2017 | 28604836 |
| macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point. | therapy directed against atypical pathogens in patients with community-acquired pneumonia (cap) is often recommended. this post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment in atypical cap. | 2017 | 28599867 |
| a prolonged antibiotic protocol to treat persistent chlamydophila pneumoniae infection improves the extracranial venous circulation in multiple sclerosis. | objective chronic cerebrospinal venous insufficiency (ccsvi) is a condition associated with multiple sclerosis (ms). one mechanism that has been proposed is that the venous obstructions found in ms are due to a chronic persistent venulitis caused by the intra-cellular bacterial parasite, chlamydophila pneumoniae (cpn). the objective of the current study is to determine the effect of a combined antibiotic protocol (cap) on the venous flow in ms patients as measured by a quantitative duplex ultras ... | 2017 | 28583026 |
| mucositis secondary to chlamydia pneumoniae infection: expanding the mycoplasma pneumoniae-induced rash and mucositis concept. | the term mycoplasma pneumoniae-induced rash and mucositis (mirm) was recently proposed to identify the mucocutaneous condition secondary to m. pneumoniae infection that had historically been regarded among the more confusing pathologies of erythema multiforme and stevens-johnson syndrome. based on a number of previous reports, these syndromes require differentiation since they have different prognoses and specific treatment requirements. we report a case of oral and genital erosions that strongl ... | 2017 | 28568680 |
| severe acute asthma caused by chlamydophila pneumoniae infection. | asthma exacerbation is associated with respiratory infections, including those by viruses and atypical bacteria. we herein report a case of severe acute asthma in an adult caused by chlamydophila pneumoniae (c. pneumoniae) infection. a 39-year-old woman without a history of asthma reported to the emergency department with progressive worsening of cough, shortness of breath, and wheezing with low oxygen saturation. a computed tomography (ct) scan revealed patchy ground-glass opacity and bronchial ... | 2017 | 28560041 |
| chlamydia pneumoniae induces interferon gamma responses in peripheral blood mononuclear cells in children with allergic asthma. | respiratory infections caused by chlamydia pneumoniae have been associated with exacerbations of asthma. cell-mediated immunity (cmi) is critical for maintaining immunity. we compared interferon (ifn)-γ responses in c. pneumoniae-infected peripheral blood mononuclear cells (pbmc) in paediatric patients ± asthma. presence of c. pneumoniae was tested from asthma patients (n = 17) and non-asthmatic controls (n = 16) (pcr). pbmc were infected for 1 h ± c. pneumoniae ar-39 (moi = 0.1) and cultured fo ... | 2017 | 28480606 |
| infectious agents is a risk factor for myxomatous mitral valve degeneration: a case control study. | the etiology of myxomatous mitral valve degeneration (mvd) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. the purpose of the study is to analyze the effect of mycoplasma pneumoniae (mp), chlamydophila pneumoniae (cp) and borrelia burgdorferi (bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve deg ... | 2017 | 28431520 |
| methods for real-time pcr-based diagnosis of chlamydia pneumoniae, chlamydia psittaci, and chlamydia abortus infections in an opened molecular diagnostic platform. | the advances in molecular biology of the last decades have dramatically improved the field of diagnostic bacteriology. in particular, pcr-based technologies have impacted the diagnosis of infections caused by obligate intracellular bacteria such as pathogens from the chlamydiacae family. here, we describe a real-time pcr-based method using the taqman technology for the diagnosis of chlamydia pneumoniae, chlamydia psittaci, and chlamydia abortus infection. the method presented here can be applied ... | 2017 | 28600769 |
| infection-mediated asthma: etiology, mechanisms and treatment options, with focus on chlamydia pneumoniae and macrolides. | asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. the worldwide incidence of asthma has increased dramatically in the last 40 years. according to world health organization (who) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. it is now well acce ... | 2017 | 28526018 |
| influence of antibiotics on the detection of bacteria by culture-based and culture-independent diagnostic tests in patients hospitalized with community-acquired pneumonia. | specimens collected after antibiotic exposure may reduce culture-based bacterial detections. the impact on culture-independent diagnostic tests is unclear. we assessed the effect of antibiotic exposure on both of these test results among patients hospitalized with community-acquired pneumonia (cap). | 2017 | 28480285 |
| in situ detection of chlamydia pneumoniae, c. trachomatis, and cytokines among cardiovascular diseased patients from the amazon region of brazil. | chronic coronary artery disease has been associated, as a consequence of the local inflammatory reaction with previous or persistent infection with chlamydia pneumoniae, which led to the investigation of the association of cardiovascular disease and previous infection with c. trachomatis and the role of cytokine profile (in situ) markers in the vascular system tissues. | 2017 | 28435302 |
| sphingolipids are dual specific drug targets for the management of pulmonary infections: perspective. | sphingolipids are the major constituent of the mucus secreted by the cells of epithelial linings of lungs where they maintain the barrier functions and prevent microbial invasion. sphingolipids are interconvertible, and their primary and secondary metabolites have both structural and functional roles. out of several sphingolipid metabolites, sphingosine-1 phosphate (s1p) and ceramide are central molecules and decisive for sphingolipid signaling. these are produced by enzymatic activity of sphing ... | 2017 | 28400772 |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| evolution of acute infection with atypical bacteria in a prospective cohort of children with community-acquired pneumonia receiving amoxicillin. | atypical bacteria are treatable causative agents of community-acquired pneumonia (cap). however, there is no conclusive evidence that a child with cap should receive empirical treatment against such agents. | 2017 | 28475737 |
| induction of vegf and mmp-9 expression by toll-like receptor 2/4 in human endothelial cells infected with chlamydia pneumoniae. | matrix metalloproteinases (mmp) are a family of host-derived enzymes involved in the turnover of extracellular matrix (ecm) molecules, and, in particular, it is demonstrated that the 92 kda gelatinase mmp-9 is often expressed in atherosclerotic plaques by macrophages and smooth muscle cells. recent evidence supports a role of toll-like receptor (tlr) signaling in the development of atherosclerosis lesions. in this study, we analyzed the tlr2/tlr4 expression in huvec infected with c. pneumoniae a ... | 2017 | 22697069 |
| hyperbolic relation between beta-cell function and insulin sensitivity for type 2 diabetes mellitus, malaria, influenza, helicobacter pylori, chlamydia pneumoniae, and hepatitis c virus infection-induced inflammation/oxidative stress and temporary insulin resistance in central africans | background/aim: we calculated the homeostatic model assessment (homa) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, hiv, helicobacter pylori, chlamydia pneumoniae, and hepatitis c virus), type 2 diabetic black patients, and healthy controls from kinshasa, dr congo. materials and methods: a case-control study was carried out between 2006 and 2007 for black central african participants managed for homa.results: in tot ... | 2017 | 29306246 |
| development of a multiplex taqman real-time pcr assay for the detection of chlamydia psittaci and chlamydia pneumoniae in human clinical specimens. | diagnosis of chlamydia psittaci and chlamydia pneumoniae infections has traditionally relied on serological assays. we developed a multiplex real-time pcr assay for detection of c. psittaci, c. pneumoniae and an internal control. results of this assay demonstrated 100% concordance compared to results of previously tested human clinical specimens. | 2017 | 29291900 |
| [large vessel vasculitis : pathogenesis, diagnostic and medical management]. | large vessels vasculitis includes two diseases : 1) giant cell arteritis, formerly known as horton's arteritis and 2) takayasu arteritis. in this article, we will describe and compare the epidemiology, pathogenesis, diagnostic criteria and medical management of both vasculitis. t helper (th) 1 and th17 responses, genetic links and the role of viral (varicella zoster) and bacterial infection (mycoplasma pneumoniae or chlamydia pneumoniae) will be discussed. classification criteria, inflammation b ... | 2017 | 28722366 |
| hypothetical protein cpn0423 triggers nod2 activation and contributes to chlamydia pneumoniae-mediated inflammation. | chlamydia pneumoniae (c. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. however, the molecular signals linking c. pneumoniae components to inflammation remain elusive. this study was to investigate the effect of chlamydia-specific cpn0423 of c. pneumoniae on c. pneumoniae-mediated inflammation. | 2017 | 28693414 |
| iron homeostasis in tissues is affected during persistent chlamydia pneumoniae infection in mice. | chlamydia pneumoniae (c. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. for its growth c. pneumoniae depends on iron (fe), but how fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. c. pneumoniae-infected c57bl/6j mice were sacrificed on days 4, 8, 20, and 40. mice had bacteria in the lungs and liver on all days. inflammatory markers, chemokine cxcl2 and interferon-gamma, were not affected in the liver on day 40. the c ... | 2017 | 28691023 |
| robust immunoreactivity of teenager sera against peptide 19 from porphyromonas gingivalis hsp60. | epitope spreading is a phenomenon in which distinct subdominant epitopes become major targets of the immune response. heat shock protein (hsp) 60 from porphyromonas gingivalis (pghsp60) and peptide 19 from pghsp60 (pep19) are immunodominant epitopes in autoimmune disease patients, including those with periodontitis. it remains unclear whether pep19 is a dominant epitope in subjects without periodontitis or autoimmune disease. the purpose of this study was to determine the epitope spreading patte ... | 2017 | 28680713 |
| lack of association of chlamydia pneumoniae with cardiovascular diseases in virologically suppressed hiv patients. | cardiovascular disease (cvd) is a major public health problem in developed countries with over 17 million deaths per year. in the last decade, several infectious agents rather than any single pathogen, including chlamydia pneumoniae and human immunodeficiency virus (hiv), have been shown to contribute to the development of atherosclerosis and subsequent cardiovascular events by inducing systemic inflammation and/or acting directly on the vascular wall. for the first time, we evaluated c. pneumon ... | 2017 | 27819396 |
| progress and future opportunities in the development of vaccines against atherosclerosis. | atherosclerosis represents a serious global health problem that demands new therapeutic and prophylactic interventions. considering that atherosclerosis has autoimmune and inflammatory components, immunotherapy is a possible focus to treat this disease. areas covered: based on the analysis of the current biomedical literature, this review describes the status on the development of vaccines against atherosclerosis. several targets have been identified including sequences of apolipoprotein b100 (a ... | 2017 | 27817213 |
| classification and functional analyses of putative conserved proteins from chlamydophila pneumoniae cwl029. | chlamydophila pneumoniae, a gram-negative bacterium belongs to the family chlamydiaceae, is known to cause community-acquired pneumonia and bronchitis. there is a need for genomic analyses of c. pneumoniae as its chronic infections result in reactive airway disease, lung cancer and asthma. recent advancement in the sequencing techniques led to the generation of large genomic data. in order to utilize these data, sequence-based function predictions were used for annotating the uncharacterized gen ... | 2017 | 26649559 |
| molecular characterization of chlamydia pneumoniae associated to atherosclerosis. | chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. the main objective of our study was to evaluate the association between chlamydia pneumoniae and atherosclerosis in moroccan patients through a case/control approach and detected strain genotyping. a total of 137 cases and 124 controls were enrolled, nes ... | 2017 | 28387800 |
| chlamydia pneumoniae infection promotes vascular endothelial cell angiogenesis through an iqgap1-related signaling pathway. | chlamydia pneumoniae (c. pneumoniae) infection plays a potential role in angiogenesis. however, it is still an enigma how c. pneumoniae is involved in this process. therefore, we investigated the effect of c. pneumoniae infection on angiogenesis, and then explored the roles of iqgap1-related signaling in c. pneumoniae infection-induced angiogenesis. c. pneumoniae infection significantly enhanced angiogenesis as assessed by the tube formation assay possibly by inducing vascular endothelial cell ( ... | 2017 | 28377051 |
| the relationship of chlamydophila pneumoniae with schizophrenia: the role of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in this relationship. | several pathogens have been suspected of playing a role in the pathogenesis of schizophrenia. chronic inflammation has been proposed to occur as a result of persistent infection caused by chlamydophila pneumoniae cells that reside in brain endothelial cells for many years. it was recently hypothesized that brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) may play prominent roles in the development of schizophrenia. nt-3 and bdnf levels have been suggested to change in response ... | 2017 | 28256360 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| contribution of common infections to cardiovascular risk in hiv positive individuals. | hiv-positive individuals are at increased risk for cardiovascular disease due to complex interactions between the increased incidence of traditional cardiovascular risk factors and hiv and antiretroviral-associated inflammation and dyslipidemia. increasing evidence suggests that a number of important co-pathogens, including cytomegalovirus, hepatitis c virus, and periodontal disease, are likely to also be contributing. mechanisms such as molecular mimicry and modification of lipids play a role; ... | 2017 | 28182619 |
| insights into structure and function of 30s ribosomal protein s2 (30s2) in chlamydophila pneumoniae: a potent target of pneumonia. | the gene 30s ribosomal protein s2 (30s2) is identified as a potential drug and vaccine target for pneumonia. its structural characterization is an important to understand the mechanism of action for identifying its receptor and/or other binding partners. the comparative genomics and proteomics studies are useful for structural characterization of 30s2 in c. pneumoniae using different bioinformatics tools and web servers. in this study, the protein 30s2 structure was modelled and validated by ram ... | 2017 | 27866051 |
| lower-leg cellulitis-like manifestations of erythema nodosum induced by chlamydophila pneumoniae infection. | 2017 | 27057055 | |
| is there a relationship between parkinson's disease and chlamydia pneumoniae? | the aim was to investigate a possible relationship between chlamydia pneumoniae and parkinson's disease (pd). | 2017 | 26096238 |
| role of pathogens in multiple sclerosis. | multiple sclerosis (ms) is an inflammatory demyelinating autoimmune disease of the central nervous system (cns). although the etiology of ms is unknown, genetic and environmental factors play a role. infectious pathogens are the likely environmental factors involved in the development of ms. pathogens associated with the development or exacerbation of ms include bacteria, such as mycoplasma pneumoniae and chlamydia pneumoniae, the staphylococcus aureus-produced enterotoxins that function as supe ... | 2017 | 24266364 |
| application of serology and nested polymerase chain reaction for identifying chlamydophila pneumoniae in community-acquired lower respiratory tract infections in children. | chlamydophila pneumoniae is a common cause of community-acquired respiratory infections, including pneumonia, bronchitis, and upper respiratory tract infections. since it is difficult to detect c. pneumoniae in clinical practice, specific etiological diagnosis is established only in a minority of cases. | 2017 | 27721281 |
| peptide 19 of porphyromonas gingivalis heat shock protein is a potent inducer of low-density lipoprotein oxidation. | although periodontal pathogens show a strong association with development of atherosclerosis, little is known about how a microorganism contributes to disease onset and progression. oxidation of low-density lipoprotein (ldl) is a major risk factor of atherogenesis. the principal objective of this study is to evaluate the ability of peptide 19 (pep19) of porphyromonas gingivalis (pg) heat shock protein (hsp) as a potent inducer of ldl oxidation, and a secondary objective is to compare this abilit ... | 2017 | 27712463 |
| recent advances and future directions in understanding and treating chlamydia-induced reactive arthritis. | reactive arthritis (rea) is an inflammatory disease that can follow gastrointestinal or genitourinary infections. the primary etiologic agent for post-venereal rea is the bacterium chlamydia trachomatis; its relative, c pneumoniae, has also been implicated in disease induction although to a lesser degree. studies have indicated that the arthritis is elicited by chlamydiae infecting synovial tissue in an unusual biologic state designated persistence. we review clinical aspects, host-pathogen inte ... | 2017 | 27627462 |
| neonatal apnea with chlamydia pneumoniae infection. | 2017 | 28102626 | |
| prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae igm and igg antibodies in tunisian patients presenting with exacerbation of chronic obstructive pulmonary disease. | we aimed to assess the prevalence of chlamydophila pneumoniae and mycoplasma pneumoniae acute infections, using serological testing, in patients admitted to the emergency department for acute exacerbations of chronic obstructive pulmonary disease (copd). | 2017 | 28062246 |
| infectious burden and semen parameters. | to investigate the relationship between chronic infections detected in serum and semen quality. the pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. previous observations that helicobacter pylori infection may reduce the semen quality prompted us to perform the present study. | 2017 | 27793655 |
| simkania negevensis, an insight into the biology and clinical importance of a novel member of the chlamydiales order. | simkania negevensis is a chlamydia-related bacterium discovered in 1993 and represents the founding member of the simkaniaceae family within the chlamydiales order. as other chlamydiales, it is an obligate intracellular bacterium characterized by a biphasic developmental cycle. its similarities with the pathogenic chlamydia trachomatis and chlamydia pneumoniae make it an interesting bacterium. so far, little is known about its biology, but s. negevensis harbors various microbiological characteri ... | 2017 | 27786615 |
| chlamydial antibiotic resistance and treatment failure in veterinary and human medicine. | the chlamydiaceae are widespread pathogens of both humans and animals. chlamydia trachomatis infection causes blinding trachoma and reproductive complications in humans. chlamydia pneumoniae causes human respiratory tract infections and atypical pneumonia. chlamydia suis infection is associated with conjunctivitis, diarrhea, and failure to gain weight in domestic swine. chlamydial infections in humans and domesticated animals are generally controlled by antibiotic treatment-particularly macrolid ... | 2017 | 27218014 |
| infectious agents and neurodegenerative diseases: exploring the links. | recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as amyotrophic lateral sclerosis (als), multiple sclerosis (ms), alzheimer's disease (ad), and lyme disease (ld). however, it is still controversial how the infections play a role in neurological diseases progression. infections in central nervous system may lead multiple damages in infected and neighboring cells. the infection leads to the activation of inflammatory process ... | 2017 | 28049398 |
| cholesterol uptake in the mouse aorta increases during chlamydia pneumoniae infection. | 2017 | 28158541 | |
| the role of nod-like receptors in pulmonary infection. | pneumonia is caused by both viral and bacterial pathogens and is responsible for a significant health burden in the unites states. the innate immune system is the human body's first line of defense against these pathogens. the recognition of invading pathogens via pattern recognition receptors (prrs) leads to proinflammatory cytokine and chemokine production followed by recruitment and activation of effector immune cells. the nonspecific inflammatory nature of the innate immune response can resu ... | 2017 | 28157451 |
| high prevalence of mycoplasma pneumoniae and chlamydia pneumoniae in children with acute respiratory infections from lima, peru. | mycoplasma pneumoniae and chlamydia pneumoniae are atypical pathogens responsible for pneumonia and a leading cause of morbidity and mortality in low income countries. the study objective is to determine the prevalence of this pathogens in peruvian children with acute respiratory infections. | 2017 | 28129377 |
| prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with hiv. | the study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. the objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with hiv. patients were submitted to an extended microbiological investigation that included molecular methods. the microbiological findings were eva ... | 2017 | 28121925 |
| risk factors for acute myocardial infarction in central india: a case-control study. | atherosclerosis is a multi-factorial disease involving the interplay of genetic and environmental factors. studies highlighting the public health importance of risk factors like chronic infections causing acute myocardial infarction (ami) in the indian context are scarce. this study was undertaken to study the association of socio-demographic and life-style factors with acute myocardial infarction in central india. | 2017 | 25657508 |
| evidence for horizontal gene transfer between chlamydophila pneumoniae and chlamydia phage. | chlamydia-infecting bacteriophages, members of the microviridae family, specifically the gokushovirinae subfamily, are small (4.5-5 kb) single-stranded circles with 8-10 open-reading frames similar to e. coli phage ϕx174. using sequence information found in genbank, we examined related genes in chlamydophila pneumoniae and chlamydia-infecting bacteriophages. the 5 completely sequenced c. pneumoniae strains contain a gene orthologous to a phage gene annotated as the putative replication initiatio ... | 2017 | 26713222 |
| impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (chlamydia trachomatis and chlamydia pneumoniae) in immortal human epithelial hela cells. | chlamydia trachomatis is the leading cause of sexually transmitted infections worldwide. capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor trpv1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via pparγ (peroxisome proliferator-activated receptor-γ) and lxrα (liver x receptor α), is a potential candidate to control chlamydial growth in host cells. we examined whether capsaicin could inhibit c. trachomatis growth in immort ... | 2018 | 29132924 |
| chlamydia pneumoniae exploits adipocyte lipid chaperone fabp4 to facilitate fat mobilization and intracellular growth in murine adipocytes. | fatty acid-binding protein 4 (fabp4), a cytosolic lipid chaperone predominantly expressed in adipocytes and macrophages, modulates lipid fluxes, trafficking, signaling, and metabolism. recent studies have demonstrated that fabp4 regulates metabolic and inflammatory pathways, and in mouse models its inhibition can improve type 2 diabetes mellitus and atherosclerosis. however, the role of fabp4 in bacterial infection, metabolic crosstalk between host and pathogen, and bacterial pathogenesis have n ... | 2018 | 29108997 |