Publications

bacteriology and cefuroxime-resistance in endophthalmitis following cataract surgery before and after the introduction of prophylactic intracameral cefuroxime: a retrospective single-centre study.	intracameral cefuroxime as prophylaxis against postoperative endophthalmitis (poe) following cataract surgery was introduced in 1996 at st erik eye hospital. soon after the introduction of intracameral cefuroxime the rate of poe fell dramatically and a shift in the aetiology was noticed.	2018	29432821
propionibacterium acnes abundance correlates inversely with staphylococcus aureus: data from atopic dermatitis skin microbiome.	the microbiome may influence disease severity in atopic dermatitis. the skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. optical density measurements were used to investigate bacterial growth under defined conditions in vitro. lesional skin from patients with atopic dermatitis had a higher abundance of s. aureus and reduced quantities of propionibacterium acnes and lawsonella c ...	2018	29379979
propionibacterium acnes strains differentially regulate the fate of th17 responses in the skin.	agak et al. demonstrate that different strains of propionibacterium acnes, a bacterium colonizing pilosebaceous units in healthy skin and acne, have the ability to induce t helper type 17 cells secreting either ifn-γ or il-10 and exhibiting either pathogenic or protective properties, respectively. this work contributes to growing evidence indicating that the phenotype of t helper type 17 cells is largely dependent on their microbiological environment.	2018	29389326
epidermal growth factor attenuated the expression of inflammatory cytokines in human epidermal keratinocyte exposed topropionibacterium acnes.	while the beneficial effects of topical epidermal growth factor (egf) on wound healing have been repeatedly reported, there are few reports about the effects of egf on inflammatory skin diseases including acne.	2018	29386833
platelet activation and aggregation by the opportunistic pathogen cutibacterium (propionibacterium) acnes.	cutibacterium (propionibacterium) acnes, considered a part of the skin microbiota, is one of the most commonly isolated anaerobic bacteria from medical implants in contact with plasma. however, the precise interaction of c. acnes with blood cells and plasma proteins has not been fully elucidated. herein, we have investigated the molecular interaction of c. acnes with platelets and plasma proteins. we report that the ability of c. acnes to aggregate platelets is dependent on phylotype, with a sig ...	2018	29385206
on revealing the gene targets of ebola virus micrornas involved in the human skin microbiome.	ebola virus, a negative-sense single-stranded rna virus, causes severe viral hemorrhagic fever and has a high mortality rate. histopathological and immunopathological analyses of ebola virus have revealed that histopathological changes in skin tissue are associated with various degrees of endothelial cell swelling and necrosis. the interactions of microbes within or on a host are a crucial for the skin immune shield. the discovery of micrornas (mirnas) in ebola virus implies that immune escape, ...	2018	29312814
the antimicrobial effect of cen1hc-br against propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris.	propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. an antimicrobial peptide named cen1hc-br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against p. acnes. to examine the potency of cen1hc-br in acne treatment, we conducted experiments to analyze the antibacterial and anti- ...	2018	29108811
contamination occurs during acl graft harvesting and manipulation, but it can be easily eradicated.	why anterior cruciate ligament (acl) autograft soaking in a 5 mg/ml vancomycin solution decreases the rate of infection has not been well-explained. one hypothesis is that grafts can be contaminated during harvesting and vancomycin eradicates the bacteria. the purpose of the present study is to assess how the vancomycin solution acts against acl graft contamination during graft harvesting and preparation.	2018	28988312
decrease in diversity of propionibacterium acnes phylotypes in patients with severe acne on the back.	propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: ia1, ia2, ib, ic, ii and iii. this study investigated p. acnes subgroups on the face and back in patients with severe acne and in healthy controls. in 71.4% of patients with severe acne, p. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. the healthy group carried phylotypes ia1 (39.1%) and ii (43.4%), whereas the acne group carried ...	2018	29136261
perioperative antibiotic prophylaxis has no effect on time to positivity and proportion of positive samples: a cohort study of 64 cutibacterium acnes bone and joint infections.	if a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. this practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. we aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion ...	2018	29167293
topical delivery of erythromycin through cubosomes for acne.	topical delivery is an attractive route for local and systemic treatment. novel topical application has many advantages like avoids the gi-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug over the conventional dosage forms. the aim of present work was to prepared and characterized erythromycin encapsulated cubosomes using different concentration of glyceryl monooleate and poloxamer 407 by emulsification method. the prepared dispersion of cuboso ...	2018	29424323
detection of bacteria colonizing titanium spinal implants in children.	bacterial colonization of spinal implants may cause severe complications in patients with early-onset scoliosis. correct diagnosis and detection of microbiologic formation is crucial to prevent delayed infections caused by bacterial colonization. the purposes of this study were to estimate the rate and risk factors of colonization of vertical expandable prosthetic titanium rib (veptr) implants in children and to compare the different methods for detecting microbiologic formation on the spinal im ...	2018	29190173
the human skin microbiome.	functioning as the exterior interface of the human body with the environment, skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. the harsh physical landscape of skin, particularly the desiccated, nutrient-poor, acidic environment, also contributes to the adversity that pathogens face when colonizing human skin. despite this, the skin is colonized by a diverse microbiota. in this review, we describe amplicon and shotgun ...	2018	29332945
shunt nephritis: an increasingly unfamiliar diagnosis.	shunt nephritis is a rare, reversible immune-complex mediated complication of csf shunt infection that can progress to end-stage renal disease and even death if diagnosis is delayed.	2018	29325951
propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the tlr2/jnk/mitochondrial-mediated pathway.	evidence suggests that intervertebral disc degeneration (ivdd) can be induced by propionibacterium acnes (p. acnes), although the underlying mechanisms are unclear. in this study, we analyzed the pathological changes in degenerated human intervertebral discs (ivds) infected with p. acnes. compared with p. acnes-negative samples, p. acnes-positive ivds showed increased apoptosis of nucleus pulposus cells (npcs) concomitant with severe ivdd. then, a p. acnes-inoculated ivd animal model was establi ...	2018	29323102
acne in late adolescence and risk of prostate cancer.	accumulating evidence suggest that propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. the aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. we identified a large cohort of young men born in sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the ag ...	2018	29205339
[pseudarthrosis and construct failure after lumbar pedicle subtraction osteotomy : influence of biomechanics, surgical technique, biology and avoidance strategies].	there are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (pso) in the lumbar spine. frequently, several factors are of relevance in these problematic cases. this article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. it addresses technical varieties of the pso procedure as well as the surgical technique, th ...	2018	29411050
a rationally designed multi-functional antibiotic for the treatment of drug-resistant acne.	acne is a multifactorial skin disease, underpinned by colonization of propionibacterium acnes and inflammation. the emergence of resistant propionibacterium acnes strains has affected the current acne treatment algorithm. this setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant propionibacterium acnes as well as exert an immunomodulatory function to reduce inflammation. in silico screening revealed that on ...	2018	29409921
propionibacterium acnes suture contamination in arthroscopic rotator cuff repair: a prospective randomized study.	to examine the contamination rate of the anchor-suture and to determine the efficacy of 2 different surgical skin preparation solutions with or without a plastic adhesive drape from suture contamination in arthroscopic rotator cuff repair.	2018	29373294
a profile of propionibacterium acnes resistance and sensitivity at a tertiary dermatological centre in singapore.	propionibacterium acnes (p. acnes) is a key component in the pathogenesis of acne. both topical and oral antibiotics are key therapeutic options. unfortunately, antibiotic resistance is rapidly increasing globally. many countries have reported greater than 50% of p.acnes strains acquiring resistance to topical macrolides1-3. in singapore, antibiotic resistance rates of 8% in 19994rising to 14.9%5in 2007 were reported. we aimed to update the local prevalence of antibiotic resistance and identify ...	2018	29368337
prevalence of propionibacterium acnes in the glenohumeral compared with the subacromial space in primary shoulder arthroscopies.	we hypothesized that the prevalence of propionibacterium acnes in patients undergoing primary shoulder arthroscopy is equal in the glenohumeral space compared with the subacromial space.	2018	29361412
bacterial colonisation of suture material after routine neurosurgical procedures: relevance for wound infection.	wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity, increased cost and patient discomfort. here we aimed to investigate the relevance of bacterial colonisation on suture material using polymerase chain reaction (pcr) to detect and taxonomically classify bacterial dna in patients with and without wound healing problems after routine neurosurgical procedures.	2018	29189910
microbiology alloplastic total joint infections: a 20-year retrospective study.	prosthetic joint infection (pji) is a rare complication of temporomandibular joint replacement (tjr). this study evaluated tjr pjis at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of tjr.	2018	29178982
susceptibility of enterococcus faecalis and propionibacterium acnes to antimicrobial photodynamic therapy.	bacterial resistance to available antibiotics nowadays is a global threat leading researchers around the world to study new treatment modalities for infections. antimicrobial photodynamic therapy (apdt) has been considered an effective and promising therapeutic alternative in this scenario. briefly, this therapy is based on the activation of a non-toxic photosensitizing agent, known as photosensitizer (ps), by light at a specific wavelength generating cytotoxic singlet oxygen and free radicals. ...	2018	29253813