Publications

brefeldin a-induced increase of sphingomyelin synthesis. assay for the action of the antibiotic in mammalian cells.	brefeldin a leads to an increase of sphingomyelin in chinese hamster ovary cells. the antibiotic is known to cause a dramatic morphological change of the endomembrane system in various mammalian cells resulting in a redistribution of golgi resident proteins to the endoplasmic reticulum (lippincott-schwartz, j., donaldson, j. g., schweizer, a., berger, e. g., hauri, h. p., yuan, l. c., and klausner, r. d. (1990) cell 60, 821-836). a strict correlation was found between the brefeldin a-induced inc ...	1978	1544889
[clinical symptomatology and systematization of esophagospasm].		1978	1145278
virus envelopes and plasma membranes.	in this review i have tried to describe the progress that has been made in studies of viral envelopes in the last few years. in every particular of structure, biogenesis, and assembly, increased knowledge has increased the apparent similarity between viral envelopes and plasma membranes. thus, the viral envelopes provide unique experimental opportunities for investigating membranes. we can expect that progress in our understanding of membrane structure will continue through the study of viral en ...	1978	352238
phase ii trial of pyrazofurin in patients with multiple myeloma refractory to standard cytotoxic therapy.		1978	476714
[results of antiestrogen therapy in metastasizing breast cancer].		1978	414048
relative activity of atenolol and metoprolol.		1978	352474
[nikolai grigor'evich kolosov (on his 80th birthday)].		1978	352306
otitis media in children: a prospective study of aerobic and anaerobic bacteriology.	tympanocentesis with aerobic and anaerobic cultivation of middle ear fluid was performed through one or both tympanic membranes of 186 children with acute otitis media. aerobic bacteria alone, predominantly pneumococcus and hemophilus influenzae, were isolated from 118 (63.4%) patients: and anaerobic organisms alone, most commonly peptococcus, from 24 (12.9%). twenty-six (14%) yielded mixtures of aerobes and anaerobes, and several had multiple aerobic agents. no bacterial growth was noted in 18 ...	1979	36523
the microbiology of serous and mucoid otitis media.	one hundred forty-four serous and mucoid effusions were cultured for aerobic bacteria, mycoplasma pneumoniae, and virus. thirty percent of all effusions yielded an unequivocally positive culture for aerobic bacteria. although serous effusions were culture positive as often as mucoid effusions, haemophilus influenzae was isolated predominantly from serous effusions and staphylococcus epidermidis predominantly from mucoid samples. only one of 73 effusions yielded a viral isolate (herpesvirus homin ...	1979	36591
otitis media with effusion. cytological and microbiological correlates.	a quantitative cytologic study of 83 middle ear effusions from children with otitis media with effusion (ome) was made with the use of cytocentrifuge-prepared smears and was correlated with bacteriological findings. the identification of the types of cell present in an effusion was confirmed by electron microscopic findings. the most common cell types were neutrophilic leukocytes, lymphocytes, and macrophages, but a few eosinophils were found in only one case. the cytologic profile of an effusio ...	1979	36875
cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use.	cefuroxime is a new semisynthetic cephalosporin for parenteral administration. it is resistant to destruction by beta-lactamases produced by staphylococci and most gram-negative aerobic bacteria and is active against many bacteria resistant to cephalothin. cefuroxime is the most active of the cephalosporins against gonococci and haemophilus influenzae particularly against beta-lactamase producing strains. given by intramuscular or intravenous injection cefuroxime is effective against a wide vari ...	1979	37064
cellulitis of the face caused by hemophilus influenzae during childhood.		1979	37202
upper respiratory tract spread of group b streptococci type i b in a kindergarten.	in a kindergarten with 42 children and 17 female staff members, an epidemic of group b streptococcal carriage in the upper respiratory tract occurred. in the middle of february 1978, 6 children and 5 adults carried type i b streptococci in the throat while only 2 of these 11 were carriers 2 weeks later. only one other streptococcus, belonging to type ii, was found in the throat specimens. five strains other than type i b were found in the urogenital tract of the staff. three type i b throat carr ...	1979	37592
bactericidal action of an average dose of erythromycin in the bronchi.	a study was carried out to establish whether erythromycin stearate was bacteriostatic or bactericidal at the concentrations reached in the bronchial secretion. twenty-two patients suffering from an acute attack of chronic bronchitis, sustained by streptococci, diplococci, staphylococci or h. influenzae sensitive to erythromycin, were treated with 1500 mg erythromycin per day until symptoms regressed, usually within 3 to 5 days. the results showed that after treatment there was a dramatic reducti ...	1979	38063
[comparative sensitivities of six different species of mosquitoes to bacillus thuringiensis var. israelensis].		1979	34488
comparison of staphylococcal coagglutination, latex agglutination, and counterimmunoelectrophoresis for bacterial antigen detection.	soluble antigens of haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus were looked for in cerebrospinal fluid, serum, and urine by using the staphylococcal coagglutination test, latex agglutination test, and counterimmunoelectrophoresis. the staphylococcal coaggultination and latex agglutination tests were more sensitive than counterimmunoelectrophoresis in identifying antigens of h. influenzae type b, s. pneumoniae, and n. meningitidis. no ...	1979	34622
evaluation of blood culture procedures in a pediatric hospital.	to determine optimal clinical laboratory techniques for detecting pediatric bacteremia, we studied 7,768 consecutive blood cultures in a 1-year period. blood was inoculated into one vented 50-ml bottle of brucella broth with 0.05% sodium polyanetholsulfonate and one unvented 50-ml bottle of columbia broth with 0.05% sodium polyanetholsulfonate and 0.05% cysteine. bottles were visually examined for growth on days 1 through 7 and blindly subcultured aerobically and anaerobically on days 1, 2, and ...	1979	34623
chromogenic cephalosporin spot test to detect beta-lactamase in clinically significant bacteria.	lactamase production. reacteroides melaniongenicus, 14	1979	34624
the nasopharyngeal culture in acute otitis media. a reappraisal of its usefulness.	simultaneous cultures of the nasopharynx and middle ear exudate (obtained by tympanocentesis) were obtained from 225 children (mean age, 34 months; median age, 41 months) with suppurative otitis media. a 72% prediction rate for middle ear pathogens was obtained by examining the nasopharyngeal cultures after the strict observance of two essential prerequisites: (1) the nasopharyngeal culture was immediately plated on appropriate solid agar and (2) a semiquantitative method for bacterial enumerati ...	1979	34739
[rolitetracycline in lung and biliary tract infections].		1979	34790
[modern data on the antibiotic sensitivity of the microflora that is an etiological factor in ent diseases. ii. the antibiotic sensitivity of pneumococci, meningococci, influenza bacilli, klebsiella, enterobacteria, pseudomonas aeruginosa and proteus].		1979	34945
k+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: obliteration by amiloride.		1979	35009
etiology and antimicrobial therapy of acute maxillary sinusitis.	eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). fifty-nine bacterial strains were isolated in titers of greater than or equal to 10(4) colony-forming units/ml; streptococcus pneumoniae and haemophilus influenzae accounted for 64% of the isolates. other bacteria recovered included anaerobes (12%), neisseria species (8.5%). streptococcus pyogenes (3%), alpha-hemolytic streptococcus (3%), non-group a beta ...	1979	35571
opportunist lung infections.		1979	33268
[bacterial polysaccharides--a new generation of vaccines].		1979	33301
kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects.	the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ...	1979	33396
counterimmunoelectrophoresis of sputum and blood for the diagnosis of chest infections caused by pneumococci or haemophilus influenzae.	in 107 patients with lower respiratory tract infections, counterimmunoelectrophoresis (cie) of blood and sputum, bacterial cultures of blood, sputum and nasopharyngeal secretion, and enzyme-linked immunosorbent assay (elisa) for antibody determination were performed, with special reference to pneumococci and haemophilus influenzae. for pneumococci cie of sputum was superior to culture especially in antibiotic-treated patients. the clinical significance of a positive cie of sputum was supported b ...	1979	33446
metabolic activation of 2,4-diaminoanisole, a hair-dye component--ii. role of cytochrome p-450 metabolism in irreversible binding in vitro.		1979	31890
cellular cooperation in lymphocyte activation. ii. cooperative response of human peripheral t and b lymphocytes to rabbit anti-human beta 2-microglobulin.	in the present study we attempted to clarify the effects of anti-beta 2-microglobulin (a-beta 2m) on lymphocyte activation. neither a-beta 2m igg fraction nor f(ab')2 had a mitogenic effect on either highly purified t or b lymphocytes alone, while their mitogenic effect was observed when t and b lymphocytes were appropriately reconstituted. when t lymphocytes were reconstituted with mitomycin c (mmc) treated b lymphocytes, a negligible decrease in the response to a-beta 2m was observed compared ...	1979	89920
a functional measure of brain activity: brain stem transmission time.	surface-recorded auditory nerve and brain stem responses are being used routinely for diagnostic purposes in man. when interest is in auditory diagnosis, the electric response threshold is of primary importance. however, when used in neurological diagnosis, the wave form of the response is important. as a measure of one aspect of response wave form, this paper suggests the use of brain stem transmission time (btt), defined as the time interval between the first earlobe-negative wave (response of ...	1979	89952
retrograde axonal transport of horseradish peroxidase in regenerating sciatic nerve of the rat.		1979	89965
ribosomal ambiguity (ram) mutations facilitate diyhydrostreptomycin binding to ribosomes.		1979	89972
[phospholipids and blood coagulation].	after a simplified survey of the chemistry of phospholipids (pl) their presence in the lipid part of thromboplastin is dealt with, the significance of this structure being stressed. in addition, the condition, mode of action and synthesis of pl in blood platelets are extensively discussed and the impact of the composition of thrombocytic pl in the membrane and granular fraction by plasma lipid substances is referred to. the relations between single forms of pl and those proteins activating coagu ...	1979	89981
human blood t lymphocytes that suppress the mixed leukocyte culture reactivity of lymphocytes from hla-b14 bearing individuals.	a nontransfused male patient with recurrent bladder carcinomata has been demonstrated to have blood t lymphocytes that suppress the mlc responsiveness of lymphocytes only from normal individuals positive for hla-b14. unexpectedly, this t-suppressor cell differs from three other reported blood t-suppressor cells arising in man in that it apparently does not require hla-d locus compatibility between the suppressor cell and the lymphocyte being suppressed.	1979	90092
effects of indomethacin on cyclic nucleotide levels and histamine release from rat serosal mast cells.		1979	90096
effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro.		1979	90097
purification of measles virus with preservation of infectivity and antigenicity.	measles virus edmonston strain was purified by ultrafiltration followed by two successive sedimentations through sucrose. purified virus retained infectivity and, when used as an immunogen, elicited high titred antibody to measles antigens by conventional serology. the measles preparations were examined by sds-page followed by staining. in addition, following page, the purity of these preparations was assessed immunochemically using antisera directed to measles and host cell antigens. the result ...	1979	90118
the effect of cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs.	cop 1, a synthetic polypeptide, was evaluated for its effect on a chronic relapsing form of experimental allergic encephalomyelitis (eae). pretreatment of juvenile strain 13 guinea pigs with cop 1 in incomplete freund's adjuvant (ifa) which were subsequently challenged with guinea pig spinal cord in complete freund's adjuvant (cfa) had a marked effect in delaying or preventing the appearance of clinical signs of eae. administration of cop 1 on appearance of clinical signs of eae prevented progre ...	1979	90129
a reliable golgi-kopsch modification.	a reliable golgi-kopsch variant is described. tissue is fixed with 1% paraformaldehyde, 1% glutaraldehyde in 0.1 m phosphate buffer, ph 7.2. tissue slabs (2.5--4 thick) are immersed for 5--7 days in a solution containing 3.5 g potassium dichromate, 15 g sucrose, 1.65 ml formaldehyde in 100 ml distilled water, washed briefly in 0.75% silver nitrate, and immersed in 0.75% silver nitrate for 2--3 days. procedures for cutting, counterstaining, and handling sections are described.	1979	89002
the pathophysiology of asthma.	because postmortem studies of humans provide little information on the initial pathophysiologic events in asthma, animal models have been developed. recently the ascaris-allergic rhesus monkey has provided an opportunity to examine the onset of pathophysiologic changes following challenge and to correlate them with airway structure. these studies have suggested that the initial interaction between antigen and mast cells may occur in the bronchial lumen or in the epithelium superficial to the tig ...	1979	89006
reaction of cells from early chick embryos with antiserum against mouse sperm cells.		1979	89009
mac-1: a macrophage differentiation antigen identified by monoclonal antibody.		1979	89034
the central cervical nucleus in the cat. ii. the cerebellar connections studied with retrograde transport of horseradish peroxidase.	after hrp injections in kittens and adult cats into parts of the cerebellum known to receive spinal afferents, retrogradely labelled neurones were found in the c1--c4 segments of the spinal cord, primarily in the central cervical nucleus (ccn). a few labelled neurones were also found in laminae iv and vi--ix of rexed. the results obtained in kittens and adult cats were similar. control hrp injections were made into the vestibular nuclei and the inferior colliculus. after injections mainly involv ...	1979	89038
cyclic amp and lipogenesis in fat cells from thyroidectomized rats.	thyroid hormones regulate lipid metabolism by affecting lipogenesis as well as lipolysis. the present paper discusses the way thyroidectomy induced an enhancement in lipogenesis in rat fat cells. the doubling in the conversion of glucose to co2 and fatty acids seen after thyroidectomy was found to be due to a modification in the actual pathway of glucose metabolism: there was a preferential stimulation of the conversion of glucose to co2 by the pentose cycle (utilisation of [1-14c]glucose) while ...	1979	89052
immunofluorescent staining of platelet suspensions and detection of antiplatelet antibody in patients with idiopathic thrombocytopenic purpura.	direct immunofluorescent staining of 31 specimens of platelets obtained from 13 cases of idiopathic thrombocytopenic purpura (itp) revealed positive staining on the surface of platelets for both immunoglobulins (igs) and human b1c globulin in 9 specimens, for only igs in 1 specimen and for human b1c alone in 5 specimens. the pattern of the positive immunofluorescent staining was granular. indirect immunofluorescent staining of normal platelets in serum obtained from patients with itp was positiv ...	1979	88810
differentiation between cyclic amp level and allergic histamine release in mast cells [proceedings].		1979	88891
the influence of cyclic nucleotides on histamine release from rat peritoneal mast cells [proceedings].		1979	88893
climate and the evolution of skull metrics in man.	two types of data, anthropometric and gene frequencies, may be used to reconstruct human evolution. previous research, reconstructing the history of racial differentiation on the basis of gene frequencies, indicated that the major separation between human groups was that between africans and europeans on one side and peoples from australia, east asia and americas on the other. a similar attempt by howells ('73b), based on skull measurements in 17 ancient populations, in agreement with earlier an ...	1979	88901
independent regulation of phosphorylase and lipolysis in adipose tissue.		1979	88902
a new assay of estrogen receptor by thin-layer gel filtration.		1979	88911
detection of dna-aldehydes in mammalian tissues with aqueous solution of rhodamine s.		1979	89085
antigenic specificity of neutralizing antibody to cholera toxin.	selected rabbit antisera to cholera toxin antigens and convalescent cholera patient sera were analyzed using the permeability factor neutralization test and two sensitive in vitro serological assays specific for cholera toxin, cholera toxin a subunit, and cholera toxin b subunit. the results indicated that antisera to cholera toxin contained toxin-neutralizing activity as well as antibodies specific for both the a subunit and b subunit. it was clearly established that antisera to b subunit, devo ...	1979	89089
characterisation of the reaginic response to sulphonamides in mice.	reaginic responses were induced in immunised mice with either 4-sulphanilamidobenzoic acid (4-saba) or sulphamethoxazole (smx) coupled to chicken gamma-globulin (cgg). the former was coupled through the carboxylic group of benzoic acid and the latter through the diazo derivative of the sulphanilamide group. the specificity of the reaginic responses obtained was assessed in each case by inhibition of passive cutaneous anaphylaxis in the rat. immunisation with 4-saba-cgg resulted in antibodies whi ...	1979	89094
methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mrna's.	translation of total mrna in heterologous protein-synthesizing systems is often employed as an indirect means of assessing relative mrna concentrations. however, it is well known that the efficiency of translation of specific mrnas differs. one such example is the poor translational efficiency of conalbumin mrna relative to ovalbumin mrna. in this report we have studied the translation of conalbumin and ovalbumin mrnas in crude mrna preparations and with highly purified mrna preparations. we fin ...	1979	89113
preparative isolation of the cell receptor for immunoglobulin e.		1979	89114
phosphomolybdic and phosphotungstic acid--victoria blue r stains two histochemically distinct collagens: dense dark blue and loose areolar pale green.		1979	89156
acid fast staining of oxidized neuromelanin and lipofuscin in the human brain.	acid fast staining of the bleached residuum of substantia nigra neuromelanin and of oxidized inferior olive lipofuscin was demonstrated in paraffin and frozen sections stained with the acetic acid, carbol fuchsin method of barbeito-lopez and the aldehyde fuchsin method of gomori. acid fast staining occurred when sections were exposed to a prestain oxidation with potassium permanganate in conjunction with a poststain differentiation with dilute hydrochloric acid. the acid fast staining with aceti ...	1979	89189
definition of cellular immune responses to brain antigens in human head trauma.	cellular immune responses to brain antigens in patients with head injury were studied by applying the leukocyte adherence inhibition (lai) assay. the investigation was conducted in three phases. 1) in the initial phase, evaluation of a series of 22 test and 25 control cases obtained at random during a 2- to 6-week time frame following a traumatic event indicated significant non-adherence of leukocytes (nal) in 77% of the test group and 20% of the control group in the presence of brain antigen. 2 ...	1979	89190
antigenic changes associated with liver carcinogenesis.	carcinogen-induced experimental hepatomas are often characterized by new individually distinct antigens capable of inducing tumor immunity in syngeneic hosts. these antigens arise as a consequence of cell-carcinogen interaction and may result from modification or replacement of normal cell-surface components. their role in immunosurveillance is not established, but they offer a target for tumor immunotherapy. reexpressed fetal antigens have also been detected, either as secretory products (alpha ...	1979	89200
[technic of the ring precipitation test].		1979	89259
antiviral compound effective against experimental scrapie.		1979	89602
simulation and prevention of retrovirus--specific reactions by mycoplasmas.	from human mycosis fungoides tumor-derived cell lines, mycoplasma hyorhinis was isolated. this mycoplasma shared the following characteristics with retroviruses: uptake of 3h-uridine, but not of 3h-thymidine in cell culture; banding at 1.16 g/ml sucrose density and partial shift to retrovirus core density position (approximately equal to 1.24 g/ml) after detergent treatment; incorporation of 3h-tmp into high molecular weight material in standard reverse transcriptase assays with the template-pri ...	1979	89623
prostaglandin e1 activation of heart camp-dependent protein kinase: apparent dissociation of protein kinase activation from increases in phosphorylase activity and contractile force.		1979	89626
carcinomas of the liver in rats ingesting kepone.	young male and female albino rats ingested 0, 1, 5, 10 or 25 ppm kepone, an organochlorine pesticide, in the diet for two years. carcinomas of the liver, as well as hyperplastic nodules and moderate and severe diffuse hyperplasia were observed in kepone-treated rats. such hepatic lesions were not seen in control rats. female rats ingesting kepone were more susceptible than male rats to hepatic carcinogenesis. rats ingesting 50 or 80 ppm kepone developed severe diffuse hepatic hyperplasia and did ...	1979	89631
human b cell function in a polyclonally induced plaque forming cell system. cell triggering and immunoregulation.	the use of a sensitive pfc assay against a specific antigenic determinant (srbc) following polyclonal triggering of human lymphocytes has provided a unique insight into the complex mechanisms of triggering of human b cells. the system is under the strict regulation of a delicate balance between helper and suppressor influences reflecting in certain circumstances the activity of distinct subsets of immunoregulatory cells. lymphoid cells in certain diseases characterized by disordered immunoregula ...	1979	89732
definition of lymphocyte antigens in rats: rt-ly-1, rt-ly-2, and a new mhc-linked antigen system.		1979	89738
serologic characteristics of different subpopulations of human non-t lymphocytes.		1979	89742
interactions of retroviruses with chemical carcinogen. i. noncovalent binding of unactivated polycyclic aromatic hydrocarbons.		1979	89755
strain-specific antigens in rhizobium leguminosarum.	fifty strains of rhizobium leguminosarum, isolated from five species of host plant (pisum sativum, p. arvense, vicia sativa, v. faba, and a lathyrus sp.) were examined for the presence of strain-specific somatic antigens by immune-diffusions against 13 antisera. thirty eight strains (76 per cent) were found to belong to the same sero-group and were serologically indistinguishable from each other, but four of these strains also exhibited non-reciprocal cross reactivity with other antisera. in con ...	1979	89766
histological diagnosis of myocardial injury. comparison of hematoxylin-basic fuchsin-picric acid (hbfp)-stained sections obtained during autopsy with isolated viable rat cardiac myocytes exposed to anoxia.	the light microscopic appearances in hematoxylin-basic fuchsin-picric acid (hbfp)-stained histological sections from cardiac and skeletal muscle tissue were put in relation to the reactions of isolated viable rat cardiac myocytes exposed to anoxia in suspension and their morphology in paraffin-embedded sections. special attention was paid to prenecrotic phases of myocytic injury which were followed, in viable rat cardiac myocytes, by light microscopy, and confirmed with biochemical assays indica ...	1979	89781
mammary tumor viruses.		1979	89801
antibodies in histoplasmosis detected by use of yeast and mycelial antigens in immunodiffusion and electroimmunodiffusion.		1979	89825
heterogeneity of constitutive heterochromatin in somatic syrian hamster chromosomes.	syrian hamster constitutive heterochromatin was analyzed for c-band distribution and for bru late-replication pattern. characteristic for this species is relatively large amounts of sex-chromosome and autosomal heterochromatin. the distribution of constitutive heterochromatin was determined. the long term of the x chromosome, the whole y, the short arms of 8 autosomal pairs, the long arm of the smallest metacentric pair, and the centromeric regions of 12 pairs stained intensely dark on c-band pr ...	1979	88308
palliation of massive hemoptysis from unresectable carcinoma of the lung.	unresectable carcinoma of the lung has traditionally been recognized as a contraindication to surgery in massive hemoptysis. a 60-year-old man had massive hemoptysis. at surgery an unresectable neoplastic mass invading the mediastinum and great vessels was encountered. subtotal resection was accomplished using a stapler (autostapler). the margins of the bronchial and vascular staples were of necessity placed directly through the tumor. the patient had an uneventful recovery and has survived six ...	1979	88310
kinetic complexity of nuclear poly(a)-containing rna in normal and regenerating rat liver.	poly(a)-containing rna isolated from liver nuclei of untreated rats and 3 h or 12 h after partial hepatectomy or sham operation was hybridized to the complementary dnas (cdnas). in the homologous reactions two major components could be seen. when compared to normal liver, the complexity of the least abundant class was lower in nuclei from livers 3 h after partial hepatectomy and was higher in those isolated 12 h after operation. the heterologous reactions revealed an increase of some abundant p ...	1979	88367
leishmania mexicana and leishmania tropica: cross immunity in c57bl/6 mice.		1979	88370
renal cortex sialyltransferase activity upon tamm-horsfall glycoprotein, fetuin and rat glomerular basement membrane.		1979	88378
inhibition of murine sarcoma virus-induced foci formation by cytidine analogues and other drugs chemotherapeutically effective in human malignancies.	the present report describes an in vitro culture system using the kirsten murine sarcoma virus transformation focus assay to evaluate the antiviral activities of 12 commonly used chemotherapeutically effective drugs. since these drugs are cytotoxic, the plating efficiencies of the cells treated were monitored simultaneously. using this procedure, adriamycin, daunorubicin, bleomycin camptothecin, mithramycin, hydroxyurea, 5-fluorouracil, thioguanine, 9-beta-d-arabinofuranosyladenine, 1-beta-d-ara ...	1979	88425
[partial monosomy 21 in familial cystic fibrosis and ectodermal dysmorphias].		1979	88707
detection of akr mulv-specific rna in akr mouse cells by in situ hybridization.	conditions for the detection of complex rna sequences by in situ hybridization have been investigated by using a single-stranded 3h-cdna probe complementary to the akr mulv genome and in vitro cultured akr mouse cells which spontaneously produce akr mulv. it is shown that fixation with glutaraldehyde at low concentration allows cellular rna to be sufficiently well retained during the annealing process and that stringent conditions in situ can be maintained by means of formamide. some conditions ...	1979	88721
the antiherpesvirus action of phosphonoacetate.		1979	88744
ampicillin-insensitive haemophilus influenzae type b causing acute epiglottitis.		1979	87819
tuberculosis chemotherapy--how long.		1979	87838
synaptic hyperfunction in sympathetic ganglion, its significance in essential hypertension.		1979	87949
[surgical treatment of congenital obstructive biliary disease (author's transl)].	the results of surgical treatment of bile duct atresia and hypoplasia are disappointing; no improval of long-term survival could be observed. with kasai's hepato-jejuno-enterostomy which is not suited for the management of complete atresia. a new surgical procedure was evaluated in animal experimentation and in some patients: the bile was drained through the lymph system of the liver into the intestinal tract. morphology, surgical procedure and indications as pertinent to this new approach are d ...	1979	87998
cell-mediated lysis of lipid vesicles containing eye muscle protein: implications regarding pathogenesis of graves ophthalmopathy.	we prepared artificial vesicles that are lysed upon cell-mediated immunological attack by human lymphocytes. these vesicles are made from a mixture of dimyristoyl lecithin, dipalmitoyl lecithin, and cholesterol, have eye muscle membrane protein (emp) inserted into the bilayer wall, and contain intravesicular (99m)tc marker. injury to the vesicular membrane was assessed by measurement of (99m)tc release. thyroglobulin (tg) and tg-anti-tg complex (tga) bind to emp-vesicles to an extent equal to or ...	1979	88053
counterimmunoelectrophoresis of blood cultures. temporal relationship of positive gram stain to positive counterimmunoelectrophoresis.	counterimmunoelectrophoresis (cie), gram staining, and quantitative measurements were performed on simulated blood cultures at hourly intervals after inoculation with streptococcus pneumoniae, klebsiella pneumoniae, or haemophilus influenzae. the cie became positive either at the same time as the gram stain or within the ensuing five hours. in no case was cie positive when the gram stain was negative. the numbers of colony-forming units milliliter necessary for a positive cie result varied with ...	1979	86293
counterimmunoelectrophoresis for rapid identification of blood-culture isolates.	a total of 303 blood cultures that were positive by examination of gram-stained smears were tested immediately by counterimmunoelectrophoresis for detection of bacterial antigens. antigen was detected in all 82 blood cultures containing streptococcus pneumoniae and 11 of 22 with klebsiella pneumoniae, two of two with haemophilus influenzae, and one of one with neisseria meningiditis. false-positive cross-reactions in 265 tests occurred only with pneumococcal omniserum in two cases of nongroupabl ...	1979	86294
immunochemical, serologic, and immunologic properties of major antigens isolated from the legionnaires' disease bacterium. observations bearing on the feasibility of a vaccine.	two antigens were isolated from each of three strains of the legionnaires' disease (ld) bacterium. one antigen was serotype-specific; the other cross-reacted with strains of ld bacteria of different serotypes. the serotypic antigens contained all the major branched-chain fatty acids characteristic of ld bacteria and were a lipid-protein-carbohydrate complex. electrophoresis resolved the serotypic antigen of knoxville 1 strain into four protein bands and one glycoprotein band with molecular weigh ...	1979	86314
the isolated human cortex. a golgi analysis of krabbe's disease.	the clinical course of a child with krabbe's leukodystrophy was characterized by clinical seizures, startle myoclonus, and paroxysmal activity recorded by eeg. at autopsy in the fourth year, myelinated subcortical axons were destroyed, virtually completely. despite isolation from major subcortical and interhemispheric connections, the cell and fiber pattern of the cortex appeared remarkably normal in routine histologic preparations. the normal range of pyramidal and stellate interneurons were al ...	1979	86346
difference in antigenic reactivity and ultrastructure between fluid-phase c5b-9 and the c5b-9 membrane attack complex of human complement.		1979	86461
purification and characterization of a polyhook protein from caulobacter crescentus.	a polyhook-producing strain of caulobacter crescentus was isolated, and the polyhook protein was purified. the antigenicity and morphology of the polyhook structure are similar to the wild-type hook except that the mutant strain produces a hook structure at least 10-fold the length of wild-type hooks (1.0 versus 0.1 micrometers). the molecular weight of the polyhook protein, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, is 72,000, and the protein has a pi of approxi ...	1979	86537
automatic cell identification and enrichment in lung cancer. iii. light scatter and two fluorescence parameters.	two fluorescence parameters and size are used in a flow through system to enrich sputum specimens for cancer cells. human cells in sputum which are stained with acridine orange show a characteristic distribution of red and green fluorescence from which cancer cells can be localized. the peak enrichment is obtained by selectively sorting cells with the largest values of red and green fluorescence. cancer cells located in other distribution regions having smaller fluorescence intensities show prog ...	1979	86577
cytofluorometric and cytochemical comparisons of normal and abnormal human cells from the female genital tract.	acridine orange staining of exfoliated cells from epithelial tissues facilitates discrimination between normal and abnormal cells: abnormal cells develop highly elevated nuclear fluorescence. comparisons of acridine orange (ao) staining with propidium iodide (pi) or feulgen staining have shown that: (a) pi staining also provides highly elevated nuclear fluorescence from abnormal cells; (b) the distributions of nuclear fluorescence following ao or pi staining were usually not significantly differ ...	1979	86579
sepsis, septicaemia, and the sea.		1979	86842
isolation and characterization of an endogenous type c virus of rhesus monkeys.	a type c retrovirus was isolated from a continuous cell line established from a spontaneous esophageal carcinoma of a rhesus monkey (macaca mulata) by prolonged cocultivation with canine cells. a dna transcript of the viral rna hybridized to a high level and kinetic analysis indicated the presence of multiple copies of the viral genome in rhesus monkey dna, showing that the virus is endogenous in this species. the rhesus monkey virus closely resembles, in several respects, an endogenous type c v ...	1979	87013
leucocyte migration inhibition test as an index of immunological response to measles virus. iv. blood, spleen, lymph nodes and peritoneal exudate cell reaction.	the migration inhibition test of leucocytes isolated both from the peripheral blood, spleen and lymph nodes as well as peritoneal exudate cells of guinea pigs, immunized with the various doses of measles virus was determined. for in vitro testing of cellular immunity to measles virus, viral antigens could be used in both infective and inactivated form.	1979	87118
similarity of casein- and endotoxin-induced, myeloma- associated and aged sjl/j amyloid in various strains of mice.	amyloidosis was induced in a number of strains of mice by repeated injections of casein and endotoxin. spontaneous amyloid was obtained from balb/c mice bearing a myeloma tumor (igg2a producing mopc 173 tumor) and from aged sjl/j mice. both the induced and spontaneous forms were similar in their size, immunological reactivity, peptide maps and in the susceptibility of histological sections to oxidizing agents with or without trypsin digestion. since case-induced murine amyloid resembles the noni ...	1979	87374
mode of action of a 5-nitrofuran drug (sq 18506) against trypanosoma cruzi.		1979	87384
intracellular marking with lucifer yellow ch and horseradish peroxidase of cells electrophysiologically characterized as glia in the cerebral cortex of the cat.	intracellular microelectrodes filled with either lucifer yellow ch, a highly florescent dye, or horseradish peroxidase (hrp) were used to electrophysiologically characterize and mark cells in the cerebral cortex of cat. fifty-eight cells, characterized electrophysiologically as glia, were marked with lucifer yellow ch. all were identified as protoplasmic astrocytes, and included cells in the glia limitans of the molecular layer. an additional 54 cells, similarly characterized as glia, were label ...	1979	87405