Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| cord blood gene expression in infants hospitalized with respiratory syncytial virus bronchiolitis. | only a few infants develop acute bronchiolitis when exposed to respiratory syncytial virus (rsv), and host, environmental, and viral properties are probably all of importance in determining the severity of infection. | 2007 | 17597454 |
| respiratory syncytial virus recombinant f protein (residues 255-278) induces a helper t cell type 1 immune response in mice. | we have developed and evaluated an immunodominant respiratory syncytial virus (rsv) f antigen in a mouse model. the antigenic region corresponding to amino acids 255-278 of the rsv f protein was cloned into a vector containing the ctxa(2)b gene of cholera toxin (ct). the recombinant protein was expressed in escherichia coli and analyzed on sodium dodecyl sulfate-polyacrylamide gels. the purified protein was evaluated by immunoblot and ganglioside gm(1) enzyme-linked immunosorbent assay to confir ... | 2007 | 17603843 |
| kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line. | the binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can be expelled to the extracellular space. here, by use of confocal-laser-scanning microscopy we investigated the kinetics of the modulation of respiratory syncytial virus (rsv) antigen by rsv-specific igg. rsv-infected human epithelial cells (hep-2) were incu ... | 2007 | 17608950 |
| influenza and respiratory syncytial virus in infants and children: relationship with attendance at a paediatric emergency unit and characteristics of the circulating strains. | a study was carried out on 2,696 italian children, aged 0-14 years. the goals were: (1) to define the age-related impact of acute respiratory infections (ari), measured as the risk of attendance at the paediatric emergency room, (2) to better define the importance and proportion of influenza and respiratory syncytial virus (rsv) infections and (3) to acquire deeper knowledge of the influenza strains circulating in infants and children. a standardised emergency unit attendance risk (euar) was cal ... | 2007 | 17610094 |
| rapid and highly sensitive qualitative real-time assay for detection of respiratory syncytial virus a and b using nasba and molecular beacon technology. | the performance of a sensitive and specific qualitative respiratory syncytial virus (rsv) assay based on nasba technology and real-time molecular beacon detection is presented. very low detection limits for both rsv a and rsv b were determined: 95% detection hit-rate of 95 and 47 copies/input in isolation for rsv a and rsv b, respectively. rsv was detected in a wide variety of clinical samples including respiratory swabs, nasopharyngeal aspirates (npa), bronchoalveolar lavages (bal), endotrachea ... | 2007 | 17614146 |
| transmission of rice stripe virus acquired from frozen infected leaves by the small brown planthopper (laodelphax striatellus fallen). | rice stripe disease, caused by rice stripe virus (rsv), is one of the most serious rice diseases in temperate and subtropical regions of the world. since rsv is not transmissible mechanically, an insect transmission test was the original basis for identification of the viral population and cultivar resistance. a simple, rapid and reliable method is described by which virus-free small brown planthoppers acquired rsv from frozen infected rice leaves and transmitted the virus to healthy rice plants ... | 2007 | 17614147 |
| respiratory syncytial virus fusion inhibitors. part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety. | the effect of structural variation of the benzimidazol-2-one ring of rsv fusion inhibitors related to bms-433771 (1) was examined in conjunction with side chain modifications and the introduction of an aminomethyl substituent at the 5-position of the core benzimidazole moiety. replacement of the benzimidazol-2-one moiety with benzoxazole, oxindole, quinoline-2-one, quinazolin-2,4-dione and benzothiazine derivatives provided a series of potent rsv fusion inhibitors 4. however, the intrinsic poten ... | 2007 | 17616396 |
| intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors as in situ tumor vaccine for colorectal cancer. | although cancers can naturally elicit immune responses, immune ignorance is a common observation preventing immune-mediated elimination of tumor cells. we assessed whether intratumoral expression of respiratory syncytial virus fusion (rsv-f) protein, encoded by a replication-defective adenovirus vector (ad.rsv-f), alone or in combination with local coexpression of cytokines can induce tumor-specific immune responses in a syngeneic murine colon cancer model. we confirmed in vitro by dye colocaliz ... | 2007 | 17620425 |
| respiratory syncytial virus rhinosinusitis in intensive care unit patients. | this study reported a case of rhinosinusitis for respiratory syncytial virus in intensive care unit patient. the settings were intensive care unit at hospital das clínicas, university of são paulo medical school, são paulo, brazil. one female hiv-infected patient with respiratory failure and circulatory shock due to splenic and renal abscesses, who developed rhinosinusitis caused by rsv and bacteria. respiratory viruses can play a pathogenic role in airways infection allowing secondary bacterial ... | 2007 | 17625748 |
| differential type i interferon induction by respiratory syncytial virus and influenza a virus in vivo. | type i interferon (ifn) induction is an immediate response to virus infection, and very high levels of these cytokines are produced when the toll-like receptors (tlrs) expressed at high levels by plasmacytoid dendritic cells (pdcs) are triggered by viral nucleic acids. unlike many rna viruses, respiratory syncytial virus (rsv) does not appear to activate pdcs through their tlrs and it is not clear how this difference affects ifn-alpha/beta induction in vivo. in this study, we investigated type i ... | 2007 | 17626092 |
| identification of a cd4 t cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. | pneumonia virus of mice (pvm) causes bronchiolitis and pneumonia in mice. infection is associated with high levels of viral replication in the lungs and results in the functional inactivation of pulmonary virus-specific cd8 t cells. due to its similarity to severe human respiratory syncytial virus (rsv) infection, pvm infection in mice has been proposed as an alternative rsv model. here, we have delineated the minimal requirements for protective t cell immunity in the pvm model. immunization wit ... | 2007 | 17632195 |
| replacement of the respiratory syncytial virus nonstructural proteins ns1 and ns2 by the v protein of parainfluenza virus 5. | paramyxoviruses have been shown to produce proteins that inhibit interferon production and signaling. for human respiratory syncytial virus (rsv), the nonstructural ns1 and ns2 proteins have been shown to have interferon antagonist activity through an unknown mechanism. to understand further the functions of ns1 and ns2, we generated recombinant rsv in which both ns1 and ns2 were replaced by the piv5 v protein, which has well-characterized ifn antagonist activities (deltans1/2-v). expression of ... | 2007 | 17632199 |
| overlapping roles of the rous sarcoma virus gag p10 domain in nuclear export and virion core morphology. | nucleocytoplasmic shuttling of the rous sarcoma virus (rsv) gag polyprotein is an integral step in virus particle assembly. a nuclear export signal (nes) was previously identified within the p10 domain of rsv gag. gag mutants containing deletions of the p10 nes or mutations of critical hydrophobic residues at positions 219, 222, 225, or 229 become trapped within the nucleus and exhibit defects in the efficiency of virus particle release. to investigate other potential roles for gag nuclear traff ... | 2007 | 17634229 |
| withdrawn: immunoglobulin for preventing respiratory syncytial virus infection. | respiratory syncytial virus, the most important cause of lower respiratory tract infections in infants and young children in industrialized countries, is associated with increased morbidity in premature infants with or without bronchopulmonary dysplasia as well as those with congenital heart disease. because of observations that lower rates of disease occur immediately after birth, presumably due to vertical transmission of maternal antibody, and animal studies where protection from pneumonia wa ... | 2007 | 17636681 |
| respiratory syncytial virus: seasonal data for regions of florida and implications for palivizumab. | the aims of this study are to define the length of the respiratory syncytial virus (rsv) season throughout florida and evaluate the american academy of pediatrics (aap) guidelines on the administration of palivizumab in light of the florida data. | 2007 | 17639745 |
| respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc/ccl17. | respiratory syncytial virus (rsv) is a ubiquitous virus that preferentially infects airway epithelial cells, causing asthma exacerbations and severe disease in immunocompromised hosts. acute rsv infection induces inflammation in the lung. thymus- and activation-regulated chemokine (tarc) recruits th2 cells to sites of inflammation. we found that acute rsv infection of balb/c mice increased tarc production in the lung. immunization of balb/c mice with individual rsv proteins can lead to the devel ... | 2007 | 17641031 |
| co-infection of human metapneumovirus with adenovirus or respiratory syncytial virus among children in japan. | human metapneumovirus (hmpv) is one of the etiological agents of acute respiratory tract infections. from june 2005 to may 2006, we collected 185 clinical specimens from children in osaka city, japan, and detected 41 hmpv rna. of the 41 specimens, four (9.8%) also contained other viruses (3 with adenovirus [adv] and 1 with respiratory syncytial virus [rsv]). the clinical symptoms of patients coinfected with adv were indistinct from those of patients mono-infected with hmpv. the symptoms of the o ... | 2007 | 17641470 |
| [effect of leukotriene receptor antagonist on the levels of th1 and th2 cytokines in sera of infants with respiratory syncytial virus pneumonia]. | to investigate the effects of leukotriene receptor antagonist on the levels of th1 and th2 cytokines and the serum cysteinyl leukotrenes (cyslts) in infants and young children with respiratory syncytial virus (rsv) pneumonia. | 2007 | 17653314 |
| monoclonal antibodies in pediatrics: use in prevention and treatment. | an update is provided on monoclonal antibodies (mabs): concept, production, indications for the diagnosis and treatment of neoplastic diseases and autoimmune disorders, prevention of transplant rejection, and treatment of allergic diseases, autoimmune disease and other noninflammatory disorders such as coronary disease. mention is also made of mab use in the prevention of respiratory syncytial virus (rsv) infection. a more extensive account is provided of the use of mab in b cell lymphomas (anti ... | 2007 | 17663923 |
| characteristics and outcome of respiratory syncytial virus infection in patients with leukemia. | little is known about respiratory syncytial virus (rsv) infection in patients with leukemia. the aim of this study was to determine the characteristics, and the outcome of rsv infection with or without therapy with aerosolized ribavirin in leukemia patients. | 2007 | 17666367 |
| preventing respiratory syncytial virus in homebound premature infants. | this article explores the home health nurse's role in preventing respiratory syncytial virus (rsv) among premature infants. thousands of children infected with rsv require hospitalization each year. consistent contact with the infant alerts the nurse to subtle signs and symptoms of rsv infection, which may include nasal congestion, cough, low-grade fever, and malaise. by developing patient and caregiver trust, the home health nurse can implement an rsv prevention plan, leading to a decrease in h ... | 2007 | 17667001 |
| neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. | enlarged adenotonsillar tissue (at) is a major determinant of obstructive sleep apnea (osa) severity in children; however, mechanisms of at proliferation are poorly understood. we hypothesized that early exposure to respiratory syncytial virus (rsv) may modify at proliferation through up-regulation of nerve growth factor (ngf)-neurokinin 1 (nk1) receptor dependent pathways. at harvested from 34 children with osa and 25 children with recurrent tonsillitis (ri) were examined for mrna expression of ... | 2007 | 17667845 |
| serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus. | rous sarcoma virus (rsv) requires large amounts of unspliced rna for replication. splicing and polyadenylation are coupled in the cells they infect, which raises the question of how viral rna is efficiently polyadenylated in the absence of splicing. optimal rsv polyadenylation requires a far-upstream splicing control element, the negative regulator of splicing (nrs), that binds sr proteins and u1/u11 snrnps and functions as a pseudo-5' splice site that interacts with and sequesters 3' splice sit ... | 2007 | 17670832 |
| immunomodulatory constituents of human milk change in response to infant bronchiolitis. | although epidemiological evidence is generally supportive of a causal association between respiratory syncytial virus (rsv) bronchiolitis during infancy and the development of persistent wheeze/asthma, if not allergy, the mechanism by which this occurs and an explanation for why all children do not succumb remains to be elucidated. breast feeding has been found to confer a protective effect against respiratory infections such as rsv bronchiolitis and allergy; however, again there is little direc ... | 2007 | 17680907 |
| respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma. | several respiratory viruses have been shown to cause exacerbations of asthma. while the various viral responses likely have common mechanisms of activation, the respiratory syncytial virus (rsv) appears to promote specific responses that on their own can cause severe pulmonary problems. understanding the mechanisms that promote inappropriate immune responses and local damage may lead to better therapy. the activation and recruitment of t cells that amplify and skew the immune response toward mor ... | 2007 | 17684333 |
| suppression of innate immune cytokines and interferon regulatory factor-1 by endogenous interferon-alpha in response to respiratory syncytial virus in neonate mononuclear cells. | respiratory syncytial virus (rsv) infections are extremely common in early childhood but are most severe in infants in the first few months of life. unresponsive adaptive immunity and hyporesponsive innate immunity were previously found to be the typical responses of neonate mononuclear cells (mcs) to live rsv. investigating the mechanism of innate immune hyporesponsiveness in neonate mcs to live rsv revealed that in contrast to the previously reported low expression of interferon (ifn)-gamma, i ... | 2007 | 17691025 |
| [severe bronchiolitis. epidemiology and clinical course of 284 patients]. | bronchiolitis is the leading cause of hospital admission and a frequent cause of pediatric intensive care unit (picu) admission among infants during the winter months. the objective of this study was to analyze the characteristics and clinical course of patients admitted to the picu for bronchiolitis. | 2007 | 17692256 |
| oral respiratory syncytial virus (rsv) dna vaccine expressing rsv f protein delivered by attenuated salmonella typhimurium. | human respiratory syncytial virus (rsv) is a major viral pathogen of the lower respiratory tract of infants and young children worldwide. no effective prevention measure is available. attenuated salmonella strains expressing heterologous antigens can be delivered by the oral route, triggering efficient antigen-specific humoral, cellular, and mucosal immunity. in this study, we orally administered attenuated salmonella strain sl7207, carrying the plasmid pcdna3.1/f expressing the rsv f gene, to b ... | 2007 | 17696764 |
| local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice. | the effect of ageing on the local defence system against respiratory syncytial virus (rsv) infection was investigated using an aged mouse model of the senescence-accelerated mouse (sam) strain p1. following intranasal infection with rsv, sam-p1 mice showed a marked loss in weight, with elevated virus growth in the lungs and prolonged virus shedding. the increased susceptibility to rsv infection was associated mainly with diminished cellular immunity by local virus-specific cytotoxic t lymphocyte ... | 2007 | 17698666 |
| genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. | respiratory syncytial virus (rsv) is a common cause of severe lower respiratory tract infection in infants. only a proportion of children infected with rsv require hospitalization. because known risk factors for severe disease, such as premature birth, cannot fully explain differences in disease severity, genetic factors have been implicated. | 2007 | 17703412 |
| respiratory syncytial virus protects against the subsequent development of japanese cedar pollen-induced allergic responses. | respiratory syncytial virus (rsv) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans still remain inconclusive. the association between rsv infection and allergic diseases may be dependent on atopic background and previous history of rsv infection. in this study, the influence of the timing of rsv infection on the development of japanese cedar pollen (jcp)-induced allergic responses was examined. balb/c mice were int ... | 2007 | 17705182 |
| the use of health economics to guide drug development decisions: determining optimal values for an rsv-vaccine in a model-based scenario-analytic approach. | health-economic modelling is useful for assessing the clinical requirements and impact of new vaccines. in this study, we estimate the impact of potential vaccination for respiratory syncytial virus (rsv) of infants in the netherlands. a decision analysis model was employed using seasonal data from a cohort of children (1996-1997 through 1999-2000) to assess hospitalisation, costs and impact of vaccination. yearly, an estimated 3670 infants are hospitalised with rsv-infection in the netherlands, ... | 2007 | 17707959 |
| respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. | respiratory syncytial virus (rsv) is a clinically important pathogen. it preferentially infects airway epithelial cells causing bronchiolitis in infants, exacerbations in patients with obstructive lung disease, and life-threatening pneumonia in the immunosuppressed. the p53 protein is a tumor suppressor protein that promotes apoptosis and is tightly regulated for optimal cell growth and survival. a critical negative regulator of p53 is murine double minute 2 (mdm2), an e3 ubiquitin ligase that t ... | 2007 | 17709487 |
| association of tlr4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. | respiratory syncytial virus (rsv) is a leading cause of infant mortality worldwide. although anti-rsv ab prophylaxis has greatly reduced infant mortality in the united states, there is currently no vaccine or effective antiviral therapy. rsv fusion (f) protein activates cells through tlr4. two single nucleotide polymorphisms (snps) encoding asp299gly and thr399ile substitutions in the tlr4 ectodomain were previously associated with tlr4 hyporesponsiveness and increased susceptibility to bacteria ... | 2007 | 17709532 |
| epidemiology of respiratory syncytial virus infection in northern taiwan, 2001-2005 -- seasonality, clinical characteristics, and disease burden. | respiratory syncytial virus (rsv) is an important pathogen in children less than 2 years old. however, there is limited epidemiological data about rsv infection in taiwan. this study aimed to investigate the clinical, epidemiological, virological, and economical aspects of rsv infections in taiwan. | 2007 | 17712463 |
| influenza- and respiratory syncytial virus-associated mortality and hospitalisations. | the aim of the current study was to estimate influenza- and respiratory syncytial virus (rsv)-associated mortality and hospitalisations, especially the influenza-associated burden among low-risk individuals < or =65 yrs old, not yet recommended for influenza vaccination in many european countries. retrospectively during 1997-2003, dutch national all-cause mortality and hospital discharge figures and virus surveillance data were used to estimate annual average influenza- and rsv-associated excess ... | 2007 | 17715167 |
| detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. | traditionally, the identification and quantification of eosinophils in inflammatory tissues and exudates has been primarily based upon morphologic criteria and manual counting. in this study, we describe a new flow cytometry-based assay to enumerate eosinophils present in murine bronchoalveolar lavage fluid (bal) and lung parenchyma obtained from the normal/non-inflamed respiratory tract, following experimentally-induced allergic pulmonary inflammation, and during experimental infection with res ... | 2007 | 17716680 |
| the 24-angstrom structure of respiratory syncytial virus nucleocapsid protein-rna decameric rings. | respiratory syncytial virus (rsv), a nonsegmented, negative-sense rna-containing virus, is a common cause of lower respiratory tract disease. expression of rsv nucleocapsid protein (n) in insect cells using the baculovirus expression system leads to the formation of n-rna complexes that are morphologically indistinguishable from viral nucleocapsids. when imaged in an electron microscope, three distinct types of structures were observed: tightly wound short-pitch helices, highly extended helices, ... | 2007 | 17567697 |
| [acute bronchiolitis, an updated review]. | acute bronchiolitis (ab) is a frequent cause of hospitalization among children and its main etiological agent is respiratory syncytial virus (rsv). it occurs epidemically during autumn and winter. some populations of children such as premature newborns, infants with congenital heart disease and those with chronic lung disease, immunocompromised, undernourished, among others, present increased morbidity and mortality risk. the virus multiplies in epithelial ciliated cells while inflammation and c ... | 2007 | 17568926 |
| evaluation of compliance with palivizumab recommendations in a multicenter study of young children presenting to the emergency department with bronchiolitis. | monthly palivizumab injections from november to march decrease risk of respiratory syncytial virus (rsv)-related hospitalization during rsv season in high-risk infants born less than 35 weeks of gestation. our objective was to investigate compliance with the american academy of pediatrics (aap) recommendations for palivizumab prophylaxis among children who present to the emergency department (ed) with bronchiolitis. | 2007 | 17572518 |
| respiratory syncytial virus fusion inhibitors. part 5: optimization of benzimidazole substitution patterns towards derivatives with improved activity. | extensive sar studies and optimization of adme properties of benzimidazol-2-one derivatives led to the identification of bms-433771 (3) as an orally active rsv fusion inhibitor. in order to extend the structure-activity relationships for this compound series, substitution of the benzimidazole ring was examined with a view to establishing additional productive interactions between the inhibitor and functionality present in the proposed binding pocket. amongst the compounds synthesized, the 5-amin ... | 2007 | 17576060 |
| rsv604, a novel inhibitor of respiratory syncytial virus replication. | respiratory syncytial virus (rsv) is the most common cause of lower respiratory tract infections worldwide, yet no effective vaccine or antiviral treatment is available. here we report the discovery and initial development of rsv604, a novel benzodiazepine with submicromolar anti-rsv activity. it proved to be equipotent against all clinical isolates tested of both the a and b subtypes of the virus. the compound has a low rate of in vitro resistance development. sequencing revealed that the resis ... | 2007 | 17576833 |
| tlr4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. | severe bronchiolitis following respiratory syncytial virus (rsv) infection occurs in only a small subset of infected infants and the basis for variations in disease severity is not understood. innate immune responses to rsv are mediated by tlr-4, and the (299)gly and (399)ile alleles of the tlr4 gene have been linked epidemiologically with increased severity of rsv disease in children. we hypothesized that cellular immune responses to rsv mediated by these variant forms of the receptor are defec ... | 2007 | 17579031 |
| can myoglobin expression in pancreatic beta cells improve insulin secretion under hypoxia? an exploratory study with transgenic porcine islets. | the feasibility of myoglobin (mb)-facilitated oxygen transport in improving porcine islet survival under hypoxia was investigated. discrete groups of islets were transfected with replication-defective adenoviral vector ad5 respiratory syncitial virus (rsv) to induce expression of mb or green fluorescent protein (gfp). native islets served as the controls. in vitro studies at 37 degrees c assessed islet insulin secretion efficacy: (i) to a glucose challenge from 30 to 300 mg/dl at fixed po2; and ... | 2007 | 17584476 |
| genomic analysis of rice stripe virus zhejiang isolate shows the presence of an otu-like domain in the rna1 protein and a novel sequence motif conserved within the intergenic regions of ambisense segments of tenuiviruses. | the complete genome sequence of the four rnas of rice stripe virus zhejiang isolate was determined. in addition to polymerase modules, the pc1 protein encoded on rna1 harbours an ovarian tumour (otu) - like cysteine protease signature near its n-terminus, suggesting that the protein might yield the viral polymerase and one or more additional proteins by autoproteolytic cleavage and/or have deubiquitination activity. a novel inverted repeat sequence motif was found to be universal within the inte ... | 2007 | 17585367 |
| [respiratory syncytial immunoprophylaxis with palivizumab]. | respiratory syncytial virus (rsv) is a serious pathogen causing significant morbidity, especially in premature infants and infants with chronic lung disease or significant congenital heart disease. there is no specific treatment for rsv infection and the therapy is essentially supportive. therefore, prophylaxis is the best strategy against rsv disease. passive immunization with monoclonal antibodies (palivizumab) provides protection against severe rsv infection and significantly reduces hospital ... | 2007 | 17725198 |
| palivizumab and the prevention of respiratory syncytial virus illness in pediatric patients with congenital heart disease. | respiratory syncytial virus (rsv) is a significant pathogen for infants and children with congenital heart disease. non-sustained immunity and failure to develop an effective vaccine has steered rsv management toward a passive immunotherapy strategy in at-risk children. palivizumab is a humanized murine monoclonal antibody targeting the rsv envelope f glycoprotein. in a phase iii clinical trial palivizumab significantly reduced rsv hospitalization in children with significant congenital heart di ... | 2007 | 17727335 |
| [the relationship between rsv bronchiolitis and the development of asthma]. | respiratory syncytial virus (rsv) is the most common cause of bronchiolitis during infancy and is associated with subsequent wheezing and asthma, but the nature of this association is not fully understood. in that sense, rsv bronchiolitis may serve as a marker, reflecting predisposition of the individual for virus-induced wheezing early in life and/ or asthma later in life. this review discusses existing data on rsv infection and respiratory complications later in life, as well as the link betwe ... | 2007 | 17760405 |
| nontypeable haemophilus influenzae and streptococcus pneumoniae bind respiratory syncytial virus glycoprotein. | respiratory syncytial virus (rsv) infection is associated with secondary bacterial infections caused by nontypeable haemophilus influenzae (nthi) and streptococcus pneumoniae. the pathogenesis of these complications is not completely understood; however, viral infection of respiratory epithelial cells promotes colonization by these bacteria. in the present study, rsv virions associated with nthi and pneumococci in an inoculum-dependent manner in a fluid-phase binding assay. adherence of nthi and ... | 2007 | 17761473 |
| pneumonia case-finding in the respire guatemala indoor air pollution trial: standardizing methods for resource-poor settings. | trials of environmental risk factors and acute lower respiratory infections (alri) face a double challenge: implementing sufficiently sensitive and specific outcome assessments, and blinding. we evaluate methods used in the first randomized exposure study of pollution indoors and respiratory effects (respire): a controlled trial testing the impact of reduced indoor air pollution on alri, conducted among children <or= 18 months in rural guatemala. | 2007 | 17768502 |
| [human bocavirus infections in spanish 0-14 year-old: clinical and epidemiological characteristics of an emerging respiratory virus]. | in 2005 a new respiratory virus, called human bocavirus (hbov), was cloned from respiratory samples from swedish infants and children with lower respiratory tract infections. | 2007 | 17785157 |
| inhibition of respiratory syncytial virus of subgroups a and b using deoxyribozyme dz1133 in mice. | respiratory syncytial virus (rsv) commonly infects the upper and lower respiratory tracts. currently, there is no effective treatment available. deoxyribozymes are a potential therapeutic for rsv and their activity is based on the ability to bind and cleave complementary rna sequences to inhibit protein expression. dz1133 is a deoxyribozyme that targets the conserved genomic rna sequence of the rsv nucleocapsid protein and has been shown to significantly inhibit various strains of rsv including ... | 2007 | 17804108 |
| ultrastructural analysis of the interaction between f-actin and respiratory syncytial virus during virus assembly. | during respiratory syncytial virus (rsv) infection there is a close physical interaction between the filamentous actin (f-actin) and the virus, involving both inclusion bodies and the virus filaments. this interaction appears to occur relatively early in the replication cycle, and can be detected from 8 h post-infection. furthermore, during virus assembly we obtained evidence for the participation of an f-actin-associated signalling pathway involving phosphatidyl-3-kinase (pi3k). treatment with ... | 2007 | 17825340 |
| immunogenicity and efficacy of codon optimized dna vaccines encoding the f-protein of respiratory syncytial virus. | respiratory syncytial virus f-protein (rsv-f) is poorly expressed from dna expression plasmids containing the wild type rsv-f open reading frame. by codon optimization, premature polyadenylation signals were deleted and a striking enhancement of rsv-f expression levels was achieved. therefore, the immunogenicity and efficacy of wild type dna vaccines were compared to codon optimized expression plasmids encoding full-length rsv-f or its ectodomain. mice were immunized twice with the different dna ... | 2007 | 17825960 |
| the association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature. | the relation between early respiratory syncytial virus (rsv) infection and later emergence of episodes of wheezing/asthma remains a subject of debate. we carried out a systematic review of studies of the association between rsv infection in the first 36 months of life and the subsequent development of asthma/bronchial hyperreactivity. | 2007 | 17848887 |
| long-lasting balanced immunity and protective efficacy against respiratory syncytial virus in mice induced by a recombinant protein g1f/m2. | respiratory syncytial virus (rsv) is the primary cause of serious lower respiratory tract illness in young children. we have engineered a recombinant candidate vaccine g1f/m2, consisting of a cytotoxic t lymphocyte (ctl) epitope of rsv-m2 protein and a domain of rsv-g protein. in this study, the long-term immunogenicity and protective effect were evaluated. in g1f/m2-immunized mice, special antibodies lasted for more than 19 weeks, and the igg1/igg2a ratio remained a balanced level till the end ... | 2007 | 17850930 |
| alphavirus replicon particles encoding the fusion or attachment glycoproteins of respiratory syncytial virus elicit protective immune responses in balb/c mice and functional serum antibodies in rhesus macaques. | respiratory syncytial virus (rsv) is a major cause of acute respiratory tract disease in humans. towards development of a prophylactic vaccine, we genetically engineered venezuelan equine encephalitis virus (veev) replicons encoding the fusion (fa) or attachment (ga or gb) proteins of the a or b subgroups of rsv. intramuscular immunization with a formulation composed of equal amounts of each replicon particle (3vrsv replicon vaccine) generated serum neutralizing antibodies against a and b strain ... | 2007 | 17850933 |
| virally delivered cytokines alter the immune response to future lung infections. | respiratory syncytial virus (rsv) is an important cause of infant morbidity and mortality worldwide and is increasingly recognized to have a role in the development and exacerbation of chronic lung diseases. there is no effective vaccine, and we reasoned that it might be possible to skew the immune system towards beneficial nonpathogenic responses by selectively priming protective t-cell subsets. we therefore tested recombinant rsv (rrsv) candidates expressing prototypic murine th1 (gamma interf ... | 2007 | 17855518 |
| multiplexed reverse transcriptase pcr assay for identification of viral respiratory pathogens at the point of care. | we have developed a nucleic acid-based assay that is rapid, sensitive, and specific and can be used for the simultaneous detection of five common human respiratory pathogens, including influenza virus a, influenza virus b, parainfluenza virus types 1 and 3, respiratory syncytial virus (rsv), and adenovirus groups b, c, and e. typically, diagnosis on an unextracted clinical sample can be provided in less than 3 h, including sample collection, preparation, and processing, as well as data analysis. ... | 2007 | 17855573 |
| the absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines. | early in the development of respiratory syncytial virus (rsv) vaccines severe disease occurred in children after receipt of formalin-inactivated rsv vaccine. continuing efforts to develop an appropriately attenuated and immunogenic live rsv vaccine have given opportunities to assure that live vaccines are safe through surveillance of children after vaccination. in the present study, the rate of rsv-associated upper respiratory tract illness in 388 children was lower in rsv vaccinated children th ... | 2007 | 17868959 |
| preliminary evaluation of a multiplex reverse transcription-pcr assay combined with a new dna chip hybridization assay for detecting respiratory syncytial virus. | dna chips represent a major advance in microbiology laboratories, enabling the detection of a wide range of possible pathogens using a single test. this study compared a multiplex reverse transcription-pcr combined with dna chip hybridization (prodect bcs rv chip; bcs biotech) with the indirect immunofluorescence test commonly used to detect respiratory viruses. a total of 39 respiratory viruses (38 respiratory syncytial viruses [rsvs] and 1 influenza a virus) were detected in samples from 96 pa ... | 2007 | 17881543 |
| identification of nyasol and structurally related compounds as the active principles from anemarrhena asphodeloides against respiratory syncytial virus (rsv). | three known phenolic compounds, (-)-(r)-nyasol (= 4,4'-(1z,3r)-penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin a (3)--isolated from the rhizomes of anemarrhena asphodeloides--were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (rsv) inhibition. the ic50 values of 1-3 against the rsv-a2 strain, propagated in hep-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin ... | 2007 | 17886842 |
| maternal alcohol ingestion reduces surfactant protein a expression by preterm fetal lung epithelia. | in addition to neurodevelopmental effects, alcohol consumption at high levels during pregnancy is associated with immunomodulation and premature birth. premature birth, in turn, is associated with increased susceptibility to various infectious agents such as respiratory syncytial virus (rsv). the initial line of pulmonary innate defense includes the mucociliary apparatus, which expels microorganisms trapped within the airway secretions. surfactant proteins a and d (sp-a and sp-d, respectively) a ... | 2007 | 17889311 |
| virucidal activities of medium- and long-chain fatty alcohols and lipids against respiratory syncytial virus and parainfluenza virus type 2: comparison at different ph levels. | recent studies have shown that some lipids and fatty alcohols have microbicidal activities against a broad variety of pathogens. in this study, virucidal activities of fatty acids, monoglycerides and fatty alcohols were tested against respiratory syncytial virus (rsv) and human parainfluenza virus type 2 (hpiv2) at different concentrations, times and ph levels. the most active compounds were mixed with milk products and fruit juices and the mixtures tested for virucidal effects. the aim was to d ... | 2007 | 17891329 |
| differential response of human naive and memory/effector t cells to dendritic cells infected by respiratory syncytial virus. | in vitro studies have contributed substantially to the understanding of immunopathology of respiratory syncytial virus (rsv)-mediated disease. in the present study we compared the effect of rsv-infected dendritic cells on the time-course of the primary and memory/effector t cell response in vitro. cultures with uninfected dendritic cells known to elicit t helper 2 (th2) responses and with polyinosinic-polycytidylic acid (poly-ic)-stimulated dendritic cells known to elicit th1 responses served as ... | 2007 | 17892510 |
| do inhaled corticosteroids improve oxygen saturation in infants with respiratory syncytial virus (rsv) bronchiolitis? | 2007 | 17896613 | |
| systemic aav-9 transduction in mice is influenced by animal age but not by the route of administration. | adeno-associated virus (aav) serotype-9 (aav-9) has attracted great attention as an optimal vehicle for body-wide gene delivery. here we examined the effect of animal age (newborn vs adult) and the route of administration (intravenous vs intra-arterial) on systemic aav-9 transduction. we delivered an alkaline phosphatase (ap) reporter gene aav vector (av.rsv.ap) to either newborn (via either the facial vein or the left ventricular cavity) or adult (via tail vein) c57bl/10 mice. at 12 weeks' post ... | 2007 | 17898796 |
| role of rhinovirus in hospitalized infants with respiratory tract infections in spain. | rhinovirus is a recognized cause of common cold, proven to cause asthma exacerbations in children. in spain, no description exists, as yet, as to the degree of burden rhinovirus infections represent among hospitalized infants. our aim was to describe rhinovirus infections in hospitalized children, under 2 years of age, and to compare these with patients infected with respiratory syncytial virus (rsv). | 2007 | 17901795 |
| modelling the unidentified mortality burden from thirteen infectious pathogenic microorganisms in infants. | official statistics routinely underestimate mortality from specific microorganisms and deaths are assigned to non-specific syndromes. here we estimate mortality attributed to specific pathogens by modelling non-specific infant deaths from laboratory reports and codes on death certificates for these pathogens, 1993-2000 in england and wales using a generalized linear model. in total, 22.4-59.8% of non-specific deaths in infants (25-66 deaths a year) are attributable to specific pathogens. yearly ... | 2007 | 16740187 |
| timing of monoclonal antibody for seasonal rsv prophylaxis in the united kingdom. | respiratory syncytial virus (rsv) infection produces more severe disease and increased hospitalization rates in high-risk babies. the monoclonal antibody palivizumab offers protection against complications, and the first of five monthly doses should be administered before the onset of community rsv activity. however, the required real-time prediction of this onset is problematic. we attempted to identify seasonal rsv patterns by retrospectively examining 10 years of laboratory reports for rsv an ... | 2007 | 16753078 |
| an aetiopathological study of chronic bronchopneumonia in lambs in ireland. | chronic bronchopneumonia in lambs, also known as 'atypical' or 'chronic, non-progressive' pneumonia is a common, frequently sub-clinical disease affecting animals under 12-months-old in intensive production systems. infection with both mycoplasma ovipneumoniae and mannheimia haemolytica have been implicated in the aetiology of this condition and a variety of pulmonary lesions can result. in this study, detailed laboratory examination of 30 abattoir-derived lungs with the characteristic gross fea ... | 2007 | 16632391 |
| impact of respiratory syncytial virus on hospital admissions in children younger than 3 years of age. | respiratory syncytial virus (rsv) is the main pathogen associated to acute respiratory infections (ari) in children worldwide. | 2007 | 16580073 |
| respiratory syncytial virus infection in fischer 344 rats is attenuated by short interfering rna against the rsv-ns1 gene. | respiratory syncytial virus (rsv) causes severe bronchiolitis and is a risk factor for asthma. since there is no commercially available vaccine against rsv, a short interfering rna against the rsv-ns1gene (sins1) was developed and its potential for decreasing rsv infection and infection-associated inflammation in rats was tested. | 2007 | 17270047 |
| type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus. | previous studies compared uptake by dendritic cells (dc) of 20, 40, 100, 200, 500, 1000, and 2000 nm beads in vivo. when beads were used as antigen carriers, bead size influenced antibody responses and induction of ifn-gamma-producing cd4 and cd8 t cells. beads of 40-50 nm were taken up preferentially by dc and induced particularly strong immunity. herein, we examine immunity induced by minute differences in nanobead size, specifically within a narrow viral-sized range (20, 40, 49, 67, 93, 101, ... | 2007 | 17274665 |
| relative dominance of epitope-specific cd8+ t cell responses in an f1 hybrid mouse model of respiratory syncytial virus infection. | cd8+ cytotoxic t lymphocytes are key effectors of adaptive immunity for the control of virus infections. epitope-specific responses are hierarchical and the rules for dominance are not well defined. here we show that the h2-kd-restricted rsv m2(82-90) (kdm2(82-90)) epitope dominates the h2-db-restricted rsv m187-195 (dbm187-195) epitope and influences epitope-specific effector function in the acute and memory phases of the immune response to primary rsv infection in h-2b/d hybrid mice. the hybri ... | 2007 | 17275872 |
| detection of human metapneumovirus in hospitalized children with acute respiratory tract infection using real-time rt-pcr in a hospital in northern taiwan. | human metapneumovirus (hmpv) is a newly discovered respiratory pathogen. this prospective hospital-based study investigated the clinical role and features of hmpv in taiwan. | 2007 | 17282966 |
| relationship between five common viruses and febrile seizure in children. | to examine the role of viruses in febrile seizures (fs) by comparing the relative risk (rr) of developing fs with common viral infections and subsequent risk of recurrence. | 2007 | 17284480 |
| contribution of viruses, chlamydia spp. and mycoplasma pneumoniae to acute respiratory infections in iranian children. | the study reports the frequency and clinical presentation of respiratory syncytial virus (rsv), human metapneumovirus, influenza (inf v), parainfluenza, adenovirus (adv), chlamydia spp. and mycoplasma pneumoniae in children with acute respiratory infections (ari) in rasht, iran. nasopharyngeal aspirates and swabs were collected from 261 children in 2003 and 2004. pathogens were detected using polymerase chain reaction (pcr) and reverse transcription-pcr (rt-pcr), confirmed with sequence analysis ... | 2007 | 17287243 |
| inhibition of airway na+ transport by respiratory syncytial virus. | in previous studies, we have shown that two major respiratory pathogens, influenza virus and parainfluenza virus, produce acute alterations in ion transport upon contacting the apical membrane of the respiratory epithelium. in the present study, we examine the effects on ion transport by the mouse tracheal epithelium of a third major respiratory pathogen, respiratory syncytial virus (rsv). rsv infections are associated with fluid accumulation in the respiratory tract and cause illnesses that ran ... | 2007 | 17287265 |
| morbidity profiles of patients consulting during influenza and respiratory syncytial virus active periods. | we compared the burden of illness due to a spectrum of respiratory diagnostic categories among persons presenting in a sentinel general practice network in england and wales during periods of influenza and of respiratory syncytial virus (rsv) activity. during all periods of viral activity, incidence rates of influenza-like illness, bronchitis and common cold were elevated compared to those in baseline periods. excess rates per 100,000 of acute bronchitis were greater in children aged <1 year (me ... | 2007 | 17291381 |
| effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. | respiratory syncytial virus (rsv) is a common pathogen in the lower respiratory tract of infants and children. recent studies have shown that in adults, especially in the elderly population who have relatively weak immunity, lower respiratory tract infection is not uncommon. rsv was detected in 22% hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (copd), and the detection rate was only next to that of parvovirus and influenza virus respectively. further stud ... | 2007 | 17254480 |
| human metapneumovirus induces more severe disease and stronger innate immune response in balb/c mice as compared with respiratory syncytial virus. | human metapneumovirus (hmpv) and respiratory syncytial virus (rsv) are members of the pneumovirinae subfamily of paramyxoviridae and can cause severe respiratory disease, especially in infants and young children. some differences in the clinical course of these infections have been described, but there are few comparative data on pathogenesis in humans and animal models. in this study, hmpv and rsv were compared for replication, pathogenesis and immune induction in balb/c mice infected with equi ... | 2007 | 17257445 |
| bovine respiratory syncytial virus infection. | bovine respiratory syncytial virus (brsv) belongs to the pneumovirus genus within the family paramyxoviridae and is a major cause of respiratory disease in young calves. brsv is enveloped and contains a negative sense, single-stranded rna genome encoding 11 proteins. the virus replicates predominantly in ciliated respiratory epithelial cells but also in type ii pneumocytes. it appears to cause little or no cytopathology in ciliated epithelial cell cultures in vitro, suggesting that much of the p ... | 2007 | 17257568 |
| [effects of alternanthera philoxeroides griseb against respiratory syncytial virus infection in mice]. | to investigate the effect of an oral preparation of alternathera philoxeroides griseb (apg) against respiratory syncytical virus (rsv) in mice. | 2007 | 17259148 |
| transforming growth factor beta enhances respiratory syncytial virus replication and tumor necrosis factor alpha induction in human epithelial cells. | asthma is characterized as a chronic inflammatory disease associated with significant tissue remodeling. patients with asthma are more susceptible to virus-induced exacerbation, which subsequently can lead to increased rates of hospitalization and mortality. while the most common cause of asthma-related deaths is respiratory viral infections, the underlying factors in the lung environment which render asthmatic subjects more susceptible to viral exacerbation are not yet identified. since transfo ... | 2007 | 17202225 |
| respiratory syncytial virus infection and recurrent wheeze/asthma in children under five years: an epidemiological survey. | to determine the rates of respiratory syncytial virus (rsv) infection in children under 5 years of age with recurrent wheeze or asthma and compare their clinical presentation, course and outcome with asthmatic children of the same age who did not have rsv. | 2007 | 17207052 |
| a member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mrna expression is altered by common viral and bacterial co-pathogens of otitis media. | cationic antimicrobial peptides (amps), a component of the innate immune system, play a major role in defense of mucosal surfaces against a wide spectrum of microorganisms such as viral and bacterial co-pathogens of the polymicrobial disease otitis media (om). to further understand the role of amps in om, we cloned a cdna encoding a cathelicidin homolog (ccramp) from upper respiratory tract (urt) mucosae of the chinchilla, the predominant host used to model experimental om. recombinant ccramp ex ... | 2007 | 17113647 |
| human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosis. | human metapneumovirus (hmpv) has been isolated from children with acute respiratory infection worldwide. its epidemiology remains to be defined in children with cystic fibrosis (cf). we describe the epidemiology and clinical impact of hmpv in cf children and compared it to respiratory syncytial virus (rsv). | 2007 | 17123316 |
| a 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of copd. | infection is a major cause of acute exacerbations of copd (aecopds). we aimed to study the infectious etiology related to aecopd. | 2007 | 17218555 |
| consideration of the three-dimensional structure of core shells (capsids) in spherical retroviruses. | the problem of three-dimensional organization of retroviral cores has been a matter of interest for the past 30 years. the general opinion in favor of icosahedral symmetry based on electron microscopy observations was questioned when cryo-electron microscopy failed to provide convincing evidence in its favor. more recent studies by cryo-electron microscopy, x-ray crystallography and in vitro assembly of the ca domain of human immuno deficiency virus (hiv), murine leukemia virus (mulv) and rous s ... | 2007 | 17223564 |
| [valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. | a six month-old female infant developed dyspnea when she was treated with valproate sodium (vpa) and zonisamide (zns) for epileptic spasms. two weeks after its onset, her dyspnea was exacerbated by respiratory syncytial virus (rsv) infection. we diagnosed interstitial pneumonitis (ip) based on her chest ct and high serum concentrations of kl-6 and surfactant protein d. her dyspnea improved with the treatment which included steroids, neutrophil elastase inhibitor and discontinuation of vpa and zn ... | 2007 | 17228818 |
| prospective comparison of r-mix shell vial system with direct antigen tests and conventional cell culture for respiratory virus detection. | conventional cell culture (cc) has limited clinical utility as a result of the extended incubation period often required for virus isolation. alternative methodologies have been introduced in an effort to improve turnaround times. one such system, the r-mix shell vial is discussed herein. the study objectives were: (a) to establish r-mix testing parameters as compared to direct antigen testing (dat) and cc, and (b) to assess technical aspects and cost of r-mix in a high volume clinical virology ... | 2007 | 17229589 |
| age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: modulation by anti-inflammatory and antiviral treatment. | respiratory syncytial virus (rsv) is the major cause of severe lower respiratory tract infection in infants and young children. recently, rsv has also been recognized as a serious health risk in elderly individuals, but the pathogenesis of rsv infection in elderly individuals remains unknown. | 2007 | 17230410 |
| herpes simplex virus (hsv) pneumonia in a heart transplant: diagnosis and therapy. | organ transplants are frequently complicated by viral infections. the period of maximum immunosuppression, 1 to 6 months posttransplantation, predisposes one to intracellular pathogens. the most common intracellular viral pathogens in transplant recipients include cytomegalovirus (cmv), herpes simplex virus (hsv), and respiratory syncytial virus (rsv). cytomegalovirus and hsv are common viral pathogens in the early transplant period (0-1 month posttransplant). although respiratory syncytial viru ... | 2007 | 17234480 |
| lack of long-term effects of respiratory syncytial virus infection on airway function in mice. | epidemiological data suggests lower respiratory infections (lri) with respiratory syncytial virus (rsv) are capable of causing long-term abnormalities in airway function. to directly test the effects of rsv lri, we infected adult and weanling balb/c mice with rsv (a2) or vehicle. respiratory system impedance was used to assess baseline airway function and responses to iv methacholine (mch) at 4, 8, 24 and 34 weeks post infection. in vitro airway responses were measured 24 weeks post infection us ... | 2007 | 17236822 |
| preparation of a respiratory syncytial virus human reference serum for use in the quantitation of neutralization antibody. | respiratory syncytial virus (rsv) is the major cause of lower respiratory tract infection in infants, young children and the elderly. yet, the development of a vaccine to protect against rsv infection still remains an unmet need. at present, immune responses to experimental vaccines under investigation are usually evaluated by elisa and/or by neutralization assays against rsv. however, both types of assays are generally performed somewhat differently at different laboratories. an important step ... | 2007 | 17241789 |
| epidemiological and clinical features of hmpv, rsv and rvs infections in young children. | human metapneumovirus (hmpv) has recently been isolated from children with acute respiratory tract infections (rtis). the epidemiological and clinical characteristics of hmpv infection need further investigation. | 2007 | 17241812 |
| palivizumab efficacy in preterm infants with gestational age < or = 30 weeks without bronchopulmonary dysplasia. | the present study was designed to determine the efficacy of administration of palivizumab to preterm infants with gestational age (ga) < or = 30 weeks without bronchopulmonary dysplasia (bpd). all patients born with ga < or = 30 weeks without bpd on day 28 and hospitalized for rsv bronchiolitis in burgundy (12 hospitals) from december 1 to april 30 of the next year were included in this prospective observational study during five successive rsv seasons (1999-2000, 2000-2001, 2001-2002, 2002-2003 ... | 2007 | 17243184 |
| relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: the canadian asthma primary prevention study. | the contribution of respiratory viral infections to the onset of asthma and atopy is controversial. in "high risk" children (n = 455) born into asthmatic/atopic families, we determined the relationship of exposures to common respiratory viruses and concomitant respiratory symptoms, and to subsequent possible asthma and atopy at ages 1 and 2 years. frozen nasal specimens, obtained when children were 2 weeks, 4, 8, and 12 months old, underwent reverse transcription-polymerase chain reaction (rt-pc ... | 2007 | 17245731 |
| cytokine induction by respiratory syncytial virus and adenovirus in bronchial epithelial cells. | in order to broaden our knowledge of the primary immune responses to respiratory syncytial virus (rsv) and adenovirus infections, we compared the concentrations of interleukin (il)-6, il-8, and regulated on activation, normal t cell expressed and secreted (rantes) produced in vitro during rsv and adenovirus infections of bronchial epithelial cells. we infected beas-2b cells-a human bronchial epithelial cell line-with rsv, adenovirus serotype 3, or serotype 7 and measured the concentrations of il ... | 2007 | 17245736 |