Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| difficult-to-detect low-grade infections responsible for poor outcomes in total knee arthroplasty. | in this article, we present the case of a patient with a stiff, painful knee after total knee arthroplasty, and with erythrocyte sedimentation rate, c-reactive protein level, and synovial fluid analysis within normal limits. open biopsy for cultures showed propionibacterium acnes prosthetic joint infection, which was successfully treated with 2-stage revision and intravenous antibiotics. | 2017 | 28666043 |
| olumacostat glasaretil, a promising topical sebum-suppressing agent that affects all major pathogenic factors of acne vulgaris. | hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme a carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. olumacostat glasaretil-mediated sebum suppression may reduce propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation. | 2017 | 28647025 |
| sebum lipids influence macrophage polarization and activation. | as lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. | 2017 | 28646583 |
| propionibacterium acnes pleural empyema following medical thoracoscopy. | propionibacterium acnes (p. acnes) is a gram-positive anaerobic rod and a common skin commensal that colonizes sebaceous glands. it has infrequently been associated with invasive opportunistic infections and can cause implant-associated infections through a biofilm mode of growth. medical thoracoscopy is a common procedure for diagnosis and treatment of exudative pleural effusions; empyema is a recognized complication. we present a rare case of p. acnes pleural empyema 3 weeks following medical ... | 2017 | 28638619 |
| isotretinoin and lymecycline treatments modify the skin microbiota in acne. | oral retinoids and tetracyclines have a major role in acne treatment. here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16s ribosomal rna (16s rrna) gene amplicon sequencing. propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. five taxa, including a streptococcus taxon, differe ... | 2017 | 28636791 |
| antibiotic resistance in acne treatment. | what is the evidence for antibiotic resistance in acne, and how does resistance affect treatment? | 2017 | 28636689 |
| tumour necrosis factor (tnf) inhibitor-induced isolated pleural granulomas: a rare adverse effect. | a 53-year-old man with a history of crohn's disease on infliximab, presented with several weeks of cough and dyspnoea. he had a right-sided pleural effusion, found to be exudative with lymphocytic predominance. he underwent right-sided video-assisted thoracic surgery (vats) with biopsies and pleurodesis. histopathology showed pleural-based non-caseating granulomas with unremarkable lung parenchyma. cultures were only positive for propionibacterium acnes 8 months later, he was found to have a lef ... | 2017 | 28630242 |
| accumulation of porphyrins in propionibacterium acnes by 5-aminolevulinic acid and its esters. | we have investigated the accumulation of porphyrins in propionibacterium acnes (p.acnes) by 5-aminolevulinic acid hydrochloride (ala) and its esters, ala methyl ester hydrochloride (mala), ala octyl ester hydrochloride (oala), and ala benzyl ester hydrochloride (bala). from the fluorescence spectra of porphyrins accumulated in p.acnes, the order of porphyrin accumulation is as follows: ala≫mala≈bala>oala (≈0). moreover, the pdt efficacy is reduced in the order of ala>mala≈bala>oala (≈without add ... | 2017 | 28624551 |
| antimicrobial susceptibility and phylogenetic analysis of propionibacterium acnes isolated from acne patients in japan between 2013 and 2015. | the prevalence of antimicrobial-resistant propionibacterium acnes strains isolated from acne patients has been increasing in japan. here, to estimate the current resistance rate, we tested antimicrobial susceptibility among p. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. rates of resistance to macrolides and clindamycin were 44.3 (31/70) and 38.6% (27/70), respectively. erm(x), which confers high-level clindamycin resistance (minimum inhibitory ... | 2017 | 28623856 |
| temporomandibular prosthetic joint infections associated with propionibacterium acnes: a case series, and a review of the literature. | the orthopedic literature has shown an increasing incidence of prosthetic joint infections (pjis) associated with propionibacterium acnes (p acnes). these infections present serious diagnostic and management challenges to the treating surgeons. in this review, the authors report on cases of p acnes-related temporomandibular joint (tmj) pjis that have been diagnosed and treated at their institution. | 2017 | 28623686 |
| propionibacterium acnes is an unusual cause of acute scrotal abscess in a preterm infant. | acute scrotal abscess is an extremely rare condition in neonates and may mimic testicular torsion. most of these abscesses have reportedly been due to staphylococcus and salmonella spp. infections. we herein report a unilateral acute scrotal abscess in a preterm infant born at 26 weeks in whom propionibacterium acnes was isolated from the collected scrotal fluid culture. to our knowledge, this is the first case report implicating p. acnes as a causative agent of neonatal scrotal abscess. based o ... | 2017 | 28620560 |
| a comparison of culture and pcr methods for identifying propionibacterium acnes in lesions isolated from patients with acne. | one of the factors that affect the occurrence of acne is the presence of propionibacterium acnes. the present study was conducted to compare the culture and polymerase chain reaction (pcr) methods for identifying p. acnes in lesions isolated from patients with acne. | 2017 | 28618752 |
| a polycation antimicrobial peptide mimic without resistance buildup against propionibacterium acnes. | a preliminary study is reported for a polycation antimicrobial peptide (amp) mimic against propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. antibiotics are commonly used against p. acnes but buildup of resistance is well-known. worse, antibiotic regimens build up resistance for more sensitive bacteria such as staphylococcus epidermidis. the polycation amp mimic c12-50, 1, is chosen for the present study as it has been previously shown to have high antimic ... | 2017 | 28605136 |
| in vitro emergence of fluoroquinolone resistance in cutibacterium (formerly propionibacterium) acnes and molecular characterization of mutations in the gyra gene. | in vitro occurrence of levofloxacin (lvx) resistance in c. acnes and characterization of its molecular background were investigated. the mutation frequency was determined by inoculation of 10(8) cfu of c. acnes atcc 11827 (lvx mic = 0.25 mg/l) on lvx-containing agar plates. the progressive emergence of resistance was studied by a second exposure to increasing lvx concentrations. for mutants, the qrdr regions including the gyra and parc genes were sequenced and compared to both c. acnes atcc 1182 ... | 2017 | 28602804 |
| erratum to: high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | 2017 | 28595609 | |
| genetic architecture of acne vulgaris. | acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. | 2017 | 28593717 |
| an unusual pathogen causing native valve endocarditis. | we present the case of a gentleman who was being evaluated for restrictive lung disease and was incidentally found to have mitral valve stenosis on an hrct. during the surgical procedure for valve replacement, he was found to have an abscess around the native mitral valve which was drained. pus from the abscess as well as the valve tissue grew propionibacterium acnes after holding the cultures long. the patient was treated with iv ceftriaxone with good response to therapy. while propionibacteriu ... | 2017 | 28586598 |
| detection of the relatively slow-growing propionibacterium acnes in seven matrices of blood components and advanced therapeutical medicinal products. | relatively slow-growing bacteria like propionibacterium acnes represent a challenge for quality control investigations in sterility release testing of blood components and advanced therapeutic medicinal products (atmps). | 2017 | 28571932 |
| endocrine disorders and hormonal therapy for adolescent acne. | acne vulgaris is a global disease with increasing prevalence in adolescents. it has a profound impact on their quality of life, especially when endocrine disorders are also involved. recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. the present review explores hormonal therapies for the treatment of acne vulgaris. | 2017 | 28562419 |
| effect of propionibacterium acnes (pa) injection on intervertebral disc degeneration in a rat model: does it mimic modic changes? | multiple reports of bacterial isolates in human disc tissue have suggested a role of low-grade infection on intervertebral disc degeneration and modic changes (mc) generation. animal models have been extensively used to study idd; however, until recently, no consideration had been given to eventual infectious processes. to reproduce the phenomena by inoculating an infecting agent would support the infectious hypothesis. therefore, we studied the effect of propionibacterium acnes (pa) inoculation ... | 2017 | 28552835 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| the follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls. | although the pathogenesis of hidradenitis suppurativa (hs) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. insight into the cutaneous microbiome in hs using next-generation sequencing may provide novel data on the microbiological diversity of the skin. | 2017 | 28538949 |
| response to: can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | 2017 | 28526425 | |
| can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | 2017 | 28526424 | |
| high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | a stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (eclipse®). the aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. | 2017 | 28526023 |
| periprosthetic shoulder infection: an overview. | periprosthetic shoulder infection (psi) is rare but potentially devastating. the rate of psi is increased in cases of revision procedures, reverse shoulder implants and co-morbidities. one specific type of psi is the occurrence of low-grade infections caused by non-suppurative bacteria such as propionibacterium acnes or staphylococcus epidemermidis.success of treatment depends on micro-organism identification, appropriate surgical procedures and antibiotic administration efficiency. post-operati ... | 2017 | 28507783 |
| sapho, autophagy, il-1, foxo1, and propionibacterium (cutibacterium) acnes. | overt infection by propionibacterium acnes is lacking in many sapho syndromes, and antibiotics have only a transient and incomplete effect, either in sapho syndrome or acne. as several auto-inflammatory bone disorders sharing overproduction of il-1β can mimic sapho, this syndrome could partly depend on genetically encoded overproduction of il-1β. however, cyclic intracellular infections, mostly by p. acnes, can contribute to the enhanced il-1β release by some skin cells, and probably by bone cel ... | 2017 | 28499891 |
| post-operative spondylodiscitis due to propionibacterium acnes: a case report. | post-operative spondylodiscitis due to propionibacterium acnes is rare, with only a few cases reported in the literature. in this article, we report the case of a 76-year-old patient who suffered from spondylodiscitis t12-l1 discovered after 1 month of pain and fever. antibiotic treatment was administered for 6 weeks without revision surgery. diagnosis remains incomplete, and preventive therapy against this infection is not well known. there is no link between immunosuppression and this infectio ... | 2017 | 28495228 |
| delayed manifestation of shunt nephritis: a case report and review of the literature. | we present an unusual case of shunt nephritis in a 39-year-old male who presented 21 years after placement of a ventriculoperitoneal (vp) shunt. he complained of fevers, headaches, dizziness, and urticarial plaques on arms, trunks, and legs and was found to have anemia, low complement levels, elevated serum creatinine, proteinuria, and new onset microhematuria. blood and urine cultures were negative. renal biopsy showed features of acute tubulointerstitial nephritis attributed to vancomycin use. ... | 2017 | 28487790 |
| benzoyl peroxide and clindamycin topical skin preparation decreases propionibacterium acnes colonization in shoulder arthroscopy. | propionibacterium acnes is a gram-positive anaerobe that can lead to devastating postoperative shoulder infections. the objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of p. acnes colonization during shoulder arthroscopy. | 2017 | 28479255 |
| green synthesis of conjugated linoleic acids from plant oils using a novel synergistic catalytic system. | a novel and efficient method has been developed for converting plant oil into a specific conjugated linoleic acid (cla) using a synergistic biocatalytic system based on immobilized propionibacterium acnes isomerase (pai) and rhizopus oryzae lipase (rol). pai exhibited the greatest catalytic activity when immobilized on d301r anion-exchange resin under optimal conditions (pai dosage of 12 410 u of pai/g of d301r, glutaraldehyde concentration of 0.4%, and reaction conditions of ph 7.0, 25 °c, and ... | 2017 | 28470063 |
| reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. | to examine the magnitude of bacterial load reduction on the surface of the periocular skin 20 minutes after application of a saline hygiene solution containing 0.01% pure hypochlorous acid (hocl). | 2017 | 28458509 |
| tropism and virulence of cutibacterium (formerly propionibacterium) acnes involved in implant-associated infection. | the recognition of the pathogenicity of cutibacterium acnes in implant-associated infection is not always obvious. in this paper, we aimed to distinguish pathogenic and non-pathogenic c. acnes isolates. to reach this goal, we investigated the clonal complex (cc) of a large collection of c. acnes clinical isolates through multi-locus sequence typing (mlst), we established a caenorhabditis elegans model to assess c. acnes virulence and we investigated the presence of virulence factors in our colle ... | 2017 | 28454760 |
| a comparative study of cutibacterium (propionibacterium) acnes clones from acne patients and healthy controls. | cutibacterium (propionibacterium) acnes is assumed to play an important role in the pathogenesis of acne. | 2017 | 28434779 |
| the microbiome of the prostate tumor microenvironment. | the advent of molecular-based methods of identification and characterization of complex microbial populations has led to a new era of microbial discovery. a detailed and comprehensive analysis of the microbial ecosystem of the pathologic and healthy prostate tissues has not been yet reported. | 2017 | 28434677 |
| histological identification of propionibacterium acnes in nonpyogenic degenerated intervertebral discs. | purpose. low-virulence anaerobic bacteria, especially the propionibacterium acnes (p. acnes), have been thought to be a new pathogeny for a series of disc diseases. however, until now, there has been no histological evidence to confirm this link. the purpose of this study was to confirm the presence of p. acnes in nonpyogenic intervertebral discs via histological observation. method. degenerated intervertebral discs were harvested from 76 patients with low back pain and/or sciatica but without a ... | 2017 | 28401158 |
| propionibacterium acnes incubation in the discs can result in time-dependent modic changes: a long term rabbit model. | a case control study of animal model of modic changes (mcs) on rabbits. | 2017 | 28399545 |
| antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria. | propionibacterium acnes and staphylococcus epidermidis are the major skin bacteria that cause the formation of acne. the present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. the antibacterial activity of extract of cinnamon bark and honey were investigated against p. acnes and s. epidermidis using disc diffusion. minimum inhibitory concentrations (mics) and minimum bactericidal concentrations ... | 2017 | 28398231 |
| cationic peptides from peptic hydrolysates of rice endosperm protein exhibit antimicrobial, lps-neutralizing, and angiogenic activities. | in this study, we hydrolyzed rice endosperm protein (rep) with pepsin and generated 20 fractions containing multifunctional cationic peptides with varying isoelectric point (pi) values using ampholyte-free isoelectric focusing (autofocusing). subsequently, we determined antimicrobial activities of each fraction against the pathogens prophyromonas gingivalis, propionibacterium acnes, streptocossus mutans, and candida albicans. fractions 18, 19, and 20 had pi values greater than 12 and exhibited a ... | 2017 | 28987278 |
| what is the role of the bacterium propionibacterium acnes in type 1 modic changes? a review of the literature. | this review presents a summary of the pathology and epidemiology of modic changes and the possible role of propionibacterium acnes. this information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. we also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 modic changes. we conclude with a brief d ... | 2017 | 28985974 |
| comparative effects of schisandrin a, b, and c on propionibacterium acnes-induced, nlrp3 inflammasome activation-mediated il-1β secretion and pyroptosis. | propionibacterium acnes, a common pathogen associated with acne, is also responsible for various surgical infections. schisandrin a, schisandrin b and schisandrin c, the representative lignans of schisandra chinensis (turcz.) baill. extract, inhibit p. acnes-induced inflammation. however, their effects on p. acnes-induced il-1β secretion and pyroptosis mediated by nlrp3 inflammasome activation remain unknown. in this study, we compared the effects of schisandrin a, b, and c (sch a, b, and c) on ... | 2017 | 28972885 |
| impact of sequential culture results on diagnosis and de-escalation of the antibiotic regimen in joint and bone infections. | according to existing guidelines, orthopedic specimens collected in joint and bone infections (jbi) in our institution are cultured on several media sets and incubated for two, seven, and 14 days. the optimal timing for de-escalation of the first-line antibiotic combination according to the culture results needs to be defined. | 2017 | 28972874 |
| an anti-propionibacterium acnes antibody shows heterologous resistance to an actinobacillus pleuropneumoniae infection independent of neutrophils in mice. | porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by actinobacillus pleuropneumoniae (app) and results in tremendous economic losses for the pig breeding industry worldwide. previous studies have demonstrated that propionibacterium acnes (pa) could effectively prevent app infection in mice and pigs. the humoral immune response played a primary role during this process and anti-pa antibody could mediate macrophages to kill the bacteria. however, the role of n ... | 2017 | 28929313 |
| propionibacterium acnes. | infection after implantation of ventriculo-peritoneal (vp) shunts is associated with significant morbidity and mortality. we describe a 9-year-old girl with propionibacterium acnes shunt infection with negative cerebrospinal fluid cultures, diagnosed by broad-range 16s-rrna gene pcr. this case supports the use of this molecular diagnostic technique in shunt infections, where the offending pathogens are difficult to culture using traditional methods. | 2017 | 28902005 |
| the skin bacterium propionibacterium acnes employs two variants of hyaluronate lyase with distinct properties. | hyaluronic acid (ha) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. one of the most prevalent skin microorganisms,propionibacterium acnes, possesses ha-degrading activity, possibly conferred by the enzyme hyaluronate lyase (hyl). in this study, we identified the hyl ofp. acnesand investigated the genotypic and phenotypic characteristics. investigations include the generation of ap. acneshylknockout mutant and hyl activity assays to determine t ... | 2017 | 28895889 |
| inflammatory response of disc cells against propionibacterium acnes depends on the presence of lumbar modic changes. | intervertebral disc with propionibacterium acnes (p. acnes) is suggested to be an etiology of modic type i changes in the adjacent bone marrow. however it is unknown if disc cells can respond to p. acnes and if bone marrow cells respond to bacterial and disc metabolites draining from infected discs. | 2017 | 28884220 |
| acute exacerbation of organizing pneumonia leading to sudden death in a patient with sarcoidosis-lymphoma syndrome. | the subject was an 83-year-old female; she had a history of propionibacterium acnes-related sarcoidosis at the age of 79 years. at diagnosis, she was treated with clarithromycin and achieved remission. four years later, during a routine physical check-up, she presented with pulmonary opacities and swelling of multiple lymph nodes. a definitive diagnosis of lymphoma could not be made by inguinal lymph node biopsy. the patient's general condition was good, and we observed her clinical course. oh t ... | 2017 | 28883276 |
| comparative effects of schisandrin a, b, and c on acne-related inflammation. | inflammatory responses induced by propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. schisandrin a, schisandrin b, and schisandrin c are the representative lignans of schisandra chinensis (turcz.) baill. extract. although anti-inflammatory effects of the lignans have been shown, their effects on acne-related inflammation caused by p. acnes have not been investigated and compared. we pretreated thp-1 human monocytic cells with 5, 10, and 20 μm schisandrin ... | 2017 | 28875271 |
| postoperative deep shoulder infections following rotator cuff repair. | rotator cuff repair (rcr) is one of the most commonly performed surgical procedures in orthopaedic surgery. the reported incidence of deep soft-tissue infections after rcr ranges between 0.3% and 1.9%. deep shoulder infection after rcr appears uncommon, but the actual incidence may be higher as many cases may go unreported. clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. generalized fatigue and s ... | 2017 | 28875126 |
| routine cultures for seemingly aseptic revision shoulder arthroplasty: are they necessary? | propionibacterium acnes has recently gained attention as the leading cause of periprosthetic joint infections (pjis) after shoulder arthroplasty. unlike pjis in the lower extremity, pjis after shoulder arthroplasty usually have an indolent course and are notoriously difficult to diagnose. most of the time, the diagnosis is made after positive intraoperative cultures are taken at the time of revision surgery. adding even more complexity to the diagnosis is the high rate of p acnes-positive cultur ... | 2017 | 28865964 |
| bacterial conjugated linoleic acid production and their applications. | conjugated linoleic acid (cla) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. bacterial biosynthesis of cla is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. many bacterial species have been reported to convert free linoleic acid (la) to cla, h ... | 2017 | 28889933 |
| forensic human identification using skin microbiomes. | the human microbiome contributes significantly to the genetic content of the human body. genetic and environmental factors help shape the microbiome, and as such, the microbiome can be unique to an individual. previous studies have demonstrated the potential to use microbiome profiling for forensic applications, however a method has yet to identify stable features of skin microbiomes that produce high classification accuracies for samples collected over reasonably long time intervals. a novel ap ... | 2017 | 28887423 |
| immune discrepancies during in vitro granuloma formation in response to cutibacterium (formerly propionibacterium) acnes infection. | cutibacterium (formerly propionibacterium) acnes is involved in chronic/low-grade pathologies such as sarcoidosis or prosthetic joint infection (pji). in these diseases, granulomatous structures are frequently observed. in this study, we induced a physiological granulomatous reaction in response to different well-characterized clinical c. acnes isolates in order to investigate the cellular process during granuloma formation. three c. acnes isolates selected according to their origin (pji, sarcoi ... | 2017 | 28859990 |
| propionibacterium acnes infection in the native hip: a case report. | a sixty-five-year-old immunocompetent man with bilateral osteonecrosis of the hip and no prior surgical procedures or trauma was found to have a subacute propionibacterium acnes infection of the femoral head. to our knowledge, this is the first reported case of propionibacterium acnes infection in a native hip in the orthopaedic literature. | 2017 | 29252848 |
| photodynamic action of the red laser on propionibacterium acnes. | photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. | 2017 | 29166495 |
| subclinical propionibacterium acnes infection estimation in the intervertebral disc (spine-id): protocol for a prospective cohort. | low back pain and vertebral endplate abnormalities are common conditions within the population. subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with propionibacterium acnes specifically implicated with in relation to sciatica. the main purpose of this study is t ... | 2017 | 29151051 |
| skin barrier and microbiome in acne. | acne is an immune-mediated chronic inflammatory disease. although several factors are involved in its pathophysiology, this process is not completely understood. androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of propionibacterium acnes which triggers inflammation. knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may he ... | 2017 | 29147769 |
| [periodontal microbiota and microorganisms isolated from heart valves in patients undergoing valve replacement surgery in a clinic in cali, colombia]. | periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. | 2017 | 29373772 |
| cp and cp-pgn protect mice against mrsa infection by inducing m1 macrophages. | corynebacterium pyruviciproducens (c. pyruviciproducens, cp), as a newly discovered immunomodulator, has been confirmed to have a stronger immunoregulation than propionibacterium acnes (p. acnes) of the traditional immune adjuvant, by previous experiments with model antigen ovalbumin and sheep red blood cells. here, it was designed to assess its ability to resist methicillin-resistant staphylococcus aureus (mrsa), since mrsa as a vital gram positive pathogen is characterized by high morbidity an ... | 2017 | 29203871 |
| prevalence of flp pili-encoding plasmids incutibacterium acnesisolates obtained from prostatic tissue. | inflammation is one of the hallmarks of prostate cancer. the origin of inflammation is unknown, but microbial infections are suspected to play a role. in previous studies, the gram-positive, low virulent bacteriumcutibacterium(formerlypropionibacterium)acneswas frequently isolated from prostatic tissue. it is unclear if the presence of the bacterium represents a true infection or a contamination. here we investigatedcutibacterium acnestype ii, also called subspeciesdefendens, which is the most p ... | 2017 | 29201018 |
| g2a attenuatespropionibacterium acnesinduction of inflammatory cytokines in human monocytes. | acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses topropionibacterium acnes(pa). here, we explore a possible mechanism by which a lipid receptor, g2a, regulates immune responses to a commensal bacterium. | 2017 | 29200756 |
| propionibacterium acnes induces autophagy in keratinocytes: involvement of multiple mechanisms. | propionibacterium acnes is a dominant member of the cutaneous microbiota. herein, we evaluate the effects of different p. acnes strains and propionic acid on autophagy in keratinocytes. our results showed that p. acnes strain 889 altered the architecture of the mitochondrial network, elevated the levels of lc3b-ii, beclin-1 and phospho-ampkα, stimulated autophagic flux, facilitated intracellular redistribution of lc3b, increased average number of autophagosomes per cell, and enhanced development ... | 2017 | 29191621 |
| diversity of bacterial communities on the facial skin of different age-group thai males. | skin microbiome varies from person to person due to a combination of various factors, including age, biogeography, sex, cosmetics and genetics. many skin disorders appear to be related to the resident microflora, yet databases of facial skin microbiome of many biogeographies, including thai, are limited. | 2017 | 29177119 |
| developing an in vitro artificial sebum model to study propionibacterium acnes biofilms. | the aim of the present study was to develop a new model system to study propionibacterium acnes biofilms. this model should be representative for the conditions encountered in the pilosebaceous unit. | 2017 | 29175428 |
| corrigendum: proposal to reclassify propionibacterium acnes type i as propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes type ii as propionibacterium acnes subsp. defendens subsp. nov. | 2017 | 29130432 | |
| cutibacterium (formerly propionibacterium) acnes infections associated with implantable devices. | cutibacterium acnes (c. acnes), a gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. the diagnosis of c. acnes implant-associated infections remains challenging. the optimal treatment is a combination of both surgical intervention and antibiotic therapy. areas covered: in this review, we discuss the different types of implant-associated infections caused by c. acnes. we also highlight the clinical manifestation ... | 2017 | 29125405 |
| immunohistochemical detection of propionibacterium acnes in the retinal granulomas in patients with ocular sarcoidosis. | the etiology of sarcoidosis is still obscure; however, mycobacteria and propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. to investigate whether p. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of p. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a p. acnes-specific monoclonal antibody (pab antibody). eleven patients (12 eyes) with sarcoid uveitis were enrolle ... | 2017 | 29123243 |
| identification of low oxygen-tolerating bacteria in prostate secretions of cancer patients and discussion of possible aetiological significance. | the microaerophylic organism propionibacterium acnes has shown consistent association with prostate cancer (pc). studies linking circumcision with reduced pc further support anaerobes involvement as circumcision reduces anaerobe colonisation on the glans penis. a 1988 study linked anaerobes with pc but considered them as opportunists in necrotic tumour. a hypothesis that a "helicobacter-like" process causes pc justified this pilot study. active surveillance patients were enrolled. post-prostate ... | 2017 | 29123122 |
| association between chronic inflammation and latent infection of propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study. | propionibacterium acnes may be considered a new pathogeny for disc degeneration, but its pathological role has remained unclear. this study was designed to determine whether the latent infection of p. acnes was associated with chronic inflammation in degenerated intervertebral discs via quantification of the levels of a series of cytokines and neutrophils. | 2017 | 29086028 |
| [diet in pathogenesis of acne vulgaris]. | acne vulgaris is one of the most common dermatologic condition especially among adolescents. acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of propionibacterium acnes. some of investigations show association between acne and diet. milk increases the level of igf-1 leading to the synthesis of androgen-mediated increases sebum production. chocolate predispose to hyperglycemia and insulinemia which aggravate ... | 2017 | 29084194 |
| antibacterial activity of gold nanorods againststaphylococcus aureusandpropionibacterium acnes: misinterpretations and artifacts. | the antibacterial activity of gold nanorod (gnr) suspensions of different surface functionalities was investigated against standard strains ofstaphylococcus aureusandpropionibacterium acnes, taking into consideration two commonly "overlooked" factors: the colloidal stability of gnr suspensions upon mixing with bacterial growth media and the possible contribution of "impurities/molecules" in gnr suspensions to the observed antibacterial activity. the results demonstrated that cationic polyallylam ... | 2017 | 29070948 |
| in-vitro evaluation of marine derived fungi against cutibacterium acnes. | cutibacterium acnes (or propionibacterium acnes) is the main target for the prevention and medical treatment of acne vulgaris. the aim of this study was to evaluate the in vitro anti-c. acnes and anti-s. epidermidis properties of some marine fungi isolated from different indian marine environments. seventy fungal isolates were obtained from samples collected from the west coasts and andaman island, india. methanol extracts of 35 isolates were screened for their antibacterial properties and 5 out ... | 2017 | 29100929 |
| low-level red led light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne. | acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (psu), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of propionibacterium acnes (p. acnes), and increased inflammatory mediator release. light therapy has attracted medical interests as a safe alternative treatment for acne. both blue and red light therapies at high doses >10 j/cm2have demonstrated marked effects on inflammatory acne lesions. ho ... | 2017 | 29095531 |
| computed tomography fistulography of the sternum. a case report on interprofessional collaboration between radiologist and surgeon. | trans sternal fistula can occur after sternotomy/heart surgery. diagnosing this can be difficult. | 2017 | 29055879 |
| draft genome sequences of three multidrug-resistant cutibacterium (formerly propionibacterium) acnes strains isolated from acne patients, china. | cutibacterium acnes (formerly propionibacterium acnes), an anaerobic gram-positive bacterium, is a skin commensal and is considered to be associated with acne. here we report the draft genome sequences of three multidrug-resistant (mdr) c. acnes strains (ca17, ca39 and ca51) isolated from skin lesions of acne patients in china. | 2017 | 29051020 |
| [persistent extra-axial post-surgical collections and propionibacterium acnes infection. presentation of two cases and literature review]. | it is common to observe the persistence of extra-axial collections after craniotomies. most of these disappear in weeks or months but some remain. the onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as propionibacterium acnes (p. acnes). | 2017 | 29033263 |
| constrictive pericarditis caused by cutibacterium (propionibacterium) acnes: a case report and review of literature. | constrictive and effusive-constrictive pericarditis are rare cardiac disorders. only rarely are the conditions caused by purulent infection, and even more infrequently by anaerobe bacteria. we describe a case of constrictive - and effusive-constrictive pericarditis due tocutibacterium (formerlypropionibacterium) acnesin a 75-year old, immunocompetent and previously healthy patient without any predisposition. the patient was successfully treated with subtotal pericardiectomy and beta-lactam antib ... | 2017 | 29021959 |
| in vitroactivities of pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin structure infections. | pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. the mic90s of studied isolates were as follows:bacteroides fragilis, 16 μg/ml; otherb. fragilisgroup spp., 4 μg/ml;prevotellaandfusobacteriumspp., 32 μg/ml;porphyromonasspp., 64 μg/ml;propionibacterium acnes, 4 μg/ml;eggerthella lentaandpeptostreptococcus anaerobius, 32 μg/ml; other gram-positive rods and cocci, 4 μg/ml;clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. pexiganan cr ... | 2017 | 28993327 |
| clinical and microbiological profile of infectious keratitis in an area of madrid, spain. | to study antibiotic susceptibility in bacterial keratitis (bk), its profile over 10 years and its influence on ophthalmological practice. | 2017 | 28993066 |
| long-term effects of cataract surgery with topical levofloxacin on ocular bacterial flora. | to clarify the long-term effect of topical antibiotics on the ocular bacterial flora after cataract surgery. | 2017 | 28991607 |
| contamination occurs during acl graft harvesting and manipulation, but it can be easily eradicated. | why anterior cruciate ligament (acl) autograft soaking in a 5 mg/ml vancomycin solution decreases the rate of infection has not been well-explained. one hypothesis is that grafts can be contaminated during harvesting and vancomycin eradicates the bacteria. the purpose of the present study is to assess how the vancomycin solution acts against acl graft contamination during graft harvesting and preparation. | 2018 | 28988312 |
| propionibacterium avidum: a virulent pathogen causing hip periprosthetic joint infection. | propionibacteria are important members of the human skin microbiota, but are also opportunistic pathogens associated with periprosthetic joint infection (pji). while the role of propionibacterium acnes in pji has been widely described, insight into the capacity of propionibacterium avidum to cause pji is limited. | 2018 | 29020266 |
| propionibacterium acnes as an emerging pathogen in skull base osteomyelitis: a case series. | skull base osteomyelitis (sbo) is recognized as a potentially life-threatening infection that has been classically attributed to pseudomonas aeruginosa. however, growing data shows that the bacteriology of sbo is changing. traditionally thought of as commensal bacterium, p. acnes has been implicated as a serious pathogen in other specialties. building on a previous case report from our institution, we have identified three patients with sbo who are culture-positive for propionibacterium acnes as ... | 2018 | 28994125 |
| colonization of oropharynx and lower respiratory tract in critical patients: risk of ventilator-associated pneumonia. | to investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (bal), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard dna-dna hybridisation. also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship ... | 2018 | 29031240 |
| targeted intervention of acute postoperative infection after rotator cuff repair results in good functional outcomes. | the primary goal of this retrospective review of a prospective database was to document the functional results after acute postoperative deep infection following rotator cuff repair in a single orthopaedic unit over a period of 5 years. secondary goals were to document the effect of infection on healing of the cuff repair and to describe its incidence, diagnostic challenges, pathogens and management. | 2018 | 29022059 |
| performance of implant sonication culture for the diagnosis of periprosthetic shoulder infection. | diagnosing infection after shoulder arthroplasty can be a challenge because of the high prevalence of low-virulence organisms, such as propionibacterium acnes. the purpose of this study was to evaluate the utility of implant sonication fluid cultures in the diagnosis of periprosthetic joint infection compared with standard culture techniques in patients undergoing revision shoulder arthroplasty. | 2018 | 29037535 |
| detection of clinical cutibacterium acnes isolates in different becton dickinson blood culture vials. | 2018 | 29093107 | |
| medicinal mascarene aloes: an audit of their phytotherapeutic potential. | a phytochemical and biological investigation of the endemic mascarene aloes (aloe spp.), including a. tormentorii (marais) l.e.newton & g.d.rowley, a. purpurea lam, a. macra haw., a. lomatophylloides balf.f and a. vera (synonym a. barbadensis mill.), which are used in the traditional folk medicine of the mascarene islands, was initiated. methanolic extracts of the aloes under study were analysed using high resolution lc-uv-ms/ms and compounds belonging to the class of anthraquinones, anthrones, ... | 2018 | 29066297 |
| targeted sequencing of clade-specific markers from skin microbiomes for forensic human identification. | the human skin microbiome is comprised of diverse communities of bacterial, eukaryotic, and viral taxa and contributes millions of additional genes to the repertoire of human genes, affecting human metabolism and immune response. numerous genetic and environmental factors influence the microbiome composition and as such contribute to individual-specific microbial signatures which may be exploited for forensic applications. previous studies have demonstrated the potential to associate skin microb ... | 2018 | 29065388 |
| the antimicrobial effect of cen1hc-br against propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. | propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. an antimicrobial peptide named cen1hc-br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against p. acnes. to examine the potency of cen1hc-br in acne treatment, we conducted experiments to analyze the antibacterial and anti- ... | 2018 | 29108811 |
| perioperative antibiotic prophylaxis has no effect on time to positivity and proportion of positive samples: a cohort study of 64 cutibacterium acnes bone and joint infections. | if a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. this practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. we aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion ... | 2018 | 29167293 |
| decrease in diversity of propionibacterium acnes phylotypes in patients with severe acne on the back. | propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: ia1, ia2, ib, ic, ii and iii. this study investigated p. acnes subgroups on the face and back in patients with severe acne and in healthy controls. in 71.4% of patients with severe acne, p. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. the healthy group carried phylotypes ia1 (39.1%) and ii (43.4%), whereas the acne group carried ... | 2018 | 29136261 |
| detection of bacteria colonizing titanium spinal implants in children. | bacterial colonization of spinal implants may cause severe complications in patients with early-onset scoliosis. correct diagnosis and detection of microbiologic formation is crucial to prevent delayed infections caused by bacterial colonization. the purposes of this study were to estimate the rate and risk factors of colonization of vertical expandable prosthetic titanium rib (veptr) implants in children and to compare the different methods for detecting microbiologic formation on the spinal im ... | 2018 | 29190173 |
| bacterial colonisation of suture material after routine neurosurgical procedures: relevance for wound infection. | wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity, increased cost and patient discomfort. here we aimed to investigate the relevance of bacterial colonisation on suture material using polymerase chain reaction (pcr) to detect and taxonomically classify bacterial dna in patients with and without wound healing problems after routine neurosurgical procedures. | 2018 | 29189910 |
| microbiology alloplastic total joint infections: a 20-year retrospective study. | prosthetic joint infection (pji) is a rare complication of temporomandibular joint replacement (tjr). this study evaluated tjr pjis at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of tjr. | 2018 | 29178982 |
| on revealing the gene targets of ebola virus micrornas involved in the human skin microbiome. | ebola virus, a negative-sense single-stranded rna virus, causes severe viral hemorrhagic fever and has a high mortality rate. histopathological and immunopathological analyses of ebola virus have revealed that histopathological changes in skin tissue are associated with various degrees of endothelial cell swelling and necrosis. the interactions of microbes within or on a host are a crucial for the skin immune shield. the discovery of micrornas (mirnas) in ebola virus implies that immune escape, ... | 2018 | 29312814 |
| tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature. | the aim of this paper was to systematically review the evidence linking propionibacterium acnes (p. acnes) with the develop tanycytic ependymoma (tce) is a rare variant of ependymoma and management guidelines for patients with this disease are not established. | 2018 | 28884561 |
| phenotype and antimicrobial activity of th17 cells induced by propionibacterium acnes strains associated with healthy and acne skin. | studies of the human skin microbiome suggest that propionibacterium acnes strains may contribute differently to skin health and disease. however, the immune phenotype and functions of t helper type 17 (th17) cells induced by healthy (ph) versus acne (pa) skin-associated p. acnes strains are currently unknown. we stimulated peripheral blood mononuclear cells from healthy donors and observed that pastrains induce higher il-17 levels than phstrains. we next generated phand pastrain-specific th17 cl ... | 2018 | 28864077 |
| effectiveness of meibomian gland massage combined with topical levofloxacin against ocular surface flora in patients before penetrating ocular surgery. | to investigate the bacterial profile in the conjunctiva and meibomian glands in patients before penetrating ocular surgeries, and to compare the anti-bacterial efficacy of 0.5% levofloxacin and its combination with meibomian gland massage. | 2018 | 28890180 |
| glucocorticoids and toll-like receptor 2 cooperatively induce acute-phase serum amyloid a. | serum amyloid a (saa) is a highly conserved acute-phase protein and extrahepatic produced saa1/2 contributes to cutaneous inflammation. prolonged systemic or topical treatment with glucocorticoids can provoke skin diseases such as steroid-induced acne. glucocorticoids increase toll-like receptor 2 (tlr2) expression, however, an inflammatory mediator linked to this side effect remains elusive. we report that tlr2 agonists in combination with dexamethasone substantially increase saa expression and ... | 2018 | 28941781 |